A compound that inhibits the action of gamma-aminobutyric acid.
ChEBI ID: 65259
| Member | Definition | Class |
|---|---|---|
| clozapine | A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. | clozapine |
| flumazenil | An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose. | flumazenil |
| megestrol acetate | A sesquiterpene lactone with formula C15H20O8. It is a neurotoxic natural product found in plants of the family Illiciaceae. | anisatin |
| picrotoxinin | A picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin. | picrotoxinin |
| suramin | A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. | suramin |
| suramin sodium | An organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. | suramin sodium |
| xenovulene a | A sesquiterpenoid based on a humulene skeleton. It is isolated from Sarocladium strictum and has been shown to exhibit inhibitory activity against GABA receptor. | xenovulene A |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,200 (13.43) | 18.7374 |
| 1990's | 4,992 (30.48) | 18.2507 |
| 2000's | 4,249 (25.94) | 29.6817 |
| 2010's | 3,626 (22.14) | 24.3611 |
| 2020's | 1,311 (8.00) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,265 (7.25%) | 5.53% |
| Reviews | 1,615 (9.25%) | 6.00% |
| Case Studies | 2,308 (13.22%) | 4.05% |
| Observational | 78 (0.45%) | 0.25% |
| Other | 12,189 (69.83%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 12.3018 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 19.3586 | 6 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0953 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 2.3100 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 15.2718 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 7.0795 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 10.3992 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.2535 | 2 | 5 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 23.5870 | 3 | 5 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 17.9008 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 23.4441 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 13.7544 | 3 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 4.3981 | 2 | 7 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 23.4441 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 13.3519 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 26.1761 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 11.2641 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 23.7358 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 17.3768 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.4680 | 3 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 40.1620 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 40.4226 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 0.0658 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 9.5307 | 2 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.2909 | 5 | 5 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 20.8364 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.8979 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.0931 | 4 | 7 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 24.9053 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 26.1761 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| galactokinase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 23.7358 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 0.3264 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 7.9552 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 19.5064 | 1 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 15.7579 | 1 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 2.6832 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 21.2020 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 8.9125 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 17.4733 | 2 | 9 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.9315 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 11.0344 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 26.1761 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 2.1314 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 10.3225 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 26.1761 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 4.4175 | 1 | 3 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 26.1761 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.7025 | 2 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 31.8686 | 2 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 22.1969 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.4589 | 2 | 7 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 1.1337 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 0.1122 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 0.6774 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 16.7842 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 4.6837 | 2 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 19.9554 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 14.5063 | 3 | 4 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 18.0691 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 47.7548 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 0.0750 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 69.6926 | 1 | 3 |
| Platelet-activating factor receptor | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| polyprotein | Zika virus | Potency | 24.9053 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 6.3046 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 17.5594 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 22.5531 | 3 | 3 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 0.7943 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 31.6228 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 6.6824 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0068 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 17.7828 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 8.3561 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.2440 | 2 | 12 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 13.1145 | 3 | 6 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.9811 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 21.6403 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 11.0684 | 2 | 4 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.5955 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 33.4915 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | IC50 | 2.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.2695 | 3 | 4 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.1657 | 15 | 18 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.1451 | 9 | 9 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.3730 | 3 | 3 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.1521 | 2 | 2 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0658 | 3 | 5 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0886 | 11 | 11 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0156 | 34 | 38 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0123 | 22 | 23 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0810 | 2 | 4 |
| 5-hydroxytryptamine receptor 2B | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0338 | 7 | 7 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0051 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0137 | 7 | 7 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0658 | 3 | 5 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0310 | 8 | 8 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.0154 | 23 | 26 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0135 | 10 | 10 |
| 5-hydroxytryptamine receptor 2C | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Cavia porcellus (domestic guinea pig) | IC50 | 110.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 0.3348 | 3 | 3 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 0.0320 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0320 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.0095 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.2239 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0171 | 4 | 4 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0170 | 17 | 20 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.3338 | 28 | 33 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0094 | 2 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.3530 | 1 | 1 |
| Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 1.4700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.4580 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0567 | 7 | 8 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0201 | 6 | 6 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0865 | 9 | 11 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0567 | 7 | 8 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0203 | 5 | 5 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0858 | 10 | 11 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.0350 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0567 | 7 | 8 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0198 | 6 | 6 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1008 | 8 | 9 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0900 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0908 | 5 | 5 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0758 | 6 | 7 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0230 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.0740 | 3 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0823 | 4 | 5 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.0079 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0538 | 4 | 4 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.0823 | 4 | 5 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 6.2855 | 2 | 2 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 8.6606 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent 6-phosphofructokinase | Trypanosoma brucei brucei | IC50 | 3.0000 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 18.0000 | 2 | 2 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.1500 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 285.6378 | 5 | 9 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 598.2500 | 1 | 2 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 80.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cathepsin B | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | Ki | 0.0600 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0170 | 1 | 2 |
| D | Bos taurus (cattle) | IC50 | 4.0900 | 2 | 2 |
| D | Rattus norvegicus (Norway rat) | IC50 | 1.0660 | 8 | 12 |
| D | Bos taurus (cattle) | Ki | 0.4200 | 8 | 13 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.2369 | 13 | 16 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.1070 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.1342 | 12 | 12 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.4890 | 2 | 2 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1742 | 2 | 2 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 1.8040 | 5 | 5 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.2044 | 8 | 9 |
| D(2) dopamine receptor | Mus musculus (house mouse) | IC50 | 0.2900 | 1 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6759 | 19 | 25 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.6900 | 1 | 1 |
| D(2) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.2540 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.1296 | 69 | 72 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1693 | 25 | 37 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.3540 | 2 | 2 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 3.0773 | 6 | 8 |
| D(3) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.4660 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.4831 | 34 | 34 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.3298 | 5 | 5 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.0796 | 12 | 12 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.2028 | 51 | 51 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0975 | 4 | 4 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 8.2000 | 1 | 1 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| Dual specificity protein phosphatase 5 | Homo sapiens (human) | Ki | 0.0250 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 300.0000 | 2 | 2 |
| Ectonucleoside triphosphate diphosphohydrolase 2 | Rattus norvegicus (Norway rat) | Ki | 65.4000 | 2 | 2 |
| Ectonucleoside triphosphate diphosphohydrolase 3 | Rattus norvegicus (Norway rat) | Ki | 12.7000 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 8 | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0126 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | Ki | 0.0008 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 0.0049 | 7 | 32 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 0.0317 | 9 | 9 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | Ki | 0.0008 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 0.0049 | 7 | 32 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | Ki | 0.0008 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 0.0050 | 7 | 32 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.0224 | 8 | 8 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | Ki | 0.0008 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.0052 | 4 | 29 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 0.0049 | 6 | 31 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 0.0195 | 6 | 31 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.0292 | 12 | 12 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | Ki | 0.0008 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.0055 | 5 | 30 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0305 | 15 | 15 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 0.0254 | 12 | 12 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.7510 | 2 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | IC50 | 0.0005 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | Ki | 0.0008 | 5 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 0.0117 | 15 | 40 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 0.0305 | 15 | 15 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.6679 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 0.0255 | 7 | 7 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 0.0009 | 2 | 2 |
| Gastrin/cholecystokinin type B receptor | Mus musculus (house mouse) | Ki | 0.0038 | 1 | 2 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 2.4000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0049 | 1 | 1 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 2 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0126 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0035 | 8 | 8 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 3.6100 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 3.5500 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 0.8155 | 2 | 2 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 0.1925 | 3 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.0096 | 3 | 3 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.1233 | 4 | 7 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.0079 | 6 | 6 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0136 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 0.4760 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.1015 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0356 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.0780 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.0255 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.0450 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.0176 | 3 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.0130 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.1534 | 4 | 5 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.0218 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| NAD-dependent protein deacetylase HST2 | Saccharomyces cerevisiae S288C | IC50 | 240.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | IC50 | 1.3857 | 7 | 7 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 1.1750 | 4 | 4 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | IC50 | 20.6000 | 8 | 8 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 0.0900 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0009 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 10.5710 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 8.6606 | 1 | 1 |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | IC50 | 21.9054 | 1 | 2 |
| P2Y purinoceptor 11 | Homo sapiens (human) | Ki | 0.2071 | 2 | 2 |
| P2Y purinoceptor 2 | Homo sapiens (human) | IC50 | 75.0000 | 2 | 2 |
| P2Y purinoceptor 6 | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 2.1791 | 11 | 12 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 9.9601 | 5 | 5 |
| Protein arginine N-methyltransferase 1 | Homo sapiens (human) | IC50 | 344.8100 | 3 | 3 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C iota type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 12.2000 | 2 | 2 |
| RmtA | Aspergillus nidulans | IC50 | 5.9000 | 1 | 1 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 8.5000 | 1 | 1 |
| Signal transducer and activator of transcription 1-alpha/beta | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| Signal transducer and activator of transcription 3 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Signal transducer and activator of transcription 5A | Homo sapiens (human) | IC50 | 9.4000 | 1 | 1 |
| Signal transducer and activator of transcription 5B | Homo sapiens (human) | IC50 | 10.4000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.2392 | 4 | 5 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.0210 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.4700 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.4580 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.5460 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 2.0950 | 2 | 2 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.5435 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 9.7600 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 0.1259 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 0.2500 | 1 | 1 |
| Albumin | Rattus norvegicus (Norway rat) | Kd | 78.8000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Calmodulin | Bos taurus (cattle) | Kd | 61.0000 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Kd | 0.0020 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Kd | 0.0004 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Kd | 0.0005 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Kd | 0.0004 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Kd | 0.0004 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | EC50 | 0.0004 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Kd | 0.0031 | 1 | 1 |
| Histamine H4 receptor | Homo sapiens (human) | Kd | 0.0294 | 4 | 4 |
| Kappa-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 1.3000 | 1 | 1 |
| P2X purinoceptor 1 | Rattus norvegicus (Norway rat) | EC50 | 1.0000 | 1 | 1 |
| P2X purinoceptor 2 | Rattus norvegicus (Norway rat) | EC50 | 10.4000 | 1 | 1 |
| P2X purinoceptor 3 | Homo sapiens (human) | EC50 | 8.9500 | 2 | 2 |
| P2X purinoceptor 4 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| P2X purinoceptor 5 | Rattus norvegicus (Norway rat) | EC50 | 4.0000 | 1 | 1 |
| P2X purinoceptor 6 | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| P2X purinoceptor 7 | Homo sapiens (human) | EC50 | 92.0000 | 1 | 1 |
| P2Y purinoceptor 1 | Meleagris gallopavo (turkey) | EC50 | 10.0000 | 1 | 1 |
| P2Y purinoceptor 11 | Homo sapiens (human) | EC50 | 16.0000 | 1 | 1 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | EC50 | 4.0000 | 1 | 1 |
| P2Y purinoceptor 2 | Homo sapiens (human) | EC50 | 48.0000 | 1 | 1 |
| P2Y purinoceptor 4 | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| short transient receptor potential channel 6 isoform 1 | Mus musculus (house mouse) | EC50 | 15.8500 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Activity | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | INH | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | INH | 0.0064 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 58.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Km | 43.7667 | 3 | 3 |
| Cytochrome P450 2J2 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Km | 45.2400 | 4 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Activity | 0.2560 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | pKi | 0.0069 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | pKi | 0.0066 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | pKi | 0.0073 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Activity | 0.0012 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | INH | 0.0012 | 1 | 1 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 62.0000 | 1 | 1 |