An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of prostaglandin-E2 9-reductase (EC 1.1.1.189).
ChEBI ID: 77119
| Member | Definition | Class |
|---|---|---|
| palmitic acid | A straight-chain, sixteen-carbon, saturated long-chain fatty acid. | hexadecanoic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,193 (17.95) | 18.7374 |
| 1990's | 1,346 (20.25) | 18.2507 |
| 2000's | 1,487 (22.37) | 29.6817 |
| 2010's | 1,938 (29.16) | 24.3611 |
| 2020's | 682 (10.26) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 159 (2.34%) | 5.53% |
| Reviews | 171 (2.52%) | 6.00% |
| Case Studies | 18 (0.26%) | 4.05% |
| Observational | 2 (0.03%) | 0.25% |
| Other | 6,444 (94.85%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 90.3068 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 1.0668 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 77.7421 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 43.6486 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 10.7718 | 6 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 22.7590 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 0.0014 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 26.6086 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 34.3762 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 26.4010 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 48.5577 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 2.5575 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 69.6340 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 33.4915 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 62.1624 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 29.2184 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 10.1500 | 1 | 1 |
| Chain A, Fatty acid-binding protein, adipocyte | Homo sapiens (human) | Ki | 0.8020 | 1 | 1 |
| Fatty acid-binding protein 5 | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| Fatty acid-binding protein 5 | Homo sapiens (human) | Ki | 1.3055 | 2 | 4 |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | IC50 | 0.9300 | 1 | 1 |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | Ki | 0.3360 | 1 | 1 |
| Fatty acid-binding protein, intestinal | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 500.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 500.0000 | 1 | 1 |
| Toll-like receptor 2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 8.8000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Fatty acid-binding protein 5 | Homo sapiens (human) | Kd | 0.8020 | 1 | 1 |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | Kd | 83.0000 | 1 | 1 |
| Olfactory receptor 51E2 | Homo sapiens (human) | EC50 | 0.0098 | 1 | 1 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | EC50 | 35.0000 | 1 | 1 |