A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
| Member | Definition | Class |
|---|
| (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside | A stilbenoid that is trans-stilbene which has been substituted by hydroxy groups at positions 2, 3, 5, and 4', and in which the hydroxy group at positon 2 has then been converted to the corresponding the beta-D-glucoside. | (E)-2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside |
| 4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl)benzenesulfonamide | A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and 4-fluorophenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine to treat pain and inflammation in dogs with degenerative joint disease. | mavacoxib |
| acetaminophen | A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. | paracetamol |
| agnuside | A benzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with the primary hydroxy group of aucubin. It is an iridoid glycoside found in several Vitex plants including Vitex agnus-castus. | agnuside |
| ahr 5850 | An organic sodium salt having amfenac(1-) as the counterion. | sodium (2-amino-3-benzoylphenyl)acetate |
| alminoprofen | A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders. | alminoprofen |
| alpha bitter acid | An optically active cyclic ketone consisting of 3,5,6-trihydroxycyclohexa-2,4-dien-1-one bearing two 3-methylbut-2-en-1-yl substituents at positions 4 and 6 as well as a 3-methylbutanoyl group at the 2-position. | humulone |
| amfenac | An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery. | amfenac |
| aspirin | A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity. | acetylsalicylic acid |
| celecoxib | A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis. | celecoxib |
| centaureidin | A trihydroxyflavone that consists of quercetagetin in which the hydroxy groups at positions 3, 6 and 4' have been replaced by methoxy groups. It has been isolated from Eremophila mitchellii and Athroisma proteiforme. | centaureidin |
| cimicoxib | An imidazole substituted at positions 1, 4 and 5 by 4-aminosulfonylphenyl, chloro and 3-fluoro-4-methyoxyphenyl groups respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs. | cimicoxib |
| cinnamtannin b-1 | A proanthocyanidin found in Cinnamomum cassia and Cinnamomum zeylanicum. | cinnamtannin B-1 |
| cox 189 | An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthritis, but was withdrawn due to concersns of hepatotoxicity. | lumiracoxib |
| dehydrocostus lactone | An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone. | dehydrocostus lactone |
| deracoxib | A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3, and 5 by 4-sulfamoylphenyl, difluoromethyl and 3-fluoro-4-methoxyphenyl groups, respectively. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in dogs. | deracoxib |
| dexketoprofen | A monocarboxylic acid that is (S)-hydratropic acid substituted at position 3 on the phenyl ring by a benzoyl group. A cyclooxygenase inhibitor, it is used to relieve short-term pain, such as muscular pain, dental pain and dysmenorrhoea. | dexketoprofen |
| etodolac | A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active. | etodolac |
| eupomatenoid 6 | A member of the class of benzofurans that is 1-benzofuran substituted by a 4-hydroxyphenyl group at position 2, a methyl group at position 3 and a prop-1-en-1-yl group at position 5. It is a lignan derivative isolated from the roots of Krameria lappacea. | rataniaphenol II |
| fenoprofen | A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding. | fenoprofen |
| fenoprofen calcium | The dihydrate form of the calcium salt of fenoprofen. A non-steroidal anti-inflammatory drug, it is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding. | fenoprofen calcium |
| firocoxib | An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoarthritis in horses and dogs. | firocoxib |
| gallic acid | A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5. | gallic acid |
| ginkgetin | A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. | ginkgetin |
| ibuprofen | A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group. | ibuprofen |
| jte 522 | A member of the class of 1,3-oxazoles that is that is 1,3-oxazole which is substituted at positions 2, 4 and 5 by methyl, cyclohexyl, and 3-fluoro-4-sulfamoylphenyl groups, respectively. | tilmacoxib |
| ketorolac | A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure. | 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid; ketorolac |
| ketorolac tromethamine | An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. | ketorolac tromethamine |
| mk 0663 | A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively. | etoricoxib |
| mobic | A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis. | meloxicam |
| n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2. | NS-398 |
| nabumetone | A methyl ketone that is 2-butanone in which one of the methyl hydrogens at position 4 is replaced by a 6-methoxy-2-naphthyl group. A prodrug that is converted to the active metabolite, 6-methoxy-2-naphthylacetic acid, following oral administration. It is shown to have a slightly lower risk of gastrointestinal side effects than most other non-steroidal anti-inflammatory drugs. | nabumetone |
| naproxen | A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. | naproxen |
| naproxen sodium | An organic sodium salt consisting of equimolar amounts of naproxen(1-) anions and sodium anions. | naproxen sodium |
| nepafenac | A monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery. | nepafenac |
| nimesulide | An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups. | nimesulide |
| nitroflurbiprofen | A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2. | nitroflurbiprofen |
| parecoxib | An N-acylsulfonamide resulting from the formal condensation of valdecoxib with propionic acid. It is a prodrug for valdecoxib. | parecoxib |
| robenacoxib | An aromatic amino acid that is 2-amino-5-ethylphenylacetic acid in which one of the amino hydrogens is replaced by a 2,3,5,6-tetrafluorophenyl group. A selective cyclooxygenase 2 inhibitor that is used in veterinary medicine for the relief of pain and inflammation in cats and dogs. | robenacoxib |
| rofecoxib | A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. | rofecoxib |
| sc 58125 | A member of the class of pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor, it exhibits anticancer property. | SC-58125 |
| sulindac sulfone | A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor. | sulindac sulfone |
| valdecoxib | A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke. | valdecoxib |
| wogonin | A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. | wogonin |
| yakuchinone-a | A ketone that is heptan-3-one substituted by a 4-hydroxy-3-methoxyphenyl group at position 1 and a phenyl group at position 7. Isolated from in Alpinia oxyphylla, it exhibits antineoplastic and inhibitory activities against COX-1, COX-2 and NO synthase. | 1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 27.4858 | 1 | 5 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 13.2436 | 2 | 7 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 54.4174 | 2 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 24.1816 | 1 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 24.4329 | 1 | 10 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 19.5498 | 1 | 3 |
| AR protein | Homo sapiens (human) | Potency | 32.9071 | 12 | 63 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 30.0515 | 2 | 10 |
| arylsulfatase A | Homo sapiens (human) | Potency | 16.2131 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 16.1982 | 4 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 35.9213 | 2 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 19.0192 | 3 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 35.1102 | 2 | 4 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 0.1510 | 1 | 1 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 19.9151 | 2 | 8 |
| BRCA1 | Homo sapiens (human) | Potency | 13.8914 | 1 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 52.1141 | 1 | 3 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 68.5896 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 52.1141 | 1 | 3 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 68.5896 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 45.5309 | 2 | 9 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 13.5718 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.5578 | 1 | 7 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 42.1514 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 35.7168 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 26.2494 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 15.1011 | 3 | 7 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 14.6340 | 2 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 9.9253 | 2 | 7 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 26.2494 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 61.7846 | 2 | 11 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 0.0794 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 17.6577 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 15.4576 | 1 | 14 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 20.8707 | 1 | 11 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 0.0501 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 18.6815 | 2 | 18 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 20.1635 | 2 | 19 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 35.7778 | 1 | 7 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 63.2291 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 20.2229 | 1 | 4 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 26.5942 | 12 | 73 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 44.2739 | 3 | 8 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 34.5500 | 9 | 69 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 10.5446 | 1 | 12 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.7833 | 4 | 25 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 34.2871 | 2 | 5 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 19.4200 | 1 | 2 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 19.9526 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 15.4576 | 1 | 14 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 18.6815 | 1 | 9 |
| geminin | Homo sapiens (human) | Potency | 8.0783 | 2 | 13 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 18.7150 | 3 | 19 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 14.9248 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 25.9932 | 2 | 9 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 1.9514 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 24.6483 | 5 | 17 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 46.7139 | 2 | 10 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 54.9770 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 17.6577 | 1 | 9 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 27.8298 | 1 | 2 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 11.5688 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 48.8908 | 2 | 5 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 15.4576 | 1 | 14 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 31.3540 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 34.8946 | 2 | 6 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 9.6704 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 16.4334 | 1 | 5 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 15.4576 | 1 | 28 |
| inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.7509 | 2 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 15.7230 | 3 | 21 |
| interleukin 8 | Homo sapiens (human) | Potency | 61.1430 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.3878 | 1 | 9 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 16.8780 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 25.3303 | 3 | 16 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 9.3371 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.3768 | 2 | 11 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 32.5218 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.1639 | 2 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 14.2671 | 1 | 4 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 12.6714 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 8.4719 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 6.5704 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 31.5342 | 3 | 26 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 12.7706 | 1 | 4 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 40.1995 | 2 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 21.0120 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 18.1488 | 2 | 9 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 22.9640 | 3 | 19 |
| P53 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 37.9330 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 18.1749 | 1 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 90.1024 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 28.1967 | 4 | 17 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.8061 | 5 | 11 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 32.5733 | 1 | 2 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 7.0795 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 28.4299 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 14.5552 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 20.1777 | 3 | 14 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 44.6641 | 3 | 14 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 36.4261 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 22.4864 | 2 | 23 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 3.2405 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 4.3680 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 30.5060 | 3 | 30 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 9.8839 | 3 | 14 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 20.5779 | 2 | 9 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 20.5779 | 2 | 9 |
| Smad3 | Homo sapiens (human) | Potency | 16.8669 | 1 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 24.9334 | 1 | 7 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 18.2396 | 1 | 7 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 24.4727 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 22.3050 | 2 | 24 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 56.2341 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 19.4152 | 3 | 10 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 42.0415 | 3 | 12 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 16.0138 | 4 | 20 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 36.2228 | 2 | 2 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 7.0795 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 7.0795 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 40.7584 | 2 | 8 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 36.8380 | 2 | 9 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 15.6655 | 2 | 9 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 58.5077 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 48.3907 | 1 | 9 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens (human) | IC50 | 48.0000 | 2 | 2 |
| 4-aminobutyrate aminotransferase, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 1.7500 | 1 | 4 |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 350.0000 | 1 | 1 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | Ki | 37.3000 | 1 | 3 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 235.1100 | 1 | 1 |
| Acid-sensing ion channel 1 | Rattus norvegicus (Norway rat) | IC50 | 288.0192 | 5 | 9 |
| Acid-sensing ion channel 3 | Rattus norvegicus (Norway rat) | IC50 | 512.8610 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 1,422.3000 | 2 | 5 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 8.2600 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 1,774.5000 | 1 | 4 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 6.5500 | 2 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 24.6220 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 13.9170 | 1 | 1 |
| Albumin | Bos taurus (cattle) | IC50 | 3.0000 | 1 | 1 |
| Albumin | Homo sapiens (human) | Ki | 130,008,200,000.0000 | 1 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 4.0343 | 1 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 4.0010 | 1 | 3 |
| Aldo-keto reductase family 1 member C1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 16.2800 | 2 | 2 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 8.9520 | 4 | 5 |
| Aldo-keto reductase family 1 member C4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Alpha-(1,3)-fucosyltransferase 7 | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 24.6220 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 13.9170 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 24.6220 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 13.9170 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.5160 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.6920 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 4.4300 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 0.9980 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 13.2000 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 7,700.0000 | 1 | 1 |
| Anthrax toxin receptor 2 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | IC50 | 44.0000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 9.4533 | 3 | 3 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 11 |
| Autoinducer 2-binding periplasmic protein LuxP | Vibrio harveyi | IC50 | 50.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 16.1240 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 12.0930 | 1 | 1 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 11.6600 | 3 | 6 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 4.1800 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 87.7133 | 2 | 3 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 272.9517 | 4 | 24 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 645.4500 | 1 | 2 |
| C-X-C chemokine receptor type 1 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Calpain-2 catalytic subunit | Homo sapiens (human) | IC50 | 0.0110 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 10 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 1.1135 | 3 | 8 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 4.1300 | 1 | 1 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 0.3800 | 2 | 4 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ki | 49.7500 | 1 | 2 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ki | 0.3810 | 1 | 2 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 3.2000 | 1 | 2 |
| Carbonic anhydrase | Anopheles gambiae (African malaria mosquito) | Ki | 0.1685 | 1 | 2 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 0.6245 | 1 | 2 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 1.8800 | 1 | 2 |
| Carbonic anhydrase | Mycobacterium tuberculosis H37Rv | Ki | 7.7850 | 1 | 2 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 0.1065 | 1 | 2 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.0314 | 2 | 4 |
| Carbonic anhydrase | Sulfurihydrogenibium sp. YO3AOP1 | Ki | 0.0061 | 1 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 237.1303 | 5 | 13 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 158.8029 | 46 | 94 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 74.1373 | 10 | 26 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 0.2070 | 2 | 3 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 130.4057 | 4 | 15 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 113.8009 | 5 | 17 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 1.2704 | 4 | 8 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 87.9732 | 6 | 15 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 67.3355 | 56 | 111 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 0.6975 | 2 | 4 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 159.3416 | 6 | 19 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | IC50 | 14.1776 | 3 | 11 |
| Carbonic anhydrase 4 | Bos taurus (cattle) | Ki | 0.3150 | 2 | 4 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 88.3155 | 8 | 22 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 160.2400 | 5 | 17 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 130.6908 | 5 | 17 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 112.2536 | 7 | 23 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 81.6371 | 9 | 24 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 0.0204 | 3 | 5 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 51.4164 | 19 | 41 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 0.7550 | 1 | 2 |
| Carboxypeptidase B2 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 18.8673 | 1 | 15 |
| Caspase-3 | Homo sapiens (human) | IC50 | 18.8673 | 1 | 15 |
| Caspase-4 | Homo sapiens (human) | IC50 | 18.8673 | 1 | 15 |
| Caspase-5 | Homo sapiens (human) | IC50 | 18.8673 | 1 | 15 |
| Caspase-9 | Homo sapiens (human) | IC50 | 18.8673 | 1 | 15 |
| Catechol O-methyltransferase | Mus musculus (house mouse) | IC50 | 4.5240 | 2 | 3 |
| CDK-activating kinase assembly factor MAT1 | Homo sapiens (human) | IC50 | 12.3000 | 1 | 1 |
| Cell division control protein 42 homolog | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 68.5000 | 2 | 2 |
| Chain A, Carbonic anhydrase II | Homo sapiens (human) | IC50 | 0.0210 | 1 | 1 |
| Chain A, Carbonic anhydrase II | Homo sapiens (human) | Ki | 0.0430 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 600.0000 | 1 | 1 |
| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| Cruzipain | Trypanosoma cruzi | IC50 | 263.0000 | 2 | 2 |
| Cyclin-A2 | Homo sapiens (human) | IC50 | 1.4600 | 1 | 1 |
| Cyclin-C | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 1.4600 | 2 | 2 |
| Cyclin-dependent kinase 7 | Homo sapiens (human) | IC50 | 12.3000 | 1 | 1 |
| Cyclin-dependent kinase 8 | Homo sapiens (human) | IC50 | 5.9000 | 1 | 1 |
| Cyclin-dependent kinase 9 | Homo sapiens (human) | IC50 | 0.1920 | 4 | 4 |
| Cyclin-H | Homo sapiens (human) | IC50 | 12.3000 | 1 | 1 |
| Cyclin-T1 | Homo sapiens (human) | IC50 | 0.1927 | 3 | 3 |
| Cyclooxygenase-2 | Canis lupus familiaris (dog) | IC50 | 0.7650 | 1 | 2 |
| Cytochrome c oxidase subunit 1 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Cytochrome c oxidase subunit 1 | Ovis aries (sheep) | IC50 | 38.5625 | 4 | 4 |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | IC50 | 0.8722 | 5 | 6 |
| Cytochrome c oxidase subunit 2 | Ovis aries (sheep) | IC50 | 0.0882 | 4 | 4 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 40.0000 | 2 | 4 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 5.5000 | 2 | 2 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 27.9940 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 13.9970 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 10.2150 | 2 | 2 |
| Dehydrogenase/reductase SDR family member 9 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Delta carbonic anhydrase | Conticribra weissflogii | Ki | 0.3215 | 1 | 2 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 26.0160 | 2 | 4 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0320 | 1 | 2 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 3,120.0000 | 1 | 3 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 4.6500 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| E-selectin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | IC50 | 9.8530 | 1 | 1 |
| Endothelin-1 receptor | Homo sapiens (human) | Ki | 6.0640 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 2 |
| Estrogen receptor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Fatty acid-binding protein, intestinal | Homo sapiens (human) | Ki | 136.4500 | 1 | 2 |
| Fatty acid-binding protein, liver | Rattus norvegicus (Norway rat) | Ki | 792.3667 | 2 | 6 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 100.6667 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 44.4833 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 2.0417 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 57.9000 | 1 | 1 |
| Glutathione hydrolase 1 proenzyme | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | Ki | 6.1000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 1.4110 | 2 | 2 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 1.1400 | 2 | 2 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Hormone-sensitive lipase | Rattus norvegicus (Norway rat) | IC50 | 1.2000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 0.0060 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | IC50 | 52.5000 | 2 | 2 |
| Integrin beta-3 | Homo sapiens (human) | IC50 | 52.5000 | 2 | 2 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 23.3450 | 1 | 1 |
| L-selectin | Homo sapiens (human) | IC50 | 27.6000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 388.6667 | 3 | 3 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 50.0115 | 2 | 2 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 8.8700 | 1 | 1 |
| Matrilysin | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 13.8250 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 0.6700 | 2 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 36.8667 | 1 | 3 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0320 | 1 | 2 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 52.0000 | 1 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 113.8818 | 1 | 11 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 101.0500 | 2 | 2 |
| Myoglobin | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 26.6100 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 26.6100 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0005 | 1 | 1 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 28.9000 | 2 | 2 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 34.9850 | 1 | 1 |
| Nuclear receptor subfamily 4 group A member 2 | Homo sapiens (human) | IC50 | 13.4000 | 1 | 1 |
| P-selectin | Homo sapiens (human) | IC50 | 19.1000 | 1 | 1 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| Plasminogen activator inhibitor 1 | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 1.6370 | 1 | 1 |
| Polypeptide N-acetylgalactosaminyltransferase 2 | Homo sapiens (human) | IC50 | 1.3700 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 13.9843 | 6 | 7 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 43.6667 | 2 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 28.3800 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 1.2400 | 1 | 2 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 30.0000 | 1 | 2 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 11.7093 | 7 | 7 |
| Prostaglandin E synthase | Mus musculus (house mouse) | IC50 | 0.0070 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Canis lupus familiaris (dog) | IC50 | 14.2850 | 1 | 2 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 69.0593 | 121 | 196 |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | IC50 | 8.7259 | 11 | 12 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 286.8304 | 193 | 293 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | Ki | 62.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Ki | 9.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 626.2809 | 11 | 23 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 17.6522 | 7 | 9 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 72.2265 | 270 | 394 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 | 6.0054 | 27 | 34 |
| Prostaglandin G/H synthase 2 | Oryctolagus cuniculus (rabbit) | IC50 | 18.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 101.8724 | 93 | 144 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | Ki | 8.7432 | 3 | 6 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | Ki | 4.7450 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 333.5986 | 5 | 9 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 10.5131 | 8 | 10 |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | IC50 | 500.1333 | 2 | 3 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 7,100.0000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 3 | Homo sapiens (human) | IC50 | 25.8000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 2.0100 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | Ki | 3.5300 | 1 | 1 |
| Quinolone resistance protein NorA | Staphylococcus aureus | IC50 | 40.0000 | 1 | 1 |
| Ras-related C3 botulinum toxin substrate 1 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 32.7000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 32.7000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 32.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 32.2333 | 3 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 30.2000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 30.2000 | 2 | 2 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 3,400.0000 | 2 | 2 |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 22.7367 | 1 | 6 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0500 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 8.6575 | 1 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 6.8785 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 4.0343 | 1 | 3 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 4.0010 | 1 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 6.2760 | 1 | 1 |
| Sodium-dependent serotonin transporter | Macaca mulatta (Rhesus monkey) | IC50 | 0.5000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 3.3340 | 1 | 1 |
| Sodium/hydrogen exchanger 1 | Rattus norvegicus (Norway rat) | IC50 | 33.1000 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 51.3878 | 1 | 4 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 21.2667 | 1 | 3 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 347.0521 | 1 | 4 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 526.5000 | 2 | 5 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 1,170.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 126.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 2,430.0000 | 1 | 1 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 | 73.0000 | 1 | 1 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.5250 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 1.7500 | 1 | 2 |
| Tissue-type plasminogen activator | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Toll-like receptor 2 | Mus musculus (house mouse) | IC50 | 69.2500 | 1 | 1 |
| Transcriptional activator Myb | Gallus gallus (chicken) | IC50 | 9.5450 | 1 | 2 |
| Transporter | Macaca mulatta (Rhesus monkey) | IC50 | 100.0000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 2,800.0000 | 3 | 3 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Escherichia coli K-12 | IC50 | 50.0000 | 1 | 1 |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Pseudomonas aeruginosa PAO1 | IC50 | 50.0000 | 1 | 1 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Urokinase-type plasminogen activator | Mus musculus (house mouse) | IC50 | 6.6000 | 1 | 1 |
| Urotensin-2 receptor | Rattus norvegicus (Norway rat) | IC50 | 3.9500 | 1 | 4 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 176.1000 | 1 | 1 |