A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy.
ChEBI ID: 64912
| Member | Definition | Class |
|---|---|---|
| 3-nitropropionic acid | A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group. | 3-nitropropanoic acid |
| azadiradione | A tetracyclic triterpenoid that is 4,4,8-trimethylandrosta-1,14-diene substituted by oxo groups at positions 3 and 16, an acetoxy group at position 7 and a furan-3-yl group at position 17. Isolated from Azadirachta indica, it exhibits antimycobacterial and anti-inflammatory activities. | azadiradione |
| canthin-6-one | An indole alkaloid that is 6H-indolo[3,2,1-de][1,5]naphthyridine substituted by an oxo group at position 6. | canthin-6-one |
| dehydrocostus lactone | An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone. | dehydrocostus lactone |
| ergosterol-5,8-peroxide | An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities. | ergosterol peroxide |
| ermanin | A dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. | 3,4'-dimethylkaempferol |
| physalin d | A physalin with antimalarial and antimycobacterial activities isolated from Physalis angulata. | physalin D |
| sakuranetin | A flavonoid phytoalexin that is (S)-naringenin in which the hydroxy group at position 7 is replaced by a methoxy group. | sakuranetin |
| undecanal | A saturated fatty aldehyde formally arising from reduction of the carboxylic acid group of undecanoic acid. It is a component of essential oils from citrus plants like Citrus reticulata. | undecanal |
| viridiflorol | A carbotricyclic compound that is (1aS,4aR,7aR,7bR)-decahydro-1H-cyclopropa[e]azulene carrying four methyl substituents at positions 1, 1, 4 and 7 as well as a hydroxy substituent at position 4. It is a sesquiterpenoid isolated from several plant species and is a strong feeding deterrent for the melaleuca weevil that retards larval development. | viridiflorol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 33 (2.46) | 18.7374 |
| 1990's | 162 (12.05) | 18.2507 |
| 2000's | 503 (37.43) | 29.6817 |
| 2010's | 503 (37.43) | 24.3611 |
| 2020's | 143 (10.64) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.07%) | 5.53% |
| Reviews | 49 (3.53%) | 6.00% |
| Case Studies | 6 (0.43%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,332 (95.97%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 29.0344 | 4 | 4 |
| AR protein | Homo sapiens (human) | Potency | 65.4515 | 3 | 3 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 77.1708 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.6310 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 17.7735 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 70.7576 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 47.6885 | 5 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 52.5773 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 0.8199 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 59.6338 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 2.9919 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 70.7576 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 39.6411 | 2 | 2 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 9.2670 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0631 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.1096 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 70.7576 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 55.4492 | 2 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.9713 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 50.7629 | 2 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 0.7079 | 1 | 1 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 30.1475 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 61.2757 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 43.0397 | 2 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 70.7576 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase | Helicobacter pylori | Ki | 0.9000 | 1 | 3 |
| Chain A, ODORANT-BINDING PROTEIN | Sus scrofa (pig) | IC50 | 0.7000 | 1 | 5 |
| Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase | Helicobacter pylori | Ki | 0.9000 | 1 | 3 |
| Chain B, Odorant-binding Protein | Sus scrofa (pig) | IC50 | 0.7000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 45.5000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 21.8000 | 1 | 1 |
| Delta-aminolevulinic acid dehydratase | Escherichia coli K-12 | Ki | 44,900.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Isocitrate lyase | Candida albicans | IC50 | 32.6164 | 11 | 11 |
| Isocitrate lyase | Mycobacterium tuberculosis H37Rv | IC50 | 116.0000 | 1 | 1 |
| Isocitrate lyase 1 | Mycobacterium tuberculosis CDC1551 | IC50 | 14.7000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 41.2667 | 1 | 3 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 12.9250 | 2 | 2 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 890.0000 | 1 | 1 |
| Taste receptor type 2 member 31 | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Transcriptional activator Myb | Gallus gallus (chicken) | IC50 | 9.5450 | 1 | 2 |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Escherichia coli K-12 | IC50 | 50.0000 | 1 | 1 |
| UDP-N-acetylglucosamine 1-carboxyvinyltransferase | Pseudomonas aeruginosa PAO1 | IC50 | 50.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Bile acid receptor | Mus musculus (house mouse) | EC50 | 0.8500 | 1 | 1 |
| Retinoic acid receptor RXR-alpha | Mus musculus (house mouse) | EC50 | 0.8500 | 1 | 1 |