An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions.
| Member | Definition | Class |
|---|
| 4-aminopyridine | An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis. | 4-aminopyridine |
| 4-aminopyridine-3-methanol | An aminopyridine that is 4-aminopyridine which is substituted by a hydroxymethyl group at position 3. It is a potassium channel blocker which restores axonal conduction after spinal cord injury. | 4-aminopyridine-3-methanol |
| 5-(4-phenylbutoxy)psoralen | A member of the class of psoralens that is psoralen substituted by a 4-phenylbutoxy group at position 5. It is a potent inhibitor of the voltage-gated potassium channel Kv1.3 (EC50 = 3 nM). | psora 4 |
| barium chloride | The inorganic dichloride salt of barium. | barium chloride |
| berberine | | berberine |
| ent-diltiazem | A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have R configuration. It is a cGMP-activated K+ channel blocker. | ent-diltiazem |
| methionine ethyl ester | An L-methionine derivative that is the ester obtained by formal condensation of the carboxy group of L-methionine with ethanol. | ethyl L-methioninate |
| nnc 55-0396 | The dihydrochloride salt of NNC 55-0396. It is a stable analogue of mibefradil and a highly selective T-type calcium channel blocker. | NNC 55-0396 dihydrochloride |
| NNC 55-0396 (free base) | | NNC 55-0396 (free base) |
| paxilline | An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. | paxilline |
| quinidine | A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. | quinidine |
| tetraethylammonium chloride | A quarternary ammonium chloride salt in which the cation has four ethyl substituents around the central nitrogen. | tetraethylammonium chloride |
| tolazamide | An N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus. | tolazamide |
| tolbutamide | An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position. | tolbutamide |
| uk 68798 | A tertiary amino compound that is N-ethyl-N-methylethanamine substituted by a 4-[(methylsulfonyl)amino]phenoxy and a 4-[(methylsulfonyl)amino]phenyl group at the terminal carbon atoms respectively. It is used as an anti-arrhythmia drug. | dofetilide |
| verruculogen | An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species. | verruculogen |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 67.9K protein | Vaccinia virus | Potency | 15.7824 | 2 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 26.0516 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 30.6344 | 1 | 8 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 9.9025 | 7 | 8 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.3278 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 2.6855 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 5.9137 | 1 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 57.4570 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 46.6008 | 1 | 3 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 30.6995 | 1 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 17.0157 | 2 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 6.4332 | 2 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 30.6694 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 19.7830 | 2 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 500.5912 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.6943 | 1 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 7.9402 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 19.7830 | 2 | 2 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 45.9131 | 2 | 4 |
| ClpP | Bacillus subtilis | Potency | 0.7079 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 0.0631 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 12.8878 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 19.0672 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 0.8750 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 13.3634 | 2 | 13 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.3134 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 10.1480 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 7.9739 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 14.9084 | 5 | 11 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 41.3800 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 31.5215 | 9 | 16 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 17.4584 | 1 | 9 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 18.3500 | 4 | 8 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 12.8878 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 13.5409 | 1 | 7 |
| geminin | Homo sapiens (human) | Potency | 2.0346 | 2 | 7 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 17.1256 | 2 | 6 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 15.9541 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 11.2698 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 14.4074 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.3539 | 4 | 7 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 1.3249 | 2 | 5 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 27.9362 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 12.8878 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 13.8154 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 22.7265 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 12.8878 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 2 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 11.9922 | 3 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.4897 | 2 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 5.9622 | 1 | 2 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 13.0060 | 1 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 15.8380 | 2 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 8.6583 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 5.2178 | 2 | 5 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 9.1148 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.9433 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.6483 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 49.3979 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 33.5520 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 10.5098 | 2 | 5 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 14.4750 | 2 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 49.1482 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.8078 | 2 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 38.1519 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.2589 | 1 | 1 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 10.3921 | 1 | 4 |
| PPM1D protein | Homo sapiens (human) | Potency | 10.4353 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 33.2686 | 3 | 5 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.6115 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 46.2122 | 2 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 52.3921 | 2 | 2 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 44.9069 | 1 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 44.9069 | 1 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 23.3507 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.9811 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.0265 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.0154 | 2 | 8 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 59.8771 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 56.2915 | 3 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 21.4376 | 2 | 9 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.2589 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.2589 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 26.9680 | 2 | 2 |