angiogenesis modulating agent

An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.

ChEBI ID: 50926

Members (16)

Member	Definition	Class
2-methoxyestradiol	A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.	2-methoxy-17beta-estradiol
5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one	A homoisoflavonoid that is 2,3-dihydro-4H-chromen-4-onethat is substituted by hydroxy groups at positions 5 and 7, a methoxy group at position 6, and a 3-hydroxy-4-methoxybenzyl group at position 3. It has been isolated from various plants, including the bulb of Cremastra appendiculata.	cremastranone
alpha-glutamyltryptophan	A dipeptide composed of L-glutamic acid and L-tryptophan joined by a peptide linkage.	Glu-Trp
asiatic acid	A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). It is isolated from Symplocos lancifolia and Vateria indica and exhibits anti-angiogenic activity.	asiatic acid
cigb-300	A synthetic 25-membered heterodetic cyclic peptide consisting of a 14-membered linear component attached to an 11-membered cyclic portion. A CK2 inhibitor with potential antineoplastic activity.	CIGB-300
ecteinascidin 743	A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.	trabectedin
ginsenoside rg3	A ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position.	(20S)-ginsenoside Rg3
hydrazinocurcumin	A pyrazole obtained by cyclocodensation of the two carbonyl groups of curcumin with hydrazine.	hydrazinocurcumin
morin	A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.	morin
oltipraz	A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.	oltipraz
panobinostat	A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.	panobinostat
pazopanib	A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.	pazopanib
proanthocyanidin a2	A proanthocyanidin obtained by the condensation of (-)-epicatechin units.	proanthocyanidin A2
salvin	An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity.	carnosic acid
sc 560	A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-methoxyphenyl, trifluoromethyl and 4-chlorophenyl groups, respectively. Unlike many members of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors, SC-560 is selective for COX-1.	SC560
semaxinib	An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.	semaxanib

Research

Studies (6,049)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	93 (1.54)	18.7374
1990's	284 (4.69)	18.2507
2000's	1,469 (24.29)	29.6817
2010's	3,241 (53.58)	24.3611
2020's	962 (15.90)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	531 (8.36%)	5.53%
Reviews	589 (9.28%)	6.00%
Case Studies	291 (4.58%)	4.05%
Observational	30 (0.47%)	0.25%
Other	4,909 (77.31%)	84.16%

Protein Targets (788)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	27.6510	1	3
15-lipoxygenase, partial	Homo sapiens (human)	Potency	15.8489	1	1
acetylcholinesterase	Homo sapiens (human)	Potency	24.7604	3	3
activating transcription factor 6	Homo sapiens (human)	Potency	13.2532	2	2
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	17.0390	1	2
AR protein	Homo sapiens (human)	Potency	10.1681	8	22
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	0.6799	2	5
ATAD5 protein, partial	Homo sapiens (human)	Potency	11.5774	1	1
Ataxin-2	Homo sapiens (human)	Potency	4.3280	1	2
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	12.5049	2	3
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	6.2828	2	3
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	5.8479	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	16.8828	2	6
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	50.1187	1	1
C-terminal-binding protein 1	Homo sapiens (human)	Potency	16.9469	1	1
caspase-1 isoform alpha precursor	Homo sapiens (human)	Potency	39.8107	1	1
Caspase-7	Homo sapiens (human)	Potency	15.8489	1	1
Cellular tumor antigen p53	Homo sapiens (human)	Potency	9.3225	2	7
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	3.9811	1	1
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	32.1487	1	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	21.3544	2	5
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	50.1187	1	1
Chain A, Cruzipain	Trypanosoma cruzi	Potency	19.9526	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	38.1519	2	3
Chain A, HADH2 protein	Homo sapiens (human)	Potency	11.7262	2	3
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	8.9125	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	6.5194	2	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	9.9763	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	3.2546	1	2
Chain B, HADH2 protein	Homo sapiens (human)	Potency	11.7262	2	3
chromobox protein homolog 1	Homo sapiens (human)	Potency	35.9041	1	3
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	7.9433	1	1
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	17.5594	1	2
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	16.3924	1	3
cytochrome P450 2D6	Homo sapiens (human)	Potency	38.9018	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	35.7168	2	4
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	3.1208	2	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	3.1725	1	3
D(1A) dopamine receptor	Homo sapiens (human)	Potency	7.9760	2	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	Homo sapiens (human)	Potency	15.7686	3	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	11.3012	3	4
DNA polymerase beta	Homo sapiens (human)	Potency	2.5146	1	2
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	7.9433	1	1
DNA polymerase III, partial	Bacillus subtilis	Potency	18.8876	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	39.3376	1	4
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	8.5612	1	4
endonuclease IV	Escherichia coli	Potency	14.3335	1	2
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	6.6197	8	26
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	30.6085	3	4
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	18.0771	9	10
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	18.8328	2	9
EWS/FLI fusion protein	Homo sapiens (human)	Potency	19.9970	3	3
eyes absent homolog 2 isoform a	Homo sapiens (human)	Potency	43.9632	2	2
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	32.2632	3	4
flap endonuclease 1	Homo sapiens (human)	Potency	10.9798	2	3
Fumarate hydratase	Homo sapiens (human)	Potency	33.1734	1	1
G	Vesicular stomatitis virus	Potency	16.3924	1	3
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	35.7168	1	2
geminin	Homo sapiens (human)	Potency	6.9622	3	4
GLI family zinc finger 3	Homo sapiens (human)	Potency	1.3118	2	4
glp-1 receptor, partial	Homo sapiens (human)	Potency	8.1968	2	2
GLS protein	Homo sapiens (human)	Potency	2.2016	1	2
glucocerebrosidase	Homo sapiens (human)	Potency	39.8107	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	22.7657	3	8
glucokinase regulatory protein	Homo sapiens (human)	Potency	10.0000	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	9.4392	1	1
GTP-binding nuclear protein Ran isoform 1	Homo sapiens (human)	Potency	17.7828	1	1
hexokinase-4 isoform 1	Homo sapiens (human)	Potency	10.0000	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	13.2583	2	8
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	15.8489	1	1
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	26.6032	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	34.6344	1	4
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	16.3924	1	3
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	26.8325	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	5.0119	2	2
IDH1	Homo sapiens (human)	Potency	2.5524	1	2
importin subunit beta-1 isoform 1	Homo sapiens (human)	Potency	15.9541	2	2
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	16.3924	1	6
Interferon beta	Homo sapiens (human)	Potency	11.2787	3	17
lamin isoform A-delta10	Homo sapiens (human)	Potency	14.4326	1	2
Luciferase	Photinus pyralis (common eastern firefly)	Potency	19.8049	1	2
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	21.3346	1	2
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	31.2951	1	4
Microtubule-associated protein tau	Homo sapiens (human)	Potency	10.5345	2	8
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	14.1254	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	7.8087	2	3
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	22.3872	1	1
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	11.2947	1	2
NFKB1 protein, partial	Homo sapiens (human)	Potency	10.0000	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	10.4304	1	2
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	16.3601	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	10.9337	2	3
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	14.8981	1	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	26.8325	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	25.6651	2	2
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	0.6310	1	1
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	8.4876	3	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	23.4862	2	3
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	18.1056	1	1
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	59.3646	1	2
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	10.2873	3	7
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	25.3135	3	4
phosphoglycerate kinase	Trypanosoma brucei brucei TREU927	Potency	23.9341	1	1
phosphopantetheinyl transferase	Bacillus subtilis	Potency	45.5756	2	4
plasminogen precursor	Mus musculus (house mouse)	Potency	2.0812	1	2
polyprotein	Zika virus	Potency	33.1734	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	1.9953	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	0.3548	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	16.9618	1	4
PPM1D protein	Homo sapiens (human)	Potency	5.6539	1	8
pregnane X nuclear receptor	Homo sapiens (human)	Potency	15.4220	2	2
progesterone receptor	Homo sapiens (human)	Potency	30.0474	1	2
pyruvate kinase	Leishmania mexicana mexicana	Potency	19.9526	2	2
Rap guanine nucleotide exchange factor 3	Homo sapiens (human)	Potency	15.8489	1	1
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	84.2180	2	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	7.7140	2	3
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	13.2043	1	3
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	16.4512	2	2
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	3.1391	2	3
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	23.7781	1	1
SMAD family member 2	Homo sapiens (human)	Potency	16.9301	1	1
SMAD family member 3	Homo sapiens (human)	Potency	16.9301	1	1
Smad3	Homo sapiens (human)	Potency	15.8489	1	1
snurportin-1	Homo sapiens (human)	Potency	15.9541	2	2
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	19.9740	1	2
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	14.9763	1	2
TDP1 protein	Homo sapiens (human)	Potency	3.2516	2	10
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	28.6300	2	8
Thrombopoietin	Homo sapiens (human)	Potency	4.0871	2	4
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	3.2346	3	10
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	19.9526	2	2
thyrotropin-releasing hormone receptor	Homo sapiens (human)	Potency	16.9330	1	1
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	55.0000	2	2
transient receptor potential cation channel subfamily V member 1	Homo sapiens (human)	Potency	17.7828	1	1
tumor susceptibility gene 101 protein	Homo sapiens (human)	Potency	42.8000	2	2
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	0.8404	1	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	Homo sapiens (human)	Potency	17.4872	1	2
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	2.0812	1	2
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	2.0812	1	2
USP1 protein, partial	Homo sapiens (human)	Potency	24.6514	2	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	26.0334	3	3
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	19.9526	1	1
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	9.4392	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1,25-dihydroxyvitamin D-3 receptor	Sus scrofa domesticus (domestic pig)	IC50	1.0400	1	1
10 kDa chaperonin	Escherichia coli	IC50	6.8500	2	2
10 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	11.0000	1	1
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	2.3000	1	1
60 kDa chaperonin	Escherichia coli K-12	IC50	250.0000	1	1
60 kDa chaperonin	Escherichia coli	IC50	6.8500	2	2
60 kDa heat shock protein, mitochondrial	Homo sapiens (human)	IC50	11.0000	1	1
Acetylcholinesterase	Homo sapiens (human)	IC50	0.9300	1	1
Adenosine receptor A3	Homo sapiens (human)	Ki	34.0000	1	1
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	IC50	117.0000	2	2
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	IC50	5.9000	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	IC50	1.5050	2	2
Alpha-synuclein	Homo sapiens (human)	IC50	126.8000	1	1
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	14.6627	6	6
Angiopoietin-1 receptor	Homo sapiens (human)	IC50	10.0000	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	1
Aurora kinase B	Homo sapiens (human)	IC50	4.7100	1	1
B-cell CLL/lymphoma 9 protein	Homo sapiens (human)	IC50	5.2130	1	1
B-cell CLL/lymphoma 9 protein	Homo sapiens (human)	Ki	4.8780	3	3
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	8.0000	1	1
Beta-secretase 1	Homo sapiens (human)	IC50	12.3000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	10.3000	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	35.0000	2	2
Bromodomain-containing protein 4	Homo sapiens (human)	IC50	0.0050	1	1
Cadherin-1	Homo sapiens (human)	Ki	387.2000	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	IC50	3.6450	4	4
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	1
Carbonic anhydrase 1	Homo sapiens (human)	IC50	100.0000	2	4
Carbonic anhydrase 1	Homo sapiens (human)	Ki	13.5500	1	4
Carbonic anhydrase 2	Homo sapiens (human)	IC50	100.0000	2	4
Carbonic anhydrase 2	Homo sapiens (human)	Ki	13.5500	1	4
Carbonic anhydrase 3	Bos taurus (cattle)	Ki	13.5500	1	4
Carbonic anhydrase 4	Bos taurus (cattle)	IC50	100.0000	2	4
Carbonic anhydrase 4	Homo sapiens (human)	Ki	13.5500	1	4
Carbonic anhydrase 9	Homo sapiens (human)	IC50	100.0000	2	2
Carbonic anhydrase 9	Homo sapiens (human)	Ki	0.0091	1	1
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	10.0000	2	2
Casein kinase II subunit alpha 3	Homo sapiens (human)	IC50	10.0000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	10.0000	2	2
Casein kinase II subunit beta	Homo sapiens (human)	IC50	10.0000	2	2
Catenin beta-1	Homo sapiens (human)	IC50	5.2130	1	1
Catenin beta-1	Homo sapiens (human)	Ki	4.8780	3	3
Cationic trypsin	Bos taurus (cattle)	IC50	110.8000	1	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	Homo sapiens (human)	IC50	0.1700	1	3
Class A sortase SrtA	Staphylococcus aureus	IC50	31.2600	3	3
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	10.0000	1	1
Cytochrome P450 1A1	Homo sapiens (human)	Ki	62.0000	2	2
Cytochrome P450 1A2	Homo sapiens (human)	Ki	9.0000	1	1
Cytochrome P450 1B1	Homo sapiens (human)	Ki	36.0000	1	1
Cytochrome P450 2C9	Homo sapiens (human)	Ki	9.2000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	0.0300	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	0.0300	1	1
Cytochrome P450 3A4	Homo sapiens (human)	Ki	4.3000	1	1
Cytochrome P450 3A5	Homo sapiens (human)	IC50	0.0033	1	1
Death-associated protein kinase 1	Homo sapiens (human)	IC50	6.3000	2	2
Dihydrofolate reductase	Homo sapiens (human)	IC50	2.4000	1	1
Dihydrofolate reductase	Mus musculus (house mouse)	IC50	2.4000	1	1
Dihydrofolate reductase	Pneumocystis carinii	IC50	2.4000	1	1
Dihydrofolate reductase	Rattus norvegicus (Norway rat)	IC50	2.4000	1	1
Dipeptidyl peptidase 3	Homo sapiens (human)	IC50	85.0000	1	1
Discoidin domain-containing receptor 2	Homo sapiens (human)	IC50	0.0505	2	2
DNA repair protein RAD52 homolog	Homo sapiens (human)	IC50	450.0000	2	2
DNA topoisomerase 1	Homo sapiens (human)	IC50	250.0000	1	1
DNA topoisomerase 2-alpha	Homo sapiens (human)	IC50	250.0000	1	1
DNA-3-methyladenine glycosylase	Homo sapiens (human)	IC50	2.6000	1	1
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	5.0000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	49.0295	12	19
estrogen receptor beta isoform 1	Homo sapiens (human)	IC50	2.9272	1	2
Farnesyl pyrophosphate synthase	Homo sapiens (human)	IC50	20.0000	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	26.8181	13	20
Fibroblast growth factor receptor 2	Homo sapiens (human)	IC50	2.5700	2	2
Fibroblast growth factor receptor 3	Homo sapiens (human)	IC50	5.0000	1	1
Fibroblast growth factor receptor 4	Homo sapiens (human)	IC50	5.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	IC50	1.6000	1	1
Glutathione S-transferase omega-1	Homo sapiens (human)	IC50	62.0000	1	1
Glycogen phosphorylase, muscle form	Oryctolagus cuniculus (rabbit)	IC50	16.9941	2	3
Histone deacetylase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	0.0026	2	2
Histone deacetylase 1	Homo sapiens (human)	IC50	0.1810	29	37
Histone deacetylase 1	Homo sapiens (human)	Ki	0.0016	5	5
Histone deacetylase 11	Homo sapiens (human)	IC50	0.8396	10	10
Histone deacetylase 11	Homo sapiens (human)	Ki	0.6018	2	2
Histone deacetylase 2	Homo sapiens (human)	IC50	0.2526	19	27
Histone deacetylase 2	Homo sapiens (human)	Ki	0.0076	5	5
Histone deacetylase 3	Homo sapiens (human)	IC50	0.2031	25	33
Histone deacetylase 3	Homo sapiens (human)	Ki	0.0017	4	4
Histone deacetylase 4	Homo sapiens (human)	IC50	0.7963	16	24
Histone deacetylase 4	Homo sapiens (human)	Ki	0.3821	5	5
Histone deacetylase 5	Homo sapiens (human)	IC50	1.1971	15	23
Histone deacetylase 5	Homo sapiens (human)	Ki	0.0544	4	4
Histone deacetylase 6	Homo sapiens (human)	IC50	0.2307	22	30
Histone deacetylase 6	Homo sapiens (human)	Ki	0.0148	6	6
Histone deacetylase 7	Homo sapiens (human)	IC50	1.8509	13	21
Histone deacetylase 7	Homo sapiens (human)	Ki	2.4331	4	4
Histone deacetylase 8	Homo sapiens (human)	IC50	0.4600	19	27
Histone deacetylase 8	Schistosoma mansoni	IC50	0.4500	1	1
Histone deacetylase 8	Homo sapiens (human)	Ki	0.2304	5	5
Histone deacetylase 9	Homo sapiens (human)	IC50	1.5071	13	21
Histone deacetylase 9	Homo sapiens (human)	Ki	1.8078	4	4
Histone-lysine N-methyltransferase SETD7	Homo sapiens (human)	IC50	6.0200	1	1
Insulin-like growth factor 1 receptor	Homo sapiens (human)	IC50	55.0000	2	2
Integrase	Human immunodeficiency virus 1	IC50	54.1000	2	2
Interstitial collagenase	Homo sapiens (human)	IC50	4.8500	1	1
Islet amyloid polypeptide	Homo sapiens (human)	IC50	7.8000	1	1
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	250.0000	1	1
Lactoylglutathione lyase	Homo sapiens (human)	Ki	30.1995	1	1
Leukotriene A-4 hydrolase	Homo sapiens (human)	IC50	10.0000	2	2
Low molecular weight phosphotyrosine protein phosphatase	Bos taurus (cattle)	IC50	10.0000	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	IC50	0.1680	3	3
Macrophage-stimulating protein receptor	Homo sapiens (human)	IC50	10.0000	1	1
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50	0.2268	6	6
Matrix metalloproteinase-9	Homo sapiens (human)	IC50	19.4000	1	1
Mcl-1	Homo sapiens (human)	IC50	2.9883	1	1
microphthalmia-associated transcription factor isoform 9	Homo sapiens (human)	IC50	6.3810	3	3
Microtubule-associated protein tau	Homo sapiens (human)	IC50	34.0000	1	1
Mitogen-activated protein kinase 10	Homo sapiens (human)	IC50	19.1000	1	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	19.1000	1	2
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	0.2000	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	8.1000	1	1
NAD-dependent protein deacetylase sirtuin-1	Homo sapiens (human)	IC50	20.0000	1	1
NAD-dependent protein deacetylase sirtuin-1	Homo sapiens (human)	Ki	10.0000	1	1
NAD-dependent protein deacetylase sirtuin-2	Homo sapiens (human)	IC50	20.0000	1	1
NAD-dependent protein deacetylase sirtuin-2	Homo sapiens (human)	Ki	10.0000	1	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)	IC50	20.0000	1	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)	Ki	10.0000	1	1
NAD-dependent protein deacetylase sirtuin-7	Homo sapiens (human)	Ki	10.0000	1	1
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.5000	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	0.5000	1	1
Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)	IC50	29.8000	1	1
Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)	IC50	29.8000	1	1
Nuclear receptor corepressor 2	Homo sapiens (human)	IC50	0.0020	6	6
Pancreatic alpha-amylase	Sus scrofa (pig)	IC50	200.0000	1	1
Pancreatic triacylglycerol lipase	Homo sapiens (human)	IC50	36.0000	1	1
Pancreatic triacylglycerol lipase	Sus scrofa (pig)	IC50	100.0000	1	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	Homo sapiens (human)	IC50	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	IC50	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	IC50	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	IC50	10.0000	1	1
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	IC50	0.1355	2	2
Platelet-derived growth factor receptor alpha	Mus musculus (house mouse)	IC50	14.8700	3	3
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	17.9687	19	26
Platelet-derived growth factor receptor beta	Mus musculus (house mouse)	IC50	14.8700	3	3
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	0.0070	10	10
Polyamine deacetylase HDAC10	Homo sapiens (human)	Ki	0.0180	2	2
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	6.8015	6	6
Polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	IC50	7.3000	1	1
Prostaglandin E synthase	Homo sapiens (human)	IC50	5.0000	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	0.0301	8	9
Prostaglandin G/H synthase 1	Ovis aries (sheep)	IC50	4.4693	8	9
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	22.3218	9	9
Prostaglandin G/H synthase 2	Ovis aries (sheep)	IC50	74.9000	1	1
Protease	Human immunodeficiency virus 1	IC50	0.2400	1	1
Protein E6	Human papillomavirus 16	IC50	4.0000	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	IC50	0.1700	1	1
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	22.9543	3	7
Receptor protein-tyrosine kinase	Homo sapiens (human)	IC50	2.2043	1	3
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	100.0000	1	1
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	IC50	0.8730	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	0.1600	1	1
Receptor-type tyrosine-protein phosphatase S	Homo sapiens (human)	IC50	4.3000	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	10.0000	1	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	0.4150	1	2
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	IC50	2.7000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	IC50	12.6000	1	1
Signal transducer and activator of transcription 3	Homo sapiens (human)	IC50	16.2000	1	1
Similar to alpha-tubulin isoform 1	Bos taurus (cattle)	IC50	17.8889	5	9
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50	9.7000	1	1
Solute carrier family 22 member 12	Homo sapiens (human)	IC50	2.0000	1	1
Solute carrier family 22 member 12	Rattus norvegicus (Norway rat)	IC50	18.0000	1	1
Solute carrier family 22 member 12	Homo sapiens (human)	Ki	5.7400	1	1
Sortase A	Streptococcus mutans	IC50	27.2000	1	1
Thiosulfate sulfurtransferase	Homo sapiens (human)	IC50	57.0000	1	1
Transcription factor 7-like 2	Homo sapiens (human)	Ki	387.2000	1	1
Transcription factor p65	Homo sapiens (human)	IC50	29.8000	1	1
Tubulin alpha-1A chain	Sus scrofa (pig)	IC50	21.1000	2	2
Tubulin beta chain	Sus scrofa (pig)	IC50	21.1000	2	2
Tubulin beta-2B chain	Bos taurus (cattle)	IC50	1,786.1750	8	8
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	5.5226	3	5
Tyrosine-protein kinase SYK	Homo sapiens (human)	IC50	28.0000	1	1
Tyrosine-protein kinase Yes	Homo sapiens (human)	Ki	7.9000	1	1
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	IC50	20.7000	1	1
Tyrosine-protein phosphatase non-receptor type 1	Homo sapiens (human)	IC50	20.0000	1	1
Tyrosine-protein phosphatase non-receptor type 2	Homo sapiens (human)	IC50	20.0000	1	1
Vascular endothelial growth factor receptor 1	Mus musculus (house mouse)	IC50	1.0400	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	IC50	0.3984	8	8
Vascular endothelial growth factor receptor 2	Danio rerio (zebrafish)	IC50	0.0680	1	2
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	10.2982	49	58
Vascular endothelial growth factor receptor 2	Mus musculus (house mouse)	IC50	1.0400	1	1
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50	0.1228	6	6
Xanthine dehydrogenase/oxidase	Homo sapiens (human)	IC50	10.1000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	1
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	16.6667	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	2	2
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	1
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	1
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	16.2180	1	1
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	1
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	1
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
Activin receptor type-1	Homo sapiens (human)	Kd	16.6667	3	3
Activin receptor type-1B	Homo sapiens (human)	Kd	16.6667	3	3
Activin receptor type-2A	Homo sapiens (human)	Kd	10.0000	2	2
Activin receptor type-2B	Homo sapiens (human)	Kd	16.2000	3	4
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	2
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	1
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	1	1
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	1
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	2.2000	2	2
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	6.6500	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	2	2
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	16.4500	3	4
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	1
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	1
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	20.0000	3	4
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	10.0000	2	2
Aurora kinase A	Homo sapiens (human)	Kd	11.2910	4	4
Aurora kinase B	Homo sapiens (human)	Kd	16.6667	3	3
Aurora kinase C	Homo sapiens (human)	Kd	0.7500	2	2
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	2	2
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	15.8667	3	3
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	16.6667	3	3
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	15.5000	2	2
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	16.6667	3	3
Breakpoint cluster region protein	Homo sapiens (human)	Kd	30.0000	1	1
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	0.3700	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	16.6667	3	3
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	2.1000	2	2
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	3.7000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	16.6667	3	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	16.6667	3	3
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	16.6667	3	3
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	16.6667	3	3
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	16.6667	3	3
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	2	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	1
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	23.3333	2	3
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase I isoform delta	Homo sapiens (human)	Kd	16.6667	3	3
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	16.6667	3	3
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	16.6667	3	3
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	16.6667	3	3
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	16.6667	3	3
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	2	2
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	16.6667	3	3
Catenin beta-1	Homo sapiens (human)	Kd	20.0000	1	1
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	1
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	1
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	1.3000	2	2
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	2.1000	2	2
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	20.0000	2	2
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	10.8000	3	3
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	10.0000	2	2
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	10.0000	1	1
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	16.6667	3	3
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	10.1333	3	3
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	1
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	2	2
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	1
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	3	3
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	1
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	1
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	0.1755	6	6
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	1
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	1
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	1
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	1
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	16.6667	3	3
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	16.6667	3	3
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	10.3933	3	3
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	15.2400	2	2
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	12.7333	3	3
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	1
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	16.6667	3	3
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	16.6667	3	3
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	10.1000	3	3
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	20.0000	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	10.0000	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	10.0000	2	2
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	1
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	10.0000	2	2
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	16.6667	3	3
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	15.0405	2	2
Epidermal growth factor receptor	Homo sapiens (human)	Kd	10.8696	23	23
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	0.0820	3	3
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	20.0000	2	2
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	1
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	10.6600	3	3
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	0.2100	2	2
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	0.6800	4	4
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	2.8000	2	2
Focal adhesion kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
G-protein coupled bile acid receptor 1	Homo sapiens (human)	EC50	10.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	6.2650	2	2
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	1
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	1
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	16.6667	3	3
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	16.6667	3	3
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	1
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	1
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	9.5000	5	5
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	16.6667	3	3
Histone deacetylase 1	Homo sapiens (human)	EC50	0.1695	1	1
Histone deacetylase 2	Homo sapiens (human)	EC50	0.1695	1	1
Histone deacetylase 3	Homo sapiens (human)	EC50	0.1695	1	1
Histone deacetylase 6	Homo sapiens (human)	EC50	0.1507	1	1
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	16.6667	3	3
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	1
Insulin receptor	Homo sapiens (human)	Kd	16.6667	3	3
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	2	2
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	20.0000	3	4
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	1.9000	2	2
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	17.9500	2	2
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	9.0603	3	3
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	20.0000	2	2
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	8.4000	2	2
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	10.0000	1	1
LIM domain kinase 1	Homo sapiens (human)	Kd	1.2490	3	3
LIM domain kinase 2	Homo sapiens (human)	Kd	5.4687	3	3
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	0.0079	2	2
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	20.0000	2	2
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	16.6667	3	3
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	16.6667	3	3
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	12.6667	3	3
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	16.6667	3	3
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	0.1747	15	15
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	20.0000	3	4
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	16.6667	3	3
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	1
Midasin	Homo sapiens (human)	Kd	30.0000	1	1
Misshapen-like kinase 1	Homo sapiens (human)	Kd	20.0000	2	2
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	11.2667	3	3
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	20.0000	3	4
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	2	2
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	14.0000	3	3
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	16.4500	2	2
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	2.1000	2	2
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	1.0328	4	4
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	0.9400	1	1
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	15.1450	2	2
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	20.0000	2	2
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	16.6667	3	3
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	20.0000	2	2
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	1
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	0.2900	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	10.5000	3	3
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	16.3500	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	11.0667	3	3
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	14.0667	3	3
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	12.0000	3	3
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	1
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	1
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	2.0000	2	2
Myosin light chain kinase 3	Homo sapiens (human)	Kd	20.0000	2	2
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	2	2
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	16.6667	3	3
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	1
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	2	2
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	2	2
Myotonin-protein kinase	Homo sapiens (human)	Kd	10.0000	2	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	1
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	13.6600	3	3
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	13.3500	4	4
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	2	2
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	20.0000	3	4
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	1
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	1
oxytocin receptor	Homo sapiens (human)	EC50	11.4680	1	1
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	10.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	1
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	1
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	0.9600	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	1.9000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	12	12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	15.1400	2	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	16.6667	3	3
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	10.0000	2	2
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	0.0049	2	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	0.1447	3	3
POsterior Segregation	Caenorhabditis elegans	EC50	300.0000	1	1
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	2
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	1
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	2
Protein kinase C delta type	Homo sapiens (human)	EC50	14.9700	1	1
Protein kinase C delta type	Homo sapiens (human)	Kd	16.6667	3	3
Protein kinase C epsilon type	Homo sapiens (human)	EC50	18.8100	1	1
Protein kinase C epsilon type	Homo sapiens (human)	Kd	10.0000	2	2
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	2	2
Protein kinase C iota type	Homo sapiens (human)	Kd	20.0000	2	2
Protein kinase C theta type	Homo sapiens (human)	EC50	7.2500	1	1
Protein kinase C theta type	Homo sapiens (human)	Kd	16.6667	3	3
Protein Tat	HIV-1 M:B_HXB2R	EC50	0.1300	1	1
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	16.6667	3	3
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	16.1500	3	4
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	1.3789	7	7
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	0.9200	2	2
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	11.8667	3	3
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	1
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	1
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	1
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	16.6667	3	3
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	16.6667	3	3
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	16.6667	3	3
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	0.9000	2	2
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	1
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	1
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	10.0000	2	2
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	10.0000	1	1
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	10.0000	1	1
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	0.2600	2	2
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	2.9417	3	3
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	1.8560	1	1
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	1
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	2.7682	14	14
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	20.0000	2	2
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	20.0000	2	2
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	10.0000	1	1
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	10.0000	1	1
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	14.0000	5	5
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	4	4
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	16.6667	3	3
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	14.0000	5	5
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	14.0000	5	5
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	14.0000	5	5
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	20.0000	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	30.0000	1	1
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	1
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	1
Septin-9	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	10.0560	3	3
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	10.2400	3	3
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	0.4700	2	2
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	6.4640	5	5
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	1
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	10.6533	3	3
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	8.6500	2	2
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	12.9333	3	3
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	16.6667	3	3
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	10.1933	3	3
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	0.6100	1	1
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	2.2000	2	2
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	14.8667	3	3
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	20.0000	3	4
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	15.1200	2	2
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	15.9000	2	2
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	20.0150	2	3
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	2	2
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	10.0000	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	20.0000	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	1
Sex hormone-binding globulin	Homo sapiens (human)	Kd	0.0008	1	1
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	1
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	EC50	300.0000	1	1
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	2
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	1
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	13.4133	3	3
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	1
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	1
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	2	2
TGF-beta receptor type-1	Homo sapiens (human)	Kd	16.6667	3	3
TGF-beta receptor type-2	Homo sapiens (human)	Kd	14.3333	3	3
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	10.2067	3	3
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	1
Tubulin alpha-1A chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	10.0000	1	1
Tubulin alpha-1B chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin alpha-1C chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin alpha-3C chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin alpha-3E chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin alpha-4A chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-1 chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-2A chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-2B chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-3 chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-4A chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-4B chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-6 chain	Homo sapiens (human)	Kd	149.7630	1	2
Tubulin beta-8 chain	Homo sapiens (human)	Kd	149.7630	1	2
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	5.3630	23	23
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	12.0000	3	3
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	2.6000	2	2
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	16.6667	3	3
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	16.6667	3	3
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	16.3500	3	4
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	13.8000	3	3
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	1.6000	2	2
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	10.5000	3	3
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	11.8000	3	3
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	15.2333	3	3
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	15.0000	4	4
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	5.8500	2	2
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	6.9000	2	2
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	10.8000	3	3
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	10.6633	3	3
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	12.2000	3	3
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	0.7000	2	2
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	10.0000	2	2
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	2.5000	2	2
Tyrosine-protein kinase SYK	Homo sapiens (human)	EC50	300.0000	1	1
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	14.9000	3	3
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	16.6667	3	3
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	2.6000	2	2
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	13.3333	3	3
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	1
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	1
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	1
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	0.0140	2	2
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	0.0140	2	2
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	0.0270	2	2
vasopressin V1a receptor	Homo sapiens (human)	EC50	12.0700	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Wee1-like protein kinase	Homo sapiens (human)	Kd	16.6667	3	3
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	1
Zinc finger protein mex-5	Caenorhabditis elegans	EC50	300.0000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Amyloid-beta precursor protein	Homo sapiens (human)	DC50	1.4700	1	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	Homo sapiens (human)	AC50	10.8400	1	1
glycogen synthase kinase-3 alpha	Homo sapiens (human)	AC50	300.0000	1	1
interferon gamma precursor	Homo sapiens (human)	AC50	5.8000	2	4
Lactoperoxidase	Bos taurus (cattle)	Km	12.6600	1	1
Microtubule-associated protein tau	Homo sapiens (human)	DC50	17.0000	1	1
Nuclear factor erythroid 2-related factor 2	Mus musculus (house mouse)	CD	10.2000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	ED50	0.9300	1	1