Page last updated: 2024-09-27

Hypernutrition

An imbalanced NUTRITIONAL STATUS resulting from excessive intake of nutrients. Generally, overnutrition generates an energy imbalance between food consumption and energy expenditure leading to disorders such as OBESITY.

Synonyms(2)

Synonym
Hypernutrition
Overnutrition

Research Excerpts

Overview

ExcerptReference
"And overnutrition is a leading cause of obesity."( Cheng, H; Ding, Y; Hou, N; Hu, X; Mao, J; Wang, J; Xiao, Y; Yang, C; Zhang, X, 2013)
"Although under- and overnutrition are opposite in nature, both have several common drivers, suggesting that an integrated approach might work better in tackling DBM."( Mittal, N; Vollmer, S, 2020)

Context

ExcerptReference
"Human overnutrition has caused a rise in the prevalence of obesity in recent years."( de Souza, EP; Martins, MR; Moura, AS; Vieira, AK, 2008)
"Overnutrition has been achieved in a number of different ways, including forced feeding, administration of high-fat diets, the use of genetically hyperphagic animals, or a combination of these approaches."( Larter, CZ; Yeh, MM, 2008)
"Iron overnutrition has been implicated with a higher risk of developing metabolic and cardiovascular diseases, including metabolic syndrome (MetS), whereas iron deficiency anemia exacerbates many underlying chronic conditions."( Chiang, KM; Pan, WH; Timoteo, VJ, 2022)

Actions

ExcerptReference
"Overnutrition affects physiological parameters, such as body weight, visceral, and subcutaneous fat content, in males, while females present alterations in hypothalamic POMC mRNA levels."( Carrillo, B; Chowen, JA; Collado, P; Díaz, F; Pérez-Izquierdo, MÁ; Pinos, H, 2019)

Treatment

ExcerptReference
"Early postnatal overnutrition causes metabolic alterations that can be permanently attenuated with the administration of a leptin antagonist during a restricted developmental window."( Bouret, SG; Caron, E; Colldén, G, 2022)

Research

Studies (225)

TimeframeStudies, This Condition (%)All Conditions %
pre-19905 (2.22)23.3326
1990's1 (0.44)12.5806
2000's30 (13.33)18.1394
2010's144 (64.00)28.8240
2020's45 (20.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
ammonium hydroxide0low10
butyric acid0low10
carnitine0low20
choline0low10
3-hydroxybutyric acid0low10
3,4-dihydroxyphenylacetic acid0low10
lactic acid0low30
formaldehyde0low10
glycine0low10
glycerol0low10
iodine0low80
niacin0low10
nitrites0low10
palmitic acid0low20
taurine0low10
thiamine0low10
uric acid0low10
urea0low10
homovanillic acid0low10
albuterol0low10
aspirin0low10
desipramine0low10
erythrosine0low10
ether0low10
fenofibrate0low10
fluoxetine0low40
metformin0low20
methadone0low10
methylphenidate0low10
corticosterone0low30
thyroxine0low40
triiodothyronine0low50
serine0low10
aspartic acid0low10
glutamine0low30
sucrose0low40
methacholine chloride0low10
methionine0low30
arginine0low20
bisphenol a0low20
pyrrolidonecarboxylic acid0low10
trehalose0low10
thiamine pyrophosphate0low10
luminol0low10
malondialdehyde0low20
d-alpha tocopherol0low30
s,n,n'-tripropylthiocarbamate0medium21
fructosamine0low10
deuterium0low30
iodine0low10
cetylpyridinium chloride anhydrous0medium11
glutamic acid0low10
s-adenosylmethionine0low10
glucose, (beta-d)-isomer0low10
methacycline0low10
nsc-1727550low20
homocysteine0low10
((18)O)water0low20
reboxetine0low10
cucurbitaceae0low10
angiotensin ii0low20
estradiol 3-benzoate0low10
esi-050low10
glycogen0low10
bradykinin0low10
elastin0low10
naringenin0low10
retinol0medium61
pectins0low10
D-fructopyranose0medium31
digoxin0low10
zinc protoporphyrin ix0low10
vitamin k semiquinone radical0low20
genistein0low10
neurokinin b0low10
cl 3162430low10
25-hydroxyvitamin d 20low10
mocetinostat0low10
cholecystokinin0low20
atrial natriuretic factor0low10
hes1 protein, human0low10
glucagon0low10
neuropeptide y0low50
glucagon-like peptide 10low20
incretins0low10
c-peptide0medium11
phosphatidylcholines0low30
exenatide0low10
heme0low10
ascorbic acid0low10
minocycline0low10
transforming growth factor beta0low20
kiss1 protein, human0low40
rome0low10
peptide yy0medium21
exudates0low20
folic acid0low30
clozapine0low10
clozapine n-oxide0low10
galanin-like peptide0low10
leptin0medium582
pyrimidinones0low10

Protein Targets (971)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A5005
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase3003
thioredoxin reductase180018
USP1 protein, partial120012
TDP1 protein210021
vitamin D3 receptor isoform VDRA5005
importin subunit beta-1 isoform 14004
flap endonuclease 16006
serine/threonine-protein kinase PLK12002
snurportin-14004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
GTP-binding nuclear protein Ran isoform 14004
DNA polymerase eta isoform 12002
DNA polymerase iota isoform a (long)9009
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
geminin160016
DNA polymerase kappa isoform 17007
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0215
Fatty acid-binding protein, intestinal0325
Fatty acid-binding protein, adipocyte0325
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G1001
Fatty acid-binding protein 50224
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140202
Protein skinhead-10101
Monocarboxylate transporter 20101
Solute carrier family 22 member 200303
Solute carrier family 22 member 60303
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
Chain A, TYROSYL-DNA PHOSPHODIESTERASE110011
Chain A, HADH2 protein7007
Chain B, HADH2 protein7007
Chain A, 2-oxoglutarate Oxygenase4004
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10011
Luciferase100010
endonuclease IV2002
RGS121001
phosphopantetheinyl transferase8008
NFKB1 protein, partial6006
GLS protein130013
Microtubule-associated protein tau8008
Thrombopoietin4004
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase5005
apical membrane antigen 1, AMA13003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor110011
hypothetical protein, conserved3003
regulator of G-protein signaling 48008
euchromatic histone-lysine N-methyltransferase 2220022
Bloom syndrome protein isoform 1110011
lysosomal alpha-glucosidase preproprotein4004
peripheral myelin protein 22 isoform 15005
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
intestinal alkaline phosphatase precursor0101
chromobox protein homolog 1120012
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
DNA polymerase beta4004
M-phase phosphoprotein 85005
alkaline phosphatase, germ cell type preproprotein0011
POsterior Segregation0011
muscarinic acetylcholine receptor M19009
lamin isoform A-delta10180018
Prolyl 4-hydroxylase subunit alpha-10101
Sodium-dependent noradrenaline transporter 016319
Zinc finger protein mex-50011
ATP-dependent phosphofructokinase9009
glp-1 receptor, partial9009
estrogen-related nuclear receptor alpha260026
estrogen nuclear receptor alpha320032
NPYLR7B0011
arylsulfatase A8008
thyroid stimulating hormone receptor110011
peripheral myelin protein 22130013
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40708
Bile salt export pump012012
Beta-2 adrenergic receptor0336
Beta-1 adrenergic receptor0134
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Beta-3 adrenergic receptor0325
Delta-type opioid receptor0011
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
Beta-2 adrenergic receptor 0013
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Beta-2 adrenergic receptor0224
Canalicular multispecific organic anion transporter 10707
glucocerebrosidase7007
histone acetyltransferase KAT2A isoform 18008
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
alpha-galactosidase3003
cytochrome P450 2C19 precursor7007
lethal factor (plasmid)100010
Cytochrome P450 3A40507
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase9009
RAR-related orphan receptor gamma180018
GLI family zinc finger 3170017
AR protein250025
cytochrome P450 family 3 subfamily A polypeptide 4170017
glucocorticoid receptor [Homo sapiens]140014
retinoic acid nuclear receptor alpha variant 1220022
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
IDH16006
nuclear factor erythroid 2-related factor 2 isoform 26006
thyroid hormone receptor beta isoform 2150015
nuclear factor erythroid 2-related factor 2 isoform 1190019
lethal(3)malignant brain tumor-like protein 1 isoform I2002
Polyphenol oxidase 20202
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0516
Spike glycoprotein4004
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Ferritin light chain9009
aldehyde dehydrogenase 1 family, member A1100010
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
Carbonic anhydrase 10609
Carbonic anhydrase 207111
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0527
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 0527
Glutamate receptor ionotropic, NMDA 2B0527
Glutamate receptor ionotropic, NMDA 2C0527
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0003
Glutamate receptor ionotropic, NMDA 2D0527
Glutamate receptor ionotropic, NMDA 3B0527
Carbonic anhydrase 40001
Glutamate receptor ionotropic, NMDA 3A0527
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 83003
EWS/FLI fusion protein100010
cytochrome P450 2D6110011
peroxisome proliferator-activated receptor delta140014
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0202
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver0213
Integrin beta-33115
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb3115
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10404
Adenosine receptor A10202
Adenosine receptor A2a0202
Substance-P receptor0303
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma5117
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-184214
Prostaglandin G/H synthase 20202
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10224
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
GALC protein4004
caspase 7, apoptosis-related cysteine protease5005
estrogen receptor 2 (ER beta)9009
nuclear receptor subfamily 1, group I, member 3120012
progesterone receptor100010
retinoid X nuclear receptor alpha140014
farnesoid X nuclear receptor9009
pregnane X nuclear receptor130013
G110011
peroxisome proliferator activated receptor gamma9009
caspase-35005
aryl hydrocarbon receptor8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a140014
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a100010
Histone H2A.x8008
thyroid hormone receptor beta isoform a100010
potassium voltage-gated channel subfamily H member 2 isoform d7007
cytochrome P450 3A4 isoform 18008
Gamma-aminobutyric acid receptor subunit pi83112
Voltage-dependent calcium channel gamma-2 subunit9009
GTPase KRas0011
Interferon beta120012
HLA class I histocompatibility antigen, B alpha chain 110011
Estrogen receptor0729
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Cellular tumor antigen p53150015
Aldo-keto reductase family 1 member B1010010
Androgen receptor0304
Polyunsaturated fatty acid lipoxygenase ALOX150202
Androgen receptor0606
Gamma-aminobutyric acid receptor subunit beta-183112
Gamma-aminobutyric acid receptor subunit delta83112
Gamma-aminobutyric acid receptor subunit gamma-283213
Glutamate receptor 292112
Gamma-aminobutyric acid receptor subunit alpha-583112
Gamma-aminobutyric acid receptor subunit alpha-383112
Gamma-aminobutyric acid receptor subunit gamma-183112
Gamma-aminobutyric acid receptor subunit alpha-283112
Gamma-aminobutyric acid receptor subunit alpha-483112
Gamma-aminobutyric acid receptor subunit gamma-383112
Gamma-aminobutyric acid receptor subunit alpha-683112
Sodium-dependent serotonin transporter012214
5-hydroxytryptamine receptor 60607
Estrogen-related receptor gamma0101
Gamma-aminobutyric acid receptor subunit beta-383112
Gamma-aminobutyric acid receptor subunit beta-283213
Sodium-dependent dopamine transporter 013114
GTP-binding protein Rheb0011
GABA theta subunit83112
Inositol hexakisphosphate kinase 1110011
Estrogen receptor beta0426
Gamma-aminobutyric acid receptor subunit epsilon83112
cytochrome P450 2C9, partial110011
Angiotensin-converting enzyme 0001
B2 bradykinin receptor0101
B2 bradykinin receptor0215
B1 bradykinin receptor0101
Olfactory receptor 51E20044
Chain A, Nitrile Hydratase alpha subunit0101
Chain B, Nitrile Hydratase beta subunit0101
SMAD family member 26006
SMAD family member 36006
Lysine-specific demethylase 4E0101
Free fatty acid receptor 30011
Histone deacetylase 30505
Histone deacetylase 40404
Histone deacetylase 10505
Histone deacetylase 70404
Histone deacetylase 20505
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0303
Histone deacetylase 80404
Histone deacetylase 60404
Histone deacetylase 90303
Histone deacetylase 50404
Methyl-accepting chemotaxis protein NahY0011
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
hypoxia-inducible factor 1 alpha subunit3003
67.9K protein3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
activating transcription factor 69009
thyrotropin-releasing hormone receptor4004
v-jun sarcoma virus 17 oncogene homolog (avian)110011
heat shock protein beta-15005
mitogen-activated protein kinase 17007
nuclear receptor ROR-gamma isoform 16006
survival motor neuron protein isoform d8008
Caspase-20011
Inositol monophosphatase 12002
ATPase family AAA domain-containing protein 54004
Ataxin-26006
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 0608
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-41102
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-21102
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Acetylcholinesterase0404
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Solute carrier family 22 member 10608
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20506
Beta-2 adrenergic receptor0303
Alpha-1D adrenergic receptor0213
Beta-3 adrenergic receptor0112
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
5-hydroxytryptamine receptor 3E0101
ATAD5 protein, partial8008
Fumarate hydratase3003
polyprotein3003
Beta-1 adrenergic receptor 0101
bromodomain adjacent to zinc finger domain 2B5005
Adenylate cyclase type 1 0101
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C9 precursor4004
D(1A) dopamine receptor4004
atrial natriuretic peptide receptor 2 precursor3003
short transient receptor potential channel 6 isoform 10011
transient receptor potential cation channel subfamily V member 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Bile salt export pump0101
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 40819
5-hydroxytryptamine receptor 3B0101
Albumin0022
Muscarinic acetylcholine receptor M20213
Muscarinic acetylcholine receptor M40213
ATP-dependent translocase ABCB10316
Muscarinic acetylcholine receptor M10213
Muscarinic acetylcholine receptor M30213
Muscarinic acetylcholine receptor M40213
5-hydroxytryptamine receptor 1A0202
5-hydroxytryptamine receptor 2C0505
Muscarinic acetylcholine receptor M50213
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0404
Calmodulin-10202
Cytochrome P450 2D60304
Muscarinic acetylcholine receptor M20213
Muscarinic acetylcholine receptor M10415
Cytochrome P450 2C9 0618
Angiotensin-converting enzyme0606
D(2) dopamine receptor0306
5-hydroxytryptamine receptor 2A0505
Alpha-1B adrenergic receptor09110
Beta-1 adrenergic receptor0101
Alpha-2C adrenergic receptor0505
D0202
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 1A0303
Alpha-2B adrenergic receptor0314
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30415
Endothelin receptor type B0101
D(1A) dopamine receptor0203
D(4) dopamine receptor0305
D(1B) dopamine receptor0102
Adenylate cyclase type 30101
Alpha-2C adrenergic receptor0314
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0314
Alpha-1D adrenergic receptor0415
Sodium-dependent dopamine transporter0707
5-hydroxytryptamine receptor 3A0101
Endothelin receptor type B0101
Histamine H2 receptor0202
D(1B) dopamine receptor0202
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A09011
5-hydroxytryptamine receptor 2C0819
5-hydroxytryptamine receptor 1B0303
5-hydroxytryptamine receptor 1D0303
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 1F0303
5-hydroxytryptamine receptor 2B0516
Histamine H1 receptor0101
Histamine H1 receptor0303
Sodium-dependent serotonin transporter0606
5-hydroxytryptamine receptor 7 0202
Cytochrome P450 2C190203
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
5-hydroxytryptamine receptor 2A0101
Histamine H1 receptor0226
D(3) dopamine receptor0507
5-hydroxytryptamine receptor 3A0202
Adenylate cyclase type 80101
5-hydroxytryptamine receptor 2B0415
Alpha-1A adrenergic receptor09110
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor5107
5-hydroxytryptamine receptor 5A0101
Cytochrome P450 2J20405
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
D(2) dopamine receptor0101
D(2) dopamine receptor0303
Calmodulin 0011
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
Potassium voltage-gated channel subfamily H member 20909
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Transporter0202
Cholecystokinin receptor type A0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0606
5-hydroxytryptamine receptor 3D0101
Adenylyl cyclase 7 0101
5-hydroxytryptamine receptor 3C0101
D0202
Histamine H4 receptor0112
5-hydroxytryptamine receptor 3B0202
Transporter0404
Histamine H3 receptor0303
pregnane X receptor3003
nonstructural protein 12002
serine/threonine-protein kinase mTOR isoform 14004
Solute carrier family 22 member 30202
Solute carrier family 22 member 30202
Sex hormone-binding globulin0044
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0011
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Rap guanine nucleotide exchange factor 35005
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
huntingtin isoform 23003
Albumin0022
Tryptophan 5-hydroxylase 10101
5-hydroxytryptamine receptor 60101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 70101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 5 subunit alpha0101
5-hydroxytryptamine receptor 4 0101
Histamine H3 receptor0101
Solute carrier family 22 member 40101
Chain A, Beta-lactamase5005
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, Cruzipain4004
PAX80001
PPM1D protein3003
STAT3, partial0101
Smad32002
NPC intracellular cholesterol transporter 1 precursor3003
cellular tumor antigen p53 isoform a3003
tumor necrosis factor2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
ras-related protein Rab-9A3003
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Solute carrier organic anion transporter family member 1A40205
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
ATP-dependent translocase ABCB10101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
ATP-dependent translocase ABCB10112
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10103
Solute carrier organic anion transporter family member 4C10002
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30304
Solute carrier organic anion transporter family member 1B10305
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Genome polyprotein 0112
chaperonin-containing TCP-1 beta subunit homolog1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
eyes absent homolog 2 isoform a1001
relaxin receptor 1 isoform 11001
Flavin reductase (NADPH)0011
large T antigen0101
Rap guanine nucleotide exchange factor 40101
serine-protein kinase ATM isoform a2002
histone-lysine N-methyltransferase 2A isoform 2 precursor3003
muscleblind-like protein 1 isoform 12002
streptokinase A precursor0011
Glucocorticoid receptor0203
Estrogen receptor0011
Tyrosine-protein kinase Fyn0202
Glycine receptor subunit alpha-10202
Adenosine receptor A30404
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Estrogen receptor beta0011
neuropeptide S receptor isoform A3003
Fatty acid-binding protein, liver0101
Peroxisome proliferator-activated receptor alpha0011
Cruzipain0202
Peroxisome proliferator-activated receptor alpha0011
Peroxisome proliferator-activated receptor gamma0156
Peroxisome proliferator-activated receptor gamma0011
Disintegrin and metalloproteinase domain-containing protein 172002
Peroxisome proliferator-activated receptor alpha1124
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Caspase-71001
caspase-31001
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Sodium-dependent noradrenaline transporter0101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Cytochrome P450 2C80101
Dipeptidyl peptidase 40202
Gamma-aminobutyric acid receptor subunit alpha-10314
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit gamma-20314
Acetylcholinesterase0101
Potassium voltage-gated channel subfamily C member 10101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit alpha-50314
Gamma-aminobutyric acid receptor subunit alpha-30314
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit epsilon0303
Gastrin/cholecystokinin type B receptor 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Gamma-aminobutyric acid receptor subunit alpha-60314
Cytochrome P450 1B10202
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10112
Sodium-dependent serotonin transporter0101
Sodium-dependent dopamine transporter0101
Gamma-aminobutyric acid receptor subunit gamma-10303
Gamma-aminobutyric acid receptor subunit gamma-30303
Gamma-aminobutyric acid receptor subunit theta0303
Chain A, Dihydrofolate reductase0011
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10303
Alpha-synuclein1102
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30103
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
transcriptional regulator ERG isoform 31001
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0202
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 431001
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10404
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid type B receptor subunit 10011
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, Estrogen receptor 1 (alpha)0101
Chain A, Transthyretin0011
Chain A, Transthyretin0011
BRCA11001
15-lipoxygenase, partial3003
Neuraminidase 0202
Parkin1001
P531001
Alpha-mannosidase0101
pyruvate kinase1001
hexokinase-4 isoform 11001
histone deacetylase 9 isoform 32002
glucokinase regulatory protein1001
glycogen synthase kinase-3 beta isoform 10011
tyrosine-protein kinase Yes1001
pyruvate kinase PKM isoform b1001
Maltase-glucoamylase, intestinal0202
Steroid hormone receptor ERR20101
Tyrosine-protein kinase ABL10101
Pancreatic triacylglycerol lipase0202
Triosephosphate isomerase0101
Cyclin-dependent kinase 10101
Ornithine decarboxylase1001
Sialidase0101
Solute carrier family 2, facilitated glucose transporter member 10101
Tyrosinase0101
Steroid hormone receptor ERR10101
Aromatase0202
Cyclin-dependent kinase 40101
Ornithine decarboxylase0101
Proto-oncogene tyrosine-protein kinase Src0101
Cystic fibrosis transmembrane conductance regulator0011
17-beta-hydroxysteroid dehydrogenase type 10202
Solute carrier family 2, facilitated glucose transporter member 40101
G2/mitotic-specific cyclin-B10101
Protein kinase C alpha type0101
cAMP-dependent protein kinase catalytic subunit alpha0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0202
Amine oxidase [flavin-containing] A 0101
G1/S-specific cyclin-D10101
Thromboxane-A synthase 0101
DNA (cytosine-5)-methyltransferase 10101
Amine oxidase [flavin-containing] B0202
Dipeptidyl peptidase 40303
Proteasome subunit beta type-50202
Adenosine receptor A2a0202
Adenosine receptor A10404
RAC-alpha serine/threonine-protein kinase0101
Cystic fibrosis transmembrane conductance regulator0011
Testosterone 17-beta-dehydrogenase 30101
17-beta-hydroxysteroid dehydrogenase type 20202
Acetylcholinesterase0101
Alpha-glucosidase MAL320101
Signal transducer and activator of transcription 30101
Tyrosine-protein kinase CSK0101
Tyrosine-protein kinase ABL20101
Tyrosine-protein kinase SYK0101
Dual specificity mitogen-activated protein kinase kinase 40101
Quinone oxidoreductase0001
Xanthine dehydrogenase/oxidase0303
Cytoplasmic tyrosine-protein kinase BMX0101
Death-associated protein kinase 10101
Mitogen-activated protein kinase 100101
Oxysterols receptor LXR-beta0101
Amine oxidase [flavin-containing] B0101
Xanthine dehydrogenase/oxidase0101
MO15-related protein kinase Pfmrk 0101
Aldehyde oxidase0101
Oxysterols receptor LXR-alpha0101
Tissue alpha-L-fucosidase0101
Substance-K receptor0202
Integrase 0202
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0101
Prenyltransferase homolog0002
Carboxylic ester hydrolase 0101
Dipeptidyl peptidase 30101
DNA (cytosine-5)-methyltransferase 3-like0101
Sialidase-20101
DNA (cytosine-5)-methyltransferase 3A0101
Glucagon-like peptide 1 receptor0011
Glucagon-like peptide 1 receptor0112
Glucagon receptor0011
Glucagon receptor0011
Glycogen phosphorylase, muscle form0101
Asialoglycoprotein receptor 10112
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0022
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
Neutral amino acid transporter A0202
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0202
Amino acid transporter0202
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10202
Serine racemase0101
Sodium- and chloride-dependent glycine transporter 20101
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
ClpP1001
Solute carrier family 22 member 80001
Carbonic anhydrase 40303
Carbonic anhydrase0202
Carbonic anhydrase 150202
NEDD8-activating enzyme E1 regulatory subunit isoform a0101
NEDD8-conjugating enzyme Ubc120101
Queuine tRNA-ribosyltransferase0101
Dihydrofolate reductase0101
Multidrug and toxin extrusion protein 10202
galanin receptor type 30101
Cytochrome P450 2B60101
Mu-type opioid receptor0203
Delta-type opioid receptor0102
Kappa-type opioid receptor0102
Mas-related G-protein coupled receptor member X20011
Aldehyde oxidase 1 0101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Stromelysin-10101
Matrilysin0101
Multidrug transporter MdfA0101
Matrix metalloproteinase-90101
Protein mono-ADP-ribosyltransferase PARP150101
Protein-arginine deiminase type-40202
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Nuclear receptor corepressor 20101
Chain A, Hth-type Transcriptional Regulator Ttgr0011
Chain A, Hth-type Transcriptional Regulator Ttgr0011
Chain A, Transthyretin0011
Chain A, Transthyretin0011
Chain A, Transthyretin0011
Chain A, Transthyretin0011
Chain B, Transthyretin0011
Chain A, Transthyretin0011
Chain B, Transthyretin0011
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Acetylcholinesterase0404
Carbonic anhydrase 120101
Cytochrome P450 1A10101
Cytochrome P450 1A20101
Carbonyl reductase [NADPH] 10202
Tyrosine-protein phosphatase non-receptor type 10202
Multidrug resistance-associated protein 1 0101
Receptor-type tyrosine-protein kinase FLT30101
Carbonic anhydrase 70101
Cholinesterase0202
Lactoylglutathione lyase0101
Inositol polyphosphate multikinase0101
Carboxylic ester hydrolase 0101
Inositol hexakisphosphate kinase 20101
Neuromedin-K receptor0011
Substance-K receptor0011
Substance-K receptor0202
Substance-P receptor0202
Neuromedin-K receptor0213
Neuromedin-K receptor0101
Substance-K receptor0101
Substance-K receptor0101
Neuropeptide Y receptor type 10202
Neuropeptide Y receptor type 20202
Amyloid-beta precursor protein0202
Cholesteryl ester transfer protein0101
D-amino-acid oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Chain A, Fatty acid-binding protein, adipocyte0101
nuclear receptor subfamily 1, group I, member 21001
Toll-like receptor 20101
Transient receptor potential cation channel subfamily V member 20101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Sphingosine kinase 20202
Sphingosine kinase 10101
Met repressor 0022
Protein arginine N-methyltransferase 50011
Histone H3K27 methylase0001
Phenylethanolamine N-methyltransferase0012
S-adenosylmethionine decarboxylase proenzyme0102
Protein-L-isoaspartate(D-aspartate) O-methyltransferase0101
Catechol O-methyltransferase0001
Protein arginine N-methyltransferase 10101
Methylosome protein 500011
Pyruvate kinase PKM0011
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Carbonic anhydrase 90112
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Carbonic anhydrase 60101
Transketolase0011
Thiamine-binding periplasmic protein0011
1-deoxy-D-xylulose-5-phosphate synthase0011
1-deoxy-D-xylulose-5-phosphate synthase0011
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose0101
Trehalose-phosphatase0101
Thyroid hormone receptor beta0101
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Urease subunit alpha0101
Urease subunit beta0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 22 member 60001
Solute carrier family 22 member 80101
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]