Page last updated: 2024-08-05 15:45:31

EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor

An EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor that interferes with the action of Delta(24)-sterol reductase (EC 1.3.1.72).

ChEBI ID: 78728

Members (2)

MemberDefinitionClass
brassicasterolAn 3beta-sterol that is (22E)-ergosta-5,22-diene substituted by a hydroxy group at position 3beta. It is a phytosterol found in marine algae, fish, and rapeseed oil.brassicasterol
u 18666aA hydrochloride obtained by reaction of 3beta-(2-diethylaminoethoxy)androst-5-en-17-one with one equivalent of hydrochloric acid. It is a cholesterol synthesis and transport inhibitor.3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride

Research

Studies (260)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199028 (10.77)18.7374
1990's33 (12.69)18.2507
2000's87 (33.46)29.6817
2010's92 (35.38)24.3611
2020's20 (7.69)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2 (0.76%)5.53%
Reviews12 (4.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other249 (94.68%)84.16%

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency7.943311
estrogen nuclear receptor alphaHomo sapiens (human)Potency6.007011
pregnane X nuclear receptorHomo sapiens (human)Potency1.995311
TDP1 proteinHomo sapiens (human)Potency13.188022
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency18.045922