| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
creatine
[no description available] | 9.32 | 4 | 1 | glycine derivative;
guanidines;
zwitterion | geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent;
nutraceutical |
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical. | 2.66 | 3 | 0 | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | |
nitrites
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed) | 2.36 | 2 | 0 | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | human metabolite |
sarcosine
cocobetaine: N-alkyl-betaine; cause of shampoo dermatitis | 7.36 | 2 | 0 | N-alkylglycine zwitterion;
N-alkylglycine;
N-methyl-amino acid;
N-methylglycines | Escherichia coli metabolite;
glycine receptor agonist;
glycine transporter 1 inhibitor;
human metabolite;
mouse metabolite |
cimetidine
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.. cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. | 1.96 | 1 | 0 | aliphatic sulfide;
guanidines;
imidazoles;
nitrile | adjuvant;
analgesic;
anti-ulcer drug;
H2-receptor antagonist;
P450 inhibitor |
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group. | 1.95 | 1 | 0 | 4-hydroxyproline;
L-alpha-amino acid zwitterion | human metabolite;
mouse metabolite;
plant metabolite |
diethylnitrosamine
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | 2.38 | 2 | 0 | nitrosamine | carcinogenic agent;
hepatotoxic agent;
mutagen |
n-nitrosomorpholine
N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent;
mutagen |
dimethylnitrosamine
Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents. | 2.67 | 3 | 0 | nitrosamine | geroprotector;
mutagen |
n-nitrosodiphenylamine
N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source | 1.96 | 1 | 0 | phenylhydrazines | |
n-nitrosopiperidine
N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite. | 2.38 | 2 | 0 | nitrosamine;
piperidine | apoptosis inducer;
carcinogenic agent;
environmental contaminant;
mutagen |
4-nitrosodimethylaniline
4-nitrosodimethylaniline: structure; RN given refers to parent cpd. N,N-dimethyl-4-nitrosoaniline : A member of the class of dimethylanilines that is N,N-dimethylaniline having a nitroso group at the 4-position. | 2.01 | 1 | 0 | dimethylaniline;
nitroso compound;
tertiary amino compound | |
n,n'-dinitrosopiperazine
N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd | 1.96 | 1 | 0 | | |
thiazoles
[no description available] | 2.89 | 4 | 0 | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | |
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES. | 2.89 | 4 | 0 | thiazolidine | |
diisopropylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-methyl-n-nitrosoaniline
N-methyl-N-nitrosoaniline: structure | 1.96 | 1 | 0 | | |
n-nitroso(di-n-propyl)amine
[no description available] | 2.38 | 2 | 0 | nitroso compound | |
dibutylnitrosamine
dibutylnitrosamine: structure | 1.96 | 1 | 0 | nitroso compound | |
n-nitrosopyrrolidine
N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism. | 2.38 | 2 | 0 | pyrrolidines | |
n-nitrosoperhydroazepine
[no description available] | 1.96 | 1 | 0 | | |
nitrosobenzylmethylamine
nitrosobenzylmethylamine: structure | 2.67 | 3 | 0 | | |
n-nitrosodiethanolamine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
n-nitroso-2,6-dimethylmorpholine
N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation | 1.96 | 1 | 0 | | |
butylhydroxybutylnitrosamine
Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-nitroso-n-methylvinylamine
N-nitroso-N-methylvinylamine: structure given in first source | 1.96 | 1 | 0 | nitroso compound | |
n-nitrosodibenzylamine
N-nitrosodibenzylamine: structure | 1.96 | 1 | 0 | | |
n-nitroso-n-methylcyclohexylamine
[no description available] | 1.96 | 1 | 0 | | |
1-nitrosopiperazine
[no description available] | 1.96 | 1 | 0 | phytanoyl-CoAs | |
nitrosomethyl-n-butylamine
nitrosomethyl-N-butylamine: RN given refers to parent cpd | 1.96 | 1 | 0 | | |
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. | 1.97 | 1 | 0 | chromium group element atom | micronutrient |
meladrazine
nitrosoproline: RN given refers to 1-nitroso-L-proline | 3.67 | 10 | 0 | | |
methylethylnitrosamine
[no description available] | 1.96 | 1 | 0 | nitroso compound | |
n-ethyl-n-hydroxyethylnitrosamine
N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents. | 1.96 | 1 | 0 | nitrosamine;
primary alcohol | carcinogenic agent |
n-amyl-n-methylnitrosamine
N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen. | 1.96 | 1 | 0 | nitrosamine | carcinogenic agent |
vinylethylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
trinitrosotrimethylenetriamine
[no description available] | 1.96 | 1 | 0 | 1,3,5-triazinanes;
nitrosamine | |
diallylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitroso-n'-methylpiperazine
[no description available] | 1.96 | 1 | 0 | | |
n'-nitrosonornicotine
N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals | 1.96 | 1 | 0 | pyridines;
pyrrolidines | |
n-nitrosoephedrine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrosoheptamethyleneimine
[no description available] | 1.96 | 1 | 0 | nitrosamine | |
fluorescamine
Fluorescamine: A nonfluorescent reagent for the detection of primary amines, peptides and proteins. The reaction products are highly fluorescent. | 1.95 | 1 | 0 | | |
diisopropanolnitrosamine
diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney. | 1.96 | 1 | 0 | diol;
nitrosamine;
secondary alcohol | carcinogenic agent |
n-nitrosomethyldodecylamine
N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid | 1.96 | 1 | 0 | | |
n,n-dinitrosohomopiperazine
[no description available] | 1.96 | 1 | 0 | | |
methyl(acetoxymethyl)nitrosamine
methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source | 1.96 | 1 | 0 | | |
nitrosobis(2-oxopropyl)amine
nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible). | 1.96 | 1 | 0 | ketone;
nitrosamine | carcinogenic agent |
n-nitroso-4-hydroxyproline
N-nitroso-4-hydroxyproline: RN given refers to cpd without isomeric designation | 2.65 | 3 | 0 | L-proline derivative | |
n-nitrosoguvacoline
N-nitrosoguvacoline: formed by nitrosation of arecoline | 1.96 | 1 | 0 | citraconoyl group | |
n-nitrososarcosine ethyl ester
[no description available] | 2.37 | 2 | 0 | | |
2-hydroxypropyl-n-propylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
2-oxopropyl-n-propylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
n-nitrosothiazolidine-4-carboxylic acid
N-nitrosothiazolidine-4-carboxylic acid: found in human urine | 2.89 | 4 | 0 | organonitrogen compound;
organooxygen compound | |
3-nitrosomethylaminopyridine
3-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
4-nitrophenyl myo-inositol-1-phosphate
4-nitrophenyl myo-inositol-1-phosphate: structure given in first source; a chromogenic substrate for phosphatidylinositol-specific phospholipase C; RN given refers to monoammonium salt | 2.01 | 1 | 0 | | |
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2. | 2.37 | 2 | 0 | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite |
2-nitrosomethylaminopyridine
2-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
4-nitrosomethylaminopyridine
4-nitrosomethylaminopyridine: structure | 1.96 | 1 | 0 | | |
n,n-diamylnitrosamine
[no description available] | 1.96 | 1 | 0 | | |
riboflavin
vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms). | 1.97 | 1 | 0 | flavin;
vitamin B2 | anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite |
selenium
Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE. | 1.97 | 1 | 0 | chalcogen;
nonmetal atom | micronutrient |
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms. | 1.99 | 1 | 0 | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent |