ascorbic-acid and Tuberculosis--Pulmonary

Henoch-Schönlein purpura (HSP) is an extremely rare condition in patients with pulmonary tuberculosis, with only a few reported cases. Compared to patients with typical clinical symptoms, it is difficult to make a definitive diagnosis when HSP presents as an initial manifestation in pulmonary tuberculosis patients. Herein, a case of pulmonary tuberculosis that showed HSP at first was reported, and the related literatures were reviewed.. A 24-year-old man presented with palpable purpura on the extremities, accompanied by abdominal pain, bloody stools, and knee pain.. The patient was diagnosed with pulmonary tuberculosis based on the results of interferon gamma release assays, purified protein derivative test, and computed tomography.. The patient was treated with vitamin C and chlorpheniramine for 2 weeks, and the above-mentioned symptoms were relieved. However, 3 weeks later, the purpura recurred with high-grade fever and chest pain during the inspiratory phase. The patient was then treated with anti-tuberculosis drugs, and the purpura as well as the high fever disappeared.. The patient recovered well and remained free of symptoms during the follow-up examination.. Pulmonary tuberculosis presenting with HSP as an initial manifestation is not common. Therefore, it is difficult to clinically diagnose and treat this disease. When an adult patient shows HSP, it is important to consider the possibility of tuberculosis to avoid misdiagnosis and delayed treatment.

Topics: Abdominal Pain; Aftercare; Antitubercular Agents; Ascorbic Acid; Chlorpheniramine; Diagnosis, Differential; Fever; Gastrointestinal Hemorrhage; Histamine H1 Antagonists; Humans; IgA Vasculitis; Interferon-gamma Release Tests; Male; Treatment Outcome; Tuberculin; Tuberculosis, Pulmonary; Vitamins; Young Adult

HIV and TB infections are both associated with elevated oxidative stress parameters. Anti-oxidant supplementation may offer beneficial effects in positively modulating oxidative stress parameters in HIV and HIV-TB infected patients. We investigated the effects of vitamin A and C supplementation on oxidative stress in HIV infected and HIV-TB co-infected subjects.. 40 HIV/TB co-infected and 50 HIV mono-infected patients were divided into 2 equal groups. Participants provided demographic information and blood was collected to determine oxidative stress parameters before and after vitamin A (5000 IU) and C (2600 mg) supplementation for 1 month.. There was a significantly (p < 0.05) higher level of Malondialdehyde (MDA) at baseline for HIV infected subjects compared with HIV-TB co-infected subjects. There was a significantly (p < 0.05) lower level of MDA and higher level of Catalase (CAT) in subjects administered supplementation compared to subjects without supplementation for the HIV infected group. There was a significantly lower level of Reduced Glutathione (GSH), Superoxide Dismutase (SOD) and higher level of MDA after one month of supplementation compared with baseline levels for HIV/TB co infected subjects. A similar result was also obtained for the HIV mono-infected groups which had a significantly lower level of SOD, MDA and CAT compared to the baseline. There was a significantly lower level of GSH and SOD, and higher level of MDA after supplementation compared with the baseline for HIV/TB co-infected subjects. Comparing the indices at baseline and post no-supplementation in HIV/TB co-infection showed no significant differences in the oxidative stress parameters.. HIV/TB co-infection and HIV mono-infection seems to diminish the capacity of the anti-oxidant system to control oxidative stress, however exogenous anti-oxidant supplementation appears not to have beneficial roles in positively modulating the associated oxidative stress.

Topics: Adult; Ascorbic Acid; Catalase; Coinfection; Dietary Supplements; Female; Glutathione; HIV Infections; Hospitals, Teaching; Humans; Male; Malondialdehyde; Middle Aged; Nigeria; Oxidative Stress; Superoxide Dismutase; Tuberculosis, Pulmonary; Vitamin A; Vitamins; Young Adult

The development of low-cost point-of-care technologies to improve HIV treatment is a major focus of current research in resource-limited settings.. We assessed associations of body mass index (BMI; in kg/m(2)) at antiretroviral therapy (ART) initiation and weight change after 1 mo of treatment with mortality, morbidity, and CD4 T cell reconstitution.. A prospective cohort of 3389 Tanzanian adults initiating ART enrolled in a multivitamin trial was followed at monthly clinic visits (median: 19.7 mo). Proportional hazard models were used to analyze mortality and morbidity associations, whereas generalized estimating equations were used for CD4 T cell counts.. The median weight change at 1 mo of ART was +2.0% (IQR: -0.4% to +4.6%). The association of weight loss at 1 mo with subsequent mortality varied significantly by baseline BMI (P = 0.011). Participants with ≥2.5% weight loss had 6.43 times (95% CI: 3.78, 10.93 times) the hazard of mortality compared with that of participants with weight gains ≥2.5%, if their baseline BMI was <18.5 but only 2.73 times (95% CI: 1.49, 5.00 times) the hazard of mortality if their baseline BMI was ≥18.5 and <25.0. Weight loss at 1 mo was also associated with incident pneumonia (P = 0.002), oral thrush (P = 0.007), and pulmonary tuberculosis (P < 0.001) but not change in CD4 T cell counts (P > 0.05).. Weight loss as early as 1 mo after ART initiation can identify adults at high risk of adverse outcomes. Studies identifying reasons for and managing early weight loss are needed to improve HIV treatment, with particular urgency for malnourished adults initiating ART. The parent trial was registered at clinicaltrials.gov as NCT00383669.

Topics: Adult; Antiretroviral Therapy, Highly Active; Ascorbic Acid; Body Mass Index; CD4 Lymphocyte Count; Double-Blind Method; Female; HIV Infections; Humans; Male; Middle Aged; Morbidity; Multivariate Analysis; Pneumonia; Proportional Hazards Models; Prospective Studies; Tanzania; Treatment Outcome; Tuberculosis, Pulmonary; Viral Load; Vitamin B Complex; Vitamin E; Vitamins; Weight Loss

to evaluate the effect of ascorbic acid and emoxypin on the efficiency of complex chemotherapy for infiltrative pulmonary tuberculosis.. One hundred patients with infiltrative pulmonary tuberculosis in a phase of decay were examined. The patients were divided into 3 groups. Group 1 received the standard therapy (n = 34); Groups 2 (n = 33) and 3 (n = 33) had additionally daily intravenous dropwise infusions of ascorbic acid (500 mg) (OAO "Novosibkhimpharm") or emoxypin (150 mg) (Moscow Endocrine Plant). The drugs were injected for 10 days. Therapeutic efficiency was evaluated during 12 months.. Additional use of ascorbic acid decreased the likelihood of progression of the disease to fibrocavernous tuberculosis and promotes a good completion of 12-month course of therapy providing small posttuberculous changes. The administration of emoxypin contributes to eradication of Mycobacterium tuberculosis, reduces the time of decay cavity closure and a need for surgical treatment of pulmonary tuberculosis.. The findings show it expedient to include ascorbic acid and emoxypin into the combined treatment regimen for infiltrative tuberculosis in a phase of decay.

Topics: Adult; Antitubercular Agents; Ascorbic Acid; Drug Therapy, Combination; Female; Humans; Male; Picolines; Pulmonary Circulation; Pulmonary Fibrosis; Tuberculosis, Pulmonary

The aim of this prospective placebo-controlled randomized study was to assess the effectiveness of ascorbic acid or emoxipin in the regimen of the therapy of infiltrative pulmonary tuberculosis. Emoxipin vs. ascorbic acid favored the eradication of tuberculosis mycobacteria. Both preparations decreased the blood level of the contra-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha), shortened time to the closure of degeneration cavities in tubercular infiltrations, decreased the risk of the development of destructive forms, and lowered the need for surgical interventions for infiltrative pulmonary tuberculosis.

Topics: Adult; Antioxidants; Ascorbic Acid; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunoenzyme Techniques; Infusions, Intravenous; Male; Mycobacterium tuberculosis; Picolines; Prospective Studies; Sputum; Treatment Outcome; Tuberculosis, Pulmonary; Tumor Necrosis Factor-alpha; Vitamins

Plasma antioxidative activity was determined by spectrophotometric method by estimation of plasma volume resulting in inhibition of free radical reaction rate by 50%. The study comprised 40 patients with pulmonary tuberculosis (25 men, 15 women) aged 19-77 years (mean 48.5). Every patient had infiltrative pulmonary tuberculosis diagnosed. After 1-month therapy with tuberculostatic drugs vitamins C and E were added in 15 patients in a daily dose of 1.0 g and 600 mg respectively. The control group consisted of 16 clinically healthy subjects (12 men, 4 women) aged 28-57 years (mean 42.5). Decrease in plasma antioxidative activity was found in patients as compared to the controls before as well as after therapy with tuberculostatic drugs. However, in patients with added vitamins (after 1-month tuberculostatic therapy) increase in plasma antioxidant activity was observed.

Topics: Adult; Aged; Antioxidants; Antitubercular Agents; Ascorbic Acid; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Plasma; Spectrophotometry; Tuberculosis, Pulmonary; Vitamin E

Topics: Adult; Ascorbic Acid; Clinical Trials as Topic; Dihydrostreptomycin Sulfate; Drug Eruptions; Eosinophilia; Female; Headache; Humans; Male; Middle Aged; Streptomycin; Sulfates; Tinnitus; Tuberculosis, Pulmonary; Vertigo

Malnutrition is associated with an increased risk of pulmonary tuberculosis (PTB) treatment failure. Currently, there is no effective adjunctive nutritional therapy. The current objective is to investigate the association of dietary micronutrient intake with PTB treatment outcome.A cohort study including 1834 PTB patients was conducted in Linyi, China. The dietary micronutrient intake was assessed through a three-day 24 h dietary recall questionnaire. The treatment outcome was assessed by combinations of sputum smear and computerized tomography results. A multivariate binary regression model was used to assess the associations. The final model was adjusted for potential confounding factors. A low intake of vitamin C (adjusted OR (95% CI): 1.80 (1.07, 3.04), P

Topics: Adult; Ascorbic Acid; China; Cohort Studies; Dietary Supplements; Eating; Female; Humans; Male; Manganese; Middle Aged; Nutritional Physiological Phenomena; Surveys and Questionnaires; Treatment Failure; Tuberculosis, Pulmonary; Zinc

Chronic inflammation, possibly exacerbated by cigarette smoking, is considered to be the primary cause of pulmonary damage in patients with tuberculosis (TB). However, the mechanisms which underpin these harmful inflammatory responses, have not been well documented.. The current study was undertaken to determine possible associations between systemic biomarkers of inflammation (acute phase reactants, stress hormones, leukocyte vitamin C) and smoking status in patients (n=71, 20 smokers) with newly-diagnosed pulmonary TB presenting at a tertiary hospital, Johannesburg, South Africa.. Plasma concentrations of C-reactive protein (CRP), ferritin, cortisol, epinephrine, norepinephrine, dopamine and leukocyte vitamin C were measured using a combination of immunonephelometric, radioimmunoassay, immunochromatographic and spectrophotometric procedures. Demographic, clinical and laboratory data was captured and analysed by parametric and non-parametric analyses where appropriate.. Smokers were predominantly males (P<0.0001), of older age (P<0.0003) with a significantly lower body mass index (P<0.03). Plasma levels of CRP, ferritin and dopamine were higher in the group of smokers in the setting of lower levels of epinephrine, and leukocyte vitamin C, with CRP and vitamin C attaining statistical significance (P<0.04 and P<0.02 respectively). Those of cortisol and norepinephrine were comparable to those of non-smokers, as were radiographic changes and clinical indices of disease activity.. Cigarette smoking is associated with an exaggerated systemic inflammatory response in pulmonary TB in the setting of decreased concentrations of leukocyte vitamin C. Although no significant associations with radiographic changes and most clinical indices of disease activity were evident on presentation, these pro-inflammatory interactions may have prognostic significance.

Topics: Adult; Ascorbic Acid; Biomarkers; C-Reactive Protein; Dopamine; Epinephrine; Female; Ferritins; Humans; Hydrocortisone; Inflammation; Leukocytes; Male; Middle Aged; Norepinephrine; Smoking; South Africa; Tuberculosis, Pulmonary

Rhodococcus equi infection is increasing in regions with high HIV prevalence worldwide. The microbiological features and clinical mimicry of tuberculosis infection pose diagnostic challenges in high-tuberculosis-incidence settings. We present two HIV-associated cases of R. equi infection from Vietnam and discuss the unique diagnostic challenges in such settings.

Topics: Actinomycetales Infections; Adult; Anti-Bacterial Agents; Anti-HIV Agents; Ascorbic Acid; Cholecalciferol; Dehydroepiandrosterone; HIV Infections; Humans; Male; Nicotinic Acids; Plant Extracts; Rhodococcus equi; Tuberculosis, Pulmonary; Vietnam

This case-control study followed by a longitudinal cohort study was undertaken to evaluate the level of lipid peroxidation product malondialdehyde (MDA) and nitrite as an indirect measurement of nitric oxide vis-à-vis the levels of antioxidants vitamin C and vitamin E in pulmonary tuberculosis. Fifty-six sputum smear-positive cases of pulmonary tuberculosis based on Ziehl-Neelsen (ZN) staining and 50 healthy controls without any systemic disease were included in this study. Thirty-five cases were longitudinally followed up with standard antituberculosis chemotherapy (ATT) for two months. Serum levels of malondiadehyde (MDA), nitrite, and plasma levels of vitamins C and E were measured. The mean serum MDA level was significantly higher (8.1 +/- 1.61 nmoles/ml) in PTB patients before commencement of ATT as compared to healthy controls (3.45 +/- 1.7 nmoles/ml) (p=0.0001) and decreased significantly after 2 months of ATT (3.84 +/- 1.28 nmoles/ml) (p=0.0001). The mean serum nitrite level (47.19 +/- 18.44 micromol/l) was significantly elevated before ATT compared to healthy controls (32.89 +/- 11.94 micromoles/l) and decreased significantly after 2 months of ATT (27.71 +/- 11.97 micromoles/l) (p=0.0001). The mean plasma levels of vitamins C (0.88 +/- 0.33 mg/dl) and E (0.79 +/- 0.24 mg/dl) in PTB patients before commencement of ATT were lower than healthy controls (1.42 +/- 0.38 mg/dl) and (1.35 +/- 0.35 mg/dl), respectively (p=0.001). There was a significant increase in vitamin C levels after 2 months of ATT (1.19 +/- 0.40 mg/dl) compared to before ATT (0.83 +/- 0.31 mg/dl) (p=0.0001), but no significant change in mean plasma vitamin E level before and after 2 months on ATT was found. Elevated malondialdehyde and nitrite levels with concomitant depressed vitamin C and E levels are indicative of lipid peroxidation and oxidative stress. The decrease in levels of malondialdehyde and nitrite with subsequent increase in vitamin C levels after two months of follow-up indicate a good response to treatment with standard ATT. Hence, the extent of oxidative stress in PTB can be evaluated by analyzing lipid peroxidation product, antioxidant and nitric oxide levels.

Topics: Adult; Antioxidants; Ascorbic Acid; Cohort Studies; Female; Follow-Up Studies; Humans; Lipid Peroxidation; Longitudinal Studies; Male; Malondialdehyde; Middle Aged; Nepal; Nitric Oxide; Sputum; Tuberculosis, Pulmonary; Vitamin E

Ascorbic acid plays a major role in pulmonary antioxidant defense. Sufficient amounts of ascorbic acid are necessary to maintain normal metabolic processes in the lung. We measured the levels of ascorbic, dehydroascorbic and diketogulonic acids in blood serum of patients with pulmonary tuberculosis (PTB) and pneumonia. The serum levels of ascorbic acid were decreased in PTB and pneumonia, and those of dehydroascorbic acid were decreased in PTB, but not in pneumonia. The serum diketogulonic acid levels were not significantly changed in either PTB or pneumonia. The ratio of ascorbic to dehydroascorbic acid levels in serum were increased in PTB, but in pneumonia we observed a significant decrease in this index. The ratio of dehydroascorbic to diketogulonic acid in PTB was decreased, but in pneumonia this index did not significantly differ from the control value. Thus, in PTB the rate of ascorbic acid oxidation is decreased and the rate of dehydroascorbic acid oxidation is increased. By contrast, in pneumonia the rate of ascorbic acid oxidation is increased, but the rate of dehydroascorbic acid oxidation did not differ from control values.

Topics: 2,3-Diketogulonic Acid; Adult; Ascorbic Acid; Case-Control Studies; Dehydroascorbic Acid; Female; Humans; Male; Pneumonia; Tuberculosis, Pulmonary

To examine whether vitamin C rich food consumption and related vitamin C intake are associated with the risk of tuberculosis, the authors analyzed 167 incident cases of tuberculosis during a median follow-up time of 6.7 years in a clinical trial cohort of 26,975 Finnish men for whom they had baseline dietary data. A highly statistically significant inverse association between calculated vitamin C intake and the incidence of tuberculosis was found, but adjustment for non-dietary factors weakened the association to nonsignificant. Furthermore, the risk of tuberculosis decreased with increasing intake of fruits, vegetables, and berries independent of vitamin C intake. Subjects who had dietary vitamin C intake >90 mg/day and who consumed more than the average amount of fruits, vegetables, and berries had a significantly lower risk of tuberculosis (adjusted relative risk = 0.40; 95% confidence interval 0.24, 0.69). Associations between dietary vitamin C intake and occurrence of various diseases without proper control of confounding have often been interpreted as causal. These findings show that such associations can be confounded even by some other dietary components. Lower tuberculosis incidence in subjects who consumed more fruits, vegetables, and berries poor in vitamin C suggests that other compounds in such a diet may reduce the risk of tuberculosis.

Topics: Aged; Ascorbic Acid; Cohort Studies; Confounding Factors, Epidemiologic; Diet; Diet Surveys; Finland; Humans; Incidence; Male; Middle Aged; Proportional Hazards Models; Risk Factors; Smoking; Tuberculosis, Pulmonary

Inflammation-related oxidative stress has been implicated in the pathogenesis of lung fibrosis and dysfunction in patients with pulmonary tuberculosis.. To investigate the effects of antimicrobial chemotherapy and smoking status on the plasma concentrations of the anti-oxidative nutrients vitamin C, vitamin E and beta-carotene, as well as those of iron, lipid peroxides and the acute phase reactants C-reactive protein (CRP) and ferritin.. A total of 41 patients with active pulmonary tuberculosis were studied at the outset and after 6 months of antimicrobial chemotherapy.. Initial plasma concentrations of vitamin C and beta-carotene were low, returning to normal values after chemotherapy in the non-smokers, but not in the smokers, while those of vitamin E remained low throughout in both groups. Ferritin and CRP concentrations decreased significantly following chemotherapy, with the former higher in smokers than in non-smokers. Serum lipid peroxides were elevated in patients with pulmonary tuberculosis and were unaffected by chemotherapy or smoking habits, while iron levels were not significantly affected by chemotherapy. Although residual dysfunction and infiltration were evident, pulmonary function (FEV1) and radiographic score improved equally in both smokers and non-smokers following antimicrobial chemotherapy.. Even after 6 months of apparently successful antimicrobial chemotherapy, pulmonary tuberculosis is associated with increased oxidative stress, which is unrelated to cigarette smoking and characterized by increased levels of circulating lipid peroxides and low concentrations of plasma vitamin E.

Topics: Acute-Phase Proteins; Adult; Antioxidants; Antitubercular Agents; Ascorbic Acid; beta Carotene; Female; Humans; Iron; Lipid Peroxides; Male; Middle Aged; Oxidative Stress; Respiratory Function Tests; Smoking; Tuberculosis, Pulmonary; Vitamin E

Topics: Adult; Ascorbic Acid; Female; Humans; Male; Middle Aged; Neutrophils; Phagocytosis; Tuberculosis, Pulmonary

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Female; Humans; Male; Middle Aged; Tuberculosis, Pulmonary

Fifty-six tuberculosis patients and twenty-eight control subjects were evaluated in a comprehensive investigation of cellular and humoral immune function in pulmonary TB. The patient group showed significantly higher levels of secretory IgA and serum IgG, IgA and IgM than did the control group but 7% of patients displayed a selective secretory IgA deficiency. Levels of alpha-1-antitrypsin were also significantly higher in the patient group. There were no significant differences in levels of total haemolytic complement, C'3 and C'4. In moderate to moderately advanced TB patients there were no significant differences in T and B cell numbers nor in mitogen-induced lymphocyte transformation and lymphokine production, when compared with the control group. The range of PPD-induced lymphocyte transformation and lymphokine production levels encountered was similar in both groups although certain patients did not respond to the PPD antigen. Neutrophils from TB patients showed increased random motility in vitro but eight out of ten patients showed impaired directed motility (chemotaxis). Phagocytic and anti-microbial functions were normal in the patient group. The neutrophil chemotactic defect was reversible and could be corrected in vitro when the patients' cells were treated with sodium and calcium ascorbate, levamisole, metoprolol and propranolol.

Topics: Antibody Formation; Ascorbic Acid; Chemotaxis, Leukocyte; Humans; Immunity, Cellular; Immunoglobulin A, Secretory; Immunoglobulins; Leukocyte Migration-Inhibitory Factors; Levamisole; Lymphocytes; Metoprolol; Neutrophils; Propanolamines; Propranolol; Tuberculosis, Pulmonary

Topics: Adolescent; Adult; Aged; Arctic Regions; Ascorbic Acid; Cold Climate; Female; Humans; Male; Middle Aged; Seasons; Siberia; Tuberculosis, Pulmonary; Vitamin B Complex; Vitamin D

Topics: Adult; Ascorbic Acid; B-Lymphocytes; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Pyridoxine; T-Lymphocytes; Thiamine; Tuberculosis, Pulmonary

The unusual occurrence of microcytic anemia with hypochromia, high iron blood levels and excess of sideroblasts in the bone marrow, observed during the treatment of tuberculosis with isoniazid and rifampicine is reported. Three particularities were noted. First, in our experience, the occurrence of this type of anemia has never been noted previously as a result of these two drugs. Secondly, the improvement of the blood abnormalities was obtained by the combined use of vitamin B6 and vitamin C. Thirdly, the anemia was associated with neuropathy, characterized by areflexia and dysesthesia, which improved with vitamin B6 therapy (but not with vitamin C). Some mechanisms are discussed as being possibly the origin of this kind of anemia, particularly a lack of vitamin B6 resulting from a massive urinary loss of pyridoxal induced by isoniazid as well as both a tissue depletion and an overconsumption of this vitamin. The anemia may be the consequence of a deficiency of hemoglobin synthesis involving probably the first step of the biosynthesis of heme.

Topics: Aged; Anemia, Sideroblastic; Antitubercular Agents; Ascorbic Acid; Female; Humans; Isoniazid; Pyridoxine; Rifampin; Tuberculosis, Pulmonary

Topics: Adult; Alcoholism; Ascorbic Acid; Humans; Male; Middle Aged; Tuberculosis, Pulmonary

Topics: Age Factors; Aged; Ascorbic Acid; Female; Humans; Male; Middle Aged; Tuberculosis, Pulmonary

Topics: Antitubercular Agents; Ascorbic Acid; Humans; Injections, Intravenous; Pyridoxine; Thiamine; Tuberculosis, Pulmonary

Topics: Ascorbic Acid; Aspirin; Asthma; Calcium; Citrates; Coronary Disease; Depression, Chemical; Diabetes Mellitus; Duodenal Ulcer; Dwarfism, Pituitary; Emphysema; Facial Paralysis; Gluconates; Histamine H1 Antagonists; Humans; Hypertension; Hyperthyroidism; Kidney Calculi; Liver Diseases, Parasitic; Magnesium; Oxalates; Phosphates; Pyridoxine; Schistosomiasis; Stimulation, Chemical; Terpenes; Tuberculosis, Pulmonary

Topics: Adenosine Triphosphate; Adolescent; Adrenocorticotropic Hormone; Adult; Antitubercular Agents; Ascorbic Acid; Drug Resistance, Microbial; Ethionamide; Female; Heparin; Humans; Injections, Intravenous; Isoniazid; Male; Methods; Middle Aged; Mycobacterium; Pyridoxine; Streptomycin; Thiamine; Tuberculosis, Pulmonary; Vitamin B 12

Topics: Aminosalicylic Acids; Ascorbic Acid; Bone Conduction; Dihydrostreptomycin Sulfate; Drug Hypersensitivity; Hearing; Humans; Kanamycin; Pantothenic Acid; Streptomycin; Sulfates; Tuberculosis, Pulmonary; Viomycin

Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Adult; Ascorbic Acid; Chronic Disease; Female; Humans; Injections, Intravenous; Isoniazid; Male; Middle Aged; Pyridoxine; Streptomycin; Thiamine; Tuberculosis, Pulmonary; Vitamin B 12; Vitamins

Topics: Anti-Bacterial Agents; Antitubercular Agents; Ascorbic Acid; Bacteria; Cholera; Dapsone; Dysentery, Bacillary; Female; Heterocyclic Compounds; Humans; Leprosy; Meningitis; Meningitis, Haemophilus; Methods; Otorhinolaryngologic Diseases; Pregnancy; Puerperal Infection; Scarlet Fever; Sulfathiazoles; Sulfones; Tuberculosis, Meningeal; Tuberculosis, Pulmonary; Urinary Tract Infections; Vitamin K

Topics: Adult; Anti-Inflammatory Agents; Ascorbic Acid; Dyspepsia; Gastrointestinal Diseases; Humans; Iron; Male; Middle Aged; Peptic Ulcer; Tuberculosis, Pulmonary

Topics: Ascorbic Acid; Blood; Child, Preschool; Diphtheria; Hepatitis A; Humans; Measles; Tuberculosis, Pulmonary; Urine; Whooping Cough

Topics: Animals; Ascorbic Acid; Connective Tissue; Humans; Lung; Rabbits; Tuberculosis; Tuberculosis, Pulmonary

Topics: Ascorbic Acid; Biomedical Research; Hemorrhage; Humans; Promethazine; Rutin; Tuberculosis; Tuberculosis, Pulmonary

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ascorbic Acid; Skin Diseases; Tuberculosis; Tuberculosis, Pulmonary

Topics: Ascorbic Acid; Carbohydrate Metabolism; Humans; Tuberculosis; Tuberculosis, Pulmonary; Vitamins

Topics: Ascorbic Acid; Blood Vessels; Flavonoids; Humans; Ketones; Lung; Tuberculosis; Tuberculosis, Pulmonary; Vitamins

Topics: Ascorbic Acid; beta Carotene; Carotenoids; Humans; Plasma; Research; Tuberculosis; Tuberculosis, Pulmonary; Vitamin A; Vitamin K; Vitamins

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ascorbic Acid; Humans; Tuberculosis; Tuberculosis, Pulmonary; Vitamins

Topics: Antioxidants; Ascorbic Acid; Humans; Tuberculosis; Tuberculosis, Pulmonary; Vitamins

Topics: Ascorbic Acid; Carbohydrate Metabolism; Humans; Tuberculin; Tuberculosis; Tuberculosis, Pulmonary

Topics: Ascorbic Acid; Carbohydrate Metabolism; Humans; Tuberculosis; Tuberculosis, Pulmonary

Topics: 17-Ketosteroids; Ascorbic Acid; Humans; Steroids; Tuberculosis; Tuberculosis, Pulmonary; Urine; Vitamins

Topics: Aminosalicylic Acid; Anti-Bacterial Agents; Ascorbic Acid; Communicable Diseases; Tuberculosis; Tuberculosis, Pulmonary; Vitamins

Topics: Aminosalicylic Acid; Anti-Bacterial Agents; Ascorbic Acid; Gastrointestinal Diseases; Tuberculosis; Tuberculosis, Pulmonary; Vitamins

Topics: Anti-Bacterial Agents; Ascorbic Acid; Calcium; Calcium, Dietary; Tuberculosis; Tuberculosis, Pulmonary; Vitamins

Topics: Ascorbic Acid; Humans; Nutritional Status; Tuberculosis; Tuberculosis, Pulmonary; Vitamin A

Topics: Ascorbic Acid; Humans; Tuberculosis; Tuberculosis, Pulmonary

Topics: Ascorbic Acid; Calcium; Calcium, Dietary; Humans; Tuberculosis; Tuberculosis, Pulmonary

Topics: Aerosols; Ascorbic Acid; Humans; Respiratory Therapy; Tuberculosis; Tuberculosis, Pulmonary

Topics: Ascorbic Acid; Humans; Tuberculosis; Tuberculosis, Pulmonary; Vitamins