ascorbic-acid and tyloxapol

The inhibition of lipoprotein catabolism after triton WR-1339 intravenous administration is associated with an impressive modification in the balance between plasma peroxidable substrates and antioxidants. Treated rat plasma and membrane lipids become peroxiaable when they are incubated with phenylhydrazine in standardized conditions and the production of thiobarbituric acid-reactive substances (lipoperoxidation markers) significantly increases. An accumulation of native lipoproteins which present a decreased alpha-tocopherol on triglycerid ratio and a modification in the plasmatic balance between alpha-tocopherol and ascorbate could explain these observations.

Topics: Animals; Ascorbic Acid; Disease Models, Animal; Erythrocytes; Fatty Acids; Humans; Hyperlipidemias; In Vitro Techniques; Lipid Peroxidation; Lipids; Male; Polyethylene Glycols; Rats; Rats, Wistar; Surface-Active Agents; Vitamin E

We report an impressive decline in plasma lipid resistance to oxidation during Triton-WR-1339-induced hyperlipidemia in rats. This decline is associated with a modification in the balances between alpha-tocopherol and lipids and alpha-tocopherol and ascorbate. These results are consistent with a weak resistance of accumulated native lipoproteins in plasma to oxidation, during a 6-hour time course, and they suggest a misunderstood role of lipoprotein catabolic enzymes: to improve this characteristic. Conclusively, the results lead us to propound Triton-induced hyperlipidemia as an original model for studying the balance impairment between antioxidants and oxidizable substrates.

Topics: Animals; Ascorbic Acid; Fatty Acids; Hyperlipidemias; Lipids; Lipoproteins; Male; Oxidation-Reduction; Polyethylene Glycols; Rats; Rats, Wistar; Surface-Active Agents; Vitamin E