ascorbic-acid and 3--4--5--trimethoxyflavone

Flavones are valuable scaffolds in medicinal chemistry, especially as they display activity as antioxidants and neuroprotective agents. The need to incorporate a fluorine atom on flavones has driven much of the recent synthetic work in this area. We now report a route for the production of 3-fluorinated derivatives of 3',4',5'-trihydroxyflavone and 3',4',5'-trimethoxyflavone. Biological evaluation of these agents, along with their non-fluorinated counterparts, demonstrate that antioxidant activity may be enhanced whereas neuroprotective activity is conserved. Also, the 3-fluoro-3',4',5'-trihydroxyflavone can act as an NMR probe to detect structural changes during its action as a radical scavenger.

Topics: Animals; Antioxidants; Cell Survival; Flavones; Flavonoids; Halogenation; Magnetic Resonance Spectroscopy; Neurons; Neuroprotective Agents; Neurotoxins; Rats; Reactive Oxygen Species; Structure-Activity Relationship