| Excerpt | Reference |
|---|
| "The event of bleeding is the main factor that elevates total peripheral resistance and reduces tissue perfusion with consequent lowering of oxygen consumption and alkalosis secondary to impaired carbon dioxide production; when bleeding ceases these changes partially reverse in a manner characteristic of that induced by the reinfusion of shed blood; and hypovolaemia per se has a relatively weak influence." | ( Dudley, HA; Pardy, BJ, 1979) |
| "Bleeding is the major source of morbidity and mortality of tonsillectomy and most operative time is spent securing haemostasis." | ( Kerr, AI; Riad, M; Rogers, MJ; Sharp, JF, 1991) |
| "Bleeding is reduced dramatically by this technique." | ( De Mey, A; Govaerts, MJ; Widera, I, 1985) |
| "We conclude that bleeding is related to the anticoagulant effects of fibrinogen degradation products interacting with heparin, and may be largely independent of hypofibrinogenemia." | ( Gangadharan, V; Gordon, S; Hauser, AM; Mammen, EF; Ramos, RG; Stewart, JR; Timmis, GC; Westveer, DC, 1986) |
| "Bleeding is a common complication in patients suffering from multiple myeloma." | ( Egbring, R; Havemann, K; Klingemann, HG, 1981) |
| "Bleeding is relatively frequent during acenocoumarol therapy, mainly in patients with worse control, but only in a few of these episodes is severe, and is usually associated with local lesions." | ( Escolar, G; Maragall, S; Monteagudo, J; Ordinas, A; Reverter, JC; Tàssies, D, 1995) |
| "Anemia and bleeding are commonly observed in patients with multiple myeloma (MM)." | ( Aoki, S; Shibata, A, 1995) |
| "The risk of serious bleeding is probably acceptable if low dosages are used." | ( Meade, TW; Miller, GJ, 1995) |
| "Postoperative bleeding is caused by alterations in the normal process of hemostasis or by a surgical problem." | ( Brown, MM; Kemper, KM, 1993) |
| "If excessive bleeding is noted in a patient with a normal TEG, this suggests a surgically correctable etiology." | ( Essell, JH; Martin, TJ; Salinas, J; Smith, VC; Thompson, JM, 1993) |
| "Bleeding is the most serious complication of the use of oral anticoagulation in the prevention and treatment of thromoboembolic complications." | ( Berrettini, M; Ciavarella, N; Coccheri, S; D'Angelo, A; Devoto, G; Erba, N; Leali, N; Manotti, C; Moia, M; Musolesi, S; Palareti, G; Pengo, V; Poggi, M, 1996) |
| "Major bleeding is rare and seem to be related to higher platelet counts: therefore, a platelet count over 1500 x 10(9)/L is generally regarded as an indication for cytoreduction." | ( Barbui, T; Brière, J; Dupuy, E; Finazzi, G; Kiladjian, JJ, 1996) |
| "Intratumoural bleeding is found in varying percentages, between 9." | ( Barrena, R; Cacicedo, Y; García-Asensio, S; Guedea, A; Guelbenzu, S; Mota, J, 1996) |
| "Minor bleedings are most commonly managed by temporarily discontinuing treatment and by giving vitamin K to antagonize the coumarin derivative effects." | ( Heinrich, W; Krischek, B; Mörsdorf, S; Pindur, G; Schenk, JF; Wenzel, E, 1999) |
| "The risk of bleeding is higher in the introductory phase of anticoagulant treatment than later on." | ( Antonsen, S; Hansen, KF; Husted, SE; Jespersen, J; Lassen, JF; Nielsen, HK; Nielsen, JD, 2000) |
| "The nature of bleeding is instructive with respect to preliminary categorization." | ( Teitel, JM, 2000) |
| "Abnormal uterine bleeding is the most common complication of IUD use." | ( Adam-steen, C; Desmons, F, 1985) |
| "Major bleeding is rare and seems to be related to higher platelet counts." | ( Barbui, T; Finazzi, G, 2003) |
| "Although most bleeding is not life threatening, it does cause short-term morbidity and inconvenience to patients, as well as possibly diminishing their quality of life to some degree." | ( Beyth, RJ, 2002) |
| "Abnormal uterine bleeding is the major reason for discontinuing long-term progesterone-only contraceptives (LTPOCs)." | ( Critchley, H; Dubon, P; Kadner, S; Krikun, G; Kumar, P; Lockwood, CJ; Schatz, F, 2004) |
| "Although major bleeding is relatively uncommon, the incidence of intracranial haemorrhage is higher during the first few days of life than at any other stage in childhood, which relates to the trauma of delivery." | ( Chalmers, EA, 2004) |
| "Bleeding is the major complication of anticoagulant therapy." | ( Beyth, RJ; Kearon, C; Levine, MN; Raskob, G; Schulman, S, 2004) |
| "Bleeding is described in the pathology texts as being a consequence of the vascular architecture of the myxopapillary subtype and so postulated to be more common in this group." | ( Bavetta, S; Chelvarajah, R; Garvan, N; Tait, MJ, 2004) |
| "Bleeding is the major complication of anticoagulant treatment, and the relative risks for bleeding vs stroke must be considered when starting anticoagulation." | ( Corley, SD; DiMarco, JP; Flaker, G; Greene, HL; Mitrani, G; Nemeth, M; Rosenfeld, LE; Safford, RE; Waldo, AL, 2005) |
| "Bleeding is a significant problem that complicates management of patients with AF." | ( Corley, SD; DiMarco, JP; Flaker, G; Greene, HL; Mitrani, G; Nemeth, M; Rosenfeld, LE; Safford, RE; Waldo, AL, 2005) |
| "Intra-articular bleeding is the most common clinical manifestation of hemophilia, and can adversely affect joints and lead to arthropathy." | ( Hoots, WK, 2006) |
| "Bleeding is the adverse effect feared by physicians that most limits the use of VKAs in older frail patients." | ( Debray, M; Gaussem, P; Gouin-Thibault, I; Pautas, E; Siguret, V, 2006) |
| "Bleeding is probably the major complication of anticoagulant treatment with vitamin K antagonists represented nowadays mostly by warfarin in the Czech Republic." | ( Blatný, J; Brejcha, M; Gumulec, J; Kessler, P; Klaricová, K; Klodová, D; Králová, S; Lasota, Z; Penka, M; Riedlová, P; Sumná, E; Wróbel, M, 2006) |
| "Intracystic slow bleeding is very difficult to diagnose using conventional sonography; consequently, a new sonographic technique has been sought." | ( Fujimori, S; Funaoka, M; Furukawa, K; Ishida, H; Komatsuda, T; Naganuma, H; Niwa, M; Yamada, M, 2006) |
| "If the risk of bleeding is high, then modification of antiplatelet medications should be considered on a case-by-case basis." | ( D'Souza, S; Dalal, AR; Shulman, MS, 2006) |
| "Coagulopathic bleeding is multifactorial, including dilution and consumption of both platelets and coagulation factors, as well as dysfunction of the coagulation system." | ( Grottke, O; Henzler, D; Rossaint, R; Spahn, DR, 2007) |
| "Bleeding is a frequent complication in FA, leading to substantial morbidity and mortality." | ( Ebell, W; Grossmann, R; Hanenberg, H; Holzhauer, S; Schindler, D; Sitaru, AG; Walter, U; Wirbelauer, J, 2007) |
| "However, bleeding is rare in this syndrome." | ( Abdallah, TB; Beji, S; El Younsi, F; Ezzine, S; Guermazi, S; Hamida, FB; Kaaroud, H; Kheder, A; Moussa, FB, 2008) |
| "Bleeding is the major complication of anticoagulant and fibrinolytic therapy." | ( Beyth, RJ; Kearon, C; Levine, MN; Schulman, S, 2008) |
| "Bleeding is the most common complication of anticoagulant therapy." | ( Crowther, M, 2008) |
| "Bleeding is associated with adverse outcome in acute coronary syndromes." | ( DeYoung, P; Fitchett, DH; Goodman, SG; Huynh, T; Langer, A; Weeks, A; Yan, AT; Yan, RT, 2008) |
| "Bleeding is a powerful independent predictor of poor long-term outcome, even after adjusting for other associated prognostic factors such as advanced age and renal dysfunction." | ( DeYoung, P; Fitchett, DH; Goodman, SG; Huynh, T; Langer, A; Weeks, A; Yan, AT; Yan, RT, 2008) |
| "Easy bruising and bleeding are prominent features of some heritable disorders of connective tissue (HDCT), resulting from fragility of capillaries and the perivascular connective tissue rather than clotting or platelet dysfunction." | ( De Paepe, A; Malfait, F, 2009) |
| "Risk factors for bleeding are the intensity of anticoagulation, the management strategy to keep the INR in the desired range, and patient characteristics." | ( Levi, M, 2009) |
| "Bleeding is the most important complication of VKAs and a major concern for both physicians and patients." | ( Cosmi, B; Palareti, G, 2009) |
| "Bleeding is a serious adverse drug reaction associated with warfarin therapy, often induced by interacting co-medication." | ( Hauta-Aho, M; Laine, K; Tirkkonen, T; Vahlberg, T, 2009) |
| "The risk of bleeding is influenced by the intensity, variability and duration of anticoagulation, patient age, presence of co-morbidities and concomitant drug therapy." | ( Maclean, R; Makris, M; van Veen, JJ, 2010) |
| "Bleeding is a strong predictor of death in patients hospitalized for arterial thrombosis who are treated with antithrombotic therapy, but the prognostic importance of bleeding in patients receiving antithrombotic prophylaxis for venous thromboembolism is uncertain." | ( Eikelboom, JW; O'Donnell, M; Quinlan, DJ, 2009) |
| "Risk of a relevant bleeding is higher with rivaroxaban than with enoxaparin and the same tendency exists also vs dabigatran." | ( Kolundzic, R; Trkulja, V, 2010) |
| "Nuisance bleeding is common in patients on prolonged DAPT post-DES implantation and can impact compliance." | ( Ben-Dor, I; Collins, SD; Delhaye, C; Gaglia, MA; Gonzalez, MA; Kaneshige, K; Kent, KM; Li, Y; Maluenda, G; Pichard, AD; Satler, LF; Scheinowitz, M; Suddath, WO; Syed, AI; Torguson, R; Wakabayashi, K; Waksman, R; Xue, Z, 2010) |
| "Anemia and major bleeding are independent predictors of outcomes after acute coronary syndromes and percutaneous coronary intervention (PCI)." | ( Bagur, R; Bertrand, OF; Costerousse, O; De Larochellière, R; Déry, JP; Gleeton, O; Larose, E; Nguyen, CM; Poirier, P; Proulx, G; Rinfret, S; Rodés-Cabau, J; Roy, L, 2010) |
| "Irregular bleeding is often cited as the reason for discontinuation of depot-medroxyprogesterone acetate (DMPA) after the first injection." | ( Dempsey, A; Roca, C; Westhoff, C, 2010) |
| "Fear of bleeding is the most often cited reason." | ( Garcia, DA; Hylek, EM; Lopes, RD, 2010) |
| "Major bleeding is common, though a great degree of the variability in the rate of bleeding is largely based on differences in baseline characteristics, comorbidities, and invasive treatment strategies, rather than specific anticoagulant regimens." | ( Alexander, KP; Cannon, CP; Chen, AY; Desai, NR; Foody, JM; Kadakia, MB; Scirica, BM; Wiviott, SD, 2010) |
| "Bleeding is independently associated with 30-day and 1-year mortality." | ( Dambrink, JH; Dill, T; Hamm, C; Hermanides, RS; Kolkman, E; Ottervanger, JP; Ten Berg, JM; van 't Hof, AW; van Houwelingen, G, 2012) |
| "The risk of bleeding is a well-known complication in patients on hemodialysis (HD)." | ( Jelicic, I; Kovacic, V; Ljutic, D; Radic, J; Sain, M, 2011) |
| "Uncontrolled bleeding is an important cause of death in trauma victims." | ( Coats, T; Ker, K; Roberts, I; Shakur, H, 2011) |
| "Excessive fetal bleeding is most frequently reported and often associated with an underlying coagulopathy in the neonate." | ( Becker, JH; Brouwers, HA; Evers, A; Kwee, A; Moormann, KA; Schaap, TP; Schuitemaker, NW; Visser, GH; Westerhuis, ME, 2011) |
| "Bleeding is potentially the most significant antiplatelet-associated side effect." | ( Guthrie, R, 2011) |
| "Risk factors for bleeding are the intensity of anticoagulation, the management strategy to keep the anticoagulant effect in the desired range, and patient characteristics." | ( Eerenberg, ES; Kampuisen, PW; Levi, M, 2011) |
| "Serious bleeding is a frequent and feared treatment complication." | ( Boman, K; Jansson, JH; Järvholm, LS; Johansson, L; Lind, M; Nilsson, TK, 2012) |
| "Bleeding is the most important complication of VKAs and a major concern for both physicians and patients, limiting a more widespread prescription of the treatment." | ( Palareti, G, 2011) |
| "Inapparent bleeding is difficult to diagnose and is recognized from the dynamics of blood losses." | ( Landor, I; Novotný, K; Pádr, R; Sosna, A, 2011) |
| "Bleeding is the major complication associated with warfarin therapy." | ( Bishop, JR; Cavallari, LH; Cochran, KA; Shapiro, NL, 2011) |
| "Bleeding is a major complication of warfarin therapy." | ( Biskupiak, J; Brixner, DI; Ghate, SR; Kwong, WJ; Ye, X, 2011) |
| "Bleeding is the leading cause of death for patients with acute promyelocytic leukemia (APL)." | ( Chang, H; Dunn, P; Hung, YS; Kuo, MC; Lin, TL; Shih, LY; Tang, TC; Wang, PN; Wu, JH, 2012) |
| "High risk of bleeding is immediately evident with TT after myocardial infarction/percutaneous coronary intervention in patients with atrial fibrillation." | ( Gislason, GH; Hansen, CM; Hansen, ML; Karasoy, D; Kristensen, SL; Køber, L; Lamberts, M; Olesen, JB; Ruwald, MH; Torp-Pedersen, C, 2012) |
| "Bleeding is the most common and serious adverse effect of currently available antiplatelet drugs." | ( Bae, ON; Chung, JH; Chung, KY; Kang, S; Kim, K; Lim, KM; Noh, JY, 2012) |
| "Bleeding is a common complication of proctitis secondary to radiotherapy of pelvic tumours." | ( Borda, N; Elósegui, JL; Enriquez Navascués, JM; Lizarazu, A; Placer, C, 2013) |
| "Major bleeding is a serious and potentially fatal complication of treatment with vitamin K antagonists (VKAs)." | ( Ageno, W; Benedetti, R; Condoleo, E; Dentali, F; Gallerani, M; Imberti, D; Magnacavallo, A, 2013) |
| "Bleeding is the main complication of oral anticoagulants, anti-vitamin K or new drugs such as anti-factor Xa or anti-thrombin agents." | ( Korin, J, 2012) |
| "Identifying major bleeding is fundamental to assessing the outcomes of anticoagulation therapy." | ( Ash, AS; Berlowitz, DR; Hylek, EM; Jasuja, GK; Miller, DR; Ozonoff, A; Reisman, JI; Rose, AJ; Zhao, S, 2013) |
| "Uncontrolled bleeding is an important cause of death in trauma victims." | ( Coats, T; Ker, K; Roberts, I; Shakur, H, 2012) |
| "If bleeding is life/limb threatening, consider an additional haemostatic agent." | ( Alikhan, R; Baglin, T; Benson, G; Green, L; Keeling, D; Marshall, S; Patel, R; Pavord, S; Rayment, R; Rose, P; Tait, C, 2014) |
| "Bleeding is of particular clinical importance in the management of chronic immune thrombocytopenia (ITP), which involves impaired platelet production and accelerated destruction." | ( Brainsky, A; Fogarty, P; Mayer, B; Tarantino, MD; Vasey, SY, 2013) |
| "Bleeding is a major limitation of antithrombotic therapy among invasively managed non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients; therefore, we examined the use of radial access and its association with outcomes among NSTE-ACS patients." | ( Armstrong, PW; Dalby, A; Gibson, CM; Giugliano, RP; Harrington, RA; Klutstein, MW; Lewis, BS; Lutchmedial, S; Newby, LK; Rao, SV; Steg, PG; Van de Werf, F; Westerhout, CM; Widimsky, P; Zeymer, U, 2013) |
| "Bleeding is the main complication of warfarin therapy, even patients with an international normalized ratio (INR) in the target range can suffer bleeding, suggesting that INR does not perfectly reflect the therapeutic effect of warfarin." | ( Chatard, B; Dargaud, Y; Genty, A; Hoffman, M; Lefrapper, L; Lin, FC; Marin, S; Monroe, DM; Négrier, C, 2013) |
| "Bleeding is assumed to be the cause of painful joints or muscles." | ( Ceponis, A; Glass, CS; von Drygalski, A; Wong-Sefidan, I, 2013) |
| "The risk of major bleeding is increased with antiplatelet therapy." | ( Little, SH; Massel, DR, 2013) |
| "Bleeding is the most common complication observed after prostate biopsy, but the use of aspirin or nonsteroidal anti-inflammatory drugs is not an absolute contraindication to prostate biopsy." | ( Anastasiadis, A; Antoniewicz, A; Cordeiro, E; De Reijke, T; Dimitriadis, G; Zapała, L, 2013) |
| "Postcircumcision bleeding is particularly concerning where most infants are breastfed, and thus these infants are at increased risk of vitamin K deficiency bleeding." | ( Data, S; Plank, RM; Shearer, MJ; Sokal, DC; Steinmetz, T, 2013) |
| "Bleeding is a common, noncardiac, preventable complication of percutaneous coronary intervention." | ( Baklanov, DV; Kim, S; Marso, SP; Rao, SV; Subherwal, S, 2013) |
| "But when bleeding is not life-threatening, the thrombotic risk is too poorly documented to justify exposing patients to a plausible and inadequately evaluated risk." | ( , 2013) |
| "Post-PCI bleeding is an important prognostic factor in patients >75 years of age." | ( Byrne, RA; Cassese, S; Fusaro, M; Kastrati, A; Laugwitz, KL; Ndrepepa, G; Neumann, FJ; Richardt, G; Schulz, S, 2014) |
| "Bleeding is a serious complication of the use of oral anticoagulants, and limited information is available to guide the reversal of warfarin or TSOAs in patients who are bleeding or are in need of an urgent invasive procedure." | ( Cipolle, MD; Dager, WE; Kalus, JS; Lewin, JJ; Nutescu, EA, 2013) |
| "'Haircut-associated bleeding' is a newly recognized entity that affects at least a quarter of African men who wear shiny clean-shave ('chiskop') haircuts." | ( Davids, LM; Hardie, D; Hu, N; Khumalo, NP; Korsman, S; Mkentane, K; Mthebe, T; Muthukarapan, C; Rousseau, J, 2013) |
| "Bleeding is the most frequent cause of preventable death after severe injury." | ( Eckert, M; Izenberg, S; Martin, MJ; McVay, D; Nelson, D; Porta, CR; Salgar, S, 2013) |
| "Uncontrolled bleeding is the main preventable cause of death in severe trauma patients." | ( Aubron, C; Cooper, DJ; Fraser, JF; Reade, MC, 2014) |
| "Bleeding is a major problem in warfarin pretreated patients who need emergency surgical procedures." | ( Cavuş, UY; Civelek, C; Dur, A; Gülen, B; Ipek, G; Karayel, E; Sönmez, E; Uysal, O, 2014) |
| "Risk factors for bleeding are typically the same for old and new anticoagulants." | ( Schulman, S; Suryanarayan, D, 2014) |
| "Bleeding is a common and feared complication of oral anticoagulant therapy." | ( Ageno, W; Bellesini, M; Bonfanti, C; Borretta, V; Brondi, B; Dentali, F; Di Minno, MN; Fantoni, C; Franchini, M; Lupoli, R; Mumoli, N; Pomero, F; Riva, N, 2014) |
| "Bleeding is one of the serious adverse events of bevacizumab (BV)." | ( Ishizuna, K; Kawashima, M; Kojima, M; Ninomiya, J; Nozaki, M; Ogawa, T; Ueda, Y; Yamagishi, H, 2014) |
| "Intrahepatic bleeding is exceptional and only very few cases have been described." | ( Bonsignore, A; De Stefano, F; Palmiere, C; Pizzorno, E; Ventura, F, 2014) |
| "Major bleeding is associated with high subsequent mortality in ACS." | ( Becker, RC; Cannon, CP; Ducrocq, G; Harrington, RA; Held, C; Himmelmann, A; Lassila, R; Schulte, PJ; Sorbets, E; Steg, PG; Storey, RF; Wallentin, L, 2015) |
| "Bleeding is an important source of morbidity in patients with a left ventricular assist device." | ( Acker, MA; Atluri, P; Bartoli, CR; Restle, DJ; Zhang, DM, 2015) |
| "Bleeding is the second leading cause of death after trauma." | ( Paterson, TA; Stein, DM, 2014) |
| "Bleeding is a major concern in treatment of atrial fibrillation (AF) with vitamin K antagonist (VKA)." | ( Joung, B; Kim, JY; Lee, MH; Lee, SJ; Pak, HN; Uhm, JS, 2015) |
| "Overall, bleeding is rare in apheresis." | ( Biesenbach, P; Derfler, K; Druml, W; Pablik, E; Rees, A; Zöllner, S, 2014) |
| "Minor bleeding is 3." | ( Broncel, M; Ciastkowska, A; Duraj, I; Gorzelak-Pabiś, P; Szlagowska, L, 2014) |
| "Gastric bleeding is one of the irritant problems in ulcer patients." | ( Bang, BW; Kim, MK; Lee, DH; Maeng, JH; Yang, SG, 2015) |
| "Excessive bleeding is a risk associated with cardiac surgery." | ( Drake, L; Faulke, D; Fraser, JF; Fung, YL; Pearse, BL; Rapchuk, IL; Ryan, EG; Smith, I; Tesar, P; Wall, D; Ziegenfuss, M, 2015) |
| "Since bleeding is the most common and most dangerous side effect of long-term anticoagulation, and because NOACs have very different mechanisms of action and pharmacokinetics compared with VKA, physicians are naturally concerned about the lack of experience regarding frequency, management and outcome of NOAC-associated bleeding in daily care." | ( Beyer-Westendorf, J; Breslin, T; NiAinle, F; Werth, S, 2015) |
| "Uncontrolled bleeding is an important cause of death in trauma victims." | ( Coats, TJ; Ker, K; Roberts, I; Shakur, H, 2015) |
| "Bleeding is the most common preventable cause of death in trauma patients." | ( Etxaniz, A; Pita, E, 2016) |
| "Bleeding is the main complication on vitamin K antagonist treatment (VKA), particularly in elderly patients." | ( Bosson, JL; Chidlovskii, E; Couturier, P; Gaboreau, Y; Lebelhomme, A; Pernod, G; Soave, C, 2015) |
| "Bleeding is an adverse event in patients taking anticoagulants." | ( Ciccone, MM; Devito, F; Maiello, M; Palmiero, P; Zito, A, 2018) |
| "Bleeding is a complication of treatment with factor Xa inhibitors, but there are no specific agents for the reversal of the effects of these drugs." | ( Bronson, MD; Castillo, J; Conley, PB; Connolly, SJ; Crowther, MA; Curnutte, JT; Gold, A; Leeds, JM; Lu, G; Mar, FA; Mathur, VS; Siegal, DM; Wiens, BL, 2015) |
| "Bleeding is the main adverse effect of antiplatelet therapy and is potentially life threatening." | ( Algra, A; Greving, JP; Hilkens, NA, 2016) |
| "Bleeding is the most important adverse effect of antithrombotic treatment and may be a major cause of morbidity, longstanding debilitation, and even mortality." | ( Levi, M, 2015) |
| "The risk for major bleeding is less for NOAC than for VKA, with a particular superiority concerning the avoidance of intracerebral hemorrhage." | ( Hohnloser, SH, 2016) |
| "While bleeding is a well-known complication of warfarin use and is thought to be a contributory cause of treatment discontinuation, studies quantifying this association are limited." | ( Azoulay, L; Huang, HY; Kawabata, H; Pan, X; Simon, TA, 2016) |
| "Perioperative bleeding is a potential complication of robot-assisted laparoscopic radical prostatectomy (RALP) that may worsen outcomes." | ( Bianchi, G; De Carne, C; Fidanza, F; Ghaith, A; Martorana, E; Micali, S; Pirola, GM, 2016) |
| "Moderate bleeding is suggested to be managed by a primarily conservative approach." | ( Kaufner, L; Rosenthal, C; Sander, M; von Heymann, C, 2016) |
| "Bleedings are the most important side effects of anticoagulants." | ( Boda, Z, 2016) |
| "Essentials Minor bleeding is associated with subsequent major bleeding in patients treated with vitamin K antagonists." | ( Cannegieter, SC; le Cessie, S; Lijfering, WM; Reitsma, PH; van der Meer, FJ; van Rein, N; van Vliet, IP, 2016) |
| "Bleeding is associated with the depletion of fibrinogen, thus increasing the risk of coagulopathy, further bleeding and transfusion requirements." | ( Afshari, A; Jensen, NH; Stensballe, J, 2016) |
| "Bleeding is a feared complication of anticoagulants." | ( Grove, EL; Hvas, AM; Larsen, FU, 2016) |
| "Perioperative bleeding is a potentially devastating complication in neurosurgical patients, and plasma fibrinogen concentration has been identified as a potential modifiable risk factor for perioperative bleeding." | ( Applegate, R; Bull, BS; Gren, EC; Hay, KL; Hayes, WK; Kelln, W; Kim, CH; Lekic, T; McBride, DW; Raval, R; Sherchan, P; Tang, J; Zhang, JH, 2017) |
| "Consequential bleeding is a concern with all anticoagulants." | ( Banares, L; Dager, WE, 2017) |
| "Bleeding is the most common complication after renal biopsy." | ( Inoue, T; Kitagawa, M; Mise, K; Morinaga, H; Ogawa-Akiyama, A; Onishi, A; Sugiyama, H; Tanaka, K; Uchida, HA; Wada, J; Yamanari, T, 2017) |
| "Reflex bleeding is an effective defensive mechanism against predators." | ( Billen, J; Dejean, A; Orivel, J; Petitclerc, F; Roux, O; Vantaux, A, 2017) |
| "Bleeding is a leading cause of death among trauma patients." | ( Abdelhamid, B; Dayem, OAE; Fawzy, M; Gamal, M; Hasanin, A; Rady, A; Zakaria, D, 2018) |
| "Essentials Bleeding is a common cause of hospital admission and readmission in oral anticoagulant users." | ( Chan, EW; Lau, WCY; Leung, WK; Li, X; Lip, GYH; Man, KKC; Siu, CW; Wong, ICK, 2017) |
| "Warfarin-related bleeding is among the most common cause of hospital admissions as a result of adverse drug events." | ( Chan, EW; Lau, WCY; Leung, WK; Li, X; Lip, GYH; Man, KKC; Siu, CW; Wong, ICK, 2017) |
| "Detecting active bleeding is critical." | ( Isomoto, H; Koda, M; Matono, T; Miyoshi, K; Okamoto, T; Sugihara, T, 2018) |
| "Uncontrolled bleeding is the leading preventable cause of death in patients with multiple injuries." | ( Caspers, M; Maegele, M; Schöchl, H, 2017) |
| "However, bleeding is still a severe drug adverse reaction of ticagrelor therapy." | ( Cui, M; Gu, Z; Liu, X; Shen, L; Zhang, C, 2017) |
| "Mucosal bleeding is a frequent sequelae of thrombocytopenia, which is typically managed with platelet transfusion." | ( Cohn, CS; Gniadek, TJ; Pulkrabek, S, 2017) |
| "Persistent bleeding is a common reason for admitting patients with advanced cancer to a palliative care unit." | ( Bardenheuer, HJ; Frankenhauser, S; Geist, MJP; Kessler, J, 2017) |
| "Bleeding is one of the possible adverse events during clopidogrel therapy." | ( Antonijevic, N; Kusic-Tisma, J; Matic, D; Novkovic, M; Radojkovic, D; Rakicevic, L, 2018) |
| "Major bleeding is managed using a VKA reversal strategy." | ( Lapostolle, F; Martin, AC; Pailleret, C; Siguret, V; Tazarourte, K; Vigué, B; Zerbib, Y, 2018) |
| "Overall, AF and bleeding are manageable clinical events in patients receiving IB, not requiring drug interruption in most cases." | ( Boriani, G; Corradini, P; Cuneo, A; Falanga, A; Foà, R; Gaidano, G; Ghia, PP; Marasca, R; Martelli, M; Massaia, M; Mauro, FR; Minotti, G; Molica, S; Montillo, M; Pinto, A; Tedeschi, A; Vitolo, U; Zinzani, PL, 2018) |
| "Epistaxis, or nasal bleeding, is a common complication after nasotracheal intubation (NTI)." | ( Tong, JL; Tung, A, 2018) |
| "The risk of bleeding is a major concern when oral anticoagulation is required to prevent stroke, and concomitant therapy with antiplatelet agents is required to minimize recurrent ischemic events." | ( Alexander, JH; Darius, H; Goodman, SG; Granger, CB; Liaw, D; Lopes, RD; Mehran, R; Vora, AN; Windecker, S, 2018) |
| ": Bleeding is the main complication of anticoagulant treatments as dabigatran etexilate." | ( Barbay, V; Billoir, P; Boyer, D; Chrétien, MH; Fresel, M; Girault, C; Grangé, S; Le Cam Duchez, V, 2018) |
| "Bleeding is the main complication of long-term anticoagulant use." | ( Almeida, R; Antunes, I; Ferreira, V; Freixo, C; Gonçalves, J; Martins, J; Mendes, D; Teixeira, G; Veiga, C, 2019) |
| "SUMMARY: Background Bleeding is a serious complication of neonates undergoing cardiopulmonary bypass (CPB) and associated with substantial morbidity and mortality." | ( Brown, AC; Guzzetta, NA; Nellenbach, K, 2018) |
| "However, bleeding is enhanced in tirofiban treated patients." | ( Dannenberg, L; Helten, C; Hohlfeld, T; Kelm, M; Levkau, B; Mourikis, P; Naguib, D; Pöhl, M; Polzin, A; Schulze, V; Wolff, G; Zako, S; Zeus, T, 2019) |
| "Bleeding is a common complication in patients taking warfarin." | ( Martins, MAP; Nobre, V; Oliveira, JAQ; Pinho Ribeiro, AL; Ribeiro, DD; Rocha, MODC, 2018) |
| "However, bleeding is a major side effect of anticoagulant therapy in VTE patients." | ( Ebato, M; Higashino, M; Hozumi, T; Kogo, M; Matsui, M; Nakamura, S; Sasaki, T; Shimizu, T; Sunaga, T; Suzuki, H; Takahashi, N; Watanabe, T, 2019) |
| "Bleeding is an inevitable and often severe complication after endoscopic sphincterotomy (EST)." | ( Akimoto, Y; Fujii, M; Harada, R; Hirao, K; Ishida, E; Kato, H; Miyaike, J; Muro, S; Nishimura, M; Okada, H; Seki, H; Takatani, M; Toyokawa, T; Tsugeno, H; Ueki, T; Wato, M; Yunoki, N, 2020) |
| "Intra-alveolar bleeding is a rare and severe medical emergency due to numerous causes." | ( Azzouzi, L; Chibane, S; Drighil, A; Habbal, R; Loutfi, A, 2019) |
| "Bleeding is an important cause of death in trauma victims." | ( Benedetti, G; Edema, N; Jachetti, A; Massénat, RB; Trelles, M; Van Den Bergh, R; Woolley, SC, 2019) |
| "Uncontrollable bleeding is still a worldwide killer." | ( Li, QY; Li, Y; Ling, QL; Ruan, KH; So, SP, 2019) |
| "Bleeding is a major adverse effect of veno-venous extracorporeal membrane oxygenation (vvECMO) therapy in surgical patients." | ( Graf, B; Gruber, M; Holzer, F; Lunz, D; Philipp, A; Redel, A, 2020) |
| "Although bleeding is the most common complication of anticoagulants, only a few studies have addressed the safety of direct oral anticoagulants in East Asian patients." | ( Furukawa, Y; Hashida, T; Ikesue, H; Kinoshita, M; Kitai, T; Muroi, N; Nakagawa, H; Takase, T, 2020) |
| "Abnormal bleeding is sometimes observed in patients with immunoglobulin light chain (AL) amyloidosis." | ( Arahata, M; Asakura, H; Ichinose, A; Kadohira, Y; Morishita, E; Takamatsu, H; Yamada, S, 2020) |
| "Bleeding is the most concerning complication associated with anticoagulant therapy but poorly characterized and important for risk/benefit assessment." | ( Cohen, AT; Katholing, A; Martinez, C; Wallenhorst, C, 2020) |
| "Bleeding is a frequently encountered complication in patients undergoing percutaneous coronary intervention (PCI) treated with a dual antiplatelet therapy regimen with aspirin plus an oral inhibitor of the P2Y12 platelet receptor (clopidogrel, prasugrel, ticagrelor) or with the combination of antiplatelet drugs and an anticoagulant in patients who have a specific indication for chronic anticoagulation therapy such as atrial fibrillation." | ( Capodanno, D; Capranzano, P; Francaviglia, B; Tamburino, C, 2020) |
| "Patients with major bleeding are commonly admitted to the ICU." | ( Bagshaw, SM; Carrier, M; Castellucci, LA; Dowlatshahi, D; Fergusson, DA; Fernando, SM; Kyeremanteng, K; McIsaac, DI; Mok, G; Rochwerg, B; Tanuseputro, P; Wells, PS, 2020) |
| "Bleeding is one of the most important causes of mortality in patients with acute coronary syndrome (ACS)." | ( Acar, B; Akçay, FA; Akgün, DE; Altındag, R; Avci, E; Celik, A; Demirtas, AO; Ergene, AO; Güzel, T; Kiriş, T; Kurmuş, Ö; Öztürk, Ö; Safak, Ö; Yildirim, T; Yüksek, U, 2020) |
| "Uncontrolled bleeding is thought to be the most deadly cause of pre-hospital, traffic, and military accidents death." | ( Gong, M; Liu, C; Liu, X; Qiao, W; Shafiq, F; Song, Q; Sun, G; Wang, L, 2021) |
| "Delayed bleeding is the major adverse event in upper gastrointestinal endoscopic treatment (UGET)." | ( Abe, H; Asano, N; Fujimori, K; Fushimi, K; Hatta, W; Imatani, A; Jin, X; Kanno, T; Koike, T; Masamune, A; Nakagawa, K; Nakamura, T; Nakaya, N; Ogata, Y; Saito, M; Tarasawa, K; Uno, K, 2021) |
| "Major bleeding is defined as a composite of major hematoma >4 cm, hematocrit drop >15, and gastrointestinal bleeding." | ( Ben-Dor, I; Bernardo, NL; Case, BC; Chezar-Azerrad, C; Forrestal, BJ; Garcia-Garcia, HM; Hashim, H; Medranda, GA; Satler, LF; Shea, C; Waksman, R; Yerasi, C; Zhang, C, 2021) |
| "Perioperative bleeding is one of the major comorbidities associated with surgery." | ( DiNardo, JA; Koutsogiannaki, S; Yuki, K, 2021) |
| "Excessive bleeding is an important complication of radical cystectomy." | ( Fathi, M; Lashay, A; Massoudi, N; Nik, MA; Nooraei, N, 2021) |
| "Bleeding is an important cause of short-term morbidity and rarely mortality and can also have long-term consequences that are often under-appreciated." | ( Chan, NC; Eikelboom, JW; Xu, K, 2021) |
| "Bleeding is the leading cause of maternal mortality in the world." | ( Boet, S; Burns, JK; Deng, MX; Edwards, W; Etherington, C; Hurskainen, T; Martin Calderon, L; Moher, D, 2022) |
| "Nasal bleeding is the most common complication during nasotracheal intubation (NTI)." | ( Hashimoto, M; Hoshijima, H; Kako, E; Kamimura, Y; Okuda, M; Okumura, Y; Sato-Boku, A; Sento, Y; Sobue, K; Suzuki, F; Tachi, N, 2021) |
| "Bleeding is an untoward outcome in the management of elderly patients with acute coronary syndrome (ACS)." | ( Alaamri, S; Dalbhi, SA, 2021) |
| "However, bleeding is sometimes problematic." | ( Goto, T; Kawakami, H; Lee, HA; Mihara, T; Sato, H, 2021) |
| "The risk of bleeding is high in East Asians, whether East Asian patients with acute coronary syndrome choose ticagrelor or clopidogrel is still controversial." | ( Bai, N; Ma, Y; Niu, Y; Shang, YS; Wang, ZL; Zhong, PY, 2022) |
| "Bleeding is a common reason for discontinuation of Cu-IUDs and LNG-IUDs." | ( Chawla, R; Costescu, D; Hughes, R; Merz, M; Teal, S, 2022) |
| "Perioperative bleeding is common in patients undergoing noncardiac surgery." | ( Aguado, HJ; Alfonsi, P; Amir, M; Astrakov, SV; Balasubramanian, K; Bangdiwala, SI; Belley-Côté, EP; Bhatt, K; Borges, FK; Cafaro, T; Chan, MTV; Conen, D; Copland, I; de Nadal, M; Devereaux, PJ; Duceppe, E; Efremov, S; Eikelboom, J; Fleischmann, E; Garg, AX; Gross, PL; Guyatt, G; Kleinlugtenbelt, YV; Lamy, A; Landoni, G; Leslie, K; Likhvantsev, VV; Lomivorotov, V; Marcucci, M; Martínez-Zapata, MJ; McGillion, MH; McIntyre, W; Meyhoff, CS; Ofori, SN; Painter, TW; Paniagua, P; Parlow, JL; Patel, A; Polanczyk, CA; Prystajecky, M; Rao, M; Richards, T; Roshanov, PS; Ruetzler, K; Schmartz, D; Sessler, DI; Short, TG; Spence, J; Stillo, D; Szczeklik, W; Tandon, V; Torres, D; Turan, A; VanHelder, T; Vincent, J; Wang, CY; Wang, MK; Whitlock, RP; Wittmann, M; Wu, WKK; Xavier, D; Yusuf, S, 2022) |
| "Bleeding is the most common adverse reaction to aspirin and can lead to drug discontinuation or even be life-threatening in the secondary prevention of stroke or transient ischemic attack." | ( Cheng, J; Deng, X; Li, H; Ma, Y; Shi, T; Wang, X; Wu, Y; Zhang, Z; Zhu, Q, 2022) |
| "Bleeding is one of the most common complications associated with MCS, and management can be challenging due to need for systemic anticoagulation." | ( Angelidis, IK; Budd, AN; Malsin, ES; Patel, S; Pawale, A; Smith, S, 2022) |
| "If bleeding is suspected, hemogram control is the most appropriate option." | ( Akman, M, 2022) |
| "Postprocedural bleeding is mostly manageable with a subsequent endoscopic procedure." | ( Cyrany, J; Malý, R; Rejchrt, S; Tachecí, I, 2022) |
| "Pericardial bleeding is a rare but life-threatening complication of atrial fibrillation (AF) ablation." | ( Allison, JD; Arkles, J; Barrett, C; Callans, D; D'Souza, B; Frankel, DS; Garcia, F; Heist, EK; Luebbert, J; Marchlinski, FE; Tzou, W; Zghaib, T, 2023) |
| "Bleeding is a serious complication of cardiopulmonary bypass (CPB) in neonates." | ( Boorman, D; Brown, AC; Downey, LA; Guzzetta, NA; Moiseiwitsch, N; Nellenbach, KA, 2023) |
| "Bleeding is a major adverse event during clopidogrel treatment in patients with acute coronary syndrome (ACS)." | ( Chen, BL; Dai, W; Mo, ZZ; Peng, YY; Tang, J; Wang, G; Yuan, Z; Zhang, W; Zhou, WL, 2023) |
| "Cyst bleeding is typically a self-limited event." | ( Chebib, FT; Chedid, M; Duriseti, P; Hanna, C; Potrezke, TA; Radhakrishnan, Y, 2023) |
| "Bleeding is one of the most serious side effects of antiplatelet drugs." | ( Gao, X; Huan, X; Huang, X; Li, Y; Zhang, T, 2023) |
| "Postprocedural bleeding is the main complication of percutaneous kidney biopsy (PKB)." | ( Castro, I; Coentrão, L; Diniz, H; Gonçalves, J; Mendonça, L; Relvas, M, 2023) |
| "Stroke and bleeding are complications after transcatheter aortic valve replacement (TAVR)." | ( Brouwer, J; Nijenhuis, VJ; Ten Berg, JM; van Bergeijk, KH; van den Heuvel, AFM; van der Werf, HW; van Ginkel, DJ; Voors, AA; Wykrzykowska, JJ, 2023) |
| "Uncontrolled bleeding is the leading cause of death, and the death risk of bleeding from coagulopathy is even higher." | ( Hu, E; Lan, G; Li, Q; Liu, L; Lu, B; Lu, F; Qiu, H; Xie, R; Xu, Q; Yu, K; Zhang, Y, 2023) |
| "Ulcerative arterial bleeding is characterized by sudden onset, rapid disease development, and high mortality, which is a great challenge for clinicians to treat, specially bleeding in areas where endoscopic operation is difficult, or in the case of diffuse bleeding, tumor bleeding, and recurrent bleeding." | ( Fan, Y; Liang, J; Ni, P; Shan, J; Xiong, S; Ye, S; Yuan, T; Zhang, X; Zhong, M, 2023) |
| "Uncontrolled bleeding is one of the leading causes of human mortality." | ( Ao, MZ; Chen, XJ; Lei, MJ; Lei, ZY; Liu, P; Xu, H; Yu, LJ, 2023) |
| "Critical bleeding is associated with a high mortality rate in patients with trauma." | ( Benger, JR; Brohi, K; Cotton, BA; Curry, N; Davenport, R; Deary, A; Edwards, A; Evans, A; Fox, EE; Green, L; Lucas, J; Shanmugaranjan, S; Sharma, R; Stanworth, SJ; Thomas, H; Wade, CE, 2023) |