Page last updated: 2024-12-07

sb 211475

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

SB 211475: a carvedilol metabolite; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID127014
CHEMBL ID3741650
SCHEMBL ID8587275
MeSH IDM0229924

Synonyms (13)

Synonym
sb 211475
3-hydroxy carvedilol
FT-0669338
4-[2-hydroxy-3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-9h-carbazol-3-ol
(4-(2-hydroxy-3-((2-(2-methoxy-phenoxy)ethyl)amino)propoxyl)-9h-carbazol-3-ol)
146574-43-8
sb-211475
9h-carbazol-3-ol, 4-(2-hydroxy-3-((2-(2-methoxyphenoxy)ethyl)amino)propoxy)-, (+-)-
SCHEMBL8587275
CHEMBL3741650
DTXSID20932859
4-(2-hydroxy-3-{[2-(2-methoxyphenoxy)ethyl]amino}propoxy)-9h-carbazol-3-ol
AKOS040749414

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1265767Inhibition of RyR2 R4496C mutant in HEK293 cells assessed as inhibition of store overload-induced calcium release at 10 uM by fura-2 AM dye based fluorescence assay2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol.
AID1265768Inhibition of RyR2 R4496C mutant in HEK293 cells assessed as inhibition of store overload-induced calcium release at 30 uM by fura-2 AM dye based fluorescence assay2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol.
AID1265769Induction of cytosolic calcium level in HEK293 cells expressing RyR2 R4496C mutant at 30 uM by fura-2 AM dye based fluorescence assay2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol.
AID1265766Inhibition of RyR2 R4496C mutant-mediated store overload-induced calcium release in HEK293 cells assessed as reduction in amplitude of spontaneous calcium oscillations by fura-2 AM dye based fluorescence assay2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol.
AID1265770Inhibition of RyR2 R4496C mutant in HEK293 cells assessed as reduction of caffeine-induced calcium release at 30 uM by fura-2 AM dye based fluorescence assay2016Bioorganic & medicinal chemistry letters, Jan-01, Volume: 26, Issue:1
Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (66.67)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]