Roles > mitochondrial respiratory-chain inhibitor
Page last updated: 2024-08-05 14:39:31

mitochondrial respiratory-chain inhibitor

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ChEBI ID: 25355

Members (7)

MemberDefinitionClass
antimycin aA nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison.antimycin A
azidesazide anion
carbon monoxideA one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.carbon monoxide
diuronA member of the class of 3-(3,4-substituted-phenyl)-1,1-dimethylureas that is urea in which both of the hydrogens attached to one nitrogen are substituted by methyl groups, and one of the hydrogens attached to the other nitrogen is substituted by a 3,4-dichlorophenyl group.diuron
ilicicolin hAn aromatic ketone in which the ketone carbonyl group is attached to a (1R,2R,4aS,7S,8aR)-4,7-dimethyl-1-[(1E)-prop-1-en-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-yl group and a 4-hydroxy-5-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridin-3-yl group. Isolated from the from the "imperfect" fungus Cylindrocladium iliciola strain MFC-870.ilicicolin H
piericidin aA member of the class of monohydroxypyridines that acts as an irreversible mitochondrial Complex I inhibitor that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of NADH:ubiquinone oxidoreductasepiericidin A
sodium azideThe sodium salt of hydrogen azide (hydrazoic acid).sodium azide

Research

Studies (31,279)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199010,805 (34.54)18.7374
1990's4,193 (13.41)18.2507
2000's6,335 (20.25)29.6817
2010's8,028 (25.67)24.3611
2020's1,918 (6.13)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials701 (2.07%)5.53%
Reviews1,637 (4.84%)6.00%
Case Studies242 (0.72%)4.05%
Observational74 (0.22%)0.25%
Other31,138 (92.15%)84.16%

Protein Targets (91)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency35.481311
acetylcholinesteraseHomo sapiens (human)Potency43.324811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency28.796812
AR proteinHomo sapiens (human)Potency28.0173914
aryl hydrocarbon receptorHomo sapiens (human)Potency41.168837
Cellular tumor antigen p53Homo sapiens (human)Potency0.020011
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency12.589311
Chain A, HADH2 proteinHomo sapiens (human)Potency31.622811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency25.787722
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency25.118912
Chain B, HADH2 proteinHomo sapiens (human)Potency31.622811
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency6.309622
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency38.453111
endonuclease IVEscherichia coliPotency0.223911
estrogen nuclear receptor alphaHomo sapiens (human)Potency44.0350913
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency36.242822
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency58.661446
EWS/FLI fusion proteinHomo sapiens (human)Potency0.070644
farnesoid X nuclear receptorHomo sapiens (human)Potency36.426122
Fumarate hydrataseHomo sapiens (human)Potency2.956611
GABA theta subunitRattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency6.309611
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency6.309611
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency22.387211
Glutamate receptor 1Rattus norvegicus (Norway rat)Potency31.622811
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency38.596323
Glutamate receptor 3Rattus norvegicus (Norway rat)Potency31.622811
Glutamate receptor 4Rattus norvegicus (Norway rat)Potency31.622811
Interferon betaHomo sapiens (human)Potency5.230013
mitogen-activated protein kinase 1Homo sapiens (human)Potency1.000011
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency56.338646
Nuclear receptor ROR-gammaHomo sapiens (human)Potency0.053111
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency44.668411
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency38.3909313
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency25.062522
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency35.481311
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency0.072622
polyproteinZika virusPotency2.956611
PPM1D proteinHomo sapiens (human)Potency5.230012
pregnane X nuclear receptorHomo sapiens (human)Potency77.157913
pregnane X receptorRattus norvegicus (Norway rat)Potency0.050111
progesterone receptorHomo sapiens (human)Potency60.944111
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency25.276824
retinoid X nuclear receptor alphaHomo sapiens (human)Potency12.289324
TDP1 proteinHomo sapiens (human)Potency1.381723
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency27.306011
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency63.095711
thyroid stimulating hormone receptorHomo sapiens (human)Potency5.011922
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.251211
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency42.083012

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Acyl carrier protein, mitochondrialBos taurus (cattle)IC500.005011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC5052.300022
Carbonic anhydraseMethanosarcina thermophilaKi6,525.000044
Carbonic anhydrase Astrosclera willeyanaKi27,800.000011
Carbonic anhydrase Pseudomonas aeruginosa PAO1Ki770.000011
Carbonic anhydrase 1Homo sapiens (human)Ki4,164.00621316
Carbonic anhydrase 15Mus musculus (house mouse)Ki16,652.425014
Carbonic anhydrase 2Homo sapiens (human)Ki3,835.75772326
Carbonic anhydrase 4Homo sapiens (human)Ki26,341.940025
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki300.000011
Carbonic anhydrase 9Homo sapiens (human)Ki5.000011
Dihydroorotate dehydrogenase Plasmodium falciparum (malaria parasite P. falciparum)IC5010.000011
Dihydroorotate dehydrogenase (fumarate)Saccharomyces cerevisiae S288CIC5010.000011
Integrase Human immunodeficiency virus 1IC5023,000.600022
Laccase Trametes versicolorIC50266.333333
Mitochondrial succinate dehydrogenase subunit C Zymoseptoria triticiIC5015.001022
Mitogen-activated protein kinase 1Homo sapiens (human)IC502.116011
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki1,510.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialBos taurus (cattle)IC500.005011
NADH-ubiquinone oxidoreductase chain 1Bos taurus (cattle)IC500.004522
Photosystem II protein D1Spinacia oleracea (spinach)IC501.084922
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Ki2.200011
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)Ki3.820011
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialZymoseptoria triticiIC5015.001022

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Oxysterols receptor LXR-alphaHomo sapiens (human)Kd3.240011
Peroxiredoxin-1Homo sapiens (human)Kd2.610011
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