antirheumatic drug

A drug used to treat rheumatoid arthritis.

ChEBI ID: 35842

Members (38)

Member	Definition	Class
2-hydroxyacetanilide	A member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties.	2-acetamidophenol; 2'-Hydroxyacetanilide
acetovanillone	An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.	apocynin
alminoprofen	A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders.	alminoprofen
alvocidib	A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.	alvocidib
aminopropionitrile	An aminopropionitrile carrying an amino group at the beta-position.	beta-aminopropionitrile
ampiroxicam	A benzothiazine that is the 1-[(ethoxycarbonyl)oxy]ethyl ether of piroxicam. A prodrug for piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.	ampiroxicam
ampyrone	A pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole.	4-aminoantipyrine
as 605240	A quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.	(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
baricitinib	A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis.	baricitinib
beta-aminopropionitrile fumarate (2:1)	A fumarate salt prepared from beta-aminopropionitrile by reaction of one molecule of fumaric acid for every two molecules of beta-aminopropionitrile.	beta-aminopropionitrile hemifumarate
cenicriviroc	A member of the class of benzazocines that is (5Z)-1,2,3,4-tetrahydro-1-benzazocine which is substituted by a 2-methylpropyl, N-{4-[(S)-(1-propyl-1H-imidazol-5-yl)methanesulfinyl]phenyl}carboxamide and 4-(2-butoxyethoxy)phenyl groups at positions 1, 5 and 8, respectively. It is a potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis (NASH).	cenicriviroc
chloroquine	An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	chloroquine
cyclosporine	A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.	cyclosporin A
dipyrone	A pyrazole that is antiipyrine substituted at C-4 by a methyl(sulfomethyl)amino group, the sodium salt of which, metamizole sodium, was widely used as a powerful analgesic and antipyretic, but withdrawn from many markets from the 1970s due to a risk of causing risk of causing agranulocytosis.	metamizole
dipyrone	An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic.	metamizole sodium
flunoxaprofen	A monocarboxylic acid that is propionic acid substituted at position 2 by a 2-(4-chlorophenyl)-1,3-benzoxazol-5-yl group (the S-enantiomer). Although it was shown to be effective in treatment of rheumatoid arthritis and osteoarthritis, the clinical use of flunoxaprofen was discontinued due to possible hepatotoxic side-effects.	flunoxaprofen
hmr 1275	A hydrochloride salt resulting from the formal reaction of equimolar amounts of alvocidib and hydrogen chloride. A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.	alvocidib hydrochloride
hydroxychloroquine	An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.	hydroxychloroquine
isoxicam	A monocarboxylic acid amide that is piroxicam in which the pyrid-2-yl group is replaced by a 5-methyl-1,2-oxazol-3-yl group. A non-steroidal anti-inflammatory drug, it was withdrawn from the market in the 1980s following its association with cases of Stevens-Johnson syndrome.	isoxicam
levamisole	A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.	levamisole
madecassoside	A triterpenoid saponin that is a trisaccharide derivative of madecassic acid. Isolated from Centella asiatica, it exhibits anti-inflammatory, antioxidant and antirheumatic activities.	madecassoside
masitinib	A member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor.	masitinib
meclofenamate sodium anhydrous	A hydrate that is the monohydrate of the sodium salt of meclofenamic acid. It is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.	sodium meclofenamate monohydrate
meclofenamic acid	An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,6-dichloro-3-methylphenyl group. A non-steroidal anti-inflammatory drug, it is used as the sodium salt for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.	meclofenamic acid
mefenamic acid	An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.	mefenamic acid
methotrexate		methotrexate
mobic	A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.	meloxicam
pamapimod	A member of the class of pyridopyrimidines that is 8-methylpyrido[2,3-d]pyrimidin-7(8H)-one carrying additional (1,5-dihydroxypentan-3-yl)amino and 2,4-difluorophenoxy substituents at positions 2 and 6 respectively. It is a potent inhibitor of MAPK and is used for treatment of rheumatoid arthritis.	pamapimod
penicillamine	An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.	D-penicillamine
phenylbutazone	A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.	phenylbutazone
piroxicam	A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.	piroxicam
propionylcarnitine	An O-acylcarnitine compound having propanoyl as the acyl substituent.	O-propanoylcarnitine
salicylamide	The simplest member of the class of salicylamides derived from salicylic acid.	salicylamide
salicylsalicylic acid	A dimeric benzoate ester obtained by intermolecular condensation between the carboxy of one molecule of salicylic acid with the phenol group of a second. It is a prodrug for salycylic acid that is used for treatment of rheumatoid arthritis and osteoarthritis and also shows activity against type II diabetes.	salsalate
suprofen	An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group.	suprofen
suxibuzone	A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.	suxibuzone
tofacitinib	A pyrrolopyrimidine that is pyrrolo[2,3-d]pyrimidine substituted at position 4 by an N-methyl,N-(1-cyanoacetyl-4-methylpiperidin-3-yl)amino moiety. Used as its citrate salt to treat moderately to severely active rheumatoid arthritis.	tofacitinib
valdecoxib	A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke.	valdecoxib

Research

Studies (88,366)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	32,206 (36.45)	18.7374
1990's	13,749 (15.56)	18.2507
2000's	14,551 (16.47)	29.6817
2010's	18,565 (21.01)	24.3611
2020's	9,295 (10.52)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	10,488 (10.65%)	5.53%
Reviews	9,019 (9.16%)	6.00%
Case Studies	11,984 (12.17%)	4.05%
Observational	606 (0.62%)	0.25%
Other	66,338 (67.39%)	84.16%

Protein Targets (969)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	27.1044	1	8
15-lipoxygenase, partial	Homo sapiens (human)	Potency	16.9152	1	4
67.9K protein	Vaccinia virus	Potency	1.1974	2	8
acetylcholinesterase	Homo sapiens (human)	Potency	46.6255	2	5
acid sphingomyelinase	Homo sapiens (human)	Potency	31.6228	1	1
activating transcription factor 6	Homo sapiens (human)	Potency	3.2408	1	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	26.3649	1	10
alpha-galactosidase	Homo sapiens (human)	Potency	27.9709	1	3
Alpha-synuclein	Homo sapiens (human)	Potency	5.8048	1	1
AR protein	Homo sapiens (human)	Potency	19.8089	12	54
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	48.2920	2	7
arylsulfatase A	Homo sapiens (human)	Potency	0.3180	1	4
ATAD5 protein, partial	Homo sapiens (human)	Potency	20.3933	4	6
Ataxin-2	Homo sapiens (human)	Potency	16.0964	2	6
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	17.0427	2	5
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	16.7614	2	5
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	3.0131	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	6.6539	2	6
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	75.0594	1	2
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	5.4140	1	2
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	15.8489	1	1
caspase-3	Cricetulus griseus (Chinese hamster)	Potency	0.2660	1	1
caspase-3	Homo sapiens (human)	Potency	5.4140	1	2
Caspase-7	Cricetulus griseus (Chinese hamster)	Potency	0.2660	1	1
Caspase-7	Homo sapiens (human)	Potency	15.8489	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	18.3232	3	15
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	0.1000	2	2
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	25.5259	1	10
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	19.8461	2	5
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	34.3521	2	3
Chain A, HADH2 protein	Homo sapiens (human)	Potency	23.3291	2	5
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	62.3032	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	18.1976	2	9
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	12.5594	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	34.6152	1	5
Chain B, HADH2 protein	Homo sapiens (human)	Potency	23.3291	2	5
chromobox protein homolog 1	Homo sapiens (human)	Potency	79.0277	2	10
ClpP	Bacillus subtilis	Potency	23.7358	1	2
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	8.1548	1	2
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	14.8364	1	6
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	17.4432	1	8
cytochrome P450 2D6	Homo sapiens (human)	Potency	15.1653	1	4
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	25.1189	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	10.8126	2	12
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	16.4545	2	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	22.6711	1	6
D(1A) dopamine receptor	Homo sapiens (human)	Potency	0.9199	1	1
D(1A) dopamine receptor	Sus scrofa (pig)	Potency	14.6892	1	1
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	Potency	13.3025	1	5
DNA polymerase beta	Homo sapiens (human)	Potency	39.8107	1	1
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	31.6228	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	64.1546	1	5
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	46.7791	1	2
dopamine D1 receptor	Homo sapiens (human)	Potency	6.4052	1	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	15.3603	10	70
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	11.5325	2	10
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	18.1151	9	57
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	17.7789	1	13
EWS/FLI fusion protein	Homo sapiens (human)	Potency	17.8379	4	20
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	10.9107	4	10
flap endonuclease 1	Homo sapiens (human)	Potency	47.6708	1	3
Fumarate hydratase	Homo sapiens (human)	Potency	19.4030	1	2
G	Vesicular stomatitis virus	Potency	17.4432	1	8
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
GALC protein	Homo sapiens (human)	Potency	0.7079	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	10.8126	1	6
geminin	Homo sapiens (human)	Potency	15.9344	2	14
GLI family zinc finger 3	Homo sapiens (human)	Potency	12.7664	2	13
glp-1 receptor, partial	Homo sapiens (human)	Potency	2.5119	1	1
GLS protein	Homo sapiens (human)	Potency	21.6957	1	8
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	14.2104	4	13
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	17.4513	1	6
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	15.5669	2	22
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	22.7053	1	8
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	29.8493	2	2
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	53.8687	2	6
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	17.4432	1	8
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	14.4823	1	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	8.7699	2	6
IDH1	Homo sapiens (human)	Potency	9.8531	1	3
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	112.2020	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	17.4432	1	16
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	5.0119	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	0.1000	1	1
Integrin beta-3	Homo sapiens (human)	Potency	0.1000	1	1
Interferon beta	Homo sapiens (human)	Potency	12.1557	3	24
lamin isoform A-delta10	Homo sapiens (human)	Potency	9.6973	2	9
Luciferase	Photinus pyralis (common eastern firefly)	Potency	30.3756	3	14
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	56.2565	1	3
Microtubule-associated protein tau	Homo sapiens (human)	Potency	23.6387	2	10
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	19.9526	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	3.1623	1	1
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	43.4879	1	3
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	0.3162	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	0.0100	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	2.4852	1	4
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	7.3946	1	2
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	20.3730	3	23
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	8.1104	2	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	32.9572	1	2
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	84.1267	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	18.9966	1	2
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	14.1254	1	1
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	28.8189	2	23
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	58.6544	1	2
Parkin	Homo sapiens (human)	Potency	10.8383	2	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	23.9341	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	5.7764	2	7
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	16.2239	5	19
Peroxisome proliferator-activated receptor alpha	Homo sapiens (human)	Potency	35.4813	1	1
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	21.0290	4	9
phosphopantetheinyl transferase	Bacillus subtilis	Potency	55.8554	1	5
plasminogen precursor	Mus musculus (house mouse)	Potency	2.5119	1	1
polyprotein	Zika virus	Potency	19.4030	1	2
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	26.2000	1	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	18.8541	1	2
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	14.1254	1	1
PPM1D protein	Homo sapiens (human)	Potency	7.1556	1	8
pregnane X nuclear receptor	Homo sapiens (human)	Potency	28.6034	3	17
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	50.1187	1	2
progesterone receptor	Homo sapiens (human)	Potency	13.4684	3	8
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	2.5119	1	1
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	50.1187	1	1
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	18.8683	2	12
ras-related protein Rab-9A	Homo sapiens (human)	Potency	3.2643	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	21.8293	1	2
relaxin receptor 1 isoform 1	Homo sapiens (human)	Potency	12.5893	1	1
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	28.2955	3	16
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	11.5399	4	21
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	19.0975	3	3
SMAD family member 2	Homo sapiens (human)	Potency	22.6988	2	5
SMAD family member 3	Homo sapiens (human)	Potency	22.6988	2	5
Smad3	Homo sapiens (human)	Potency	0.3353	1	2
snurportin-1	Homo sapiens (human)	Potency	112.2020	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	21.6541	1	7
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	0.6051	1	3
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	19.6334	1	6
TDP1 protein	Homo sapiens (human)	Potency	7.2297	2	28
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	50.1187	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	19.9249	3	9
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	16.6152	3	16
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	39.8107	2	2
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	35.7168	1	2
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	4.5054	1	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	13.3025	1	5
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	2.5119	1	1
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	2.5119	1	1
USP1 protein, partial	Homo sapiens (human)	Potency	119.7498	2	5
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	11.6245	2	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	20.2566	5	15
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	41.1069	1	5
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	17.4513	1	6

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Homo sapiens (human)	IC50	10.0000	1	1
[Tau protein] kinase	Sus scrofa (pig)	IC50	0.3600	1	1
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	IC50	10.0000	1	1
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	IC50	0.0011	1	1
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	IC50	0.0146	2	2
5'-nucleotidase	Rattus norvegicus (Norway rat)	IC50	20.2000	1	1
6-phosphogluconate dehydrogenase, decarboxylating	Homo sapiens (human)	Ki	62.1500	1	4
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	IC50	77.0000	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	2.9270	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	Ki	2.9030	1	1
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	IC50	1.6000	1	1
Aldo-keto reductase family 1 member C1	Homo sapiens (human)	IC50	2.7425	3	4
Aldo-keto reductase family 1 member C1	Homo sapiens (human)	Ki	0.8100	1	1
Aldo-keto reductase family 1 member C2	Homo sapiens (human)	IC50	8.1500	2	3
Aldo-keto reductase family 1 member C2	Homo sapiens (human)	Ki	0.2200	1	1
Aldo-keto reductase family 1 member C3	Homo sapiens (human)	IC50	0.5380	3	4
Aldo-keto reductase family 1 member C3	Homo sapiens (human)	Ki	0.3000	1	1
Aldo-keto reductase family 1 member C4	Homo sapiens (human)	IC50	100.0000	2	3
Alkaline phosphatase, placental type	Homo sapiens (human)	IC50	400.0000	4	4
Alkaline phosphatase, tissue-nonspecific isozyme	Homo sapiens (human)	IC50	16.1525	4	4
Alkaline phosphatase, tissue-nonspecific isozyme	Homo sapiens (human)	Ki	16.0000	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	Bos taurus (cattle)	IC50	19.4060	5	5
Alkaline phosphatase, tissue-nonspecific isozyme	Bos taurus (cattle)	Ki	1.8100	1	1
Alpha-1A adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	9.3400	1	1
Alpha-1B adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	9.3400	1	1
Alpha-1D adrenergic receptor	Homo sapiens (human)	IC50	4.7720	1	1
Alpha-1D adrenergic receptor	Rattus norvegicus (Norway rat)	IC50	9.3400	1	1
Alpha-1D adrenergic receptor	Homo sapiens (human)	Ki	2.3460	1	1
Alpha-2A adrenergic receptor	Homo sapiens (human)	Ki	5.4108	1	2
Alpha-2B adrenergic receptor	Homo sapiens (human)	Ki	52.0332	1	2
Alpha-2C adrenergic receptor	Homo sapiens (human)	Ki	12.9244	1	2
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	165.8000	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	13.0000	2	2
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	9.9000	2	2
Androgen receptor	Homo sapiens (human)	IC50	1.0000	2	2
Angiotensin-converting enzyme 2	Homo sapiens (human)	IC50	6.2350	2	2
AP2-associated protein kinase 1	Homo sapiens (human)	IC50	0.0170	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	108.7632	2	10
ATP-binding cassette sub-family C member 3	Rattus norvegicus (Norway rat)	Ki	90.0000	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	3.0464	41	42
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	IC50	2.7500	4	4
ATP-dependent translocase ABCB1	Homo sapiens (human)	Ki	1.7183	6	6
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	Ki	3.5750	2	2
Beta-carbonic anhydrase 1	Mycobacterium tuberculosis H37Rv	Ki	12.9700	3	3
Beta-lactamase	Escherichia coli K-12	IC50	350.0000	1	1
Beta-secretase 1	Homo sapiens (human)	IC50	9.8500	2	2
Bifunctional dihydrofolate reductase-thymidylate synthase	Plasmodium falciparum K1	IC50	0.0840	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	Toxoplasma gondii	IC50	5.7614	29	39
Bifunctional dihydrofolate reductase-thymidylate synthase	Trypanosoma cruzi	IC50	0.1100	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	Leishmania major	Ki	0.0001	1	1
Bifunctional purine biosynthesis protein ATIC	Homo sapiens (human)	IC50	10.0050	2	2
Bifunctional purine biosynthesis protein ATIC	Homo sapiens (human)	Ki	0.8800	1	1
Bile salt export pump	Homo sapiens (human)	IC50	278.6570	8	27
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50	666.8667	1	3
Bile salt export pump	Homo sapiens (human)	Ki	9.5000	1	1
Bile salt export pump	Rattus norvegicus (Norway rat)	Ki	0.3000	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	24.6546	3	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	Ki	0.5000	1	1
C-C chemokine receptor type 2	Homo sapiens (human)	IC50	0.0059	2	2
C-C chemokine receptor type 5	Homo sapiens (human)	IC50	0.0030	1	1
C-C chemokine receptor type 5	Mus musculus (house mouse)	IC50	0.0002	1	1
C-C chemokine receptor type 7	Homo sapiens (human)	IC50	0.0031	1	1
Calcineurin subunit B type 1	Homo sapiens (human)	IC50	34.0000	1	1
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	IC50	505.0000	2	2
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	IC50	505.0000	2	2
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	IC50	505.0000	2	2
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	85.0808	5	12
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	Ki	11.2700	3	3
Canalicular multispecific organic anion transporter 1	Rattus norvegicus (Norway rat)	Ki	207.1920	5	5
Carbonic anhydrase	Candida albicans SC5314	Ki	0.7002	3	4
Carbonic anhydrase	Methanosarcina thermophila	Ki	0.1850	2	2
Carbonic anhydrase	Methanothermobacter thermautotrophicus str. Delta H	Ki	61.0000	1	1
Carbonic anhydrase	Saccharomyces cerevisiae S288C	Ki	0.6540	1	1
Carbonic anhydrase	Stylophora pistillata	Ki	5.7100	1	1
Carbonic anhydrase	Anopheles gambiae (African malaria mosquito)	Ki	0.1640	1	1
Carbonic anhydrase	Astrosclera willeyana	Ki	0.5170	1	1
Carbonic anhydrase	Cryptococcus neoformans var. grubii	Ki	0.7040	1	1
Carbonic anhydrase	Mycobacterium tuberculosis H37Rv	Ki	7.8100	1	1
Carbonic anhydrase	Nakaseomyces glabratus CBS 138	Ki	0.0970	1	1
Carbonic anhydrase	Stylophora pistillata	Ki	0.0287	2	2
Carbonic anhydrase	Sulfurihydrogenibium sp. YO3AOP1	Ki	0.0053	1	1
Carbonic anhydrase 1	Homo sapiens (human)	IC50	130.4833	4	7
Carbonic anhydrase 1	Homo sapiens (human)	Ki	50.7955	35	36
Carbonic anhydrase 12	Homo sapiens (human)	Ki	0.0130	5	5
Carbonic anhydrase 13	Homo sapiens (human)	Ki	0.4250	1	1
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	0.4250	1	1
Carbonic anhydrase 14	Homo sapiens (human)	Ki	0.1070	1	1
Carbonic anhydrase 15	Mus musculus (house mouse)	Ki	0.2347	2	3
Carbonic anhydrase 2	Homo sapiens (human)	IC50	101.2554	5	8
Carbonic anhydrase 2	Homo sapiens (human)	Ki	1.0789	41	42
Carbonic anhydrase 2	Mycobacterium tuberculosis H37Rv	Ki	0.6820	2	2
Carbonic anhydrase 3	Homo sapiens (human)	Ki	433.0000	2	2
Carbonic anhydrase 4	Bos taurus (cattle)	IC50	11.0126	3	5
Carbonic anhydrase 4	Bos taurus (cattle)	Ki	0.3400	2	2
Carbonic anhydrase 4	Homo sapiens (human)	Ki	1.0067	3	3
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	0.9120	1	1
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	0.0880	1	1
Carbonic anhydrase 6	Homo sapiens (human)	Ki	0.4455	3	4
Carbonic anhydrase 7	Homo sapiens (human)	Ki	3.9000	4	4
Carbonic anhydrase 9	Homo sapiens (human)	IC50	0.0270	2	2
Carbonic anhydrase 9	Homo sapiens (human)	Ki	2.7827	9	10
Carbonic anhydrase, alpha family	Hydrogenovibrio crunogenus XCL-2	Ki	0.5290	1	1
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	0.0200	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	0.0200	1	1
Casein kinase II subunit beta	Homo sapiens (human)	IC50	0.0200	1	1
CDGSH iron-sulfur domain-containing protein 1	Homo sapiens (human)	IC50	3.2600	1	1
CDK-activating kinase assembly factor MAT1	Homo sapiens (human)	IC50	0.5140	1	1
Chain A, Carbonic anhydrase II	Homo sapiens (human)	Ki	0.0430	1	1
Chain A, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform	Homo sapiens (human)	IC50	0.0080	1	2
Chain A, Protein (glycogen Phosphorylase)	Oryctolagus cuniculus (rabbit)	IC50	1.0000	1	1
Chain A, Tyrosine-protein kinase	Homo sapiens (human)	IC50	0.0116	1	4
Chain A, Tyrosine-protein kinase JAK2	Homo sapiens (human)	IC50	0.0116	1	2
Cyclic GMP-AMP synthase	Homo sapiens (human)	IC50	23.0000	1	1
Cyclin homolog	Herpesvirus saimiri (strain 11)	IC50	0.1850	1	4
Cyclin-A1	Homo sapiens (human)	IC50	0.7850	2	2
Cyclin-A1	Homo sapiens (human)	Ki	0.1900	1	1
Cyclin-A2	Homo sapiens (human)	IC50	0.3441	9	10
Cyclin-A2	Homo sapiens (human)	Ki	0.1900	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	0.1159	29	35
Cyclin-dependent kinase 1	Oryzias latipes (Japanese medaka)	IC50	0.2067	3	6
Cyclin-dependent kinase 1	Homo sapiens (human)	Ki	0.0550	2	2
Cyclin-dependent kinase 12	Homo sapiens (human)	IC50	1.3700	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	8.1751	37	44
Cyclin-dependent kinase 2	Homo sapiens (human)	Ki	0.1400	3	3
Cyclin-dependent kinase 4	Homo sapiens (human)	IC50	0.1589	27	34
Cyclin-dependent kinase 4	Homo sapiens (human)	Ki	0.0400	1	1
Cyclin-dependent kinase 5 activator 1	Homo sapiens (human)	IC50	0.1765	5	8
Cyclin-dependent kinase 6	Homo sapiens (human)	IC50	0.1572	6	9
Cyclin-dependent kinase 7	Homo sapiens (human)	IC50	0.3365	6	6
Cyclin-dependent kinase 9	Homo sapiens (human)	IC50	0.0209	17	17
Cyclin-dependent kinase 9	Homo sapiens (human)	Ki	0.0030	2	2
Cyclin-dependent-like kinase 5	Homo sapiens (human)	IC50	0.9935	9	12
Cyclin-G-associated kinase	Homo sapiens (human)	IC50	0.1360	1	1
Cyclin-H	Homo sapiens (human)	IC50	0.3413	3	3
Cyclin-K	Homo sapiens (human)	IC50	1.3700	1	1
Cyclin-T1	Homo sapiens (human)	IC50	0.0243	10	10
Cyclin-T1	Homo sapiens (human)	Ki	0.0030	1	1
Cyclooxygenase-2	Canis lupus familiaris (dog)	IC50	3.7900	1	1
Cystathionine gamma-lyase	Homo sapiens (human)	IC50	270.0000	1	1
Cysteine proteinase falcipain 2a	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	0.1100	2	2
Cytochrome c oxidase subunit 1	Ovis aries (sheep)	IC50	96.2000	1	1
Cytochrome c oxidase subunit 2	Homo sapiens (human)	IC50	1.1000	1	1
Cytochrome P450 11B1, mitochondrial	Bos taurus (cattle)	IC50	0.0012	2	5
Cytochrome P450 1A2	Homo sapiens (human)	IC50	64.5000	2	2
Cytochrome P450 2A6	Homo sapiens (human)	IC50	0.0120	1	1
Cytochrome P450 2C19	Homo sapiens (human)	IC50	12.0005	3	3
Cytochrome P450 2C8	Homo sapiens (human)	IC50	0.0014	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	41.9500	3	4
Cytochrome P450 2C9	Homo sapiens (human)	Ki	22.5667	3	3
Cytochrome P450 2D6	Homo sapiens (human)	IC50	43.0012	3	3
Cytochrome P450 2J2	Homo sapiens (human)	IC50	50.0000	1	2
Cytochrome P450 3A4	Homo sapiens (human)	IC50	155.2922	7	9
Cytochrome P450 3A4	Homo sapiens (human)	Ki	6.0550	2	4
Cytochrome P450 3A43	Homo sapiens (human)	IC50	2.0600	1	1
Cytochrome P450 3A43	Homo sapiens (human)	Ki	7.6000	1	2
Cytochrome P450 3A5	Homo sapiens (human)	IC50	2.0600	1	1
Cytochrome P450 3A5	Homo sapiens (human)	Ki	7.6000	1	2
Cytochrome P450 3A7	Homo sapiens (human)	IC50	2.0600	1	1
Cytochrome P450 3A7	Homo sapiens (human)	Ki	7.6000	1	2
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	IC50	0.0815	1	8
Delta carbonic anhydrase	Conticribra weissflogii	Ki	0.3780	1	1
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	IC50	0.0030	1	1
Delta-type opioid receptor	Mus musculus (house mouse)	Ki	27.0215	2	2
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0430	1	1
Dihydrofolate reductase	Enterococcus faecium	IC50	0.0014	1	1
Dihydrofolate reductase	Escherichia coli K-12	IC50	4.1688	24	34
Dihydrofolate reductase	Gallus gallus (chicken)	IC50	0.0545	2	2
Dihydrofolate reductase	Homo sapiens (human)	IC50	1.5079	80	94
Dihydrofolate reductase	Lacticaseibacillus casei	IC50	0.0138	29	30
Dihydrofolate reductase	Mus musculus (house mouse)	IC50	0.0331	11	11
Dihydrofolate reductase	Mycobacterium tuberculosis H37Rv	IC50	0.0174	3	3
Dihydrofolate reductase	Pneumocystis carinii	IC50	0.0717	12	13
Dihydrofolate reductase	Rattus norvegicus (Norway rat)	IC50	0.0047	10	11
Dihydrofolate reductase	Escherichia coli K-12	Ki	34.5460	5	5
Dihydrofolate reductase	Homo sapiens (human)	Ki	6.3684	12	12
Dihydrofolate reductase	Lacticaseibacillus casei	Ki	0.0000	1	1
Dihydrofolate reductase	Mus musculus (house mouse)	Ki	0.2167	17	18
Dihydrofolate reductase	Pneumocystis carinii	Ki	0.0000	1	1
Dihydrofolate reductase	Staphylococcus aureus	Ki	0.0005	2	2
Dihydrofolate reductase	Bacillus anthracis	IC50	0.0136	1	2
Dihydrofolate reductase	Bos taurus (cattle)	IC50	611.0529	13	13
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	IC50	50.0000	1	1
DNA ligase	Tequatrovirus T4	IC50	823.0000	2	4
DNA ligase 1	Homo sapiens (human)	IC50	823.0000	2	4
DNA ligase A	Mycobacterium tuberculosis H37Rv	IC50	823.0000	2	4
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	IC50	0.0815	1	8
Dual specificity protein kinase CLK1	Homo sapiens (human)	IC50	0.0700	1	1
Dual specificity protein kinase CLK1	Mus musculus (house mouse)	IC50	1.3000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	IC50	0.8150	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	IC50	0.3000	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	IC50	0.0800	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	IC50	0.1000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	5.4809	6	13
Estrogen receptor 1	Homo sapiens (human)	IC50	50.0000	1	2
Fatty acid-binding protein, intestinal	Homo sapiens (human)	Ki	8.9000	1	1
Fatty acid-binding protein, liver	Rattus norvegicus (Norway rat)	Ki	0.3175	2	2
Fatty-acid amide hydrolase 1	Mus musculus (house mouse)	IC50	0.0800	1	1
fMet-Leu-Phe receptor	Homo sapiens (human)	IC50	7.6500	2	2
Folate receptor alpha	Homo sapiens (human)	IC50	0.2262	4	4
Folate receptor beta	Homo sapiens (human)	IC50	0.1585	4	4
Folylpolyglutamate synthase, mitochondrial	Homo sapiens (human)	IC50	3.2000	1	1
Folylpolyglutamate synthase, mitochondrial	Mus musculus (house mouse)	Ki	166.0000	1	1
G1/S-specific cyclin-D1	Homo sapiens (human)	IC50	0.1837	18	25
G1/S-specific cyclin-D2	Homo sapiens (human)	IC50	0.1000	2	2
G1/S-specific cyclin-D3	Homo sapiens (human)	IC50	0.1983	3	3
G1/S-specific cyclin-E1	Homo sapiens (human)	IC50	15.2146	16	22
G1/S-specific cyclin-E2	Homo sapiens (human)	IC50	55.3000	6	6
G2/mitotic-specific cyclin-B	Marthasterias glacialis (spiny starfish)	IC50	0.2067	3	6
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	0.1464	20	26
G2/mitotic-specific cyclin-B2	Homo sapiens (human)	IC50	0.1571	7	7
G2/mitotic-specific cyclin-B3	Homo sapiens (human)	IC50	0.1571	7	7
Genome polyprotein	Zika virus	Ki	92.3000	1	1
Glucose-6-phosphate 1-dehydrogenase	Homo sapiens (human)	Ki	74.4500	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	Homo sapiens (human)	IC50	80.0000	1	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	Plasmodium berghei	IC50	67.6667	3	3
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50	0.0006	1	1
Glutathione reductase, mitochondrial	Homo sapiens (human)	Ki	6.1000	1	1
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus (rabbit)	IC50	1.2000	1	1
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	IC50	0.5250	2	2
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	2.9888	4	4
Glycogen synthase kinase-3 beta	Rattus norvegicus (Norway rat)	IC50	0.1850	1	4
Glycogen synthase kinase-3 beta	Sus scrofa (pig)	IC50	0.3600	1	1
Histidine decarboxylase	Rattus norvegicus (Norway rat)	IC50	0.0014	1	1
Histidine-rich protein PFHRP-II	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	396,967.5905	13	13
Ileal sodium/bile acid cotransporter	Homo sapiens (human)	Ki	24.0000	1	1
Insulin receptor	Homo sapiens (human)	IC50	10.0000	1	1
Integrase	Human immunodeficiency virus 1	IC50	100.0000	2	2
Interleukin-2	Mus musculus (house mouse)	IC50	0.0050	1	1
Intestinal-type alkaline phosphatase	Bos taurus (cattle)	IC50	171.7220	5	5
Intestinal-type alkaline phosphatase	Homo sapiens (human)	IC50	205.0420	5	5
Kappa-type opioid receptor	Rattus norvegicus (Norway rat)	IC50	0.0030	1	1
La-related protein 7	Homo sapiens (human)	Ki	0.0030	1	1
large T antigen	Betapolyomavirus macacae	IC50	6.2000	1	1
Lysyl oxidase homolog 2	Homo sapiens (human)	IC50	0.5650	13	13
Lysyl oxidase homolog 2	Mus musculus (house mouse)	IC50	0.1280	1	1
Lysyl oxidase homolog 2	Rattus norvegicus (Norway rat)	IC50	0.1270	1	1
Lysyl oxidase homolog 3	Homo sapiens (human)	IC50	0.2400	2	2
Lysyl oxidase homolog 4	Homo sapiens (human)	IC50	100.0000	1	1
Malate dehydrogenase, cytoplasmic	Homo sapiens (human)	IC50	225.0000	1	1
MAP kinase-activated protein kinase 2	Homo sapiens (human)	IC50	10.0000	2	2
MAP kinase-activated protein kinase 5	Homo sapiens (human)	IC50	10.0000	1	1
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50	0.2000	1	1
Mitogen-activated protein kinase 1	Homo sapiens (human)	IC50	3.1440	1	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	IC50	10.0000	1	1
Mitogen-activated protein kinase 12	Homo sapiens (human)	IC50	10.0000	1	1
Mitogen-activated protein kinase 13	Homo sapiens (human)	IC50	10.0000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	3.3427	3	3
Mitogen-activated protein kinase 3	Homo sapiens (human)	IC50	16.0000	1	1
Mitogen-activated protein kinase 8	Homo sapiens (human)	IC50	7.7100	2	2
MO15-related protein kinase Pfmrk	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	150.0000	1	1
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	IC50	0.0030	1	1
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0430	1	1
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	54.0000	1	1
Multidrug resistance associated protein	Homo sapiens (human)	Ki	1,200.0000	1	1
Multidrug resistance-associated protein 1	Homo sapiens (human)	IC50	3.5082	10	10
Multidrug resistance-associated protein 1	Homo sapiens (human)	Ki	5.0000	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	129.7667	1	9
Muscarinic acetylcholine receptor M1	Homo sapiens (human)	Ki	12.3042	1	2
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	IC50	2.9510	1	1
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	Ki	3.6183	2	3
Muscarinic acetylcholine receptor M3	Homo sapiens (human)	Ki	4.0488	1	2
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	Ki	5.6249	1	2
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	Ki	20.9151	1	2
Myc proto-oncogene protein	Homo sapiens (human)	IC50	403.0000	1	1
Myeloperoxidase	Homo sapiens (human)	IC50	1.5950	2	2
NACHT, LRR and PYD domains-containing protein 3	Mus musculus (house mouse)	IC50	25.0000	1	1
Nicotinate phosphoribosyltransferase	Homo sapiens (human)	Ki	0.0001	1	2
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	GI50	1.5240	1	1
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	IC50	6.3900	44	64
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Ki	0.0063	5	5
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	Homo sapiens (human)	IC50	35.8790	2	2
nuclear receptor coactivator 3 isoform a	Homo sapiens (human)	IC50	18.0450	2	2
Peptidyl-prolyl cis-trans isomerase A	Homo sapiens (human)	IC50	0.0252	12	12
Peptidyl-prolyl cis-trans isomerase A	Homo sapiens (human)	Ki	0.0645	8	8
Peptidyl-prolyl cis-trans isomerase B	Homo sapiens (human)	IC50	0.0088	1	1
Peptidyl-prolyl cis-trans isomerase D	Homo sapiens (human)	IC50	0.0036	1	1
Peptidyl-prolyl cis-trans isomerase D	Homo sapiens (human)	Ki	0.0129	4	4
Peptidyl-prolyl cis-trans isomerase FKBP1A	Homo sapiens (human)	Ki	0.0200	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1B	Homo sapiens (human)	Ki	0.0060	1	1
Peptidyl-prolyl cis-trans isomerase FKBP4	Homo sapiens (human)	IC50	0.0160	1	1
Peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus (Norway rat)	Ki	0.0060	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	IC50	1.7830	3	6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	IC50	0.6676	2	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	IC50	0.1876	2	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	IC50	0.0947	4	7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Mus musculus (house mouse)	IC50	0.5700	1	1
Phosphoethanolamine N-methyltransferase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	554.0000	1	1
Phospholipase A-2-activating protein	Homo sapiens (human)	IC50	5.0000	1	1
Polyunsaturated fatty acid 5-lipoxygenase	Rattus norvegicus (Norway rat)	IC50	49.3333	3	3
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	2.5030	4	4
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	Ki	4.3914	2	3
Procathepsin L	Homo sapiens (human)	IC50	5.4700	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	53.5489	14	25
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	94.6225	7	12
Prostaglandin G/H synthase 1	Bos taurus (cattle)	IC50	65.0000	1	2
Prostaglandin G/H synthase 1	Rattus norvegicus (Norway rat)	IC50	3.8250	4	4
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	25.8391	23	31
Prostaglandin G/H synthase 2	Mus musculus (house mouse)	IC50	0.1619	4	6
Prostaglandin G/H synthase 2	Bos taurus (cattle)	IC50	65.0000	1	2
Prostaglandin G/H synthase 2	Rattus norvegicus (Norway rat)	IC50	3.8250	4	4
Protein kinase C alpha type	Homo sapiens (human)	IC50	7.4667	6	6
Protein kinase C alpha type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein kinase C beta type	Homo sapiens (human)	IC50	19.0000	4	4
Protein kinase C beta type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein kinase C delta type	Homo sapiens (human)	IC50	7.9725	4	4
Protein kinase C delta type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein kinase C epsilon type	Homo sapiens (human)	IC50	7.8700	4	4
Protein kinase C epsilon type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein kinase C eta type	Homo sapiens (human)	IC50	19.0000	4	4
Protein kinase C eta type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein kinase C gamma type	Homo sapiens (human)	IC50	10.3333	3	3
Protein kinase C gamma type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein kinase C iota type	Homo sapiens (human)	IC50	10.3333	3	3
Protein kinase C theta type	Homo sapiens (human)	IC50	10.3333	3	3
Protein kinase C theta type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein kinase C zeta type	Homo sapiens (human)	IC50	10.3333	3	3
Protein kinase C zeta type	Rattus norvegicus (Norway rat)	IC50	14.0000	1	1
Protein-arginine deiminase type-4	Homo sapiens (human)	IC50	10,000.0000	1	1
Protein-lysine 6-oxidase	Bos taurus (cattle)	IC50	1.9953	1	1
Protein-lysine 6-oxidase	Homo sapiens (human)	IC50	33.7000	3	3
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	34.0000	1	1
Proton-coupled folate transporter	Homo sapiens (human)	IC50	0.1208	2	2
Pteridine reductase 1	Leishmania major	Ki	0.1095	2	2
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	IC50	10.0000	1	1
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	1.8280	2	9
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	IC50	0.0815	1	8
Reduced folate transporter	Homo sapiens (human)	IC50	0.0120	2	2
Reduced folate transporter	Homo sapiens (human)	Ki	3.5000	1	1
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	IC50	5.4700	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	5.4700	1	1
Replicase polyprotein 1ab	Human coronavirus 229E	IC50	5.4700	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	602.8450	4	6
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	1,794.7350	2	2
Reverse transcriptase/RNaseH	Human immunodeficiency virus 1	IC50	0.4550	1	1
Rho-associated protein kinase 2	Homo sapiens (human)	IC50	3.4000	2	2
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	IC50	10.0000	1	1
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	IC50	10.0000	1	1
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	IC50	10.0000	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	IC50	1.5000	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus (rabbit)	IC50	62.0000	1	1
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase D1	Homo sapiens (human)	IC50	10.3333	3	3
Serine/threonine-protein kinase D3	Homo sapiens (human)	IC50	10.3333	3	3
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50	0.2700	1	1
Serine/threonine-protein kinase Sgk1	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	IC50	5.7600	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Homo sapiens (human)	IC50	0.1830	1	1
Sigma intracellular receptor 2	Rattus norvegicus (Norway rat)	IC50	0.0143	1	1
Sigma intracellular receptor 2	Homo sapiens (human)	Ki	0.7506	1	2
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	0.1027	1	2
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	2.9270	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	2.9030	1	1
Sodium/bile acid cotransporter	Homo sapiens (human)	IC50	1.0000	1	1
Solute carrier family 22 member 11	Homo sapiens (human)	Ki	107.8000	1	1
Solute carrier family 22 member 20	Mus musculus (house mouse)	Ki	599.7800	1	2
Solute carrier family 22 member 6	Homo sapiens (human)	IC50	20.5000	1	1
Solute carrier family 22 member 6	Homo sapiens (human)	Ki	19.8000	1	1
Solute carrier family 22 member 6	Mus musculus (house mouse)	Ki	896.1255	1	2
Solute carrier family 22 member 6	Rattus norvegicus (Norway rat)	Ki	52.0000	1	1
Solute carrier family 22 member 8	Homo sapiens (human)	Ki	413.1933	2	3
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	IC50	0.9500	5	5
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	Ki	0.4845	4	4
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	IC50	1.3000	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	Ki	1.2000	1	1
Solute carrier organic anion transporter family member 2B1	Homo sapiens (human)	IC50	37.0000	1	1
Solute carrier organic anion transporter family member 2B1	Homo sapiens (human)	Ki	36.0000	1	1
Spike glycoprotein	Betacoronavirus England 1	IC50	5.4700	1	1
Spike glycoprotein	Severe acute respiratory syndrome coronavirus 2	IC50	3.5800	2	2
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	IC50	5.4700	1	1
Substance-K receptor	Homo sapiens (human)	IC50	4.1390	1	1
Substance-K receptor	Homo sapiens (human)	Ki	1.3800	1	1
Substance-P receptor	Cavia porcellus (domestic guinea pig)	IC50	29.0000	1	1
Succinyl-diaminopimelate desuccinylase	Haemophilus influenzae Rd KW20	IC50	50.0000	1	1
Thymidylate synthase	Escherichia coli K-12	IC50	11.4303	3	12
Thymidylate synthase	Homo sapiens (human)	IC50	33.6082	12	21
Thymidylate synthase	Lacticaseibacillus casei	IC50	158.1000	10	10
Thymidylate synthase	Mus musculus (house mouse)	IC50	20.0000	2	2
Thymidylate synthase	Homo sapiens (human)	Ki	0.6000	1	1
Thymidylate synthase	Mus musculus (house mouse)	Ki	45.0000	1	1
Thymidylate synthase	Escherichia coli	IC50	60.6000	3	3
Thymidylate synthase	Escherichia coli LF82	IC50	18.0000	1	1
Toll-like receptor 4	Homo sapiens (human)	IC50	1.0400	1	1
Toll-like receptor 7	Homo sapiens (human)	IC50	3.4000	3	3
Toll-like receptor 9	Homo sapiens (human)	IC50	0.1100	1	1
transactivating tegument protein VP16 [Human herpesvirus 1]	Human alphaherpesvirus 1 (Herpes simplex virus type 1)	IC50	35.8790	2	2
Transcription factor SOX-18	Mus musculus (house mouse)	IC50	163.0000	2	2
Transient receptor potential cation channel subfamily M member 2	Homo sapiens (human)	IC50	124.0000	1	1
Transmembrane protease serine 2	Homo sapiens (human)	IC50	5.4700	1	1
Transthyretin	Homo sapiens (human)	Ki	0.0026	1	1
Trifunctional purine biosynthetic protein adenosine-3	Homo sapiens (human)	IC50	10.0050	2	2
Trifunctional purine biosynthetic protein adenosine-3	Mus musculus (house mouse)	IC50	20.0000	2	2
Tyrosine-protein kinase Blk	Homo sapiens (human)	IC50	0.0815	1	8
Tyrosine-protein kinase BTK	Homo sapiens (human)	IC50	0.0835	2	9
Tyrosine-protein kinase CSK	Homo sapiens (human)	IC50	10.0000	1	1
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	IC50	1.7224	2	9
Tyrosine-protein kinase JAK1	Homo sapiens (human)	GI50	0.0953	1	1
Tyrosine-protein kinase JAK1	Homo sapiens (human)	IC50	0.0608	85	105
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Ki	0.0007	6	6
Tyrosine-protein kinase JAK2	Homo sapiens (human)	GI50	1.1570	1	1
Tyrosine-protein kinase JAK2	Homo sapiens (human)	IC50	0.1899	91	115
Tyrosine-protein kinase JAK2	Rattus norvegicus (Norway rat)	IC50	3.5700	2	2
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Ki	0.0008	5	5
Tyrosine-protein kinase JAK3	Homo sapiens (human)	GI50	0.5030	1	1
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC50	0.2721	69	86
Tyrosine-protein kinase JAK3	Mus musculus (house mouse)	IC50	0.6640	5	5
Tyrosine-protein kinase JAK3	Rattus norvegicus (Norway rat)	IC50	1.2000	1	1
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Ki	0.0004	6	6
Tyrosine-protein kinase Lck	Homo sapiens (human)	IC50	3.8960	5	5
Tyrosine-protein kinase Tec	Homo sapiens (human)	IC50	0.0815	1	8
Tyrosine-protein kinase TXK	Homo sapiens (human)	IC50	0.0815	1	8
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	IC50	50.0000	1	1
UDP-glucuronosyltransferase 1-6	Homo sapiens (human)	IC50	211.8333	1	6
UDP-glucuronosyltransferase 1A1	Homo sapiens (human)	IC50	211.8333	1	6
UDP-glucuronosyltransferase 1A4	Homo sapiens (human)	IC50	211.8333	1	6
UDP-glucuronosyltransferase 2B10	Homo sapiens (human)	IC50	211.8333	1	6
UDP-glucuronosyltransferase 2B7	Homo sapiens (human)	IC50	211.8333	1	6
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	0.4000	1	1
Vitamin K-dependent protein C	Homo sapiens (human)	IC50	0.1429	3	14

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	4
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	5
5-hydroxytryptamine receptor 2A	Mus musculus (house mouse)	EC50	5.3360	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	17.6600	4	10
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	2	5
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	5
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	4
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	4
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	3
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	4
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	18.2784	3	11
Activin receptor type-1	Homo sapiens (human)	Kd	17.0889	3	9
Activin receptor type-1B	Homo sapiens (human)	Kd	18.8889	3	9
Activin receptor type-2A	Homo sapiens (human)	Kd	8.6200	2	5
Activin receptor type-2B	Homo sapiens (human)	Kd	17.2000	3	9
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	4
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	4
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	3
Adenosine kinase	Homo sapiens (human)	Kd	23.1102	1	4
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	5
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	4
ADP/ATP translocase 3	Homo sapiens (human)	Kd	22.5015	1	4
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	6.2680	2	5
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	10.0000	2	5
Angiotensin-converting enzyme 2	Homo sapiens (human)	EC50	5.4411	1	9
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	2	5
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	9.3348	8	14
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	2
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent translocase ABCB1	Homo sapiens (human)	EC50	25.7799	8	8
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	17.1000	4	10
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	10.0000	2	5
Aurora kinase A	Homo sapiens (human)	Kd	18.8889	3	9
Aurora kinase B	Homo sapiens (human)	Kd	18.2295	3	11
Aurora kinase C	Homo sapiens (human)	Kd	10.0000	2	5
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	2	5
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	4
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	12.4869	5	11
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	18.8889	3	9
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	20.0643	2	7
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	18.8889	3	9
Breakpoint cluster region protein	Homo sapiens (human)	Kd	22.5195	1	4
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	EC50	1.7500	1	1
Calcium-dependent protein kinase 1	Plasmodium falciparum K1	EC50	0.0680	1	1
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	10.0000	1	3
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	5.0295	3	6
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	12.2559	4	10
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	6.8667	3	6
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	8.3200	2	5
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	15.7143	3	7
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	4.7000	3	6
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	7.8833	3	6
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	15.4612	3	10
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	14.7603	3	9
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	14.6511	3	9
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	15.9552	3	9
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	18.8889	3	9
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	5
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	2	5
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	3
Carbonic anhydrase 2	Homo sapiens (human)	EC50	0.0010	1	1
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	20.4429	2	7
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	8.4800	2	5
Casein kinase I isoform delta	Homo sapiens (human)	Kd	20.0000	3	10
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	15.5018	5	11
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	14.7726	3	9
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	17.0265	3	10
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	18.8889	3	9
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	5
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	16.2869	3	9
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	7.7667	1	3
cell division cycle 42 (GTP binding protein, 25kDa), partial	Homo sapiens (human)	EC50	30.0000	2	2
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	20.0000	3	10
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	5
Chain B, DIHYDROFOLATE REDUCTASE	Escherichia coli	Kd	0.1344	1	5
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	1
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	4
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	10.5910	3	9
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	22.8790	1	4
Cyclin-dependent kinase 10	Homo sapiens (human)	Kd	30.0000	1	3
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	2	5
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	2	5
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	22.5392	1	4
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	16.0349	2	7
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	6.0440	2	5
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	6.7767	1	3
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	12.2152	4	10
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	13.4407	3	9
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	6.4400	2	5
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	6.0228	2	5
Cyclin-dependent kinase 2	Homo sapiens (human)	EC50	0.0010	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	12.2637	4	10
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	16.7578	3	9
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	16.0012	3	10
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	23.3148	1	4
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	15.0721	3	10
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	6.0480	2	5
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	13.3355	3	9
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	3
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	10.0000	1	3
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	10.0000	1	3
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	18.3345	2	6
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	12.0370	4	10
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	8.5455	9	15
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	4
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	4
Cytochrome P450 3A4	Homo sapiens (human)	Kd	0.0130	1	1
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	2	5
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	5
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	5
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	5
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	3	7
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	3
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	4
Dihydrofolate reductase	Escherichia coli K-12	EC50	0.0010	1	1
Dihydrofolate reductase	Escherichia coli K-12	Kd	0.3062	10	10
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	14.8869	3	9
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	3
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	4
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	4
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	4
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	8.0667	1	3
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	17.0429	3	10
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	20.0000	3	10
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	17.9111	3	9
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	14.6143	3	7
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	20.0257	2	7
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	18.8889	3	9
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	3
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	12.6378	4	10
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	15.5800	4	10
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	13.8000	4	9
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	15.7143	3	7
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	13.3333	3	6
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	18.8889	3	9
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	15.8553	2	7
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	10.0280	3	6
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	10.0000	1	3
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	4
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	2	5
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	4
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	3
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	4
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	16.5375	3	8
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	17.2222	3	9
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	5.8200	2	5
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	18.8889	3	9
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	17.9545	4	11
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	10.0000	2	5
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	18.8889	3	9
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	8.3600	2	5
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	7.2833	3	6
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	18.8889	3	9
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	20.0000	3	10
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	18.8889	3	9
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	21.4286	2	7
Epidermal growth factor receptor	Homo sapiens (human)	Kd	9.0678	23	60
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	13.2128	4	10
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)	Kd	30.0000	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	8.5438	2	6
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	3
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	4
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	4
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	18.8889	3	9
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	2	5
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	4	10
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	10.0000	2	5
Focal adhesion kinase 1	Homo sapiens (human)	Kd	18.8889	3	9
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	1	3
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	22.7302	1	4
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	6
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	23.3922	1	4
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	23.0303	1	4
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	13.7301	3	9
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	15.2200	3	10
glycogen synthase kinase-3 beta isoform 1	Homo sapiens (human)	EC50	300.0000	1	2
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	4
GTP-binding protein (rab7)	Canis lupus familiaris (dog)	EC50	30.0000	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	2
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	4
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	16.2500	5	16
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	17.5000	3	8
High mobility group protein B1	Homo sapiens (human)	Kd	0.2620	2	2
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	8.9333	1	3
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	8.0667	1	3
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	8.1000	1	3
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	7.3333	1	3
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	3
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	1	3
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	3
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	17.3556	3	9
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	3
Insulin receptor	Homo sapiens (human)	Kd	18.8889	3	9
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	2	5
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	18.8889	3	9
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	4
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	8.0800	2	5
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	20.0771	2	7
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	20.0000	3	10
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	20.2143	2	7
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	4.1417	2	6
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	6.8800	2	5
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	7.0667	1	3
LIM domain kinase 1	Homo sapiens (human)	Kd	18.8889	3	9
LIM domain kinase 2	Homo sapiens (human)	Kd	20.9091	3	11
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	4
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	5.1215	2	5
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	21.4286	2	7
Major prion protein	Homo sapiens (human)	EC50	4.0000	1	1
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	18.8889	3	9
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	18.8889	3	9
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	5
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	4.9833	3	6
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	13.4318	3	9
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	17.5000	3	8
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	7.7484	15	38
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	18.8889	3	9
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	3
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	3
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	20.0000	3	10
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	3
Midasin	Homo sapiens (human)	Kd	30.0000	1	4
Misshapen-like kinase 1	Homo sapiens (human)	Kd	16.2600	2	5
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	18.8889	3	9
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	14.6398	5	11
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	15.4764	5	11
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	2	5
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	15.4548	5	11
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	16.7400	3	9
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	18.8889	3	9
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	2	5
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	2	5
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	18.1240	3	10
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	14.7255	5	11
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	16.6693	5	12
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	17.4130	2	7
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	8.0800	2	5
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	18.8889	3	9
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	10.0000	1	3
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	20.8714	2	7
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	17.8633	3	9
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	21.4143	2	7
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	18.8889	3	9
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	18.8889	3	9
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	21.4286	2	7
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	7.6333	1	3
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	8.2800	2	5
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	17.4000	3	9
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	19.2699	2	7
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	17.6667	3	9
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	18.8889	3	9
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	18.8889	3	9
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	3
mu-type opioid receptor isoform MOR-1	Homo sapiens (human)	EC50	92.5900	1	1
Multidrug resistance-associated protein 1	Homo sapiens (human)	EC50	1.7000	1	1
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	4
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	5
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	10.0000	2	5
Myosin light chain kinase 3	Homo sapiens (human)	Kd	21.4286	2	7
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	2	5
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	2
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	18.8889	3	9
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	4
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	5
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	2	5
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	2	5
Myotonin-protein kinase	Homo sapiens (human)	Kd	4.5000	2	5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	4
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	9.3705	4	10
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	EC50	0.4467	3	3
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	9.6556	6	14
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	2	5
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	2	5
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	13.3880	4	10
Nuclear receptor subfamily 4 group A member 2	Homo sapiens (human)	EC50	48.5000	2	2
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	4
Nucleoside diphosphate kinase B	Homo sapiens (human)	Kd	30.0000	1	1
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	3
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	4
Peptidyl-prolyl cis-trans isomerase A	Homo sapiens (human)	Kd	0.6225	11	11
Peptidyl-prolyl cis-trans isomerase B	Homo sapiens (human)	Kd	0.0098	1	1
Peptidyl-prolyl cis-trans isomerase D	Homo sapiens (human)	Kd	0.0215	2	2
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	10.0000	1	3
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	20.0047	1	3
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	4
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	4
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	3
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	2	5
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	7.5333	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	12	34
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	1	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	2	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	16.2450	2	7
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	17.0727	4	11
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	6.8800	2	5
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	7.1850	2	5
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	14.9724	3	9
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	5
Procathepsin L	Homo sapiens (human)	EC50	5.4411	1	9
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	3
Protein kinase C alpha type	Homo sapiens (human)	Kd	24.0338	1	5
Protein kinase C beta type	Homo sapiens (human)	Kd	29.0810	1	4
Protein kinase C delta type	Homo sapiens (human)	Kd	7.2281	3	9
Protein kinase C epsilon type	Homo sapiens (human)	Kd	6.1520	2	5
Protein kinase C eta type	Homo sapiens (human)	Kd	6.1400	2	5
Protein kinase C iota type	Homo sapiens (human)	Kd	21.4286	2	7
Protein kinase C theta type	Homo sapiens (human)	Kd	16.7444	3	9
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	2
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	18.1222	3	9
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	18.8889	3	9
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	12.2136	7	20
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	2	5
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	17.8778	3	9
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	4
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	5
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	4
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	18.8889	3	9
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	18.8889	3	9
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	18.8889	3	9
Rac1 protein	Homo sapiens (human)	EC50	30.0000	2	2
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	5
ras protein, partial	Homo sapiens (human)	EC50	30.0000	2	2
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	6
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	3
Ras-related protein Rab-2A	Canis lupus familiaris (dog)	EC50	30.0000	1	1
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	4
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	8.2400	2	5
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	9.7333	1	3
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	8.3333	1	3
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	5
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	18.8889	3	9
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	4
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	3
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	11.6278	13	36
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	EC50	5.4411	1	9
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	Kd	220.0000	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	EC50	5.4411	1	9
Replicase polyprotein 1ab	Human coronavirus 229E	EC50	5.4411	1	9
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	5.4411	1	9
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	EC50	5.4411	1	9
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	10.6974	2	7
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	10.8076	2	7
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	6.8833	1	3
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	5.0933	1	3
Riboflavin-binding protein	Gallus gallus (chicken)	Kd	2.1000	1	1
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	10.6985	5	14
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	5.1917	6	12
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	16.1300	4	10
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	13.5167	6	15
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	14.8000	6	15
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	11.7760	6	15
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	18.9500	2	6
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	22.6172	1	4
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	4
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	5
Septin-9	Homo sapiens (human)	Kd	22.5210	1	4
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	8.8200	2	5
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	6.4833	3	6
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	17.5000	3	8
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	16.7400	4	10
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	8.5000	1	3
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	6.6800	2	5
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	6.8167	1	3
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	8.5000	3	6
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	15.7143	3	7
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	4
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	4
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	15.1286	5	14
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	6.2080	2	5
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	13.7240	3	9
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	13.4663	3	9
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	6.1800	2	5
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	2.0368	3	6
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	21.2501	2	8
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	6.6760	1	3
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	12.9723	3	9
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	17.0022	3	9
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	20.6605	3	10
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	5.7330	4	10
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	14.6077	3	9
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	22.5000	2	8
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	15.4855	5	11
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	17.5000	3	8
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	14.2940	4	10
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	8.8843	4	7
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	4.3840	2	5
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	7.3333	1	3
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	13.3333	3	6
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	18.3182	4	11
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	12.4167	3	6
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	7.2333	1	3
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	3
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	21.4286	2	7
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	18.8889	3	9
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	17.9244	2	8
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	20.0357	2	7
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	16.3441	2	7
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	16.0599	2	7
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	6.0220	2	5
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	2	5
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	20.0900	2	9
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	6.8233	1	3
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	20.9143	2	7
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	6.6877	1	3
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	22.5000	2	8
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	4
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	4
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	3
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	EC50	30.0000	1	1
Spike glycoprotein	Betacoronavirus England 1	EC50	5.4411	1	9
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	EC50	5.4411	1	9
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	5
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	5
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	3
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	18.8889	3	9
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	4
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	3
Stromelysin-1	Homo sapiens (human)	Kd	25,000.0000	1	1
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	3
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	3
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	5
TGF-beta receptor type-1	Homo sapiens (human)	Kd	18.8889	3	9
TGF-beta receptor type-2	Homo sapiens (human)	Kd	17.9111	3	9
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	5
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	18.8889	3	9
Transient receptor potential cation channel subfamily A member 1	Homo sapiens (human)	EC50	31.1986	2	3
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	3
Transmembrane protease serine 2	Homo sapiens (human)	EC50	5.4411	1	9
Transthyretin	Homo sapiens (human)	Kd	0.4800	1	1
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	10.0000	1	2
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	4
Tyrosine-protein kinase ABL1	Homo sapiens (human)	EC50	0.0010	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	7.0034	23	63
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	14.4960	3	9
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	8.0300	2	5
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	18.8889	3	9
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	18.8889	3	9
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	18.8889	3	9
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	18.8889	3	9
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	11.7733	3	6
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	15.1930	3	10
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	16.8044	3	9
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	19.0690	3	10
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	2	5
Tyrosine-protein kinase JAK1	Homo sapiens (human)	EC50	0.0683	6	6
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	14.2860	6	14
Tyrosine-protein kinase JAK2	Homo sapiens (human)	EC50	0.1266	5	5
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	9.5014	5	9
Tyrosine-protein kinase JAK3	Homo sapiens (human)	EC50	0.0165	2	2
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	3.0865	4	7
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	15.8101	3	9
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	17.7846	3	9
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	8.7200	2	5
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	10.0000	2	5
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	2	5
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	7.4000	2	5
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	6.5600	2	5
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	18.8889	3	9
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	20.0000	3	10
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	10.0000	2	5
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	19.0570	3	10
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	2	5
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	4
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	3
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	4
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	22.5195	1	4
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	3
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	10.0000	2	5
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	10.0000	2	5
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	2	5
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	4
Wee1-like protein kinase	Homo sapiens (human)	Kd	20.0000	3	10
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	3

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	ID50	0.0500	1	1
ATP-binding cassette sub-family C member 11	Homo sapiens (human)	Km	957.0000	1	1
ATP-binding cassette sub-family C member 3	Rattus norvegicus (Norway rat)	Km	8.1000	2	2
ATP-dependent translocase ABCB1	Homo sapiens (human)	Activity	9.0333	3	3
ATP-dependent translocase ABCB1	Homo sapiens (human)	Km	4.1233	3	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	Km	2,560.0000	3	3
Canalicular multispecific organic anion transporter 1	Rattus norvegicus (Norway rat)	Km	296.0000	1	1
Carbonic anhydrase	Brucella suis 1330	Kinact	0.0190	1	1
Cyclin-A1	Homo sapiens (human)	ID50	0.1000	1	1
Cyclin-A2	Homo sapiens (human)	ID50	0.1000	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	ID50	0.4000	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	Cell cycle	0.0210	10	10
Cyclin-dependent kinase 2	Homo sapiens (human)	ID50	0.1000	1	1
Cyclin-dependent kinase 4	Homo sapiens (human)	ID50	0.4000	1	1
Dihydrofolate reductase	Homo sapiens (human)	IC80	1.4400	1	1
Dihydrofolate reductase	Lacticaseibacillus casei	ID50	0.0130	5	5
Dihydrofolate reductase	Mus musculus (house mouse)	ID50	0.0171	6	6
fMet-Leu-Phe receptor	Homo sapiens (human)	IC20	3.6000	1	1
Folylpolyglutamate synthase, mitochondrial	Mus musculus (house mouse)	Concentration	47.0000	1	2
Folylpolyglutamate synthase, mitochondrial	Homo sapiens (human)	Km	71.3333	3	3
Folylpolyglutamate synthase, mitochondrial	Mus musculus (house mouse)	Km	165.0000	1	1
Folylpolyglutamate synthase, mitochondrial	Homo sapiens (human)	Vmax	0.8200	1	1
G1/S-specific cyclin-D1	Homo sapiens (human)	ID50	0.4000	1	1
G1/S-specific cyclin-D2	Homo sapiens (human)	ID50	0.4000	1	1
G1/S-specific cyclin-D3	Homo sapiens (human)	ID50	0.4000	1	1
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	ID50	0.4000	1	1
G2/mitotic-specific cyclin-B2	Homo sapiens (human)	ID50	0.4000	1	1
G2/mitotic-specific cyclin-B3	Homo sapiens (human)	ID50	0.4000	1	1
Histidine-rich protein PFHRP-II	Plasmodium falciparum (malaria parasite P. falciparum)	Inhibition	55.0000	1	1
Multidrug resistance associated protein	Homo sapiens (human)	Km	768.6667	3	3
Multidrug resistance-associated protein 1	Homo sapiens (human)	Km	1,540.0000	2	2
Multidrug resistance-associated protein 4	Homo sapiens (human)	Km	1,300.0000	1	1
Non-lysosomal glucosylceramidase	Mus musculus (house mouse)	Activity	11.0000	1	1
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	fIC50	0.0322	4	4
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	INH	0.0880	1	2
scavenger receptor class B member 1 isoform 1	Mus musculus (house mouse)	AbsAC40_uM	35.0000	1	1
Solute carrier family 22 member 11	Homo sapiens (human)	Km	17.8000	1	1
Solute carrier family 22 member 6	Homo sapiens (human)	Km	553.8000	1	1
Solute carrier family 22 member 8	Homo sapiens (human)	Km	16.0000	2	2
Solute carrier organic anion transporter family member 1A3	Rattus norvegicus (Norway rat)	Km	1.6333	3	3
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	Km	24.7000	1	1
Tyrosine-protein kinase JAK1	Homo sapiens (human)	fIC50	0.0543	9	9
Tyrosine-protein kinase JAK1	Homo sapiens (human)	INH	0.0178	2	4
Tyrosine-protein kinase JAK2	Homo sapiens (human)	fIC50	0.0538	6	6
Tyrosine-protein kinase JAK2	Homo sapiens (human)	INH	0.3600	2	4
Tyrosine-protein kinase JAK3	Homo sapiens (human)	fIC50	0.0750	2	2
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC90	0.1600	1	1
Tyrosine-protein kinase JAK3	Homo sapiens (human)	INH	0.0915	1	2
UDP-glucuronosyltransferase 1A9	Homo sapiens (human)	Km	37.0000	1	1
UDP-glucuronosyltransferase 2B7	Homo sapiens (human)	Km	202.0000	1	1

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antirheumatic drug

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Studies (88,366)

Study Types

Protein Targets (969)

Potency Measurements

Inhibition Measurements

Activation Measurements

Other Measurements