An agonist that binds to and activates glycine receptors
ChEBI ID: 64589
| Member | Definition | Class |
|---|---|---|
| sarcosine | A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine. | sarcosine zwitterion; sarcosine |
| taurine | An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension. | taurine zwitterion; taurine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,348 (29.92) | 18.7374 |
| 1990's | 2,146 (19.18) | 18.2507 |
| 2000's | 2,470 (22.08) | 29.6817 |
| 2010's | 2,475 (22.12) | 24.3611 |
| 2020's | 750 (6.70) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 499 (4.21%) | 5.53% |
| Reviews | 816 (6.89%) | 6.00% |
| Case Studies | 112 (0.95%) | 4.05% |
| Observational | 13 (0.11%) | 0.25% |
| Other | 10,411 (87.85%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.0007 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.2920 | 2 | 3 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 30.1025 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0107 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0126 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 28.3716 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 100.0000 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 35.7177 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 26.2127 | 7 | 7 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.9350 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.1836 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 8.8030 | 2 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.0890 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 31.7236 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 41.4924 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 11.8566 | 3 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 17.3107 | 3 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.9953 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 31.8334 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 3.7578 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.1865 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 28.3716 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 33.7756 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.9953 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.9953 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 13.2849 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 4,850.0000 | 1 | 2 |
| Sodium- and chloride-dependent glycine transporter 1 | Homo sapiens (human) | IC50 | 91.0000 | 1 | 1 |
| Sodium- and chloride-dependent taurine transporter | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |