Roles > carotenoid biosynthesis inhibitor
Page last updated: 2024-08-05 15:00:58

carotenoid biosynthesis inhibitor

Any pathway inhibitor that acts on the carotenoid biosynthesis pathway.

ChEBI ID: 138208

Members (10)

MemberDefinitionClass
aclonifenA primary amino compound that is aniline in which the phenyl group has been substituted at positions 2, 3, and 6 by chlorine, phenoxy, and nitro groups, respectively. A protoporphyrinogen oxidase (PPO) inhibitor, it is used as a herbicide against a broad range of weeds in a wide range of crops.aclonifen
amitroleA member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.amitrole
clomazoneAn isoxazolidinone that is 1,2-oxazolidin-3-one substituted by a 2-chlorobenzyl group at position 2 and two methyl groups at position 4.clomazone
diflufenicanA pyridinecarboxamide that is pyridine-3-carboxamide substituted by a 2,4-difluorophenyl group at the carbamoyl nitrogen and a 3-(trifluoromethyl)phenoxy group at position 2.diflufenican
fluridoneFluridone
mesotrioneAn aromatic ketone that is cyclohexa-1,3-dione in which one of the hydrogens at position 2 is substituted by a 4-(methanesulfonyl)-2-nitrobenzoyl group.mesotrione
norflurazoneA pyridazinone that is pyridazin-3(2H)-one which is substituted at positions 2, 4, and 5 by m-(trifluoromethyl)phenyl, chloro, and methylamino groups, respectively. A pre-emergence herbicide used to control grasses and broad-leafed weeds in a variety of crops. Not approved for use within the European Union.norflurazon
raiserflurochloridone
sulcotrioneAn aromatic ketone that is cyclohexane-1,3-dione substituted by a 2-chloro-4-(methylsulfonyl)benzoyl group at position 2.sulcotrione
tembotrioneAn aromatic ketone that is 2-benzoylcyclohexane-1,3-dione in which the phenyl group is substituted at positions 2, 3, and 4 by chlorine, (2,2,2-trifluoroethoxy)methyl, and methylsulfonyl groups, respectively. It is a post-emergence herbicide used (particularly in conjunction with the herbicide safener cyprosulfamide) for the control of a wide range of broad-leaved and grassy weeds in corn and other crops.tembotrione

Research

Studies (1,401)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990340 (24.27)18.7374
1990's265 (18.92)18.2507
2000's337 (24.05)29.6817
2010's350 (24.98)24.3611
2020's109 (7.78)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials4 (0.26%)5.53%
Reviews17 (1.12%)6.00%
Case Studies6 (0.39%)4.05%
Observational0 (0.00%)0.25%
Other1,495 (98.23%)84.16%

Protein Targets (70)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency34.764236
AR proteinHomo sapiens (human)Potency29.64521026
aryl hydrocarbon receptorHomo sapiens (human)Potency23.803339
Ataxin-2Homo sapiens (human)Potency56.961413
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency56.011425
Cellular tumor antigen p53Homo sapiens (human)Potency69.777111
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency33.997212
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency39.810711
ClpPBacillus subtilisPotency35.481311
cytochrome P450 2C9, partialHomo sapiens (human)Potency18.149811
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency15.848922
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency23.974113
DNA polymerase kappa isoform 1Homo sapiens (human)Potency37.685811
estrogen nuclear receptor alphaHomo sapiens (human)Potency25.05581027
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency64.554012
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency24.4855626
GVesicular stomatitis virusPotency18.149811
GABA theta subunitRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency15.848911
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency15.848911
GLI family zinc finger 3Homo sapiens (human)Potency26.3867310
glp-1 receptor, partialHomo sapiens (human)Potency0.501211
GLS proteinHomo sapiens (human)Potency70.794611
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency22.269111
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency6.268713
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.118711
histone deacetylase 9 isoform 3Homo sapiens (human)Potency30.859123
Histone H2A.xCricetulus griseus (Chinese hamster)Potency87.833212
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency18.149811
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency18.149812
Interferon betaHomo sapiens (human)Potency18.149811
LuciferasePhotinus pyralis (common eastern firefly)Potency47.849613
neuropeptide S receptor isoform AHomo sapiens (human)Potency10.000011
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency45.718649
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency24.986311
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency22.4710317
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency47.551513
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency15.124733
pregnane X nuclear receptorHomo sapiens (human)Potency31.5152212
pregnane X receptorRattus norvegicus (Norway rat)Potency15.848911
progesterone receptorHomo sapiens (human)Potency45.113325
RAR-related orphan receptor gammaMus musculus (house mouse)Potency18.347928
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency26.7923313
retinoid X nuclear receptor alphaHomo sapiens (human)Potency21.2958311
SMAD family member 2Homo sapiens (human)Potency55.937311
SMAD family member 3Homo sapiens (human)Potency55.937311
TDP1 proteinHomo sapiens (human)Potency21.776423
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency60.969526
thyroid stimulating hormone receptorHomo sapiens (human)Potency22.995323
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency4.864911
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency27.903423
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency17.596344
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency6.268713

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-cis-phytoene desaturaseSynechococcus elongatus PCC 7942 = FACHB-805IC500.285013
4-hydroxyphenylpyruvate dioxygenaseArabidopsis thaliana (thale cress)IC500.250011
4-hydroxyphenylpyruvate dioxygenaseArabidopsis thaliana (thale cress)Ki0.013022
Integrase Human immunodeficiency virus 1IC500.170011
Zeta-carotene desaturase, chloroplastic/chromoplasticCapsicum annuumIC50100.000012
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