Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Reference |
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| "Since septic shock is characterized by lowered arterial pressure and vasodilatation it is concluded that effects of dopamine on capacitance and resistance vessels make this drug more suitable." | ( Carlet, J; Regnier, B; Safran, D; Teisseire, B, 1979) |
| "Septic shock is frequently associated with acute renal failure." | ( Ali, MM; Duarte, RR; Grace, BW; Nayak, P; Sayegh, NY, 1992) |
| "Septic shock is a major complication during the treatment of intense care patients." | ( Hartung, T; Tiegs, G; Wendel, A, 1992) |
| "Septic shock is a complex event with activation of many inflammatory pathways." | ( Weinberg, JR, 1992) |
| "Septic shock is an acute impairment of tissue perfusion, characterized by hypotension, low systemic vascular resistance and increased blood levels of lactate." | ( Ruokonen, E; Takala, J, 1992) |
| "Septic shock is characterized by hypoperfusion and tissue energy defects." | ( Astiz, M; Fried, J; Rackow, E; Tuchschmidt, J, 1992) |
| "Septic shock is characterized by a decreased vascular tone and a depressed myocardial function." | ( Cosyns, B; Moulart, D; Preiser, JC; Vincent, JL, 1991) |
| "Septic shock is a life-threatening condition that results from exposure to bacterial endotoxin." | ( Adams, J; Griffith, OW; Gross, SS; Jubran, A; Kilbourn, RG; Levi, R; Lodato, RF, 1990) |
| "Treatment of septic shock is a persistent dilemma." | ( Hackshaw, KV; Parker, GA; Roberts, JW, 1990) |
| "Septic shock is a common clinical problem in the intensive care setting." | ( Boyd, JL; Chernow, B; Stanford, GG, 1989) |
| "Septic shock is known to involve increased metabolism of arachidonic acid and generation of certain eicosanoids." | ( Ashton, SH; Cook, JA; Galbraith, RM; Halushka, PV; Watt, GH; Wise, WC, 1989) |
| "Septic shock is a distinct clinical entity with an overall mortality of 30% to 40%." | ( Berringer, R; Harwood-Nuss, AL, 1985) |
| "Septic shock is associated with increased metabolism of arachidonic acid to thromboxane A2 (TxA2) and prostacyclin (PGI2)." | ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985) |
| "Septic shock is a common emergency, most often caused by gram-negative bacteremia." | ( Eskridge, RA, 1983) |
| "Septic shock is an emergency that is best treated by establishing priorities beforehand." | ( Ellenbogen, C, 1982) |
| "Septic shock is known to induce progressive myocardial dysfunction characterized hemodynamically by a decrease in cardiac output and a rise in ventricular filling pressures." | ( Depeursinge, F; Perret, C, 1981) |
| "Septic shock is a life-threatening condition that results from exposure to bacterial endotoxin." | ( Chang, CH; Chang, JP; Lin, PJ, 1994) |
| "Septic shock is associated with high mortality." | ( Higa, EM; McMurtry, IF; Niederberger, M; Raynolds, M; Schrier, RW; Weigert, AL, 1995) |
| "Gram-negative septic shock is associated with severe hypotension and autonomic cardiovascular dysfunction." | ( Cox, C; DeAsla, R; DeKing, D; DeLong, DJ; Goldstein, B; Kempski, MH; Lund, N; Stair, D; Tipton, RB; Woolf, PD, 1995) |
| "Because septic shock is a dynamic and evolving condition, different strategies may be needed at different stages in the pathogenesis of sepsis." | ( Cohen, J; Lynn, WA, 1995) |
| "Septic shock is the major cause of treatment-related death in patients with acute myelogenous leukaemia (AML) undergoing intensive chemotherapy." | ( Kienast, J; Mesters, RM; Ostermann, H; Rothenburger, M; van de Loo, J, 1994) |
| "Later stages of septic shock are characterized by hypotension and decreased myocardial performance." | ( Chelly, FD; Cromeens, DM; Griffith, OW; Kilbourn, RG, 1994) |
| "Septic shock is characterized by systemic vasodilation and an impaired reactivity to vasoconstrictor agents." | ( Cañas, P; Jorge, P; Landín, L; Liste, D; Lorente, JA; Renes, E, 1994) |
| "Hypotension in septic shock is a reflection of unregulated nitric oxide (NO) production and vascular smooth muscle guanylyl cyclase activation." | ( Francis, S; Keaney, JF; Loscalzo, J; Loscalzo, JF; Puyana, JC; Stamler, JS, 1994) |
| "Early septic shock is characterized by fever, increased cardiac output, decreased systemic vascular resistance, and dilation of higher-order arterioles in peripheral tissues, such as skeletal muscle." | ( Arden, WA; Derbin, M; Greenberg, RN; Gross, DR; Oremus, R; Pofahl, W; Schwartz, RW, 1993) |
| "Severe septic shock is associated with an imbalance between oxygen demand and oxygen supply (DO2) in the presence of an impaired oxygen extraction." | ( Bakker, J; Vincent, JL, 1993) |
| "Septic shock is characterized by coagulation activation and fibrinolysis activation and inhibition." | ( de Pablo, R; García-Avello, A; García-Frade, LJ; Landín, L; Lorente, JA; Renes, E; Torrado, C, 1993) |
| "Septic shock is a major cause of hospital deaths despite modern intensive therapy." | ( Brady, AJ, 1995) |
| "Septic shock is a cytokine-mediated process typically caused by a severe underlying infection." | ( Haber, E; Hsieh, CM; Lee, ME; Lee, WS; Long, NC; Lowenstein, CJ; Patterson, C; Perrella, MA; Shieh, S; Shore, S; Tsai, JC, 1996) |
| "The hypotension of septic shock is due to systemic vasodilation." | ( Ashton, RC; D'Alessandro, D; Gallant, EM; Landry, DW; Levin, HR; Oliver, JA; Oz, MC; Seo, S, 1997) |
| "Septic shock is a physiological derangement of the cardiovascular system characterized by pathological vasodilation." | ( Kilbourn, RG; Szabó, C; Traber, DL, 1997) |
| "Septic shock is a major cause of death in the world." | ( Klimpel, GR; Niesel, DW; Peterson, JW; Zhang, H, 1997) |
| "Septic shock is a life-threatening disorder caused by lipopolysaccharide (LPS) and other bacterial products." | ( Kurihara, H; Kurihara, Y; Morita, H; Shindo, T; Yazaki, Y, 1998) |
| "Sepsis and septic shock are common problems in the ICU and carry a very high mortality." | ( Parker, MM, 1998) |
| "Its application in septic shock is hazardous." | ( Függer, R; Götzinger, P; Jakesz, R; Losert, U; Riegler, M; Roth, E; Sautner, T; Sedivy, R; Wessely, C, 1998) |
| "Septic shock is a major cause of death among patients in intensive care units." | ( Hon, WM; Khoo, HE; Moochhala, S, 1998) |
| "Septic shock is characterised by infection causing a systemic inflammatory response, end-organ failure and acute circulatory collapse." | ( Matthews, PC; Willatts, SM, 1998) |
| "Septic shock is a major cause of death following trauma and is a persistent problem in surgical patients throughout the world." | ( Titheradge, MA, 1999) |
| "Septic shock is a leading cause of mortality in intensive care units." | ( Arend, WP; Armstrong, RC; Fritz, LC; Gabay, C; Grobmyer, SR; Melchior, M; Nathan, CF; Nicholson, SC; Potter, SH, 1999) |
| "Septic shock is a complex pathophysiologic state characterized by circulatory insufficiency, multiple system organ dysfunction, and frequent mortality." | ( Arteaga, G; Becker, L; Bryant, D; Giroir, BP; Horton, J; Kliewer, A; Maass, D; Thompson, M; White, DJ, 2000) |
| "Septic shock is characterized by a decrease in systemic vascular resistance." | ( Chen, A; Chen, SJ; Chou, TC; Liao, MH; Wu, CC; Yen, MH, 2000) |
| "A major feature of septic shock is the development of a vascular crisis characterized by nonresponsiveness to sympathetic vasoconstrictor agents and the subsequent irreversible fall in blood pressure." | ( Macarthur, H; Misko, TP; Riley, DP; Salvemini, D; Westfall, TC, 2000) |
| "Sepsis and septic shock are a common cause of mortality in critically ill patients." | ( Ayem, ML; Guieu, R; Leone, M; Martin, C; Viviand, X, 2000) |
| "Septic shock is characterized by decreased responsiveness to catecholamines." | ( Annane, D; Bellissant, E, 2000) |
| "Five children with septic shock are presented who had persisting base deficit after large volume resuscitation with 0." | ( Durward, A; Mayer, A; Murdoch, IA; Skellett, S; Tibby, SM, 2000) |
| "Septic shock is one of the leading causes of death in intensive care units world-wide." | ( Annane, D, 2001) |
| "Septic shock is associated with vasopressin deficiency and a hypersensitivity to its exogenous administration." | ( Chittock, DR; Patel, BM; Russell, JA; Walley, KR, 2002) |
| "Septic shock is characterized by arteriolar vasodilation and hypotension." | ( Antunes-Rodrigues, J; Carnio, EC; De Castro, M; Giusti-Paiva, A, 2002) |
| "Both causes of septic shock are associated with an extremely high severity of illness (Acute Physiology and Chronic Health Evaluation II: candidemic septic shock, 32 +/- 10; bacteremic septic shock, 30 +/- 8; p =." | ( Hadley, S; Lee, WW; Nasraway, SA; Ruthazer, R, 2002) |
| "Candidemia with septic shock is infrequent in nonimmunocompromised patients but has a very high mortality rate, a high likelihood of associated multiple organ failure, and possibly a delayed recovery from multiple organ failure." | ( Hadley, S; Lee, WW; Nasraway, SA; Ruthazer, R, 2002) |
| "Septic shock is a serious problem in critically ill and surgical patients throughout the world." | ( Cadenas, AM; Cadenas, S, 2002) |
| "Sepsis and septic shock are very complex and dynamic clinical syndromes." | ( Knöbl, P, 2002) |
| "Severe sepsis and septic shock are relatively common problems in intensive care." | ( Parviainen, I; Ruokonen, E; Uusaro, A, 2002) |
| "Septic shock is still the major cause of death in surgical intensive care unit." | ( Cherng, CH; Chiang, CY; Ho, ST; Wang, HJ; Wong, CS; Wu, CT; Yeh, CC, 2003) |
| "Severe sepsis and septic shock are common causes of morbidity and mortality in critically ill patients." | ( Balk, RA; Gurka, DP; Patel, GP, 2003) |
| "Although septic shock is a highly complex pathophysiological state, the course of septic shock has different phases with different characteristics which need different (special) treatment strategy." | ( Guc, O; Iskit, AB, 2003) |
| "LPS-induced septic shock is characterized by hypotension and vascular hyporeactivity to contracting agents." | ( Autore, G; Cuzzocrea, S; d'Emmanuele di Villa Bianca, R; Di Paola, R; Marzocco, S; Pinto, A; Sorrentino, R, 2004) |
| "Severe sepsis and septic shock are among the most common causes of death in noncoronary intensive care units." | ( Balk, RA, 2004) |
| "Septic shock is more severe when of early onset, as reflected by more severe organ dysfunction, greater lactic acidosis, and higher vasopressor requirements, yet the outcome is better, as reflected by a shorter duration of the shock episode, shorter ICU stay, and slightly lower mortality rates." | ( De Backer, D; Melot, C; Orellana-Jimenez, CE; Roman-Marchant, O; Vincent, JL, 2004) |
| "Septic shock is believed to be a consequence of excessive stimulation of the immune system by bacterial toxins that results in systemic overproduction of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), IL-1, and IL-6." | ( Greeneltch, KM; Haudenschild, CC; Keegan, AD; Shi, Y, 2004) |
| "Sepsis and septic shock are increasing in incidence and mortality." | ( Carrillo-Jimenez, R; Castillo, JR; Hennekens, CH; Zagler, A, 2004) |
| "Septic shock is characterized by hypotension and decreased systemic vascular resistance and impaired vascular reactivity." | ( Arendshorst, WJ; Boffa, JJ, 2005) |
| "Septic shock is the reason of human body organs dysfunctions including the hormonal system." | ( Borkowski, J; Czaban, SL; Jedynak, M; Siemiatkowski, A; Wołczyński, S, 2005) |
| "Melioidosis with septic shock is less common than localized melioidosis in pediatric patients, but is associated with very high mortality." | ( How, HS; Ng, KH; Shah, A; Tee, HP; Yeo, HB, 2005) |
| "Septic shock is a condition that affects many organs, but little is known about the effects on the central nervous system." | ( Eriksson, MB; Hansson, LO; Larsson, A; Lipcsey, M; Sjölin, J, 2005) |
| "Septic shock is caused by Gram-negative bacterial infection." | ( Ding, JL; Ho, B; Li, P; Sun, M; Wohland, T, 2006) |
| ""Septic shock" is defined by hypotension refractory to fluid resuscitation, associated with organ dysfunctions or hypoperfusion." | ( Lebuffe, G; Vallet, B; Wiel, E, 2006) |
| "Septic shock is an important cause of death in pediatric intensive care units." | ( Kabra, SK; Lodha, R; Sarthi, M; Vivekanandhan, S, 2006) |
| "Severe sepsis and septic shock are as common and lethal as other acute life-threatening conditions that emergency physicians routinely confront such as acute myocardial infarction, stroke, and trauma." | ( Abraham, E; Abrahamian, FM; Huang, DT; Moran, GJ; Nguyen, HB; Osborn, T; Rivers, EP; Stevens, D; Talan, DA; Trzeciak, S, 2006) |
| "Septic shock is a major cause of death following trauma and a persistent problem in surgical patients." | ( Antunes-Rodrigues, J; Carnio, EC; Giusti-Paiva, A; Moreto, V, 2006) |
| "Septic shock is a systemic response to severe bacterial infections, generally caused by Gram-negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi-organ failure." | ( Abad, C; Arranz, A; García-Gómez, M; Gomariz, RP; Juarranz, Y; Leceta, J; Martínez, C; Rosignoli, F, 2006) |
| "Septic shock is the leading cause of death in noncoronary intensive care units and the 10th leading cause of death overall." | ( Brouckaert, P; Bultinck, J; Cauwels, A; Sips, P; Vakaet, L, 2006) |
| "The septic shock is characterized by decrease in median arterial pressure; many researchers have been related a deficiency in vasopressin release during the septic shock." | ( Antunes-Rodrigues, J; Carnio, EC; Moreto, V; Stabile, AM, 2006) |
| "Septic shock is characterised by vasodilation, myocardial depression and impaired microcirculatory blood flow, resulting in redistribution of regional blood flow." | ( Pickkers, P; Sleigh, JW; Van der Hoeven, JG; van Haren, FM, 2007) |
| "Hypodynamic septic shock is associated with a poor prognosis." | ( Booke, M; Ertmer, C; Hucklenbruch, C; Lange, M; Morelli, A; Rehberg, S; Van Aken, H; Westphal, M, 2007) |
| "Sepsis and septic shock are very common conditions among critically ill patients that lead to multiple organ dysfunction syndrome (MODS) and death." | ( Benseñor, FE; Cicarelli, DD; Vieira, JE, 2007) |
| "Septic shock is a common severe syndrome leading to endothelium damage and multiple organ failure, with increased data suggesting the principle role of oxidative stress." | ( Forceville, X, 2007) |
| "Patients with septic shock are haemodynamically unstable and suffer from vasodilation." | ( Jalowy, A; Kienbaum, P; Lehmann, N; Peters, J; Prante, C; Sander, A, 2008) |
| "Septic shock is still the leading cause of death in patients with vasculitis." | ( Tervaert, JW, 2007) |
| "Septic shock is a complex syndrome that claims over 200,000 lives per year in the United States." | ( Ichinose, F, 2008) |
| "Septic shock is an adverse clinical condition resulting in multiple organ failure from global tissue hypoxia." | ( Goto, K; Hidaka, S; Kusaka, J; Noguchi, T; Oyama, Y; Shingu, C; Yamamoto, S, 2008) |
| "Vasodilatory septic shock is characterized by profound vasodilation of the peripheral circulation, relative refractoriness to catecholamines and a relative deficiency of the posterior pituitary hormone, vasopressin." | ( Holmes, CL; Walley, KR, 2008) |
| "Sepsis and septic shock are major causes of morbidity and mortality in critically ill patients." | ( Assreuy, J; Fernandes, D, 2008) |
| "Patients with septic shock are under considerable oxidative stress, and 2-AG plays an important role in the cardiovascular status of these patients." | ( Iwai, K; Kase, Y; Obata, T; Okamoto, Y; Saito, K; Takinami, M; Tanifuji, Y; Yokoyama, K, 2008) |
| "The incidence of septic shock is increasing and mortality ranges from 30% to 70%." | ( Russel, JA, 2008) |
| "Severe sepsis and septic shock are among the most important causes of morbidity and mortality in patients admitted to the intensive care unit." | ( Hollenberg, SM; Zanotti-Cavazzoni, SL, 2009) |
| "Septic shock is associated with vasopressin deficiency and hypersensitivity to its exogenous administration." | ( Hoshino, J; Katori, H; Masuoka, K; Sawa, N; Suwabe, T; Takaichi, K; Takemoto, F; Taniguchi, S; Ubara, Y; Uchida, N; Wake, A, 2009) |
| "Severe sepsis and septic shock are defined according to the criteria of the consensus conference of the ACCP/SCCM excluding the leukocyte count since all the patients were neutropenic." | ( Abid, HB; Achour, M; Aissaoui, L; Amor, RB; BelHadjAli, Z; Bouterâa, W; Jeddi, R; Kacem, K; Lakhal, RB; Meddeb, B; Turki, A, 2010) |
| "Septic shock is associated with life-threatening vasodilation and hypotension." | ( Brouckaert, P; Cauwels, A; Janssen, B; Rogge, E, 2010) |
| "Septic shock is characterized by vasodilation and hypotension despite increased vasoconstrictors." | ( Giusti-Paiva, A; Santiago, MB, 2010) |
| "Sepsis and septic shock are the dominant causes of acute kidney injury, accounting for nearly 50 % of episodes of acute renal failure." | ( Chvojka, J; Karvunidis, T; Kroužecký, A; Matějovič, M; Novák, I; Raděj, J; Sýkora, R, 2010) |
| "Neonatal septic shock is a devastating condition associated with high morbidity and mortality." | ( Wong, HR; Wynn, JL, 2010) |
| "Septic shock is a major cause of morbidity and mortality in the intensive care unit, and effective therapies are limited." | ( Flynn, JD; Hatton, KW; McMahon Horner, D; Paciullo, CA, 2010) |
| "Septic shock is a major health care problem that affects a heterogeneous population of patients." | ( Bohé, J; Guignant, C; Lepape, A; Malcus, C; Monneret, G; Poitevin, F; Venet, F; Voirin, N, 2010) |
| "Death from septic shock is caused by refractory hypotension and multiple organ failure (MOF)." | ( Brouckaert, P; Cauwels, A, 2011) |
| "Severe sepsis and septic shock are common complications in the intensive care unit and associated with high mortality." | ( Drexel, H; Fraunberger, P; Walli, AK, 2010) |
| "Septic shock is the progression of those physiologic changes to the extent that delivery of oxygen and metabolic substrate to tissues is compromised." | ( Standage, SW; Wong, HR, 2011) |
| "Septic shock is the leading causes of death in intensive care units." | ( Inal, MT; Memiş, D; Sut, N, 2012) |
| "Septic shock is characterized by altered tissue perfusion associated with persistent arterial hypotension." | ( Creteur, J; De Backer, D; Donadello, K; Favory, R; Salgado, DR; Taccone, FS; Thooft, A; Vincent, JL, 2011) |
| "The hemodynamics of septic shock is characterized by a primary reduction of vascular tone, which defines vasoplegia." | ( Jeanneret, S; Liaudet, L; Sanchez, B, 2011) |
| "The presence of septic shock is a strong predictor of mortality." | ( Chakrapani, M; Damodar, S; Lipika, S; Vidyalakshmi, K; Vishal, S, 2012) |
| "Septic shock is a serious condition with a consequent drop in blood pressure and inadequate tissue perfusion." | ( Elias, LL; Giusti-Paiva, A; Rodrigues, JA; Santiago, MB; Vieira, AA, 2013) |
| "Sepsis and septic shock are common cause of hospitalisation in intensive care unit." | ( Duricová, J; Grundmann, M; Kacířová, I; Martínek, A; Petejová, N; Plášek, J; Valkovský, I; Zahálková, J, 2012) |
| "Septic shock is a systemic inflammatory response syndrome, and it is the leading cause of death in intensive care units." | ( Beduschi, MG; Buss, ZS; Dalmarco, EM; Guimarães, CL, 2013) |
| "As sepsis and septic shock are dominant causes of acute kidney injury (AKI), we investigated whether PCT is an early predictor of AKI in patients with symptoms of infection." | ( Dai, Z; Gao, B; He, Y; Huang, X; Li, G; Luo, T; Miao, Q; Nie, X; Song, H; Wang, L; Wu, B, 2013) |
| "Septic shock is a serious condition leading to high mortality and morbidity." | ( Noppakaorattanamanee, K; Permpikul, C; Poompichet, A; Ratanarat, R; Tongyoo, S, 2013) |
| "Septic shock is the leading cause of death in intensive care units worldwide, resulting from a progressive systemic inflammatory reaction causing cardiovascular and organ failure." | ( Brouckaert, P; Bultinck, J; Cauwels, A; Descamps, B; Rogge, E; Sips, M; Van Nieuwenhuysen, T; Vandendriessche, B; Vanhove, C, 2013) |
| "Sepsis and septic shock are associated with high mortality rates and the majority of sepsis patients die due to complications of multiple organ failure (MOF)." | ( Brouckaert, P; Cauwels, A; Goossens, V; Rogge, E; Stasch, JP; Vandenabeele, P; Vandendriessche, B, 2013) |
| "Septic shock is still related to unacceptably high morbidity and mortality." | ( Huang, Y; Qiu, H; Qiu, X; Xu, J; Yang, Y, 2014) |
| "Severe sepsis and septic shock are associated with high mortality." | ( Permpikul, C; Sringam, P; Tongyoo, S, 2014) |
| "Mortality from septic shock is highly heritable." | ( Boyd, JH; Nakada, TA; Russell, JA; Thair, SA; Walley, KR, 2015) |
| "Septic shock is associated with generally not only higher levels but also greater variance of maximal cortisol secretion rate when compared with control and sepsis groups." | ( Dorin, RI; Qualls, CR; Schrader, RM; Torpy, DJ; Urban, FK, 2015) |
| "Severe sepsis or septic shock is one of the rising causes for mortality worldwide representing nearly 10% of intensive care unit admissions." | ( Balaji, KN; Biswas, A; Guru Row, TN; Prasad, KD; Sekar, K; Trinath, J, 2014) |
| "Septic shock is a major healthcare problem effecting people worldwide with high mortality rate." | ( Apibunyopas, Y, 2014) |
| "Severe sepsis and septic shock are among the leading causes of mortality in the intensive care unit." | ( Bearman, GM; Gupta, RG; Hartigan, SM; Kashiouris, MG; Sessler, CN, 2015) |
| "Sepsis and septic shock are commonly present in the ICU and accompanied by significant morbidity, mortality, and cost." | ( Bornstein, S; Dröse, S; Heerdegen, L; Jennewein, C; Kanczkowski, W; Kantharajah, A; Scheller, B; Tran, N; Zacharowski, K, 2016) |
| "Septic shock is characterised by refractory hypotension and is typically managed by fluid resuscitation and administration of catecholamine vasopressors such as norepinephrine." | ( Carr, AC; Fowler, AA; Natarajan, R; Shaw, GM, 2015) |
| "Patients with septic shock are heterogeneous, making it particularly difficult to provide therapeutic recommendations that are safe and effective for all." | ( Vincent, JL, 2016) |
| "Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection." | ( Annane, D; Bellomo, R; Bertolini, G; Brunkhorst, FM; Deutschman, CS; Shankar-Hari, M; Singer, M, 2015) |
| "Sepsis and septic shock are the common complications in ICUs." | ( Chen, X; Lan, D; Li, T; Liu, L; Wu, H; Wu, Y; Yang, G; Zang, J; Zhu, Y, 2016) |
| "Septic shock is a major cause of death worldwide and a considerable healthcare burden in the twenty-first century." | ( Angus, DC; Kox, M; Pickkers, P; Stolk, RF; van der Hoeven, JG; van der Poll, T, 2016) |
| "Septic shock is a major healthcare problem." | ( El-Nawawy, A; Khater, D; Omar, H; Wali, Y, 2017) |
| "Refractory septic shock is defined as persistently low mean arterial blood pressure despite volume resuscitation and titrated vasopressors/inotropes in patients with a proven or suspected infection and concomitant organ dysfunction." | ( Agosta, S; Annoni, F; Antonucci, E; Gleeson, PJ; Orlando, S; Scolletta, S; Taccone, FS; Velissaris, D, 2017) |
| "Septic shock is a leading cause of mortality in intensive care units throughout the world." | ( DeGrado, JR; Schurr, JW; Szumita, PM, 2017) |
| "Septic shock is associated with high mortality." | ( Åstrand, P; Barle, H; Eksborg, S; Frostell, C; Hallengren, M, 2017) |
| "Septic shock is a life-threatening condition that occurs when the blood pressure drops to a low level after an infection." | ( Arita, Y; Hasegawa, S; Segawa, T; Yamamoto, S, 2017) |
| "Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities." | ( Ali Benali, M; Amathieu, R; Annane, D; Asehnoune, K; Baudin, F; Bellissant, E; Bohé, J; Boulain, T; Brun-Buisson, C; Capellier, G; Cariou, A; Charpentier, C; Chimot, L; Colin, G; Combes, A; Constantin, JM; Cook, F; Dargent, A; Dhonneur, G; Forceville, X; François, B; Hissem, T; Leroy, O; Loriferne, JF; Martin, C; Maxime, V; Megarbane, B; Mercier, E; Misset, B; Petitpas, F; Quenot, JP; Renault, A; Schwebel, C; Siami, S; Slama, M; Souweine, B; Timsit, JF, 2018) |
| "A key player in septic shock is Tumor Necrosis Factor-alpha (TNF-α)." | ( Elvers, M; Jurk, K; Kaup, SC; Klier, M; Krüger, I; Lang, PA; Reusswig, F; Spelleken, M; Urbahn, MA, 2018) |
| "Septic shock is a life-threatening clinical situation associated with acute myocardial and vascular dysfunction, whose pathophysiology is still poorly understood." | ( Baganha, F; Carneiro, F; Castro-Chaves, P; Cerqueira, RJ; Gonçalves, F; Heymans, S; Laundos, TL; Leite-Moreira, AF; Mendonça, L; Nascimento, DS; Paiva, JA; Pinto-do-Ó, P; Quina-Rodrigues, C; Reguenga, C; Ribeiro, S; Roncon-Albuquerque, R; Schroen, B; Soares-Dos-Reis, R; Vasques-Nóvoa, F; Verhesen, W, 2018) |
| "Septic shock is a life-threatening disorder associated with high mortality rates requiring rapid identification and intervention." | ( Bauer, SR; Lat, I; Sacha, GL, 2019) |
| "Urosepsis and septic shock are a critical situation leading to a mortality rate up to 30% in patients with obstructive diseases of the urinary tract." | ( Gong, S; Hu, X; Jiang, Y; Li, J; Shang, X; Yu, R; Zhang, X; Zhang, Y, 2019) |
| "Septic shock is a life threatening condition and a medical emergency." | ( Jadhav, AP; Sadaka, FG, 2019) |
| "Septic shock is a serious stage of sepsis with a hospital mortality rate of more than 40%." | ( Chen, Q; Liu, L; Zheng, R, 2019) |
| "Septic shock is associated with poor outcomes." | ( Bailey, M; Bellomo, R; Deane, AM; Eastwood, GM; Frei, D; French, C; Fujii, T; Luethi, N; Orford, N; Shehabi, Y; Udy, AA; Young, PJ, 2019) |
| "Sepsis and septic shock are significant health issues in the United States." | ( Grace, Y; Guirguis, E; Maarsingh, H; Tkachuk, E; Tran, TC, 2020) |
| "Septic shock is a life-threatening condition with underlying circulatory and cellular/metabolic abnormalities." | ( Choi, SH; Chung, SP; Hwang, SY; Jo, IJ; Jo, YH; Kim, D; Kim, S; Kim, T; Kim, WY; Kim, YJ; Kong, T; Lee, HJ; Park, JE; Ryoo, SM; Shin, J; Shin, TG; Suh, GJ; You, KM, 2019) |
| "Septic shock is characterized by severe metabolic and hemodynamic alterations." | ( Brandenburger, T; Dimski, T; Kindgen-Milles, D; Slowinski, T, 2020) |
| "Sepsis and septic shock are medical emergencies resulting in significant morbidity and mortality." | ( Gillion, AR; Mitchell, AB; Muthiah, MP; Ryan, TE; Wells, LD, 2020) |
| "Sepsis and septic shock are major causes of morbidity and mortality worldwide, associated with a high economic and social burden on healthcare systems and communities, yet with few definite treatment modalities." | ( Al Kurdi, MH; Aletreby, WT; Alharthy, AM; Alodat, MA; Alzayer, W; Farrag, HA; Hamido, HM; Huwait, BM; Karakitsos, D; Madi, AF; Mahmood, NN; Mumtaz, SA; Ramadan, OE; Soliman, IR, 2019) |
| "Septic shock is a systemic inflammation associated with cell metabolism disorders and cardiovascular dysfunction." | ( Aillerie, V; Bigot, E; Cadiet, J; Chatham, JC; Denis, M; Erraud, A; Ferron, M; Gauthier, C; Lauzier, B; Mevel, M; Persello, A; Prat, V; Rozec, B, 2019) |
| "Septic shock is a common and highly morbid condition." | ( Andersen, LW; Donnino, MW; Grossestreuer, AV; Huang, DT; Moskowitz, A; Yankama, T, 2019) |
| "Septic shock is associated with massive release of endogenous catecholamines." | ( Beilstein, C; Boerma, C; Calcinaro, S; Chiche, JD; D'Egidio, A; Damiani, E; Domizi, R; Donati, A; Harris, S; Koetsier, PM; Madden, MP; McAuley, DF; Morelli, A; Pelaia, P; Royer, P; Shankar-Hari, M; Singer, M; Wickboldt, N; Zolfaghari, P, 2020) |
| "Septic shock is the main cause of morbidity and mortality in patients and second leading cause of mortality among subjects in noncoronary intensive care units." | ( Khodashahi, R; Sarjamee, S, 2020) |
| "Sepsis and septic shock are characterized by a release of cytokines into the circulation." | ( Brandenburger, T; Dimski, T; Kindgen-Milles, D; MacKenzie, C, 2020) |
| "Septic shock is associated with a strong inflammatory response that induces vasodilation and vascular hyporeactivity." | ( Bédos, JP; Bruneel, F; Henry-Lagarrigue, M; Legriel, S; Soppelsa, F; Spreux-Varoquaux, O; Troché, G; Yehia, A, 2020) |
| "Septic shock is associated with decreased vasopressor responsiveness." | ( Bailey, M; Bellomo, R; Cioccari, L; Eastwood, GM; Howe, B; Jakob, SM; Luethi, N; Merz, TM; Messmer, AS; Peck, L; Proimos, HK; Shehabi, Y; Takala, J; Young, H, 2020) |
| "Septic shock is a life-threatening manifestation of infection with a mortality of 20-50% [1]." | ( Brown, SM; Harley, JB; Sorensen, J; Tang, Y, 2021) |
| "Septic shock is a leading cause of death and morbidity worldwide." | ( Day, J; Donovan, K; McKechnie, SR; Shah, A, 2021) |
| "Septic shock is characterized by breakdown of the endothelial glycocalyx and endothelial damage, contributing to fluid extravasation, organ failure and death." | ( Bellani, G; Caironi, P; Coppolecchia, S; Ferlicca, D; Fracasso, C; Gattinoni, L; Gobbi, M; Grasselli, G; Latini, R; Marino, A; Masson, S; Meessen, JMTA; Novelli, D; Pesenti, A; Piotti, A; Salati, G; Savioli, M, 2021) |
| "Sepsis and septic shock are severe medical conditions that can damage multiple organs with a higher risk of mortality." | ( Lee, YR; Varughese, JT; Vo, K, 2022) |
| "Septic shock is characterized by dysregulated vascular permeability." | ( Higashijima, U; Izumikawa, K; Kakiuchi, S; Mori, M; Morimoto, K; Sekino, M; Takaki, M; Tanaka, T; Tasaki, O; Tashiro, M; Yamashita, Y, 2021) |
| "Septic shock is characterized by an uncontrolled inflammatory response and microcirculatory dysfunction." | ( Chen, L; Gao, Y; Hong, Y; Hu, C; Huang, Z; Liu, D; Ren, B; Tian, X; Wang, X; Yin, R; Yu, Y; Zhang, C; Zhang, Z; Zhou, J; Zhu, C, 2021) |
| "Septic shock is associated with increased mortality because of an inadequacy to maintain mean arterial blood pressure (MAP) despite volume resuscitation and the use of vasopressors." | ( Balakumar, P; Jagadeesh, G; Senatore, F, 2021) |
| "Septic shock is a lethal disease responsible for a large proportion of deaths in the Intensive Care Unit (ICU), even with therapy centered on fluid resuscitation, use of vasopressors and empirical antibiotic therapy applied within the first hour of diagnosis." | ( Auxiliadora-Martins, M; Basile-Filho, A; Becari, C; Evora, PRB; Luis-Silva, F; Martins-Filho, OA; Menegueti, MG; Peres, LM; Petroski-Moraes, BC; Sato, L; Sepeda, CDR, 2022) |
| "Septic shock is often characterized by tachycardia and a hyperdynamic hemodynamic profile." | ( Balaji, L; Berg, K; Chase, M; Cocchi, MN; Dargin, J; Donnino, MW; Grossestreuer, A; Liu, X; Moskowitz, A; Patel, PV, 2022) |
| "Septic shock is an acute pathophysiological condition characterized by vasodilation, hypotension, decreased circulating blood volume, tissue hypoxia, organ failure, and high lethality." | ( Machavariani, K; Pachkoria, E; Ratiani, L; Rurua, M; Sanikidze, T; Shoshiashvili, V, 2022) |
| "Septic shock is characterized by hypotension requiring vasopressors after adequate fluid resuscitation with elevated lactate." | ( Dellinger, RP; Patel, S; Puri, N, 2022) |
| "Septic shock is a serious clinical syndrome leading to high mortality." | ( Chen, H; Du, Y; Huang, S; Jia, Z; Long, G; Pei, Z; Wang, Q; Wei, K; Wu, M; Xia, W; Zhang, Y, 2023) |
| "Sepsis and septic shock are severe and difficult-to-treat conditions with high lethality." | ( Guedes, GV; Minicucci, MF; Tanni, SE, 2022) |
| "Sepsis and septic shock are the most common causes of death in non-cardiac surgical intensive care units (ICU)." | ( Bucher, M; Burgdorff, AM; Christel, A; Dinse, CM; Flöther, L, 2022) |
| "Sepsis and septic shock are the most common causes of death in non-cardiac surgical intensive care units (ICU)." | ( Bucher, M; Burgdorff, AM; Christel, A; Dinse, CM; Flöther, L, 2022) |
| "Sepsis and septic shock are the most common causes of death in non-cardiac surgical intensive care units (ICU)." | ( Bucher, M; Burgdorff, AM; Christel, A; Dinse, CM; Flöther, L, 2022) |
| "Sepsis and septic shock are the main causes of mortality and complications in intensive care units all over the world." | ( Abbasalizad Farhangi, M; Askari, G; Karimi, A; Karimi, M; Vajdi, M, 2023) |
| "Septic shock is a leading cause of death in intensive care units (ICUs), with short-term mortality rates of 35-40%." | ( Gu, WJ; He, D; Hu, H; Li, C; Lu, X; Lyu, J; Qiu, M; Yin, H; Zhang, L, 2023) |
| "Septic shock is even rarer, with high mortality despite therapy." | ( Ausman, C; Edmondson, J; Ewers, EC; Maves, RC; McCool, I; Perry, A; Walsh, JC; Wisniewski, P, 2023) |
| "Sepsis and septic shock are disorders of tissue perfusion and microcirculation associated with increased mortality." | ( Turan, YB, 2023) |
| "Septic shock is one of the leading causes of mortality in intensive care units." | ( Fu, Q; Fu, S; Liang, TB; Xu, Z; Yu, W; Zhang, S, 2023) |
| "Septic shock is a global public health burden." | ( Chen, Y; Gao, S; Guo, Y; He, H; Hu, Y; Liu, D; Ma, X; Shan, G; Su, L; Wang, L; Zhou, X, 2023) |
| "Septic shock is the development of sepsis to refractory circulatory collapse and metabolic derangements, characterized by persistent hypotension and increased lactate levels." | ( Chen, MZ; Deng, X; Dong, X; Guo, SB; Li, AJ; Lin, JH; Lin, ZF; Lin, ZH; Liu, JX; Mei, X; Shi, B; Tian, YP; Yuan, DS; Yuan, SY; Zha, JJ; Zhang, F; Zhang, L; Zhou, P, 2023) |