Page last updated: 2024-11-05

3-phenylenediamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,3-phenylenediamine : A phenylenediamine taht is benzene substituted at positions 1 and 3 with amino functions. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID7935
CHEMBL ID1595914
CHEBI ID8092
SCHEMBL ID16054
MeSH IDM0052185

Synonyms (103)

Synonym
(3-aminophenyl)-amine
m-fenylendiamin
1,3-diaminobenzene
c.i. 76025
nsc-4776
3-aminoaniline
direct brown gg
nsc4776
developer m
direct brown br
c.i. developer 11
developer h
developer c
m-aminoaniline
metaphenylenediamine
1,3-phenylenediamine
m-benzenediamine
108-45-2
developer 11
wln: zr cz
3-phenylenediamine
CHEBI:8092 ,
1,3-diamino-benzene
inchi=1/c6h8n2/c7-5-2-1-3-6(8)4-5/h1-4h,7-8h
benzene-1,3-diamine
NCGC00091145-01
ccris 1236
ai3-52607
einecs 203-584-7
meta-aminoaniline
m-fenylendiamin [czech]
meta-benzenediamine
m-phenylene diamine
ci developer 11
phenylenediamine, meta-
apco 2330
meta-diaminobenzene
nsc 4776
brn 0471357
benzene, 1,3-diamino-
hsdb 5384
1,3-benzenediamine
C02454
m-diaminobenzene
meta-phenylenediamine
m-phenylenediamine
m-phenylenediamine, flakes, 99%
AC-11132
AKOS000119108
NCGC00091145-03
NCGC00091145-02
NCGC00091145-04
dtxcid001137
tox21_300490
NCGC00254260-01
tox21_202106
cas-108-45-2
NCGC00259655-01
dtxsid4021137 ,
P1911
P1892
FT-0673748
oe624j2447 ,
m-phenylenediamine [un1673] [keep away from food]
unii-oe624j2447
4-13-00-00079 (beilstein handbook reference)
ec 203-584-7
FT-0606740
SCHEMBL16054
ci 76025
1,3-benzenediamine [hsdb]
ci-76025
m-phenylenediamine [inci]
rodol mpd
meta-phenylenediamine [iarc]
m-phenylenediamine [mi]
1,3-diaminobenzol
1,3-phenylene diamine
1,3-phenylendiamine
metaphenylene diamine
meta-phenylene diamine
m-phenylene-diamine
1,3 phenylenediamine
CHEMBL1595914
phenylenediamine, meta
phenylenediamine, m
W-108716
mfcd00007799
m-phenylenediamine, purum, >=99.0% (t)
m-phenylenediamine, technical, >=98.0% (nt)
F0001-0170
GS-6709
1,3-benzenediamine-d8
Q2410205
EN300-33904
STL194287
AMY40788
D92171
m-phenylenediamin
1,3 benzenodiamina
1,3 benzenediamine
1,3 benzendiammina
1,3 bencenodiamina

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" mPDA with or without plant activation was not toxic to the exposed cells."( Genotoxicity of m-phenylenediamine and 2-aminofluorene in Salmonella typhimurium and human lymphocytes with and without plant activation.
Anderson, D; Plewa, MJ; Wagner, ED; Yu, TW, 1995
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
phenylenediamineA benzene substituted with two amino groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (40)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency31.62280.125919.1169125.8920AID2549
Chain A, CruzipainTrypanosoma cruziPotency11.90470.002014.677939.8107AID1476; AID1478
RAR-related orphan receptor gammaMus musculus (house mouse)Potency1.70190.006038.004119,952.5996AID1159521
GLI family zinc finger 3Homo sapiens (human)Potency2.40400.000714.592883.7951AID1259369
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency33.95720.001022.650876.6163AID1224838
progesterone receptorHomo sapiens (human)Potency0.24040.000417.946075.1148AID1346795
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency18.59250.000214.376460.0339AID720692
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency30.26440.003041.611522,387.1992AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency0.00120.000817.505159.3239AID1159527
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.69470.001530.607315,848.9004AID1224841; AID1224848; AID1224849
aryl hydrocarbon receptorHomo sapiens (human)Potency51.61390.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency12.04850.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency39.52350.001628.015177.1139AID1224843; AID1259385
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency48.966219.739145.978464.9432AID1159509
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency43.38850.057821.109761.2679AID1159526; AID1159528
Histone H2A.xCricetulus griseus (Chinese hamster)Potency88.32770.039147.5451146.8240AID1224845
runt-related transcription factor 1 isoform AML1bHomo sapiens (human)Potency14.05500.02007.985839.8107AID504374; AID504375
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency32.53690.000323.4451159.6830AID743065; AID743067
core-binding factor subunit beta isoform 2Homo sapiens (human)Potency14.05500.02007.985839.8107AID504374; AID504375
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency47.30790.000627.21521,122.0200AID651741
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency31.62280.031610.279239.8107AID884; AID885
caspase-1 isoform alpha precursorHomo sapiens (human)Potency39.81070.000311.448431.6228AID900
lethal factor (plasmid)Bacillus anthracis str. A2012Potency12.58930.020010.786931.6228AID912
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Nuclear receptor ROR-gammaHomo sapiens (human)Potency2.37100.026622.448266.8242AID651802
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
GABA theta subunitRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (13)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
xenobiotic metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of glucose metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of steroid metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
intracellular receptor signaling pathwayNuclear receptor ROR-gammaHomo sapiens (human)
circadian regulation of gene expressionNuclear receptor ROR-gammaHomo sapiens (human)
cellular response to sterolNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of circadian rhythmNuclear receptor ROR-gammaHomo sapiens (human)
regulation of fat cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of DNA-templated transcriptionNuclear receptor ROR-gammaHomo sapiens (human)
adipose tissue developmentNuclear receptor ROR-gammaHomo sapiens (human)
T-helper 17 cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingNuclear receptor ROR-gammaHomo sapiens (human)
oxysterol bindingNuclear receptor ROR-gammaHomo sapiens (human)
zinc ion bindingNuclear receptor ROR-gammaHomo sapiens (human)
ligand-activated transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
sequence-specific double-stranded DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
nuclear receptor activityNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
nucleoplasmNuclear receptor ROR-gammaHomo sapiens (human)
nuclear bodyNuclear receptor ROR-gammaHomo sapiens (human)
chromatinNuclear receptor ROR-gammaHomo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (76)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (13.16)18.7374
1990's19 (25.00)18.2507
2000's13 (17.11)29.6817
2010's25 (32.89)24.3611
2020's9 (11.84)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 30.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index30.35 (24.57)
Research Supply Index4.41 (2.92)
Research Growth Index4.96 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (30.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (1.23%)4.05%
Observational0 (0.00%)0.25%
Other80 (98.77%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]