A bradykinin agonist that binds to and activates bradykinin B2 receptors.
ChEBI ID: 77496
| Member | Definition | Class |
|---|---|---|
| bradykinin, des-arg(9)- | An eight-membered oligopeptide comprising Arg, Pro, Pro, Gly, Phe, Ser, Pro and Phe residues joined in sequence. It is an analogue of bradykinin lacking the Arg residue at position 9. | [des-Arg(9)]-bradykinin |
| ramipril | A dipeptide that is the prodrug for ramiprilat, the active metabolite obtained by hydrolysis of the ethyl ester group. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. | ramipril |
| ramiprilat | A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure. | ramiprilat |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 187 (8.11) | 18.7374 |
| 1990's | 634 (27.48) | 18.2507 |
| 2000's | 884 (38.32) | 29.6817 |
| 2010's | 503 (21.80) | 24.3611 |
| 2020's | 99 (4.29) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 622 (23.70%) | 5.53% |
| Reviews | 154 (5.87%) | 6.00% |
| Case Studies | 135 (5.14%) | 4.05% |
| Observational | 8 (0.30%) | 0.25% |
| Other | 1,705 (64.98%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 24.5454 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 15.0030 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 6.6819 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 0.2530 | 2 | 2 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |