Any pathway inhibitor that acts on the carotenoid biosynthesis pathway.
| Member | Definition | Class |
|---|
| aclonifen | A primary amino compound that is aniline in which the phenyl group has been substituted at positions 2, 3, and 6 by chlorine, phenoxy, and nitro groups, respectively. A protoporphyrinogen oxidase (PPO) inhibitor, it is used as a herbicide against a broad range of weeds in a wide range of crops. | aclonifen |
| amitrole | A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties. | amitrole |
| clomazone | An isoxazolidinone that is 1,2-oxazolidin-3-one substituted by a 2-chlorobenzyl group at position 2 and two methyl groups at position 4. | clomazone |
| diflufenican | A pyridinecarboxamide that is pyridine-3-carboxamide substituted by a 2,4-difluorophenyl group at the carbamoyl nitrogen and a 3-(trifluoromethyl)phenoxy group at position 2. | diflufenican |
| fluridone | | Fluridone |
| mesotrione | An aromatic ketone that is cyclohexa-1,3-dione in which one of the hydrogens at position 2 is substituted by a 4-(methanesulfonyl)-2-nitrobenzoyl group. | mesotrione |
| norflurazone | A pyridazinone that is pyridazin-3(2H)-one which is substituted at positions 2, 4, and 5 by m-(trifluoromethyl)phenyl, chloro, and methylamino groups, respectively. A pre-emergence herbicide used to control grasses and broad-leafed weeds in a variety of crops. Not approved for use within the European Union. | norflurazon |
| raiser | | flurochloridone |
| sulcotrione | An aromatic ketone that is cyclohexane-1,3-dione substituted by a 2-chloro-4-(methylsulfonyl)benzoyl group at position 2. | sulcotrione |
| tembotrione | An aromatic ketone that is 2-benzoylcyclohexane-1,3-dione in which the phenyl group is substituted at positions 2, 3, and 4 by chlorine, (2,2,2-trifluoroethoxy)methyl, and methylsulfonyl groups, respectively. It is a post-emergence herbicide used (particularly in conjunction with the herbicide safener cyprosulfamide) for the control of a wide range of broad-leaved and grassy weeds in corn and other crops. | tembotrione |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 34.7642 | 3 | 6 |
| AR protein | Homo sapiens (human) | Potency | 29.6452 | 10 | 26 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 23.8033 | 3 | 9 |
| Ataxin-2 | Homo sapiens (human) | Potency | 56.9614 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 56.0114 | 2 | 5 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 69.7771 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| ClpP | Bacillus subtilis | Potency | 35.4813 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 18.1498 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.9741 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.0558 | 10 | 27 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 64.5540 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 24.4855 | 6 | 26 |
| G | Vesicular stomatitis virus | Potency | 18.1498 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 26.3867 | 3 | 10 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 0.5012 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 22.2691 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 6.2687 | 1 | 3 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 30.8591 | 2 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 87.8332 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 18.1498 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 18.1498 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 18.1498 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 47.8496 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 45.7186 | 4 | 9 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 24.9863 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 22.4710 | 3 | 17 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 47.5515 | 1 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 15.1247 | 3 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 31.5152 | 2 | 12 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 45.1133 | 2 | 5 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 18.3479 | 2 | 8 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 26.7923 | 3 | 13 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 21.2958 | 3 | 11 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 55.9373 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 55.9373 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 21.7764 | 2 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 60.9695 | 2 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 22.9953 | 2 | 3 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 4.8649 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 27.9034 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 17.5963 | 4 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 6.2687 | 1 | 3 |