ascorbic-acid and Hyperemesis-Gravidarum

Topics: Adult; Antiemetics; Ascorbic Acid; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Hyperemesis Gravidarum; Prednisolone; Pregnancy; Prochlorperazine; Promethazine

Hyperemesis gravidarum (HG) is severe pregnancy sickness, often leading to dehydration, weight loss and electrolyte disturbances. Little is known about nutritional intake and its consequences in those affected. The aim of this study was to explore the first trimester nutritional intake and clinical characteristics in those with severe sickness.. Recruitment was via the social media accounts of national pregnancy charities. The eligibility criteria were as follows: between 6 and 11 weeks pregnant, age ≥18 years and residing in the UK. Participants completed a self-report online questionnaire including the Pregnancy Unique Quantification of Emesis 24 (PUQE24) score and a 3-day online diet diary. Groups were compared by PUQE24 categories. Nutritional intakes were compared to dietary reference values.. One hundred sixty-six participants took part in the study: 36 categorised with mild, 109 with moderate and 21 with severe symptoms at a median gestation of 8.1 (interquartile range [IQR] 3) weeks. Those in the severe category had significantly higher weight loss (3.0 kg, IQR 3.5) than the mild category (0.0 kg, IQR 0.9). In those who completed the diet diary (n = 70), intakes of energy, carbohydrate, protein, fat, fibre, calcium, iron, zinc, thiamine, riboflavin, folate and vitamin C were all significantly lower in the severe category (p < 0.05). The severe group consumed only 39.5% and 41.6% of energy and protein needs, respectively, and were more likely to stop taking micronutrient supplements (p < 0.05).. Nutritional and supplement intake in those with severe pregnancy sickness was poor; however, intake across all participants was suboptimal. Future research should investigate how to improve nutritional intake across all categories of pregnancy sickness.

Topics: Adolescent; Ascorbic Acid; Female; Humans; Hyperemesis Gravidarum; Nutrition Surveys; Pregnancy; Pregnancy Trimester, First; Vitamins

Topics: Adolescent; Adult; Ascorbic Acid; Female; Humans; Hyperemesis Gravidarum; Nerve Block; Pregnancy; Pregnancy Trimester, First; Procaine

Topics: Ascorbic Acid; Female; Humans; Hyperemesis Gravidarum; Nausea; Pregnancy; Vitamin K

Topics: Adrenal Cortex; Ascorbic Acid; Female; Folic Acid; Humans; Hyperemesis Gravidarum; Pregnancy; Vitamin B Complex; Vitamins

Topics: Ascorbic Acid; Female; Humans; Hyperemesis Gravidarum; Niacin; Pregnancy; Vitamins