| Member | Definition | Class |
|---|
| antimycin a | A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison. | antimycin A |
| azides | | azide anion |
| carbon monoxide | A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas. | carbon monoxide |
| diuron | A member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group. | diuron |
| ilicicolin h | An aromatic ketone in which the ketone carbonyl group is attached to a (1R,2R,4aS,7S,8aR)-4,7-dimethyl-1-[(1E)-prop-1-en-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-yl group and a 4-hydroxy-5-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridin-3-yl group. Isolated from the from the "imperfect" fungus Cylindrocladium iliciola strain MFC-870. | ilicicolin H |
| piericidin a | A member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductase | piericidin A |
| sodium azide | The sodium salt of hydrogen azide (hydrazoic acid). | sodium azide |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 43.3248 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 28.7968 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 28.0173 | 9 | 14 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 41.1688 | 3 | 7 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 0.0200 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 25.7877 | 2 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 38.4531 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 0.2239 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 44.0350 | 9 | 13 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 36.2428 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 58.6614 | 4 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0706 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 36.4261 | 2 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 2.9566 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 6.3096 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 38.5963 | 2 | 3 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 5.2300 | 1 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 56.3386 | 4 | 6 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 0.0531 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 44.6684 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 38.3909 | 3 | 13 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 25.0625 | 2 | 2 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 0.0726 | 2 | 2 |
| polyprotein | Zika virus | Potency | 2.9566 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 5.2300 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 77.1579 | 1 | 3 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 0.0501 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 60.9441 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 25.2768 | 2 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 12.2893 | 2 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 1.3817 | 2 | 3 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 27.3060 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.2512 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 42.0830 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Acyl carrier protein, mitochondrial | Bos taurus (cattle) | IC50 | 0.0050 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 52.3000 | 2 | 2 |
| Carbonic anhydrase | Methanosarcina thermophila | Ki | 6,525.0000 | 4 | 4 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 27,800.0000 | 1 | 1 |
| Carbonic anhydrase | Pseudomonas aeruginosa PAO1 | Ki | 770.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 4,164.0062 | 13 | 16 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 16,652.4250 | 1 | 4 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 3,835.7577 | 23 | 26 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 26,341.9400 | 2 | 5 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 10.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase (fumarate) | Saccharomyces cerevisiae S288C | IC50 | 10.0000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 23,000.6000 | 2 | 2 |
| Laccase | Trametes versicolor | IC50 | 266.3333 | 3 | 3 |
| Mitochondrial succinate dehydrogenase subunit C | Zymoseptoria tritici | IC50 | 15.0010 | 2 | 2 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 2.1160 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 1,510.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | Bos taurus (cattle) | IC50 | 0.0050 | 1 | 1 |
| NADH-ubiquinone oxidoreductase chain 1 | Bos taurus (cattle) | IC50 | 0.0045 | 2 | 2 |
| Photosystem II protein D1 | Spinacia oleracea (spinach) | IC50 | 1.0849 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 2.2000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 3.8200 | 1 | 1 |
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | Zymoseptoria tritici | IC50 | 15.0010 | 2 | 2 |