An antagonist that blocks glycine receptors.
ChEBI ID: 62754
| Member | Definition | Class |
|---|---|---|
| kavain | DL-kavain | |
| strychnine | A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position. | strychnine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,495 (56.31) | 18.7374 |
| 1990's | 728 (16.43) | 18.2507 |
| 2000's | 660 (14.90) | 29.6817 |
| 2010's | 464 (10.47) | 24.3611 |
| 2020's | 84 (1.90) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 16 (0.33%) | 5.53% |
| Reviews | 112 (2.34%) | 6.00% |
| Case Studies | 97 (2.03%) | 4.05% |
| Observational | 1 (0.02%) | 0.25% |
| Other | 4,563 (95.28%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 5.3538 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 19.0919 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 0.1843 | 14 | 20 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | Ki | 0.0503 | 3 | 3 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0120 | 1 | 1 |
| Glycine receptor subunit beta | Homo sapiens (human) | IC50 | 0.2871 | 6 | 9 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Taste receptor type 2 member 10 | Homo sapiens (human) | EC50 | 22.5000 | 2 | 2 |
| Taste receptor type 2 member 46 | Homo sapiens (human) | EC50 | 0.6900 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit rho-1 | Homo sapiens (human) | Kb | 69.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit rho-2 | Homo sapiens (human) | Kb | 69.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit rho-3 | Homo sapiens (human) | Kb | 69.0000 | 1 | 1 |
| Taste receptor type 2 member 10 | Homo sapiens (human) | Activity | 1.5500 | 2 | 2 |