null
ChEBI ID: 50844
| Member | Definition | Class |
|---|---|---|
| drospirenone | drospirenone | |
| eplerenone | eplerenone | |
| spironolactone | A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. | spironolactone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,719 (36.38) | 18.7374 |
| 1990's | 566 (7.57) | 18.2507 |
| 2000's | 1,665 (22.28) | 29.6817 |
| 2010's | 1,943 (26.00) | 24.3611 |
| 2020's | 580 (7.76) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,309 (14.90%) | 5.53% |
| Reviews | 1,046 (11.90%) | 6.00% |
| Case Studies | 605 (6.88%) | 4.05% |
| Observational | 37 (0.42%) | 0.25% |
| Other | 5,791 (65.90%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 28.1838 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 48.9662 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 8.3692 | 12 | 32 |
| Ataxin-2 | Homo sapiens (human) | Potency | 16.4761 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 28.3216 | 2 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 20.3422 | 2 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 31.5127 | 1 | 3 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 4.8207 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 18.1925 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.6753 | 7 | 13 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 30.6379 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 23.7435 | 6 | 12 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 10.9781 | 4 | 4 |
| G | Vesicular stomatitis virus | Potency | 23.9185 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.0328 | 2 | 4 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.3750 | 3 | 6 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 30.6379 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 126.7930 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 23.9185 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 21.9905 | 3 | 5 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 32.3511 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 30.8994 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 48.2660 | 2 | 2 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 23.3848 | 5 | 7 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 25.5131 | 5 | 6 |
| PPM1D protein | Homo sapiens (human) | Potency | 20.8212 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 36.7262 | 3 | 3 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 14.3250 | 3 | 5 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 16.7392 | 2 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 34.9861 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 9.4520 | 4 | 5 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 16.1373 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 16.1373 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 7.6425 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 26.6550 | 2 | 6 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 17.4015 | 5 | 6 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 30.6379 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 3.1623 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | IC50 | 6.2865 | 6 | 11 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.4060 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | Ki | 0.0394 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0906 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 23.6000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 74.7000 | 1 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Chain A, Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 0.0490 | 1 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 13.9255 | 2 | 4 |
| Estrogen receptor | Homo sapiens (human) | Ki | 1.1000 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 52.0000 | 3 | 5 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 12.3458 | 5 | 9 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 1.3532 | 3 | 3 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 1.9025 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 0.8648 | 1 | 1 |
| Mineralocorticoid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0398 | 1 | 1 |
| Mineralocorticoid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0444 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | IC50 | 0.3827 | 18 | 29 |
| Mineralocorticoid receptor | Homo sapiens (human) | Ki | 0.0444 | 2 | 3 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 85.4500 | 1 | 2 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 7.6700 | 5 | 10 |
| Progesterone receptor | Homo sapiens (human) | Ki | 10.1762 | 2 | 2 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 7.9300 | 1 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Rattus norvegicus (Norway rat) | IC50 | 5.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC50 | 20.0000 | 1 | 2 |
| Estrogen receptor | Homo sapiens (human) | EC50 | 20.0000 | 1 | 2 |
| Estrogen receptor beta | Homo sapiens (human) | EC50 | 11.6500 | 1 | 2 |
| Glucocorticoid receptor | Homo sapiens (human) | EC50 | 20.0000 | 1 | 2 |
| Mineralocorticoid receptor | Homo sapiens (human) | EC50 | 0.1000 | 1 | 1 |
| Progesterone receptor | Homo sapiens (human) | EC50 | 20.0000 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Rattus norvegicus (Norway rat) | Anogenital distance | 1,460.0000 | 1 | 1 |
| Mineralocorticoid receptor | Homo sapiens (human) | Kb | 0.0177 | 1 | 1 |