An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of myosin-light-chain kinase (EC 2.7.11.18).
ChEBI ID: 78763
| Member | Definition | Class |
|---|---|---|
| chrysin | A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. | chrysin |
| kt 5926 | An organic heterooctacyclic compound that is 5-propoxy-1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of methyl (3R)-3-hydroxy-2-methyltetrahydrofuran-3-carboxylate (the 2S,3R,5R product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol-2-one. | KT 5926 |
| ml 7 | An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18). | ML-7 |
| sterogenol | A pyridinium salt that has N-hexadecylpyridinium as the cation and bromide as the anion. | cetylpyridinium bromide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 10 (0.84) | 18.7374 |
| 1990's | 102 (8.52) | 18.2507 |
| 2000's | 290 (24.23) | 29.6817 |
| 2010's | 570 (47.62) | 24.3611 |
| 2020's | 225 (18.80) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 6 (0.48%) | 5.53% |
| Reviews | 48 (3.84%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,196 (95.68%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 10.8820 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 17.3311 | 2 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 41.1126 | 3 | 9 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 48.9187 | 2 | 4 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 11.0323 | 1 | 4 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 16.9366 | 10 | 33 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 19.4597 | 3 | 4 |
| arylsulfatase A | Homo sapiens (human) | Potency | 11.9955 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 8.9700 | 2 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 8.9340 | 2 | 6 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| BRCA1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 69.6773 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 69.6773 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 45.2659 | 2 | 7 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 23.6125 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 6.6918 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 0.0977 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 11.2947 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 6.5517 | 2 | 8 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 30.9008 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 12.2538 | 1 | 4 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 16.3374 | 3 | 3 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 26.1216 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.9106 | 12 | 41 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 53.6272 | 3 | 8 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 8.4433 | 6 | 24 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 30.0365 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 31.2932 | 3 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 42.1774 | 5 | 11 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 20.8954 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 38.9018 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 6.5517 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 19.8687 | 2 | 5 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 19.4705 | 3 | 9 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 18.4938 | 2 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 35.5080 | 4 | 11 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 12.4869 | 1 | 4 |
| Glycoprotein hormones alpha chain | Homo sapiens (human) | Potency | 1.0000 | 1 | 2 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 44.4306 | 2 | 6 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 5.0119 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 8.8648 | 2 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 45.3267 | 2 | 7 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 20.9126 | 3 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 8.1995 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 38.9018 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 24.8492 | 3 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 17.3926 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 36.2124 | 2 | 3 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 20.7310 | 2 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 2.2387 | 2 | 2 |
| Nrf2 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.4441 | 4 | 12 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 53.3522 | 2 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 1.1883 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.4957 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 7.9433 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 43.3616 | 3 | 10 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 2.5119 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.3806 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 44.6413 | 4 | 12 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 50.3351 | 5 | 11 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 50.1187 | 1 | 1 |
| polyprotein | Zika virus | Potency | 20.8954 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 28.1838 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 17.0390 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 18.5569 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.2084 | 2 | 4 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 58.4824 | 2 | 6 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 3.9203 | 2 | 8 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 35.6956 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 15.6410 | 3 | 12 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 22.8800 | 4 | 10 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 22.3072 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 16.8678 | 2 | 7 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 16.8678 | 2 | 7 |
| Smad3 | Homo sapiens (human) | Potency | 31.8326 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.1623 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 19.4783 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.4031 | 2 | 13 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 37.6858 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 16.9494 | 3 | 9 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 44.6684 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 17.5061 | 4 | 5 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 34.8917 | 2 | 4 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 42.3564 | 2 | 6 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 32.4825 | 5 | 12 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 12.4869 | 1 | 4 |
| Vpr | Human immunodeficiency virus 1 | Potency | 15.8489 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 2.8310 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 1.6180 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 2.8310 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 1.6180 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 3.1730 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.9070 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 5.6900 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 3.6210 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 1.2880 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.6740 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 1.2880 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.6740 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 2.7530 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 4.7580 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 2.6890 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 7.7900 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 8.1400 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.6530 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.6310 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.7580 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.6890 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.7580 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 2.6890 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.2420 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0910 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 1.7780 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.8120 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 1.4970 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.2170 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 0.6670 | 3 | 3 |
| Aromatase | Homo sapiens (human) | Ki | 2.6000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 33.4300 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 6.9700 | 3 | 3 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 6.0216 | 3 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 6.2300 | 3 | 3 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 0.5377 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.1714 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 2.6800 | 2 | 2 |
| Carbonyl reductase [NADPH] 1 | Homo sapiens (human) | IC50 | 0.6700 | 1 | 1 |
| Carbonyl reductase [NADPH] 1 | Homo sapiens (human) | Ki | 0.1100 | 1 | 1 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Chain A, Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | Ki | 19.0100 | 1 | 2 |
| Cyclin homolog | Herpesvirus saimiri (strain 11) | IC50 | 5.8500 | 1 | 4 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 7.1000 | 1 | 1 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 | 5.8500 | 1 | 4 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 5.3000 | 2 | 5 |
| Cyclin-dependent kinase 6 | Homo sapiens (human) | IC50 | 5.8800 | 2 | 5 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 5.3000 | 2 | 5 |
| cysteine protease ATG4B isoform a | Homo sapiens (human) | IC50 | 7.1400 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 0.7215 | 2 | 2 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.0420 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.2360 | 3 | 3 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.1520 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0160 | 2 | 2 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Cytochrome P450 2B6 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 5.2250 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Dipeptidyl peptidase 3 | Homo sapiens (human) | IC50 | 123.1000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 3.4720 | 1 | 1 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 | 5.8500 | 1 | 4 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 7.1000 | 1 | 1 |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | IC50 | 7.1000 | 1 | 1 |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | IC50 | 7.1000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 0.9200 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 3.0200 | 1 | 1 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 5.8500 | 1 | 4 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 13.8000 | 3 | 3 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 83.1764 | 1 | 1 |
| Melanocortin receptor 4 | Homo sapiens (human) | IC50 | 5.0810 | 1 | 1 |
| Melanocortin receptor 4 | Homo sapiens (human) | Ki | 4.8860 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | IC50 | 3.7260 | 1 | 1 |
| Melanocortin receptor 5 | Homo sapiens (human) | Ki | 3.4950 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 25.8500 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 25.8500 | 1 | 2 |
| MO15-related protein kinase Pfmrk | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 500.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.0330 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0079 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.1160 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.0410 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.0340 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0073 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.1060 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0150 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0073 | 1 | 1 |
| Myosin light chain kinase, smooth muscle | Homo sapiens (human) | Ki | 0.3000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 43.9867 | 3 | 3 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 67.6350 | 1 | 1 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | IC50 | 25.5000 | 1 | 1 |
| phospholipase A2 precursor | Homo sapiens (human) | IC50 | 8.3400 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 39.3000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 25.5000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 5.5000 | 2 | 2 |
| putative polyprotein | IC50 | 13.7115 | 2 | 2 | |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 61.0900 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 1.8780 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Rho-associated protein kinase 1 | Homo sapiens (human) | IC50 | 38.0000 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Ki | 19.4000 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 890.0000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 6.2790 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 4.9890 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.6530 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.6310 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.6800 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.8920 | 1 | 1 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.6350 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 45.7000 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 8.6320 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | Ki | 2.8770 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 45.7000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 6.4520 | 1 | 1 |
| Triosephosphate isomerase | Oryctolagus cuniculus (rabbit) | Ki | 2.6000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 0.2980 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 3.1820 | 1 | 1 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 302.0000 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 302.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 1.2600 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 0.8400 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Kd | 8.9125 | 1 | 1 |
| Chain A, Transthyretin | Homo sapiens (human) | Kd | 1.4000 | 1 | 5 |
| Chain B, Transthyretin | Homo sapiens (human) | Kd | 1.4000 | 1 | 2 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 300.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Androgen receptor | Homo sapiens (human) | EC150 | 1.5000 | 1 | 1 |
| DNA repair protein RAD52 homolog isoform a | Homo sapiens (human) | AC50 | 3.7900 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | EC150 | 1.5000 | 1 | 1 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 4.0320 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 4.2200 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Km | 62.9900 | 2 | 2 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | Vmax | 0.0055 | 2 | 2 |