Exfoliation Glaucoma

Synonym
Pseudoexfoliation Of The Lens
Pseudoexfoliation Syndrome
Glaucoma Capsulare
Exfoliative Syndrome
Exfoliation Glaucoma
Pseudo-Exfoliation Syndrome

Excerpt	Reference
"Pseudoexfoliation syndrome is characterized by the presence of glycoprotein fibers in ocular and extraocular tissues, and often is associated with glaucoma."	( Hernandez, MR; Netland, PA; Streeten, BW; Ye, H, 1995)
"Since exfoliation glaucoma is known to demonstrate higher pressures than primary open-angle glaucoma on timolol maleate therapy alone, the authors wished to determine whether apraclonidine equalised the intraocular pressure (IOP) between these two glaucomas when added to timolol maleate."	( Konstas, AG; Maltezos, A; Mantziris, DA; Sine, CS; Stewart, WC, 1999)
"Pseudoexfoliation syndrome is one of the most frequent causes of open-angle glaucoma and is statistically significant associated with a high risk of hypertension, angina, myocardial infarction or stroke and retinal vein thrombosis."	( Grabner, G; Gruchmann, M; Hitzl, W; Mistlberger, A, 2001)
"Pseudoexfoliation syndrome is a risk factor in cataract surgery because of the increased weakness of zonular apparatus and reduced pupillary dilatation."	( Drolsum, L; Nicolaissen, B; Ringvold, A, 2007)
"Pseudoexfoliation syndrome is commonly associated with pseudoexfoliation glaucoma."	( Chakma, P; Chugh, N; Gupta, PC; Kaushik, S; Khera, A; Khullar, M; Pandav, SS; Raj, S; Ram, J; Seth, NG; Thattaruthody, F, 2019)
"Although pseudoexfoliation syndrome is a systemic syndrome, we can say that the emergence of iris dysfunction findings is parallel with the clinical observation of PXM."	( Yıldırım Biçer, G; Zor, KR, 2023)

Excerpt	Reference
"Eyes with pseudoexfoliation syndrome have a greater risk of intraoperative and postoperative complications."	( Baccara, F; Ravalico, G; Tognetto, D, 1994)

Excerpt	Reference
"Patients with exfoliation glaucoma and vascularized posterior synechiae who are receiving anticoagulation therapy are at increased risk for visually significant spontaneous hyphema after pupillary dilation."	( Greenfield, DS; Liebmann, JM; Ritch, R, 1999)
"Since exfoliation glaucoma is known to demonstrate higher pressures than primary open-angle glaucoma on timolol maleate therapy alone, the authors wished to determine whether apraclonidine equalised the intraocular pressure (IOP) between these two glaucomas when added to timolol maleate."	( Konstas, AG; Maltezos, A; Mantziris, DA; Sine, CS; Stewart, WC, 1999)
"Sixty-two consecutive patients (31 with exfoliation glaucoma and 31 with primary open angle glaucoma) chronically treated with timolol maleate twice daily were included in this trial."	( Bufidis, T; Hudgins, AG; Konstas, AG; Maltezos, A; Stewart, WC, 2000)
"On timolol monotherapy patients with exfoliation glaucoma had a higher mean IOP at 02:00, 06:00, 10:00, 14:00 and 22:00 hour time points as well as a higher maximum, minimum and range of IOP throughout the day compared with the primary open-angle glaucoma group (p < 0."	( Bufidis, T; Hudgins, AG; Konstas, AG; Maltezos, A; Stewart, WC, 2000)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.21)	23.3326
1990's	90 (19.23)	12.5806
2000's	167 (35.68)	18.1394
2010's	167 (35.68)	28.8240
2020's	43 (9.19)	9.53

Drug	Relationship Strength	Studies	Trials
carnitine	low	1	0
n(g),n(g')-dimethyl-l-arginine	low	4	0
cytosine	low	1	0
kynurenine	low	1	0
nitrates	medium	2	1
nitrites	low	2	0
thymine	low	1	0
xanthine	low	1	0
aminopropionitrile	low	2	0
acetazolamide	medium	7	1
apraclonidine	medium	3	1
betaxolol	medium	2	2
caffeine	low	1	0
clonidine	medium	3	1
cyclopentolate	low	2	0
diclofenac	medium	1	1
dipivefrin	low	1	0
erythrosine	medium	2	1
fluorouracil	medium	7	2
2-propanol	medium	130	8
memantine	low	1	0
mepivacaine	low	1	0
deoxyepinephrine	low	1	0
nitroglycerin	low	1	0
propranolol	low	1	0
tropicamide	medium	7	2
mitomycin	medium	34	7
prednisolone	medium	3	2
hydroxyproline	low	1	0
carbachol	low	2	0
prednisolone acetate	medium	3	2
prednisone	low	2	0
pilocarpine	medium	8	2
alanine	low	1	0
galactose	low	2	0
phenylephrine	medium	7	3
leucine	low	1	0
valine	low	1	0
tryptophan	low	1	0
arginine	low	4	0
triamcinolone acetonide	low	1	0
methylmethacrylate	low	1	0
quinoxalines	medium	6	3
tolonium chloride	low	1	0
thiophenes	medium	8	4
copper phthalocyanine	low	2	0
thiazoles	low	1	0
betamethasone	low	1	0
hematoxylin	low	1	0
malondialdehyde	medium	7	1
congo red	low	1	0
thorium dioxide	low	1	0
d-alpha tocopherol	medium	2	1
fluorescein	low	2	0
thioflavin t	low	1	0
argon	low	1	0
cadmium	low	1	0
gold	medium	1	1
phosphoric acid, trisodium salt	low	1	0
chlorine	low	1	0
nitrous acid	low	1	0
transferrin	low	1	0
timolol	medium	29	16
s-adenosylmethionine	low	1	0
acetylgalactosamine	low	1	0
propiconazole	low	3	0
fomesafen	low	1	0
bromfenac	medium	2	1
adenosine	low	1	0
potassium phosphate	low	1	0
glutathione disulfide	low	2	0
ibopamine	low	1	0
brinzolamide	medium	3	1
ketorolac tromethamine	medium	2	1
fibrinogen	low	2	0
homocysteine	low	27	0
vitamin b 6	low	3	0
mk 0663	low	1	0
n,n-dimethylarginine	low	4	0
glucuronic acid 3-sulfate	low	1	0
nepafenac	medium	1	1
moxifloxacin	low	1	0
symmetric dimethylarginine	low	1	0
biotin	low	1	0
atropine	low	1	0
erlotinib hydrochloride	low	1	0
cortisone	low	1	0
elastin	low	17	0
tretinoin	low	2	0
retinol	low	2	0
keratan sulfate	low	1	0
bromochloroacetic acid	low	1	0
isomethyleugenol	low	1	0
retinaldehyde	low	1	0
dermatan sulfate	low	2	0
icodextrin	low	1	0
dinoprostone	low	1	0
dinoprost	medium	6	1
coenzyme q10	medium	1	1
uf 021	medium	1	1
travoprost	medium	11	6
8-epi-prostaglandin f2alpha	low	2	0
15-keto-13,14-dihydroprostaglandin f2alpha	low	1	0
4-hydroxy-2-nonenal	low	1	0
dorzolamide	medium	8	4
bimatoprost	medium	13	6
cloprostenol	medium	17	9
latanoprost	medium	34	18
lysophosphatidic acid	low	2	0
lysophosphatidylcholines	low	2	0
sulfur	low	1	0
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	low	1	0
ammonium sulfate	low	1	0
selenium	low	2	0
mocetinostat	low	1	0
tafluprost	medium	2	1
brimonidine tartrate	medium	7	3
glanatec	low	1	0
losartan potassium	low	2	0
sepharose	low	1	0
indocyanine green	low	5	0
acid phosphatase	low	1	0
desmosine	low	1	0
angiotensinogen	low	1	0
endothelin-1	low	5	0
ubiquinone	medium	1	1
cardiovascular agents	low	1	0
interleukin-8	low	2	0
natriuretic peptide, brain	low	1	0
ascorbic acid	low	6	0
warfarin	low	1	0
epidermal growth factor	low	1	0
transforming growth factor beta	low	16	0
ar-12286	medium	1	1
vitamin b 12	low	8	0
lactoferrin	low	1	0
muramidase	low	1	0
chondroitin sulfates	low	1	0
exudates	low	1	0
deoxyguanosine	low	1	0
hypoxanthine	low	1	0
inosine	low	1	0
folic acid	low	8	0
neopterin	low	1	0
allopurinol	low	2	0
trypan blue	medium	7	1
alcian blue	low	1	0
eye	medium	34	1
2',7'-bis-(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester	medium	1	1

Protein Targets (967)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
RAR-related orphan receptor gamma	24	0	0	24
GLI family zinc finger 3	27	0	0	27
AR protein	40	0	0	40
aldehyde dehydrogenase 1 family, member A1	16	0	0	16
retinoic acid nuclear receptor alpha variant 1	27	0	0	27
retinoid X nuclear receptor alpha	19	0	0	19
estrogen nuclear receptor alpha	37	0	0	37
peroxisome proliferator-activated receptor delta	11	0	0	11
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	21	0	0	21
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Histone H2A.x	9	0	0	9
thyroid hormone receptor beta isoform a	12	0	0	12
heat shock protein beta-1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	19	0	0	19
lamin isoform A-delta10	19	0	0	19
Voltage-dependent calcium channel gamma-2 subunit	16	0	0	16
Glutamate receptor 2	16	0	0	16
Microtubule-associated protein tau	13	0	0	13
vitamin D3 receptor isoform VDRA	10	0	0	10
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	9	0	0	9
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	3	0	3
thioredoxin reductase	18	0	0	18
GALC protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
glucocorticoid receptor [Homo sapiens]	32	0	0	32
estrogen-related nuclear receptor alpha	33	0	0	33
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	4	0	4
arylsulfatase A	14	0	0	14
Carbonic anhydrase	0	4	0	4
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
Bloom syndrome protein isoform 1	11	0	0	11
geminin	18	0	0	18
peripheral myelin protein 22	11	0	0	11
survival motor neuron protein isoform d	9	0	0	9
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	7	4	3	14
ATP-binding cassette sub-family C member 3	0	20	0	20
Multidrug resistance-associated protein 4	0	20	0	22
Carbonic anhydrase	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	4	1	10
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	31	0	31
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 1	0	11	1	20
Carbonic anhydrase 2	0	12	3	22
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	2	1	3
Carbonic anhydrase 3	0	4	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	6	2	9
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	5	1	6
Cytochrome P450 2A6	0	2	1	3
Cytochrome P450 2C9	0	7	1	9
5-hydroxytryptamine receptor 2A	0	3	0	4
Androgen receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	7	4	3	14
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	7	4	3	14
Gamma-aminobutyric acid receptor subunit gamma-2	7	4	4	15
Gamma-aminobutyric acid receptor subunit alpha-5	7	4	3	14
Gamma-aminobutyric acid receptor subunit alpha-3	7	4	3	14
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	1	2
Carbonic anhydrase 4	0	10	1	15
Carbonic anhydrase 6	0	5	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	7	4	3	14
Gamma-aminobutyric acid receptor subunit alpha-2	7	4	3	14
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Adenosine receptor A1	0	4	1	6
Serum paraoxonase/arylesterase 1	0	1	0	1
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	7	4	3	14
Gamma-aminobutyric acid receptor subunit gamma-3	7	4	3	14
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	7	4	3	14
Adenosine receptor A2a	0	5	3	10
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	4	0	5
Cytochrome P450 2C19	0	4	1	5
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	6	1	12
Carbonic anhydrase	0	5	0	6
Kappa-type opioid receptor	0	2	0	2
Carbonic anhydrase 7	0	5	1	10
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	3	0	4
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	7	4	4	15
Gamma-aminobutyric acid receptor subunit beta-3	7	4	3	14
Gamma-aminobutyric acid receptor subunit beta-2	7	4	4	15
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	3	0	3
Mu-type opioid receptor	0	4	0	4
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	4
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	7	1	13
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	1	2
Renin	0	1	0	1
Carbonic anhydrase	0	3	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	6
GABA theta subunit	7	4	3	14
Canalicular multispecific organic anion transporter 1	0	18	0	18
Carbonic anhydrase 4	0	6	0	7
Carbonic anhydrase 15	0	5	0	7
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	8
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	4	3	14
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	4	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	6	1	12
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	12	0	0	12
NPYLR7B	0	0	1	1
IDH1	12	0	0	12
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
mitogen-activated protein kinase 1	7	0	0	7
flap endonuclease 1	8	0	0	8
nuclear receptor ROR-gamma isoform 1	10	0	0	10
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Purine nucleoside phosphorylase	0	1	0	2
Epidermal growth factor receptor	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	6	3	10
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	2	2
Adenosylhomocysteinase	0	1	0	3
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	4	6	12
Adenosine receptor A2b	0	1	1	4
Adenosine receptor A2b	0	4	3	8
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	3	3	9
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	1	0	2
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	4
Proton-coupled amino acid transporter 1	0	4	0	5
Adenosine deaminase	0	0	0	1
interleukin 8	4	0	0	4
TDP1 protein	26	0	0	26
thyroid stimulating hormone receptor	14	0	0	14
estrogen receptor 2 (ER beta)	11	0	0	11
progesterone receptor	16	0	0	16
transcriptional regulator ERG isoform 3	4	0	0	4
thyroid hormone receptor beta isoform 2	20	0	0	20
ras-related protein Rab-9A	2	0	0	2
Polyphenol oxidase 2	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Cellular tumor antigen p53	23	0	0	23
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	5
Purine nucleoside phosphorylase	0	0	1	1
TAR DNA-binding protein 43	5	0	0	5
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	1
ATAD5 protein, partial	5	0	0	5
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
glucocerebrosidase	3	0	0	3
DNA polymerase kappa isoform 1	8	0	0	8
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	4	0	4
Type-1 angiotensin II receptor	0	3	3	6
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
NFKB1 protein, partial	6	0	0	6
muscarinic acetylcholine receptor M1	7	0	0	7
Alpha-2A adrenergic receptor	0	6	5	12
Alpha-2B adrenergic receptor	0	6	4	11
Alpha-2C adrenergic receptor	0	6	5	12
Alpha-2B adrenergic receptor	0	4	1	5
Alpha-1D adrenergic receptor	0	7	3	11
Alpha-1A adrenergic receptor	0	4	5	10
Alpha-1B adrenergic receptor	0	3	4	8
ATP-dependent phosphofructokinase	12	0	0	12
Rho-associated protein kinase 2	0	2	0	2
Rho-associated protein kinase 1	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	12	0	0	12
GLS protein	8	0	0	8
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
chromobox protein homolog 1	16	0	0	16
DNA polymerase iota isoform a (long)	7	0	0	7
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	12	0	0	12
thioredoxin glutathione reductase	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Spike glycoprotein	10	0	0	10
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
pregnane X nuclear receptor	17	0	0	17
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	5	0	8
5-hydroxytryptamine receptor 4	0	6	0	6
Muscarinic acetylcholine receptor M2	0	8	5	17
Muscarinic acetylcholine receptor M4	0	6	3	12
Muscarinic acetylcholine receptor M1	0	6	2	13
Muscarinic acetylcholine receptor M3	0	6	2	12
Muscarinic acetylcholine receptor M4	0	6	1	11
Muscarinic acetylcholine receptor M5	0	6	1	11
Muscarinic acetylcholine receptor M5	0	7	3	13
Muscarinic acetylcholine receptor M2	0	6	1	12
Muscarinic acetylcholine receptor M1	0	8	6	18
Muscarinic acetylcholine receptor M1	0	1	2	4
Muscarinic acetylcholine receptor M3	0	7	4	14
5-hydroxytryptamine receptor 2C	0	6	1	7
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	4	0	0	5
5-hydroxytryptamine receptor 7	0	4	0	4
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	3	1	5
pregnane X receptor	8	0	0	8
farnesoid X nuclear receptor	11	0	0	11
aryl hydrocarbon receptor	13	0	0	13
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	10	2	17
Glycine receptor subunit alpha-1	0	10	0	10
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
ORF73	0	0	1	1
EWS/FLI fusion protein	8	0	0	8
cytochrome P450 2D6	13	0	0	13
Beta-1 adrenergic receptor	0	1	4	6
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-1 adrenergic receptor	0	5	3	8
Beta-1 adrenergic receptor	0	4	2	7
5-hydroxytryptamine receptor 1A	0	10	3	14
Beta-2 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	3	5
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, CARBONIC ANHYDRASE IV	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Prostaglandin G/H synthase 1	0	4	0	4
Prostaglandin G/H synthase 2	0	7	0	7
thyroid stimulating hormone receptor	11	0	0	11
Nuclear receptor ROR-gamma	4	1	1	6
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Potassium channel subfamily K member 2	0	0	1	1
Cholinesterase	0	3	0	3
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Acetylcholinesterase	0	3	0	3
Amine oxidase [flavin-containing] B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Guanine deaminase	0	2	0	2
peroxisome proliferator activated receptor gamma	14	0	0	14
thyrotropin-releasing hormone receptor	4	0	0	4
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
USP1 protein, partial	10	0	0	10
Vpr	2	0	0	2
Bile salt export pump	0	2	0	2
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	5	0	6
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Ferritin light chain	7	0	0	7
Chain A, Cruzipain	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-1B adrenergic receptor	0	5	1	6
Alpha-1A adrenergic receptor	0	2	2	4
D	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	4	1	5
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1B	0	8	0	8
Alpha-2B adrenergic receptor	0	0	0	2
D(4) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	5	2	7
Inositol monophosphatase 1	3	0	0	3
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Nischarin	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 2	0	2	0	2
Thromboxane A2 receptor	0	2	2	4
Prostaglandin E2 receptor EP1 subtype	0	4	3	7
Prostaglandin E2 receptor EP4 subtype	0	4	1	5
Prostaglandin F2-alpha receptor	0	4	3	7
Prostaglandin E2 receptor EP3 subtype	0	4	3	7
Prostaglandin E2 receptor EP2 subtype	0	4	1	5
Prostacyclin receptor	0	4	1	5
Prostaglandin D2 receptor	0	2	0	2
Luciferase	9	0	0	9
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	0	0	1
Beta-lactamase	0	1	0	1
Amyloid-beta precursor protein	1	6	0	7
Beta-lactamase	0	0	0	1
Beta-galactosidase	0	2	0	3
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	4	0	4
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
endonuclease IV	3	0	0	3
dopamine D1 receptor	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
peripheral myelin protein 22 isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	4	0	0	4
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Deoxycytidine kinase	0	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 2B	0	6	1	7
glp-1 receptor, partial	5	0	0	5
15-lipoxygenase, partial	4	0	0	4
Thrombopoietin	2	0	0	2
cellular tumor antigen p53 isoform a	3	0	0	3
D(1A) dopamine receptor	4	0	0	4
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Ataxin-2	9	0	0	9
phosphoglycerate kinase	2	0	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Chain A, Avidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain B, Avidin	0	0	1	1
67.9K protein	5	0	0	5
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Cytochrome c oxidase subunit 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	0	1	3
Albumin	0	1	3	4
Prostaglandin G/H synthase 1	0	2	0	2
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	3
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Solute carrier family 22 member 6	0	1	0	3
Prostaglandin G/H synthase 1	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Solute carrier family 22 member 2	0	0	0	3
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier family 22 member 7	0	0	0	2
Solute carrier family 22 member 8	0	0	0	2
Solute carrier organic anion transporter family member 2A1	0	2	0	4
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier family 22 member 7	0	0	0	2
SMAD family member 2	8	0	0	8
SMAD family member 3	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Androgen receptor	0	3	0	3
Endothelin-1 receptor	0	2	1	3
Serine/threonine-protein kinase B-raf	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Fumarate hydratase	3	0	0	3
hypothetical protein, conserved	2	0	0	2
G	7	0	0	7
polyprotein	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Flavin reductase (NADPH)	0	0	1	1
Inositol hexakisphosphate kinase 1	7	0	0	7
cytochrome P450 2C9, partial	7	0	0	7
large T antigen	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	2	0	2
Aromatase	0	1	0	1
ATPase family AAA domain-containing protein 5	7	0	0	7
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Alpha-synuclein	1	3	0	4
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Histone deacetylase 3	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Sterol O-acyltransferase 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Histone deacetylase 8	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Histone deacetylase 6	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Histone deacetylase 5	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Glutathione reductase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	1	0	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
PPM1D protein	4	0	0	4
alkaline phosphatase, intestinal	0	0	1	1
luciferase	1	0	0	1
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	3
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Smad3	3	0	0	3
Parkin	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
beta-2 adrenergic receptor	1	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	3	0	3
Phospholipase A-2-activating protein	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Lysophosphatidic acid receptor 6	0	0	1	1
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 1	0	0	2	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 5	0	0	1	1
Lysophosphatidic acid receptor 2	0	0	1	1
Lysophosphatidic acid receptor 3	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	3
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	2	0	3
Potassium channel subfamily K member 3	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Mitogen-activated protein kinase 14	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	2
DNA gyrase subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	4	2	6
Beta-3 adrenergic receptor	0	4	2	6
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Beta-2 adrenergic receptor	0	2	0	3
D(2) dopamine receptor	0	1	1	2
D(1A) dopamine receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Sodium-dependent serotonin transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Chain A, Cellular retinoic acid-binding protein 2	0	0	1	1
Caspase-7	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	2	0	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Thymidine phosphorylase	0	1	0	1
Microtubule-associated protein tau	0	2	0	2
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Plasma kallikrein	0	0	0	1
Myeloperoxidase	0	1	0	1
Stromelysin-1	0	1	0	1
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Ricin	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (468)

Protein Targets (967)

Exfoliation Glaucoma

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (468)

Drugs Studied (172)

Protein Targets (967)