Roles > EC 2.7.11.10 (IkappaB kinase) inhibitor
Page last updated: 2024-08-05 15:13:25

EC 2.7.11.10 (IkappaB kinase) inhibitor

An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of IkappaB kinase (EC 2.7.11.10).

ChEBI ID: 77113

Members (3)

MemberDefinitionClass
bay 11-7082A nitrile that is acrylonitrile in which the hydrogen located beta,trans to the cyano group is replaced by a tosyl group. It is an inhibitor of cytokine-induced IkappaB-alpha phosphorylation in cells.(E)-3-tosylacrylonitrile
bay 11-7085A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB.BAY11-7085
berberineberberine

Research

Studies (4,679)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990219 (4.68)18.7374
1990's262 (5.60)18.2507
2000's825 (17.63)29.6817
2010's2,265 (48.41)24.3611
2020's1,108 (23.68)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials103 (2.15%)5.53%
Reviews307 (6.39%)6.00%
Case Studies8 (0.17%)4.05%
Observational1 (0.02%)0.25%
Other4,382 (91.27%)84.16%

Protein Targets (95)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency10.000011
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency11.225024
Alpha-synucleinHomo sapiens (human)Potency7.670113
Amyloid-beta precursor proteinHomo sapiens (human)Potency1.734612
arylsulfatase AHomo sapiens (human)Potency7.568611
ATAD5 protein, partialHomo sapiens (human)Potency26.957724
Ataxin-2Homo sapiens (human)Potency22.740612
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency20.473012
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency11.995511
atrial natriuretic peptide receptor 2 precursorHomo sapiens (human)Potency8.315212
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.005622
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency9.647513
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency17.393114
chromobox protein homolog 1Homo sapiens (human)Potency42.239512
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency2.511911
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency12.589322
D(1A) dopamine receptorHomo sapiens (human)Potency8.779023
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency17.873947
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency1.193914
EWS/FLI fusion proteinHomo sapiens (human)Potency8.357244
flap endonuclease 1Homo sapiens (human)Potency89.125111
Fumarate hydrataseHomo sapiens (human)Potency34.712013
GABA theta subunitRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency12.589311
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency12.589311
gemininHomo sapiens (human)Potency1.122011
GLS proteinHomo sapiens (human)Potency9.834412
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency2.930923
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency21.479614
hypothetical protein, conservedTrypanosoma bruceiPotency12.718112
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency2.511922
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency10.430422
Interferon betaHomo sapiens (human)Potency10.435313
lamin isoform A-delta10Homo sapiens (human)Potency7.191222
M-phase phosphoprotein 8Homo sapiens (human)Potency19.952611
Microtubule-associated protein tauHomo sapiens (human)Potency7.739013
neuropeptide S receptor isoform AHomo sapiens (human)Potency19.952611
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency3.548111
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency94.449512
Nrf2Homo sapiens (human)Potency11.582111
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency0.842222
ParkinHomo sapiens (human)Potency29.092912
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency6.242622
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency8.492111
phosphopantetheinyl transferaseBacillus subtilisPotency2.528612
polyproteinZika virusPotency34.712013
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency35.481311
PPM1D proteinHomo sapiens (human)Potency10.435312
ras-related protein Rab-9AHomo sapiens (human)Potency58.047913
regulator of G-protein signaling 4Homo sapiens (human)Potency2.700113
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency0.521211
Smad3Homo sapiens (human)Potency15.848911
survival motor neuron protein isoform dHomo sapiens (human)Potency21.280412
TDP1 proteinHomo sapiens (human)Potency0.826824
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.968436
thyroid stimulating hormone receptorHomo sapiens (human)Potency12.589311
transient receptor potential cation channel subfamily V member 1Homo sapiens (human)Potency11.220211
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency6.578914

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseElectrophorus electricus (electric eel)IC500.782733
AcetylcholinesteraseHomo sapiens (human)IC500.400022
Aldo-keto reductase family 1 member C2 Homo sapiens (human)IC506.710011
Aldo-keto reductase family 1 member C3Homo sapiens (human)IC504.990022
C-C chemokine receptor type 2Homo sapiens (human)IC504.177011
C-C chemokine receptor type 2Homo sapiens (human)Ki1.614011
CholinesteraseEquus caballus (horse)IC5015.266733
CholinesteraseHomo sapiens (human)IC5015.895022
Class A sortase SrtA Staphylococcus aureusIC50129.000011
Cytochrome P450 1B1Homo sapiens (human)IC500.974733
Cytochrome P450 1B1Homo sapiens (human)Ki0.044011
D(1A) dopamine receptorHomo sapiens (human)IC504.412011
D(1A) dopamine receptorHomo sapiens (human)Ki2.206011
D(3) dopamine receptorHomo sapiens (human)IC503.460011
D(3) dopamine receptorHomo sapiens (human)Ki1.175011
Lysine-specific histone demethylase 1AHomo sapiens (human)IC506.970011
NACHT, LRR and PYD domains-containing protein 3 Mus musculus (house mouse)IC5012.000011
NeuraminidaseInfluenza A virus (A/USSR/90/1977(H1N1))IC5035.350022
NeuraminidaseInfluenza A virus (A/Puerto Rico/8/1934(H1N1))Ki14.300011
Nuclear factor NF-kappa-B p100 subunit Homo sapiens (human)IC502.000011
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)IC502.000011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC5066.069311
Prolyl endopeptidaseHomo sapiens (human)IC50143.500022
Replicase polyprotein 1abBetacoronavirus England 1IC5010.000012
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC500.830012
Telomerase reverse transcriptaseHomo sapiens (human)IC5037.000011
Transcription factor p65Homo sapiens (human)IC502.500022
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC5067.000011
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