Page last updated: 2024-09-27

Chorea Gravidarum

A rare movement disorder developed during PREGNANCY, characterized by involuntary jerky motion (CHOREA) and inability to maintain stable position of body parts (ATHETOSIS). RHEUMATIC FEVER and collagen vascular disorders are frequently associated with this disease. Chorea may vary from mild to severe and occurs in approximately 1 per 2,000 to 3,000 pregnancies. (From Md Med J 1997 Sep;46(8):436-9)

Synonyms(3)

Synonym
Choreoathetosis, Pregnancy-Associated
Chorea Gravidarum
Chorea, Pregnancy-Induced

Research Excerpts

Overview

ExcerptReference
"Chorea gravidarum is a rare syndrome in pregnancy."( Aygun, E; Dansuk, R; Karageyim, AY; Kars, B; Turan, MC; Unal, O, 2002)

Research

Studies (12)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (33.33)23.3326
1990's0 (0.00)12.5806
2000's4 (33.33)18.1394
2010's4 (33.33)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
caffeine0low10
chlorpromazine0low20
fentanyl0low10
haloperidol0low20
promazine0low10
succinylcholine0low10
reserpine0low10
phenothiazine0low10
methyldopa0low10
cortisone0low10
etomidate0low10
ascorbic acid0low10
warfarin0low10

Protein Targets (503)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase5005
RAR-related orphan receptor gamma8008
GLI family zinc finger 39009
AR protein8008
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 46006
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 18008
estrogen-related nuclear receptor alpha7007
estrogen nuclear receptor alpha100010
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
IDH14004
euchromatic histone-lysine N-methyltransferase 2110011
chromobox protein homolog 18008
nuclear factor erythroid 2-related factor 2 isoform 22002
thyroid hormone receptor beta isoform 27007
nuclear factor erythroid 2-related factor 2 isoform 17007
lethal(3)malignant brain tumor-like protein 1 isoform I2002
geminin7007
lethal factor (plasmid)9009
lamin isoform A-delta104004
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0617
Spike glycoprotein4116
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Chitinase0101
phosphopantetheinyl transferase3003
GLS protein5005
nuclear receptor subfamily 1, group I, member 35005
retinoid X nuclear receptor alpha5005
farnesoid X nuclear receptor5005
pregnane X nuclear receptor8008
thyroid stimulating hormone receptor5005
v-jun sarcoma virus 17 oncogene homolog (avian)5005
atrial natriuretic peptide receptor 1 precursor2002
thyroid hormone receptor beta isoform a3003
DNA polymerase beta4004
nuclear receptor ROR-gamma isoform 14004
DNA polymerase kappa isoform 13003
muscarinic acetylcholine receptor M16006
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Voltage-dependent calcium channel gamma-2 subunit3003
Potassium channel subfamily K member 20213
Bile salt export pump0808
Glycogen phosphorylase, muscle form0101
Renin0101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Cholinesterase0101
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0213
Adenosine receptor A30303
Replicase polyprotein 1ab0213
Glutamate receptor 23003
Amine oxidase [flavin-containing] A0303
Acetylcholinesterase0101
Adenosine receptor A10304
Amine oxidase [flavin-containing] B0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A30101
Adenosine receptor A2a0214
Adenosine receptor A2b0102
Adenosine receptor A2b0203
Adenosine receptor A10114
Adenosine receptor A2a0204
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A2a0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10001
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0123
Endochitinase B10101
Muscarinic acetylcholine receptor0001
Canalicular multispecific organic anion transporter 10505
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Guanine deaminase0101
ATP-dependent phosphofructokinase5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Proteasome subunit beta type-110001
thioredoxin reductase7007
ATAD5 protein, partial4004
Fumarate hydratase3003
USP1 protein, partial4004
NFKB1 protein, partial2002
TDP1 protein8008
Microtubule-associated protein tau4004
Thrombopoietin4004
Smad32002
caspase 7, apoptosis-related cysteine protease3003
estrogen receptor 2 (ER beta)2002
progesterone receptor5005
NADPH oxidase 10202
G2002
cytochrome P450 2D63003
polyprotein3003
67.9K protein2002
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma5005
Snq2p0003
caspase-33003
Adenylate cyclase type 1 0303
Histone H2A.x3003
Caspase-71001
Spike glycoprotein0112
Replicase polyprotein 1ab0112
cytochrome P450 2D6 isoform 13003
cellular tumor antigen p53 isoform a2002
D(1A) dopamine receptor4004
vitamin D3 receptor isoform VDRA3003
potassium voltage-gated channel subfamily H member 2 isoform d5005
caspase-31001
histone deacetylase 9 isoform 31001
heat shock protein beta-12002
mitogen-activated protein kinase 12002
atrial natriuretic peptide receptor 2 precursor2002
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 14004
peripheral myelin protein 224004
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 17007
M-phase phosphoprotein 84004
histone acetyltransferase KAT2A isoform 14004
Gamma-aminobutyric acid receptor subunit pi7007
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0404
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Transmembrane protease serine 20112
Glutamate receptor ionotropic, NMDA 2D0101
Transient receptor potential cation channel subfamily V member 10202
Glutamate receptor ionotropic, NMDA 3B0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Bile salt export pump0202
5-hydroxytryptamine receptor 40808
Epidermal growth factor receptor0202
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Albumin0022
Albumin0033
Major prion protein0033
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p533003
Major prion protein0011
Integrin beta-31001
Cytochrome P450 1A20112
Tyrosine-protein kinase Fyn0202
Procathepsin L0112
Aldo-keto reductase family 1 member B10808
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40505
ATP-dependent translocase ABCB10608
Muscarinic acetylcholine receptor M10303
Muscarinic acetylcholine receptor M30303
Muscarinic acetylcholine receptor M40303
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 1A0303
5-hydroxytryptamine receptor 2C0303
Muscarinic acetylcholine receptor M50303
Muscarinic acetylcholine receptor M50606
Alpha-2A adrenergic receptor0606
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Cytochrome P450 2D60213
Muscarinic acetylcholine receptor M20303
Muscarinic acetylcholine receptor M10606
Cytochrome P450 2C9 0303
Polyunsaturated fatty acid lipoxygenase ALOX150303
Angiotensin-converting enzyme0303
D(2) dopamine receptor07111
5-hydroxytryptamine receptor 2A0303
Gamma-aminobutyric acid receptor subunit beta-17007
Alpha-1B adrenergic receptor0606
Sphingomyelin phosphodiesterase0101
Gamma-aminobutyric acid receptor subunit delta7007
Gamma-aminobutyric acid receptor subunit gamma-27007
Alpha-2C adrenergic receptor0606
D0505
D(3) dopamine receptor0505
5-hydroxytryptamine receptor 1A0606
Alpha-2B adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit alpha-57007
Gamma-aminobutyric acid receptor subunit alpha-37007
D(2) dopamine receptor0404
Muscarinic acetylcholine receptor M30505
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0608
D(4) dopamine receptor0519
D(1B) dopamine receptor0305
Adenylate cyclase type 30303
Alpha-2C adrenergic receptor0303
UDP-glucuronosyltransferase 1A40002
Alpha-2A adrenergic receptor0303
Gamma-aminobutyric acid receptor subunit gamma-17007
Gamma-aminobutyric acid receptor subunit alpha-27007
Alpha-1D adrenergic receptor0404
Sodium-dependent noradrenaline transporter 0808
Sodium-dependent dopamine transporter0303
Histamine H2 receptor0606
Alpha-1D adrenergic receptor0606
D(1B) dopamine receptor0505
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20303
Adenylate cyclase type 40303
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0707
5-hydroxytryptamine receptor 2C0808
Gamma-aminobutyric acid receptor subunit alpha-47007
Gamma-aminobutyric acid receptor subunit gamma-37007
5-hydroxytryptamine receptor 1B0505
Trypanothione reductase0404
Gamma-aminobutyric acid receptor subunit alpha-67007
D(4) dopamine receptor0505
5-hydroxytryptamine receptor 2B0303
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0606
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0202
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0306
5-hydroxytryptamine receptor 70202
Histamine H1 receptor0707
Mu-type opioid receptor08210
Glutamate receptor ionotropic, NMDA 1 0202
D(3) dopamine receptor07111
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0202
Adenylate cyclase type 80303
Proteasome subunit beta type-100001
Delta-type opioid receptor0404
Kappa-type opioid receptor0404
5-hydroxytryptamine receptor 2B0606
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0606
Histamine H2 receptor3004
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor4105
5-hydroxytryptamine receptor 60505
5-hydroxytryptamine receptor 70303
Cytochrome P450 2J20202
Gastrin/cholecystokinin type B receptor0202
Proteasome subunit alpha type-60012
D(2) dopamine receptor0506
Calmodulin 0112
Gamma-aminobutyric acid receptor subunit alpha-17007
Gamma-aminobutyric acid receptor subunit beta-37007
Gamma-aminobutyric acid receptor subunit beta-27007
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0404
Adenylate cyclase type 60303
Adenylate cyclase type 50303
Glutamate receptor ionotropic, NMDA 10101
Aldehyde oxidase0202
Potassium voltage-gated channel subfamily H member 20505
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, NMDA 2B0101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2C0101
Sodium channel protein type 9 subunit alpha0202
Glutamate receptor ionotropic, NMDA 2D0202
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0303
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
GABA theta subunit7007
Inositol hexakisphosphate kinase 12002
D0303
Sodium channel protein type 2 subunit alpha0202
Proteasome subunit beta type-70001
Ataxin-24004
Sigma non-opioid intracellular receptor 10808
Angiotensin-converting enzyme 2 0112
Gamma-aminobutyric acid receptor subunit epsilon7007
Sodium channel protein type 3 subunit alpha0202
Glutamate receptor ionotropic, NMDA 3A0202
Sodium channel protein type 11 subunit alpha0202
Sodium channel protein type 8 subunit alpha0202
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0202
cytochrome P450 2C9, partial2002
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
endonuclease IV3003
dopamine D1 receptor2002
pregnane X receptor1001
aldehyde dehydrogenase 1 family, member A14004
regulator of G-protein signaling 45005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
peripheral myelin protein 22 isoform 14004
flap endonuclease 13003
Glucocorticoid receptor0202
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 432002
Multidrug and toxin extrusion protein 10101
EWS/FLI fusion protein3003
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit beta0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Gamma-aminobutyric acid receptor subunit alpha-10112
Cytochrome P450 11B1, mitochondrial0101
Gamma-aminobutyric acid receptor subunit gamma-20112
Cytochrome P450 11B2, mitochondrial0101
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20112
Transporter0101
Luciferase2002
Nuclear receptor subfamily 1 group I member 20011
Delta-type opioid receptor0202
Delta-type opioid receptor0303
Mu-type opioid receptor0314
Kappa-type opioid receptor0202
Kappa-type opioid receptor0303
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Sigma non-opioid intracellular receptor 10303
Sigma non-opioid intracellular receptor 10303
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
glp-1 receptor, partial2002
15-lipoxygenase, partial4004
thyroid stimulating hormone receptor3003
nonstructural protein 12002
glucocerebrosidase1001
arylsulfatase A3003
cytochrome P450 2C9 precursor1001
transient receptor potential cation channel subfamily V member 11001
Cocaine esterase0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Cytochrome P450 3A40102
Beta-2 adrenergic receptor0202
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
UDP-glucuronosyltransferase 2B70102
Beta-1 adrenergic receptor0101
5-hydroxytryptamine receptor 3A0101
Beta-3 adrenergic receptor0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
Histamine H1 receptor0202
Sodium-dependent serotonin transporter0101
C-8 sterol isomerase0101
5-hydroxytryptamine receptor 2C 0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
Alpha-1B adrenergic receptor0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 40101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma intracellular receptor 20101
Zinc finger protein 6640101
Vesicular acetylcholine transporter0101
Transporter0101
Cholecystokinin receptor type A0101
Protease 0303
ATPase family AAA domain-containing protein 51001
Transient receptor potential cation channel subfamily V member 40101
Transient receptor potential cation channel subfamily V member 20101
Chain A, Beta-lactamase3003
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Caspase 6, apoptosis-related cysteine peptidase0001
apical membrane antigen 1, AMA12002
hypothetical protein, conserved1001
bromodomain adjacent to zinc finger domain 2B3003
pyruvate kinase1001
Bloom syndrome protein isoform 12002
lysosomal alpha-glucosidase preproprotein2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
estrogen receptor beta isoform 10101
importin subunit beta-1 isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
snurportin-12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)3003
muscleblind-like protein 1 isoform 13003
Rap guanine nucleotide exchange factor 31001
Cystathionine gamma-lyase0101
Solute carrier family 15 member 10101
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
interleukin 82002
hypoxia-inducible factor 1 alpha subunit1001
aryl hydrocarbon receptor2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
activating transcription factor 62002
polyunsaturated fatty acid lipoxygenase ALOX121001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
rac GTPase-activating protein 1 isoform a0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cannabinoid receptor 10202
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 20101
Prostaglandin G/H synthase 2 0101
Alpha-synuclein1203
Prostaglandin G/H synthase 1 0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
cytochrome P450 2C19 precursor1001
Inositol monophosphatase 11001
SMAD family member 21001
SMAD family member 31001
hemoglobin subunit beta1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
GTP-binding nuclear protein Ran isoform 11001
caspase-1 isoform alpha precursor1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
neuropeptide S receptor isoform A1001
ATP-dependent translocase ABCB10101
Quinolone resistance protein NorA0102
DNA topoisomerase 10101
ATP-dependent translocase ABCB10101
Nuclear receptor ROR-gamma1001
Chromaffin granule amine transporter0101
Caspase-71001
Synaptic vesicular amine transporter0101
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Solute carrier family 22 member 10101
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Acetylcholinesterase0101
PPM1D protein1001
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]