Page last updated: 2024-08-05 11:26:43
imidazotetrazine
Any organic heterobicyclic compound containing ortho-fused imidazole and tetrazine rings.
ChEBI ID: 72565
Members (1)
Member | Definition | Role |
---|---|---|
temozolomide | An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma. | temozolomide |
Research
Studies (5,827)
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 13 (0.22) | 18.7374 |
1990's | 99 (1.70) | 18.2507 |
2000's | 1,139 (19.55) | 29.6817 |
2010's | 3,154 (54.13) | 24.3611 |
2020's | 1,422 (24.40) | 2.80 |
Study Types
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 826 (13.73%) | 5.53% |
Reviews | 623 (10.36%) | 6.00% |
Case Studies | 541 (9.00%) | 4.05% |
Observational | 22 (0.37%) | 0.25% |
Other | 4,002 (66.54%) | 84.16% |