Roles > opioid receptor agonist
Page last updated: 2024-08-05 15:31:22

opioid receptor agonist

An agent that selectively binds to and activates an opioid receptor.

ChEBI ID: 60606

Members (3)

MemberDefinitionClass
anileridineA piperidinecarboxylate ester that is the ethyl ester of isonipecotic acid in which the hydrogen alpha- to the carboxyl group is substituted by a phenyl group, and the hydrogen attached to the nitrogen is substituted by a 2-(4-aminophenyl)ethyl group.anileridine
codeineA morphinane alkaloid found in the opium poppy, Papaver somniferum var. album; has analgesic, anti-tussive and anti-diarrhoeal properties.codeine
etorphineetorphine

Research

Studies (4,446)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19902,154 (48.45)18.7374
1990's651 (14.64)18.2507
2000's609 (13.70)29.6817
2010's781 (17.57)24.3611
2020's251 (5.65)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials730 (14.97%)5.53%
Reviews248 (5.08%)6.00%
Case Studies357 (7.32%)4.05%
Observational20 (0.41%)0.25%
Other3,523 (72.22%)84.16%

Protein Targets (32)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency61.441511
cytochrome P450 2C9, partialHomo sapiens (human)Potency27.540411
cytochrome P450 2D6Homo sapiens (human)Potency1.737711
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency30.835622
GVesicular stomatitis virusPotency27.540411
GALC proteinHomo sapiens (human)Potency0.707911
GLI family zinc finger 3Homo sapiens (human)Potency17.316622
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency27.540411
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency27.540412
Interferon betaHomo sapiens (human)Potency27.540411
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency29.656222
pregnane X nuclear receptorHomo sapiens (human)Potency3.757811
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency36.632522

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Cytochrome P450 2D1Rattus norvegicus (Norway rat)IC501,320.000011
Cytochrome P450 2D26Rattus norvegicus (Norway rat)IC50238.000011
Cytochrome P450 2D3Rattus norvegicus (Norway rat)IC504,089.000011
Cytochrome P450 2D4Rattus norvegicus (Norway rat)IC502,216.000011
Cytochrome P450 2D6Homo sapiens (human)IC50171.000022
Delta-type opioid receptorHomo sapiens (human)IC509.300011
Delta-type opioid receptorMus musculus (house mouse)IC5010.000013
Delta-type opioid receptorRattus norvegicus (Norway rat)IC500.007412
Delta-type opioid receptorHomo sapiens (human)Ki52.207011
Delta-type opioid receptorMus musculus (house mouse)Ki0.002922
Delta-type opioid receptorRattus norvegicus (Norway rat)Ki0.000311
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)IC500.001811
Kappa-type opioid receptorHomo sapiens (human)IC5015.000011
Kappa-type opioid receptorMus musculus (house mouse)IC5010.000013
Kappa-type opioid receptorHomo sapiens (human)Ki8.470733
Kappa-type opioid receptorRattus norvegicus (Norway rat)Ki0.000211
Mu-type opioid receptorHomo sapiens (human)IC500.105011
Mu-type opioid receptorMus musculus (house mouse)IC5010.000013
Mu-type opioid receptorRattus norvegicus (Norway rat)IC500.000111
Mu-type opioid receptorHomo sapiens (human)Ki3.513522
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki0.200245
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC50301.995011
Solute carrier family 22 member 1 Homo sapiens (human)IC50235.500011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Mas-related G-protein coupled receptor member X2Homo sapiens (human)EC508.400022
Mu-type opioid receptorHomo sapiens (human)EC506.100011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Delta-type opioid receptorRattus norvegicus (Norway rat)Activity0.040011
UDP-glucuronosyltransferase 2B7Homo sapiens (human)Km1,100.000012