Classes > statin (naturally occurring)
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statin (naturally occurring)
Any statin that occurs in nature. The class includes compactin (also known as mevastatin), isolated from a fermentation broth of Penicillium citrinum, and lovastatin, isolated from Aspergillus terreus.
ChEBI ID: 87632
Members (2)
| Member | Definition | Role |
|---|
| lovastatin | A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). | lovastatin |
| mevastatin | A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals. | mevastatin |
Research
Studies (4,614)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|
| pre-1990 | 452 (9.80) | 18.7374 |
| 1990's | 1,938 (42.00) | 18.2507 |
| 2000's | 1,238 (26.83) | 29.6817 |
| 2010's | 804 (17.43) | 24.3611 |
| 2020's | 182 (3.94) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|
| Trials | 701 (13.17%) | 5.53% |
| Reviews | 385 (7.23%) | 6.00% |
| Case Studies | 234 (4.40%) | 4.05% |
| Observational | 2 (0.04%) | 0.25% |
| Other | 4,001 (75.16%) | 84.16% |