Drug used to cause constriction of the blood vessels.
| Member | Definition | Class |
|---|
| 1-methyl-d-lysergic acid butanolamide | A synthetic ergot alkaloid, structurally related to the oxytocic agent methylergonovine and to the potent hallucinogen LSD and used prophylactically to reduce the frequency and intensity of severe vascular headaches. | methysergide |
| 8-epi-prostaglandin f2alpha | An isoprostane that is prostaglandin F2alpha having inverted stereochemistry at the 8-position. | 8-epi-prostaglandin F2alpha |
| 8-isoprostaglandin e2 | A prostanoid that is prostaglandin E2 having inverted stereochemistry at the 8-position. | 8-epi-prostaglandin E2 |
| almotriptan | An indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position. | almotriptan |
| cesium chloride | The inorganic chloride salt of caesium; each caesium ion is coordinated by eight chlorine ions. | caesium chloride |
| cocaine | A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. | cocaine |
| corbadrine | A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | (-)-alpha-Methylnoradrenaline; alpha-methylnoradrenaline |
| diadenosine 5',5''''-p1,p6-hexaphosphate | A diadenosyl hexaphosphate in which the two adenosin-5'-yl groups are attached at the P(1) and P(6) positions. | P(1),P(6)-bis(5'-adenosyl)hexaphosphate |
| dihydroergotamine | Ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension. | dihydroergotamine |
| dihydroergotamine mesylate | The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotension. | dihydroergotamine mesylate |
| droxidopa | A serine derivative that is L-serine substituted at the beta-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension | droxidopa |
| eletriptan | An N-alkylpyrrolidine, that is N-methylpyrrolidine in which the pro-R hydrogen at position 2 is replaced by a {5-[2-(phenylsulfonyl)ethyl]-1H-indol-3-yl}methyl group. | eletriptan |
| ephedrine | A phenethylamine alkaloid that is 2-phenylethanamine substituted by a methyl group at the amino nitrogen and a methyl and a hydroxy group at position 2 and 1 respectively. | (-)-ephedrine |
| ergotamine | A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10. | ergotamine |
| felypressin | A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is used as a vasoconstrictor in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth. | felypressin |
| leukotriene b4 | A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway. | leukotriene B4 |
| metaraminol | A member of the class of phenylethanolamines that is 2-amino-1-phenylethanol substituted by a methyl group at position 2 and a phenolic hydroxy group at position 1. A sympathomimetic agent , it is used in the treatment of hypotension. | metaraminol |
| midodrine | An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydrochloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. | midodrine |
| midodrine hydrochloride | A hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. | midodrine hydrochloride |
| naratriptan | | naratriptan |
| nitro-bis(2,4-pentanedionato)(pyridine)cobalt(iii) | A diadenosyl pentaphosphate having the two 5'-adenosyl residues attached at the P(1)- and P(5)-positions. | P(1),P(5)-bis(5'-adenosyl) pentaphosphate |
| oxymetazoline | A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion. | oxymetazoline |
| oxymetazoline hydrochloride | A hydrochloride salt resulting from the reaction of equimolar quantities of oxymetazoline and hydrogen chloride. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used to relieve nasal congestion. | oxymetazoline hydrochloride |
| pd 123319 | An imidazopyridine consisting of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine having 4-(dimethylamino)-3-methylbenzyl, diphenylacetyl and carboxy and groups at positions 1, 5 and 6 respectively | PD123319 |
| phenylephrine | A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring. | phenylephrine |
| pseudoephedrine | A member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group. | pseudoephedrine |
| rizatriptan | | rizatriptan |
| st 1059 | An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-amino-1-hydroxyethyl group. The immediate and active metabolite of midrodine, it is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. Midrodine is used (generally as its hydrochloride salt) as a prodrug for deglymidodrine, which acts as a peripheral vasoconstrictor in the treatment of certain hypotensive states. | deglymidodrine |
| sumatriptan | A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used (in the form of its succinate salt) for the acute treatment of migraine with or without aura in adults. | sumatriptan |
| tetrahydrozoline hydrochloride | The hydrochloride salt of tetryzoline. It is used as a nasal decongestant. | tetrahydrozoline hydrochloride |
| u 0126 | An aryl sulfide that is (2Z,3Z)-bis[amino(sulfanyl)methylidene]butanedinitrile in which the sulfanyl hydrogens are replaced by 2-aminophenyl groups. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties. | U0126 |
| zolmitriptan | A member of the class of tryptamines that is N,N-dimethyltryptamine in which the hydrogen at position 5 of the indole ring has been replaced by a [(4S)-2-oxo-1,3-oxazolidin-4-yl]methyl group. A serotonin 5-HT1 B and D receptor agonist, it is used for the treatment of migraine. | zolmitriptan |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 1.7802 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 0.4467 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 14.0693 | 3 | 7 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 54.9477 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 28.4864 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 32.4648 | 2 | 2 |
| AR protein | Homo sapiens (human) | Potency | 17.3420 | 3 | 4 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 36.6108 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.5962 | 2 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0034 | 2 | 4 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 25.4556 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 1.7783 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 18.0490 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 20.8114 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 1.2956 | 2 | 5 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.3602 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 7.0627 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 43.2152 | 1 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 1.2956 | 2 | 5 |
| chaperonin GroEL | Methanococcus maripaludis S2 | Potency | 100.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.6692 | 2 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 3.9472 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 5.2999 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 7.2999 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 20.3068 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 5.2739 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.9541 | 2 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 5.6298 | 1 | 3 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.9588 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 1.7783 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.9221 | 3 | 3 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 14.8329 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 17.9998 | 7 | 11 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 4.7234 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 12.8699 | 4 | 11 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 29.8470 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 13.8029 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| GALC protein | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 20.3068 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 2.2106 | 1 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 10.6660 | 2 | 7 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 9.5358 | 3 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 19.7603 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 16.1285 | 1 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 29.8493 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 6.2214 | 2 | 7 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 20.8954 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 49.5204 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.3049 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.8029 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 2 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 14.3374 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.8564 | 1 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 6.3010 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 39.8107 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 26.3517 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 9.1063 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 15.2858 | 2 | 6 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 55.2238 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.1549 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 14.7940 | 1 | 2 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 25.5748 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 75.6863 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 31.6680 | 1 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 8.4120 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 39.9855 | 3 | 5 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 10.2918 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 17.0813 | 1 | 5 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 21.3393 | 2 | 3 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 6.5812 | 2 | 4 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 7.9433 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 11.8832 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 47.9904 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.6302 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 0.0211 | 1 | 1 |
| RGS12 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 3.1230 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 3.1230 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 0.0082 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 27.5946 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 18.2563 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.7825 | 2 | 14 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 3.1929 | 3 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 7.8758 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.4242 | 2 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 21.0381 | 6 | 10 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 16.9165 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 13.3081 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 27.9478 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 29.8493 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.4034 | 4 | 4 |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | IC50 | 0.4500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.2902 | 2 | 5 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.2723 | 8 | 13 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.1528 | 2 | 5 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | IC50 | 0.0154 | 7 | 9 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.2028 | 1 | 4 |
| 5-hydroxytryptamine receptor 1B | Gorilla gorilla gorilla (western lowland gorilla) | Ki | 0.0064 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Ki | 0.0135 | 16 | 20 |
| 5-hydroxytryptamine receptor 1B | Oryctolagus cuniculus (rabbit) | Ki | 0.0012 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.1528 | 2 | 5 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | IC50 | 0.2333 | 9 | 11 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.0610 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Sus scrofa (pig) | IC50 | 0.0275 | 4 | 4 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 0.0070 | 18 | 25 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1E | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Homo sapiens (human) | Ki | 0.0257 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 4.5310 | 4 | 6 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 4.1201 | 4 | 4 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.2915 | 4 | 6 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.1015 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 1.0221 | 1 | 3 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.6505 | 1 | 3 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 4.5772 | 6 | 8 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.1263 | 1 | 3 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.6505 | 2 | 2 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | IC50 | 4.2902 | 5 | 7 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | IC50 | 3.9811 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.6505 | 2 | 2 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | IC50 | 4.0044 | 3 | 5 |
| 5-hydroxytryptamine receptor 3B | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | IC50 | 3.9811 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.6505 | 2 | 2 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | IC50 | 4.0044 | 3 | 5 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | IC50 | 4.0044 | 3 | 5 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | IC50 | 4.0044 | 3 | 5 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.2413 | 1 | 3 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.1263 | 1 | 3 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | IC50 | 0.5012 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 0.0215 | 4 | 5 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.5584 | 1 | 3 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.2591 | 1 | 3 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.3640 | 2 | 3 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.1568 | 2 | 2 |
| Adenylate cyclase | Arthrospira platensis | IC50 | 70.0000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 0.2900 | 2 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 10.0000 | 2 | 3 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6400 | 1 | 1 |
| Alpha-1A adrenergic receptor | Bos taurus (cattle) | Ki | 0.4732 | 1 | 2 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.1378 | 3 | 4 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.0981 | 4 | 6 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6400 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.5842 | 3 | 4 |
| Alpha-1B adrenergic receptor | Mesocricetus auratus (golden hamster) | Ki | 3.8204 | 3 | 4 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 6.1000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.9740 | 1 | 3 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6400 | 1 | 1 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.5654 | 3 | 5 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 1.9906 | 4 | 5 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0087 | 1 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | Ki | 0.0015 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.1482 | 19 | 25 |
| Alpha-2A adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5438 | 15 | 20 |
| Alpha-2A adrenergic receptor | Sus scrofa (pig) | Ki | 0.0210 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.4269 | 1 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.3721 | 17 | 22 |
| Alpha-2B adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5840 | 17 | 22 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.8850 | 1 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.1118 | 18 | 24 |
| Alpha-2C adrenergic receptor | Mus musculus (house mouse) | Ki | 0.0913 | 3 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5438 | 15 | 20 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 0.0700 | 1 | 5 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.3380 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 308.2725 | 2 | 4 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 551.7000 | 2 | 4 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | IC50 | 4.1420 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 2.3920 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 13.0000 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 2.7610 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 1.8980 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 286.8140 | 3 | 5 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carboxypeptidase M | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Chymotrypsinogen B | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 2.9997 | 2 | 3 |
| D | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 2.0615 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 1.0305 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.0066 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.0741 | 2 | 3 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.2740 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.0048 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0016 | 1 | 2 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | IC50 | 2.9168 | 14 | 14 |
| Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens (human) | IC50 | 2.7334 | 10 | 10 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0126 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| Fatty acid-binding protein, heart | Homo sapiens (human) | IC50 | 0.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| GTP:AMP phosphotransferase AK3, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 0.3000 | 1 | 1 |
| guanine nucleotide-binding protein subunit alpha-15 | Homo sapiens (human) | IC50 | 29.8680 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | IC50 | 0.0019 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | Ki | 0.1327 | 4 | 4 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | Ki | 0.2630 | 2 | 2 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 98.1000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 77.1000 | 1 | 1 |
| Malate dehydrogenase | Thermus thermophilus | IC50 | 100.0000 | 1 | 1 |
| MAP kinase-activated protein kinase 5 | Homo sapiens (human) | IC50 | 50.0000 | 2 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 4.7500 | 1 | 2 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 12.6000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 61.3985 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Sus scrofa (pig) | Ki | 0.2344 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 3.2610 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.4550 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 1.3320 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.9570 | 1 | 1 |
| Nischarin | Homo sapiens (human) | Ki | 0.0062 | 1 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 5.5410 | 6 | 6 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 0.2900 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 107.3600 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 107.3600 | 1 | 1 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.0040 | 2 | 3 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 8.8300 | 1 | 1 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 1.3496 | 47 | 67 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | Ki | 0.8500 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 25.2466 | 26 | 41 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.3796 | 34 | 34 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.4281 | 30 | 33 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.2861 | 22 | 22 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.6163 | 30 | 32 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.5442 | 23 | 23 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.8885 | 15 | 18 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.3792 | 31 | 34 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.5521 | 18 | 27 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 49.9000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 3.0640 | 1 | 1 |
| trace amine-associated receptor 1 | Homo sapiens (human) | IC50 | 0.1571 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 3.2277 | 13 | 15 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 2.3643 | 15 | 18 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | Ki | 0.4900 | 1 | 1 |
| Type-1 angiotensin II receptor | Homo sapiens (human) | Ki | 0.0120 | 1 | 1 |
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| Type-2 angiotensin II receptor | Homo sapiens (human) | Ki | 120.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 3.1600 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 6.4990 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |