Any EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor that interferes with the action of quercetin 2,3-dioxygenase (EC 1.13.1.24).
ChEBI ID: 85051
| Member | Definition | Class | Studies | Trials |
|---|---|---|---|---|
| kojic acid | A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae. | enol; | 1,938 | 30 | |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 1.9724 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 21.3138 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.1366 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Tyrosinase | Priestia megaterium | IC50 | 52.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 63.2557 | 107 | 108 |
| Polyphenol oxidase 2 | Agaricus bisporus | Ki | 82.3278 | 9 | 9 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 2.0000 | 1 | 1 |
| Polymerase acidic protein | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 12.4446 | 1 | 2 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 716.9000 | 3 | 3 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 5,500.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 1,014.7415 | 19 | 20 |
| Tyrosinase | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 12.4446 | 1 | 2 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 8.3300 | 1 | 1 |
| Uncharacterized protein YOR062C | Saccharomyces cerevisiae S288C | IC50 | 19.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Polyphenol oxidase 1 | Agaricus bisporus | IC50 | 20.1350 | 2 | 2 |
| Polyphenol oxidase 1 | Agaricus bisporus | Ki | 12.2000 | 1 | 1 |
| Tyrosinase | Danio rerio (zebrafish) | IC50 | 12,550.0000 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Tyrosinase | Priestia megaterium | Kd | 377.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Tyrosinase | Homo sapiens (human) | Km | 79.0000 | 4 | 4 |
| Studies | Pre-1990 | 1990's | 2000's | 2010's | Post-2020 |
|---|---|---|---|---|---|
| 622 | 34 | 59 | 160 | 309 | 60 |