Roles > mucolytic
Page last updated: 2024-08-05 15:14:13

mucolytic

A compound that alters the structure of mucus so as to decrease its viscosity and thereby facilitate its removal by ciliary action and expectoration. Compare with antitussives, which suppress the cough reflex, and expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing.

ChEBI ID: 77034

Members (8)

MemberDefinitionClass
acetylcysteineAn N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.N-acetyl-L-cysteine
bromhexineA substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).bromhexine
bromhexine hydrochlorideA hydrochloride resulting from the reaction of equimolar amounts of bromhexine and hydrogen chloride. It is used as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).bromhexine hydrochloride
carbocysteineAn L-cysteine thioether that is L-cysteine in which the hydrogen of the thiol group has been replaced by a carboxymethyl group.S-carboxymethyl-L-cysteine
eprazinoneA member of the class of piperazines in which the two amino hydrogens of piperazine are replaced by 2-benzoylpropyl and 2-ethoxy-2-phenylethyl groups.eprazinone
eprazinone hydrochlorideA hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid.eprazinone hydrochloride
letosteineA dicarboxylic acid monoester that is the monoethyl ester of 2-{2-[(carboxymethyl)sulfanyl]ethyl}-1,3-thiazolidine-4-carboxylic acid. A mucolytic used in the treatment of chronic bronchopneumopathies and related conditions.letosteine
mecysteineAn L-cysteinyl ester resulting from the formal condensation of the carboxylic acid group of L-cysteine with methanol. It is used (as the hydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough.methyl L-cysteinate

Research

Studies (14,861)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,831 (12.32)18.7374
1990's1,979 (13.32)18.2507
2000's4,365 (29.37)29.6817
2010's5,246 (35.30)24.3611
2020's1,440 (9.69)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,248 (7.94%)5.53%
Reviews1,060 (6.75%)6.00%
Case Studies569 (3.62%)4.05%
Observational32 (0.20%)0.25%
Other12,804 (81.49%)84.16%

Protein Targets (98)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency0.025111
acetylcholinesteraseHomo sapiens (human)Potency25.575422
AR proteinHomo sapiens (human)Potency14.346746
aryl hydrocarbon receptorHomo sapiens (human)Potency26.603211
arylsulfatase AHomo sapiens (human)Potency37.933011
Ataxin-2Homo sapiens (human)Potency11.220211
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency26.854511
Bloom syndrome protein isoform 1Homo sapiens (human)Potency1.000022
Cellular tumor antigen p53Homo sapiens (human)Potency34.146622
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency25.118911
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency1.412511
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency89.125111
cytochrome P450 2C9, partialHomo sapiens (human)Potency24.056613
cytochrome P450 2D6Homo sapiens (human)Potency0.057412
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency12.589322
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency10.807623
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency26.603211
D(1A) dopamine receptorHomo sapiens (human)Potency5.804511
dopamine D1 receptorHomo sapiens (human)Potency0.020611
estrogen nuclear receptor alphaHomo sapiens (human)Potency22.259369
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency17.239557
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency9.240914
farnesoid X nuclear receptorHomo sapiens (human)Potency28.183811
flap endonuclease 1Homo sapiens (human)Potency26.679511
GVesicular stomatitis virusPotency24.056613
GABA theta subunitRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency12.589311
gemininHomo sapiens (human)Potency18.425524
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.002811
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.118711
heat shock protein beta-1Homo sapiens (human)Potency33.488912
Histone H2A.xCricetulus griseus (Chinese hamster)Potency61.931511
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency24.056613
huntingtin isoform 2Homo sapiens (human)Potency35.481311
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency30.106511
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency24.056616
Interferon betaHomo sapiens (human)Potency24.056613
lamin isoform A-delta10Homo sapiens (human)Potency15.811912
LuciferasePhotinus pyralis (common eastern firefly)Potency40.533411
Microtubule-associated protein tauHomo sapiens (human)Potency24.702812
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency12.589311
NFKB1 protein, partialHomo sapiens (human)Potency4.466822
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency17.248523
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency26.832511
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency5.964022
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency18.910822
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency37.594713
phosphopantetheinyl transferaseBacillus subtilisPotency37.646012
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency7.875812
pregnane X nuclear receptorHomo sapiens (human)Potency11.705224
pregnane X receptorRattus norvegicus (Norway rat)Potency31.622811
progesterone receptorHomo sapiens (human)Potency8.412711
RAR-related orphan receptor gammaMus musculus (house mouse)Potency13.333211
regulator of G-protein signaling 4Homo sapiens (human)Potency0.237611
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency34.759324
retinoid X nuclear receptor alphaHomo sapiens (human)Potency17.271312
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency15.241013
survival motor neuron protein isoform dHomo sapiens (human)Potency1.584911
TDP1 proteinHomo sapiens (human)Potency24.660224
ThrombopoietinHomo sapiens (human)Potency31.622822
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency29.665525
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.562311
thyroid stimulating hormone receptorHomo sapiens (human)Potency26.630844
USP1 protein, partialHomo sapiens (human)Potency39.810711
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency14.870422
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency13.861622
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency39.810711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bile salt export pumpHomo sapiens (human)IC5020.270011
Cytochrome P450 2D6Homo sapiens (human)IC500.195811
Histone deacetylase 1Homo sapiens (human)IC503,160.000011
Histone deacetylase 11 Homo sapiens (human)IC503,160.000011
Histone deacetylase 2Homo sapiens (human)IC503,160.000011
Histone deacetylase 3Homo sapiens (human)IC503,160.000011
Histone deacetylase 4Homo sapiens (human)IC503,160.000011
Histone deacetylase 5Homo sapiens (human)IC503,160.000011
Histone deacetylase 6Homo sapiens (human)IC503,160.000011
Histone deacetylase 7Homo sapiens (human)IC503,160.000011
Histone deacetylase 8Homo sapiens (human)IC503,160.000011
Histone deacetylase 9Homo sapiens (human)IC503,160.000011
Kinesin-like protein KIF11Homo sapiens (human)IC5063.000011
Polyamine deacetylase HDAC10Homo sapiens (human)IC503,160.000011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC500.061011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki0.025011
Sodium-dependent serotonin transporterHomo sapiens (human)IC502.091011
Sodium-dependent serotonin transporterHomo sapiens (human)Ki1.111011
Solute carrier family 22 member 6Rattus norvegicus (Norway rat)Ki2,000.000011
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