ascorbic-acid and Obsessive-Compulsive-Disorder

Obsessive-compulsive disorder (OCD) is a chronic, prevalent, and highly impairing psychiatric illness. Although the pathophysiology of OCD remains unknown, pathways involved in oxidative and nitrosative stress (O&NS) have been implicated. The present study aims to systematically review the literature for quantitative evidence that patients with OCD have altered measures of blood O&NS markers.. Independent random-effects meta-analyses using standardized mean differences were conducted to assess each marker separately. Additionally, data from multiple markers were pooled together in a meta-analysis for measures of oxidant activity and another for measures of antioxidant activity.. Thirteen studies met inclusion criteria, involving 433 OCD patients and 459 controls. Eleven blood O&NS markers were eligible for independent quantitative analyses. We found that, in OCD patients, the oxidant markers 8-hydroxydeoxyguanosine and malondialdehyde, and the antioxidants glutathione peroxidase and superoxide dismutase, were significantly increased while total antioxidant status, vitamin C, and vitamin E were significantly decreased, when comparing with controls. Regarding pooled meta-analyses, we found a statistically significant increase in oxidant markers, but non-significant results regarding antioxidant markers.. Our meta-analysis suggests that OCD patients have a systemic oxidative imbalance that is not adequately buffered by the antioxidant system. Additional studies are needed in order to support this association.

Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Ascorbic Acid; Biomarkers; Case-Control Studies; Child; Evaluation Studies as Topic; Female; Glutathione Peroxidase; Humans; Male; Malondialdehyde; Middle Aged; Nitrosative Stress; Obsessive-Compulsive Disorder; Oxidative Stress; Superoxide Dismutase; Vitamin E; Young Adult

Topics: Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Female; Humans; Obsessive-Compulsive Disorder; Psychotic Disorders

Free radicals and oxidative stress are involved in the pathogenesis of various diseases. Malondialdehyde (MDA) is a natural product of lipid peroxidation in all mammalian cells. Vitamins C and E are nonenzymatic antioxidant structures. Our study investigated the role of free radicals in the obsessive-compulsive disorder (OCD). The participants were 30 patients with OCD that were drug-free at least for a month and a control group of 30 healthy subjects, matched with respect to age and sex. In both groups, the levels of erythrocyte malondialdehyde and the plasma vitamin C and E concentrations were measured. The levels of malondialdehyde were significantly higher in the patient group than in the control group (p<.01). The levels of plasma vitamin E were significantly lower in the patient than in the control group (p<.02). Although our patient group had slightly lower concentrations of plasma vitamin C compared to our control group, the difference between these two groups was not statistically significant. There was a significant correlation between increasing malondialdehyde levels and decreasing vitamin E concentrations. This study shows the presence of a significant relationship of OCD and oxidative stress, and consequently, an involvement of free radicals and of the antioxidant defence. Biochemical studies may contribute to the understanding of OCD and its treatment.

Topics: Adult; Antioxidants; Ascorbic Acid; Female; Free Radicals; Humans; Male; Malondialdehyde; Obsessive-Compulsive Disorder; Vitamin E

Topics: Ascorbic Acid; Body Weight; Child, Preschool; Diet Therapy; Humans; Intellectual Disability; Male; Metabolism, Inborn Errors; Nervous System Diseases; Obsessive-Compulsive Disorder; Pedigree; Self Mutilation; Uric Acid

Topics: Ascorbic Acid; Compulsive Behavior; Humans; Neurotic Disorders; Obsessive-Compulsive Disorder; Vitamins