Page last updated: 2024-08-05 15:35:11

protein kinase agonist

An agonist that selectively binds to and activates a protein kinase receptor.

ChEBI ID: 64106

Members (4)

MemberDefinitionClass
8-((4-chlorophenyl)thio)cyclic-3',5'-ampA 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the hydrogen at position 2 on the purine fragment is replaced by a 4-chlorophenylthio group.8-(4-chlorophenylthio)-cAMP
8-((4-chlorophenyl)thio)cyclic-3',5'-gmpA 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP in which the hydrogen at position 2 on the purine fragment is replaced by a 4-chlorophenylthio group.8-(4-chlorophenylthio)-cGMP
8-bromo cyclic adenosine monophosphateA 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.8-Br-cAMP
monobutyryl cyclic ampA 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP in which the exocyclic amino group on the purine fragment is carrying a butyryl substituent.N(6)-butyryl-cAMP

Research

Studies (4,271)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,003 (23.48)18.7374
1990's1,930 (45.19)18.2507
2000's1,040 (24.35)29.6817
2010's288 (6.74)24.3611
2020's10 (0.23)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials5 (0.11%)5.53%
Reviews32 (0.72%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4,404 (99.17%)84.16%

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)IC5049.900026
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)IC5049.900026
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)IC5049.900026
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)IC5049.900026