An agonist at the neurokinin-1 receptor.
ChEBI ID: 194137
| Member | Definition | Class |
|---|---|---|
| substance p | A neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. | substance P |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,893 (29.50) | 18.7374 |
| 1990's | 6,057 (36.52) | 18.2507 |
| 2000's | 3,342 (20.15) | 29.6817 |
| 2010's | 1,886 (11.37) | 24.3611 |
| 2020's | 408 (2.46) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 277 (1.60%) | 5.53% |
| Reviews | 1,120 (6.48%) | 6.00% |
| Case Studies | 82 (0.47%) | 4.05% |
| Observational | 13 (0.08%) | 0.25% |
| Other | 15,797 (91.37%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 21.1923 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Neuromedin-K receptor | Homo sapiens (human) | IC50 | 0.1250 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 0.2455 | 1 | 1 |
| Substance-K receptor | Mesocricetus auratus (golden hamster) | IC50 | 0.1480 | 1 | 1 |
| Substance-K receptor | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | Ki | 0.1020 | 1 | 1 |
| Substance-K receptor | Oryctolagus cuniculus (rabbit) | Ki | 0.1020 | 1 | 2 |
| Substance-P receptor | Homo sapiens (human) | IC50 | 0.0011 | 8 | 8 |
| Substance-P receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0005 | 4 | 4 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0505 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | Ki | 0.0016 | 1 | 1 |
| Substance-P receptor | Rattus norvegicus (Norway rat) | Ki | 0.0011 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | EC50 | 0.0010 | 1 | 1 |
| Growth hormone secretagogue receptor type 1 | Homo sapiens (human) | EC50 | 0.0660 | 1 | 1 |
| Mas-related G-protein coupled receptor member X2 | Homo sapiens (human) | EC50 | 3.1000 | 2 | 2 |
| Neuromedin-K receptor | Homo sapiens (human) | EC50 | 0.7930 | 1 | 1 |
| Neuromedin-K receptor | Rattus norvegicus (Norway rat) | EC50 | 7.5000 | 1 | 1 |
| Substance-K receptor | Rattus norvegicus (Norway rat) | EC50 | 0.1670 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | EC50 | 0.0006 | 4 | 4 |