Page last updated: 2024-09-27

Amyloid Neuropathies

Disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. Familial, primary (nonfamilial), and secondary forms have been described. Some familial subtypes demonstrate an autosomal dominant pattern of inheritance. Clinical manifestations include sensory loss, mild weakness, autonomic dysfunction, and CARPAL TUNNEL SYNDROME. (Adams et al., Principles of Neurology, 6th ed, p1349)

Synonyms(4)

Synonym
Amyloid Neuropathies
Neuropathies, Amyloid
Amyloid Neuropathy, Secondary
Amyloid Polyneuropathies

Research Excerpts

Overview

ExcerptReference
"Hereditary amyloid polyneuropathies are rare, heterogeneous group of autosomal dominant disorders and deserve special attention because of its rare presentation, multisystem involvement and significant therapeutic implications if diagnosed early."( Bagarhatta, R; Handa, R; Jain, A; Jain, R; Jain, RS; Mathur, T; Raghavendra, BS, 2014)

Research

Studies (148)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's80 (54.05)12.5806
2000's39 (26.35)18.1394
2010's26 (17.57)28.8240
2020's3 (2.03)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetaldehyde0low10
ammonium hydroxide0low10
dibenzofuran0low10
cytosine0low10
glycine0low40
histamine0low10
hydrogen0low10
iodine0low10
pteridines0low10
sulfites0medium21
thymine0low10
trimethylamine0low10
urea0medium31
1-anilino-8-naphthalenesulfonate0low20
diclofenac0low20
diflunisal0low40
flufenamic acid0low20
flurbiprofen0low10
guanidine0low10
propranolol0low10
succinylcholine0low10
thalidomide0low10
thyroxine0low30
prednisone0low10
alanine0low90
serine0low90
glutamine0low20
lysine0low20
phenylephrine0low10
tyrosine0low40
leucine0low40
methacholine chloride0low10
methionine0low150
colchicine0medium51
asparagine0low10
histidine0low20
valine0low110
threonine0low30
tryptophan0low10
isoleucine0low50
acrylamide0low10
catechin0low30
benzoxazoles0medium62
thiazoles0low20
citrulline0low10
congo red0low60
acetylcysteine0low10
d-alpha tocopherol0low10
thioflavin t0low10
gadolinium0low20
tetradecanoylphorbol acetate0low10
4-methoxyamphetamine0low10
glutamic acid0low20
substance p0low10
dobutamine0low10
fomesafen0low10
3-iodobenzylguanidine0medium61
epigallocatechin gallate0low30
phenoxazine0low10
fluorodeoxyglucose f180low10
2-methoxyacetaldehyde0low10
droxidopa0low30
iodofiltic acid0low10
proline0low50
biotin0low10
benzofurans0low10
inositol 3-phosphate0low10
resveratrol0low10
tacrolimus0low10
melphalan0low30
stilbenes0low10
succimer0low10
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole0low20
rhyncophylline0low10
cystine0low10
bilirubin0low10
4-hydroxy-2-nonenal0low10
thallium0medium11
cysteine0low40
pregabalin0low10
technetium tc 99m pyrophosphate0low10
dolastatin 100medium11
g(m1) ganglioside0low10
alpha-synuclein0low30
tafamidis0medium62
losartan potassium0medium21
cholecystokinin0low10
amyloid beta-protein (17-42)0low10
gastrins0low10
beta-endorphin0low20
oligonucleotides0low30
technetium tc 99m sestamibi0low10
florbetapir f 180low20
vasoactive intestinal peptide0low10
heparitin sulfate0low10
ascorbic acid0low10
minocycline0low10
oxyntomodulin0low10
cyclosporine0low10
muramidase0low40
amyloid beta-peptides0low20
technetium tc 99m dimercaptosuccinic acid0low10
sildenafil citrate0low10
molybdenum cofactor0low10
eye0low20
metallothionein0low10

Protein Targets (906)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase1001
thioredoxin reductase160016
USP1 protein, partial9009
TDP1 protein170017
vitamin D3 receptor isoform VDRA6006
importin subunit beta-1 isoform 13003
flap endonuclease 17007
serine/threonine-protein kinase PLK12002
snurportin-13003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
GTP-binding nuclear protein Ran isoform 12002
DNA polymerase eta isoform 13003
DNA polymerase iota isoform a (long)7007
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
geminin120012
DNA polymerase kappa isoform 19009
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0202
Transthyretin04817
Fatty acid-binding protein, intestinal0415
Fatty acid-binding protein, adipocyte0112
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0202
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G3003
Fatty acid-binding protein 50011
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140202
Amyloid-beta precursor protein0819
dopamine D1 receptor4004
GLS protein110011
Thrombopoietin3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)8008
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C19 precursor2002
ras-related protein Rab-9A4004
histone acetyltransferase KAT2A isoform 13003
lethal factor (plasmid)7007
POU domain, class 2, transcription factor 10003
Spike glycoprotein6006
ATP-dependent phosphofructokinase7007
Microtubule-associated protein tau100010
Transient receptor potential cation channel subfamily A member 10112
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0113
5-hydroxytryptamine receptor 1A0428
5-hydroxytryptamine receptor 1B0314
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0415
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
acetylcholinesterase7007
hypoxia-inducible factor 1 alpha subunit7007
RAR-related orphan receptor gamma160016
SMAD family member 24004
SMAD family member 34004
GLI family zinc finger 3180018
AR protein220022
caspase 7, apoptosis-related cysteine protease6006
thyroid stimulating hormone receptor8008
estrogen receptor 2 (ER beta)100010
nuclear receptor subfamily 1, group I, member 3130013
progesterone receptor8008
glucocorticoid receptor [Homo sapiens]120012
retinoic acid nuclear receptor alpha variant 1180018
retinoid X nuclear receptor alpha120012
estrogen-related nuclear receptor alpha200020
farnesoid X nuclear receptor9009
pregnane X nuclear receptor130013
estrogen nuclear receptor alpha290029
peroxisome proliferator-activated receptor delta8008
peroxisome proliferator activated receptor gamma150015
vitamin D (1,25- dihydroxyvitamin D3) receptor130013
caspase-36006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a120012
thyroid stimulating hormone receptor6006
activating transcription factor 69009
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
v-jun sarcoma virus 17 oncogene homolog (avian)100010
Histone H2A.x8008
Caspase-72002
caspase-32002
thyroid hormone receptor beta isoform 2140014
heat shock protein beta-14004
nuclear factor erythroid 2-related factor 2 isoform 1160016
Voltage-dependent calcium channel gamma-2 subunit7007
Cellular tumor antigen p53150015
Glutamate receptor 272110
ATPase family AAA domain-containing protein 55005
Ataxin-28008
Chain A, 2-oxoglutarate Oxygenase8008
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
15-lipoxygenase, partial3003
pregnane X receptor3003
phosphopantetheinyl transferase9009
NFKB1 protein, partial2002
regulator of G-protein signaling 45005
arylsulfatase A7007
euchromatic histone-lysine N-methyltransferase 2170017
Bloom syndrome protein isoform 17007
D(1A) dopamine receptor5005
thyroid hormone receptor beta isoform a7007
peripheral myelin protein 225005
survival motor neuron protein isoform d6006
muscarinic acetylcholine receptor M13003
Histone deacetylase 30101
Solute carrier family 22 member 60101
Histone deacetylase 40101
Histone deacetylase 10101
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
aldehyde dehydrogenase 1 family, member A1100010
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Fibroblast growth factor receptor 40101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Carbonic anhydrase 107017
Carbonic anhydrase 207018
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0003
Glutamate receptor ionotropic, NMDA 1 06212
Proton-coupled amino acid transporter 10607
Adenosine deaminase0001
Carbonic anhydrase 40104
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase6006
cytochrome P450 family 3 subfamily A polypeptide 4110011
IDH14004
chromobox protein homolog 19009
nuclear factor erythroid 2-related factor 2 isoform 24004
lethal(3)malignant brain tumor-like protein 1 isoform I1001
lamin isoform A-delta10130013
Polyphenol oxidase 20203
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Alpha-2B adrenergic receptor0326
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Neutral amino acid transporter A0404
Neutral amino acid transporter B(0)0404
Carbonic anhydrase-like protein, putative0007
Amino acid transporter0404
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, Cruzipain1001
caspase-1 isoform alpha precursor2002
Caspase-71001
Inositol monophosphatase 12002
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10305
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
apical membrane antigen 1, AMA13003
nonstructural protein 10101
green fluorescent protein, partial0101
insulin-degrading enzyme isoform 10011
Streptavidin0011
Receptor-type tyrosine-protein phosphatase beta0001
peripheral myelin protein 22 isoform 14004
DNA polymerase beta3003
neuropeptide S receptor isoform A2002
Prostaglandin G/H synthase 1 0202
Arginase 0202
Pancreatic triacylglycerol lipase0101
Prothrombin0123
Prostaglandin G/H synthase 10628
Aldo-keto reductase family 1 member B10505
Carbonic anhydrase 40409
Prostaglandin G/H synthase 10505
Carbonic anhydrase 60308
Sucrase-isomaltase, intestinal0202
Adenosine receptor A11105
Adenosine receptor A2a0104
Prostaglandin G/H synthase 20505
Mu-type opioid receptor0113
Delta-type opioid receptor0113
Kappa-type opioid receptor0113
Xanthine dehydrogenase/oxidase0101
Melatonin receptor type 1A0011
Melatonin receptor type 1B0011
Death-associated protein kinase 10101
Beta-secretase 10202
Prostaglandin G/H synthase 20404
Carbonic anhydrase 30101
Dihydroorotate dehydrogenase 0101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
General amino-acid permease GAP10001
Nitric oxide synthase, brain0101
Nitric oxide synthase, brain 0101
Chain A, Beta-lactamase4004
Chain A, Ferritin light chain3003
Luciferase120012
interleukin 81001
endonuclease IV1001
PAX80001
ATAD5 protein, partial3003
Fumarate hydratase3003
PPM1D protein3003
Smad33003
polyprotein3003
67.9K protein3003
glucocerebrosidase3003
aryl hydrocarbon receptor9009
nuclear receptor subfamily 1, group I, member 22002
nuclear receptor subfamily 0 group B member 10101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C9 precursor2002
atrial natriuretic peptide receptor 2 precursor2002
steroidogenic factor 10101
cytochrome P450 3A4 isoform 14004
muscleblind-like protein 1 isoform 13003
Gamma-aminobutyric acid receptor subunit pi4116
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40707
Solute carrier family 22 member 30405
Bile salt export pump014014
Interferon beta8008
Tubulin alpha-1A chain0415
Tubulin beta chain0314
Plasma kallikrein0005
Tubulin beta-4A chain0326
ATP-dependent translocase ABCB10101
Tubulin beta chain0326
ATP-dependent translocase ABCB10508
Cytochrome P450 3A40606
Tubulin alpha-3C chain0326
Serine/threonine-protein kinase pim-10101
Gamma-aminobutyric acid receptor subunit beta-14116
Gamma-aminobutyric acid receptor subunit delta4116
Gamma-aminobutyric acid receptor subunit gamma-24116
Gamma-aminobutyric acid receptor subunit alpha-54116
Gamma-aminobutyric acid receptor subunit alpha-34116
ATP-dependent translocase ABCB10101
Gamma-aminobutyric acid receptor subunit gamma-14116
Gamma-aminobutyric acid receptor subunit alpha-24116
Gamma-aminobutyric acid receptor subunit alpha-44116
Gamma-aminobutyric acid receptor subunit gamma-34116
Gamma-aminobutyric acid receptor subunit alpha-64116
Histamine H2 receptor3014
Nuclear receptor ROR-gamma4004
Gamma-aminobutyric acid receptor subunit alpha-14116
Gamma-aminobutyric acid receptor subunit beta-34116
Gamma-aminobutyric acid receptor subunit beta-24116
Tubulin alpha-1B chain0326
Tubulin alpha-4A chain0326
Tubulin beta-4B chain0326
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0326
Tubulin beta-2A chain0326
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0326
Tubulin beta-2B chain0404
Tubulin alpha-3E chain0326
Tubulin alpha-1A chain0326
Similar to alpha-tubulin isoform 1 0303
Similar to alpha-tubulin isoform 1 0303
GABA theta subunit4116
CREB-binding protein1102
Canalicular multispecific organic anion transporter 10606
Tubulin alpha-1C chain0326
Tubulin beta-6 chain0326
Tubulin beta-2B chain0326
Gamma-aminobutyric acid receptor subunit epsilon4116
Tubulin beta-1 chain0326
B2 bradykinin receptor0101
Dihydrofolate reductase0406
Dihydrofolate reductase0101
Chymotrypsinogen A0001
Beta-lactamase0001
Beta-galactosidase0102
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20202
PH domain leucine-rich repeat-containing protein phosphatase 20101
Chymotrypsin-C0101
Deoxycytidine kinase0001
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Cytochrome P450 1A10011
Aryl hydrocarbon receptor0011
Aldo-keto reductase family 1 member B100202
UDP-glucuronosyltransferase 1A90102
Transient receptor potential cation channel subfamily A member 10134
Cytochrome c oxidase subunit 20202
Fatty acid-binding protein, liver0202
Albumin0359
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Cytochrome P450 2C9 0506
Aldo-keto reductase family 1 member B10202
UDP-glucuronosyltransferase 2B70104
UDP-glucuronosyltransferase 1-60202
UDP-glucuronosyltransferase 1A1 0303
UDP-glucuronosyltransferase 1A40102
Sodium- and chloride-dependent GABA transporter 10101
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin G/H synthase 2 0202
UDP-glucuronosyltransferase 1A30002
UDP-glucuronosyltransferase 2B10 0101
Sodium- and chloride-dependent betaine transporter0101
Cytochrome P450 2J20303
Prostaglandin G/H synthase 20202
Carbonic anhydrase 90308
Solute carrier family 22 member 60303
Prostaglandin G/H synthase 1 0303
Multidrug and toxin extrusion protein 10101
P2Y purinoceptor 120101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
electroneutral potassium-chloride cotransporter KCC20011
G5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear receptor ROR-gamma isoform 16006
HLA class I histocompatibility antigen, B alpha chain 5005
High mobility group protein B10011
Disintegrin and metalloproteinase domain-containing protein 171102
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase0202
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
glp-1 receptor, partial7007
GALC protein3003
EWS/FLI fusion protein9009
cytochrome P450 2D65005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)4004
mu-type opioid receptor isoform MOR-10011
huntingtin isoform 22002
5-hydroxytryptamine receptor 2A0011
Solute carrier family 22 member 1 0203
Carbonic anhydrase 120207
Epidermal growth factor receptor0101
Tyrosine-protein kinase Lck0202
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30207
Beta-2 adrenergic receptor0426
Beta-1 adrenergic receptor0426
Polyunsaturated fatty acid lipoxygenase ALOX150101
Sodium-dependent noradrenaline transporter 0628
Alpha-1D adrenergic receptor0214
Carbonic anhydrase 5A, mitochondrial0207
D(3) dopamine receptor0202
Carbonic anhydrase 70207
Sodium-dependent dopamine transporter 0202
Carbonic anhydrase 130204
Sigma non-opioid intracellular receptor 10404
Carbonic anhydrase 150307
Carbonic anhydrase 140207
Carbonic anhydrase 5B, mitochondrial0207
Nuclear receptor subfamily 1 group I member 20033
Nuclear receptor subfamily 1 group I member 20011
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10011
Chain A, POLYMERASE PA0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Genome polyprotein 0101
bromodomain adjacent to zinc finger domain 2B3003
Replicase polyprotein 1ab0202
lysosomal alpha-glucosidase preproprotein2002
galactokinase1001
pyruvate kinase PKM isoform a1001
nuclear factor NF-kappa-B p105 subunit isoform 11012
POsterior Segregation0022
Prostaglandin E synthase0101
Telomerase reverse transcriptase0101
Polycomb protein EED0011
NAD kinase0213
Urokinase-type plasminogen activator0101
Tissue-type plasminogen activator0101
Polymerase acidic protein0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Plasminogen activator inhibitor 10101
Heme oxygenase 1 0101
Urokinase-type plasminogen activator0101
Heat shock protein HSP 90-beta0101
Neutrophil elastase0101
72 kDa type IV collagenase0101
Hepatocyte growth factor receptor0202
Matrilysin0202
60 kDa chaperonin0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Replicase polyprotein 1ab0202
Alpha-amylase 1A 0101
Apoptosis regulator Bcl-20202
Microtubule-associated protein tau0101
60 kDa heat shock protein, mitochondrial0101
Glucose-6-phosphate 1-dehydrogenase0101
Fatty acid synthase0101
CPG DNA methylase0101
Lethal factor0101
Phosphoglycerate mutase 10101
Cannabinoid receptor 10101
Heme oxygenase 20101
DNA (cytosine-5)-methyltransferase 10101
Dipeptidyl peptidase 40202
Proteasome subunit beta type-50101
Cannabinoid receptor 2 0101
Signal transducer and activator of transcription 1-alpha/beta0011
DNA repair protein RAD52 homolog0101
Fatty acid synthase0202
Matrix metalloproteinase-140101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
Squalene monooxygenase 0101
6-phosphogluconate dehydrogenase, decarboxylating0101
BH3-interacting domain death agonist0101
10 kDa heat shock protein, mitochondrial0101
Lactoperoxidase0001
Bcl-2-like protein 10202
Induced myeloid leukemia cell differentiation protein Mcl-10101
Histone acetyltransferase p3000101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Bcl-2-related protein A10101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
Sigma non-opioid intracellular receptor 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Reverse transcriptase/RNaseH 0101
10 kDa chaperonin 0101
3-oxoacyl-[acyl-carrier-protein] reductase 0101
MAP kinase-activated protein kinase 50101
Histone acetyltransferase KAT2B0101
Bcl-2-like protein 20101
Bcl2-associated agonist of cell death 0101
Histone acetyltransferase KAT50101
Enoyl-acyl-carrier protein reductase 0202
3-oxoacyl-acyl-carrier protein reductase 0101
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Bcl-2-like protein 100101
Zinc finger protein mex-50022
Chain A, PROTEIN (TRANSTHYRETIN)0011
Chain B, PROTEIN (TRANSTHYRETIN)0011
nonstructural protein 11001
histone deacetylase 9 isoform 35005
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transient receptor potential cation channel subfamily M member 20101
Potassium channel subfamily K member 20011
Androgen receptor0112
Aldo-keto reductase family 1 member C40202
Alpha-synuclein2002
Aldo-keto reductase family 1 member C30303
Transcription factor SOX-180101
Aldo-keto reductase family 1 member C2 0202
Aldo-keto reductase family 1 member C10202
Peroxisome proliferator-activated receptor alpha1001
TAR DNA-binding protein 434004
Transcriptional enhancer factor TEF-30112
Nicotinate phosphoribosyltransferase0101
Potassium channel subfamily K member 180011
Acid-sensing ion channel 50011
Acid-sensing ion channel 30101
Acid-sensing ion channel 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0404
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Integrin beta-31012
Integrin alpha-IIb1012
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50123
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 04210
Glutamate receptor ionotropic, NMDA 2B04210
Glutamate receptor ionotropic, NMDA 2C04210
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, NMDA 2D04210
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B04210
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A04210
Chain A, Glutamine Binding Protein0011
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
Asc-type amino acid transporter 10101
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10808
Serine racemase0101
Olfactory receptor 51E20022
Sodium- and chloride-dependent glycine transporter 20101
Solute carrier family 22 member 10305
Solute carrier family 22 member 20305
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
potassium voltage-gated channel subfamily H member 2 isoform d4004
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Macrophage migration inhibitory factor0202
Histamine H2 receptor0123
Histamine H1 receptor0123
Histamine H1 receptor0213
Histamine H1 receptor0224
Carbonic anhydrase0105
Carbonic anhydrase0005
Histamine H3 receptor0101
Histamine N-methyltransferase 0101
Glutaminyl-peptide cyclotransferase0202
Carbonic anhydrase 0005
Carbonic anhydrase0005
Carbonic anhydrase0005
Carbonic anhydrase 0005
Equilibrative nucleoside transporter 40001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 130004
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Histamine H3 receptor0123
Chain A, HISTIDINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Histidine-binding periplasmic protein0011
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Phospholipase A-2-activating protein0202
Type-1A angiotensin II receptor 0101
Type-1B angiotensin II receptor0202
Type-2 angiotensin II receptor0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Cationic amino acid transporter 30101
Large neutral amino acids transporter small subunit 1 0101
galanin receptor type 30101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Stromelysin-10202
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
Polyunsaturated fatty acid 5-lipoxygenase0101
Alpha-1B adrenergic receptor 0011
Alpha-2A adrenergic receptor0236
Beta-3 adrenergic receptor0224
Alpha-1B adrenergic receptor0213
Beta-1 adrenergic receptor0416
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0236
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0112
Alpha-2C adrenergic receptor0112
Alpha-2A adrenergic receptor0112
Alpha-1D adrenergic receptor0213
Alpha-2B adrenergic receptor0001
Alpha-1A adrenergic receptor0236
Alpha-1B adrenergic receptor0124
Alpha-1A adrenergic receptor0213
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Glucocorticoid receptor0224
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Voltage-dependent calcium channel subunit alpha-2/delta-10102
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Glutamate 5-kinase0001
Angiotensin-converting enzyme 0101
Beta-1 adrenergic receptor 0113
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Bile salt export pump0101
5-hydroxytryptamine receptor 40202
Cytochrome P450 1A20202
Muscarinic acetylcholine receptor M20112
5-hydroxytryptamine receptor 1A0101
Adenosine receptor A30112
Beta-2 adrenergic receptor0203
Cytochrome P450 2C80101
Cytochrome P450 2D60101
Muscarinic acetylcholine receptor M10112
D(2) dopamine receptor0112
D(3) dopamine receptor0101
Muscarinic acetylcholine receptor M30112
D(1A) dopamine receptor0112
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Endothelin-1 receptor0112
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 2A0213
5-hydroxytryptamine receptor 2C0213
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190202
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60213
5-hydroxytryptamine receptor 70101
Beta-2 adrenergic receptor0101
Potassium voltage-gated channel subfamily H member 20101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Sodium/bile acid cotransporter0202
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
Chain A, Leukotriene A-4 hydrolase0101
BRCA11001
ClpP1001
Parkin1001
P531001
pyruvate kinase1001
M18 aspartyl aminopeptidase0101
cathepsin L10101
hexokinase-4 isoform 11001
NPC intracellular cholesterol transporter 1 precursor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
glucokinase regulatory protein1001
serine/threonine-protein kinase mTOR isoform 11001
FAD-linked sulfhydryl oxidase ALR0001
Vif0101
M-phase phosphoprotein 82002
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
transcription factor p65 isoform 10011
serine/threonine-protein kinase 33 isoform a0011
Aryl hydrocarbon receptor0101
Estrogen receptor beta0011
Acetylcholinesterase0202
Lysine-specific histone demethylase 1A0101
Tyrosine-protein kinase ABL10102
Myc proto-oncogene protein0102
Estrogen receptor0101
Cytochrome P450 1A10101
Cholinesterase0202
Cathepsin D0101
Luciferin 4-monooxygenase0112
Neuronal acetylcholine receptor subunit alpha-40101
DNA polymerase alpha catalytic subunit0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Leukotriene A-4 hydrolase0101
Breakpoint cluster region protein0102
Tyrosinase0303
Aromatase0202
Ornithine decarboxylase0101
Neuronal acetylcholine receptor subunit beta-20101
Ribosyldihydronicotinamide dehydrogenase [quinone]0213
Protein kinase C alpha type0123
Tyrosine-protein phosphatase non-receptor type 10101
Estrogen receptor0011
Nuclear factor NF-kappa-B p105 subunit0101
Amine oxidase [flavin-containing] A0101
Endothelin receptor type B1001
Acetylcholinesterase0101
Endothelin-1 receptor1001
Amine oxidase [flavin-containing] B0101
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Cannabinoid receptor 10101
D(1A) dopamine receptor1001
Alpha-glucosidase MAL120101
Cholinesterase0202
Nuclear factor NF-kappa-B p100 subunit 0101
Squalene synthase0101
Transcription factor p650101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0102
Serine/threonine-protein kinase PAK 10101
Nuclear factor erythroid 2-related factor 20012
Cytochrome P450 1B10202
N1L 0101
NAD(P)H dehydrogenase [quinone] 10003
Lysosomal alpha-glucosidase0101
NAD-dependent protein deacetylase sirtuin-20011
Rap guanine nucleotide exchange factor 41001
NAD-dependent protein deacetylase sirtuin-10013
Prenyltransferase homolog0001
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
large T antigen0101
Pyruvate kinase PKM0011
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Substance-P receptor0202
Neuromedin-K receptor0011
Substance-K receptor0112
Substance-K receptor0202
Substance-P receptor0213
Neuromedin-K receptor0112
Substance-P receptor0202
Substance-K receptor0101
D(2) dopamine receptor0011
Substance-K receptor0101
Growth hormone secretagogue receptor type 10011
Mas-related G-protein coupled receptor member X20011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Acetylcholinesterase0101
Cytochrome P450 3A50101
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Retinol-binding protein 40101
Serine/threonine-protein kinase D30011
Protein kinase C gamma type0112
Protein kinase C beta type0112
Protein kinase C eta type0011
Protein kinase C iota type0011
Protein kinase C epsilon type0112
Protein kinase C theta type0011
Protein kinase C zeta type0011
Protein kinase C delta type0112
Serine/threonine-protein kinase D10011
Ras guanyl-releasing protein 30011
Cereblon isoform 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
DNA-binding protein Ikaros0001
DNA damage-binding protein 10112
Protein cereblon0214
Thymidine phosphorylase0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0112
Solute carrier organic anion transporter family member 1C10001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Myeloperoxidase0101
Indoleamine 2,3-dioxygenase 10102
Tryptophan 2,3-dioxygenase0102
SLC16A10 protein0002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Tryprostatin B synthase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Monocarboxylate transporter 100002
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Urease subunit alpha0101
Urease subunit beta0101
Ubiquitin carboxyl-terminal hydrolase 20101
Vitamin D3 receptor0112
Ileal sodium/bile acid cotransporter0101
G-protein coupled bile acid receptor 10011
CDGSH iron-sulfur domain-containing protein 10202
M1-family alanyl aminopeptidase0101
Chain A, Arginase 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]