Page last updated: 2024-09-27

Obesity

A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Synonyms(1)

Synonym
Obesity

Research Excerpts

Overview

ExcerptReference
"Obesity is very common in South Africal Black girls aged 18 - 20 years."( Bhamjee, D; Martin, AP; Walker, AR; Walker, BF, 1979)
"The onset of obesity is at 4--6 months, and adipose mice suffer from hyperinsulinaemia; the sexes differ in penetrance, males having greater penetrance then females."( MacSwiney, FM; Wallace, ME, 1979)
"Obesity is the common expression of several diverse interacting genetic, familial and environmental factors."( Angel, A, 1978)
"Several models of obesity are compared and a possible role for the hypothalamus in the regulation of fat stores is discussed."( Wise, A, 1975)
"Hyperphagia and obesity are produced both by parasagittal knife cuts through the medial hypothalamus and by coronal knife cuts through the posterior hypothalamus."( Berner, CN; Sclafani, A, 1977)
"Since obesity is often accompanied by hyperinsulinemia and since hyperinsulinemia may participate in production of hypertriglyceridemia, we investigated the effect of oral contraceptives on the serum lipids of obese women."( Galler, M; Gershberg, H; Hulse, M, 1976)
"Obesity is variably considered to be a major contributor to hypertension and hyperlipidemia, and its treatment is recommended in the management of coronary heart disease."( Fuchs, RJ; Kay, TD; Lancaster, MC; Triebwasser, JH; Weinsier, RL, 1976)
"The problems of obesity are well documented, but few medical treatment programs have proven successful."( Brightwell, DR; Clancy, J, 1976)
"Obesity is associated with an increased cholesterol synthetic rate equal to 20 mg/day for each kilogram of body fat."( Dell, RB; Schreibman, PH, 1975)
"The problem of obesity is not well dealt with in the ordinary diabetes clinic."( Goldblatt, R; Jackson, WP; Movsowitz, F, 1975)
"Obesity is defined with reference to hte probable cellular differences in adolescent and maturity-onset obesity."( Mazansky, H, 1975)
"Obesity is one of the most common prosperity diseases."( Förster, H, 1976)
"Obesity is associated with altered bone mass."( Foldes, J; Levy, J; Shih, MS, 1992)
"Obesity is characterized by peripheral hyperinsulinemia, for which either beta-cell hypersecretion, diminished hepatic insulin extraction, or both may be responsible."( Kautzky-Willer, A; Ludvik, B; Pacini, G; Prager, R; Schernthaner, G, 1992)
"Obesity is characterized by a high risk for glucose intolerance and cardiovascular disease."( De Leeuw, I; Van Gaal, L; Vansant, G, 1992)
"Increasing obesity is associated with increased blood lactate levels after an overnight fast."( DiGirolamo, M; Gebhart, SS; Lovejoy, J; Newby, FD, 1992)
"While obesity is frequently associated with arterial hypertension, the underlying mechanism is still poorly understood."( Kolanowski, J, 1992)
"Obesity is a well-known risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM)."( Scheen, AJ, 1992)
"The patient's obesity is hypothesized as the causal factor for increased estrogen levels leading to growth of the fibroadenoma."( Bassett, LW; Fu, YS; Gade, NR; Suk, JJ; Swisher, RC, 1992)
"Obesity is associated with blunted GH secretion."( Casanueva, FF; Cordido, F; Diéguez, C; Morales, MJ; Muruais, C, 1991)
"Human obesity is a heterogeneous group from the aspect of topographical fat distribution."( Fujioka, S; Matsuzawa, Y; Tarui, S; Tokunaga, K, 1991)
"Obesity is not a confounding factor in the 1-mg dexamethasone suppression test."( Fok, AC; Jacob, E; Sum, CF; Tan, KT, 1991)
"Obesity is a strong early predictor for the development of hypertension as a person progresses from childhood into adult life."( Ram, JL; Resnick, LM; Sowers, JR; Standley, PR; Zemel, MB, 1991)
"Abdominal obesity is an independent cardiovascular risk factor."( Gustafson, AB; Hennes, MI; Kissebah, AH; Peiris, AN; Sothmann, MS; Thakur, RK; Wilson, CR, 1991)
"Obesity is an important determinant of serum lipids and lipoproteins in adults."( Berenson, GS; Harsha, DW; Srinivasan, SR; Wattigney, WA; Webber, LS, 1991)
"Obesity is a condition associated with an increased frequency of gallstone disease."( Aldini, R; Bazzoli, F; Festi, D; Grigolo, B; Mazzella, G; Roda, A; Roda, E; Ronchi, M; Simoni, P; Villanova, N, 1991)
"Profound obesity is conferred on the Zucker rat by homozygosity for a recessive gene (fa/fa); the heterozygous animal is lean."( Galbraith, RA; Kappas, A, 1990)
"Obesity is usually associated with expansion of blood volume."( Hirata, Y; Iida, T; Ikeda, K; Nakagawa, S; Takahashi, H, 1990)
"Obesity is associated with an impairment of the GH secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown."( Casanueva, FF; Cordido, F; Dieguez, C, 1990)
"Since obesity is frequently associated with hypertension, even before the development of overt diabetes, we evaluated blood pressure and erythrocyte cation levels and membrane Na/K-ATPase and Ca-ATPase in Zucker obese rats and their lean controls (n = 10 per group)."( Levy, J; Shehin, S; Sowers, JR; Walsh, MF; Zemel, MB, 1990)
"Obesity is characterized by decreased rates of skeletal muscle insulin-mediated glucose uptake (IMGU)."( Baron, AD; Brechtel, G; Edelman, SV; Laakso, M, 1990)
"Although obesity is associated with many risk factors for diseases, the mechanisms whereby it enhances disease risk are not fully understood."( Barnett, JP; Grundy, SM, 1990)
"Hyperphagia and obesity are often associated, and the origins of the biochemical modifications leading to these syndromes might be in the hypothalamus."( Beck, B; Burlet, A; Burlet, C; Nicolas, JP, 1990)
"Obesity is associated with insulin resistance and type II diabetes mellitus."( Hurrell, DG; Kahn, CR; Pedersen, O, 1989)
"Abdominal obesity is associated with high plasma triglyceride (TG) and with low plasma high density lipoprotein (HDL)-cholesterol (CHOL) levels."( Bouchard, C; Després, JP; Ferland, M; Lupien, PJ; Moorjani, S; Nadeau, A; Tremblay, A, 1989)
"Obesity is a major health problem that can be defined as an excess of body fat, associated with hypertension, diabetes and coronary heart disease."( Rivera, MP; Svec, F, 1989)
"Obesity is associated with increased morbidity and may reduce compliance, leading to a return of psychotic symptoms."( Goodall, E; Silverstone, T; Smith, G, 1988)
"Obesity is associated with glucose intolerance."( Landin, K; Lindgärde, F; Saltin, B; Wilhelmsen, L, 1989)
"Obesity is associated with a moderate diminution of hepatic and peripheral insulin sensitivity."( Kissebah, AH; Lee, MB; Mueller, RA; Peiris, AN; Struve, MF, 1988)
"Thus, massive obesity is associated with abnormalities in hormonal balance in gynecologically symptomless women, there being an association between E1, E2, A, LH, cortisol, and relative weight and/or abdominal fat cell size."( Grenman, S; Grönroos, M; Irjala, K; Kaihola, HL; Rönnemaa, T, 1986)
"Obesity is associated with an increased risk of diabetes."( Bogardus, C; Lillioja, S, 1988)
"Obesity is characterized by an impairment of GH release in response to various stimuli."( Altomonte, L; Berchicci, M; Greco, AV; Mirone, L; Pellicano, P; Travaglini, R; Zoli, A, 1988)
"Obesity is characterized by increased levels of insulin and by subnormal growth hormone (GH) release."( Altomonte, L; Ghirlanda, G; Greco, AV; Manna, R; Zoli, A, 1988)
"Since obesity is related to clustering of risk factor variables in children and young adults, the prevention of the onset of obesity in early life may be important to reducing the risk of coronary heart disease in later life."( Berenson, GS; Burke, GL; Harsha, DW; Smoak, CG; Srinivasan, SR; Webber, LS, 1987)
"Additionally, obesity is associated with increased estrogen production secondary to increased peripheral aromatization."( Bradlow, HL; Hershcopf, RJ, 1987)
"Abdominal obesity is also associated with greater aberrations in metabolism than peripheral obesity."( Smith, U, 1985)
"Obesity is a major cause of shortened life expectancy."( Wittels, EH, 1985)
"Obesity is another occasional effect of large doses."( Crammer, JL; Crane, G; Rosser, RM, 1974)
"Thus obesity is associated with enhanced capacity for biotransformation of drugs via glucuronide conjugation."( Abernethy, DR; Divoll, M; Greenblatt, DJ; Shader, RI, 1983)
"Obesity is a circumstance characterized in the dog fat cell by a modification of the balance between alpha-2 and beta receptors."( Berlan, M; Carpene, C; Dang-Tran, L; Lafontan, M, 1982)
"Obesity is characterized by insulin resistance which predisposes to the development of impaired glucose tolerance."( Felig, P, 1984)
"In conclusion, obesity is characterized by a dilution of the insulin receptor over the adipocyte cell surface in the absence of a change in total cellular content of receptors."( Arner, P; Backman, L; Bolinder, J; Kager, L; Lerea, KM; Livingston, JN, 1984)
"Thus, obesity is a state of increased androgen production and accelerated clearance."( Ertel, NH; Kirschner, MA; Samojlik, E; Schneider, G; Silber, D, 1984)
"Obesity is common amongst the Maoris and accentuates their natural tendency to hyperuricaemia."( Bremner, K; Gibson, T; Hatfield, P; Robinson, G; Waterworth, R, 1984)
"Obesity is accompanied by altered secretion and disposition of sex and glucocorticoid hormones, including cortisol, and also confounds parameter normalization and drug dosage selection relative to body weight."( Jusko, WJ; Milsap, RL; Plaisance, KI, 1984)
"Obesity is associated with an increased incidence of reproductive dysfunction and estrogen-linked diseases."( Anderson, K; Bradlow, HL; Fishman, J; Levin, J; Schneider, J; Strain, G, 1983)
"It is clear that obesity is a key risk factor for endometrial cancer, particularly as this obesity appears to be related to a high fat diet and consequently to higher levels of plasma urinary estrogens."( Eyler, N; Mahboubi, E; Wynder, EL, 1982)
"On the other hand, obesity is associated with IRGIP hypersecretion, and glucose intolerance has no further effect, indicating a different pathogenetic mechanism for the IRGIP abnormalities."( Barbara, L; Benfenati, F; Capelli, M; Cornia, G; Giacomoni, P; Marini, A; Miglioli, M; Pironi, L; Salera, M, 1982)
"Obesity is often associated with an elevated total body cholesterol synthesis."( Angelin, B; Backman, L; Einarsson, K; Eriksson, L; Ewerth, S, 1982)
"Obesity is known to affect many aspects of the metabolism of steroid hormones."( Fotherby, K; Koetsawang, S, 1982)
"Obesity is a physiological state associated with alterations in hormone production and metabolism."( Ertel, N; Kirschner, MA; Schneider, G, 1981)
"Rats whose future obesity is predictable using this method, have significantly elevated serum levels of triacylglycerols, total cholesterol and phospholipids."( Bach, A; Boulangé, A; de Gasquet, P; Schirardin, H, 1981)
"The prevalence of obesity is slightly higher than reported in previous studies in Taiwan."( Chu, NF; Ding, YA; Lin, CC; Wang, TW, 1995)
"Obesity is a disorder of energy balance, indicating a chronic disequilibrium between energy intake and expenditure."( Auwerx, J; De Vos, P; Girard, J; Guerre-Millo, M; Leturque, A; Saladin, R; Staels, B, 1995)
"Obesity is accompanied by complications such as hypertension, non-insulin-dependent diabetes mellitus and atherosclerosis, which in turn cause ischaemic heart disease, stroke and premature death."( Arner, P; Lönnqvist, F; Nordfors, L; Schalling, M, 1995)
"Abdominal obesity is associated with defects in insulin-regulated oxidative and nonoxidative glucose disposal as well as in insulin suppression of hepatic glucose production."( Egan, BM; Hoffmann, RG; Kelly, TM; Kissebah, AH; Myers, TJ; Nazzaro, P; O'Shaughnessy, IM; Stepniakowski, K, 1995)
"Obesity is associated with an impairment of normal GH secretion and blunted responses to all stimuli."( Cho, JH; Huh, KB; Kim, KR; Lee, EJ; Lee, HC; Lim, SK; Nam, MS; Nam, SY; Song, YD, 1995)
"Obesity is a common finding in diabetic felines and is a contributing factor to the insulin resistance present in type 2 diabetes."( Lutz, TA; Rand, JS, 1995)
"Thus, genetic obesity is associated with increased intestinal growth, which augments absorption of all types of nutrients."( Ferraris, RP; Vinnakota, RR, 1995)
"Visceral obesity is strongly associated with insulin resistance."( Colberg, SR; Kelley, DE; Simoneau, JA; Thaete, FL, 1995)
"Human obesity is characterized by profound alterations in the hemodynamic and metabolic states."( Bolla, GB; Brunani, A; Cattaneo, BM; Cavagnini, F; Colombo, M; Giannattasio, C; Grassi, G; Lanfranchi, A; Mancia, G; Seravalle, G, 1995)
"Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis."( Arner, P; Atkinson, RL; Caro, JF; Hotamisligil, GS; Spiegelman, BM, 1995)
"Obesity is considered to be one of the major risk factors for developing non-insulin dependent diabetes mellitus (NIDDM)."( Kashiwagi, A; Maegawa, H; Shigeta, Y, 1995)
"Since abdominal obesity is associated with impaired fibrinolytic capacity and elevated levels of plasminogen activator inhibitor (PAI-1) and since PAI-1 seems to be related to insulin resistance, we investigated the possible effects of dietary intervention on lipids, fibrinolysis, coagulation, and insulin sensitivity in obese PCOS women."( Abdelnoor, M; Andersen, P; Arnesen, H; Birkeland, K; Dale, PO; Løvik, A; Seljeflot, I, 1995)
"In addition, obesity is associated with a slight prolongation of antipyrine t1/2 whereas its CL0 is unaltered."( Berry, EM; Caraco, Y; Levy, M; Zylber-Katz, E, 1995)
"Massive obesity is characterized by enhanced fatty acid turnover, insulin resistance, and often a fatty liver."( Backman, L; Cederblad, G; Harper, P; Wadström, C, 1995)
"Moreover, obesity is generally associated with a higher risk of developing NIDDM."( Kadowaki, T; Yoshinaga, H, 1994)
"Obesity is a social disease and amounts to a real medical problem."( Cotrozzi, G; Fontana, R; Relli, P, 1994)
"Obesity is a vast and ever-expanding problem in affluent societies, which we have so far failed to confront."( Dryden, S; Frankish, H; Wang, Q; Williams, G, 1994)
"Obesity is associated with blunted growth hormone (GH) levels and pulsatility and elevated plasma free fatty acids (FFA) levels."( Andreotti, AC; Caumo, A; Lanzi, R; Manzoni, MF; Moreschi, A; Pontiroli, AE, 1994)
"Adult obesity is most common in Uruguay (about 50%)."( , 1994)
"Since upper body obesity is characterized by androgen excess, a relationship between body fat distribution, sex hormones, RMR and indices of thermogenesis was studied."( De Leeuw, IH; Van Gaal, LF; Vansant, GA; Vanuytsel, JL, 1994)
"Obesity is a product of welfare."( Vermeulen, A, 1993)
"Obesity is associated with an increased incidence of cardiovascular complications, but the underlying mechanism is unknown."( Jéquier, E; Nicod, P; Randin, D; Scherrer, U; Tappy, L; Vollenweider, P, 1994)
"Obesity is a common problem among Type 2 diabetic patients."( Chong, PK; Jung, RT; Rennie, MJ; Scrimgeour, CM, 1993)
"As obesity is a major risk factor for noninsulin-dependent diabetes mellitus, adipose tissue may generate a mediator that influences the activity of insulin on various target tissues."( Braithwaite, SS; Colca, JR; Hofmann, C; Hotamisligil, GS; Lorenz, K; Palazuk, BJ; Spiegelman, BM, 1994)
"Obesity is considered to be a major factor in the pathogenesis of hypertension in industrialized countries."( Granger, JP; Scott, J; West, D, 1994)
"Insulin action and obesity are both correlated with the density of muscle capillary supply in humans."( Bergman, R; Bogardus, C; Castillo, C; Lillioja, S; Thuillez, P, 1994)
"Obesity is characterized by increased adipose tissue mass and is often accompanied by a number of other disorders, such as diabetes, hypertension, and hyperlipidemia."( Graves, RA; Ross, SR; Spiegelman, BM, 1993)
"Severe obesity is known to reduce either dehydroepiandrosterone circulating levels or growth hormone (GH) and insulin-like growth factor-1 (IGF-1) secretion."( Cignarelli, M; Cospite, MR; De Pergola, G; Garruti, G; Giagulli, VA; Giorgino, F; Giorgino, R, 1993)
"Obesity is characterized by hyperinsulinemia, which reflects peripheral insulin resistance."( Fujiwara, T; Horikoshi, H; Ikeda, K; Koike, H; Nishino, H; Okuno, A; Shiraki, T; Wada, M; Yoshioka, S, 1993)
"The prevalence of obesity is known to increase in rats by this age."( Himms-Hagen, J; Melnyk, A, 1995)
"Central obesity is a strong predictor of higher prevalence of diabetes, hypertension and coronary artery disease among Indian immigrants to Britain."( Beegom, R; Niaz, MA; Singh, RB, 1995)
"Severe obesity is a greater risk factor for incisional hernia and hernia recurrence than chronic steroid use in nonobese colitis patients."( DeMaria, EJ; Kellum, JM; Lowry, JW; Newsome, HH; Reines, HD; Sugerman, HJ, 1996)
"Obesity is a multifactorial heterogenous condition."( Chrousos, GP; Peeke, PM, 1995)
"Obesity is known to predispose to attenuated fibrinolysis attributable to increased concentrations in plasma of type-1 plasminogen activator inhibitor (PAI-1), the primary physiological inhibitor of endogenous fibrinolysis."( Brown, SL; Fujii, S; Lundgren, CH; Nordt, TK; Sobel, BE, 1996)
"Human obesity is also associated with increased leptin mRNA as well as plasma levels, but there have been no reports of the effect of insulin on leptin secretion."( Brothers, J; Dagogo-Jack, S; Fanelli, C; Landt, M; Paramore, D, 1996)
"Although obesity is associated with insulin resistance, most obese humans and rodents remain normoglycemic because of compensatory hyperinsulinemia."( Hirose, H; Inman, LR; Johnson, JH; Lee, YH; Nagasawa, Y; Unger, RH, 1996)
"Obesity is associated with an impairment of normal growth hormone (GH) secretion and blunted responses to all stimuli."( Cho, JH; Huh, KB; Kim, KR; Lee, HC; Nam, MS; Nam, SY, 1996)
"Obesity is an independent risk factor for CHD mortality among men and also contributes to the risk of CHD among women."( Jousilahti, P; Pekkanen, J; Puska, P; Tuomilehto, J; Vartiainen, E, 1996)
"Obesity is a major health care concern because of its associated medical complications and increased mortality."( Goldstein, DJ; Hamilton, SH; Rampey, AH; Roback, PJ; Sayler, ME; Tollefson, GD; Wilson, MG, 1995)
"Obesity is coupled to several disturbances of the endocrine axes."( Cattaneo, L; Cocchi, D; De Gennaro Colonna, V; Müller, E; Zoli, M, 1996)
"Obesity is an important risk factor for development of OA at the tibiofemoral and patellofemoral joints of the knee and CMC joints of the hands, with significant increases of 9-13% in risk of OA per kg increase in body weight."( Baker, JR; Cicuttini, FM; Spector, TD, 1996)
"Since human obesity is frequently associated with elevated circulating leptin levels, a state of decreased leptin sensitivity (i."( Cusin, I; Jeanrenaud, B; Rohner-Jeanrenaud, F; Stricker-Krongrad, A, 1996)
"Obesity is an important determinant of EC, probably because of its effect on the hormonal milieu of both pre- and postmenopausal women."( Austin, H; Hill, HA, 1996)
"Obesity is a highly prevalent disease, which is associated with a number of chronic conditions and, as such, represents a major public health burden."( Boerwinkle, E; Bray, MS; Hanis, CL, 1996)
"Obesity is considered a protective factor for osteoporosis improving bone mass and maintaining higher levels of estrogen during menopause."( Albala, C; Devoto, E; Santos, JL; Sostin, C; Yáñez, M; Zeballos, L, 1996)
"Obesity is a heterogeneous condition and not every obese patient is at increased risk of cardiovascular diseases (CVD)."( Bélanger, A; Després, JP; Labrie, F; Tchernof, A, 1996)
"This obesity is accompanied by elevated medial hypothalamic extracellular norepinephrine levels."( Jones, AP; Olster, DH; States, B, 1996)
"Because obesity is associated with changes in receptor signaling in many animal models, we also explored the influence of this clinical risk factor."( Shatos, MA; Shreeve, SM; Thorin, E, 1996)
"Obesity is a complex disease which results from the interaction of multiple genes and the environment."( Caro, JF; Considine, RV, 1996)
"Hyperphagia and obesity are characteristics of hypercortisolism."( Attanasio, A; Blum, WF; Englaro, P; Hanitsch, S; Kiess, W; Rascher, W, 1996)
"Obesity is strongly associated with coronary artery disease (CAD) and may be an independent risk factor; however, limited data are available on obesity intervention in patients with CAD."( Lavie, CJ; Milani, RV, 1997)
"Obesity is a major predisposing factor for the development of several chronic diseases including non-insulin dependent diabetes mellitus (NIDDM) and coronary heart disease (CHD)."( Almasy, L; Blangero, J; Comuzzie, AG; Dyer, TD; Hixson, JE; MacCluer, JW; Mahaney, MC; Mitchell, BD; Stern, MP, 1997)
"Since obesity is associated with enhanced sympathetic nervous activity, the purpose of this study was to test the hypothesis that obese animals have a reduced ability to excrete a sodium load as a result of abnormal renal nerve function."( Granger, JP; Kassab, S; Kato, T; Mizelle, L; Wilkins, FC, 1997)
"Abdominal obesity is associated with blunted GH secretion and low serum insulin-like growth factor-I concentrations."( Bengtsson, BA; Björntorp, P; Johannsson, G; Lönn, L; Mårin, P; Ottosson, M; Sjöström, L; Stenlöf, K, 1997)
"Obesity is a chronic condition that is accompanied by a number of metabolic complications."( Davis, R; Faulds, D, 1996)
"Abdominal obesity is an important risk factor for the development of non-insulin dependent diabetes mellitus and other atherogenic disorders."( Arner, P; Lönnqvist, F; Wennlund, A, 1997)
"Obesity is a major health concern which must be treated."( Guy-Grand, B, 1997)
"Obesity is an important risk factor for hypertension, however the physiologic basis for this relationship has not been clarified."( Bennett, FI; Cooper, R; Forrester, T; McFarlane-Anderson, N; Puras, A; Tewksbury, D; Ward, R; Wilks, R, 1997)
"Obesity is a major risk factor for morbidity and mortality, and a series of pharmacologic approaches are available for helping to manage the problem."( Abdeen, MA; Frishman, WH; Michaelson, MD; Weiser, M, 1997)
"Obesity is a complex condition."( Senior, K, 1997)
"Obesity is common among our adult patients, and is associated with some of their common health problems."( Cole, C; Edwards, M; Esquiro, J; Jackson, A, 1996)
"Obesity is highly associated with insulin resistance and is the biggest risk factor for non-insulin-dependent diabetes mellitus."( Hotamisligil, GS; Marino, MW; Uysal, KT; Wiesbrock, SM, 1997)
"Obesity is associated with both insulin resistance and hyperinsulinemia."( Chen, G; Koyama, K; Lee, Y; Unger, RH, 1997)
"Visceral obesity is frequently associated with muscle insulin resistance."( Chen, M; Han, DH; Hansen, PA; Holloszy, JO; Nolte, LA, 1997)
"Because abdominal obesity is commonly associated with elevated plasma free fatty acid (FFA) flux, we examined the effects of augmenting FFA on plasma leptin levels in women who were lean and of suppressing FFA in women with abdominal obesity."( Dua, A; Hennes, MM; Kissebah, AH; Krakower, GR; Maas, DL; Sonnenberg, GE, 1997)
"Obesity is associated with diabetes, and leptin is known to be elevated in obesity."( Bailey, CJ; Bloom, SR; Gardiner, JV; Ghatei, MA; Hurley, JD; Kulkarni, RN; Smith, DM; Wang, RM; Wang, ZL; Withers, DJ, 1997)
"Although obesity is characterized by increased sympathetic nervous system activity, there is often a paradoxical reduction in cardiovascular end-organ response to sympathetic stimulation."( Carroll, JF; Cockrell, K; Hester, RL; Jones, AE; Mizelle, HL; Reinhart, GA, 1997)
"Furthermore, obesity is considered the main risk factor for cholesterol gallstone disease."( Cobos, E; Méndez-Sánchez, N; Roldán-Valadez, E; Tanimoto, MA; Uribe, M, 1997)
"Trends of obesity are documented; and young white girls are continuing to use tobacco, more so than boys and black girls."( Berenson, GS; Johnson, CC; Myers, L; Nicklas, TA; O'Neil, CE, 1997)
"Obesity is a multifactorial and complex affectation that is characterized by a long-term excess energy intake (EI) above energy expenditure (EE)."( Doucet, E; Tremblay, A, 1997)
"Obesity is a chronic disease, which similar to diabetes and hypertension, requires long-term treatment."( Aronne, LJ, 1998)
"Obesity is associated with blunted GH secretion, unfavorable body composition, and increased cardiovascular mortality."( Bengtsson, BA; Boseaus, I; Cerchio, K; Gertz, B; Jansson, JO; Krupa, D; Lönn, L; Murphy, G; Polvino, W; Sjöström, L; Svensson, J; Wyss, D, 1998)
"Thus, obesity is associated not only with higher leptin levels but also with blunted diurnal excursions and dampened pulsatility."( Boyadjian, R; Jinagouda, SD; Khan, A; Michael, R; Riad-Gabriel, MG; Saad, MF; Sharma, A; Steil, GM, 1998)
"Obesity is above the Health of the Nation targets in all ethnic groups, particularly in women of African descent."( Atkinson, RW; Cappuccio, FP; Cook, DG; Strazzullo, P, 1997)
"Since obesity is a chronic condition, further studies should be conducted to evaluate the long-term safety and efficacy of these agents and the role of combination therapy using different modalities."( Cerulli, J; Lomaestro, BM; Malone, M, 1998)
"Obesity is associated with increased activity of the sympathetic nervous system."( Haynes, WG; Mark, AL; Morgan, DA; Sivitz, WI; Walsh, SA, 1998)
"Human obesity is a complex disorder, with many factors playing a part; the pathophysiology of leptin is not as simple as it seems to be in rodent models of obesity."( Auwerx, J; Staels, B, 1998)
"NIDDM and obesity are characterized by decreased insulin-stimulated glucose uptake in muscle."( Ardehali, H; DeFronzo, RA; Granner, D; Iozzo, P; Koval, J; Mandarino, LJ; Pendergrass, M; Pipek, R; Printz, R; Vogt, C; Yki-Jarvinen, H, 1998)
"1."( Acosta, A; Albornoz, MA; Baptista, T; Contreras, Q; de Quijada, M; Hernández, L; LaCruz, A; Páez, X; Teneud, L, 1998)
"Obesity is an increasingly prevalent and important health problem."( Burn, P; Campfield, LA; Smith, FJ, 1998)
"Upper body obesity is a risk factor for type 2 diabetes."( Arner, P; Eriksson, P; Hoffstedt, J; Lönnqvist, F; Reynisdottir, S; Thörne, A; Van Harmelen, V, 1998)
"Obesity is a first-order problem, not only because of its high prevalence and the greater frequency of the male type, but because of the high prevalence of cardiovascular risk factors in obese people."( Carratalá Pérez, M; Fernández-Cañadas Sánchez, JM; Molina Maciá, M; Sánchez García, JI; Server Romero, L; Valencia Valencia, P, 1998)
"Obesity is a highly prevalent pathology in this province and increases with age."( Artigao, LM; Divisón, JA; García Gosálvez, F; López Abril, J; Naharro, F; Puras, A; Rodríguez Paños, B; Sanchís, C, 1998)
"Obesity is a disease which severely affects health associated to an increase in relative mortality."( Arteaga, A; Rozowski, J, 1997)
"Obesity is associated with increased leptin levels, and several hormones, including insulin and glucocorticoids, have been associated with leptin levels and expression in rodents."( Doulgerakis, DE; Flier, JS; Griveas, I; Kaklamani, VG; Liolios, AD; Mantzoros, CS; Moses, AC; Tritos, NA, 1998)
"Abdominal obesity is associated with insulin resistance and cardiovascular risk factors, but there has been little information published to advance the use of abdominal anthropometry in the care of diabetic patients."( Dunbar, VG; Kahn, HS; Phillips, LS; Ziemer, DC, 1998)
"Obesity is associated with an increased incidence of insulin resistance, dyslipoproteinemia, and hypercoagulability."( Berg, A; Halle, M; Keul, J; Northoff, H, 1998)
"Obesity is a concern in the long-term management of patients following liver transplantation, yet the risk of obesity and the factors that influence its development have not been well defined."( Everhart, JE; Hoofnagle, JH; Lake, JR; Lombardero, M; Wiesner, RH; Zetterman, RK, 1998)
"Second, obesity is associated with poorer self-rated health, high blood pressure, heart disease, diabetes, arthritis, respiratory and stomach problems."( Cairney, J; Wade, TJ, 1998)
"Obesity is a metabolic disorder in which multiple clinical and biochemical alterations coexist."( Albarrán, OG; García-Robles, R; Rábano, A; Ruilope, LM; Villa, E, 1998)
"Obesity is linked to functional brown adipose tissue (BAT) atrophy, partially due to adipocyte apoptosis."( Briscini, L; Carruba, MO; Dioni, L; Nisoli, E; Tonello, C, 1998)
"Obesity is an important risk factor for type 2 diabetes."( Canovatchel, W; Chung, J; Comstock, J; Crockett, SE; Elbein, SC; Hauptman, J; Hirsch, IB; Hollander, PA; Kaplan, RA; Kelley, D; Lodewick, PA; Lucas, CP; McGill, J; Taylor, T; Weiss, SR, 1998)
"Obesity is increasing at an alarming rate."( Borrell, L; Foreyt, JP; Haddock, CK; Poston, WS, 1998)
"Because obesity is a risk factor for numerous medical disorders and excess mortality, it is imperative that effective treatments be developed."( Borrell, L; Foreyt, JP; Haddock, CK; Poston, WS, 1998)
"Obesity is at present one of the most important health risk factors in developed countries."( Drbalová, K, 1998)
"We conclude that obesity is associated with greater BMD (4% at the lumbar spine; 11% at the hip) probably due to both greater physical stress and higher estrogen levels."( Aranda-Gallegos, JE; Mendoza-Torres, LJ; Murillo-Uribe, A; Ortíz-Luna, G; Río de la Loza-Cava, MF; Santos-González, J, 1998)
"Obesity is a disease with distinct genetic determination and its phenotype is defined by the still unknown number of genes whose expression can be influenced by environmental factors."( Bartek, J; Franková, M; Hrebícek, J; Hrubísková, L; Mohapl, P; Pastorková, R; Růzicka, V; Stejskal, D; Vávrová, J, 1997)
"Obesity is among the key promoters of a number of other highly prevalent and often fatal diseases."( Kurscheid, T; Lauterbach, K, 1998)
"Obesity is associated with increased morbidity and mortality."( de Leiva, A, 1998)
"Obesity is characterised by pathophysiological defects affecting both sides of the energy balance equation."( Astrup, A; Lundsgaard, C, 1998)
"Genetic obesity is associated with increased neuropeptide Y (NPY) messenger RNA (mRNA) and decreased POMC mRNA in the hypothalamus of ob/ob and db/db mice, or impaired sensitivity to alphaMSH (derived from POMC) in the yellow agouti mouse."( Bergen, HT; Mizuno, TM; Mobbs, CV; Taylor, J, 1998)
"The rate of obesity is higher in female than in male (P < 0."( Hua, Q; Tang, Z, 1997)
"Obesity is associated with insulin resistance and other major cardiovascular risk factors."( Breban, D; Hell, E; Krempler, F; Patsch, W; Winkler, C, 1998)
"Obesity is characterized by variable degrees of hyperinsulinaemia, which has been attributed to either beta-cell hypersecretion or reduced hepatic insulin extraction, or both."( Bessone, A; Cavallo-Perin, P; Cerutti, F; Pacini, G; Rabbone, I; Sacchetti, C, 1998)
"Obesity is associated with an increase in plasma leptin levels primarily derived from enhanced expression of the leptin gene in the adipose tissue."( Buison, A; Duanmu, Z; Dunbar, JC; Houck, C; Jen, KL; Lu, H, 1998)
"Second, obesity is not consistently associated with increased blood pressure, at least in rodent models."( Correia, M; Haynes, WG; Mark, AL; Morgan, DA; Shaffer, RA, 1999)
"Obesity is a complex syndrome that involves defective signaling by a number of different factors that regulate appetite and energy homeostasis."( Dannenberg, AJ; Diehl, AM; Lee, FY; Li, Y; Lin, HZ; Trush, MA; Yang, EK; Yang, SQ, 1999)
"Obesity is common in polycythemic patients, and it is important to know how the various published normative ranges compare across a wide range of body weights."( Dupont, JO; Leslie, WD; Peterdy, AE, 1999)
"Obesity is a common confounding factor in the interpretation of red cell mass measurements."( Dupont, JO; Leslie, WD; Peterdy, AE, 1999)
"Obesity is an increasing health problem in most developed countries and its prevalence is also increasing in developing countries."( Uusitupa, M, 1999)
"Human obesity is the result of both environmental and genetic factors."( Gautier, JF; Ravussin, E, 1999)
"Abdominal obesity is connoted by hyperinsulinism and insulin insensitivity, a trend toward glucose intolerance, hypoactivity of GH/IGF-I axis and alterations of hypothalamo-pituitary-adrenal (HPA) axis."( Avogadri, E; Ganzaroli, C; Gauna, C; Ghigo, E; Grottoli, S; Maccario, M; Oleandri, SE; Procopio, M; Rossetto, R, 1999)
"Obesity is a serious health problem in the Western societies, therefore its treatment has become the subject of intense interest in the scientific community."( Fathi, Z; Poindexter, GS; Zimanyi, IA, 1998)
"Central (abdominal) obesity is much more strongly associated with insulin resistance than overall obesity."( Kotake, H; Oikawa, S, 1999)
"Obesity is a major health problem in western societies."( Fritze, J, 1999)
"Human obesity is usually associated with high rates of energy expenditure."( Jéquier, E; Tappy, L, 1999)
"Obesity is becoming more frequent in children; understanding the extent to which this condition affects not only carbohydrate and lipid metabolism but also protein metabolism is of paramount importance."( Maffeis, C; Rueda-Maza, CM; Schutz, Y; Zaffanello, M, 1999)
"Obesity is associated with an increased risk for all cause mortality especially coronary heart disease (CHD)."( Kawakubo, K; Lee, JS, 1999)
"Central or visceral obesity is recognized as a main risk factor for cardiovascular disease and type 2 diabetes mellitus."( Arver, S; Mårin, P, 1998)
"Obesity is a rapidly increasing health problem among US youth."( Blecker, U; Escobar, O; Hilton, C; Mizuma, H; Sothern, MS; Suskind, RM; Udall, JN; Vargas, A, 1999)
"Obesity is a complex disease with multiple features that has confounded efforts to unravel its pathophysiology."( El-Bershawi, A; Guven, S; Hoffmann, RG; Kissebah, AH; Krakower, GR; Sonnenberg, GE; Wilson, CR, 1999)
"Obesity is associated with an increased risk of alveolar hypoventilation and carbon dioxide retention, suggesting that abnormalities in chemoreflex control mechanisms may be implicated."( Kato, M; Narkiewicz, K; Pesek, CA; Somers, VK, 1999)
"Obesity is frequently associated with insulin resistance."( Fuchs, D; Ledochowski, M; Murr, C; Widner, B, 1999)
"Obesity is associated with a cluster of abnormalities, including hypertension, insulin resistance, hyperinsulinemia, and elevated levels of both plasminogen activator inhibitor 1 (PAI-1) and transforming growth factor beta (TGF-beta)."( Hotamisligil, GS; Loskutoff, DJ; Pandey, M; Samad, F; Uysal, KT; Wiesbrock, SM, 1999)
"Overweight and obesity is a prevalent and costly threat to public health."( Abbot, NC; Ernst, E; Harkness, EF; Pittler, MH, 1999)
"Obesity is associated with blunted GH secretion and an unfavorable lipoprotein pattern."( Bengtsson, BA; Jansson, JO; Johannsson, G; Ottosson, M; Svensson, J; Taskinen, MR; Wiklund, O, 1999)
"Obesity is influenced by a variety of factors including host, dietary and management factors and these must be considered when developing weight control programmes for cats."( Robertson, ID, 1999)
"Human obesity is associated with insulin resistance, hyperinsulinemia, and a predisposition to hypertension and vascular disease, the origin of which may lie in impairment of endothelial function."( Buckingham, RE; Chattington, PD; Walker, AB; Williams, G, 1999)
"Obesity is associated with a high mortality rate, multiple chronic medical conditions, and carries an enormous financial burden."( Carek, PJ; Dickerson, LM, 1999)
"Obesity is a serious problem in the United States."( Riley, RE, 1999)
"Obesity is associated with elevated levels of serum leptin while undernutrition and fasting lead to low leptin."( Astorga, R; Casanueva, FF; Cordido, F; Dieguez, C; Garcia-Mayor, RV; Pombo, CM; Pombo, M; Popovic, V, 1999)
"Obesity is a major risk factor for the development of type 2 diabetes and is an important obstacle to the management of this disease."( Williams, G, 1999)
"Obesity is emerging in the Third World, first in urban middle-aged women."( James, WP; Ralph, A, 1999)
"The effect of obesity is minimized if patients are dosed based on ideal body weight."( Caldwell, JE; Fisher, DM; Hsu, J; Lennon, RL; Reynolds, KS; Schmith, VD; Sokoll, MD, 1999)
"Obesity is commonly associated with elevated plasma free fatty acid (FFA) levels, as well as with insulin resistance and hyperinsulinemia, two important cardiovascular risk factors."( Boden, G; Rocha, DM; Santomauro, AT; Santos, RF; Silva, ME; Strassmann, PG; Ursich, MJ; Wajchenberg, BL, 1999)
"Treatments for obesity are disappointing."( , 1999)
"Obesity is associated to a variety of endocrine abnormalities that might lead to chronic anovulation in women."( Gallardo Lozano, E; Gutiérrez Gutiérrez, AM; Hernández García, IA, 1999)
"Obesity is a classical feature of patients with Gs deficiency, but the mechanism leading to fat accumulation has not been elucidated."( Adnot, P; Bougnères, P; Carel, JC; Chaussain, JL; Condamine, L; Garabédian, M; Le Stunff, C; Mallet, E, 1999)
"Visceral obesity is a strong predictor of type 2 (non-insulin-dependent) diabetes and is associated with insulin resistance."( Björntorp, P; Rosmond, R, 1999)
"Obesity is associated with a decrease in growth hormone (GH) and reversible with weight loss."( Albero Gamboa, R; Guallar Labrador, AM; Sanz París, A, 1999)
"Obesity is a significant risk factor for hypertension and the cardiovascular sequelae of hypertension."( Adair, CT; Anderson, DC; Cameron, ME; Jones, DW; King, NS; Miller, ME; Willoughby, DL; Wofford, MR, 1999)
"However, obesity is associated with an increased prevalence of anatomic LVH, making more accurate ECG criteria in obese patients a clinical priority."( Dahlöf, B; Devereux, RB; Jern, S; Kjeldsen, SE; Okin, PM, 2000)
"Thus, obesity is associated with the activation of renal ACE in vivo independent of its mRNA expression and enhanced vascular contractility to angiotensin II."( Barton, M; Carmona, R; d'Uscio, LV; Goettsch, W; Haudenschild, CC; Hillen, H; Krieger, JE; Lattmann, T; Lüscher, TF; Morawietz, H; Münter, K; Shaw, S, 2000)
"Obesity is often accompanied by a decreased ability of insulin to stimulate glucose uptake and glycogenesis in skeletal muscle."( Heerschap, A; Smits, P; Tack, CJ; Van Den Bergh, AJ; Van Den Boogert, HJ; Vervoort, G, 2000)
"Obesity is a prevalent disorder that increases the risk for premature cardiovascular disease."( Breban, D; Esterbauer, H; Hell, E; Krempler, F; Oberkofler, H; Patsch, W; Paulweber, B, 2000)
"Obesity is a disease responsible for many serious complications."( Ricquier, D, 1999)
"Obesity is a multifactorial syndrome characterized by an excessive adipose tissue accumulation, and is associated with acquired insulin resistance."( Hamaguchi, T; Hanafusa, T; Matsuzawa, Y; Nakajima, H, 2000)
"Obesity is a risk factor for recurrent stones as it is for primary stones."( Carrilho-Ribeiro, L; de Moura, MC; Pinto-Correia, A; Velosa, J, 2000)
"Obesity is associated with catecholamine resistance with a relatively ineffective lipolysis in fat cells, and presence of a family history of obesity was not associated with a further suppression of lipolysis."( Hellström, L; Reynisdottir, S, 2000)
"Obesity is a multifactorial disease combining the effects of genetic predisposition with very powerful environmental risk factors."( Clément, K; Froguel, P; Guy-Grand, B, 2000)
"Abdominal obesity is associated with hyper-responsiveness of the hypothalamic-pituitary-adrenocortical (HPA) axis to stimulatory neuropeptides and to stress."( Calzoni, F; Ceroni, L; Cortelli, P; Gambineri, A; Gnudi, U; Menozzi, R; Pasquali, R; Rio, GD; Sinisi, R; Vicennati, V, 2000)
"Childhood obesity is associated with several abnormalities of the GH axis, including decreased spontaneous secretion, decreased response to exogenous secretagogues, and altered pulsatile pattern of secretion."( Danielsson, P; Elimam, A; Kamel, A; Marcus, C; Norgren, S, 2000)
"Obesity is commonly associated with high rates of cardiovascular disease (CVD)."( Clifton, PM; Heilbronn, LK; Kind, KL; Morris, AM; Noakes, M, 2000)
"Obesity is a more potent cardiovascular risk factor (CVRF) in men than in women."( Baron, AD; Cronin, J; Crowde, K; Hempfling, A; Hook, G; Paradisi, G; Steinberg, HO, 2000)
"The prevalence of obesity is higher in black than in white women."( Darnell, BE; Goran, MI; Hunter, GR; Larson, DE; Newcomer, BR; Redden, DT; Weinsier, RL; Zuckerman, PA, 2000)
"Obesity is associated with increased incidence of cardiovascular diseases, insulin resistance, dyslipoproteinemia and cancer."( Miczke, A; Pupek-Musialik, D, 2000)
"Childhood obesity is a complex syndrome, probably due to the multiplicity of contributing factors, contradictory literature information about etiology, prognosis, prevention and treatment."( Evereklioglu, C; Karabiber, H; Mungen, B; Tayfun, M; Yakinci, C, 2000)
"The pathogenesis of obesity is complex and miscellaneous endogenous as well exogenous factors modulate body weight."( Suter, PM; Vetter, W, 2000)
"Obesity is the most common cause of human essential hypertension in most industrialized countries."( Brands, MW; Fitzgerald, S; Hall, JE; Hildebrandt, DA; Kuo, J, 2000)
"Obesity is worldwide one of today's most important medical and public health problems."( Nordmann, A, 2000)
"Obesity is associated with physiological changes that can alter the pharmacokinetic parameters of many drugs."( Bearden, DT; Rodvold, KA, 2000)
"By definition, obesity is a result of a positive energy balance, which usually amounts to a tiny proportion of the total energy turnover."( Sørensen, TI, 2000)
"Childhood obesity is becoming a global epidemic."( Farooqi, IS; O'Rahilly, S, 2000)
"Central obesity is a powerful predictor for disease."( Björntorp, P; Rosmond, R, 2000)
"Obesity is a highly prevalent medical condition and is commonly accompanied by hypertension."( Fujioka, K; Johnson, F; McMahon, FG; Mendel, CM; Mooradian, AD; Rolston, K; Rowe, E; Singh, BN, 2000)
"Marked obesity is an independent risk factor for multi-system morbidity."( Goldstein, SE; Levy, Y; Shoenfeld, Y, 1998)
"Obesity is one of the most common medical problems in the United States and a risk factor for illnesses such as hypertension, diabetes, degenerative arthritis and myocardial infarction."( Berke, EM; Morden, NE, 2000)
"Obesity is an extremely challenging medical condition because it is a multifactorial disease that lies at the interface between the biology of body energy regulation and an environment (physical and sensory) that has been increasingly characterized as 'hostile to good health'."( Campfield, LA; Smith, FJ, 1999)
"Abdominal/visceral obesity is associated with blunted growth hormone (GH) secretion and an unfavourable lipoprotein pattern."( Bengtsson, BA; Johannsson, G; Svensson, J; Taskinen, MR; Wiklund, O, 2000)
"Android obesity is linked with an increased cardiovascular mortality and with type 2 diabetes mellitis, thus calling for an early management of this disease."( Björntorp, P, 2000)
"If obesity is regarded as an excess of body fat and not as an excess of weight (increased BMI), the cut-off points for obesity in Singapore based on the BMI would need to be lowered."( Deurenberg, P; Deurenberg-Yap, M; Schmidt, G; van Staveren, WA, 2000)
"Obesity is associated with vitamin D insufficiency and secondary hyperparathyroidism."( Chen, TC; Holick, MF; Lu, Z; Matsuoka, LY; Wortsman, J, 2000)
"Obesity is a common but highly complex disease, which evolved from interactions of multiple genes and the environment."( Lee, YS; Loke, KY, 2000)
"Obesity is unlikely to be caused by a single gene defect unless it is extreme (body mass index > 60), or present in an isolated population group."( Lee, YS; Loke, KY, 2000)
"Obesity is an important factor predisposing to type 2 diabetes mellitus, especially for postmenopausal women."( Bidzińska, B; Mikulski, E; Milewicz, A, 2000)
"Obesity is a major health concern and may cause hyperestrogenism."( Keeney, GL; Li, H; Webb, MJ; Zanetta, GM, 2000)
"Obesity is a major global public health problem."( Ballmer, PE; Imoberdorf, R, 2000)
"Cortisol in obesity is a much-studied problem."( Björntorp, P; Rosmond, R, 2000)
"Obesity is epidemic and dangerous."( Weiss, D, 2000)
"Obesity is a major factor impairing postoperative oxygenation."( Ishikawa, S; Morishita, Y; Ohki, S; Ohtaki, A; Takahashi, T; Yamagishi, T, 2000)
"Obesity is a major health care problem and is associated with significant cardiovascular morbidity."( Berkowitz, DE; Brooks-Asplund, E; Kim, S; Li, D; Mo, Z; Nyhan, D; Shoukas, A; Winters, B, 2000)
"The prevalence of obesity is increasing in westernized societies."( Schrauwen, P; Westerterp, KR, 2000)
"Obesity is a major public health problem in Western countries, and >55% of adult Americans are overweight or obese."( Kim, S; Moustaid-Moussa, N, 2000)
"Visceral obesity is associated with resistance to the antilipolytic effect of insulin in vivo."( Albu, JB; Fried, SK; Johnson, JA; Pi-Sunyer, FX, 2001)
"Obesity is associated with an increased risk for various diseases, most notably, hypertension, diabetes mellitus, dyslipidemia, and coronary heart disease (CHD)."( Jones, PH, 2000)
"In men, extreme obesity is associated with low serum testosterone (T) and high estrogen [estrone and estradiol (E(2))] levels."( Castro-Fernández, C; López-Alvarenga, JC; Méndez, JP; Olivares, A; Söderlund, D; Ulloa-Aguirre, A; Veldhuis, JD; Zambrano, E, 2000)
"In humans, obesity is also associated with an increase in insulin resistance and the development of Type II diabetes, however, contrary to rats and mice, there is abundance of leptin, indicating a state of resistance to this hormone in humans."( Ceddia, RB; Curi, R; William, WN, 2001)
"Obesity is a complex disease resulting from the interaction between a variety of genetic and environmental factors."( Pérusse, L, 2000)
"Obesity is a multifactoral condition."( Froguel, P, 2000)
"Obesity is the predominant factor leading to insulin resistance, although other factors play a role."( Grundy, SM, 2000)
"Upper body obesity is associated with metabolic syndrome X."( Daubresse, JC, 2000)
"Obesity is one of the pathologies with ever-increasing prevalence in modern societies."( Czupryniak, L; Drzewoski, J, 2000)
"Obesity is a common problem in western society that is directly linked to several disease processes and is associated with significant morbidity and mortality."( Bradley, RL; Cheatham, B; Cleveland, KA, 2001)
"Obesity is associated with the occurrence of hypertension; however, the mechanisms of obesity-induced high blood pressure (BP) remain unclear."( Chu, NF; Shieh, SM; Wang, DJ, 2001)
"Obesity is positively associated with BP among school children in Taiwan; however, the role of plasma leptin on the development of obesity-related hypertension is still controversial among school children."( Chu, NF; Shieh, SM; Wang, DJ, 2001)
"Obesity is a common health disorder in humans and is inherited genetically."( Das, UN; Suresh, Y, 1998)
"Obesity is a health problem in the majority of the developed countries and is emerging as a serious problem in the developing countries."( Akhtar, S; Bashir, MI; Khan, AK; Laway, BA; Masoodi, SR; Wani, AI; Zargar, AH, 2000)
"We conclude that obesity is a growing problem even in developing regions like ours."( Akhtar, S; Bashir, MI; Khan, AK; Laway, BA; Masoodi, SR; Wani, AI; Zargar, AH, 2000)
"Obesity is often associated with a reduced ventilatory response and a decreased maximal exercise capacity."( Farkas, GA; Lee, SD; Nakano, H, 2001)
"Obesity is highly prevalent in industralized countries and is increasing worldwide."( Ahima, RS; Osei, SY, 2001)
"Obesity is often accompanied with hypertension and increases cardiovascular events."( Hano, T; Nishio, I, 2001)
"Obesity is associated with an increased risk of co-morbidity, including cardiovascular disease and diabetes."( Mather, L; O'Meara, S; Riemsma, R; Shirran, L; ter Riet, G, 2001)
"Obesity is prevalent in this breast cancer population."( Bjarnason, GA; Franssen, E; Madarnas, Y; Sawka, CA, 2001)
"Human obesity is associated with elevated plasma leptin levels."( Cohen, DE; Nguyen, LB; Ranginani, N; Rossetti, L; Shefer, S; VanPatten, S, 2001)
"As obesity is the most common chronic disorder in the industrialized societies, its impact on individual lives as well as on health economics has to be recognized more widely."( Bennek, J; Galler, A; Kiess, W; Kratzsch, J; Meyer, K; Müller, G; Reich, A, 2001)
"Obesity is related to cardiovascular disease (CVD) morbidity and mortality, however, the mechanisms for the development of obesity-induced CVD risk remain unclear."( Chu, NF; Hotamisligil, GS; Rifai, N; Rimm, EB; Spiegelman, D; Stampfer, M, 2001)
"Obesity is a chronic disease and requires ongoing treatment."( Greenway, F, 1999)
"Abdominal obesity is strongly related to metabolic disorders."( Berglund, L; Risérus, U; Vessby, B, 2001)
"(1) Treatments for obesity are disappointing."( , 1999)
"Obesity is characterized by dislipoproteinaemia with increased cholesterol and triacylglycerol levels and lower chylomicra disposal rates."( Alemany, M; Blay, M; Fernández-López, JA; Julve, J; Peinado-Onsurbe, J; Remesar, X; Rodríguez, V, 2001)
"Obesity is a growing public health problem worldwide."( Mooradian, AD, 2001)
"Obesity is a multifactorial condition."( Boutin, P; Froguel, P, 2001)
"Obesity is currently considered as a chronic metabolic disease, associated with a high risk of cardiovascular complications."( Bourikas, D; Kaloyianni, M; Koliakos, G; Konstantinou-Tegou, A, 2001)
"Obesity is associated with insulin resistance."( Frayn, KN, 2001)
"Obesity is known to predispose to sleep-related breathing disorders."( Bachour, A; Laitinen, LA; Maasilta, P; Polo, O; Teramo, K, 2001)
"Obesity is a risk factor for many chronic diseases, including glucose intolerance, lipid disorders, hypertension, and coronary heart disease."( Arnett, DK; Borecki, IB; Feitosa, MF; Leppert, M; Myers, RH; Province, MA; Rich, SS; Sholinsky, P, 2002)
"Obesity is associated with increased cardiovascular morbidity and mortality and with elevated circulating levels of the satiety factor leptin."( Konstantinides, S; Koschnick, S; Loskutoff, DJ; Schäfer, K, 2001)
"A pandemic of obesity is contributing importantly to the prevalence of the metabolic syndrome characterized by hypertension, insulin resistance, and hyperlipidemia."( Dubey, RK; Jackson, EK; Tofovic, SP, 2001)
"Obesity is associated with insulin resistance and hyperinsulinemia, and administration of insulin to lean mice induced TF mRNA in the kidney, brain, lung, and adipose tissue."( Loskutoff, DJ; Pandey, M; Samad, F, 2001)
"Android obesity is associated with increased cortisol secretion."( Khani, S; Tayek, JA, 2001)
"This obesity is also characterised by alterations of the beta-adrenergic signaling pathway."( Adli, H; Bazin, R; Diot-Dupuy, F; Ferré, P; Mory, G; Wiel, M, 2001)
"Obesity is associated with a significant increase in long-term mortality, mostly as a result of cardiovascular events."( Nair, S; Thuluvath, PJ; Verma, S, 2002)
"Human obesity is associated with leptin resistance, elevated leptin levels in the circulation, and increased risk of arterial and venous thrombotic disease."( Konstantinides, S; Loskutoff, DJ; Schafer, K, 2001)
"Obesity is associated with an extended hospitalization time in subjects with acute pancreatitis."( Blomgren, KB; Steineck, G; Sundström, A; Wiholm, BE, 2002)
"Obesity is a common condition in type 2 diabetic patients."( Annemans, L; Lamotte, M; Lefever, A; Masure, J; Nechelput, M, 2002)
"Obesity is frequently associated with excess caloric fat dietary intake, especially in the form of fatty acids."( Camejo, G; Ljung, B; Oakes, N, 2001)
"However, obesity is associated with leptin resistance, since high circulating levels of leptin were observed in obese subjects."( Haynes, WG; Mark, AL; Rahmouni, K, 2002)
"Obesity is associated with insulin resistance, particularly when body fat has a central distribution."( Boyko, EJ; Carr, DR; Cnop, M; Havel, PJ; Hull, RL; Kahn, SE; Knopp, RH; Knowles, NG; Landchild, MJ; Retzlaff, BM; Vidal, J; Walden, CE; Wang, F, 2002)
"Obesity is associated with risk factors for cardiovascular disease, including insulin resistance, and can lead to cardiac hypertrophy and congestive heart failure."( Buckingham, RE; Clarke, K; Cole, MA; Desrois, M; Draper, NJ; Sidell, RJ, 2002)
"Obesity is a common nutritional problem often associated with diabetes, insulin resistance, and fatty liver (excess fat deposition in liver)."( Amemiya-Kudo, M; Gotoda, T; Harada, K; Hasty, AH; Ide, T; Iizuka, Y; Ishibashi, S; Matsuzaka, T; Nagai, R; Ohashi, K; Okazaki, H; Osuga, J; Shimano, H; Tamura, Y; Tomita, S; Yahagi, N; Yamada, N; Yoshikawa, T, 2002)
"Overweight or obesity is strongly associated with comorbidities such as type 2 diabetes mellitus, hypertension, heart disease, gall bladder disease, and sleep apnea."( Bell, SJ; Goodrick, GK, 2002)
"Measurement of obesity is not as simple as its definition."( Moyad, MA, 2002)
"Obesity is a typical example of a complex multifactorial disease arising from behavioural, environmental and genetic factors that may affect individual responses to dietary intake and physical activity."( Di, TR; Marotta, A; Miraglia, del GE; Nobili, B; Perrone, L; Santoro, N, 2002)
"Common obesity is primarily characterized by resistance to the actions of the hormone leptin."( Chaubey, VP; Cheng, A; Kennedy, BP; Lee-Loy, A; McGlade, CJ; Simoncic, PD; Tremblay, ML; Uetani, N, 2002)
"Abdominal obesity is an independent risk factor for coronary heart disease in middle-aged men and even more important than overall obesity."( Lakka, HM; Lakka, TA; Salonen, JT; Tuomilehto, J, 2002)
"Obesity is commonly associated with a high incidence and prevalence of dyslipidaemia, cardiovascular disease and Type II diabetes."( Calder, AG; Duthie, GG; Elia, M; Faber, P; Gibney, ER; Johnstone, AM; Lobley, GE; Stubbs, RJ, 2002)
"Obesity is a state of relative leptin resistance, and obesity in childhood is associated with an increased incidence of type 2 diabetes in later life."( Malee, MP; Messerlian, G; Tucker, R; Verma, A; Vohr, BR, 2002)
"Morbid obesity is the result of massive expansion of white adipose tissue (WAT) and requires recruitment of adipocyte precursor cells and their supporting infrastructure."( Li, J; Pan, W; Unger, RH; Yu, X, 2002)
"Obesity is pathogenically related to clinical and subclinical disorders that contribute to the development of atherosclerotic plaques and their complications leading to onset of cardiovascular events."( Coker, M; Darcan, S; Gökşen, D; Güven, H; Levent, E; Mahmut, C; Ozyürek, AR; Parlar, A, 2002)
"Obesity is a risk factor triggering a variety of metabolic diseases."( Chen, Y; Ono, F; Yoshida, T; Yoshikawa, Y, 2002)
"Among preschoolers, obesity is now 10% while in 6-year-old children it is 17."( Albala, C; Kain, J; Uauy, R; Vio, F, 2002)
"In human subjects, obesity is in general associated with elevated serum leptin levels, suggesting decreased sensitivity to leptin."( Isojärvi, JI; Knip, M; Kotila, M; Pakarinen, A; Pylvänen, V; Turkka, J, 2002)
"Because obesity is associated with high leptin concentrations relative to fat mass, programming of leptin concentrations may be one mechanism by which early nutrition influences later obesity."( Cole, TJ; Farooqi, IS; Fewtrell, M; Lucas, A; O'Rahilly, S; Singhal, A, 2002)
"Obesity is a risk factor of breast cancers."( Dieudonne, MN; Giudicelli, Y; Leneveu, MC; Machinal-Quelin, F; Pecquery, R; Serazin-Leroy, V, 2002)
"untreated obesity is also associated with low GH levels; however, levels of IGF-1 are normal."( Douyon, L; Schteingart, DE, 2002)
"Obesity is a risk for type II diabetes mellitus and increased vascular resistance."( Bohlen, HG; Nase, GP, 2002)
"Male obesity is associated with increased serum Mg, P, PTH and urinary P and lower supine aldosterone and 25OHD, but unchanged serum and urinary Ca."( Bolu, E; Durmus, O; Erdogan, M; Ozata, M; Ozdemir, IC; Yilmaz, MI, 2002)
"Obesity is a morbid condition with hemodynamic consequences affecting the systemic and pulmonary circulations leading to a risk of pulmonary hypertension."( Humbert, M; Ioos, V; Parent, F; Simonneau, G; Sitbon, O; Sztrymf, B, 2002)
"Obesity is a major public health concern in the United States and its prevalence is increasing."( Buysse, DJ; Fagiolini, A; Frank, E; Houck, PR; Kupfer, DJ; Mallinger, AG; Ombao, H; Swartz, HA, 2002)
"Obesity is associated with increased risk for cardiovascular diseases and peripheral endothelial dysfunction."( Kalliokoski, K; Knuuti, J; Laine, H; Luotolahti, M; Nuutila, P; Raitakari, O; Sundell, J, 2002)
"Obesity is known to be closely associated with insulin resistance, hyperleptinemia, and obstructive sleep apnea (OSA)."( Ficker, JH; Fuchs, FS; Hahn, EG; Harsch, IA; Konturek, PC; Lohmann, T; Schahin, SP, 2002)
"Obesity is chronic, requires chronic treatment, its incidence is increasing and it has few effective treatments."( Greenway, FL, 2001)
"Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers."( Crowley, VE; O'Rahilly, S; Yeo, GS, 2002)
"Obesity is an issue that is increasingly affecting ageing men."( Pu, SJ; Tan, RS, 2002)
"Obesity is associated with hyperleptinemia and is also a risk factor for fibrosis and severity of fibrosis in several chronic liver diseases."( Farrell, GC; Leclercq, IA; Robertson, GR; Schriemer, R, 2002)
"Because obesity is an important determinant of serum levels of insulin and leptin (the product of the obesity gene Ob), we investigated the role of obesity and serum levels of insulin and leptin in benign prostatic hyperplasia (BPH) etiology."( Chokkalingam, AP; Dahle, SE; Deng, J; Gao, YT; Hsing, AW; Stanczyk, FZ, 2002)
"Obesity is associated with considerable morbidity and decreased life expectancy."( Sanders, TA; Taylor, D; Werneke, U, 2002)
"Obesity is important in the aetiology of type 2 diabetes, and presents a major barrier to its successful prevention and management."( Wilding, JP, 2002)
"Obesity is on the increase yet within the National Health Service (NHS) treatment approaches differ greatly and service is patchy."( Bovill-Taylor, C; Carter, L; Dornhorst, A; Frost, G; Lyons, F; Stuttard, J, 2002)
"Obesity is commonly associated with the development of insulin resistance and diabetes in humans and rodents."( Ceddia, RB; Koistinen, HA; Sweeney, G; Zierath, JR, 2002)
"Abdominal obesity is associated with reduced 24-h plasma GH concentrations."( Ackermans, MT; Arndt, JW; Buijs, MM; Burggraaf, J; Cohen, AF; Frölich, M; Langendonk, JG; Meinders, AE; Pijl, H; Romijn, JA; Sauerwein, HP; Schoemaker, RC, 2002)
"Abdominal obesity is associated with coronary risk although the causality is not well established."( Baraza, JC; Fardy, PS; Garaulet, M; Garcia-Prieto, MD; Pérez-Llamas, F; Tébar, FJ; Zamora, S, 2002)
"Later on, when obesity is fully established, the GLUT4 protein was reduced in SM, heart and WAT, and that may be involved in the insulin resistance present in this condition."( da Silva, JL; de Carvalho Papa, P; Machado, UF; Nunes, MT; Vargas, AM, 2002)
"Obesity is among the well-established risk factors for cardiovascular morbidity and mortality."( Ben-Amotz, A; Friedrich, I; Levy, Y; Reitman, A, 2002)
"Obesity is increasing in prevalence worldwide and in all age groups."( Crawford, L; Ferrell, WR; Greer, IA; Ramsay, JE; Sattar, N; Wallace, AM, 2002)
"Childhood obesity is an emerging health problem."( Cook, J; Farley, C; Ghibaudi, L; Hwa, JJ; van Heek, M, 2002)
"Obesity is the most common nutritional disorder in the United States."( Crook, ED; Dubbert, PM; Hall, JE; Jones, DW; Wofford, MR, 2002)
"Obesity is a risk factor for women in both pregnancy and contraception."( Seffert, P, 1985)
"Obesity is a general medical condition associated with an increase in morbidity and mortality."( Anghelescu, I; Klawe, C; Szegedi, A, 2002)
"As obesity is a common finding in diabetic individuals, and obesity has been linked to an increase in plasma angiotensinogen levels, we enrolled diabetic subjects with a wide range of body mass index (BMI) for this study."( Fisher, ND; Hollenberg, NK; Laffel, LM; Lansang, MC; Osei, SY; Price, DA, 2002)
"Obesity is associated with the increased risk of cardiovascular disease; however, mechanisms responsible for such an increase are not fully understood."( Dzienis-Straczkowska, S; Kinalska, I; Kowalska, I; Stêpieñ, A; Straczkowski, M; Szelachowska, M, 2002)
"Obesity is a major public health problem."( Fowler, JS; Volkow, ND; Wang, GJ, 2002)
"Obesity is frequently associated with type 2 diabetes."( Ebenbichler, C; Esterbauer, H; Krempler, F; Linnemayr, V; Miller, K; Oberkofler, H; Patsch, JR; Patsch, W; Weitgasser, R; Xie, M, 2002)
"Obesity is the prime risk factor for the development of type 2 diabetes."( Engeli, S; Gorzelniak, K; Janke, J; Luft, FC; Sharma, AM, 2002)
"Obesity is associated with clinical evidence of varicose veins independently from the influence of sex hormones in postmenopausal women and is not associated with venous capacitance."( Bellati, C; Berrino, F; Celentano, E; Ciardullo, AV; Cioffi, V; Iannuzzi, A; Iannuzzo, G; Panico, S; Rubba, P, 2002)
"Abdominal obesity is also a high risk factor for these diseases."( Ahlberg, AC; Akesson, HO; Björntorp, P; Holm, G; Ljung, T; McEwen, B; Rosmond, R, 2002)
"Obesity is a risk factor for breast cancer in postmenopausal women."( Cleary, MP; Hu, X; Juneja, SC; Maihle, NJ, 2002)
"Obesity is a major risk factor associated with a variety of human disorders."( Benkovic, SA; Miller, DB; O'Callaghan, JP; Sriram, K, 2002)
"Central obesity is associated with increased morbidity and mortality."( Bujalska, I; Hewison, M; Sinha, B; Stewart, PM; Tomlinson, JW, 2002)
"Obesity is associated with an impaired utilization of fat as a fuel during post-absorptive conditions, during beta-adrenergic stimulation and possibly during exercise, although the latter data are controversial."( Blaak, EE; Saris, WH, 2002)
"Obesity is associated with an increased risk for a wide variety of chronic health conditions."( Fernstrom, JD; Fernstrom, MH, 2002)
"Minocycline and obesity are recognized as precipitating factors in pseudotumor cerebri syndrome."( Cochener, B; Colin, J; Kling, F, 2002)
"Obesity is a major chronic health problem in adults."( Hanif, MW; Kumar, S, 2002)
"The study of obesity is one of the most active and fast moving area in the basic biomedical research."( Zhang, JF, 1998)
"Diet-induced obesity is known to cause peripheral insulin resistance in rodents."( Jacques, H; Lavigne, C; Marette, A; Tremblay, F, 2003)
"Obesity is correlated with a poorer outcome in patients with bipolar I disorder."( Fagiolini, A; Frank, E; Houck, PR; Kupfer, DJ; Novick, DM, 2003)
"Obesity is a heterogeneous condition of variable aetiology, generally associated with pathologies such as arterial hypertension, hyperlipidaemia, diabetes and cardiac disease."( Dabin, C; del C Gayol, M; Herńandez, GN; Rasia, ML, 2002)
"Obesity is associated with multiple alterations of the endocrine systems, including abnormal circulating blood hormone concentrations, due to changes in their pattern of secretion and/or metabolism, altered hormone transport, and/or action at the level of target tissues."( Gambineri, A; Pasquali, R; Vicennati, V, 2002)
"Furthermore, obesity is characterized by higher plasma concentrations of anti-thrombotic factors, such as tissue-type plasminogen activator (t-PA) and protein C, as compared to non-obese controls, the increase in these factors being likely to represent a protective response partly counteracting the increase in pro-thrombotic factors."( De Pergola, G; Pannacciulli, N, 2002)
"Obesity is a multi-factorial, chronic disorder that has reached epidemic proportions in most industrialized countries and is threatening to become a global epidemic."( Carruba, MO; Nisoli, E, 2002)
"Obesity is associated with high plasma levels of leptin, and leptin participates at the hypothalamic and pituitary levels in the regulation of GH secretion."( Casanueva, FF; Dieguez, C; Ozata, M, 2003)
"Actually, obesity is caused by many factors such as heredity, environment and food contents, among which hereditary gene seems to work as a key element."( Huang, ZY; Sun, ZJ, 2001)
"We conclude that obesity is characterized by insulin resistance of glucose uptake in resting skeletal muscle regardless of how glucose uptake is expressed."( Bergman, J; Bolli, GB; Hällsten, K; Kemppainen, J; Knuuti, J; Laine, H; Nuutila, P; Oikonen, V; Peltoniemi, P; Takala, T; Yki-Järvinen, H, 2003)
"The prevalence of obesity is rising at an alarming rate worldwide, with consequent increases in type 2 diabetes, hypertension and cardiovascular morbidity and mortality."( G Haynes, W; Rahmouni, K, 2002)
"Abdominal obesity is associated with a blunted lipolytic response to fasting that may contribute to the preservation of adipose tissue mass."( Buijs, MM; Burggraaf, J; Cohen, AF; de Kam, ML; Frölich, M; Meinders, AE; Pijl, H; Romijn, JA; Sauerwein, HP; Wijbrandts, C, 2003)
"Obesity is common, with a prevalence of 20-25% and may therefore have a considerable impact on the overall incidence of thrombosis."( Abdollahi, M; Cushman, M; Rosendaal, FR, 2003)
"Obesity is a problem of epidemic proportions that is associated with adverse cardiovascular outcomes."( Hamilton Dougherty, A; Okerberg, K, 2003)
"Obesity is a chronic disorder that is associated with significant co-morbidity and early mortality."( Gross, SB; Naqvi, TZ, 2003)
"Chronic obesity is associated with various cardiovascular disorders, including diabetes, dyslipidemia, and hypertension."( Chan, JC; Leung, WY; Thomas, GN; Tomlinson, B, 2003)
"Because obesity is thought to play a key role in atherosclerosis through the low-grade chronic inflammation, the present study was designed to investigate associations of body mass index (BMI), body fat, and weight gain with optimized inflammation markers in 1,053 residents who were 40 years of age and older from a rural community (total population = 3,940 in 2000) in Japan."( Inami, F; Saito, I; Yonemasu, K, 2003)
"Overweight and obesity are believed to be associated with renal damage."( de Jong, PE; de Zeeuw, D; Gans, RO; Janssen, WM; Navis, G; Pinto-Sietsma, SJ, 2003)
"Since obesity is associated with an increased cardiovascular risk, as well as with markedly elevated circulating leptin levels, we examined whether leptin has any pro-inflammatory effects on the function of monocytes."( Chicheportiche, R; Dayer, JM; Dreyer, M; Meier, CA, 2003)
"The prevalence of obesity is increasing."( D'Alessio, D; Rushing, PA; Seeley, RJ; Tso, P; Woods, SC, 2003)
"Obesity is an epidemic problem in the U."( Kane, JK; Konu, O; Li, MD, 2003)
"Obesity is associated with increased levels of inflammatory mediators."( Gottsäter, A; Lindgärde, F; Samuelsson, L, 2003)
"Adolescent obesity is becoming a national public health problem."( Berkowitz, RI; Cronquist, JL; Tershakovec, AM; Wadden, TA, 2003)
"At present, obesity is considered one of the major health problems."( Bláha, P; Srajer, J; Srámková, D, 2002)
"Obesity is a multifactorial syndrome influenced by both genetic and behavioral factors."( Arashiro, R; Fukuyama, S; Katsuren, K; Ohta, T, 2003)
"Obesity is actually accompanied by increased sympathetic nerve discharge to skeletal muscles, a main site for energy expenditure."( Eslami, P; Tuck, M, 2003)
"Obesity is an embodiment of a multifactorial problem with several intermediates in its casual pathway."( Myslobodsky, M, 2003)
"The fact that obesity is under strong genetic control has been well established."( Araujo, S; Deng, HW; Liu, YJ; Recker, RR, 2003)
"Hypothalamic obesity is a devastating complication in children surviving brain tumors and/or cranial irradiation."( Christensen, RK; Hinds, PS; Kaste, SC; Lensing, SY; Lustig, RH; Rai, SN; Ringwald-Smith, K; Schreiber, RE; Wu, S; Xiong, X, 2003)
"Obesity is responsible for inducing various metabolic diseases."( Chen, Y; Narita, H; Ogawa, H; Ohtoh, K; Yoshida, T; Yoshikawa, Y, 2003)
"As obesity is often associated with disregulation of glucose and insulin, we investigated the nature of glucose homeostasis in the obese pro-opiomelanocortin (POMC) knockout mouse."( Brennan, MB; Bui, S; Costa, JL; Forbes, S; Hochgeschwender, U; Reed, P, 2003)
"Visceral obesity is also associated with a hypercoagulate state and elevated concentrations of procoagulant factors such as factor VII."( Bergeron, J; Berthier, MT; Després, JP; Houde, A; Prud'homme, D; Vohl, MC, 2003)
"The prevalence of obesity is increasing alarmingly to epidemic proportions in children and adolescents, especially in industrialized countries."( Phillip, M; Shalitin, S, 2003)
"Obesity is a risk factor for the development of colon carcinoma."( Benson, AB; Catalano, PJ; Fuchs, CS; Haller, DG; Macdonald, JS; Mayer, RJ; Meyerhardt, JA, 2003)
"Obesity is another serious health problem and has been shown to be associated with prostate cancer."( Bub, JD; Iwamoto, Y; Onuma, M; Rummel, TL, 2003)
"Obesity is characterised by a marked insulin resistance which involves an abnormal regulation of K(+) uptake and metabolism."( Bolla, G; Fanari, P; Giacomotti, E; Longhini, E; Luzi, L; Palmulli, P; Salvadori, A; Tovaglieri, I, 2003)
"Obesity is a serious health problem throughout the world."( Bagchi, D; Bagchi, M; DiFerdinando, D; Preuss, HG, 2002)
"Obesity is a polygenic disorder that is associated with gallstone disease."( Nakeeb, A; Pitt, HA; Swartz-Basile, DA; Tran, KQ, 2003)
"Human obesity is associated with leptin resistance, elevated serum glucose and lipids, hepatic steatosis, and cholesterol gallstone formation."( Graewin, SJ; Nakeeb, A; Pitt, HA; Svatek, CL; Swartz-Basile, DA; Tran, KQ, 2003)
"Obesity is associated with both increased breast cancer risk and poorer prognosis after disease onset."( Dignam, JJ; Fisher, B; Johnson, KA; Mamounas, EP; Wieand, K; Xu, L, 2003)
"Obesity is a risk factor for several other disorders, including hypertension, diabetes, and coronary artery disease."( Beale, M; Schwartz, TL, 2003)
"Obesity is a multifactorial, chronic disorder that has reached epidemic proportions in most industrialised countries and is threatening to become a global epidemic."( Carruba, MO; Nisoli, E, 2003)
"Obesity is associated with many comorbid conditions including diabetes, hyperlipidemia, and gallstones."( Goldblatt, MI; Nakeeb, A; Pitt, HA; Svatek, C; Swartz-Basile, DA; Tran, KQ, 2003)
"Obesity is a chronic disease and its treatment needs long-life follow-up."( Brambilla, P; Maffeis, C; Salvatoni, A; Tanas, R; Trifirò, G, 2003)
"Overweight and obesity are frequently associated with increased plasma levels of aldosterone."( Barthel, A; Bornstein, SR; Ehrhart-Bornstein, M; Hauner, H; Lamounier-Zepter, V; Langenbach, J; McCann, SM; Scherbaum, WA; Schraven, A; Willenberg, HS, 2003)
"Human obesity is associated with elevated leptin levels and a high risk of death from cardiovascular disease."( Dellas, C; Goeschen, C; Halle, M; Konstantinides, S; Loskutoff, DJ; Pynn, M; Schäfer, K, 2004)
"Obesity is an increasing problem in several countries, leading to health problems."( Gobatto, CA; Mello, MA; Ribeiro, IA; Souza, CT, 2002)
"Obesity is a primary risk factor for the development of cardiovascular disease (CVD) and Type 2 diabetes, which are problematic in Hispanic adults."( Giltinan, KE; Grunwald, GK; Hill, JO; Jatkauskas, CJ; King, DL; Sharp, TA, 2003)
"Obesity is clearly associated with increased levels of the recently discovered hormone, leptin."( Moran, O; Phillip, M, 2003)
"Obesity is frequently associated with leptin resistance."( Adage, T; Kuipers, F; Ruffin, MP; Scheurink, AJ; Strubbe, JH; van Dijk, G, 2004)
"Obesity is a chronic disease resulting from various genetic factors and environmental conditions (nutrition, sedentary life-style, psychological factors)."( Keller, U; Stöckli, R, 2003)
"Obesity is an increasingly common condition and is associated with excess morbidity and mortality, including clinical and subclinical cardiac dysfunction."( Danias, PG; Kissinger, KV; Manning, WJ; Tritos, NA, 2004)
"Obesity is accompanied by a high incidence of atherosclerosis, arterial hypertension and non-insulin dependent diabetes mellitus in the pathogenesis of which is associated with oxygen-derived free radicals."( Birkner, E; Jochem, J; Polaniak, R; Rybus-Kalinowska, B; Zwirska-Korczala, K, 2003)
"Obesity is a major global public health problem."( Cetinkaya, A; Guven, A; Koksal, N; Ozdemir, R; Sokmen, G, 2004)
"Obesity is a risk factor for nonalcoholic steatohepatitis (NASH)."( Asghar, A; Chalasani, N; Considine, RV; Crabb, DW; Cummings, OW; Kwo, PY; Pandya, PK, 2003)
"Obesity is the result of a long-standing imbalance between energy intake and energy expenditure, aided by a complex biologic system that regulates appetite and favors intake."( Bessesen, DH, 2003)
"We conclude that obesity is associated with increased intramyocellular ceramide content."( Adams, JM; Berria, R; DeFronzo, RA; Mandarino, LJ; Pratipanawatr, T; Sullards, MC; Wang, E, 2004)
"Obesity is an important risk factor for heart failure in both women and men."( Cacciapuoti, F; Ciotola, M; Di Palo, C; Esposito, K; Giugliano, D; Giugliano, F; Labriola, D; Marfella, R; Misso, L; Siniscalchi, M, 2004)
"Severe obesity is associated with hypoventilation, a disorder that may adversely affect morbidity and mortality."( Burkart, KM; Fedorowicz, A; Gaudio, JC; Gonzales, R; Gozansky, WS; Nowbar, S; Taylor, MR; Zwillich, CW, 2004)
"Hypertension and obesity are common underlying disorders in patients with diastolic heart failure."( Bronzwaer, JG; Kamp, O; Smulders, YM; Stehouwer, CD, 2003)
"Obesity is an established risk factor for arthritis; however, the relationship between arthritis and obesity has not been well characterized at the population level in Wisconsin."( Chudy, N; Mehrotra, C; Thomas, V, 2003)
"Obesity is a chronic, complex, multifactorial disorder with increasing prevalence in modern society."( Aronne, LJ; Thearle, M, 2003)
"Obesity is characterized by increased plasma fatty acids and oxidative stress."( Ball, DL; Campbell, WB; Egan, BM; Goodfriend, TL; Nithipatikom, K, 2004)
"Obesity is an important risk factor for surgical site infections."( Eagon, C; Fleshman, JW; Kabon, B; Kurz, A; Nagele, A; Reddy, D; Sessler, DI, 2004)
"Overweight and obesity are strongly associated with an elevated risk of stone formation in both genders due to an increased urinary excretion of promoters but not inhibitors of calcium oxalate stone formation."( Glatz, S; Hesse, A; Nicolay, C; Siener, R, 2004)
"Obesity is a complex trait that is affected by both environmental and genetic risk factors."( Chen, C; Chen, D; Hao, K; Hong, X; Huang, A; Huo, Y; Liu, J; Niu, T; Peng, S; Ronnenberg, A; Wang, B; Wang, Y; Wu, D; Xing, H; Xu, X; Yu, Y; Zhang, X; Zhao, X; Zhu, G, 2004)
"Obesity is a common problem in much of the western world today in that is linked directly with several disease processes, notably, hypertension."( Aneja, A; El-Atat, F; McFarlane, SI; Sowers, JR, 2004)
"Obesity is associated with increased cardiovascular morbidity and mortality, in part through development of hypertension."( Haynes, WG; Rahmouni, K, 2004)
"Obesity is a chronic medical disorder that is not going away anytime soon."( Hill, JO; Wyatt, HR, 2004)
"Obesity is associated with increased inactivation of cortisol by hepatic A-ring 5alpha- and 5beta-reductases, impaired hepatic regeneration of cortisol from cortisone by 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1), but increased subcutaneous adipose 11HSD1 activity enhancing local cortisol levels in fat."( Andrew, R; Elia, M; Faber, P; Gibney, ER; Johnstone, AM; Lobley, G; Stubbs, RJ; Walker, BR, 2004)
"Obesity is an important risk factor for asthma."( Fredberg, JJ; Johnston, RA; Rivera-Sanchez, YM; Schwartzman, IN; Shore, SA; Silverman, ES; Valone, J, 2004)
"Obesity is an increasing public health problem."( Craanen, ME; Mijnhout, GS; Smulders, YM, 2004)
"Since obesity is a chronic disorder, a long-term approach is essential, and modern obesity pharmacotherapy means medicating as an adjunct to diet and physical activity not only to achieve weight loss, but also to maintain it."( Ryan, DH, 2004)
"Obesity is associated with the development of leptin resistance."( Bhatt, BA; Dedousis, N; Huang, W; O'Doherty, RM, 2004)
"Diet-induced obesity is associated with an increase of hypothalamic mu opioid receptors."( Barnes, MJ; Dunbar, JC; Jen, KL, 2004)
"Although obesity is associated with increased cardiovascular risk, the mechanism has not been fully explained."( D'Agostino, RB; Levy, D; Lipinska, I; Massaro, J; Mittleman, MA; Muller, JE; Rosito, GA; Sutherland, P; Tofler, GH; Wilson, PW, 2004)
"Obesity is a major epidemic, but its causes are still unclear."( Bray, GA; Nielsen, SJ; Popkin, BM, 2004)
"Visceral obesity is closely associated with cardiovascular disease and the metabolic syndrome."( Ahn, CW; Cha, BS; Choi, SH; Huh, KB; Hur, KY; Kim, HJ; Kim, KR; Kim, SK; Lee, HC; Lim, SK, 2004)
"Abdominal obesity is associated with increased incidence of metabolic disorders and insulin resistance."( Giusti, V; Martin-Du Pan, RC, 2004)
"Obesity is associated with hypertension, but is not known to be associated with SVCs."( Simon, G, 2004)
"Obesity is characterized by whole-body insulin resistance, yet the expression of many insulin-stimulated genes, including leptin, is elevated in obesity."( Funabashi, T; Kleopoulos, SP; Mizuno, TM; Mobbs, CV, 2004)
"Obesity is a major risk factor for the development of heart failure, but the precise mechanisms remain uncertain."( Frohlich, ED; Harris, BC; Mehra, MR; Park, MH; Scott, RL; Uber, PA; Ventura, HO, 2004)
"Obesity is a risk factor for impaired cardiac performance, particularly in women."( Dence, C; Gropler, RJ; Herrero, P; Kisrieva-Ware, Z; Klein, S; Marsala, J; Meyer, T; Peterson, LR; Racette, SB; Schechtman, KB; Waggoner, AD, 2004)
"In young women, obesity is a significant predictor of increased MVO2 and decreased efficiency, and insulin resistance is a robust predictor of MFAUp, MFAU, and MFAO."( Dence, C; Gropler, RJ; Herrero, P; Kisrieva-Ware, Z; Klein, S; Marsala, J; Meyer, T; Peterson, LR; Racette, SB; Schechtman, KB; Waggoner, AD, 2004)
"Obesity is a risk factor for cardiovascular diseases, in particular for hypertension."( Correia, ML; Haynes, WG, 2004)
"Upper body obesity is characterized by an expansion of the visceral adipose tissue and is associated with an increased susceptibility for type 2 diabetes and cardiovascular disease."( Hauner, H; Röhrig, K; Van Harmelen, V, 2004)
"Obesity is also accompanied by an enhanced basal inflammatory tone, originating from adipocytes and adipose tissue-associated macrophages."( Nawrocki, AR; Scherer, PE, 2004)
"Obesity is a major public health problem, which occurs in epidemic proportions."( Rosmond, R, 2004)
"The prevalence of obesity is increasing in the United States and in other westernized societies."( Harp, JB, 2004)
"Although obesity is associated with increased inflammation, it is unclear whether this accounts for the increased cardiovascular risk in obesity."( Engström, G; Hedblad, B; Janzon, L; Jonsson, S; Lind, P; Lindgärde, F; Stavenow, L, 2004)
"Obesity is a worldwide pandemic that causes a multitude of co-morbid conditions."( Barinas-Mitchell, E; Cottam, DR; Eid, G; Kelley, DE; Kuller, L; Mattar, SG; Schauer, PR, 2004)
"Obesity is a global public health problem, with about 315 million people worldwide estimated to fall into the WHO-defined obesity categories."( Bagchi, D; Bagchi, M; Khanna, S; Phillips, C; Rink, C; Roy, S; Sen, CK, 2004)
"Obesity is a risk factor for cardiovascular diseases."( Correia, ML; Haynes, WG, 2004)
"Central obesity is associated with disturbances of hypothalamic-pituitary-adrenocortical (HPA) axis function."( Brydon, L; Kunz-Ebrecht, SR; Steptoe, A; Wardle, J, 2004)
"Obesity is a risk factor for arthritis, but the relationship between arthritis and weight has not been well characterized at the population level in the United States."( Bolen, J; Mehrotra, C; Naimi, TS; Pearson, K; Serdula, M, 2004)
"Obesity is the one of the fundamental problems in societies of the highly developed countries."( Kawecka-Jaszcz, K; Rajzer, M; Wojciechowska, W, 2004)
"Obesity is characterized by sympathetic activation and predisposes to hypertension, but may be associated with low or normal adrenal medullary activity."( Eide, I; Fossum, E; Høieggen, A; Kjeldsen, SE; Moan, A; Reims, HM, 2004)
"The epidemic of obesity is worldwide."( Bray, GA, 2004)
"The treatment of obesity is strongly recommended because many studies have shown it to be a strong risk factor for cardiovascular disease."( Birden, F; Sabuncu, T; Ucar, E; Yasar, O, 2004)
"Obesity is associated with increased hepatic glycogen content."( Ackermans, MT; Allick, G; Bisschop, PH; Endert, E; Meijer, AJ; Romijn, JA; Sauerwein, HP; Sprangers, F; Weverling, GJ, 2004)
"Obesity is among the most pressing health issues affecting developed countries."( Gold, MS; James, GA; Liu, Y, 2004)
"Obesity is associated with lower skeletal muscle capillarization and lower insulin sensitivity."( Gavin, TP; Hickner, RC; Moore, RA; Pofahl, WE; Ryan, NA; Stallings, HW; Westerkamp, LM; Zwetsloot, KA, 2005)
"Obesity is associated with diabetes and gallstone formation."( Graewin, SJ; Kiely, JM; Lee, KH; Nakeeb, A; Pitt, HA; Svatek, CL, 2004)
"Obesity is a major risk factor for the development of cardiovascular disease."( Chen, AF; Chen, MS; Lin, SB; Luo, JD; Wang, YZ; Xu, FP; Yi, Q, 2004)
"Pediatric obesity is an emerging problem in developing countries, especially among higher socio-economic status groups."( Chhatwal, J; Riar, SK; Verma, M, 2004)
"Upper body obesity is associated with insulin resistance, hypertension, and endothelial dysfunction."( Halliwill, JR; Jensen, MD; Joyner, MJ; Nielsen, S, 2004)
"Obesity is associated with a higher MESOR (rhythm-adjusted mean; P < 0."( Cornélissen, G; Gaudiano, P; Halberg, F; Mancuso, F; Mello, G; Perfetto, F; Tarquini, R; Tempestini, A, 2004)
"Obesity is a common and serious metabolic disorder in the developed world that is occasionally accompanied by type II diabetes, atherosclerosis, hypertension, and hyperlipidemia."( Ezaki, O; Kamei, Y; Takahashi, M, 2005)
"Obesity is the main cause of premature death in the UK."( Bloom, SR; Small, CJ, 2004)
"Obesity is a chronic disease with a worldwide increasing incidence."( Ludvik, B; Tripp, B, 2004)
"When obesity is present, both serum AGII and serum leptin were strong predictor of BP, which is not the case in lean females in whom only serum AGII is a predictor of BP."( Al-Hazimi, AM; Syiamic, AY, 2004)
"Obesity is a well-known risk factor of atherosclerosis."( Coskun, S; Jale, C; Sarac, M; Serdar, A; Serdar, Z; Yesilbursa, D, 2005)
"Childhood obesity is associated with lower plasma levels of lipophilic antioxidants which may contribute to a deficient protection of low-density lipoproteins (LDL)."( Andler, W; de Sousa, G; Menke, T; Niklowitz, P; Reinehr, T, 2004)
"Obesity is a clinical syndrome caused by genetic and environmental factors and has a relatively high heretability."( Wu, HL; Zhang, CB, 2004)
"Obesity is constantly increasing among children."( Campanaro, P; Chiarelli, F; D'Angelo, G; Di Ferdinando, C; Di Pietro, M; Pomilio, M; Verrotti, A, 2004)
"Obesity is considered important factor contributing development of PCOS."( Banaś, M; Jochemczyk-Banek, U; Olszanecka-Glinianowicz, M; Zahorska-Markiewicz, B; Zurakowski, A, 2004)
"Because obesity is one of the most important risk factors for cardiovascular diseases and type 2 diabetes, obese children, who are presumably at a higher risk, may be protected from these diseases by the phenotypic effect of the Ala 12 allele on insulin resistance."( Alemanno, I; Buzzetti, R; Caiazzo, AM; Capizzi, M; di Mario, U; Mein, CA; Osborn, JA; Petrone, A; Vania, A; Zavarella, S, 2005)
"Obesity is quickly becoming one of the most common and debilitating disorders of the developed world."( Cowley, MA; Enriori, PJ; Jobst, EE, 2004)
"Obesity is associated with an increased risk for type 2 diabetes mellitus, dyslipidemia, hypertension, biliary disease, obstructive sleep apnea, and certain types of cancer."( Joyal, SV, 2004)
"Obesity is the current major cause of premature death in the UK, killing almost 1000 people a week."( Bloom, SR; Small, CJ, 2004)
"Because overweight/obesity are defined as an excess of adipose tissue mass, all approaches in prevention and treatment must consider redirecting lipid storage in adipose tissue to oxidative metabolism."( Calsbeek, DJ; Eckel, RH; Morris, AM, 2004)
"Furthermore, obesity is a well characterized insulin resistant condition that is often associated with hepatic steatosis."( Muggeo, M; Venturi, C; Zamboni, C; Zoppini, G, 2004)
"Human obesity is associated with leptin resistance and cholesterol gallstone formation."( Goldblatt, MI; Graewin, SJ; Lee, KH; Nakeeb, A; Pitt, HA; Svatek, CL; Tran, KQ, 2004)
"Diet-induced obesity is the primary determinant of the current epidemic of diabetes."( Almind, K; Kahn, CR, 2004)
"Obesity is strongly associated with hypertension and cardiovascular disease."( Correia, ML; Haynes, WG; Mark, AL; Rahmouni, K, 2005)
"Obesity is a growing health concern in Canada and the United States, and pharmacologic therapies such as orlistat are being more commonly prescribed to assist with weight loss."( Fergusson, D; Hutton, B, 2004)
"Obesity is frequently associated with eating disorders, and evidence indicates that both conditions are influenced by genetic factors."( Bouchard, C; Bouchard, L; Chagnon, Y; Drapeau, V; Lemieux, S; Pérusse, L; Provencher, V; Rao, DC; Rice, T; Tremblay, A; Vohl, MC, 2004)
"Abdominal obesity is associated with blunted GH secretion and a cluster of cardiovascular risk factors that characterize the metabolic syndrome."( Andersson, B; Bengtsson, BA; Brandberg, J; Franco, C; Johannsson, G; Lönn, L, 2005)
"Obesity is a principal causative factor in the development of metabolic syndrome."( Fujita, T; Furukawa, S; Iwaki, M; Makishima, M; Matsuda, M; Nakajima, Y; Nakayama, O; Shimabukuro, M; Shimomura, I; Yamada, Y, 2004)
"Obesity is the result of an imbalance between energy intake and expenditure; hence, an understanding of how gastrointestinal function is integrated with the hormonal regulation of energy balance is pertinent to the pathophysiology of obesity."( Ahima, RS; Scharf, MT, 2004)
"Obesity is an increasingly prevalent problem with many associated health risks."( Ghali, P; Lindor, KD, 2004)
"Obesity is a risk factor for high blood pressure (HBP)."( Alvarez-Aguilar, C; Amato, D; Gómez-García, A; Mondragón-Jiménez, LI; Paniagua-Sierra, R; Ramírez-Enríquez, J, 2004)
"Obesity is suggested as a risk factor for asthma, but the mechanisms are unclear."( Böttcher, MF; Leijon, I; Mai, XM, 2004)
"Adolescent obesity is becoming a health problem in both developed and developing countries."( Appolinario, JC; Carraro, L; Coutinho, W; Godoy-Matos, A; Guedes, EP; Mattos, L; Moreira, RO; Oliveira, J; Rangel, C; Vieira, A, 2005)
"Obesity is a global epidemic effecting the health and life style of millions of people in both developed and developing countries."( Altuntas, I; Basaran, N; Basaran, P; Tamer, MN, 2004)
"Obesity is a risk factor for postmenopausal breast cancer and is associated with shortened latency and/or increased mammary tumor (MT) incidence in animals."( Cleary, MP; Grande, JP; Juneja, SC; Maihle, NJ, 2004)
"Obesity is a chronic disease with a marked impact on health and the prevalence of obesity in Croatia is rapidly rising."( Majanović, SK; Ruzić, A; Stimac, D, 2004)
"Obesity is a common consequence in patients with tumors of the hypothalamic region and of related treatment in children."( Daousi, C; Dunn, AJ; Foy, PM; MacFarlane, IA; Pinkney, JH, 2005)
"Obesity is highly prevalent in adult survivors of hypothalamic tumors."( Daousi, C; Dunn, AJ; Foy, PM; MacFarlane, IA; Pinkney, JH, 2005)
"Obesity is considered a chronic disease requiring treatment."( Dakovska, G; Dakovska, L; Kirilov, G; Koev, D; Lazarova, M; Tankova, T, 2004)
"Overweight and obesity are frequently associated with increased plasma levels of aldosterone suggesting a direct link between obesity hypertension and increased mineralocorticoid levels."( Arakelyan, K; Bornstein, SR; Ehrhart-Bornstein, M; Krug, AW; Scherbaum, WA, 2004)
"Obesity is a major risk factor for Syndrome X and type II diabetes (T2D)."( Chen, X; Kim, JK; Li, J; Li, Y; Liu, F; Liu, X, 2005)
"Obesity is closely related to type 2 diabetes and long-term weight reduction is an important part of the care delivered to obese persons with diabetes."( Avenell, A; Gregg, E; Lau, J; Norris, SL; Schmid, CH; Zhang, X, 2005)
"Obesity is the most common health problem in developed countries."( Feigenbaum, A; Pasternak, S; Sarid, M; Vinker, S; Zusk, E, 2005)
"Maternal obesity is likely a risk factor for neural tube defects (NTDs)."( Cole, DE; Meier, C; Ray, JG; Vermeulen, MJ; Wyatt, PR, 2005)
"Because obesity is a major risk factor for cardiovascular disease, we examined whether diet-induced obesity alters the BP and HR responses to stress and whether these alterations are associated with augmented cardiovascular morbidity in the rat."( Bérubé, J; Dumont, M; Gaudet, D; Hamet, P; Pausová, Z; Sedová, L; Tremblay, J, 2004)
"Obesity is a growing worldwide epidemic that is associated with serious medical complications."( Astrup, A; Toubro, S, 2004)
"Obesity is common in persons with schizophrenia."( Berry, S; Brar, JS; Ganguli, R; Mahmoud, R; Pandina, G; Turkoz, I, 2005)
"Obesity is an independent and modifiable risk factor for cardiovascular disease, and known as a core of the metabolic syndrome."( Jeong, SK; Kim, YH; Kweon, SS; Nam, HS; Seo, MW, 2005)
"Currently, obesity is considered a systemic inflammation; however, the effects of obesity on the vulnerability of dopaminergic neurons to oxidative stress are not fully defined."( Choi, JY; Jang, EH; Kang, JH; Park, CS, 2005)
"Obesity is an ever increasing pathological condition in Western countries."( Conti, AA; Gensini, GF; Lippi, D, 2004)
"Obesity is increasing in severity and prevalence in the United States and represents a major public health issue."( Campos, AC; Coelho, JC; Meguid, MM; Ramos, EJ, 2005)
"Obesity is also an increasing public health concern."( Johnson, EJ, 2005)
"Childhood obesity is prevalent and linked to the development of Type 2 diabetes mellitus (DM) and poor bone health."( Gillam, ME; Mollard, RC; Taylor, CG; Weiler, HA; Wood, TM, 2005)
"Obesity is associated with marked increases in plasma leptin concentration, and hyperleptinemia is an independent risk factor for coronary artery disease."( Dick, GM; Dincer, UD; Focardi, M; Knudson, JD; Koshida, R; Picchi, A; Swafford, AN; Tune, JD; Zhang, C, 2005)
"In conclusion, obesity is an important risk factor for clinical and angiographic restenosis and for composite major adverse cardiac events in patients who receive bare-metal stents."( Ellis, SG; Kimmelstiel, C; Kosinski, E; Leon, MB; McGarry, TF; Mehran, R; Mishkel, GJ; Nikolsky, E; Russell, ME; Stone, GW, 2005)
"The obesity is associated with hyperphagia and decreased activity."( Andrews, M; Davis, RE; Fath, MA; Mullins, RF; Nishimura, DY; Rahmouni, K; Searby, C; Sheffield, VC; Sigmund, CD; Stone, EM; Tayeh, MK; Wei, J; Yang, B, 2005)
"Obesity is common in the liver transplant population, but it seems to be unrelated to any specific immunosuppressive drug."( Gunson, B; Johnson, J; Neuberger, J; Richards, J, 2005)
"Human obesity is associated with abnormal hepatic cholesterol homeostasis and resistance to leptin action."( Cohen, DE; Frank, PG; Hyogo, H; Jelicks, LA; Lisanti, MP; Locker, JD; Roy, S; Silver, DL; Wu, MK; Yadav, SK, 2005)
"Obesity is a major risk factor for the development of hypertension."( Kikuchi, K; Murakami, O; Sone, M; Takahashi, K; Totsune, K, 2005)
"Obesity is closely associated with life-style-related diseases."( Han, LK; Kimura, Y; Okuda, H; Yoshikawa, M; Zheng, YN, 2005)
"Obesity is associated with an increased incidence of diabetes, hypertension, dyslipidaemia and coronary artery disease."( Elisaf, MS; Filippatos, TD; Kiortsis, DN; Liberopoulos, EN; Mikhailidis, DP, 2005)
"Obesity is a major risk factor for insulin resistance, but the association of the Pro(12)Ala polymorphism with body weight has been controversial."( Hällsten, K; Kemppainen, J; Knuuti, J; Laakso, M; Lautamäki, R; Nuutila, P; Peltoniemi, P; Pihlajamäki, J; Takala, T; Vänttinen, M; Viljanen, AP; Virtanen, KA, 2005)
"Most forms of obesity are associated with diminished responsiveness to the appetite-suppressing effects of leptin."( Münzberg, H; Myers, MG, 2005)
"Both asthma and obesity are large and growing public health issues."( Fredberg, JJ; Shore, SA, 2005)
"Obesity is associated with elevated levels of leptin in the blood."( Czekay, RP; Dellas, C; Giandomenico, G; Koschnick, S; Loskutoff, DJ, 2005)
"Obesity is associated with impaired insulin-stimulated glucose disposal in the skeletal muscle, but whether this is an intrinsic or acquired factor is unknown."( Goldfine, ID; Houmard, JA; Kulp, JL; MacDonald, KG; Maddux, BA; Pender, C; Tanner, CJ; Youngren, JF, 2005)
"Obesity is associated with endothelial dysfunction and greater arterial stiffness from as early as the first decade of life, while weight loss is beneficial."( Singhal, A, 2005)
"Adult obesity is associated with the metabolic syndrome; however, the prevalence of the metabolic syndrome among young children has not been reported."( Beebe, C; Braunschweig, CL; Doerfler, B; Gomez, S; Liang, H; Lipton, R; Tomey, K; Wang, Y, 2005)
"Obesity is not necessary to observe insulin resistance in humans since severe insulin resistance also characterizes patients lacking subcutaneous fat such as those with HAART (highly-active antiretroviral therapy) - associated lipodystrophy."( Westerbacka, J; Yki-Järvinen, H, 2005)
"The prevalence of obesity is increasing at an alarming rate and a plethora of complementary therapies are on offer claiming effectiveness for reducing body weight."( Ernst, E; Pittler, MH, 2005)
"The prevalence of obesity is rising worldwide dramatically, affecting up to 50 percent of the population."( Ebenbichler, C; Engl, J; Hanusch-Enserer, U; Patsch, JR; Prager, R, 2005)
"Obesity is the current major cause of premature death in the UK, killing almost 1000 people a week."( Bloom, SR; Small, CJ, 2005)
"Adolescent obesity is a serious public health concern."( Bier, DM; Campioni, M; Haymond, MW; Sunehag, AL; Toffolo, G, 2005)
"Obesity is associated with the frailty syndrome in older women in cross-sectional data."( Blaum, CS; Fried, LP; Michelon, E; Semba, RD; Xue, QL, 2005)
"Since obesity is becoming increasingly prevalent worldwide, much effort is being devoted to understanding its pathogenesis and treatment."( Dobrzyn, A; Ntambi, JM, 2005)
"The fact, that obesity is a prominent feature of hypercortisolism (Cushing's syndrome) has stimulated investigation on the possible existence of the reverse relationship, namely that hypercortisolism is a feature of obesity."( Ferenczi, A; Salehi, M; Zumoff, B, 2005)
"Since obesity is associated with expansion of the capillary bed in regional adipose depots the balance between these factors may favor angiogenesis."( Krsek, M; Murphy, LJ; Silha, JV; Sucharda, P, 2005)
"Obesity is characterized by an expanded adipose tissue mass."( Hauner, H, 2005)
"Obesity is taking on pandemic proportions."( Bloom, SR; le Roux, CW, 2005)
"Obesity is becoming more prevalent in the developed world because of the abundance of food and the decrease of physical activity."( Shankar, SS; Steinberg, HO, 2005)
"Obesity is a common sequel to hypothalamic tumors and their treatment, but the underlying mechanisms are not fully established."( Daousi, C; Dovey, TM; English, PJ; Ghatei, MA; Halford, JC; MacFarlane, IA; Patterson, M; Pinkney, JH; Wilding, JP, 2005)
"Obesity is associated with lower B-type natriuretic peptide (BNP) levels in healthy individuals and patients with chronic congestive heart failure (CHF)."( Anwaruddin, S; Baggish, AL; Cameron, R; Chae, CU; Chen, A; Januzzi, JL; Krauser, DG; Lloyd-Jones, DM; Tung, R, 2005)
"Obesity is frequently reported in patients treated for childhood leukaemia."( Bjarnason, R; Bosaeus, I; Jarfelt, M; Johannsson, G; Lannering, B, 2005)
"Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue."( Cordan, J; Coskun, S; Heper, Y; Kazazoglu, AR; Sarac, M; Serdar, A; Yesilbursa, D, 2005)
"Obesity is a global problem with high risks of cardiovascular diseases, stroke and type 2 diabetes."( Epstein, PN; Han, J; Liu, YQ; Xu, J, 2005)
"Obesity is associated with elevated serum leptin levels."( Augoulea, A; Christodoulakos, G; Creatsas, G; Lambrinoudaki, I; Mastorakos, G, 2005)
"Obesity is the most important modifiable risk factor for type 2 diabetes mellitus and most patients with diabetes are overweight or obese."( Hauner, H, 2004)
"Obesity is characterized by a state of mild inflammation, and the expression and release of inflammation-related adipokines generally rises as adipose tissue expands; a notable exception is adiponectin, with its anti-inflammatory action, the levels of which fall."( Trayhurn, P, 2005)
"Obesity is associated with cardiovascular disease, diabetes and certain forms of cancer."( Bagchi, D; Bagchi, M; Downs, BW; Preuss, HG; Shara, MA; Subbaraju, GV, 2005)
"Although abdominal obesity is not very different from generalized obesity in terms of HPA function, subtle variations in HPA axis activity and reactivity are evidenced in A-BFD premenopausal obese women."( Barat, P; Duclos, M; Gatta, B; Marquez Pereira, P; Roger, P, 2005)
"Obesity is an independent cardiovascular risk factor."( Bertomeu, V; Climent, V; Cortés, R; de Burgos, FG; Martinez-Dolz, L; Payá, R; Portolés, M; Rivera, M; Salvador, A; Sevilla, B; Taléns-Visconti, R; Valero, R, 2005)
"Obesity is associated with insulin resistance of glucose and lipid metabolism."( Chevalier, S; Gougeon, R; Lamarche, M; Marliss, EB; Morais, JA, 2005)
"Obesity is an important public health problem in the United States."( Bini, EJ; Blaser, MJ; Cho, I; François, F; Goldberg, JD; Mathew, JP; Ye, XY, 2005)
"Although obesity is generally associated with resistance to the anorexic and weight-reducing actions of leptin, our work has shown preservation of its sympatho-excitatory and pressor actions."( Haynes, WG, 2005)
"Nevertheless, when obesity is present, no reliable estimation can be obtained by using the CG or MDRD formula."( du Cailar, G; Fesler, P; Mimran, A; Ribstein, J; Verhave, JC, 2005)
"Obesity is an independent predictor of left ventricular mass (LVM) and is associated with disturbances in cardiac structure."( Alla, F; Böhme, P; Bruntz, JF; Dousset, B; Hammadi, M; Quilliot, D; Zannad, F; Ziegler, O, 2005)
"Obesity is a major risk factor for coronary heart disease, and surgical treatment of obese patients as part of a multidisciplinary approach seems to provide faster results than diet therapy."( Barbieri, M; D'Andrea, F; Grella, E; Grella, R; Nicoletti, G; Paolisso, G; Ragno, E; Rizzo, MR, 2005)
"Obesity is a condition associated with the accumulation of excessive body fat resulting from chronic imbalance of energy whereby the intake of energy exceeds expenditure."( Looije, NA; Wasan, KM, 2005)
"Obesity is unlikely to resolve spontaneously."( Steinbeck, K, 2005)
"Obesity is the main risk factor for the development of type 2 diabetes."( Bátkai, S; Böhnke, J; Engeli, S; Feldpausch, M; Gorzelniak, K; Harvey-White, J; Janke, J; Jordan, J; Luft, FC; Pacher, P; Sharma, AM, 2005)
"Obesity is associated with an increased risk for cardiovascular disease."( Chizzolini, C; Dayer, JM; Henrichot, E; Juge-Aubry, CE; Meda, P; Meier, CA; Pache, JC; Pernin, A; Velebit, V, 2005)
"Because obesity is associated with hypertension, it is difficult to determine independent effects of ad libitum feeding and obesity in altering diurnal rhythms."( Carroll, JF; Strange, T; Thaden, JJ; Wright, AM, 2005)
"Age-related obesity is associated with impaired hypothalamic pro-opiomelanocortin (Pomc) gene expression."( Li, G; Scarpace, PJ; Wilsey, JT; Zhang, Y, 2005)
"Obesity is associated with altered glucocorticoid metabolism, which may impact on hypothalamic-pituitary-adrenal axis activity."( Andrew, R; Livingstone, DE; McInnes, KJ; Walker, BR, 2005)
"Obesity is a multi-gene syndrome, expression of which is modulated not only by environmental factors but above all by a number of modified genes interacting with each other."( Kempa, A; Krzyzanowska-Swiniarska, B; Robaczyk, M, 2005)
"Obesity is a risk factor for many diseases."( Chiriva-Internati, M; Frezza, EE; Wachtel, MS, 2006)
"Obesity is a risk factor for cardiovascular disease and is strongly associated with insulin resistance and type 2 diabetes."( Abel, ED; Boudina, S; O'Neill, BT; Sena, S; Tathireddy, P; Young, ME, 2005)
"Obesity is a metabolic disorder resulting from imbalance between metabolizable energy intake and energy expenditure."( Haramizu, S; Murase, T; Shimotoyodome, A; Tokimitsu, I, 2006)
"Overweight and obesity are well-established risk factors for cardiovascular disease and decline in kidney function in individuals with existing chronic kidney disease (CKD)."( Buring, JE; Gaziano, JM; Gelber, RP; Kausz, AT; Kurth, T; Levey, AS; Manson, JE, 2005)
"Obesity is associated with a diverse set of metabolic disorders, and has reproductive consequences that are complex and not well understood."( Armstrong, DT; Mitchell, M; Norman, RJ; Robker, RL, 2005)
"Obesity is associated with hypertension and other cardiovascular diseases especially in the African-American population."( Jain, S; Kumar, A; Li, Y; Patil, S, 2006)
"Obesity is strongly associated with arterial hypertension."( Bornstein, SR; Ehrhart-Bornstein, M; Lamounier-Zepter, V, 2005)
"Overweight and obesity are overrepresented in adolescents with type 1 diabetes mellitus (T1DM)."( Connors, MH; Cummings, DE; Glaser, N; Graham, J; Griffen, SC; Havel, PJ; Oostema, K; Stanhope, KL; Styne, DM, 2006)
"Obesity is an independent risk factor for the development of cardiovascular disease frequently associated with hypertension, dyslipemia, diabetes, and insulin resistance."( Cañete, R; Gavilan, MI; Martos, R; Morales, R; Sánchez-Margalet, V; Valle, M, 2006)
"Obesity is associated with altered patterns of substrate utilization at rest and during exercise."( Harber, V; Wong, T, 2006)
"Obesity is associated with increased bile stasis and cholesterol saturation, and an increased risk of gallstone development."( Ullmann, DO; Weinsier, RL, 1993)
"Obesity is associated with low-grade inflammation, insulin resistance, type 2 diabetes, and cardiovascular disease."( Bruun, JM; Helge, JW; Richelsen, B; Stallknecht, B, 2006)
"Although obesity is strongly associated with cardiovascular disease (CVD), the endogenous relationship between obesity and CVD is still not fully clear."( Chen, MS; Luo, JD; Zhang, GS, 2005)
"Obesity is becoming increasingly common worldwide and is strongly associated with the metabolic syndrome (MetS)."( Elisaf, MS; Filippatos, TD; Georgoula, M; Kiortsis, DN; Liberopoulos, EN; Mikhailidis, DP, 2005)
"Obesity is a complex multifactorial chronic disorder recently classified by the American Heart Association (AHA) as a modifiable risk factor for coronary artery disease (CAD)."( Ozdemir, R; Sezgin, AT; Sezgin, N; Topal, E; Yesilada, E; Yologlu, S, 2005)
"Uncorrected obesity is often accompanied by ventricular contractile dysfunction, elevation of the lipotoxic mediator ceramide and the obesity gene product leptin."( Relling, DP; Ren, J, 2006)
"Obesity is recognized as a cofactor in hepatitis C (HCV) liver injury."( Hickman, IJ; Macdonald, GA; Prins, JB; Richards, AA; Wang, AY; Whitehead, JP, 2005)
"Although obesity is strongly associated with cardiovascular disease (CVD), the endogenous relationship between obesity and CVD is still not fully clear."( Chen, MS; Luo, JD; Zhang, GS, 2005)
"Obesity is strongly associated with conditions such as hypertension, diabetes mellitus and osteoarthritis that have known adverse health outcomes."( Cheskin, LJ; Sidhaye, A, 2006)
"Obesity is a major health problem facing the developed and developing world."( Allison, DB; Cutter, G; Fontaine, KR; Haaz, S; Limdi, N; Perumean-Chaney, S, 2006)
"The development of obesity is caused by a disturbance of energy balance, with energy intake exceeding energy expenditure."( Katsilambros, N; Liatis, S; Tentolouris, N, 2004)
"Obesity is the most important risk factor to develop this disease and metformin is considered as a first line drug in overweighted diabetic patients."( Costa Zamora, P; Díaz, JM; González Alvaro, A; Martín Muñoz, MC; Muros Bayo, JM, 2005)
"Obesity is associated with Type II diabetes and hyperlipidemia in murine models."( Al-Azzawi, HH; Goldblatt, MI; Nakeeb, A; Pitt, HA; Swartz-Basile, DA; Tran, KQ, 2006)
"Obesity is associated with dyslipidemia, which leads to elevated triglyceride and ceramide levels, apoptosis and compromised cardiac function."( Carlson, EC; Esberg, LB; Fang, CX; Johnson, WT; Murphy, EJ; Relling, DP; Ren, J; Saari, JT, 2006)
"Peripubertal obesity is associated with marked hyperandrogenemia, which is especially pronounced in early puberty."( Chang, RJ; Chhabra, S; Eagleson, CA; Foster, CM; Marshall, JC; McCartney, CR; Prendergast, KA; Yoo, R, 2006)
"Overweight and obesity are recognised as significant risk factors for coronary heart disease (CHD)."( Gadde, KM, 2005)
"Obesity is associated with an increase in the fractional contribution of gluconeogenesis (GNG) to glucose production."( Burgess, SC; Chevalier, S; Gougeon, R; Malloy, CR; Marliss, EB; Morais, JA, 2006)
"(1) Dietary-induced obesity is accompanied by impaired natriuretic effect of ANP, (2) ANP resistance in obesity may be accounted for by increased leptin level, (3) accelerated degradation of cGMP may contribute to ANP resistance associated with obesity and hyperleptinemia, suggesting that inhibiting cGMP-specific phosphodiesterases may be useful in the treatment of obesity-associated hypertension."( Beltowski, J; Borkowska, E; Jamroz-Wisniewska, A; Marciniak, A, 2006)
"Obesity is a major health problem."( Hagymási, K; Tulassay, Z, 2006)
"Obesity is associated with increased common carotid IMT in young and middle-aged women."( Connelly, JM; Dolan, SE; Grinspoon, SK; Hemphill, LC; Kanter, JR; Lees, RS; Lo, J, 2006)
"Because human obesity is a syndrome of leptin resistance, which is not amenable to leptin treatment, the identification of parallel signal transduction pathways is of potential therapeutic value."( Barouch, LA; Bedja, D; Berkowitz, DE; Gabrielson, KL; Hare, JM; O'donnell, CP; Phan, AC; Raju, SV; Saraiva, RM; Schuleri, KH; Vandegaer, K; Yiginer, O; Zheng, M, 2006)
"In both species obesity is one of the major risk factors for the development of type 2 diabetes."( Boretti, S; Kley, S; Reusch, CE; Sieber-Ruckstuhl, N; Tschour, F, 2006)
"Abdominal obesity is a recognized risk factor for both type 2 diabetes mellitus and cardiovascular disease."( Sharma, AM, 2006)
"Type 2 diabetes and obesity are common metabolic disorders characterized by resistance to the actions of insulin to stimulate skeletal muscle glucose disposal."( Goodyear, LJ; Musi, N, 2006)
"Obesity is less prominent in the congenic TG narcoleptic mice, but is still evident in females."( Fujiki, N; Nishino, S; Sakurai, T; Yanagisawa, M; Yoshida, Y; Zhang, S, 2006)
"Asthma and obesity are prevalent disorders, each with a significant public health impact, and a large and growing body of literature suggests an association between the two."( Beuther, DA; Sutherland, ER; Weiss, ST, 2006)
"The obesity is associated with impaired autocatalytic activation of mature PC1 and reduced hypothalamic alpha-MSH."( Bohan, S; Gekakis, N; Lloyd, DJ, 2006)
"Patients with obesity are susceptible to hypertension."( Fujita, K; Funahashi, T; Hibuse, T; Hiuge, A; Kihara, S; Kumada, M; Maeda, K; Maeda, N; Nishizawa, H; Ohashi, K; Ouchi, N; Ryo, M; Shibata, R; Shimomura, I; Walsh, K, 2006)
"Obesity is a major, growing health problem."( Anderson, M; Chapman, L; Dixon, JB; Laurie, C; Marks, S; McNeil, J; O'Brien, PE; Proietto, J; Schachter, L; Skinner, S; Strauss, B, 2006)
"Childhood obesity is presently increasing worldwide and has created enormous concern for researchers working in the field of obesity related diseases with special interest in child health and development."( Bandyopadhyay, A; Chatterjee, P; Chatterjee, S, 2006)
"Obesity is usually associated with resistance to the effects of leptin on food intake and body weight."( Alquier, T; Asakura, K; Furukawa, N; Kahn, BB; Martin, TL; Preitner, F, 2006)
"Obesity is the major risk factor for the development of hypertension."( de Abreu, VG; Francischetti, EA; Sanjuliani, AF, 2006)
"Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation."( Ferns, GA; Ghayour-Mobarhan, M; Lamb, DJ; Taylor, A, 2007)
"Obesity is frequently accompanied by insulin resistance, type II diabetes, hypertension and atherosclerosis, a cluster of pathologies that are the major components of the metabolic syndrome."( Dobrian, AD, 2006)
"Obesity is associated with low-grade chronic inflammation, and serum markers of inflammation are independent risk factors for cardiovascular disease (CVD)."( Fried, SK; Goldberg, AP; Goldberg, NH; Gong, DW; Horenstein, RB; Hu, H; Hull, K; Lee, MJ; Nicklas, BJ; Pollin, TI; Ryan, AS; Shuldiner, AR; Snitker, S; Yang, RZ, 2006)
"Obesity is associated with endothelial dysfunction that may contribute to the development of diabetes, hypertension, and atherosclerosis."( Goto, K; Iemitsu, M; Jesmin, S; Maeda, S; Matsuo, T; Miyauchi, T; Nakata, Y; Ohkawara, K; Otsuki, T; Tanaka, K, 2006)
"Paediatric obesity is a public health concern worldwide as it can track into adulthood and increase the risk of adult morbidity and mortality."( Ang, M; Khor, GL; Mirnalini, K; Norimah, AK; Zalilah, MS, 2006)
"Obesity is associated with significant increase in cardiovascular risk."( Behn, A; Ur, E, 2006)
"Childhood obesity is characterized by reduced GH secretion."( Anhalt, H; Smotkin-Tangorra, M; Ten, S, 2006)
"Obesity is associated with functional decline in persons with PAD."( Clark, E; Criqui, MH; Ferrucci, L; Greenland, P; Guralnik, JM; Liu, K; McDermott, MM; Pearce, WH; Schneider, JR; Tan, J; Tian, L, 2006)
"Since android obesity is associated with the highest levels of free estradiol, women with this phenotype might not be trivial candidates for EPT."( Christiansen, C; Tankó, LB, 2006)
"Obesity is a risk factor for glucose intolerance, steatosis, and oxidative stress, characteristics of nonalcoholic fatty liver disease."( Cheskin, LJ; Contoreggi, C; Davis, LM; McCullough, K; Moran, TH; Pei, Z; Trush, MA; Watkins, PA, 2006)
"Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents."( Cameron-Smith, D; Chen, MB; Dixon, JB; Kemp, BE; McAinch, AJ; O'Brien, PE; Steinberg, GR, 2006)
"Although obesity is a known risk factor for coronary artery disease, its impact on the presentation, treatment, and outcome of patients with acute coronary syndromes (ACS) has not been well studied."( Boden, WE; Diercks, DB; Gibler, WB; Kirk, JD; Mulgund, J; Ohman, EM; Peterson, ED; Pollack, CV; Roe, MT; Smith, SC, 2006)
"Obesity is a multivariate syndrome which can negatively affect whole body functioning."( Bieńko, M; Filip, RS; Haratym-Maj, A; Panasiuk, L; Puzio, I; Radzki, R, 2006)
"Obesity is a complex multifactorial disease that is often associated with cardiac arrhythmias."( Bonvallet, R; Chouabe, C; Mertani, HC; Morel, G; Raccurt, M; Ricci, E; Smallwood, S, 2006)
"Obesity is a major public health concern and environmental factors are involved in its development."( Halpern, A; Mancini, MC, 2006)
"Obesity is associated with increased morbidity and mortality in critically ill patients."( Granger, DN; Russell, J; Scott, LK; Vachharajani, V; Vital, S, 2006)
"Obesity is strongly associated with female infertility, but the mechanisms underlying this relationship are largely unknown."( Chua, SC; McMinn, JE; Tortoriello, DV, 2007)
"Obesity is a metabolic disorder often associated with type 2 diabetes, insulin resistance, and hepatic steatosis."( Benhamed, F; Dentin, R; Dyck, JR; Fauveau, V; Foufelle, F; Girard, J; Hainault, I; Postic, C, 2006)
"Overweight and obesity are important determinants of health leading to adverse metabolic changes, including increase in blood pressure."( Bharambe, MS; Deshmukh, PR; Dongre, AR; Garg, BS; Gupta, SS; Kaur, S; Maliye, C, 2006)
"Obesity is a major heath problem associated with increased cardiovascular mortality."( Bax, JJ; Biagini, E; Elhendy, A; Poldermans, D; Schinkel, AF; Valkema, R; van Domburg, RT, 2006)
"Obesity is an abnormal expansion of the adipose organ and is a pathophysiological response to an imbalance between energy intake and energy expenditure."( Marks, V, 2006)
"Obesity is a chronic disease requiring a similar long term approach to management as that of other chronic conditions."( Dixon, JB, 2006)
"Obesity is associated with lower rates of skeletal muscle fatty acid oxidation (FAO), which is linked to insulin resistance."( Basilio, JL; Berggren, JR; Cortright, RN; Dohm, GL; Hickner, RC; Houmard, JA; Hulver, MW; Sandhoff, KM, 2006)
"Obesity is a major health problem in cats and a risk factor for diabetes."( Ferguson, DC; Hoenig, M; Thomaseth, K; Waldron, M, 2007)
"Early growth and obesity are associated with adult chronic disease."( Hertzman, C; Li, L; Power, C, 2006)
"Diabetes and obesity are two important modifiable risk factors for stroke."( Govindarajan, G; Kurukulasuriya, LR; Sowers, J, 2006)
"Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked."( Brito Díaz, B; Cabrera de León, A; Maeso Fortuny, MC, 2006)
"In mares, obesity is associated with continuous reproductive activity during the non-breeding season."( Fitzgerald, BP; Kennedy, EL; Murphy, BA; Reedy, SE; Sessions, DR; Vick, MM, 2006)
"Obesity is a risk factor for being diagnosed with asthma, but there is conflicting evidence on whether obesity is a risk factor for lung function abnormalities characteristic of asthma."( Allayee, H; Cohen, RI; Dixon, AE; Holbrook, JT; Irvin, CG; Lima, JJ; Shade, DM; Skloot, GS; Smith, LJ; Wise, RA, 2006)
"Obesity is typically associated with increased tumor susceptibility, whereas caloric restriction, a regimen resulting in leanness, inhibits carcinogenesis."( Ablamunits, V; Brazee, IB; Cohen, Y; Gaetz, HP; Klebanov, S; Vinson, C, 2006)
"Obesity is associated with multiple endocrine alterations and changes in the concentration of circulating hormones."( Dumon, HJ; Martin, LJ; Nguyen, PG; Siliart, B, 2006)
"Obesity is characterized by a low-grade inflammatory state, which could play a role in insulin resistance."( Berlan, M; Hejnova, J; Klimcakova, E; Langin, D; Majercik, M; Moro, C; Polak, J; Stich, V; Viguerie, N, 2006)
"Obesity is a very important risk factor for cardiovascular disease, type 2 diabetes mellitus, hypertension, osteoarthritis, fatty liver, metabolic syndrome and respiratory problems."( Amini, M; Aminorroaya, A; Dastjerdi, MS; Kazemi, F; Mohammady, M; Najafian, A, 2007)
"Human obesity is characterized by high levels of leptin, and it has been suggested that obese patients may be leptin resistant."( de la Fuente, RA; de Luis Roman, D; Izaola, O; Sagrado, MG; Vicente, RC, 2006)
"Obesity is associated with chronic low-grade inflammation."( Bracale, R; Cantoni, O; Cardile, A; Carruba, MO; Clementi, E; Cozzi, V; Moncada, S; Nisoli, E; Palomba, L; Pisconti, A; Tedesco, L; Valerio, A, 2006)
"The prevalence of obesity is increasing rapidly and the associated morbidity and mortality has led to an urgent need for potential therapeutic targets to reduce appetite and food intake."( Bloom, SR; Druce, MR, 2006)
"Visceral obesity is an important determinant of low-grade inflammation in metabolic syndrome."( Bogdański, P; Chyrek, R; Jabłecka, A; Pupek-Musialik, D, 2006)
"Obesity is an important risk factor in endometrial cancer."( Chudecka-Głaz, A; Cymbaluk, A; Rzepka-Górska, I, 2008)
"Obesity is independently associated with increased cardiovascular risk."( Chade, AR; Galili, O; Lerman, A; Lerman, LO; Mannheim, D; McConnell, JP; Olson, ML; Sattler, KJ; Versari, D, 2007)
"Obesity is a known risk factor diabetes, lipid disorders and hypertension."( Chizyński, K; Rózycka, M, 2006)
"Abdominal obesity is the main determinant of uric acid variance."( Albayrak, S; Hergenç, G; Karabulut, A; Keleş, I; Onat, A; Sari, I; Uyarel, H; Yazici, M, 2006)
"Obesity is a growing public health problem."( Fu, Y; Katsuya, T; Kawaguchi, H; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2006)
"Obesity is becoming one of the most serious public health problems in industrialized societies, due to the profound changes in lifestyle, and notably in nutrition."( Delanoye, A; Macia, L; Tailleux, A; Verwaerde, C; Wolowczuk, I, 2006)
"Obesity is often accompanied by insulin resistance and/or hyperinsulinemia."( Bellot-Rojas, P; Caracas-Portilla, N; Cardoso-Saldaña, G; Jurado-Santacruz, F; Posadas-Romero, C; Posadas-Sanchez, R; Zamora-Gonzalez, J, 2006)
"Obesity is the second largest cause of preventable death in the United States."( Arcuri, V; Blum, K; Blum, S; Braverman, ER; Chen, TJ; Deutsch, R; Downs, BW; Gordon, CA; Mangucci, JF; Meshkin, B; Pons, MM, 2007)
"The development of obesity is influenced by both genetic and environmental risk factors."( Astrup, A; Blaak, EE; Boutin, P; Clement, K; Dina, C; Froguel, P; Hoffstedt, J; Holst, C; Langin, D; Larsen, LH; Martinez, JA; Pedersen, O; Polak, J; Santos, JL; Saris, WH; Sorensen, TI; Taylor, MA; Toubro, S; Verdich, C, 2006)
"Obesity is a frequent complication following liver transplantation and is insufficiently responsive to dietary and life style advice."( Aerts, R; Cassiman, D; Fevery, J; Libbrecht, L; Mertens, A; Muls, E; Nevens, F; Pirenne, J; Roelants, M; Van der Merwe, SW; Vandenplas, G; Verslype, C, 2006)
"Overweight or obesity are associated with lower postprandial gastric volumes and normal PYY levels."( Baxter, KL; Burton, DD; Camilleri, M; Jensen, MD; Stephens, DA; Vazquez Roque, MI; Zinsmeister, AR, 2006)
"As obesity is an independent determinant of IMCL content, we examined mitochondrial function and IMCL content in overweight type 2 diabetes patients and BMI-matched normoglycaemic controls."( Backes, WH; Hesselink, MK; Jeneson, JA; Kooi, ME; Mensink, M; Schrauwen, P; Schrauwen-Hinderling, VB; van Echteld, CJ; van Engelshoven, JM, 2007)
"Obesity is associated with hyperlipidemia and enlarged intramyocellular triglyceride (imcTG) stores."( Guo, Z; Zhou, L, 2006)
"Obesity is associated with alterations in the autonomic nervous system that may contribute to the increase in blood pressure and resting energy expenditure present in this condition."( Biaggioni, I; Byrne, DW; Chen, KY; Davis, SN; Diedrich, A; Ertl, AC; Farley, G; Gamboa, A; Paranjape, SY; Shibao, C, 2007)
"Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear."( Blank, SK; Caprio, S; Chang, RJ; Chhabra, S; Eagleson, CA; Foster, CM; Helm, KD; Marshall, JC; McCartney, CR; Prendergast, KA; Yoo, R, 2007)
"Peripubertal obesity is associated with hyperandrogenemia and hyperinsulinemia throughout puberty, being especially marked shortly before and during early puberty."( Blank, SK; Caprio, S; Chang, RJ; Chhabra, S; Eagleson, CA; Foster, CM; Helm, KD; Marshall, JC; McCartney, CR; Prendergast, KA; Yoo, R, 2007)
"The rising tide of obesity is one of the most pressing health issues of our time, yet existing medicines to combat the problem are disappointingly limited in number and effectiveness."( Cummings, DE; Foster-Schubert, KE, 2006)
"Obesity is a risk factor for cardiovascular disease, whereas high cardiorespiratory fitness (CRF) is cardioprotective."( Carek, PJ; Diaz, VA; Geesey, ME; Mainous, AG; Player, MS, 2006)
"Obesity is an important contributor to the risk of developing insulin resistance, diabetes, and heart disease."( Folmes, CD; Lopaschuk, GD, 2007)
"Obesity is associated with a blunted beta-adrenoceptor-mediated lipolysis and fat oxidation."( Arner, P; Blaak, EE; Jocken, JW; Saris, WH; Schiffelers, S; van Baak, MA, 2007)
"Obesity is an important determinant of serum TT levels in ageing men."( Allan, CA; Burger, HG; Forbes, EA; McLachlan, RI; Strauss, BJ, 2006)
"Obesity is a major public health problem."( Avery, PJ; Hall, DH; Keavney, B; Rahman, T, 2006)
"Obesity is a low grade inflammatory state associated with premature cardiovascular morbidity and mortality."( McCance, DR; McMahon, R; Powell, L; Ryan, KE; Trimble, ER, 2007)
"Obesity is a very common disease worldwide, resulting from a disturbance in the energy balance."( Katsilambros, N; Liatis, S; Tentolouris, N, 2006)
"Obesity is a growing public health problem in developing countries considering its association with cardiovascular risk factors."( Fakhrzadeh, H; Hamidi, A; Heshmat, R; Larijani, B; Moayyeri, A; Noori, M; Pourebrahim, R; Rezaeikhah, Y, 2006)
"Obesity is associated with persistent platelet activation in otherwise healthy women."( Basili, S; Ciabattoni, G; Davì, G; Guagnano, MT; Manigrasso, MR; Pacini, G; Patrono, C; Pettinella, C; Santilli, F, 2006)
"Although obesity is associated with decreased levels of cortisol, this relationship may be lost in patients with BED."( Appolinario, JC; Coutinho, WF; Moreira, RO; Spagnol, C, 2007)
"Obesity is associated with insulin resistance and inflammation."( Aljada, A; Chaudhuri, A; Dandona, P; Daoud, N; Deopurkar, R; Ghanim, H, 2007)
"Obesity is an important and growing public health issue that is estimated to affect more than half of the UK adult population."( Adam, DJ; Bradbury, AW; Darvall, KA; Sam, RC; Silverman, SH, 2007)
"In the nonpregnant, obesity is associated with dyslipidemia, vascular dysfunction, and low-grade chronic inflammation."( Caslake, M; Ferrell, WR; Freeman, DJ; Greer, IA; Ramsay, JE; Stewart, FM, 2007)
"Obesity is a clinical feature of patients with Cushing's disease."( Bartalena, L; Bogazzi, F; Cosci, C; Costa, A; Locci, T; Manetti, L; Martino, E; Raggi, F; Russo, D; Santini, F; Sardella, C; Ultimieri, F, 2007)
"Obesity is a state of mild inflammation correlated with increased oxidative stress."( Bernlohr, DA; Griffin, TJ; Grimsrud, PA; Picklo, MJ, 2007)
"Obesity is associated with increased levels of leptin."( Barrett, KE; Bertelsen, LS; Dharmasena, D; Hoda, MR; Junger, WG; Keely, SJ, 2007)
"Abdominal obesity is associated with endothelial dysfunction, through direct mechanisms, such as insulin resistance and the association with risk factors (including diabetes mellitus, hypertension and dyslipidemia), and direct, by the production of adipokines and pro-inflammatory cytokines, which in turn induce oxidative stress leading to a reduced nitric oxide availability."( Ghiadoni, L; Salvetti, A; Salvetti, G; Taddei, S; Virdis, A, 2006)
"Obesity is considered as an inflammatory disease, in which free radical-induced oxidative stress and excessive intake of macronutrients exacerbate their symptoms."( Campión, J; Fernández, D; Martínez, JA; Milagro, FI, 2006)
"Obesity is a risk factor for heart failure through a set of hemodynamic and hormonal adaptations, but its contribution at the molecular level is not clearly known."( Desmoulin, F; Dumonteil, N; Galinier, M; Harmancey, R; Hennig, S; Malet-Martino, M; Massabuau, P; Pathak, A; Perez, L; Roncalli, J; Rouet, P; Senard, JM; Smih, F, 2007)
"Obesity is considered a mild inflammatory condition and predisposes individuals to an increased risk of developing many diseases."( Costa, B, 2007)
"Obesity is a risk factor for several inflammation-based diseases including arthritis."( Croci, T; Zarini, E, 2007)
"Childhood obesity is now considered to be an epidemic."( Delemarre-van de Waal, HA; Gerver, WJ; Kester, AD; Saris, WH; Van Mil, EG; Westerterp, KR, 2007)
"As human obesity is characterized by hyperleptinemia and leptin resistance, increasing leptin sensitivity is an attractive target for obesity treatment."( Correia, ML; Haynes, WG, 2007)
"Obesity is associated with increased risk for postmenopausal, but not premenopausal breast cancer."( Fuchs, G; Hakkak, R; Holley, AW; Jo, CH; Kieber-Emmons, T; Korourian, S; MacLeod, S; Shaaf, S; Simpson, P, 2007)
"Obesity is a risk factor for the development and progression of arthritis."( Bartlett, SJ; Fontaine, KR; Haaz, S, 2007)
"Obesity is often complicated by hypertension, and both conditions are risk factors for atherosclerosis."( Ihara, S; Kawana, M; Sakai, R; Shimamoto, K; Watanabe, H, 2006)
"Abdominal obesity is a prevalent, worldwide problem linked to cardiometabolic comorbidities and an increased risk of coronary heart disease."( Duffy, D; Rader, D, 2007)
"Obesity is associated with significant morbidity and mortality and is increasing in prevalence worldwide."( Alam, I; Baxter, JN; Lewis, K; Stephens, JW, 2007)
"Obesity is associated with accelerated atherosclerosis and increased rates of cardiovascular death."( Fantuzzi, G; Mazzone, T, 2007)
"Overweight and obesity are common concerns in individuals with severe mental disorders."( Borgeat, F; Chatton, A; Fresard, E; Grasset, F; Khazaal, Y; Pomini, V; Rabia, S; Rothen, S; Zullino, D, 2007)
"Obesity is a risk factor for gallbladder disease."( Chien, CW; Lee, TS; Lee, WJ; Lee, YC; Liew, PL; Lin, YC; Wang, W, 2007)
"Childhood obesity is an established problem in many countries and emerging in others."( Ibrahim Md, S; Izzuna Mudla, MG; Mohd Rodi, I; Muhammad Amir, K; Nurziyana, I; Sumarni Mohd, G, 2006)
"Abdominal obesity is associated with a decreased plasma concentration of HDL cholesterol and with qualitative modifications of HDL, such as triglyceride enrichment."( Duvillard, L; Gambert, P; Perségol, L; Vergès, B, 2007)
"Obesity is associated with a flattening of the diurnal rhythm; plasma cortisol levels are slightly increased during the trough, although they are normal or low in the morning."( Bergström, SA; Burén, J; Loh, E; Mattsson, C; Olsson, T; Söderström, I, 2007)
"Obesity is an important risk factor for cardiovascular diseases."( Borda, F; Borgulya, G; Braunitzer, F; Faragó, K; Móczár, C; Vörös, V, 2007)
"Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance."( Arner, P; Blaak, EE; Holm, C; Hul, GB; Jocken, JW; Langin, D; Saris, WH; Smit, E; Valle, C, 2007)
"Obesity is present in a significant proportion of children presenting for anesthesia."( Saade, E; Setzer, N, 2007)
"Obesity is a major factor central to the development of insulin resistance and type 2 diabetes."( Cantley, LC; Cho, YR; Choi, CS; Huang, M; Hurov, JB; Kim, HJ; Kim, JK; Lennerz, J; Piwnica-Worms, D; Piwnica-Worms, H; Prior, JL; Shulman, GI; White, LS, 2007)
"Obesity is a major health problem worldwide; it is associated with more than 30 medical conditions and is a leading cause of unnecessary deaths."( Begg, DP; Chen, N; Jois, M; Mathai, ML; Sinclair, AJ; Weisinger, RS, 2007)
"Obesity is associated with low testosterone levels in diabetic men."( Aldred, H; Channer, KS; Clark, S; Jones, TH; Kapoor, D, 2007)
"Obesity is linked to a variety of metabolic disorders, such as insulin resistance and atherosclerosis."( Fukuhara, A; Furukawa, S; Hosogai, N; Komuro, R; Matsuda, M; Miyata, Y; Oshima, K; Segawa, K; Shimomura, I; Tanaka, S; Tochino, Y, 2007)
"Obesity is a common health problem that is rapidly increasing among children."( Dallar, Y; Savas Erdeve, S; Topkaya, BC; Yilmaz, FM; Yilmaz, G; Yücel, D, 2007)
"The prevalence of obesity is rising among children because of their change in lifestyle."( Mathur, KP; Sharma, A; Sharma, K, 2007)
"Obesity is a major modifiable risk factor for cardiovascular disease."( Amore, C; Baccante, G; de Gaetano, G; di Febbo, C; DI Santo, A; Donati, MB; Lorenzet, R; Napoleone, E; Porreca, E, 2007)
"Obesity is a major public health problem in the Western world resulting in serious social, physical and psychological damages."( da Mota, GR; Zanesco, A, 2007)
"Female obesity is linked to abnormal menstrual cycles, infertility, reproductive wastage, and deficient LH, FSH, and progesterone secretion."( Berga, SL; Feng, S; Gibbs, K; Isaac, B; Jain, A; Loucks, T; Polotsky, AJ; Polotsky, HN; Rochester, D; Santoro, N; Zeitlian, G, 2007)
"Obesity is closely linked to the incidence of type II diabetes."( Al-Mousawi, M; Al-Zaid, NS; Asfar, SK; Behbahani, AI; Dashti, HM; Khadada, M; Mathew, TC; Talib, H, 2007)
"Obesity is associated with an impaired immune response, an increased susceptibility to bacterial infection, and a chronic increase in proinflammatory cytokines such as IL-6 and TNFalpha."( Beck, MA; Harp, JB; Sheridan, PA; Smith, AG, 2007)
"The incidence of obesity is increasing in the United States and around the world, and it is likely that obese patients will present for orthodontic therapy in greater numbers in the future."( Gonzales, DA; Neeley, WW, 2007)
"Obesity is associated with increased cardiovascular morbidity and mortality, in part through development of hypertension."( Alvarez, AL; Burgueno, A; Garcia, SI; Landa, MS; Pirola, CJ; Schuman, ML, 2007)
"Obesity is a risk factor for postmenopausal breast cancer and is associated with poor prognosis."( Cleary, MP; Nkhata, KJ; Ray, A, 2007)
"Obesity is associated with lower TT and disturbances of penile hemodynamics."( Ibrahim, Y; Kamal, EE; Zohdy, W, 2007)
"Obesity is responsible for the mounting incidence of metabolic disease in adult and pediatric populations."( Badman, MK; Flier, JS, 2007)
"Obesity is frequently associated with the consumption of high carbohydrate/fat diets leading to hyperinsulinemia."( Escalante, B; Gonzalez-Granillo, M; Hernández-Pando, R; Noriega-López, L; Santillán-Doherty, P; Torres, N; Tovar, AR, 2007)
"Severe obesity is a major problem in patients suffering from craniopharyngioma (CP), a benign tumor located in pituitary and hypothalamic regions."( Gebhardt, U; Hunneman, DH; Müller, HL; Reinehr, T; Roth, CL; Stoffel-Wagner, B, 2007)
"Obesity is associated with insulin resistance and a state of abnormal inflammatory response."( Araújo, EP; Carvalheira, JB; Carvalho-Filho, MA; Curi, R; Hirabara, SM; Prada, PO; Saad, MJ; Schenka, AA; Tsukumo, DM; Vassallo, J; Velloso, LA, 2007)
"Obesity is common in patients undergoing percutaneous coronary intervention (PCI)."( Hursting, MJ; Jang, IK, 2008)
"Obesity is a growing health problem in the United States."( Cederbaum, AI; Dey, A, 2007)
"At the same time obesity is an escalating health problem worldwide."( Adam, TC; Epel, ES, 2007)
"Adolescent obesity is a major public health problem."( Blakesley, V; Crow, S; Cwik, K; Daniels, SR; Harris, L; Hewkin, A; Jasinsky, O; Long, B; Sothern, M; Styne, D; Vargas-Rodriguez, I; Walch, J, 2007)
"Obesity is a risk factor for cardiovascular disease and thromboembolic events."( Horigome, H; Katayama, Y; Matsui, A; Murakami, T; Nakata, Y; Tanaka, K, 2007)
"Obesity is positively associated with hyperinsulinaemia, and it has been suggested that hyperinsulinaemia may contribute to maintain the obese state in insulin-resistant obese individuals."( Astrup, A; Due, A; Eriksen, G; Flint, A; Hansen, JB; Møller, B; Raben, A, 2007)
"Obesity is related to insulin resistance and hypertension, but the underlying mechanisms are unclear."( Eringa, EC; Roos, MH; Sipkema, P; Stehouwer, CD; Westerhof, N, 2007)
"Obesity is a major risk factor for cardiovascular disorders, including peripheral arterial disease."( Giusti, V, 2007)
"Obesity is a major risk factor for atherosclerosis and is associated with increased cardiovascular morbidity and mortality."( Ait-Oufella, H; Barateau, V; Clément, K; Esposito, B; Gourdy, P; Herbin, O; Holvoet, P; Mallat, Z; Merval, R; Taleb, S; Tedgui, A; Verreth, W, 2007)
"Obesity is an emerging risk factor for renal dysfunction, but the mechanisms are poorly understood."( Boesen, EI; Hair, CD; Mintz, JD; Pollock, DM; Stepp, DW; Sullivan, JC, 2007)
"Obesity is a global public health problem."( Bagchi, D; Bagchi, M; Khanna, S; Rink, C; Roy, S; Sen, CK; Shah, H, 2007)
"Obesity is associated with an increased risk of heart failure."( Marwick, TH; Wong, C, 2007)
"The prevalence of obesity is growing at an alarming rate."( Fabricatore, AN; Wadden, TA, 2006)
"Obesity is well known to be a contributory risk factor for several disease states, including diabetes mellitus."( Al-Harmi, J; Al-Rashdan, I; Al-Saleh, E; Al-Shammari, M; Nandakumaran, M, 2007)
"Although obesity is a risk factor for development of type 2 diabetes and chemical modification of proteins by advanced glycoxidation and lipoxidation end products is implicated in the development of diabetic complications, little is known about the chemical modification of proteins in adipocytes or adipose tissue."( Baatz, JE; Baynes, JW; Bethard, J; Blatnik, M; Brock, JW; Frizzell, N; Nagai, R; Thorpe, SR; Walla, MD, 2007)
"Obesity is a serious public health problem throughout the world, affecting both developed societies and developing countries."( Inui, A; Kamiji, MM, 2007)
"Obesity is associated with an increased risk of development of chronic heart failure, but recent epidemiological studies indicate that a higher body mass index (BMI) is associated with a better survival rate."( Kawano, S; Kozai, T; Tanaka, H; Urabe, Y, 2007)
"Overweight and obesity are associated with arterial hypertension."( Bochud, M; Burnier, M; Vogt, B, 2007)
"Obesity is a highly prevalent disease with multiple implications for cardiovascular morbidity and mortality."( Farmer, JA; Mehta, S, 2007)
"Obesity is a major risk factor in the development of chronic renal failure."( Barbosa, I; Bidouard, JP; Cadrouvele, C; Dedio, J; Gouraud, L; Herbert, JM; Janiak, P; Le Fur, G; Maffrand, JP; O'Connor, S; Pierre, F; Poirier, B, 2007)
"Obesity is associated with oxidative stress and inflammation."( Kim, CH; Rodriguez-Iturbe, B; Vaziri, ND, 2007)
"The development of obesity is characterized by an increase in adipose tissue mass and by concomitant and profound changes in almost all organ functions leading to diseases such as hypertension, diabetes mellitus and coronary heart disease."( Boschmann, M; Thielecke, F, 2007)
"Obesity is characterized by hyperinsulinemia, hyperleptinemia, and an increase in islet volume."( Asilmaz, E; Dishinger, JF; Elias, CF; Elmquist, JK; Hu, J; Kennedy, RT; Kulkarni, RN; Kurpad, AJ; Li, H; Morioka, T, 2007)
"Central obesity is associated with type 2 diabetes mellitus, hypertension and dyslipidaemia."( Stimson, RH; Walker, BR, 2007)
"Obesity is associated with infiltration of macrophages into adipose tissue, and macrophages are an important source of nitric oxide (NO)."( Abe, M; Fukuhara, A; Hosogai, N; Komuro, R; Matsuda, M; Nozaki, M; Okuno, Y; Segawa, K; Shimomura, I, 2007)
"The prevalence of obesity is increasing at an alarming rate, but, unfortunately, only a few medications are currently on the market."( Bhutani, KK; Birari, RB, 2007)
"Type 2 diabetes and obesity are major risk factors for the development of cardiovascular atherosclerosis."( Duncan, ER; Kahn, M; Kearney, MT; Wheatcroft, SB, 2008)
"Obesity is a major cause of increased morbidity and mortality among patients with PWS."( Almeida, MQ; Carvalho, DF; Cercato, C; Halpern, A; Mancini, MC, 2007)
"Obesity is an increasingly prevalent health problem, and natural effective therapeutic approaches are required to prevent its occurrence."( Cederroth, CR; Doerge, DR; Foti, M; Kühne, F; Madani, R; Nef, S; Rohner-Jeanrenaud, F; Vassalli, JD; Vinciguerra, M; Visser, TJ, 2007)
"Obesity is a major risk factor for development of thrombotic cardiovascular disease."( Cleuren, AC; Hoylaerts, MF; Lijnen, HR; Nagai, N; Rosendaal, FR; Van Hoef, B; Van Vlijmen, BJ, 2007)
"Obesity is an increasing global epidemic."( Camilleri, M; Grudell, AB, 2007)
"MSG obesity is an early-onset obesity resulting from MSG-induced lesions in arcuate nucleus to neonatal mice."( Kiss, A; Maixnerová, J; Maletínská, L; Matyšková, R; Pirník, Z; Železná, B, 2008)
"Obesity is associated with increased prevalence and incidence of asthma, but the mechanism is unknown."( Berend, N; King, GG; Munoz, PA; Salome, CM; Schachter, LM; Thorpe, CW, 2008)
"Obesity is associated with occlusive artery disease but is not considered a risk factor for abdominal aortic aneurysm (AAA)."( Clancy, P; Golledge, J; Jamrozik, K; Norman, PE, 2007)
"Measures of obesity are independently associated with AAA."( Clancy, P; Golledge, J; Jamrozik, K; Norman, PE, 2007)
"Obesity is associated with impaired treatment responses in chronic hepatitis C."( Brandt, LR; Cua, IH; George, J; Hui, J; Kench, JG; Negro, F; Poustchi, H, 2008)
"In men, obesity is associated with low testosterone levels."( Gambineri, A; Pasquali, R; Patton, L, 2007)
"Obesity is a rapidly increasing, worldwide epidemic."( Lautz, DB; Mogensen, KM; Robinson, MK; Waseem, T, 2007)
"Overweight and obesity is one of the risk factors for developing CVD."( Binns, CW; Dhaliwal, SS; Khossousi, A; Pal, S, 2008)
"Obesity is a major and independent cardiovascular risk factor."( Aguilar Llopis, A; Arístegui Urrestarazu, R; Armada Peláez, B; Cosín Aguilar, J; Hernándiz Martínez, A; Masramón Morell, X; Rodríguez Padial, L; Zamorano Gómez, JL, 2007)
"Obesity is a multifactorial chronic disorder which comprises a serious health problem nowadays."( Elisaf, MS; Florentin, M; Liberopoulos, EN, 2008)
"Obesity is a major public health problem and is often associated with type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome."( Belouzard, S; Chen, P; Corset, L; Couturier, C; Dam, J; Dubart, A; Froguel, P; Jockers, R; Lenain, A; Mallet, J; Rouillé, Y; Sarkis, C; Séron, K; Vauthier, V, 2007)
"The prevalence of obesity is rising dramatically in developed and developing countries."( Mazzone, T, 2007)
"Obesity is usually associated with resistance to the effect of leptin on food intake and energy homeostasis."( Metlakunta, AS; Sahu, A; Sahu, M, 2008)
"Obesity is highly prevalent among patients treated with atypical antipsychotics for schizophrenia."( Akhtar, S; Ameen, S; Manjunatha, N; Saddichha, S, 2007)
"Obesity is characterised by increased triacylglycerol storage in adipose tissue."( Blaak, EE; Frayn, KN; Goossens, GH; Jocken, JW; Pakbiers, MT; Saris, WH; Stegen, J; van Baak, M; van Hees, AM, 2008)
"Obesity is often associated with the development of heart failure, but the precise mechanisms remain uncertain."( Chen, YS; Huang, CY; Kuo, WW; Lee, SD; Lu, MC; Tsai, CH; Tzang, BS; Wu, FL, 2007)
"Obesity is associated with substantial metabolic changes and subclinical inflammation."( Büchele, G; Koenig, W; Kroke, A; Nagel, G; Rapp, K; Wabitsch, M; Weiland, SK; Zöllner, I, 2008)
"--Obesity is an important healthcare issue."( Boekholdt, SM; Jukema, JW; Peters, RJ, 2007)
"Obesity is a risk factor for postmenopausal breast cancer and is associated with shortened mammary tumor (MT) latency in MMTV-TGF-alpha mice with dietary-induced obesity."( Cleary, MP; Dogan, S; Grande, JP; Hu, X; Maihle, NJ; Zhang, Y, 2007)
"OLETF rat obesity is secondary to the hyperphagia and has been proposed to derive from two regulatory deficits."( Moran, TH, 2008)
"Obesity is associated with impaired endothelial-dependent flow-mediated dilation, a precursor to hypertension and atherosclerosis."( Gutterman, DD; Hoffmann, RG; Jurva, JW; Kulinski, JP; Phillips, SA; Pleuss, J; Syed, AQ, 2008)
"Obesity is increasing worldwide."( Barat, P; Duclos, M; Moisan, MP; Mormède, P, 2008)
"Obesity is associated with an increased risk of developing several comorbid diseases, ranging from cardiovascular diseases to cholelithiasis and nonalcoholic fatty liver disease."( Kaila, B; Raman, M, 2008)
"Obesity is a well-known risk factor for the development of insulin resistance, type 2 diabetes, dyslipidemia, hypertension, and cardiovascular disease."( Bulcão, C; Ferreira, SR; Giuffrida, FM; Ribeiro-Filho, FF, 2006)
"Obesity is an independent risk factor for cardiovascular diseases."( Dong, F; Ren, J, 2007)
"Obesity is considered one of the risk factors for metabolic disorders such as diabetes mellitus."( Masaki, T; Yoshimatsu, H, 2007)
"Obesity is an increasing health problem not only in the industrialized western countries but, also in the developing countries like India."( Ashwin, PJ; Dilipbhai, PJ, 2007)
"Obesity is considered one of the risk factors for metabolic disorders."( Masaki, T; Yoshimatsu, H, 2007)
"Obesity is a negative prognostic factor in patients with critical illnesses such as acute pancreatitis (AP)."( Herrington, MK; Segersvärd, R; Tsai, JA; Wang, F, 2008)
"Obesity is associated with several endocrine diseases, including common ones such as hypothyroidism and polycystic ovarian syndrome to rare ones such as Cushing's syndrome, central hypothyroidism and hypothalamic disorders."( Weaver, JU, 2008)
"Obesity is associated with resistance to the effects of leptin."( Hatzinikolas, G; Janovská, A; Mano, M; McInerney, J; Staikopoulos, V; Wittert, GA, 2008)
"Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors."( Cabello, PH; Duarte, SF; Francischetti, EA; Genelhu, VA; Pimentel, MM, 2007)
"Obesity is associated with cognitive impairments."( Abdul, HM; Banks, WA; Butterfield, DA; Farr, SA; Miller, NE; Morley, JE; Xu, L; Yamada, KA, 2008)
"Obesity is associated with the changes of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNFalpha) and transforming growth factor beta (TGFbeta) levels."( Ataç, FB; Kinik, ST; Ozbek, N; Verdi, H; Yazici, AC; Yuce, M, 2008)
"Obesity is an infertility factor in otherwise normal men."( Demers, LM; Dodson, WC; Kunselman, AR; Lee, PA; Legro, RS; Pauli, EM, 2008)
"Obesity is regarded as a risk factor for colorectal cancer."( Esumi, H; Fujii, S; Fujioka, R; Kuga, W; Ochiai, A; Ochiya, T; Ogura, T; Saito, M; Tsuchihara, K, 2008)
"Since obesity is correlated with oxidative stress, and GPX3 has been demonstrated to be lower in obesity and higher after weight loss, we hypothesize that GPX3 is one important mediator of effects of estrogen in relation to fat mass."( Andersson, S; Dahlman-Wright, K; Gustafsson, JA; Lundholm, L; Ohlsson, C; Otsuki, M; Putnik, M, 2008)
"Obesity is characterised by hyperleptinaemia and hypoadiponectinaemia: we have hypothesised that these hormonal factors may contribute to the progression of OAC."( Beales, IL; Ogunwobi, OO, 2008)
"The prevalence of obesity is increasing in dogs as well as in humans."( Barbosa, PR; Campos, R; de Oliveira, ST; Dos Santos, AP; González, FH; Price, CA; Veiga, AP, 2008)
"Obesity is associated with macrophage infiltration of adipose tissue, which may link adipose inflammation to insulin resistance."( Andersson, G; Arner, P; Carneheim, C; Cassady, AI; Hume, DA; Kaaman, M; Lång, P; Parini, P; Rydén, M; van Harmelen, V, 2008)
"Obesity is associated with atherosclerotic risk factors, including reduced blood flow, endothelial dysfunction, lipid disorders and hyperinsulinemia."( Ercan, M; Konukoglu, D, 2008)
"Obesity is a heterogeneous condition, consisting of different phenotypes that are influenced by the regional distribution of adipose tissue."( Bodkin, PA; Ooi, LY; Walker, BR; Whittle, IR, 2008)
"Childhood obesity is a widespread health problem in Australia."( Ashton, J; Bilgin, A; Grant, R; Guy, T; Hokin, B; Pearce, R; Zeuschner, C, 2008)
"Obesity is the main determinant of serum uric acid concentrations in PCOS patients, yet amelioration of androgen excess with an antiandrogenic contraceptive pill results in a significant decrease in these levels, an effect that is not observed with metformin."( Alvarez-Blasco, F; Escobar-Morreale, HF; Luque-Ramírez, M; Uriol Rivera, MG, 2008)
"Obesity is a chronic metabolic disorder that affects one third of American adults."( Aronne, LJ; Neff, LM, 2007)
"Abdominal obesity is associated with metabolic abnormalities and increased risk of atherosclerotic cardiovascular disease."( Bhatt, DL; Cannon, CP; Deanfield, JE; Després, JP; Gaudin, C; Hu, B; Job, B; Kapadia, S; Kastelein, JJ; Lincoff, AM; Nicholls, SJ; Nissen, SE; Rodés-Cabau, J; Ruzyllo, W; Steinhubl, SR; Tuzcu, EM; Wolski, K; Yasin, M, 2008)
"Asthma and obesity are associated disorders, but the contribution of obesity to difficult-to-treat asthma as well as the mechanisms responsible for this relationship are unclear."( Bel, EH; Rabe, KF; Sterk, PJ; Ten Brinke, A; van Veen, IH, 2008)
"Obesity is an important correlate of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels."( D'Agostino, RB; Ellison, RC; Fox, CS; Hwang, SJ; Liang, TJ; Loomba, R; O'Donnell, CJ; Vasan, RS, 2008)
"Obesity is a major risk factor for endometrial cancer, a relationship thought to be largely explained by the prevalence of high estrogen levels in obese women."( Anderson, G; Burk, RD; Einstein, MH; Gunter, MJ; Harris, TG; Ho, GY; Hoover, DR; Howard, BV; Kaplan, RC; Li, J; Manson, JE; Pollak, MN; Rohan, TE; Strickler, HD; Wassertheil-Smoller, S; Wylie-Rosett, J; Xue, X; Yu, H, 2008)
"Obesity is accompanied by impaired fasting glycerol release, lower HSL protein expression, and serine phosphorylation."( Blaak, EE; Goossens, GH; Jocken, JW; Kiens, B; Roepstorff, C; Saris, WH; van Baak, M; van der Baan, P, 2008)
"Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are now recognized to possess significant inflammatory components underlying their pathophysiologies."( Leibel, R; Tortoriello, DV; Weisberg, SP, 2008)
"Obesity is a major risk factor for insulin resistance and type 2 diabetes."( Benelli, C; Cadoudal, T; Forest, C; Fouque, F, 2008)
"Human obesity is associated with increased serum phenylalanine concentration, which is probably caused by liver dysfunction related to liver steatosis."( Sledzinski, T; Sledzinski, Z; Slominska, E; Smolenski, R; Swierczynski, J, 2009)
"Obesity is associated with increased risk of developing stage 3 CKD, which was no longer significant after adjustment for known cardiovascular disease risk factors."( Foster, MC; Fox, CS; Hwang, SJ; Larson, MG; Levy, D; Lichtman, JH; Parikh, NI; Vasan, RS, 2008)
"Obesity is a major cause of premature death in the UK, and may contribute to as many as 30 000 deaths a year in the UK."( le Roux, CW; Vincent, RP, 2008)
"Obesity is a growing worldwide problem and is associated with a wide range of adverse effects on the female reproductive system."( Ledger, WL; Li, TC; Metwally, M, 2008)
"Obesity is not statistically associated with NT-proBNP levels in HT asymptomatic patients."( Bertomeu, V; Calabuig, JR; Cortés, R; de Burgos, FG; Grigorian, L; Lozano, T; Martínez-Dolz, L; Morillas, P; Otero, MR; Portolés, M; Roselló-Lletí, E; Soria, F, 2008)
"Obesity is characterized by systemic low-grade inflammation in which adipose tissue, especially the omental depot, is thought to play a key role."( Froguel, P; Frühbeck, G; Lecoeur, C; Pattou, F; Poulain-Godefroy, O, 2008)
"Obesity is a risk factor for headache "chronification."( Alexander, G; Peterlin, BL; Reichenberger, E; Tabby, D, 2008)
"Obesity is now regarded as a global epidemic affecting both adults and children, and is associated with significant morbidity and mortality."( Crowley, VE, 2008)
"Obesity is a chronic disease that is linked to the presence of numerous chronic illnesses, including venous disease."( Jarrett, M; Tobón, J; Whitney, JD, 2008)
"The presence of obesity is an indispensable factor, with any two or more of the following criteria: (1) a high serum level of triglyceride and/or low serum level of HDL cholesterol; (2) high blood pressure; (3) high fasting plasma glucose concentration."( Amezawa, M; Kawada, T, 2008)
"Obesity is associated with increased severity of acute pancreatitis (AP)."( Cabay, RJ; Dinarello, CA; Fantuzzi, G; Fayad, R; Gove, ME; Pini, M; Ponemone, V; Sennello, JA; Siegmund, B, 2008)
"Obesity is an important risk factor for the development of cardiovascular disease."( Lavie, CJ; Milani, RV; Ventura, HO, 2008)
"Obesity is a disorder of energy balance and is associated with hyper-insulinemia, insulin resistance, and abnormalities in lipid metabolism, and it is one of the most important risk factors in the development of Type II diabetes, cardiovascular disease, atherosclerosis, and certain cancers."( Jensen, L; Ørgaard, A, 2008)
"Obesity is a widespread disease in both the developed and developing world."( De Simone, G; Di Fiore, A; Supuran, CT, 2008)
"Obesity is associated with a decreased risk of breast cancer in premenopausal women but an increased risk in postmenopausal women, an effect that increases with time since menopause."( Lee, S; Pearce, CL; Pike, MC; Spicer, DV; Wu, AH, 2007)
"Obesity is associated with infiltration of macrophages into adipose tissue."( Duval, C; Kersten, S; Keshtkar, S; Müller, M; Stienstra, R; van der Laak, J, 2008)
"Abdominal obesity is closely related to type 2 diabetes and overactivity of the endocannabinoid system."( Paquot, N; Scheen, AJ, 2008)
"Human obesity is characterized by high levels of leptin, and it has been suggested that obese patients may be leptin-resistant."( Aller, R; Conde, R; de Luis, DA; Izaola, O; Sagrado, MG, 2008)
"Obesity is a significant risk factor for psoriasis and body mass index (BMI) correlates with disease severity."( Aphale, A; Arnadottir, S; Elder, JT; Gudjonsson, JE; Gunnarsson, SI; Johnston, A; Sigmarsdottir, AA; Steinsson, JT; Valdimarsson, H, 2008)
"Obesity is very often associated with hypertension, and it has been known that leptin affects the blood pressure by activating the sympathetic nervous system and causing endothelial cell (EC) dysfunction."( Kwan, CY; Leung, YM, 2008)
"Obesity is one of the risk factors in various chronic diseases and malignancy."( Lubis, AR; Setiawati, A; Soegondo, S; Widia, F, 2008)
"Obesity is the most serious long-term health risk currently facing America's adolescents."( Jasik, CB; Lustig, RH, 2008)
"Obesity is the main component of the metabolic syndrome, which appears to be one of the biggest social problems nowadays."( Chrzastek-Spruch, H; Kozłowska, M; Pac-Kozuchowska, E; Zatorska-Karpuś, M, 2008)
"Obesity is a risk factor for acute pancreatitis (AP), but the molecular mechanism remains unclear."( Araki, H; Fukuhara, A; Funahashi, T; Hayashi, N; Kamada, Y; Kataoka, TR; Kihara, S; Kiyohara, T; Matsuda, M; Nishihara, T; Shimomura, I; Tamura, S, 2008)
"Central obesity is linked to elevation in fibrinogen mainly through the mediation of blood pressure, CRP, and via being affected by cigarette smoking."( Albayrak, S; Can, G; Erbilen, E; Hergenç, G; Keleş, I; Küçükdurmaz, Z; Onat, A; Ozhan, H, 2009)
"Obesity is clearly an independent risk factor for increased severity of acute pancreatitis (AP), although the mechanisms underlying this association are unknown."( Gripe, JT; Lu, D; Mathur, A; Pitt, HA; Swartz-Basile, DA; Wade, TE; Walker, JJ; Yancey, K; Zyromski, NJ, 2008)
"Obesity is a current health pandemia."( Coccurello, R; D'Amato, FR; Moles, A, 2009)
"Obesity is increasing across all socioeconomic groups and educational levels and occurs even among individuals with the highest levels of education and expertise in nutrition and related fields."( Cohen, DA, 2008)
"Obesity is associated with hypertension and glomerular hyperfiltration."( Chagnac, A; Erman, A; Gafter, U; Herman, M; Hirsh, J; Rozen-Zvi, B; Zingerman, B, 2008)
"Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment."( González-Pérez, A; Grilo, A; Manzano, L; Martínez-Larrad, MT; Morón, FJ; Ramírez-Lorca, R; Ruiz, A; Sáez, ME; Serrano-Hernando, J; Serrano-Ríos, M, 2008)
"In humans, obesity is closely associated with insulin resistance (IR) and dyslipidaemia."( Gayet, C; Le Bloc'h, J; Leray, V; Magot, T; Nguyen, P; Ouguerram, K; Serisier, S, 2008)
"Although clinical obesity is associated with increases in the morbidity and mortality of sepsis, little is known about the mechanisms that underlie the influence of obesity on sepsis."( Granger, DN; Singer, G; Stokes, KY; Terao, S, 2009)
"In this sense, obesity is a disease of the BBB."( Banks, WA, 2008)
"Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile."( Bátkai, S; Buettner, C; Godlewski, G; Harvey-White, J; Jeong, WI; Kunos, G; Liu, J; Lutz, B; Marsicano, G; Osei-Hyiaman, D; Zhou, L, 2008)
"Dietary obesity is associated with type 2 diabetes and cardiovascular diseases, although the underlying mechanism is unknown."( Dong, YF; Ichijo, H; Kataoka, K; Kim-Mitsuyama, S; Matsuba, S; Ogawa, H; Tokutomi, Y; Yamamoto, E; Yamashita, T, 2008)
"Obesity is an important endocrine disorder in cats and is a risk factor for diabetes similar to humans."( Hoenig, M; Jordan, E; Kley, S; Le, NA; Waldron, M, 2008)
"Dyslipidemia and obesity are endemic in American youth and require urgent action."( Kwiterovich, PO, 2008)
"Obesity is an important factor in the development of asthma."( Jang, AS; Kim, DJ; Kim, YH; Park, CS; Park, HS; Park, JS; Park, SW; Seo, KH; Uh, ST, 2008)
"Obesity is not a risk factor in the development of asthma in patients with AIA."( Jang, AS; Kim, DJ; Kim, YH; Park, CS; Park, HS; Park, JS; Park, SW; Seo, KH; Uh, ST, 2008)
"Obesity is a major risk factor for developing coronary heart disease."( Girotra, S; Mittleman, MA; Mukamal, KJ; Wee, CC; Weinstein, AR, 2008)
"Obesity is characterized by chronic, low-grade, systemic inflammation, which, in turn, has been associated with anemia of chronic disease."( Ausk, KJ; Ioannou, GN, 2008)
"Obesity is becoming one of the most common health problems in the world."( Han, JS; Tian, DR; Wang, F, 2008)
"Obesity is a central feature of the metabolic syndrome and is associated with increased risk for insulin resistance and typeII diabetes."( Abdou, R; Karagiannides, I; Kypreos, KE; Tzortzopoulou, A; Voshol, PJ, 2008)
"Overweight and obesity are important determinants of health leading to adverse metabolic changes and increase the risk of non communicable diseases."( Bharati, DR; Deshmukh, PR; Garg, BS, 2008)
"Visceral obesity is also associated with an excessive depot of triglycerides and other lipid products (e."( Bonora, E; Brangani, C; Pichiri, I, 2008)
"Obesity is reaching epidemic proportions worldwide and it is correlated with various comorbidities, among which the most relevant are diabetes mellitus, arterial hypertension, and cardiovascular diseases."( Pagotto, U; Pasquali, R; Vanuzzo, D; Vicennati, V, 2008)
"Hypertension and obesity are major components of the cardiometabolic syndrome and are both on the rise worldwide, with enormous consequences on global health and the economy."( Kurukulasuriya, LR; Lastra, G; Manrique, C; Sowers, JR; Stas, S, 2008)
"Obesity is associated with increased morbidity and mortality from cardiovascular disease, diabetes mellitus and certain cancers."( Farooqi, IS; O'Rahilly, S, 2008)
"Obesity is considered one of the risk factors for many cancers."( Gao, Y; He, DL; Li, L; Zhang, LL, 2008)
"However, obesity is heterogeneous both in terms of its etiology and its metabolic complications."( Arsenault, BJ; Cartier, A; Côté, M; Després, JP; Lemieux, I, 2008)
"The incidence of obesity is rapidly increasing all over the world in epidemic proportions."( Attig, L; Djiane, J, 2008)
"The incidence of obesity is increasing worldwide, and in the USA approximately 100 million adults are overweight or obese."( Doggrell, SA, 2008)
"Obesity is a risk factor for incident chronic kidney disease (CKD)."( Benjamin, EJ; Fox, CS; Hoffmann, U; Hwang, SJ; Larson, MG; Levy, D; Massaro, JM; O'Donnell, CJ; Sarnak, MJ; Vasan, RS; Young, JA, 2008)
"Obesity is associated with an elevated risk of hypertension and cardiovascular disease."( Brydon, L; O'Donnell, K; Steptoe, A; Wardle, J; Wawrzyniak, AJ; Wright, CE, 2008)
"Once the state of obesity is reached (relative body mass index, rBMI >121%) the longer lasting care becomes more complex and frequently unsuccessful."( Moya, M, 2008)
"Obesity is a growing global health problem frequently intractable to current treatment options."( Bale, TL; Baltuch, GH; Danish, SF; Grady, MS; Grossman, M; Halpern, CH; Jaggi, JL; Stunkard, AJ; Wolf, JA, 2008)
"Obesity is one of the most significant, and potentially most preventable, risk factors for the development of osteoarthritis, and numerous studies have shown a strong association between body mass index and osteoarthritis of the hip, knee, foot and hand."( Griffin, TM; Guilak, F, 2008)
"Abdominal obesity is associated with a hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and impaired androgen balance, although these alterations differ according to sex."( Gambineri, A; Pagotto, U; Pasquali, R; Vicennati, V, 2008)
"Obesity is a major cause of insulin resistance and contributes to the development of type 2 diabetes."( Ando, H; Honda, M; Kaneko, S; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Ota, T; Sakurai, M; Shimizu, A; Takamura, T; Takeshita, Y, 2008)
"Obesity is associated with accelerated atherosclerosis."( Aust, G; Blüher, M; Hauss, J; Kerner, C; Klöting, N; Kovacs, P; Richter, O; Rohm, S; Ruschke, K; Youn, BS, 2009)
"Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues."( Hotamisligil, GS; Yang, L, 2008)
"Obesity is a major risk factor for asthma and it influences airway smooth muscle function and responsiveness."( Kim, JH; Lee, WY; Shim, JY; Shin, JH, 2008)
"Obesity is a well-known problem in children with acute lymphoblastic leukemia (ALL), and it might be the result of an excess in energy intake, reduced energy expenditure, or both."( Jansen, H; Kamps, WA; Postma, A; Stolk, RP, 2009)
"Obesity is a growing public health problem that is already reaching epidemic proportions and is increasingly encompassing young children and adolescents."( Samat, A; Taheri, S; Thomas, GN; Tomlinson, B, 2008)
"Obesity is recognized as a worldwide health problem."( Besnard, P; Gaillard, D; Passilly-Degrace, P, 2008)
"Overweight/obesity is an independent negative predictive factor of steatosis in chronic hepatitis C virus infection."( Fehér, J; Hagymási, K, 2008)
"Obesity is associated with insulin resistance and the resulting hyperinsulinemia has been attributed to an increase of insulin secretion and a reduction of insulin clearance."( Erdmann, J; Mayr, M; Oppel, U; Schusdziarra, V; Sypchenko, O; Wagenpfeil, S, 2009)
"Obesity is considered a risk factor for asthma."( Aydin, S; Canöz, M; Erdenen, F; Müderrisoglu, C; Uzun, H, 2008)
"Obesity is a major health problem in the United States and many other countries because of its high prevalence and causal relationship with serious medical comorbidities."( Fabbrini, E; Klein, S, 2008)
"Overweight and obesity are major factors contributing to the development of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD)."( Aronne, LJ; Davis, SN; Foster, GD; Pagotto, U, 2008)
"Some forms of obesity are associated with low-level systemic inflammation, which is linked to disease."( Dixon, J; Egger, G, 2009)
"Obesity is epidemic in the 21st century and has been shown to be a risk factor for developing severe acute pancreatitis."( Lu, D; Mathur, A; Pitt, HA; Swartz-Basile, DA; Wade, TE; Zyromski, NJ, 2009)
"Obesity is a common and rapidly growing health problem today."( Abrams, GA; Aprahamian, CJ; Chen, M; Clements, RH; Harmon, CM; Yang, YK, 2008)
"Obesity is a resilient and complex chronic disease."( Scarpace, PJ; Zhang, Y, 2009)
"Maternal obesity is an increasing problem in obstetrics associated with adverse pregnancy outcomes and delivery complications."( Heizer, AB; McLea, SA; Myatt, L; Richardson, JL; Roberts, VH; Smith, J, 2009)
"Obesity is associated with an increased risk of breast cancer."( Caldefie-Chézet, F; Perrier, S; Vasson, MP, 2009)
"Obesity is associated with insulin resistance and a mild chronic inflammation in adipose tissues."( Fukuhara, A; Komuro, R; Matsuda, M; Miyata, Y; Shimomura, I; Tanabe, A; Tojo, H, 2009)
"Obesity is also associated with high levels of insulin, a known mitogen."( Anderson, GL; Burk, RD; Gunter, MJ; Harris, TG; Ho, GY; Hoover, DR; Howard, BV; Kaplan, RC; Li, J; Manson, JE; Rohan, TE; Strickler, HD; Wassertheil-Smoller, S; Wylie-Rosett, J; Xue, X; Yu, H, 2009)
"Obesity is currently a major public health problem and one of the potential underlying causes of obesity in a minority of patients is Cushing's syndrome (CS)."( Akgul, EO; Azal, O; Corakci, A; Kebapcilar, L; Kutlu, M; Ozgurtas, T; Sahin, M; Taslipinar, A; Taslipinar, MY; Yazici, M, 2009)
"Obesity is a growing problem."( Bray, GA, 2008)
"Obesity is defined as the excess storage of energy in the form of fat that results from imbalances between energy intake and expenditure."( Schoeller, DA, 2008)
"Obesity is one of the greatest public health challenges of the twenty-first century."( Idelevich, E; Kirch, W; Schindler, C, 2009)
"The prevalence of obesity is gradually increasing in Japan, but in women aged in their 20 s to 50 s it has been disproportionately decreasing."( Chiba, H; Ishii, K; Kishi, R; Kishimoto, N; Okita, K; Saijo, Y; Sakuma, I; Takada, S; Tsutsui, H, 2009)
"Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain poorly understood."( Bishop, JM; Friedman, JE; Grayson, BE; Grove, KL; McCurdy, CE; Smith, MS; Williams, SM, 2009)
"Obesity is considered a worldwide epidemic."( Höcht, C; Mayer, MA; Puyó, A; Taira, CA, 2009)
"Obesity is a known risk factor for type 2 diabetes."( Butler, AE; Butler, PC; Daval, M; Gurlo, T; Matveyenko, AV, 2009)
"Obesity is associated with an increased incidence and severity of asthma, as well as other lung disorders, such as pulmonary hypertension."( Bloch, KD; Kihara, S; Leyton, P; Libby, P; Luster, AD; Medoff, BD; Okamoto, Y; Raher, MJ; Sandall, BP; Weng, M, 2009)
"Obesity is a chronic sub-inflammatory condition which is a risk factor for several cancer diseases, e."( Hauner, H; Rechkemmer, G; Roser, S; Schnäbele, K; Skurk, T, 2009)
"Obesity is associated with increased prevalence of metabolic disorders, such as inflammation, insulin resistance, and dyslipidemia, which can predispose an individual to develop diabetes and cardiovascular disease."( Gutierrez, DA; Hasty, AH; Puglisi, MJ, 2009)
"Obesity is a risk factor for type 2 diabetes in cats."( Burgess, SC; Ferguson, DC; Glushka, J; Hoenig, M; Jin, ES; Jordan, ET; Kley, S; Olson, DE; Prestegard, JH; Waldron, M; Wu, S, 2009)
"Obesity is one of the major risk factors for cardiovascular disease and is often associated with increased oxidative stress and sympathoexcitation."( Ando, K; Fujita, M; Fujita, T; Kawarazaki, H; Matsui, H; Nagae, A, 2009)
"Obesity is associated with increased risk for developing pancreatic cancer, and it is suggested that insulin resistance provides the missing link."( Arkan, MC; Buck, A; Greten, FR; Hrabe de Angelis, M; Khasawneh, J; Klingenspor, M; Klöppel, G; Rozman, J; Saur, D; Schmid, RM; Schulz, MD; Schwaiger, M; Sipos, B; Walch, A, 2009)
"The incidence of obesity is increasing at an alarming rate and this worldwide epidemic represents an ominous predictor of increases in diseases such as type 2 diabetes and metabolic syndrome."( Bouret, SG, 2009)
"Obesity is associated with low-grade inflammation and leukocyte infiltration in white adipose tissue (WAT) and is linked to diabetic complications."( Bour, S; Carpéné, C; Caspar-Bauguil, S; Casteilla, L; Cousin, B; Iffiú-Soltész, Z; Jalkanen, S; Miiluniemi, M; Nibbelink, M; Pénicaud, L; Salmi, M; Stolen, C; Valet, P, 2009)
"Common obesity is a multi-factorial trait, contributed by the "obesogenic" environment of caloric abundance and increasing automation, sedentary lifestyle and an underlying genetic susceptibility."( Lee, YS, 2009)
"Obesity is a risk factor for increased severity of acute pancreatitis."( Lillemoe, KD; Mathur, A; Pitt, HA; Prather, AD; Swartz-Basile, DA; Wade, TE; Wang, S; Zyromski, NJ, 2009)
"Obesity is associated with endothelial dysfunction and increased inflammation."( Bahri Hernández, E; García de Seijo, MI; Pelayo Jordán, T; Ramírez Alvarado, MM, 2009)
"Obesity is a major risk factor for hypertension."( Girerd, X; Hansel, B, 2009)
"Obesity is considered as a major health problem, as its prevalence continuously rises worldwide."( Choussein, S; Daskalopoulou, SS; Frangos, CC; Makri, AA; Petridou, ET, 2009)
"Obesity is frequently associated with other pathologies: cardiovascular, oncologic, systemic (diabetes) or oral."( Godlewski, AE; Nicolas, E; Veyrune, JL, 2008)
"Childhood obesity is increasingly prevalent in the community and is related to adverse cardiovascular outcomes during adulthood."( Abhayaratna, K; Abhayaratna, WP; Budge, MM; Gravenmaker, KJ; O'Reilly, C; Sakuragi, S; Srikusalanukul, W; Telford, RD, 2009)
"Abdominal obesity is associated with numerous metabolic abnormalities, including insulin resistance, impaired glucose tolerance/type-2 diabetes, and atherogenic dyslipidaemia with low high-density lipoprotein (HDL) cholesterol, high triglycerides, and increased small dense low-density lipoprotein (LDL) cholesterol."( Paquot, N; Scheen, AJ, 2009)
"Obesity is characterized by adipose tissue expansion as well as macrophage infiltration of adipose tissue."( Gurley, C; Kern, PA; McGehee, RE; Nolen, GT; Peterson, CA; Phanavanh, B; Rasouli, N; Simpson, P; Starks, T; Varma, V; Yao-Borengasser, A, 2009)
"Central obesity is a relevant risk factor for major cardiovascular events due to the atherosclerotic involvement of coronary, cerebral and lower limb arterial vessels."( Anfossi, G; Russo, I; Trovati, M, 2009)
"Obesity is caused by combination of genetic and environmental factors."( Brown, TR; Chen, JQ; Russo, J, 2009)
"Aging and obesity are characterized by decreased beta-cell sensitivity and defects in the potentiation of nutrient-stimulated insulin secretion by GIP."( Brooks, LM; Kashyap, SR; Kelly, KR; Kirwan, JP; O'Leary, VB; Solomon, TP, 2009)
"Obesity is an independent risk factor in the etiology of various metabolic diseases such as insulin resistance, type 2 diabetes and cardiovascular diseases."( Kang, JH; Kim, CS; Yu, R, 2009)
"Both depression and obesity are disabling disorders associated with loss over appetite control, influenced by genetic and environmental factors and are risk factors for diseases like hypertension, cardiovascular disorders, etc."( Dube, U; Kapoor, M; Kapur, S; Mehra, S; Sharad, S; Sidhu, S, 2009)
"Obesity is the major cause of type 2 diabetes."( Gómez, R; Gómez-Reino, JJ; Gualillo, O; Lago, F, 2009)
"Obesity is an independent risk factor for the development of end-stage renal disease."( Budge, H; Fainberg, HP; Gardner, DS; Harvey, E; Sharkey, D; Symonds, ME; Wilson, V, 2009)
"Obesity is associated with a high risk of developing diabetes and cardiovascular disease."( Fernandes, G; Halade, GV; Rahman, MM, 2010)
"Obesity is a major health crisis, and diabetes is one of its most serious sequelae."( O'Rourke, RW, 2009)
"Overweight and obesity are associated with low grade of inflammation and chronic inflammatory response characterized by abnormal production and activation of some pro-inflammatory signalling pathways."( Boscaro, M; Cipriano, C; Costarelli, L; Emanuelli, M; Faloia, E; Gasparini, N; Giacconi, R; Giuli, C; Lattanzio, F; Maiani, F; Malavolta, M; Marcellini, F; Mauro, B; Mocchegiani, E; Muti, E; Papa, R; Piacenza, F; Pierpaoli, S; Polito, A; Raguzzini, A; Tesei, S; Tirabassi, G, 2010)
"Obesity is thus one of many diseases shown to have a developmental origin."( Heindel, JJ; vom Saal, FS, 2009)
"Although obesity is associated with multiple features of the metabolic syndrome (insulin resistance, leptin resistance, hepatic steatosis, chronic inflammation, etc."( Badeanlou, L; Bielawski, J; Hannun, YA; Roberts, AJ; Samad, F; Yang, G, 2009)
"Obesity is associated with increased risks for development of cardiovascular diseases."( Agouni, A; Andriantsitohaina, R; Desmoulin, F; Heymes, C; Lagrue-Lak-Hal, AH; Martínez, MC; Mostefai, HA; Mulder, P; Rouet, P; Tesse, A, 2009)
"Obesity is an effect of interaction of genetic and environmental factors."( Huszno, B; Kieć-Klimczak, M; Malczewska-Malec, M, 2008)
"Obesity is a potential risk factor for renal disease in non-diabetic subjects."( Ceriello, A; Comaschi, M; Cucinotta, D; De Cosmo, S; Giorda, C; Nicolucci, A; Pellegrini, F; Pomili, B; Rossi, MC; Valentini, U; Vespasiani, G, 2010)
"Obesity is a worldwide epidemic and a significant risk factor for pancreatic diseases including pancreatitis and pancreatic cancer; the mechanisms underlying this association are unknown."( Gowda, GA; Mathur, A; Murphy, C; Pitt, HA; Raftery, D; Swartz-Basile, DA; Wade, TE; Zyromski, NJ, 2009)
"1."( Barg, E; Grabowski, M; Głab, E; Noczyńska, A; Wikiera, B, 2009)
"Obesity is characterized by the increase of leptin in the circulation."( Chen, Y; Krewski, D; Mai, XM, 2009)
"Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer."( Fettes, A; Freichel, C; Gatti-McArthur, S; Hertel, C; Huwyler, J; Mohr, P; Nakagawa, T; Nettekoven, M; Pierson, PD; Plancher, JM; Raab, S; Richter, H; Roche, O; Rodríguez Sarmiento, RM; Schmitt, M; Schuler, F; Takahashi, T; Taylor, S; Ullmer, C; Wiegand, R, 2009)
"Childhood obesity is increasing worldwide."( Ammini, AC; Chathurvedi, D; Diwedi, S; Gupta, N; Joseph, AA; Khadgawat, R; Kulshrestha, B, 2009)
"Childhood obesity is epidemic in developed countries and is accompanied by an increase in the prevalence of type 2 diabetes (T2DM)."( Barbetti, F; Brufani, C; Cappa, M; Ciampalini, P; Fintini, D; Fiori, R; Grossi, A; Tozzi, A, 2010)
"Obesity is currently a worldwide pandemic."( Velloso, LA, 2009)
"Severe obesity is associated with type 2 diabetes mellitus, and both resolve with weight loss after bariatric operations."( Deitel, M, 2009)
"Obesity is associated with chronic inflammation and low adiponectin, an anti-inflammatory adipokine."( Bala, M; Buechler, C; Kopp, A; Lieberer, E; Neumeier, M; Schäffler, A; Sporrer, D; Stögbauer, F; Wanninger, J; Weber, M; Weigert, J, 2009)
"Obesity is associated with impaired functional hyperemic response."( Hester, RL; Xiang, L, 2009)
"To evaluate whether obesity is associated with changes in pro-inflammatory and immunomodulatory cytokines in pregnancy."( Allan, W; Collins, M; Craig, WY; Dammann, O; Davis, JM; Madan, JC; Quinn, R, 2009)
"Obesity is associated with an increased risk of falls and injury."( Madigan, ML; Matrangola, SL, 2009)
"Obesity is currently reaching epidemic levels worldwide and is a major predisposing factor for a variety of life-threatening diseases including diabetes, hypertension and cardiovascular diseases."( Chen, JZ; Huang, XF, 2009)
"Obesity is associated with increased fatty acid uptake in the myocardium, and this may have deleterious effects on cardiac function."( Borra, R; Iozzo, P; Järvisalo, M; Karmi, A; Knuuti, J; Lautamäki, R; Lepomäki, V; Nuutila, P; Pärkkä, JP; Parkkola, R; Raitakari, OT; Rönnemaa, T; Taittonen, M; Viljanen, AP, 2009)
"The incidence of obesity is increasing; this is of major concern, as obesity is associated with cardiovascular disease, stroke, type 2 diabetes, respiratory tract disease, and cancer."( Doggrell, SA, 2009)
"Obesity is a well known strong risk factor for coronary artery disease (CAD)."( Anazawa, T; Furuya, S; Hirayama, A; Iida, K; Kawamata, H; Kumabe, N; Matsumoto, M; Nagao, K; Takahashi, H; Tani, S; Washio, T, 2009)
"Obesity is one of the greatest public health challenges of the 21st century with 1."( Batterham, RL; Karra, E, 2010)
"Severe childhood obesity is associated with oxidative stress."( Boix-García, L; Codoñer-Franch, P; Del Castillo-Villaescusa, C; Maset-Maldonado, J; Simó-Jordá, R; Valls-Bellés, V, 2010)
"Overweight and obesity are the foremost public health problems in the U."( Van Loan, M, 2009)
"Obesity is associated with inflammation."( Boaz, M; Lisy, L; Wainstein, J; Zandman-Goddard, G, 2009)
"Overweight and obesity are associated with cardiovascular disease (CVD)."( Qin, YW; Qiu, JL; Zhang, JL; Zhao, XX; Zheng, X; Zou, DJ, 2009)
"Obesity is a major driver for the widely prevalent metabolic syndrome and type 2 diabetes mellitus (T2DM) in Asian Indians in India and those residing in other countries."( Chadha, D; Chowbey, P; Gulati, S; Gupta, R; Joshi, SR; Makkar, BM; Misra, A; Munjal, YP; Sadikot, S; Vikram, NK; Wasir, JS, 2009)
"Obesity is associated with resistance to IGF-I at a whole-body level and in the endothelium."( Abbas, A; Ajjan, R; Cubbon, RM; Duncan, ER; Ezzat, VA; Gage, M; Grant, PJ; Imrie, H; Kahn, M; Kearney, MT; Rajwani, A; Viswambharan, H; Wheatcroft, SB, 2009)
"Obesity is a condition of heterogeneous etiology that is harmful for most individuals."( Marcus, MD; Wildes, JE, 2009)
"Obesity is a risk factor for several common diseases, particularity type 2 diabetes mellitus, cardiovascular diseases, and tumors."( Chang, CJ; Chang, TL; Fan, K; Huang, YW; Lee, WY; Lin, MN, 2009)
"Obesity is associated with endothelial dysfunction and inflammation."( Fagan, K; Frye, M; McMurtry, I; Orton, EC, 2009)
"Obesity is an independent risk factor for pancreatic cancer development and progression, although the mechanisms underlying this association are completely unknown."( Mathur, A; Nakshatri, H; Nakshatri, P; Pitt, HA; Swartz-Basile, DA; Wade, TE; Wang, S; Zyromski, NJ, 2009)
"Diabetes and obesity are metabolic disorders induced by an excessive dietary intake of fat, usually related to inflammation and oxidative stress."( Bindels, LB; Cani, PD; de Backer, FC; Delzenne, NM; Menke, T; Neyrinck, AM; Niklowitz, P; Pachikian, BD; Sohet, FM, 2009)
"Maternal obesity is present in 20-34% of pregnant women and has been associated with both intrauterine growth restriction and large-for-gestational age fetuses."( Ballesteros, B; Choi, J; Comuzzie, AG; Cox, L; Dick, EJ; Dudley, DJ; Farley, D; Frost, P; Higgins, PB; Hubbard, GB; Jenkins, SL; Li, C; Nathanielsz, PW; Schlabritz-Loutsevitch, NE; Tejero, ME; Werner, SL; Wu, G, 2009)
"Obesity is an established risk factor for urinary incontinence, yet no information exists as to the efficacy of antimuscarinic agents in this population."( Chancellor, MB; Oefelein, MG; Vasavada, S, 2010)
"Obesity is associated with a more severe OAB disease state."( Chancellor, MB; Oefelein, MG; Vasavada, S, 2010)
"Type 2 diabetes and obesity are characterized by elevated nocturnal circulating free fatty acids, elevated basal insulin secretion, and blunted glucose-stimulated insulin secretion (GSIS)."( Corkey, BE; Deeney, JT; Getty-Kaushik, L; Krawczyk, S; Richard, AM; Shirihai, O, 2009)
"Overweight and obesity are frequently associated with preventable death and have emerged as a major challenge to public health."( Böhm, M; Bramlage, P; Khan, BV; Kirch, W; Reil, JC; Thoenes, M; Volpe, M, 2009)
"Obesity is associated with numerous inflammatory conditions including atherosclerosis, autoimmune disease and cancer."( Chan, Y; Dosch, HM; Engleman, E; Paltser, G; Tsui, H; Winer, D; Winer, S, 2009)
"Obesity is a chronic condition with complex, multiple causes involving physiologic, genetic, and behavioral components, all of which must be addressed for successful treatment."( Fernstrom, MH, 2001)
"Obesity is a significant health problem in the United States today and is associated with increased risk of cardiovascular disease, diabetes, and other chronic conditions."( Hansen, BC, 2001)
"Development of obesity is influenced by both genetic, biochemical and environmental factors."( Bukhari, SA; Nagra, SA; Rajoka, MI; Rehman, ZU, 2010)
"Obesity is an important risk factor for the development of type 2 diabetes, but not all obese individuals develop this complication."( Costford, SR; Crawford, SA; Dent, R; Harper, ME; McPherson, R, 2009)
"Obesity is a major health problem in the developed and developing world."( Boon, N, 2008)
"Childhood obesity is emerging as a major public health threat, with adverse implications on the health of individuals and long-term costs to society."( Uli, NK; Wald, AB, 2009)
"Obesity is a strong risk factor for breast cancer in postmenopausal women and adverse prognostic indicator regardless of menopausal status."( Cleveland, RJ; Eng, SM; Gammon, MD; Gaudet, MM; Long, CM; Neugut, AI; Santella, RM; Teitelbaum, SL, 2010)
"Obesity is epidemic among adolescents in the United States."( , 2010)
"Obesity is characterized by increased storage of fatty acids in an expanded adipose tissue mass and is closely associated with the development of insulin resistance in peripheral tissues such as skeletal muscle and the liver."( Galic, S; Oakhill, JS; Steinberg, GR, 2010)
"Type 2 diabetes and obesity are associated with an enhanced release of a number of adipocytokines."( Bajzova, M; Hejnova, J; Hnevkovska, Z; Klimcakova, E; Kovacikova, M; Kovacova, Z; Langin, D; Polak, J; Rossmeislova, L; Siklova-Vitkova, M; Stich, V; Vrzalova, J, 2009)
"Obesity is thought to increase the risk of asthma, especially in women."( Hancox, RJ; McLachlan, CR; Poulton, R; Sears, MR; Sutherland, TJ, 2009)
"Obesity is a known clinical factor influencing venous blood flow from the lower limbs."( Kózka, M; Krzyściak, W; Pietrzycka, A; Stepniewski, M, 2009)
"Human obesity is associated with increased heat production; however, subcutaneous adipose tissue provides an insulating layer that impedes heat loss."( Brady, SM; Eden, HS; Gorbach, AM; Reynolds, JC; Savastano, DM; Yanovski, JA, 2009)
"Obesity is frequently associated with pain of various origins (e."( Bardin, C; Basdevant, A; Bergmann, JF; Clement, K; Declèves, X; Lepine, JP; Lloret Linares, C; Mouly, S; Oppert, JM; Scherrmann, JM, 2009)
"Obesity is associated with chronic low-grade inflammation but also with a heightened acute inflammatory response."( Fantuzzi, G; Pini, M, 2010)
"Obesity is a multifactorial, chronic disorder that has reached epidemic proportions in most industrialised countries and is threatening to become a global epidemic."( Pavlik, V; Slanska, I; Slovacek, L; Slovackova, B, 2009)
"However, obesity is also associated with hyperlipidaemia and the effects of free fatty acids (FFAs) and triglycerides (TG) on circulating adiponectin levels have not yet been investigated."( Bobbert, T; Mai, K; Möhlig, M; Pfeiffer, AF; Spranger, J; Weicht, J, 2009)
"Obesity is an increasing socio-economic health problem."( Behrendt, P; Bode, FJ; Brabant, G; Buchenauer, T; Horn, R; Nave, H; Stephan, M, 2009)
"Obesity is associated with a high prevalence of erectile dysfunction; however, the pathophysiological link between obesity and erectile dysfunction remains poorly understood."( Feeley, RJ; Guay, A; Traish, AM, 2009)
"Hypertension and obesity are highly prevalent among African Americans (AAs)."( Grim, CE; Kidambi, S; Kotchen, JM; Kotchen, TA; Krishnaswami, S, 2009)
"Obesity is a multi-faceted disease, predisposing sufferers to numerous co-morbidities such as epithelial dysfunction and insulin resistance which ultimately result in CVD."( Pretorius, E; van der Spuy, WJ, 2009)
"Age-related obesity is known to be adjoined by leptin resistance."( Balasko, M; Jech-Mihalffy, A; Petervari, E; Soos, S; Szekely, M, 2010)
"Obesity is associated with lipid abnormalities leading to an increased morbidity and mortality from atherosclerotic disease."( Aigner, F; Ebenbichler, CF; Engl, J; Kaser, S; Laimer, MW; Patsch, JR; Rauchenzauner, M; Ritsch, A; Tatarczyk, T; Tschoner, A; Weiss, H, 2009)
"Obesity is epidemic; new medications and therapeutic options are urgently needed to reduce the associated health care burden."( Niswender, KD; Robinson, JR, 2009)
"Obesity is a risk factor for cardiovascular dysfunction, yet the underlying factors driving this impaired function remain poorly understood."( Ali, MI; Belin de Chantemele, EJ; Black, SM; Fulton, DJ; Ketsawatsomkron, P; Marrero, MB; Mintz, JD; Muta, K; Salet, C; Stepp, DW; Tremblay, ML, 2009)
"Obesity is also a risk factor for gallstones."( Gaby, AR, 2009)
"Obesity is an independent risk factor for development and progression of chronic kidney disease (CKD)."( Beddhu, S; Moustarah, F; Navaneethan, SD; Schauer, PR; Schreiber, MJ; Yehnert, H, 2009)
"Obesity is a risk factor for type 2 diabetes mellitus."( El-Razek, SM; Hashem, RM; Motawi, TM; Rashed, LA, 2009)
"The ID of obesity is predominantly a condition of a true body iron deficit rather than maldistribution of iron due to inflammation."( Braunschweig, C; Fantuzzi, G; Freels, S; Guzman, G; Holterman, AX; Nemeth, E; Tussing-Humphreys, LM, 2010)
"Obesity is one of the most important health problems today."( Beckers, S; Van Gaal, LF; Van Hul, W; Zegers, D, 2009)
"Obesity is a heritable trait that contributes to hypertension and subsequent cardiorenal disease risk; thus, the investigation of genetic variation that predisposes individuals to obesity is an important goal."( Chiron, S; Fung, MM; Hamilton, BA; Khandrika, S; Mahata, M; Mahata, SK; Nievergelt, C; O'Connor, DT; Rao, F; Shih, PA; Wang, L; Wen, G, 2009)
"Maternal obesity is associated with increased rates of labor induction, dysfunctional labor requiring intrapartum cesarean delivery, and postpartum hemorrhage, implying that maternal obesity has an inhibitory effect on myometrial function and its ability to respond to oxytocin."( Anderson, L; Blanks, AM; Higgins, CA; Martin, W; McConnachie, A; Nelson, SM; Norman, JE, 2010)
"Obesity is characterized by neuronal, metabolic and hormonal alterations."( Becskei, C; Lutz, TA; Riediger, T, 2009)
"Overweight and obesity are rapidly expanding health problems in children and adolescents."( Ager, JW; Alliston, T; Barth, HD; Do, SH; Ionova-Martin, SS; Porter, AE; Ritchie, RO; Szadkowska, M; Vaisse, C, 2010)
"Because obesity is associated with chronically elevated leptin, we examined if long-term hyperleptinemia impairs acute effects of leptin on sodium excretion and NO production in the absence of obesity."( Bełtowski, J; Jamroz-Wiśniewska, A; Wójcicka, G; Wojtak, A, 2010)
"The prevalence of obesity is rising dramatically, impacting adversely on health and well-being at the menopause and across the lifespan."( Deeks, AA; Lombard, C; Teede, HJ, 2010)
"Obesity is widely recognized as cause of metabolic syndrome and cardiovascular disease."( Alarcon-Aguilar, FJ; Almanza-Perez, JC; Blancas-Flores, G; Campos-Sepulveda, AE; Cruz, M; Garcia-Macedo, R; Roman-Ramos, R, 2010)
"Obesity is often associated with dyslipidemia, insulin resistance, and hypertension."( Hasty, AH; Morrow, JD; Saraswathi, V, 2009)
"However, obesity is also associated with an increased risk of metabolic syndrome, type 2 diabetes, cancer and other diseases."( Gnacińska, M; Małgorzewicz, S; Stojek, M; Sworczak, K; Łysiak-Szydłowska, W, 2009)
"Obesity is associated with increased insulin resistance and is a well-recognized factor for the development of type 2 diabetes."( Sesti, G, 2009)
"Obesity is nowadays a major public health problem."( Campión, J; Martínez, JA; Milagro, FI; Quintero, P, 2010)
"Childhood obesity is a predisposing factor for adult cardiovascular diseases."( Bajnok, L; Gönczi, F; Harangi, M; Illyés, I; Józsa, L; Koncsos, P; Paragh, G; Seres, I, 2010)
"Obesity is widely believed to be associated with difficult peripheral intravenous access (PIV) placement."( Burke, C; Cowan, A; Maclean, S; Nafiu, OO; Tremper, KK; Tutuo, N, 2010)
"Obesity is associated with increased systemic and airway oxidative stress, which may result from a combination of adipokine imbalance, comorbidities, and reduced antioxidant defenses."( Fitzpatrick, A; Holguin, F, 2010)
"Childhood obesity is a serious health concern affecting over 155 million children in developed countries worldwide."( Clarson, CL; Cramp, AG; Jung, ME; Lenhardt, L; Prapavessis, H; Robinson, T; Shoemaker, JK; Vascotto, J; Watson, M; Wilson, AJ, 2009)
"Obesity is a universal health problem of increasing prevalence and represents a major public health concern."( Arora, R; Bedi, US; Khosla, S; Singh, M; Singh, PP, 2010)
"Obesity is a rapidly-growing public health problem that is related in part to the foods available in the eating environment."( Rolls, BJ, 2010)
"Obesity is a multifactorial disorder influenced by genetic, behavioral, environmental and cultural factors."( Asar, G; Can, S; Darcan, S; Goksen, D, 2010)
"Obesity is associated with increased risk of conditions such as hypertension, dyslipidaemia, diabetes mellitus, and obstructive sleep apnoea."( Cheung, BM; Li, M, 2009)
"As obesity is associated with cardiovascular diseases, the purpose of this study was to investigate the effect of obesity on forearm skin blood flow (FSBF) response to acetylcholine (Ach), an endothelium-dependent vasodilator, in Tunisian women over a wide range of body mass indices (BMIs)."( Abderrazek, E; Ben-Jebria, A; Chouchane, A; Debbabi, H; Miâdi-Messaoud, H; Tabka, Z; Zaouali-Ajina, M, 2010)
"Obesity is frequently associated with insulin resistance and increased inflammation and oxidative stress."( Benhabilès, N; Crombé, F; Geeraert, B; Geuns, JM; Holvoet, P; Hulsmans, M, 2010)
"Obesity is a multifactorial disease that is rarely associated to single gene defects."( Santos M, JL, 2009)
"Obesity is an important health problem because it is associated with diseases such as type 2 diabetes, hypertension, and hyperlipidemia in metabolic syndrome."( Masaki, T; Yoshimatsu, H, 2009)
"Obesity is associated with development of adipose tissue inflammation."( Shwarts, V, 2009)
"A majority of human obesity is inherited as a polygenic trait."( Levin, BE, 2010)
"Obesity is a risk factor for poor outcomes after trauma, and circulating levels of ghrelin are decreased in obese patients."( Cureton, E; Curran, B; Dozier, K; Kwan, RO; Sadjadi, J; Victorino, GP, 2010)
"Obesity is currently considered to be a world epidemic and one of the major public health problems in many countries, whose incidence is increasing at alarming rates."( Biancalana, A; Gomes, L; Veloso, LA, 2010)
"Iron depletion in obesity is thought to be mediated by an inflammation-induced increase in the body's main regulator of iron homeostasis, hepcidin."( Ayloo, S; Braunschweig, C; Fantuzzi, G; Freels, S; Galvani, C; Holterman, AX; Nemeth, E; Tussing-Humphreys, LM; Vitello, J, 2010)
"Obesity is associated with deterioration in asthma outcomes."( Antunes, E; Calixto, MC; Lintomen, L; Saad, MJ; Schenka, A; Zanesco, A, 2010)
"Obesity is a growing global epidemic."( Chan, JC; Guldan, GS; Kong, AP; Lee, HM; Ma, RC; Mong, JL; Ng, MC; So, WY; Tam, CH; Waye, MM; Wong, GW, 2010)
"Obesity is a major risk factor for both BE and EA."( Beresford, SA; Bronner, MP; Kirk, EA; Thompson, OM; Vaughan, TL, 2010)
"Childhood obesity is a global epidemic and associated with an increased risk of hypertension, diabetes mellitus, and coronary heart disease, in addition to psychological disorders."( Reinehr, T; Roth, CL, 2010)
"Obesity is well characterized as a systemic inflammatory condition, and is also associated with cognitive disruption, suggesting a link between the two."( Bilbo, SD; Tsang, V, 2010)
"Obesity is a well-established risk factor for the development and mortality from several cancers, including adenocarcinoma of the oesophagus, oesophago-gastric junction and colorectum."( Howard, JM; Pidgeon, GP; Reynolds, JV, 2010)
"Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease."( Bucala, R; Kleemann, R, 2010)
"Also, obesity is a pro-inflammatory state."( Devaraj, S; Jialal, I; Yun, JM, 2010)
"Obesity is associated with increased cardiovascular disease (CVD) risk, especially when excess body fat is distributed preferentially within the abdominal region."( Filippatos, TD; Joshi, J; Mikhailidis, DP; Seifalian, AM, 2010)
"Overweight and obesity are related with impared ovarian response, and negatively affect the outcomes of IVF."( Ding, G; Gao, H; Huang, H; Lu, X; Qu, F; Wang, T; Zhang, D; Zhang, R; Zhou, B; Zhu, Y, 2010)
"As obesity is a state of low-grade inflammation, we aimed to investigate the combined effect of high-fat diet and bacterial infection on beta-cell function and insulin sensitivity in dogs."( Andonova, M; Dimitrova, S; Dzhelebov, P; Georgiev, IP; Kanelov, I; Mircheva Georgieva, T; Slavov, E, 2010)
"Obesity is frequently associated with modifications of thyroid size and function."( Carta, D; Casini, MR; Civolani, P; Loche, S; Marras, V; Pilia, S; Porcu, M; Uccheddu, AP, 2010)
"Obesity is a risk factor for colorectal cancer and adenomatous polyps."( Burke, CA, 2010)
"Obesity is associated with an increased risk of colon cancer."( Foster, NR; O'Connell, MJ; Rankin, C; Sargent, DJ; Sinicrope, FA, 2010)
"Obesity is an independent prognostic variable in colon cancer survivors and shows gender-related differences."( Foster, NR; O'Connell, MJ; Rankin, C; Sargent, DJ; Sinicrope, FA, 2010)
"Obesity is an important factor in hormone dynamics independent of age, race, and smoking in midlife women, although the mechanisms remain unclear."( Freeman, EW; Gracia, CR; Lin, H; Sammel, MD, 2010)
"Obesity is considered to be an important risk factor for postmenopausal breast cancer."( Cleary, MP; Ray, A, 2010)
"Obesity is typically a consequence of overconsumption driven by an individual's natural sensitivity to food stimuli and the pleasure derived from eating."( Blundell, JE; Boyland, EJ; Halford, JC; Harrold, JA; Kirkham, TC, 2010)
"Obesity is a major cause of insulin resistance and type 2 diabetes."( Zhao, WG; Zhu, HJ, 2010)
"Obesity is a chronic disease and a serious health problem that leads to increased prevalence of diabetes, hypertension, dyslipidemia and gallbladder disease."( Carvalheiro, M; Chambel, P; Correia, LG; da Silva, PM; de Castro, JJ; Dias, T; Guerreiro, L; Marques, O; Medina, JL; Nobre, E; Nunes, JS; Pereiraa, MC; Polónia, J; Portugal, J; Raimundo, A; Reis, JL; Ruas, A; Teles, AG; Vasconcelos, C, 2009)
"As obesity is related to hyperleptinemia, leptin resistance and metabolic syndrome, we aimed to investigate body composition, plasma hormone levels, glucose tolerance and the leptin signaling pathway in hypothalamus from early overfed animals at weaning and adulthood."( Bonono, IT; da Conceição, EP; de Moura, EG; Lisboa, PC; Neto, JF; Passos, MC; Rodrigues, AL; Trevenzoli, IH, 2011)
"Obesity is a risk factor for the development of insulin resistance, which can eventually lead to type-2 diabetes."( Holcomb, VB; Hong, J; Nunez, NP; Paulson, QX, 2010)
"Though obesity is common, some people remain resistant to weight gain even in an obesogenic environment."( Akil, H; Barbosa, MT; Britton, SL; Burghardt, PR; Chini, EN; Escande, C; Koch, LG; Levine, JA; Novak, CM; Zhang, M, 2010)
"Obesity is an escalating global health problem associated with both an increased risk of death and an increased risk of cardiovascular events."( Ali, MK; Byrne, JP; Clarke, K; Francis, JM; Neubauer, S; Rider, OJ; Robinson, MR; Tayal, U, 2010)
"Obesity is a multifactorial disease that is influenced by genetic and environmental factors."( Bideci, A; Camurdan, O; Cinaz, P; Ergun, MA; Karaoguz, MY; Koc, A; Yazici, AC, 2010)
"Overweight and obesity is a health threat of increasing concern and understanding the neurobiology behind obesity is instrumental to the development of effective treatment regimes."( Erritzoe, D; Frokjaer, VG; Haahr, MT; Hansen, DL; Holst, KK; Jernigan, TL; Kalbitzer, J; Knudsen, GM; Lehel, S; Svarer, C, 2010)
"Obesity is accompanied by disturbances in glucocorticoid metabolism, circulating adipokine levels, and fatty acid (FA) reesterification."( Angelhed, JE; Lönn, L; Mattsson, C; Näslund, I; Olsson, T; Rask, E; Simonyte, K, 2010)
"Obesity is a risk factor for stroke, but the determinants of increased stroke risk in obesity are unknown."( Mintz, JD; Osmond, JM; Stepp, DW, 2010)
"Obesity is associated with an increased risk of diabetes, cardiovascular events, stroke and cancer."( Bloom, SR; Minnion, JS; Shillito, JC; Simpson, KA; Suzuki, K, 2010)
"Obesity is becoming a global epidemic."( Gomes, F; Halpern, A; Nicolau, JC; Serrano, CV; Souza, HP; Telo, DF, 2010)
"Obesity is a public health problem, with overweight individuals representing approximately 20% of the adult world population."( Brincat, M; Erel, CT; Gambacciani, M; Lambrinoudaki, I; Moen, MH; Rees, M; Rozenberg, S; Schenck-Gustafsson, K; Tremollieres, F; Vujovic, S, 2010)
"Obesity is considered to be a risk factor for prostate cancer."( Fischer, K; Fornara, P; Hamza, A; Heynemann, H; Hoda, MR; Schneider, J; Wagner, S, 2010)
"Obesity is a major risk factor for a variety of illnesses, and an increase in obesity is, therefore, implicated in increased health-care costs in the United States."( Neymotin, F; Sen, U, 2011)
"Obesity is associated with an increase in adipose tissue mass due to an imbalance between high dietary energy intake and low physical activity; however, the type of dietary protein may contribute to its development."( Frigolet, ME; Jimenez-Sanchez, G; Rangel, C; Torres, N; Tovar, AR; Uribe-Figueroa, L, 2011)
"Obesity is associated with the impairment of immunological functions."( Balistreri, CR; Candore, G; Caruso, C; Di Vita, G; Famà, F; Patti, R, 2010)
"Obesity is frequently associated with endothelial dysfunction."( Ketonen, J; Mervaala, E; Pilvi, T, 2010)
"Obesity is intimately associated with hypertension; increases in blood pressure are closely related to the magnitude of weight gain."( Dewa, A; Suhaimi, FW; Yusof, AP; Yusoff, NH, 2010)
"Human obesity is closely associated with a state of chronic low-grade inflammation, which also involves the adipose tissue with enhanced production of bioactive substances (adipokines)."( Cullberg, KB; Olholm, J; Paulsen, SK; Pedersen, SB; Richelsen, B, 2010)
"Obesity is a major risk factor for the development of hypertension."( Danser, JA; Jansen, PM; Spiering, W; van den Meiracker, AH, 2010)
"Although obesity is associated with leptin resistance, we hypothesized that under fasting conditions, leptin sensitivity might be restored and that hyperleptinemia may counteract the neuronal response to fasting."( Becskei, C; Lutz, TA; Riediger, T, 2010)
"Obesity is a risk factor for venous disease."( Allison, MA; Callas, PW; Criqui, MH; Cushman, M; Denenberg, JO; Jensky, NE, 2010)
"Childhood obesity is a growing problem worldwide."( Baroni, MG; Cambuli, VM; Congiu, T; Cossu, E; Huang-Doran, I; Incani, M; Loche, S; Matta, V; Pilia, S; Romeo, S; Sentinelli, F, 2010)
"given that obesity is an independent risk factor for the development of cardiovascular diseases we decided to investigate the mechanisms involved in microvascular dysfunction using a monosodium glutamate (MSG)-induced model of obesity, which allows us to work on both normotensive and normoglycemic conditions."( Akamine, EH; Carvalho, MH; Davel, AP; Filgueira, FP; Fortes, ZB; Lobato, NS; Rossoni, LV; Tostes, RC, 2011)
"Obesity is characterized by the accumulation of fat in the liver and other tissues, leading to insulin resistance."( Arbeeny, CM; Cheng, SH; Hong, EG; Jiang, C; Kim, JK; Przybylska, M; Shayman, JA; Siegel, C; Wu, IH; Yew, NS; Zhao, H, 2010)
"Obesity is a major health crisis worldwide and new treatments are needed to fight this epidemic."( Gu, W; Kong, X; Li, X; Liu, Z; Smith, SB; Tan, B; Tang, W; Wu, G; Xu, H; Yao, K; Yin, Y, 2011)
"Since obesity is associated with a hypercoagulable state, it has been speculated that hypercoagulation is linking MetS to CVD."( Fritsch, M; Fritsch, P; Kleber, M; Mangge, H; Muntean, W; Reinehr, T; Rosenkranz, A, 2010)
"Obesity is a major health problem world-wide."( Asnaashari, S; Delazar, A; Habibi, B; Hamedeyazdan, S; Nahar, L; Sarker, SD; Vasfi, R, 2010)
"In accordance with obesity is associated with insulin resistance and dyslipidemia and chitosan decrease weight and lipids, but its effect on insulin sensitivity is unknown."( González-Ortiz, M; Hernández-González, SO; Martínez-Abundis, E; Robles-Cervantes, JA, 2010)
"Obesity is an epidemic problem affecting millions of people in the Western hemisphere and costs the United States economy more than $200 billion annually."( Barrett, CM; Dalton, JT; Eswaraka, J; Kearbey, JD; Miller, DD; Narayanan, R; Raghow, S; Veverka, KA; Yepuru, M, 2010)
"The rates of dog obesity are increasing and a greater understanding of feeding patterns is required to combat the problem."( Heuberger, R; Wakshlag, J, 2011)
"The causes of obesity are well-known and involve the overconsumption of calories from all sources."( Rippe, JM, 2010)
"Obesity is associated with overactivity of the endocannabinoid system, which is involved in the regulation of appetite, lipogenesis, and insulin resistance."( Ambudkar, SV; Bátkai, S; Godlewski, G; Kunos, G; Liu, J; Makriyannis, A; Mukhopadhyay, B; Ohnuma, S; Osei-Hyiaman, D; Pickel, J; Tam, J; Vemuri, VK, 2010)
"Obesity is associated with gastroesophageal reflux disease (GERD)."( Jeon, SW; Jung, MK; Kwon, JG; Lee, MH, 2010)
"Obesity is characterised by altered gut microbiota, low-grade inflammation and increased endocannabinoid (eCB) system tone; however, a clear connection between gut microbiota and eCB signalling has yet to be confirmed."( Bäckhed, F; Cani, PD; Delzenne, NM; Lambert, DM; Muccioli, GG; Naslain, D; Reigstad, CS, 2010)
"Obesity is associated with a high risk of coronary artery disease morbidity and mortality."( Biasucci, LM; Brugaletta, S; Crea, F; De Caterina, AR; Graziani, F; Guidone, C; Liuzzo, G; Mingrone, G; Rizzello, V, 2010)
"Obesity is associated with reduced testosterone and growth hormone (GH)."( Connelly, JM; Grinspoon, SK; Hemphill, LC; Makimura, H; Stanley, TL; Sun, N, 2010)
"childhood obesity is a risk factor for many perioperative complications."( Blum, J; Cowan, A; Kheterpal, S; Maclean, S; Nafiu, OO; Tremper, KK, 2010)
"Obesity is the most crucial risk factor of metabolic syndrome, because it is known to precede other risk factors."( Cai, G; Freeland-Graves, JH; Jordan, KC; Klohe, DM; Lane, MA; Voruganti, VS, 2010)
"Obesity is currently an epidemic across the globe."( Ahmed, MH, 2010)
"Obesity is associated with many diseases, particularly diabetes, hypertension, osteoarthritis, and heart disease."( Yun, JW, 2010)
"Obesity is associated with chronic inflammation and contributes to the development of insulin resistance and nonalcoholic fatty liver disease."( Andrikopoulos, S; Dzamko, N; Fam, BC; Fynch, S; Galic, S; Hevener, AL; Honeyman, J; Kay, TW; Proietto, J; Sachithanandan, N; Steinberg, GR; Watt, MJ; Wormald, S, 2010)
"Obesity is associated with an increased incidence of many cancers, including leukemia, although it is unknown whether leukemia incidence is increased directly by obesity or rather by associated genetic, lifestyle, health, or socioeconomic factors."( Behan, JW; Butturini, A; Groffen, J; Heisterkamp, N; Ji, L; Klemm, L; Mittelman, SD; Müschen, M; Yun, JP, 2010)
"Obesity is associated with a host of metabolic challenges, collectively termed the metabolic syndrome."( Adeli, K; Baker, C; Dekker, MJ; Rutledge, AC; Su, Q, 2010)
"Obesity is a frequent manifestation of hypothalamic damage from a craniopharyngioma (CP)."( Björk, J; Ekman, B; Erfurth, EM; Holmer, H; Popovic, V; Pozarek, G; Wirfält, E, 2010)
"Obesity is an emerging public health threat in the elderly population in developing countries."( Ahmad Ali, Z; Ahmad Fauzi, Y; Geeta, A; Jamaiyah, H; Jamaludin, AR; Kee, CC; Khor, GL; Noor Safiza, MN; Rahmah, R; Ruzita, AT; Suzana, S, 2012)
"Obesity is primarily considered to be a disorder of energy balance, and it has recently been suggested that some forms of obesity are associated with chronic low-grade inflammation."( Nakayama, T; Wang, Z, 2010)
"The prevalence of obesity is increasing with an alarming rate worldwide and there is a need for efficacious satiety drugs."( Artmann, A; Chelur, S; Holst, B; Jensen, KJ; Pedersen, SL; Sasikumar, PG; Vrang, N, 2010)
"Obesity is a pathological condition affecting a growing number of people especially in the Western countries resulting from the failure of the organism's energetic balance based on the perfect equality of income, waste, and storage."( Campanale, M; Gasbarrini, A; Lauritano, EC; Leone, D; Purchiaroni, F; Scarpellini, E; Vitale, G, 2010)
"However, obesity is most often associated with elevated plasma leptin levels and leptin resistance."( Briancon, N; Flier, JS; Maratos-Flier, E; McNay, DE, 2010)
"Obesity is associated with an increased risk of breast cancer in postmenopausal women."( Caldefie-Chézet, F; Jardé, T; Perrier, S; Vasson, MP, 2011)
"Obesity is an important risk factor of atherosclerosis and its prevalence in humans is increasing."( Akpınar, O; Demirbağ, R; Sezen, Y; Söylemez, N; Yıldız, A, 2010)
"Obesity is increasingly prevalent in affluent societies and portends considerable morbidity."( Barr, RD; Collins, L; Nayiager, T; Pollock, BH; Zarzabal, LA, 2010)
"Childhood obesity is associated with unfavorable lipid profile."( Kapil, U; Kaur, S, 2011)
"Diabetic obesity is associated with increased fracture risk in adults and adolescents."( Ager, JW; Alliston, T; Ionova-Martin, SS; Lane, NE; Ritchie, RO; Shahnazari, M; Tang, S; Vaisse, C; Wade, JM; Yao, W, 2011)
"Obesity is rapidly becoming a pandemic and is associated with increased carcinogenesis."( Anania, FA; Cohen, C; Fu, PP; Handy, J; Mells, J; Nagalingam, A; Page, AJ; Saxena, NK; Sharma, D; Sharma, S; Wang, J, 2010)
"Obesity is a risk factor for the development of chronic kidney disease (CKD) and end-stage renal disease."( Correa-Rotter, R; Cruz, C; Hernández-Pando, R; Pedraza-Chaverri, J; Salas-Garrido, G; Torres, N; Tovar, AR; Tovar-Palacio, C, 2011)
"Obesity is a risk factor for atherosclerosis, a polyvascular process associated with reduced survival."( Bax, JJ; Chonchol, M; Flu, WJ; Galal, W; Goei, D; Poldermans, D; van Kuijk, JP; Verhagen, HJ, 2011)
"Obesity is a prevalent disorder characterized as marked insulin resistance and low grade inflammation."( Abdelsayed, R; El-Marakby, A; El-Salanty, M; Liu, JY; Mozaffari, MS; Wimborne, H; Zakhary, I, 2011)
"Central obesity is associated with low-grade inflammation that promotes type 2 diabetes and cardiovascular disease in obese individuals."( Bevard, MH; Chakrabarti, SK; Cole, BK; Dobrian, AD; Gu, J; Keller, SR; Ma, Q; Nadler, JL; Pei, H; Vandenhoff, GE; Wen, Y; Williams, MD, 2011)
"Obesity is associated with an increased risk of developing insulin resistance, hyperinsulinemia, glucose intolerance, dyslipidemia, hypertension, premature atherosclerosis, and coronary artery disease."( Ayhan, S; Demir, K; Erdem, S; Karabag, T; Kaya, A; Kaya, C; Koc, F; Tokac, M; Unlu, A; Vatankulu, MA, 2010)
"Obesity is linked to systemic oxidative stress and, although brown adipose tissue (BAT) plays a crucial role in energy balance, BAT redox status effects on obesity have not been studied previously."( Gianotti, M; Llad, I; Nadal-Casellas, A; Proenza, AM, 2011)
"Obesity is characterized by the accumulation of triacylglycerol in adipocytes."( Aicher, TD; Kato, K; Kitamura, S; Miki, H; Nakada, Y; Pratt, SA; Yamaguchi, H; Yamamoto, T, 2011)
"Obesity is a growing worldwide health problem affecting both adults and children."( Arslan, N; Aydin, A; Erdur, B, 2010)
"Obesity is associated with low-grade inflammation contributing to insulin-resistance."( Brignardello, J; Brunser, O; Diaz, E; Gotteland, M; Morales, P; Romero, J, 2010)
"Obesity is the effect of imbalance between energy intake and expenditure and forms a fundamental basis of the metabolic syndrome."( Masaki, T; Yoshimatsu, H, 2010)
"Diet-induced obesity is associated with changes in gastrointestinal function and induction of a mild inflammatory state."( Bertrand, PP; Bertrand, RL; Chen, H; Howitt, L; Liu, L; Markus, I; Murphy, TV; Sandow, SL; Senadheera, S, 2011)
"Obesity is a risk factor for diabetes and cardiovascular disease, but little is known about the relationship between OPG and obesity."( Ashley, DT; Crowley, RK; Davenport, C; Devlin, N; McCaffrey, N; Moyna, NM; O'Gorman, DJ; O'Sullivan, EP; Smith, D, 2011)
"The incidence of obesity is increasing worldwide and is hence considered a major public health concern."( Alappat, L; Awad, AB, 2010)
"Obesity is one of the most serious common somatic adverse effects of atypical antipsychotic agents."( Cohen, D; Egberts, TC; Gregoor, JG; Heerdink, ER; Mulder, H; van der Weide, J; van Megen, HJ, 2010)
"Obesity is associated with resistance to the actions of both leptin and insulin via mechanisms that remain incompletely understood."( Anderson, GM; Augustine, RA; Benzler, J; Ganjam, GK; Grattan, DR; Koch, C; Lowe, C; Pracht, C; Schwartz, MW; Shepherd, PR; Steger, J; Tups, A, 2010)
"Obesity is one of the most important modifiable risk factors for the prevention of type 2 diabetes."( Lane, J; Nguyen, NT; Nguyen, XM; Wang, P, 2011)
"Obesity is a well-established risk factor for the development and progression of coronary heart disease."( Endo, M; Nagashima, H, 2011)
"Obesity is a serious health problem and its prevalence has increased over the years."( Lacerda, FV; Oliveira, HP; Rodrigues, MR, 2011)
"Obesity is a risk factor for the development of esophageal malignancy."( Mathew, J; Odell, JA; Stauffer, JA, 2011)
"Mendelian forms of obesity are already known to account for approximately 5% of the severely obese but are currently underinvestigated."( Blakemore, AI; Froguel, P, 2010)
"Obesity is a central pathological mechanism in the disease and it is expected that the incidence of this condition will increase dramatically within the next years."( Blankenberg, S; Espinola-Klein, C; Gori, T; Munzel, T, 2011)
"Since obesity is a highly prevalent condition that is critically dependent on food intake and energy expenditure, a deeper understanding of gustatory processing is an important objective in biomedical research."( Nicolelis, MA; Oliveira-Maia, AJ; Roberts, CD; Simon, SA, 2011)
"Obesity is known to be the most common cause of simple steatosis in the preadolescent and adolescent population with a consequent serious health risk."( Álvarez Ferre, J; González Jiménez, E; Schmidt Río-Valle, J, 2011)
"Obesity is linked to chronic inflammation in white adipose tissue, which is exacerbated by infiltrating macrophages (MΦs)."( Chuang, CC; McIntosh, M; Overman, A, 2011)
"Obesity is a tremendous public health problem, characterized by ectopic accumulation of fat into non-adipose tissues, leading to oxidative stress and chronic inflammation, in which the heart is the most severely affected organ."( Aouani, E; Ben Hassine, F; Charradi, K; Elkahoui, S; Limam, F; Sebai, H, 2011)
"Obesity is associated with increased cardiovascular morbidity and mortality."( Celoria, BM; da Silva, EG; de Abreu, VG; Francischetti, EA; Rodrigues, E; Tibirica, E, 2011)
"Obesity is associated with a chronic inflammatory state characterized by adipose tissue macrophage infiltration and inflammation, which contributes to insulin resistance."( Shi, H; Wang, X; Xue, B; Yang, Z, 2011)
"Obesity is a factor in the outcome and severity of pancreatic conditions."( Alloosh, M; Bell, LN; Chalasani, N; Fullenkamp, AM; Klaunig, JE; Lee, L; Mirmira, RG; Robbins, RD; Saxena, R; Sturek, M, 2011)
"Obesity is caused by disturbances of energy balance, which is homeostasized by the physiological processes."( Pandey, A; Pandey, HP; Pratyush, DD; Shukla, HS; Singh, AK; Singh, HK; Tewari, M, 2011)
"Obesity is likely under-diagnosed using the standard WHO and NCEP-ATPIII guidelines."( Mandayam, S; Omegie, LA; Stotts, AL; Vasudevan, D, 2011)
"The prevalence of obesity is growing rapidly worldwide, and therefore there is a need for effective treatment strategies."( Hatzitolios, AI; Katsiki, N; Mikhailidis, DP, 2011)
"Obesity is the main risk factor for type 2 diabetes mellitus, and recent studies have shown that, in diet-induced obesity, the hypothalamus becomes inflamed and dysfunctional, resulting in the loss of the perfect coupling between caloric intake and energy expenditure."( Araújo, EP; Boschero, AC; Calegari, VC; Morari, J; Sbragia, L; Torsoni, AS; Vanzela, EC; Velloso, LA; Zoppi, CC, 2011)
"Obesity is a growing epidemic characterized by excess fat storage in adipocytes."( Bu, G; Herz, J; Kolber, BJ; Liu, Q; Muglia, LJ; Zerbinatti, C; Zhan, Y; Zhang, J, 2011)
"Obesity is a chronic disease with a high prevalence in both developed and developing countries."( Bai, B; Wang, Y, 2010)
"Obesity is receiving growing research attention."( Chao, JK; Chen, YP; Hwang, TI; Kuo, WH; Lin, YC; Liu, JH; Ma, MC, 2011)
"Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that contribute to the development of insulin resistance."( de Graaf, J; Joosten, LA; Koenen, TB; Netea, MG; Stalenhoef, AF; Stienstra, R; Tack, CJ; van Tits, LJ, 2011)
"Childhood obesity is an emerging national health problem in Thailand."( Kiattisakthavee, P; Likitmaskul, S; Nakavachara, P; Numbenjapon, N; Santiprabhob, J; Wongarn, R, 2010)
"Obesity is one of the major risk factors for type 2 diabetes, and the development of agents, that can simultaneously achieve glucose control and weight loss, is being actively pursued."( Bianchi, E; Bonelli, F; Bufali, S; Capitò, E; Carrington, PE; Cianetti, S; Finotto, M; Ingallinella, P; Langella, A; Marsh, DJ; Monteagudo, E; Pessi, A; Pocai, A; Santoprete, A; Sinharoy, R; Veneziano, M; Zhu, L; Zytko, K, 2011)
"Obesity is a serious international health problem that increases the risk of several diet-related chronic diseases."( Hayashi, Y; Kanou, Y; Murata, Y; Sun, XY; Takagishi, Y; Tang, YP; Xu, S, 2011)
"Common obesity is characterized by the over-consumption of palatable/rewarding foods, reflecting an imbalance in the relative importance of hedonic versus homeostatic signals."( Alvarez-Crespo, M; Dickson, SL; Egecioglu, E; Engel, JA; Friberg, PA; Hansson, C; Jerlhag, E; Skibicka, KP, 2011)
"Obesity is epidemic and is clearly an independent risk factor for increased severity of acute pancreatitis (AP)."( Al-Azzawi, HH; Pitt, HA; Swartz-Basile, DA; Wade, TE; Wang, S; Zyromski, NJ, 2011)
"Obesity is a major risk factor for incident heart failure (HF)."( Anand, IS; Carson, PE; Haass, M; Kitzman, DW; Massie, BM; Miller, A; Zile, MR, 2011)
"Obesity is common in HFPEF patients and is accompanied by multiple differences in clinical characteristics."( Anand, IS; Carson, PE; Haass, M; Kitzman, DW; Massie, BM; Miller, A; Zile, MR, 2011)
"Although obesity is recognized as a global health epidemic, insufficient research has been directed to understanding the rising prevalence of obesity in the fastest growing segment of the population, older adults."( Green, E; Haase, L; Jacobson, A; Murphy, C, 2011)
"Obesity is associated with vascular dysfunction."( Drexel, V; Emslander, I; Halle, M; Hanssen, H; Hertel, G; Kotliar, KE; Lorang, D; Nickel, T; Pressler, A; Schmidt-Trucksäss, A; Schuster, T; Sisic, Z; Weis, M, 2011)
"Obesity is rapidly becoming a worldwide epidemic that affects children and adults."( Bellentani, FF; Cicogna, AC; Favareto, AP; Fernandes, GS; Fernandez, CD; Kempinas, WD; Nascimento, AF; Perobelli, JE, 2011)
"Obesity is common and associated with a high rate of morbidity and mortality; therefore, treatment is of great interest."( Holst, JJ; Madsbad, S; Torekov, SS, 2011)
"Obesity is a risk factor for atherosclerotic vascular disease."( Aust, G; Blüher, M; Richter, O; Rohm, S; Scholz, M; Uptaite-Patapoviene, M, 2011)
"Obesity is highly prevalent in Western populations and is considered a risk factor for the development of renal impairment."( Andrikopoulos, S; Bierhaus, A; Chand, V; Cooper, ME; Coughlan, MT; de Courten, B; de Courten, MP; Dougherty, SL; Forbes, JM; Harcourt, BE; Kingwell, BA; Morley, AL; Penfold, SA; Sourris, KC; Thallas-Bonke, V; Thomas, MC; Walker, KZ, 2011)
"Obesity is a multifactorial disease characterized by an excessive weight for height due to an enlarged fat deposition such as adipose tissue, which is attributed to a higher calorie intake than the energy expenditure."( Boque, N; Campión, J; de la Garza, AL; Martínez, JA; Milagro, FI, 2011)
"Although obesity is a common co-morbid condition in COPD, relatively little is known how it may affect functional exercise capacity."( Bautista, J; Ehsan, M; Lahiri, B; Normandin, E; Zuwallack, R, 2011)
"Diet-induced obesity is reported to induce a phenotypic switch in adipose tissue macrophages from an antiinflammatory M2 state to a proinflammatory M1 state."( Aminuddin, A; Bukhari, A; Fujisaka, S; Ikutani, M; Kanatani, Y; Kobayashi, M; Nagai, Y; Senda, S; Suzuki, H; Tabuchi, Y; Takasaki, I; Takatsu, K; Tobe, K; Tsuneyama, K; Usui, I; Yamazaki, Y, 2011)
"Because obesity is highly stigmatized, any effective treatment should be made available to improve quality of life and self-image."( Sakane, N, 2011)
"Obesity is a global public health challenge that increases the risk of various diseases including type 2 diabetes mellitus, hypertension and cancer, and will in the future cause further increases in the incidence of chronic disease."( Dyrstad, SM; Foss, B, 2011)
"In conclusion, obesity is associated with an enhanced TLR response in patients suffering from established atherosclerotic disease."( de Kleijn, DP; de Vries, JP; Doevendans, PA; Hoefer, IE; Moll, FL; Pasterkamp, G; Scholtes, VP; Schoneveld, AH; Stella, PR; van Keulen, KJ; Versteeg, D, 2011)
"Obesity is recently known as a risk factor for endoscopic gastritis."( Fujimoto, T; Furubayashi, A; Hamasaki, T; Hayashi, N; Kamada, Y; Kato, M; Kihara, S; Kinoshita, K; Kishida, O; Kiso, S; Matsuzawa, Y; Tsukamoto, Y; Tsutsui, S; Umeda, M; Watabe, K; Yamada, A; Yamamoto, S; Yoshida, Y, 2011)
"Since obesity is associated with increased cardiovascular (CV) medication use and pharmaceutical costs, weight-loss drug use could beneficially impact CV medication use."( Czernichow, S; Fezeu, L; Grobbee, DE; Knol, MJ, 2012)
"Obesity is a world wide epidemic; it is becoming more usual to be overweight or obese than to be normal weight."( Bennetzen, MF, 2011)
"Obesity is associated with poor neurocognitive outcome including impaired hippocampal synaptic plasticity and cognitive abilities such as learning and memory."( Delibas, N; Hicyilmaz, H; Sirmali, R; Sutcu, R; Vural, H; Yilmaz, M; Yilmaz, N, 2011)
"Obesity is associated with increased markers of oxidative stress."( Abumrad, NA; Abumrad, NN; El-Rifai, W; Hajri, T; Jabbour, K; Marks-Shulman, PA; Peng, D; Saliba, J; Shukrallah, B; Tamboli, RA; Ueda, Y, 2011)
"Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes."( Allison, DB; Day, WW; Gadde, KM; Peterson, CA; Ryan, DH; Schwiers, ML; Troupin, B, 2011)
"Obesity is a risk factor for asthma and type II diabetes."( Hwang, SJ; Jung, HL; Kim, DS; Kim, JH; Kim, SY; Lee, WY; Park, MS; Shim, JW; Shim, JY, 2011)
"Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease."( Bikman, BT; Bulchand, S; Clegg, DJ; Holland, WL; Knotts, TA; Pagliassotti, MJ; Sargent, KM; Scherer, PE; Shui, G; Summers, SA; Wang, LP; Wenk, MR; Yuguang, G, 2011)
"Obesity is associated with an altered GH/IGF-I axis status, accounting for the increased cardiovascular risk in obese subjects with GH deficiency."( Cipriano, P; Colao, A; De Rosa, A; Di Somma, C; Lombardi, G; Nedi, V; Patti, L; Pizza, G; Rivellese, A; Rossi, A; Savastano, S, 2011)
"Worldwide obesity is a growing health problem, associated with increased risk of chronic disease."( Choi, MS; McGregor, RA, 2011)
"Obesity is associated with insulin resistance in the peripheral vasculature and is an important risk factor for coronary artery disease."( Andriantsitohaina, R; Contreras, C; García-Sacristán, A; Martínez, MC; Prieto, D; Sánchez, A, 2011)
"Moreover, obesity is associated with ectopic lipid deposition even in the heart, which may directly exert a lipotoxic effect on the myocardium by secreting in loco several cytokines and adipokines."( Clerico, A; Emdin, M; Giannoni, A; Vittorini, S, 2012)
"Obesity is commonly associated with diabetes, cardiovascular diseases and cancer."( Aikawa, J; Borghetti, G; Brito, GA; Coelho, I; Fernandes, LC; Iagher, F; Kryczyk, M; Machado, J; Naliwaiko, K; Nunes, EA; Pequitto, DC; Rocha, RE; Schiessel, DL; Tanhoffer, RA; Yamaguchi, AA; Yamazaki, RK, 2011)
"Obesity is common among persons with arthritis (2) and is a modifiable risk factor associated with progression of arthritis, activity limitation, disability, reduced quality-of-life, total joint replacement, and poor clinical outcomes after joint replacement (4,5)."( , 2011)
"Obesity is caused by an imbalance between energy intake and expenditure and has become a major health-care problem in western society."( Adan, RA; Bergen, DJ; Brakkee, JH; Brans, MA; Cuppen, E; Garner, KM; Mul, JD; Toonen, PW; van Boxtel, R, 2012)
"Obesity is associated with both reduced growth hormone (GH) and adiponectin."( Branch, KL; Chen, CY; Grinspoon, SK; Makimura, H; Stanley, TL, 2011)
"Obesity is a major risk factor for the development of type 2 diabetes, and both conditions are now recognized to possess significant inflammatory components underlying their pathophysiologies."( Guo, H; Ling, W; Xia, M; Zhang, W; Zhong, R; Zou, T, 2012)
"Obesity is a major cause of metabolic syndrome and is due to an increase in the number and hypertrophy of adipocytes."( Ikarashi, N; Ito, K; Ochiai, W; Sugiyama, K; Suzuki, K; Tajima, M; Toda, T, 2012)
"Obesity is an independent cardiovascular (CV) risk factor."( Balzi, D; Corona, G; Forti, G; Maggi, M; Mannucci, E; Melani, C; Monami, M; Rastrelli, G; Sforza, A, 2011)
"Obesity is strongly associated with the development of non-alcoholic fatty liver disease (NAFLD)."( Hrabé de Angelis, M; Kahle, M; Kenner, L; Kiefer, FW; Legerer, B; Mair, M; Neschen, S; Neuhofer, A; Pfau, B; Plutzky, J; Schlederer, M; Stulnig, TM; Zeyda, M, 2011)
"Childhood obesity is an important risk factor for the development of insulin resistance (IR) and its co-morbidities."( Galván-Duarte, R; Medina-Bravo, P; Meza-Santibáñez, R; Rosas-Fernández, P; Saucedo-García, R; Torres-Tamayo, M; Velázquez-López, L, 2011)
"Obesity is a worldwide epidemic and there is an urgent need for the development of effective pharmacological therapies that target the metabolic and behavioral factors of body weight regulation."( Ravussin, E; Redman, LM, 2010)
"Adults with obesity are less likely than adults without obesity to follow physical activity recommendations, despite the known benefits of physical activity for weight loss and weight maintenance)."( , 2011)
"Obesity is a highly prevalent health problem in Western countries that leads to many important diseases such as type 2 diabetes and metabolic syndrome being now considered an inflammatory chronic disease."( Alvarez, R; Cuesta, N; Fresno, M, 2011)
"Obesity is associated with induction of the ER (endoplasmic reticulum)-stress response signalling and insulin resistance."( Agouni, A; Bence, KK; Bentires-Alj, M; Czopek, A; Delibegović, M; Mody, N; Owen, C; Zimmer, D, 2011)
"The incidence of obesity is increasing at an alarming rate and this worldwide epidemic represents a significant decrease in life span and quality of life of a large part of the affected population."( Dickson, SL; Skibicka, KP, 2011)
"Obesity is a significant risk factor for surgical site infections (SSIs), for poorly understood reasons."( Kharasch, E; London, A; Mutch, M; Stefanescu, A; Suntrup, P; Toma, O, 2011)
"Obesity is common among reproductive age women and is associated with adverse pregnancy and fetal outcomes; however, little is known about the effects of excess FFAs on embryos and subsequent fetal development."( Chi, MM; Frolova, AI; Jungheim, ES; Louden, ED; Moley, KH; Riley, JK, 2011)
"Obesity is one of the most prevalent health problems in the United States."( Chen, JD; Sallam, HS, 2011)
"Obesity is an independent risk factor for severe acute pancreatitis, though the mechanisms underlying this association are unknown."( Al-Azzawi, HH; Pitt, HA; Swartz-Basile, DA; Wang, S; Ziegler, KM; Zyromski, NJ, 2011)
"Obesity is associated with a variety of chronic diseases, including cancer, which may partly be explained by its influence on sex steroid hormone concentrations."( Feinleib, M; Guallar, E; Joshu, CE; Kanarek, N; Lopez, DS; Menke, A; Nelson, WG; Platz, EA; Rifai, N; Rohrmann, S; Shiels, MS; Sutcliffe, S, 2011)
"Obesity is a chronic disease of multifactorial origin and can be defined as an increase in the accumulation of body fat."( Bautista, M; Durante-Montiel, I; Esquivel-Chirino, C; Esquivel-Soto, J; Fernández-Sánchez, A; Madrigal-Santillán, E; Morales-González, A; Morales-González, JA; Sánchez-Rivera, G; Valadez-Vega, C, 2011)
"Childhood obesity is a major health problem."( Delemarre-van de Waal, HA; Luman, M; Malik, JA; Oosterlaan, J; Pieterse, K; van den Berg, L; Willems van Dijk, K, 2011)
"We conclude that obesity is characterized by increased Mch responsiveness, predominantly of the small airways, due to a DI effect that renders the airways more sensitive to the stimulus."( Desai, A; Schechter, C; Skloot, G; Togias, A, 2011)
"Obesity is also associated with pathophysiological changes that can affect the pharmacokinetics of drugs."( Bochud, M; Burnier, M; Giusti, V; Wuerzner, G, 2011)
"Obesity is characterized by a low-grade inflammation in white adipose tissue (WAT), which promotes insulin resistance."( Arner, P; Aström, G; Carlberg, C; Dahlman, I; Dunlop, T; Eriksson, A; Hedén, P; Laurencikiene, J; Lorente-Cebrián, S; Mejhert, N; Rydén, M; Sjölin, E; Wåhlén, K, 2012)
"Obesity is a major risk factor for the development and progression of breast cancer."( Andò, S; Bonofiglio, D; Bossi, G; Catalano, S; Mauro, L; Pellegrino, M; Qi, H; Rizza, P; Vizza, D, 2011)
"Obesity is a risk factor for heart failure (HF)."( Carrasco, FJ; Casado, J; Ceresuela, LM; Conde, A; Díez, J; Formiga, F; Montero, M; Trullàs, JC, 2011)
"Obesity is a chronic disease of multiple etiologies, including genetic, metabolic, environmental, social, and other factors."( Cardoso, MR; Ferreira, GK; Gomes, LM; Jeremias, IC; Martinello, OB; Morais, MO; Quevedo, J; Rezin, GT; Streck, EL; Valvassori, SS, 2011)
"Obesity is associated with a low-grade state of chronic inflammation that might be causally related to cardiometabolic disease."( Apovian, CM; Bigornia, S; Farb, MG; Freedman, JE; Gokce, N; Hess, DT; Joseph, L; Morin, KM; Mott, M; Tanriverdi, K; Vita, JA, 2011)
"Visceral obesity is characterized by endothelial dysfunction."( Anselmino, M; Bernardini, N; Blandizzi, C; Colucci, R; Duranti, E; Pinchera, A; Rugani, I; Salvetti, A; Salvetti, G; Santini, F; Segnani, C; Taddei, S; Virdis, A, 2011)
"Obesity is associated with a systemic, low-grade inflammatory state."( Adorini, L; Baldi, E; Colpi, GM; Corona, G; Degli Innocenti, S; Filimberti, E; Forti, G; Lotti, F; Maggi, M; Mancini, M; Noci, I, 2011)
"Obesity is a major health problem worldwide."( Cheung, BM, 2011)
"Although obesity is known to increase cardiovascular disease risk through inducing metabolic abnormalities such as dyslipidemia, hypertension, and inflammation, it is also a strong predictor of subclinical atherosclerosis progression in adults with T1D independent of these factors."( Haarhues, MD; Kinney, GL; Rewers, M; Rodrigues, TC; Snell-Bergeon, JK; Veyna, AM, 2011)
"Obesity is an independent risk factor for primary graft dysfunction after lung transplantation."( Arcasoy, SM; Bhorade, S; Christie, JD; Crespo, M; Diamond, JM; Kawut, SM; Lama, VN; Lederer, DJ; Lee, J; Orens, JB; Palmer, SM; Sonett, JR; Ware, LB; Weinacker, A; Wickersham, N; Wille, KM; Winterbottom, C, 2011)
"In fact, obesity is the body's way of storing lipids where they belong, in fat tissue, to protect our other organs from lipids toxic effects."( Fodor, M, 2011)
"Obesity is associated with an increased risk of development and recurrence of colorectal cancer."( Derleyn, VA; Koopman, M; Mol, L; Muller, EW; Punt, CJ; Simkens, LH; Teerenstra, S; Ten Bokkel Huinink, D; Veldhuis, GJ, 2011)
"Obesity is characterized by chronic low-grade inflammation, which contributes to insulin resistance."( Kirchgessner, A; Lakhan, SE, 2011)
"Obesity is associated to significant disturbances in endocrine function."( Álvarez-Castro, P; Brandón-Sandá, I; Cordido, F; Sangiao-Alvarellos, S, 2011)
"Obesity is commonly associated with hypertension."( Gao, J; Hasegawa, Y; Imai, J; Ishigaki, Y; Kaneko, K; Katagiri, H; Matsusue, K; Oka, Y; Uno, K; Yamada, T; Yamazaki, T, 2012)
"Obesity is associated with insulin resistance, liver steatosis and low-grade inflammation."( Holcomb, VB; Hong, J; Najjar, K; Núñez, NP; Stubbins, RE, 2012)
"Because obesity is associated with breast cancer progression, it is important to determine whether dietary fat per se stimulates breast cancer progression in the absence of obesity."( Choi, MR; Chun, HS; Hong, JE; Kim, EJ; Kim, M; Lee, JY; Lee, KW; Park, H; Yoon Park, JH, 2011)
"Postmenopausal obesity is associated with elevated serum IMA possibly due to obesity associated oxidative stress."( Dalamaga, M; Dionyssiou-Asteriou, A; Jullien, G; Kassi, E; Kazanis, K; Manolis, AS; Merantzi, G; Nounopoulos, C, 2011)
"Obesity is a risk factor for both cardiovascular disease and cancer development."( Cugino, D; Cutrone, A; de Gaetano, G; Donati, MB; Iacoviello, L; Latella, MC; Lorenzet, R; Napoleone, E; Zurlo, F, 2012)
"Obesity is associated with high levels proinflammatory cytokines like tumour necrosis factor alpha (TNF-α), which may play an important role in the genesis of insulin resistance."( Bhatt, SP; Bhushan, B; Guleria, R; Luthra, K; Misra, A; Pandey, RM; Poddar, PK; Vikram, NK, 2011)
"Obesity is also an increasingly serious problem in dog breeding."( Fijak-Nowak, H; Grzes, M; Switonski, M; Szczerbal, I; Szydlowski, M, 2011)
"1."( Konstantinides, S; Schäfer, K, 2011)
"As obesity is associated with an increased risk of venous thromboembolism and arterial disease, there is an urgent need to establish appropriate anticoagulation regimens for this patient group."( Arya, R; Patel, JP; Roberts, LN, 2011)
"Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes."( Enomoto, T; Higuchi, A; Izumiya, Y; Maruyama, S; Murohara, T; Ohashi, K; Ouchi, N; Shibata, R; Walsh, K, 2011)
"Obesity is a well established risk factor for developing an obstructive sleep apnea syndrome (OSAS)."( Braun, T; Dreher, A; Patscheider, M, 2012)
"Obesity is an epidemic that affects approximately 30% of the adult population in the United States."( Cave, MC; Frazier, TH; Hurt, RT; McClave, SA, 2011)
"As obesity is considered to be a modifiable risk factor, preconception counseling and creating awareness regarding health risks associated with over weight and obesity should be encouraged."( Banerjee, A; Biswas, SC; Dey, RP; Manda, S; Mandal, D; Rakshi, A, 2011)
"Obesity is associated with lower striatal dopamine D2 receptor availability, which may be related to disturbed regulation of food intake."( Booij, J; de Bruin, K; la Fleur, SE; van de Giessen, E; van den Brink, W, 2012)
"Obesity is an ongoing worldwide epidemic."( Campia, U; Cardillo, C; Tesauro, M, 2012)
"Obesity is a major cause for nonalcoholic fatty liver disease (NAFLD)."( Bischoff, SC; Haub, S; Hubert, A; Ladel, I; Ritze, Y; Saum, K; Spruss, A; Trautwein, C, 2011)
"Obesity is characterized by chronic inflammation of adipose tissue, which contributes to insulin resistance and diabetes."( Chait, A; Cheng, AM; Clowes, AW; Daum, G; Han, CY; Handa, P; Kim, F; Morgan-Stevenson, V; O'Brien, KD; Rizzo, NO; Schwartz, MW; Tateya, S, 2011)
"Obesity is characterized by the activation of an inflammatory process leading to an increase in proinflammatory cytokines and adipokines."( Bae, JH; Chung, IS; Ha, E; Jang, HS; Park, JH; Park, SH; Shin, DH; Song, DK; Yu, GI, 2011)
"Obesity is a chronic disease and a major global health challenge."( Lecoultre, V; Ravussin, E; Tam, CS, 2011)
"Clinically, obesity is a major risk factor for developing OSAS."( Agustí, AG; Barbé, F; Barceló, A; Capote, F; de la Peña, M; Durán-Cantolla, J; Esquinas, C; García-Río, F; Marin, JM; Mediano, O; Miro, A; Montserrat, JM; Piérola, J; Sánchez-de-la-Torre, M, 2012)
"Obesity is associated with increased cardiovascular disease."( Davì, G; Guagnano, MT; Liani, R; Santilli, F; Vazzana, N, 2012)
"Obesity is a significant risk factor, and animals with a higher than normal GHtR should preferably receive a lower dose."( DuFour, TA; Faig, AW; Graham, ML; Hering, BJ; Kittredge, JA; Munson, JW; Mutch, LA; Rieke, EF; Schuurman, HJ; Zolondek, EK, 2011)
"Obesity is a very common disorder directly linked with various diseases such as type-2 diabetes, hypertension and atherosclerosis."( Agarwal, CG; Awasthi, S; Mittal, B; Natu, SM; Prakash, J; Rajpal, N; Srivastava, N, 2011)
"Obesity is a health hazard which is closely associated with various complications including insulin resistance, hypertension, dyslipidemia, atherosclerosis, type 2 diabetes and cancer."( Lane, B; Sliva, D; Thyagarajan-Sahu, A, 2011)
"Obesity is an independent risk factor for mortality in patients infected with pandemic influenza A virus (H1N1)."( Lodise, TP; Pai, MP, 2011)
"Such form of obesity is mainly caused by the failure of elevated levels of the hormone leptin (LEP) to suppress feeding and mediate weight loss; the syndrome, caused by disruptions of signal transduction processes at the level of leptin receptors (LEPR), has been named as leptin resistance."( Gonzalez-Bulnes, A; Ovilo, C; Pallares, P, 2011)
"Obesity is a risk factor for asthma."( Cohen, RI; Dixon, AE; Griffes, LV; Johnson, SE; Ramdeo, R; Raymond, DM; Soloveichik, A; Suratt, BT, 2011)
"We conclude that obesity is associated with altered HPA activity in adolescent girls."( Berga, SL; Dorn, LD; Hillman, JB; Loucks, TL, 2012)
"Upper-body/visceral obesity is associated with abnormalities of free fatty acid (FFA) metabolism and greater risk of developing type 2 diabetes compared with lower-body obesity."( Christiansen, JS; Gormsen, LC; Nellemann, B; Nielsen, S; Sørensen, LP, 2012)
"Although obesity is associated with overactivation of the white adipose tissue (WAT) renin-angiotensin system (RAS), a causal link between the latter and systemic insulin resistance is not established."( Ailhaud, G; Kalupahana, NS; Massiera, F; Moustaid-Moussa, N; Quignard-Boulange, A; Voy, BH; Wasserman, DH, 2012)
"Obesity is a complex condition involving the dysregulation of several organ systems and molecular pathways, including adipose tissue, the pancreas, the gastrointestinal tract, and the CNS."( Block, RC; Geba, D; Golub, N; Mousa, SA; Williams, G, 2011)
"Obesity is an excess of body fat sufficient to result in impairment of health or body function."( Laflamme, DP, 2012)
"Obesity is a major public health issue worldwide."( Beaver, JD; Bloom, SR; De Silva, A; Dhillo, WS; Ghatei, MA; Long, CJ; Makwana, A; Matthews, PM; Newbould, RD; Rabiner, EA; Salem, V, 2011)
"Childhood obesity is a recent epidemic with a high magnitude in India."( Kumari, R; Midha, T; Nath, B; Pandey, U; Rao, YK, 2012)
"Obesity is recognized as the strongest risk factor for OSA."( , 2011)
"Furthermore, obesity is associated with a range of adverse health consequences."( Al-Nuaim, LA, 2011)
"Obesity is a state of chronic low-grade inflammation."( Hermansen, K; Herzig, KH; Holmer-Jensen, J; Karhu, T; Mortensen, LS; Pedersen, SB, 2011)
"Obesity is linked to increased risk of colon cancer, currently the third most common cancer."( Drew, JE, 2012)
"Obesity is a major and independent risk factor for cardiovascular disease and it is strongly associated with the development of dyslipidemia, insulin resistance and type 2 diabetes."( Plutzky, J; Quadro, L; Shabrova, EV; Singh, AP; Tarnopolsky, O; Vorsa, N, 2011)
"Obesity is a major health threat in the Western world because of its high incidence and prevalence, and its association with metabolic and cardiovascular disease as well as cancer."( Folli, F; Guardado Mendoza, R, 2011)
"Obesity is a highly prevalent condition associated with several diseases."( Almeida, WS; Araújo, RC; Barros, CC; Campbell, CS; Cunha, VN; Lima, LC; R Cunha, R; Simões, HG, 2011)
"Obesity is associated with systemic inflammation and is a risk factor for osteoarthritis (OA) development."( Gierman, LM; Huizinga, TW; Kleemann, R; Kloppenburg, M; Kooistra, T; Koudijs, A; Stojanovic-Susulic, V; Stoop, R; van der Ham, F; van Osch, GJ; Wielinga, PY; Zuurmond, AM, 2012)
"Obesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome."( Campos, RM; Carnier, J; Corgosinho, FC; Dâmaso, AR; de Mello, MT; de Piano, A; Oyama, LM; Sanches, PL; Silva, PL; Tock, L; Tufik, S, 2012)
"Obesity is associated with circulating levels of adiponectin and leptin and endometrial cancer risk."( Cai, H; Cai, Q; Chen, X; Cheng, J; Gao, YT; Long, JR; Shu, XO; Wen, W; Xiang, YB; Zheng, W, 2012)
"Obesity is an epidemic disease most commonly caused by a combination of increased energy intake and lack of physical activity."( Balbo, SL; Grassiolli, S; Marques da Silva, AC; Raineki, C; Sagae, SC, 2011)
"Obesity is associated with metabolic syndrome, a cluster of symptoms including diabetes, hyperlipidemia, hypertension and arteriosclerosis, which can cause serious health problems."( Hosoi, T, 2011)
"Obesity is an important public health problem worldwide and is a major risk factor for a number of chronic diseases such as type II diabetes, adverse cardiovascular events and metabolic syndrome-related features."( González-Muniesa, P; Martínez, JA; Portillo, MP; Urdampilleta, A, 2012)
"Obesity is characterized by increased cell death and inflammatory reactions in the adipose tissue."( Altintas, MM; Johnson, KB; McNamara, G; Mendez, AJ; Nayer, A; Nayer, B; Ortega, LM; Puig, A; Reiser, J; Rossetti, MA; Zagallo, P, 2011)
"Obesity is a major health problem in the world."( Han, JS; Tian, DR; Tso, P, 2011)
"Obesity is a major risk factor for coronary artery disease, but its impact on anesthetic-induced cardioprotective actions is unexplored."( Cui, WY; Lv, LY; Qu, G; Shi, XM; Song, T; Tian, ZY; Wang, QS; Xu, J, 2011)
"Obesity is one of the most influential but modifiable risk factors because it exerts an increased mechanical stress on the tibiofemoral cartilage."( Rai, MF; Sandell, LJ, 2011)
"Obesity is a risk factor for impaired glucose tolerance, diabetes and coronary artery disease, and most previous OC studies excluded these women; thus, we have limited information about carbohydrate and lipid metabolism in obese OC users."( Beasley, A; Estes, C; Guerrero, J; Westhoff, C, 2012)
"The prevalence of obesity is increasing in adult and child populations throughout the world."( Bajnok, L; Harangi, M; Józsa, L; Koncsos, P; Nagy, EV; Páll, D; Paragh, G; Seres, I, 2011)
"Obesity is a major public health problem leading to, among other things, reduced functional capacity."( Arena, R; Bagnato, VS; Borghi-Silva, A; Bueno, Pde G; Kurachi, C; Milan, JC; Paolillo, AR; Paolillo, FR; Parizotto, NA, 2012)
"Obesity is a significant public health problem reaching epidemic proportions worldwide."( Newbold, RR, 2011)
"Childhood obesity is associated with an increased risk of atherosclerosis, which can be mediated by an increase in angiogenesis and inflammation."( Aversano, M; Ciullo, M; Iafusco, M; Nutile, T; Ruggiero, D; Siervo, M; Sorice, R; Stephan, BC; Vetrano, F; Wells, JC, 2012)
"Obesity is reaching pandemic proportions in Western society."( Liao, JK; Wang, CY, 2012)
"Obesity is associated with elevated hepcidin concentrations and iron depletion suggesting that the exaggerated fat mass in obesity could contribute significantly to circulating hepcidin levels consequently altering iron homeostasis."( Dennis, AL; Frayn, KN; Nemeth, E; Pusatcioglu, C; Smith, SR; Thomson, J; Tussing-Humphreys, L; Westerman, M, 2011)
"The prevalence of obesity is increasing globally."( Balbo, SL; Bonfleur, ML; Brandelero, S; Nassar, CA; Nassar, PO; Ribeiro, RA; Vanzela, EC, 2012)
"Obesity is associated with chronic low-grade inflammation, which contributes to systemic metabolic irregularities and obesity-linked metabolic disorders."( Al-Naami, MY; Alfadda, AA; Chishti, MA; Elawad, R; Fatma, S; Jo, H; Lee, YS; Mendoza, CD, 2012)
"Obesity is an established risk and progression factor for postmenopausal breast cancer."( Dunlap, SM; Ford, NA; Hursting, SD; Nogueira, LM, 2012)
"Obesity is associated with an increased risk of developing type 2 diabetes and cardiovascular disease."( Sesti, G, 2011)
"Obesity is a serious chronic disease."( Allison, DB; Bowden, CH; Day, WW; Gadde, KM; Garvey, WT; Look, M; Peterson, CA; Ryan, DH; Schwiers, M, 2012)
"Obesity is a growing problem in the United States."( Fuentes, JM; Mullins, ME; Roe, JL, 2012)
"Obesity is associated with the dysregulations of a number of body components such as blood constituents, extracellular matrix, and hormones/growth factors axes, which could be utilized for early diagnosis."( Cleary, MP; Ray, A, 2012)
"The incidence of obesity is increasing rapidly all over the world and results in numerous health detriments, including disruptions in reproduction."( Bonfleur, ML; Franci, CR; Lubaczeuski, C; Menezes, EF; Sagae, SC; Sanvitto, GL; Vanzela, EC; Zacharias, P, 2012)
"Obesity is associated with low systemic inflammation and an accumulation of adipose tissue macrophages (ATMs) that are thought to modulate insulin resistance."( Caldwell, MT; Edgel, KA; Houston, BA; Leboeuf, RC; Mai, PO; McMillen, TS; Oram, JF; Pamir, N; Tang, C; Wei, H, 2012)
"Obesity is associated with changes in body composition including lean and fat mass."( Clifton, P; Jesudason, DR, 2012)
"Obesity is a condition that should be considered in HIV patients on cART."( Carvalho, D; Freitas, P; Madureira, AJ; Marques, R; Martinez, E; Matos, MJ; Medina, JL; Santos, AC; Sarmento, A, 2012)
"Obesity is frequently associated with breast cancer."( Ahn, SC; Bae, MK; Bae, SK; Bae, YH; Jang, HO; Kim, SR; Park, HJ; Wee, HJ; Yun, I, 2012)
"Obesity is a serious health problem implicated in many metabolic disorders (i."( Chung, JH; Do, HJ; Kim, OY; Lee, SM; Moon, J; Shin, MJ, 2012)
"Obesity is associated with elevated levels of inflammation and metabolic abnormalities which are linked to CVD."( Garg, ML; Munro, IA, 2012)
"Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis."( Ishii, M; Kito, T; Kondo, M; Murohara, T; Shibata, R; Suzuki, H; Yamamoto, T, 2012)
"Obesity is a growing problem in Europe and the United States."( Anderson, AE; Barg, A; Hintermann, B; Knupp, M, 2011)
"Male obesity is associated with reduced sperm motility and morphology and increased sperm DNA damage and oxidative stress; however, the reversibility of these phenotypes has never been studied."( Bakos, HW; Lane, M; Owens, JA; Palmer, NO; Setchell, BP, 2012)
"Obesity is associated with increased inducible nitric oxide synthase mRNA expression, with subsequent overproduction of nitric oxide and reactive nitrogen species leading to S-nitrosylation of proteins involved in insulin signalling cascade."( Haluzík, M; Tousková, V, 2011)
"Obesity is a multifactorial disease resulting from interactions between susceptibility genes, psychosocial, and environmental factors."( Chen, L; Guo, XR; Ji, CB; Qin, DN; Shi, CM; Xia, L; Zhang, CM; Zhu, GZ; Zhu, JG, 2012)
"Obesity is an important health problem in the world and related to many critical diseases, such as diabetes, cardiovascular disease, and metabolic syndrome."( Jeong, SU; Lee, SK, 2012)
"Dietary obesity is a major factor in the development of type 2 diabetes and is associated with intra-adipose tissue hypoxia and activation of hypoxia-inducible factor 1α (HIF1α)."( Danzer, C; Gasperikova, D; Krek, W; Krishnan, J; Kumpf, S; Mirtschink, P; Pedrazzini, T; Simka, T; Ukropcova, B; Ukropec, J; Walter, KM, 2012)
"Although obesity is highly prevalent, only a small percentage of obese Americans are on anti-obesity medication."( Cheung, BM; Leung, RY; Ong, KL; Samaranayake, NR, 2012)
"Obesity is associated with a low grade inflammation which contributes to the development of insulin resistance and diabetes."( Brignardello, J; Brunser, O; Diaz, E; Gotteland, M; Morales, P, 2011)
"Worldwide, obesity is the most prevalent form of malnutrition."( Krishna, V; Kumari, R; Midha, T; Nath, B; Pandey, U; Rao, YK, 2011)
"Obesity is characterized by an imbalance in the brain circuits promoting reward seeking and those governing cognitive control."( Hannukainen, JC; Hirvonen, J; Immonen, H; Lindroos, MM; Nummenmaa, L; Nuutila, P; Salminen, P, 2012)
"Obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases."( Claycombe, KJ; Kalupahana, NS; Moustaid-Moussa, N, 2011)
"Obesity is associated with larger tumors, shorter time to PSA failure, and higher Gleason scores."( Cavazos, DA; De Angel, RE; deGraffenried, LA; Hursting, SD; Price, RS, 2012)
"Obesity is a serious problem for modern medicine."( Góra, A; Równicka-Zubik, J; Sułkowska, A, 2011)
"Obesity is characterized as an increased BMI, which is associated with the increased risk of several common cancers, including colorectal, breast, endometrial, renal, esophageal, gallbladder, melanoma, multiple myeloma, leukemia, lymphoma and prostate cancer."( Khan, S; Shehzad, A; Sup Lee, Y, 2012)
"Obesity is associated with alterations in upper airway collapsibility during sleep."( Elsayed-Ahmed, AS; Harris, CC; Kirkness, JP; Pichard, L; Polotsky, M; Polotsky, V; Schneider, H; Schwartz, AR; Smith, PL, 2012)
"Obesity is considered as an independent risk factor for miscarriage, involved in oocyte and embryo quality, but also in endometrial receptivity."( Benammar, A; Cedrin-Durnerin, I; Dupont, C; Faure, C; Hercberg, S; Levy, R; Sermondade, N; Sifer, C, 2012)
"Obesity is an increasing problem in obstetric practice."( Hehir, MP; Morrison, JJ, 2012)
"Obesity is highly prevalent and affects, together with overweight, 74."( Baena-Díez, JM; Félix-Redondo, FJ; Fernández-Bergés, D; Grau, M; Tormo, MÁ, 2012)
"Overweight and obesity are often considered risk factors for cardiovascular events."( Akin, I; Bergmann, MW; Hochadel, M; Khattab, AA; Kuck, KH; Nienaber, CA; Richardt, G; Schneider, S; Senges, J; Tölg, R, 2012)
"Obesity is associated with hyperparathyroidism and increased bone mass and turnover, but their pathogeneses are unclear."( Acton, A; Cacucci, BM; Considine, RV; Grethen, E; Gupta, CE; Hill, KM; Jones, R; Peacock, M, 2012)
"Obesity is a contributory factor for the increased risk of gestational diabetes in this group of women and is estimated to affect 5-40% of pregnant women with PCOS."( Awwad, JT; Ghazeeri, GS; Nassar, AH; Younes, Z, 2012)
"Chronic obesity is associated with reduced levels of antioxidants, increased free oxygen radicals, and oxidative stress."( Gvozdjakova, A; Hlavata, A; Kucharska, J; Singh, RB; Tkacov, M, 2012)
"Obesity is a common problem and its health consequences depend on the phenotype of obesity."( Milewicz, A, 2012)
"The progression of obesity is accompanied by a chronic inflammatory process that involves both innate and acquired immunity."( Andoh, Y; Clingan, CS; Eshima, K; Fujii, S; Hirata, N; Ishimori, N; Iwabuchi, K; Nakayama, T; Ogura, H; Onoé, K; Satoh, M; Taniguchi, M; Tsutsui, H, 2012)
"Obesity is a major public health problem worldwide, and of late, epidemiological studies indicate a preponderance of cataracts under obesity conditions."( Giridharan, NV; Reddy, GB; Reddy, PY, 2012)
"Obesity is an important causative factor in morbidity, disability and premature death."( Gosden, J; Heal, DJ; Smith, SL, 2013)
"Adolescent obesity is increasingly viewed as a brain-related dysfunction, whereby reward-driven urges for pleasurable foods "hijack" response selection systems, such that behavioral control progressively shifts from impulsivity to compulsivity."( Campoy, C; Delgado-Rico, E; González-Jiménez, E; Río-Valle, JS; Verdejo-García, A, 2012)
"Obesity is generally linked to complications in lipid metabolism and oxidative stress."( Ansari, JA; Bhandari, U; Haque, SE; Pillai, KK, 2012)
"Obesity is often associated with disorders of iron homeostasis; however, the underlying mechanisms are not fully understood."( Ebenbichler, CF; Kaser, S; Moser, P; Murphy, AT; Nairz, M; Ress, C; Schroll, A; Sonnweber, T; Theurl, I; Weiss, G; Witcher, DR; Wroblewski, V, 2012)
"Obesity is a major health problem showing increased incidence in developed and developing countries."( Kikuchi, S; Miyashita, M; Oshiro, E; Sadzuka, Y; Sugiyama, I; Ueda, T; Yamada, H; Yano, A, 2012)
"Obesity is a health hazard that is associated with a number of diseases and metabolic abnormalities, such as type-2 diabetes, hypertension, dyslipidemia, and coronary heart disease."( Cho, JH; Kim, CH; Kim, GS; Kim, MK; Ko, YG; Koh, PO; Min, W; Park, HJ; Won, CK; Woo, JH, 2012)
"Obesity is an independent risk factor for chronic disease."( Breslin, WL; Carpenter, KC; Davidson, TR; Foreyt, JP; Johnston, CA; McFarlin, BK; Moreno, JP; Strohacker, K, 2012)
"Obesity is closely associated with increased incidence of cardiovascular diseases, cancer, insulin resistance, and immune dysfunction, and thus obesity-mitigation strategies should take into account these secondary pathologies in addition to promoting weight loss."( Heuberger, AL; Kester, AC; Reddivari, L; Vanamala, J, 2012)
"Obesity is a serious disease that is associated with an increased risk of diabetes, hypertension, heart disease, stroke, and cancer, among other diseases."( Braverman, ER; Shah, NR, 2012)
"Obesity is a risk factor for hypertension and other vascular disease."( Grayson, TH; Howitt, L; Morris, MJ; Murphy, TV; Sandow, SL, 2012)
"Asthma and obesity are growing epidemics in the world."( Antunes, E; Calixto, MC; Lintomen, L; Schenka, A, 2012)
"Obesity is highly co-morbid with anxiety and/or depression in children, conditions that may further worsen the metabolic and cardiovascular risks for obese individuals."( Bastaki, D; Chouliaras, G; Chrousos, GP; Kanaka-Gantenbein, C; Laios, E; Papanikolaou, K; Pervanidou, P, 2013)
"Obesity is associated with an increased incidence of left ventricular hypertrophy, diastolic dysfunction, heart failure, and premature cardiac aging."( Boening, A; Niemann, B; Pan, R; Rohrbach, S; Silber, RE; Teschner, M, 2013)
"Obesity is unlikely to affect ovarian reserve in the premenopausal age group."( Atakul, N; Erel, CT; Imamoğlu, M; Küçük, M; Sahmay, S; Seyisoğlu, H; Usta, T, 2012)
"Obesity is linked to insulin resistance (IR), which can lead to type 2 diabetes mellitus."( Arilla-Codoñer, A; Ballester-Asensio, E; Codoñer-Franch, P; Fernández-Ferri, M; Navarro-Ruiz, A; Valls-Bellés, V, 2012)
"Obesity is a risk factor for hormone receptor-positive breast cancer in postmenopausal women."( Dannenberg, AJ; Du, B; Giri, D; Hudis, CA; Kopelovich, L; Morris, PG; Morrow, M; Subbaramaiah, K; Zhou, XK, 2012)
"Obesity is associated with insulin resistance, chronic low-grade inflammation, and atherosclerosis."( Chait, A; Ding, Y; Goodspeed, L; Han, C; Kim, J; Montes, VN; O'Brien, KD; Subramanian, S; Teresa, AS; Wang, S, 2012)
"Obesity is associated with high glucagon responses, and liver-specific inhibition of NIK led to lower glucagon responses and HGP and protected against hyperglycemia and glucose intolerance in obese mice."( Chen, Z; Cho, KW; Jiang, L; Ren, D; Rui, L; Sasaki, Y; Shen, H; Sheng, L; Zhou, Y, 2012)
"Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and is often associated with hypertension."( Allorge, D; Bessede, A; Caiazzo, R; Froguel, P; Guillemin, GJ; Hennart, B; Leloire, A; Pattou, F; Pigeyre, M; Poulain-Godefroy, O; Raverdy, V; Soichot, M; Taront, S; Wolowczuk, I, 2012)
"Obesity is a risk factor for breast and ovarian cancer; the mechanisms of action are not completely understood."( Garmo, H; Hammar, N; Holmberg, L; Jungner, I; Lambe, M; Melvin, JC; Seth, D; Van Hemelrijck, M; Walldius, G; Wigertz, A, 2012)
"Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and marginally elevated expression of IL-6, but PCOS does not appear to have an independent effect on the adipose expression of leptin, adiponectin, and IL-6 or the circulating adipocytokines."( Christiansen, M; Hedley, PL; Madsbad, S; Nilas, L; Pedersen, SB; Svendsen, PF, 2012)
"Childhood obesity is rapidly increasing in prevalence."( Foster, GD; Gunawardana, J; Komaroff, E; McCoy, TA; Nguyen, T; Rao, AK; Singh, A; Vander Veur, S, 2012)
"Obesity is associated with an increased risk of having a pregnancy affected by a neural tube defect (NTD)."( Bailey, LB; Berry, RJ; Hamner, HC; Pfeiffer, CM; Tinker, SC, 2012)
"Obesity is a serious social problem, one of the most important health issues of the modern world, especially in industrialized countries."( Adamska, E; Jastrzebska, M; Ostrowska, L; Stefańska, E; Waszczeniuk, M; Wujek, A, 2012)
"Obesity is an important public health problem worldwide."( Li, Q; Qiao, L; Zhang, J; Zhou, Y, 2012)
"Obesity is a well-established risk factor for incisional hernia development."( Bodnar, M; Dabrowiecki, S; Marszałek, A; Szczesny, W; Szmytkowski, J, 2013)
"Diabetes and obesity are more prevalent amongst psoriasis patients as is disturbance of the innate immune system."( Ahern, T; Corrigan, M; Hogan, A; Kirby, B; O'Shea, D; Sweeney, C; Tobin, AM, 2013)
"Obesity is associated with risk factors for heart disease and diabetes."( Baker, J; Baker, JS; Brophy, S; Knox, G; Rees, A; Thomas, NE, 2012)
"Obesity is a significant and independent risk factor for cardiovascular disease, and assessing ischaemia in obese patients is clinically important but sometimes difficult because of imaging artefacts."( Bottai, M; Filidei, E; Genovesi, D; Gimelli, A; Giorgetti, A; Marzullo, P, 2012)
"Obesity is a risk factor for cancer, including hepatocellular carcinoma."( Adiels, M; Baroni, MG; Borén, J; Burza, MA; Carlsson, LM; Ginanni Corradini, S; Jacobson, P; Maglio, C; Mancina, RM; Montalcini, T; Pirazzi, C; Romeo, S; Sjöholm, K; Sjöström, L; Svensson, PA, 2012)
"Obesity is now recognised as one of the most important risk factors for heart disease."( Karbowska, J; Kochan, Z, 2012)
"Obesity is often associated with chronic inflammatory state which contributes to the development of insulin resistance (IR) and type 2 diabetes mellitus (T2DM)."( El-Moselhy, MA; Heeba, GH; Mourad, AA; Taye, A, 2013)
"OBJECTIVES."( Kartini, A; Norlelawati, AT; Norsidah, K; Ramli, M; Tariq, AR; Wan Azizi, WS, 2012)
"Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D)."( Adiels, M; Borén, J; Burch, L; Burza, MA; Carlsson, LM; Colhoun, H; Dillon, JF; Doney, AS; Donnelly, LA; Frayling, T; Hattersley, AT; Jacobson, P; Maglio, C; McCarthy, M; Morris, AD; Palmer, CN; Pearson, ER; Peltonen, M; Pirazzi, C; Romeo, S; Sjöström, L; Svensson, PA, 2012)
"Obesity is an energy balance problem caused by overeating."( Bahar, B; Cevik, C; Demirtas, C; Güçel, F; Mit, S, 2012)
"concluded that obesity is an independent predictor of inadequate bowel preparation at colonoscopy."( Fok, KC; Levy, RL; Teoh, WC; Turner, IB, 2012)
"Obesity is associated with increased prevalence and severity of asthma."( Church, TD; Francisco, D; Hollingsworth, JW; Howell, DL; Ingram, JL; Jung, SH; Kraft, M; Lugogo, NL; Potts-Kant, EN; Que, LG; Wang, Y, 2012)
"The development of obesity is determined by lifestyle and genetic mechanisms."( Baturin, AK; Makurina, ON; Pogozheva, AV; Sorokina, EIu; Tutel'ian, VA, 2012)
"Childhood obesity is becoming a worldwide epidemic and its metabolic and cardiovascular complications may already be evident at a young age."( Baran, M; Borysewicz-Sańczyk, H; Bossowski, A; Hryniewicz, A; Porowski, T; Zasim, A, 2012)
"The prevalence of obesity is increasing globally, and obesity is a major risk factor for metabolic diseases such as type 2 diabetes."( Esposito, D; Kizelsztein, P; Komarnytsky, S; Raskin, I, 2012)
"Obesity is a serious and rapidly growing health problem worldwide."( Ferrufino, CP; Klingman, D; Lee, WC; Oleske, DM; Tyczynski, JE, 2012)
"Obesity is a growing problem throughout Europe, where the rate has more than doubled over the past 20 years."( Bunting, BP; Carr, E; Hodge, S; Stewart-Knox, BJ; Strain, JJ, 2012)
"Type 2 diabetes and obesity are associated with increased risk of site-specific cancers."( Beguinot, F; Canta, L; D'Esposito, V; Formisano, P; Hammarstedt, A; Liguoro, D; Miele, C; Molea, G; Passaretti, F; Smith, U; Terracciano, D, 2012)
"Obesity is a known risk factor for many types of cancers and a number of endocrine factors, including adipokines and steroid hormones, are regulated by and regulate AMPK."( Brown, KA; Samarajeewa, NU; Simpson, ER, 2013)
"Obesity is a chronic disease defined by an excess amount of adipose tissue and presents a low-grade inflammatory state, increasing cardiovascular risk."( Campos, RM; Caranti, DA; Carnier, J; Corgosinho, FC; da Silva, PL; Dâmaso, AR; de Mello, MT; de Piano, A; Masquio, DC; Oller do Nascimento, CM; Oyama, LM; Sanches, PL; Tock, L; Tufik, S, 2013)
"Obesity is among the leading causes of disease and death."( Goldstone, AP; Hackenberg, T; Jackson, RN; Jackson, SN; le Roux, CW; Miras, AD; Olbers, T; Spector, AC, 2012)
"Obesity is an established independent risk factor for VTE."( Clemens, A; Dahl, OE; Eriksson, BI; Feuring, M; Friedman, RJ; Hantel, S; Huo, M; Noack, H, 2012)
"Obesity is also associated with increased activity of the endocannabinoid system, and CB(1) receptor (CB(1)R) inverse agonists reduce body weight and the associated metabolic complications, although adverse neuropsychiatric effects halted their therapeutic development."( Chedester, L; Cheng, K; Chorvat, RJ; Cinar, R; Deschamps, JR; Godlewski, G; Innis, RB; Jourdan, T; Kunos, G; Liow, JS; Liu, J; McElroy, JF; Mukhopadhyay, B; Rice, KC; Szanda, G; Tam, J; Wesley, D, 2012)
"Obesity is a risk factor for injury, and the growing prevalence may be associated with increases in the future incidence and cost of injuries."( Cavuoto, LA; Nussbaum, MA, 2013)
"Obesity is associated with many diseases, one of the most common being obstructive sleep apnea (OSA), which in turn leads to blood gas disturbances, including intermittent hypoxia (IH)."( Haddad, GG; Heinrichsen, ET, 2012)
"Obesity is increasing worldwide and it is accompanied by major health effects."( Geurts van Kessel, WM; Jak, LG; Korndewal, MJ; Rövekamp, MH; Uiterwaal, CS; van der Ent, CK, 2012)
"Obesity is an important risk factor for atrial fibrillation (AF)."( Chen, JH; Chen, SA; Chen, YC; Chen, YJ; Lin, YK, 2012)
"Obesity is a rapidly growing epidemic that now affects approximately 30% of the adult population in the United States."( Hurt, RT; Wilson, T, 2012)
"Obesity is one of the major challenges to human health worldwide; however, there are currently no effective pharmacological interventions for obesity."( Bloom, SR; Jayasena, CN; Suzuki, K, 2012)
"Obesity is associated with risk of colorectal adenoma and colorectal cancer."( Gerner, EW; Lin, BS; Madson, N; McLaren, CE; Meyskens, FL; Zell, JA, 2012)
"Obesity is associated with a state of chronic low-grade inflammation."( Aguilera, CM; Bueno, G; Cañete, R; Gil, A; Gil-Campos, M; Leis, R; Martínez-Jiménez, MD; Moreno, LA; Olza, J; Tojo, R; Valle, M, 2012)
"Obesity is a consequence of a complex interplay between the host genome and the prevalent obesogenic factors among the modern communities."( Chavan, SG; Dhotre, DP; Gangawani, J; Jain, DS; Lanjekar, VB; Patil, DP; Patole, MS; Ranade, DR; Shah, PS; Shah, S; Shouche, YS; Sultan, A; Todkar, JS, 2012)
"Canine obesity is associated with the development of insulin resistance, dyslipidaemia, and mild hypertension, but the authors are not aware of any existing studies examining the existence or prevalence of MS in obese dogs."( Biourge, V; Ceron, JJ; Cuthbertson, DJ; German, AJ; Holden, SL; Morris, PJ; Tvarijonaviciute, A, 2012)
"Obesity is a disease that has become a serious public health issue worldwide, and chronic stressors, which are a problem for modern society, cause neuroendocrine changes with alterations in food intake."( Caumo, W; Cioato, SG; Macedo, IC; Medeiros, LF; Oliveira, C; Oliveira, CM; Rozisky, JR; Santos, VS; Scarabelot, VL; Silva, FR; Souza, A; Torres, IL, 2012)
"Obesity is recognized as a social problem, associated with serious health risks and increased mortality."( Rani, N; Sharma, SK; Vasudeva, N, 2012)
"Obesity is a risk factor for postmenopausal disease, and adult weight gain should be avoided to reduce risk."( Thomson, CA, 2012)
"Obesity is rising at an alarming rate globally."( Anastasovska, J; Arora, T; Bell, JD; Deaville, ER; Frost, G; Gibson, GR; Holmes, E; Loo, RL; Sharma, RK; Sleeth, ML; Swann, JR; Thomas, EL; Tuohy, KM, 2012)
"Obesity is a global epidemic associated with multiple severe diseases."( Frimurer, TM; Högberg, T; Sasmal, PK, 2012)
"The neurobiology of obesity is poorly understood."( Bechtell, JL; Cornier, MA; Eichman, LC; Smucny, J; Thomas, EA; Tregellas, JR, 2012)
"Obesity is a risk factor for numerous metabolic disorders."( Choi, KM; Hong, JT; Kim, SY; Lee, JH; Lee, MK; Lee, S; Lee, YM; Lee, YS; Shin, DM; Yoo, HS; Yoo, KS; Yun, YP, 2013)
"Pregnancy and obesity are frequently associated with diminished insulin sensitivity, which is normally compensated for by an expansion of the functional β cell mass that prevents chronic hyperglycemia and development of diabetes mellitus."( Abderrahmani, A; Bosco, D; Cornu, M; Jacovetti, C; Jonas, JC; Laybutt, R; Meugnier, E; Parnaud, G; Peyot, ML; Prentki, M; Regazzi, R; Rome, S; Thorens, B, 2012)
"Obesity is associated with elevated levels of IL-6."( Castellanos, KJ; Fantuzzi, G; Pini, M; Rhodes, DH, 2013)
"Obesity is associated with the increased incidence of colon cancer."( Chen, J; Iverson, D, 2012)
"Obesity is associated with several hormonal derangements as well as dysregulation of insulin/insulin-like growth factor activity, which collectively contribute to hyperplasia and carcinogenesis in the endometrium."( Carlson, MJ; Leslie, KK; Thiel, KW; Yang, S, 2012)
"Obesity is a prognostic factor for severity in acute pancreatitis in humans."( Aparisi, L; Arduini, A; Asensi, M; Escobar, J; Pereda, J; Pérez, S; Sabater, L; Sastre, J; Serviddio, G, 2012)
"Obesity is associated with various health afflictions, including ocular complications such as diabetic retinopathy, high intraocular pressure, cataracts, and macular degeneration."( Ananthathmakula, P; Ayyagari, R; Ayyalasomayajula, V; Nappanveettil, G; Reddy, GB; Tiruvalluru, M, 2013)
"Obesity is a major risk factor for hypertension."( Ali, MI; Belin de Chantemèle, EJ; Fulton, DJ; Mintz, JD; Rainey, WE; Stepp, DW; Tremblay, ML, 2012)
"Obesity is a risk factor for metabolic diseases."( Baranowski, M; Błachnio-Zabielska, AU; Dmitruk, I; Górski, J; Hirnle, T; Lewczuk, A; Zabielski, P, 2012)
"Obesity is a risk factor for the development of insulin resistance and is one of the most important contributors to the pathogenesis of type 2 diabetes, which acts mainly through the secretion of adipokines such as TNF-α that may influence insulin sensitivity."( Cohan, RA; Ghorbani, M; Ghorbani, P; Gigloo, SH; Inanlou, DN; Shafiee Ardestani, M, 2012)
"Obesity is associated with dysmetabolism and endangers the healthy equilibrium of sexual hormone-production and regular menstrual cycles in women, which are the prerequisites not only for reproductive capacity but also for somatic health."( Suba, Z, 2013)
"Obesity is associated with atrial fibrillation (AF); however, the mechanisms by which it induces AF are unknown."( Abed, HS; Abhayaratna, WP; Alasady, M; Brooks, AG; Kalman, JM; Kelly, DJ; Kuklik, P; Lau, DH; Mahajan, R; Nelson, AJ; Royce, SG; Samuel, CS; Sanders, P; Wittert, GA; Worthley, SG; Zhang, Y, 2013)
"Obesity is associated with atrial electrostructural remodeling."( Abed, HS; Abhayaratna, WP; Alasady, M; Brooks, AG; Kalman, JM; Kelly, DJ; Kuklik, P; Lau, DH; Mahajan, R; Nelson, AJ; Royce, SG; Samuel, CS; Sanders, P; Wittert, GA; Worthley, SG; Zhang, Y, 2013)
"Obesity is linked to a wide variety of cardiac changes, from subclinical diastolic dysfunction to end-stage systolic heart failure."( Clarke, K; Cox, P; Neubauer, S; Rider, OJ; Tyler, D, 2013)
"Obesity is a global problem with often strong neurobiological underpinnings."( Adan, RA; Meye, FJ; Ramakers, GM; Trezza, V; Vanderschuren, LJ, 2013)
"Obesity is a risk factor associated with several pain syndromes."( DeVilbiss, JL; Luu, AK; Recober, A; Rossi, HL, 2013)
"Numerous models of obesity are characterized by increased central nervous system (CNS) neuropeptide Y (NPY) tone that contributes to excess food intake and obesity."( Beck-Sickinger, AG; Niswender, KD; Printz, RL; Rojas, JM; Saadat, S; Stafford, JM, 2012)
"Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health."( Amalraj, V; Ganeshkumar, P; Gopalakrishnan, S; Prakash, MV, 2012)
"Obesity is associated with increased expression of certain inflammatory cytokines in the adipose tissue."( Gelato, M; McNurlan, M; Mileva, I; Mynarcik, D; Pearl, M; Zakhaleva, J; Zemlyak, A, 2012)
"Obesity is for many scholars the most important starting status that gives rise to Metabolic Syndrome (MS) and Type 2 Diabetes (T2D)."( Abd-El-Fatah-Khalil, S; Algora, M; Areces, C; Arnaiz-Villena, A; Arribas, I; Coca, C; Enríquez-de-Salamanca, M; Fernández-Honrado, M; Rey, D, 2013)
"Obesity is an established risk factor for colorectal cancer."( Fujii, G; Komiya, M; Mutoh, M; Nakano, K; Takahashi, M; Takasu, S; Teraoka, N; Ueno, T; Wakabayashi, K; Yamamoto, M; Yanaka, A, 2012)
"The prevalence of obesity is rising worldwide, with the U."( Carter, R; Mouralidarane, A; Oben, J; Ray, S; Soeda, J, 2012)
"Obesity is a health problem that has become a major focus of attention in recent years."( Ariza, M; García-García, I; Garolera, M; Junqué, C; Jurado, MA; Marqués-Iturria, I; Narberhaus, A; Pueyo, R; Sala-Llonch, R; Segura, B; Sender-Palacios, MJ; Vernet-Vernet, M, 2013)
"Obesity is a serious health problem because of its co-morbidities."( Lemmens, SG; Westerterp, KR; Westerterp-Plantenga, MS, 2012)
"In Japan, obesity is defined by a BMI of 25 kg/m² or over; 28."( Inukai, Y; Iwase, S; Kanikowska, D; Nishimura, N; Sato, M; Shimizu, Y; Sugenoya, J, 2013)
"Childhood obesity is associated with an increased risk for atherosclerosis mediated by the pathogenetic mechanisms that lead to the development of the Metabolic Syndrome (MetS)."( Akalestos, A; Apostolakou, F; Bastaki, D; Chrousos, G; Papassotiriou, I; Pervanidou, P, 2013)
"Dietary obesity is usually characterized by leptin resistance and abnormal lipid metabolism."( Hou, SZ; Huang, S; Lai, XP; Li, YS; Liu, JQ; Qiu, SQ; Song, HP; Xie, FY; Zhou, CJ, 2013)
"Obesity is often associated with an abnormal lipoprotein profile, which may be partly negated by pioglitazone intervention, as this can influence the composition and oxidation characteristics of low-density lipoprotein (LDL)."( Hull, SS; McCance, DR; McEneny, J; McGinty, A; McPherson, PA; Young, IS, 2013)
"Childhood obesity is increasingly associated with type 2 diabetes (T2D)."( Amin, R; Barrett, T; Clayton, P; Dimitri, P; Hall, C; Ivison, F; Kendall, D; Kibirige, M; Mathew, V; Matyka, K; McGovern, A; Stirling, H; Tetlow, L; Vail, A; Wales, J; Wright, N, 2013)
"Obesity is also a feature of this syndrome and contributes to associated metabolic abnormalities."( Bates, GW; Propst, AM, 2012)
"Obesity is a predictor of diabetes and cardiovascular disease."( Kinter, M; Plafker, SM; Rindler, PM; Szweda, LI, 2013)
"Obesity is a well-known risk factor for this condition, however chronic intake of opioids as a risk factor for central sleep apnoea is under-recognised."( Fahim, A; Johnson, AO, 2012)
"While obesity is a common and increasing problem in childhood, Cushing's disease is rare."( Bisschop, PH; Reneman, L; van Furth, W; van Santen, HM; van Trotsenburg, AS; van Wezel, EM, 2012)
"Overweight and obesity are the epidemics of the 21st century in developed countries."( Aguilera, CM; Gil, A; Gil-Campos, M; Martínez-Augustin, O; Sánchez de Medina, F, 2012)
"Obesity is a growing problem in industrial nations."( Keel, M; Mica, L; Trentz, O; Vomela, J, 2014)
"Childhood obesity is growing at an alarming rate."( Cortes-Arenas, E; Flores-Dorantes, MT; Mendoza-Lorenzo, P; Ostrosky-Wegman, P; Pánico, P; Salazar, AM; Saucedo, R; Sordo, M; Taja-Chayeb, L, 2013)
"Obesity is a chronic disease associated with oxidative stress."( Biscaro, F; Dadalt, C; de Freitas, MB; Fagundes, RL; Jordão Júnior, AA; Moreira, EA; Pedrosa, RC; Vannucchi, H; Wilhelm-Filho, D, 2013)
"Obesity is associated with an increased risk of development of numerous diseases including type 2 diabetes, hypertension, hyperlipidemia, and cardiovascular disease."( Hsieh, YH; Wang, SY, 2013)
"Human obesity is characterized by high levels of leptin, and it has been suggested that obese patients may be leptin resistant."( Aller, R; Conde, R; de Luis, DA; Eiros Bouza, J; Izaola, O, 2013)
"Although obesity is well known to cause diastolic dysfunction a link to impaired cardiac energetics has only recently been established."( Byrne, J; Clarke, K; Francis, JM; Neubauer, S; Rider, OJ; Tyler, D, 2013)
"Obesity is associated with increased systemic and airway oxidative stress, which may result from a combination of adipokine imbalance and antioxidant defenses reduction."( Dai, FJ; Hsu, WH; Huang, JJ; Wu, SC, 2013)
"Obesity is highly prevalent among adults with acquired, structural hypothalamic damage."( Cuthbertson, DJ; Daousi, C; Das, KS; Gilkes, C; Javadpour, M; MacFarlane, IA; Steele, CA; Wilding, JP, 2013)
"Obesity is a major worldwide health problem."( da Silva, AA; do Carmo, JM; Hall, JE, 2013)
"Obesity is characterized by a low grade chronic inflammation state."( Consoli, A; D'Adamo, M; Di Pietro, N; Formoso, G; Guagnano, MT; Taraborrelli, M; Tartaro, A, 2012)
"Because maternal obesity is associated with both delivery disorders and elevated circulating leptin levels, this study aimed to assess the ability of leptin to interfere with lipopolysaccharide (LPS)-induced myometrial ECM remodeling."( Bardou, M; Barrichon, M; Dumas, M; Garrido, C; Goirand, F; Hadi, T; Le Ray, I; Lirussi, F; Mourtialon, P; Sagot, P; Wendremaire, M, 2013)
"Obesity is reaching epidemic proportions all over the world yet it lacks adequate treatment."( Gupta, P; Gupta, YK; Mehla, J, 2012)
"Obesity is now a worldwide health problem and is generally recognized as an inflammatory disease."( Deng, S; Guo, S; Hong, S; Jiang, D; Li, H; She, Z; Wang, T; Wang, XA; Yang, L; Zhang, R; Zhang, S; Zhang, XD; Zhong, J, 2013)
"Obesity is associated with a high circulating leptin level and severe 2009 pandemic influenza A virus subtype H1N1 (A[H1N1]pdm09) infection."( Chan, CC; Hung, IF; Lam, KS; Lau, CC; Li, C; Poon, VK; To, KK; Xu, A; Yuen, KY; Zhang, AJ; Zheng, BJ, 2013)
"Obesity is now growing at an alarming rate reaching epidemic proportions worldwide thus increasing morbidity and mortality rates for chronic disease."( Businaro, R; Canitano, N; Ippoliti, F, 2013)
"Obesity is a disease involving body weight gain."( Elnour, WA; Mahmoud, RH, 2013)
"Maternal obesity is associated with increased risks of pregnancy complications."( Ferraro, ZM; Gruslin, A; Tessier, DR, 2013)
"Across species obesity is associated with several disorders but in companion animals little information is available on the impact of chronic obesity on immune competence."( Biourge, V; Buyse, J; Cox, E; Duchateau, L; Hesta, M; Janssens, GP; Nguyen, P; Rochus, K; Scharek-Tedin, L; Van de Velde, H; Zentek, J, 2013)
"Obesity is an important risk factor for intervertebral disc degeneration and leptin is a biomarker of obesity."( Li, Z; Liang, J; Liu, J; Qiu, G; Shen, J; Wu, WK; Yu, X, 2013)
"Obesity is associated with a prothrombotic state resulting from increased thrombin generation, platelet hyper-reactivity, and decreased fibrinolysis."( Gremmel, T; Kopp, CW; Koppensteiner, R; Panzer, S; Seidinger, D; Steiner, S, 2013)
"Obesity is characterized by decreased insulin-stimulated glucose uptake in muscle and shift from glucose to lipid oxidation, the so-called metabolic inflexibility."( De Gaetano, A; Iesari, S; le Roux, CW; Manco, M; Mingrone, G; Nanni, G, 2013)
"Obesity is usually associated with hyperinsulinemia."( Blagosklonny, MV; Demidenko, ZN; Leontieva, OV; Paszkiewicz, G, 2013)
"Obesity is associated with increased adipose tissue macrophage (ATM) infiltration, and rodent studies suggest that inflammatory factors produced by ATMs contribute to insulin resistance and type 2 diabetes."( Carey, M; Carrasco, E; Chen, J; Hawkins, M; Kehlenbrink, S; Kishore, P; Koppaka, S; Lee, DE; Lee, H; Li, W; Sanchez, E; Zhang, K, 2013)
"Obesity is an established risk factor for type 2 diabetes (T2D) and they are metabolically related through the mechanism of insulin resistance."( Ben-Shlomo, Y; Bowen, L; Chandak, GR; Dudbridge, F; Ebrahim, S; Evans, D; Gupta, V; Janipalli, CS; Kinra, S; Kranthi Kumar, MV; Mani, KR; Prabhakaran, D; Rafiq, S; Reddy, KS; Sandeep, MN; Smith, GD; Sovio, U; Sullivan, R; Taylor, A; Timpson, N; Vinay, DG, 2013)
"Obesity is known to be an important risk factor for many types of cancer, such as breast, prostate, liver and endometrial cancer."( Breslin, M; Chang, YC; Chen, C; Lan, MS, 2013)
"Obesity is associated with increased breast tumor aggressiveness and decreased response to multiple modalities of therapy in postmenopausal women."( Blando, JM; Cui, Z; De Angel, RE; Dunlap, SM; Hogan, MG; Hursting, SD; Lansakara-P, DS; Sandoval, MA, 2013)
"Maternal obesity is associated with altered placental vascular function which may adversely affect placental oxygen and nutrient transport, placing the fetus at risk."( Cowley, EJ; Greenwood, SL; Hayward, CE; Higgins, L; Mills, TA; Sibley, CP; Wareing, M, 2013)
"Obesity is associated with a great diversity of diseases including non-alcoholic fatty liver disease."( Chang, HC; Huang, CN; Peng, CH; Wang, CJ; Wang, SJ; Yeh, DM, 2013)
"Obesity is the most critical factor in the pathology of metabolic syndrome (MetS), and is associated with an increased risk of depression."( Katsuura, G; Nakao, K; Ochi, Y; Yamada-Goto, N, 2012)
"Obesity is often associated with left ventricular (LV) diastolic dysfunction (DD)."( Bastien, M; Bergeron, S; Bertrand, F; Biertho, L; Lescelleur, O; Martin, J; Pibarot, P; Poirier, P; Simard, S, 2013)
"Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially hepatocellular carcinoma (HCC)."( Duan, XF; Li, Q; Tang, P; Yu, ZT, 2013)
"Obesity is widely acknowledged as a critical risk factor for metabolic complications."( Calanna, S; Di Pino, A; Maria Rabuazzo, A; Maria Zagami, R; Piro, S; Purrello, F; Urbano, F, 2013)
"Obesity is one of the highest preventable causes of morbidity and mortality in the developed world [1]."( Le Foll, B; Le Strat, Y; Sharkey, KA; Trigo, JM, 2013)
"Overweight and obesity are risk factors for type 2 diabetes, and they also influence the overall prognosis."( Eriksson, J; Laine, M, 2013)
"Obesity is likely to have a larger effect on women with arthritis than men."( Chen, Y; De Angelis, G, 2013)
"Pediatric obesity is associated with endothelial dysfunction and hypoadiponectinemia, but the relationship between these two conditions remains to be fully clarified."( Altomare, M; Bartolomeo, N; Carratù, MR; De Benedictis, L; Faienza, MF; Giordano, P; Leo, V; Montagnani, M; Nacci, C, 2013)
"Obesity is a known risk factor for venous and arterial thrombosis but the mechanisms are still unclear."( Antovic, JP; Bremme, K; Holmström, M; Lärfars, G; Rosing, J; Sonnevi, K; Tchaikovski, SN, 2013)
"Obesity is a complex metabolic disorder that often manifests with a strong genetic component in humans."( Hasan, G; Kumar, S; Metya, SK; Sadaf, S; Schwudke, D; Subramanian, M, 2013)
"Type 2 diabetes and obesity are intimately linked; reduction of bodyweight improves glycemic control, mortality and morbidity."( Bloom, S; Kenkre, J; Tan, T, 2013)
"Obesity is now considered as a major risk factor for the development of fatty liver diseases, cardiovascular diseases, and atherosclerosis."( Choi, IH; Jeong, HJ; Kim, HM; Lee, EH; Moon, PD; Rim, HK, 2013)
"Obesity is a low-grade chronic inflammatory condition and obesity-related cytokines such as interleukin-6, adiponectin, leptin, and tumor necrosis factor-α may play important roles in the development of nonalcoholic fatty liver disease (NAFLD)."( Basaranoglu, G; Basaranoglu, M; Sabuncu, T; Sentürk, H, 2013)
"Obesity is associated with increased levels of angiotensin-II (Ang-II), which activates angiotensin type 1a receptors (AT1a) to influence cardiovascular function and energy homeostasis."( de Kloet, AD; Frazier, CJ; Herman, JP; Hiller, H; Krause, EG; Pati, D; Seeley, RJ; Sumners, C; Wang, L; Woods, SC, 2013)
"Obesity is a significant contributing factor to endometrial cancer risk."( Broaddus, RR; Burzawa, JK; Celestino, J; Huang, M; Iglesias, D; Lu, KH; McCampbell, AS; Meyer, LA; Schmandt, R; Urbauer, DL; Yates, MS; Zhang, Q, 2013)
"Obesity is a key factor in the development of the metabolic syndrome (MetS), which is associated with increased cardiometabolic risk."( Blaak, EE; Defoort, C; Drevon, CA; Gjelstad, IM; Hall, W; Karlstrom, B; Kiec-Klimczak, M; Lopez-Miranda, J; Lovegrove, JA; Malczewska-Malec, M; Perez-Martinez, P; Phillips, CM; Risérus, U; Roche, HM; Tierney, AC, 2013)
"Obesity is associated with lower serum concentrations of 25-hydroxyvitamin D (25OHD) and higher intact PTH."( Durazo-Arvizu, R; Lee, EJ; Schneider, SH; Shapses, SA; Sukumar, D, 2013)
"Obesity is associated with a chronic low-grade inflammation characterized by increased levels of proinflammatory cytokines that are implicated in disrupted metabolic homeostasis."( Bohl, JA; Grinchuk, V; Notari, L; Qin, B; Sesaki, H; Shea-Donohue, T; Smith, A; Sun, R; Urban, JF; Yang, Z; Zhang, Z; Zhao, A, 2013)
"Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration."( Ahlin, S; Andersson-Assarsson, JC; Bergman, RN; Borén, J; Carlsson, LM; Froguel, P; Jacobson, P; Jansson, PA; Olsson, B; Poitou, C; Prifti, E; Sjöholm, K; Sjöström, L; Svensson, PA; Tordjman, J; Walley, A, 2013)
"Obesity is a significant health problem world-wide, particularly in developed nations."( Vanlint, S, 2013)
"Obesity is a major health problem contributing to increased subfertility in males, as well as increased morbidity for diseases related to a decline in testosterone production with aging."( Cloutier, F; Landry, D; Martin, LJ, 2013)
"Obesity is becoming a health concern worldwide and metformin, a first line anti-diabetic drug, was associated with weight loss under different backgrounds."( Cong, W; Feng, Y; Ruan, K; Shen, L; Wang, B; Xu, D; Zhu, Y, 2013)
"Obesity is associated with enhanced reactive oxygen species (ROS) accumulation in adipose tissue."( Boudina, S; Ilkun, O; Pires, KM; Valente, M, 2014)
"Obesity is a world-wide epidemic associated with significant morbidity and mortality which costs billions of dollars per year."( Hermayer, K; Holes-Lewis, KA; Malcolm, R; O'Neil, PM, 2013)
"Obesity is not necessarily a predisposing factor for disease."( Camps, J; Hernández-Aguilera, A; Joven, J; Luciano-Mateo, F; Menéndez, JA; Riera-Borrull, M; Rodríguez-Gallego, E; Rull, A, 2013)
"Although obesity is a well-known risk factor for hypertension, the mechanisms by which hypertension develops in obese patients are not entirely clear."( Rosenthal, T; Segal-Lieberman, G, 2013)
"Obesity is one of the most serious public health problems worldwide in the 21st century."( Cho, H; Cho, YS; Choi, GD; Choi, K; Im, HY; Jang, H; Kim, CH; Kim, YJ; Ko, M; Kwon, OS; Lee, J; Pae, AN; Park, WK; Seo, YW; Tae, J; Yang, HY, 2013)
"To examine whether obesity is associated with enhanced PV growth measured by serial transrectal ultrasound (TRUS) measurements."( Andriole, G; Fleshner, N; Freedland, SJ; Gerber, L; Hamilton, RJ; Moreira, DM; Muller, RL; Parsons, JK, 2013)
"Obesity is the principle mechanism of chronic inflammation and IR in PCOS patients."( Gözdemir, E; Kafalı, H; Kaygusuz, I, 2013)
"Obesity is currently a worldwide pandemic."( Bai, XM; Bian, J; Liu, ZJ; Zhang, L; Zhao, YL, 2013)
"The fact that obesity is a prominent feature of Cushing's syndrome (systemic hypercortisolism of adrenocortical origin) stimulated a 40-year search for evidence of systemic hypercortisolism in human obesity."( Alfonso, B; Araki, T; Zumoff, B, 2013)
"Obesity is the most common nutritional disorder in today's dog population and the major risk factor for a number of related diseases."( Ceron, JJ; Tecles, F; Tvarijonaviciute, A, 2013)
"Obesity is now considered as a risk factor for breast cancer in postmenopausal women."( Billard, H; Caldefie-Chezet, F; Delort, L; Dubois, V; Vasson, MP, 2013)
"Obesity is related to atrophy and dysfunction of the hippocampus and hippocampal lesions may lead to increased appetite and weight gain."( Aggleton, JP; Baddeley, RJ; Jones, DK; Metzler-Baddeley, C; O'Sullivan, MJ, 2013)
"Obesity is an important risk factor for colon cancer in humans, and numerous studies have shown that a high fat diet enhances colon cancer development."( Al-Rabadi, L; Bugni, JM; Karagiannides, I; Pothoulakis, C; Stavrakis, D; Tuominen, I, 2013)
"Obesity is associated with an increased risk of infectious diseases."( Cabrera, RM; Ciolino, HP; Gulvady, AA; Jolly, CA, 2013)
"Obesity is a major public health concern associated with increased morbidity and mortality."( Kallikazaros, I; Kallistratos, MS; Katsi, V; Makris, T; Manolis, AJ; Marketou, M; Tousoulis, D; Vardas, P, 2013)
"Obesity is a risk factor for postmenopausal breast cancer and the place held by the adipose tissue and secretions (i."( Caldefie-Chézet, F; Delort, L; Dubois, V; Rossary, A; Vasson, MP, 2013)
"Obesity is a risk factor for stroke, but the early effects of high-fat diet (HFD) on neurovascular function and ischemic stroke outcomes remain unclear."( Brann, DW; Chawla, D; Didion, SP; Du, W; Ergul, A; Filosa, JA; Li, W; Lima, VV; Prakash, R; Tostes, RC; Zhang, Q, 2013)
"Obesity is a result of chronic overconsumption of calories relative to the amount of energy expended."( O'Connor, A; Orena, S; Swick, AG, 2013)
"Obesity is a significant risk factor for cancer."( Avramis, VI; Behan, JW; Butturini, A; Ehsanipour, EA; Mittelman, SD; Sheng, X; Wang, X, 2013)
"Obesity is associated with an increased risk of cardiomyopathy, and mechanisms linking the underlying risk and dietary factors are not well understood."( Cebova, M; Knowles, CJ; Pinz, IM, 2013)
"Sleep quality and obesity are associated with type 2 diabetes, hypertension, and metabolic syndrome."( Chang, CJ; Hung, HC; Lu, FH; Ou, HY; Wu, JS; Yang, YC, 2013)
"Obesity is associated with an overactivity of the endocannabinoid system with increased both plasmatic and visceral adipose tissue levels."( Bobbioni-Harsch, E; Carpentier, A; Golay, A; Pataky, Z, 2013)
"Obesity is a feature associated with some syndromes of cilia dysfunction, such as Bardet-Biedl syndrome (BBS) and Alström syndrome, as well as in several cilia mutant mouse models."( Berbari, NF; Kesterson, RA; Lewis, WR; Malarkey, EB; McNair, AD; Nagy, TR; Pasek, RC; Yazdi, SM; Yoder, BK, 2013)
"Obesity is associated with elevated risk of heart disease."( Liu, J; Lloyd, SG, 2013)
"Obesity is ranked as one of the top 10 global health problems and the major concern deriving from it is the exposure of the population to a vast array of chronic pathologies such as cardiovascular and musculoskeletal disorders, type 2 diabetes, cancer, such as colon, breast and endometrial cancer, together with psychological disorders derived from this condition."( Carta, F; Scozzafava, A; Supuran, CT, 2013)
"The prevalence of obesity is rising globally and in India."( Chopra, SM; Gulati, S; Gupta, R; Misra, A, 2013)
"Obesity is a chronic inflammatory condition with numerous metabolic consequences to the organism, highlighting its influence on bone mass."( Campos, RM; Carnier, J; Corgosinho, FC; da Silva, PL; Dâmaso, AR; de Mello, MT; de Piano, A; Masquio, DC; Sanches, PL; Tock, L; Tufik, S, 2013)
"Obesity is a risk factor for diabetes and metabolic syndrome, which are characterized by insulin resistance."( Al-Daghri, NM; Alkharfy, KM; Hussain, T; Krishnaswamy, S; Mohammed, AK; Yakout, SM, 2013)
"Obesity is a worldwide pandemic."( Blomain, ES; Kim, GW; Lin, JE; Waldman, SA, 2013)
"Obesity is associated with risks for mother and infant, and the mothers' dietary habits influence breast milk composition."( Ali, MA; Palme-Kilander, C; Strandvik, B; Yngve, A, 2013)
"Obesity is a health concern."( Durham, HA; Finley, J; Gao, Z; Goldsmith, F; Greenway, F; Keenan, MJ; Martin, RJ; McCutcheon, KL; Pelkman, C; Raggio, AM; Senevirathne, RN; Vidrine, K; Williams, C; Ye, J; Zhou, J, 2014)
"Obesity is now a major public health concern worldwide with increasing prevalence and a growing list of comorbidities and complications."( Conrad, AO; Cosentino, G; Uwaifo, GI, 2013)
"Obesity is considered as a systemic chronic low grade inflammation characterized by increased serum pro-inflammatory proteins and accumulation of macrophages within white adipose tissue (WAT) of obese patients."( Cianflone, K; Fisette, A; Gauvreau, D; Gupta, A; Tom, FQ, 2013)
"Obesity is a heterogeneous pathologic condition that is driven by interactions between multiple genetic and environmental factors."( Onigata, K, 2013)
"Obesity is characterised by chronic low-grade inflammation, and lycopene has been reported to display anti-inflammatory effects."( Conde, SJ; Correa, CR; Ferreira, AL; Imaizumi, E; Luvizotto, Rde A; Nascimento, AF; Pierine, DT; Yeum, KJ, 2013)
"Obesity is associated with low-grade chronic inflammation, which contributes to cellular dysfunction promoting metabolic disease."( Andres, A; Borengasser, SJ; Gomez-Acevedo, H; Saben, J; Shankar, K; Thakali, KM; Zhong, Y, 2013)
"Abdominal obesity is referred for as a common pathogenic root of multiple risk factors, which include insulin resistance, dyslipidemia, hypertension, and a pro-atherogenic and pro-inflammatory state."( Bajza, A; Literáti-Nagy, B; Literati-Nagy, Z; Mandl, J; Szilvássy, Z; Tory, K; Vígh, L, 2013)
"Obesity is associated with strong risks of development of chronic inflammatory liver disease and metabolic syndrome following a second hit."( Chatterjee, S; Das, S; Diehl, AM; Kadiiska, MB; Kumar, A; Michelotti, G; Seth, RK, 2013)
"Obesity is particularly associated with an increased consumption of palatable fat and sugar dense food and beverages."( Hegedusova, N; Hubka, P; Lackovicova, L; Mikuska, L; Mravec, B; Slavkovsky, P; Ukropec, J; Vrabcova, M, 2013)
"This obesity is caused by loss of expression of Pomc in Pomc- and Cart-expressing (Pomc/Cart) neurons in the arcuate nucleus, indicating an incomplete specification of anorexigenic first order neurons."( Ang, SL; Anthwal, N; Claxton, S; Collin, C; Gradwohl, G; Kessaris, N; Mellitzer, G; Pelling, M; Richardson, WD, 2013)
"Obesity is a known risk factor for postmenopausal breast cancer; it has been postulated that adipocytokines may mediate this association."( Gross, AL; Hoffman-Bolton, J; Newschaffer, CJ; Rifai, N; Visvanathan, K, 2013)
"Obesity is associated with numerous metabolic comorbidities."( Atkinson, RL; Cani, PD; Casteilla, L; Clement, K; Dhurandhar, NV; Gerard, P; Geurts, L; Nam, JH; Nieuwdorp, M; Sørensen, TI; Trovato, G; Vidal-Puig, A; Vijay-Kumar, M, 2013)
"Obesity is a strong risk factor for hypertension, but the mechanisms by which obesity leads to hypertension are incompletely understood."( Andersen, UB; Asferg, CL; Christiansen, M; Esler, M; Goetze, JP; Hedley, PL; Jeppesen, JL; Linneberg, A; Møller, DV; Nielsen, SJ, 2013)
"Overweight and obesity are established risk factors for venous thromboembolism (VTE)."( Belaj, K; Brodmann, M; Bruckenberger, R; Froehlich, H; Gary, T; Hackl, G; Hafner, F; Pilger, E; Zebisch, A, 2013)
"Overweight and obesity are becoming global health problems."( Obeid, OA, 2013)
"Obesity is associated with hypertriglyceridemia and elevated circulating free fatty acids (FFA), resulting in endothelial dysfunction."( Chen, B; Chen, G; Chen, L; Gui, L; Huang, D; Lu, Y; Qian, L; Zhang, Q, 2013)
"Although obesity is a risk factor for colorectal adenoma (CRA), there has yet to be any study of the risks of CRA in MHO individuals."( Chang, Y; Jung, HS; Kim, CW; Kwon, MJ; Park, HS; Park, SK; Ryu, S; Shin, H; Sung, E; Yun, KE, 2013)
"Rates of obesity are increasing worldwide."( Gurney, EP; Murthy, AS, 2013)
"Obesity is epidemic and is associated with increased blood pressure, which often manifests as treatment-resistant hypertension."( Brook, RD; Byrd, JB, 2014)
"Obesity is important for the development of type-2 diabetes as a result of obesity-induced insulin resistance accompanied by impaired compensation of insulin secretion from pancreatic beta cells."( Cai, D; Chen, Q; Chen, X; Wu, C; Wu, J; Xu, Z; Zhang, H, 2013)
"Overweight and obesity are associated with increased high-sensitivity C-reactive protein (hsCRP) levels."( Bray, GA; LeBoff, MS; Nicklas, JM; Ridker, PM; Rood, JC; Sacks, FM; Smith, SR, 2013)
"Obesity is characterized by a pro-inflammatory state commonly associated with type 2 diabetes and fat-liver disease."( Alvarez-Leite, JI; Andrade, JM; Feltenberger, JD; Fernandes, LR; Santos, RA; Santos, SH; Sinisterra, RD; Sousa, FB, 2013)
"Obesity is an epidemic, calling for innovative and reliable pharmacological strategies."( Borrelli, E; Chandy, KG; Eckel-Mahan, KL; Griffey, SM; Halbout, B; Iadonato, S; Koehne, A; Mirbolooki, MR; Mukherjee, J; Pedersen, B; Sassone-Corsi, P; Schmunk, G; Tjong, I; Upadhyay, SK; Wang, PH, 2013)
"Obesity is a critical risk factor for the development of metabolic syndrome, and many obese animal models are used to investigate the mechanisms responsible for the appearance of symptoms."( Bannai, M; Maruyama, K; Murakami, N; Nakahara, K; Okame, R; Suzuki, Y, 2013)
"Obesity is a major health problem in people with intellectual disabilities."( Camacho, A; Diaz, AJ; Fornieles, G; Garcia, N; Ordonez, FJ; Rosety, I; Rosety, MA; Rosety-Rodriguez, M, 2014)
"Obesity is a chronic inflammatory disease and a risk factor for disorders such as heart disease, diabetes, and cancer."( Brabb, T; Fierce, Y; Maggio-Price, L; Paik, J; Treuting, PM, 2013)
"Obesity is associated with reduced operating lung volume."( Berend, N; King, GG; Mahadev, S; Salome, CM, 2013)
"Obesity is one of the greatest public health challenges of the 21st century."( Bak, S; Delhanty, P; Fani, L; van den Akker, EL; van Rossum, EF, 2014)
"Obesity is a pandemic and is associated with multiple medical problems including subfertility."( Polotsky, AJ; Stephens, SM, 2013)
"Obesity is associated with aberrant sodium/potassium-ATPase (Na(+)/K(+)-ATPase) activity, apparently linked to hyperglycemic hyperinsulinemia, which may repress or inactivate the enzyme."( Bjelogrlic, P; Haidara, M; Isenovic, ER; Jovanovic, A; Katsiki, N; Obradovic, M; Rizzo, M; Stewart, AJ, 2013)
"Severe obesity is associated with decreased long-term survival only in patients with LGA primary disease; however, application of CRS/HIPEC still offers meaningful prolongation of life."( Levine, EA; Randle, RW; Shen, P; Stewart, JH; Swett, KR; Swords, DS; Votanopoulos, KI, 2013)
"Obesity is an epidemic associated with significant morbidity."( Berlie, HD; Hurren, KM, 2013)
"Obesity is associated with increased activity of two lipid signaling systems (endocannabinoids [ECs] and ceramides), with both being implicated in insulin resistance."( Cinar, R; Godlewski, G; Harvey-White, J; Jourdan, T; Kunos, G; Liu, J; Mukhopadhyay, B; Tam, J, 2014)
"Obesity is considered a clinical risk sign for Legg-Calvé-Perthes disease (LCPD)."( Kim, JR; Kwon, KS; Lee, D; Lee, JH; Park, BH; Zhou, L, 2013)
"Obesity is also associated with hyperlipidaemia and cholesterol inhibits myometrial contractility in vitro."( Dekker, GA; Fyfe, EM; Groom, KM; McCowan, LM; Rivers, KS; Thiyagarajan, KP; Thompson, JM, 2013)
"Obesity is markedly associated with abnormal bone density indicating the importance of adipocytes in bone metabolism."( Chen, A; Du, Y; Guo, F; Hang, S; Xu, F; Xu, T, 2013)
"Obesity is a chronic metabolic disease that affects an increasing number of people around the world."( Ahn, SM; Han, N; Ji, E; Kim, H; Oh, JM, 2014)
"Maternal obesity is associated with increased risk of childhood ICS use up to approximately 12 years of age, but only in girls after this age."( Bråbäck, L; Ekeus, C; Forsberg, B; Hjern, A; Lowe, AJ; Rajaleid, K, 2013)
"Obesity is associated with hyperleptinemia and hypothalamic leptin resistance as well as an increased risk to develop cardiac hypertrophy and heart failure."( Didié, M; Gogiraju, R; Hasenfuss, G; Konstantinides, S; Leifheit-Nestler, M; Schäfer, K; Wagner, NM, 2013)
"Obesity is recognized as a major worldwide health problem."( da Silva, AA; do Carmo, JM; Dubinion, J; Ebaady, SH; Hall, JE; Sessums, PO; Wang, Z, 2013)
"The prevalence of obesity is increasing which becomes worrisome due to its association with several diseases and certain types of cancers."( Jiang, Y; King, B; Standard, J; Su, X; Wang, W; Xie, L; Xu, J, 2013)
"Obesity is a leading cause of morbidity and mortality worldwide."( Agahi, A; Murphy, KG, 2014)
"Obesity is prevalent worldwide and is a major risk factor for many diseases including renal complications."( Cui, W; Maimaitiyiming, H; Norman, H; Qi, X; Wang, S, 2013)
"Obesity is a global epidemic associated with aging-like cellular processes; in both aging and obesity, resistance to hormones such as insulin and leptin can be observed."( Caron, A; Carter, S; Picard, F; Richard, D, 2013)
"Obesity is an increasing health problem."( Goebel-Stengel, M; Hu, E; Karasawa, H; Pisegna, JR; Stengel, A; Taché, Y; Wang, L, 2013)
"Obesity is a major risk factor for type 2 diabetes and cardiovascular diseases."( Cheng, H; Ding, Y; Hou, N; Hu, X; Mao, J; Wang, J; Xiao, Y; Yang, C; Zhang, X, 2013)
"Obesity is of importance among the risk factors predisposing for chronic venous disorders (CVD)."( Chudek, J; Kocełak, P; Owczarek, A; Ziaja, D; Ziaja, K, 2013)
"Obesity is frequently present in women with the polycystic ovary syndrome (PCOS) and aggravates insulin resistance (IR) and hyperandrogenemia."( Chatzis, P; Kandaraki, EA; Katsikis, I; Panidis, D; Papadakis, E; Tsourdi, EA; Tziomalos, K, 2014)
"Obesity is often accompanied by hyperuricemia."( Funahashi, T; Imaizumi, K; Kato, K; Maeda, N; Nagao, H; Nakatsuji, H; Nishizawa, H; Sekimoto, R; Shimomura, I; Shirakura, T; Takahashi, H; Tamura, M; Tochino, Y; Tsushima, Y, 2013)
"Obesity is a chronic inflammatory state characterized by infiltration of adipose tissue by immune cell populations, including T lymphocytes."( Buckner, JH; Chait, A; Ding, Y; Getz, GS; Goodspeed, L; O'Brien, K; Reardon, CA; Subramanian, S; Turner, MS; Wang, S, 2013)
"Obesity is a primary risk factor for multiple metabolic disorders."( Bhanot, S; Chakravarty, K; Manchem, VP; McCaleb, ML; Monia, BP; Watts, LM; Yu, XX, 2013)
"Obesity is associated with insulin resistance and abnormal peripheral tissue glucose uptake."( Ang, J; Bonala, S; Chua, H; Gluckman, PD; Kambadur, R; Lee, M; Lee, YS; Leow, MK; Lim, R; Lokireddy, S; McFarlane, C; Meng, KC; Sharma, M; Shyong, TE; Sreekanth, P, 2013)
"Obesity is associated with Barrett's esophagus (BE) and with changes in circulating levels of adipokines (leptin and adiponectin) and cytokines."( Alsarraj, A; El-Serag, HB; Fitzgerald, S; Garcia, JM; Kramer, J; Ramsey, D; Splenser, AE, 2014)
"Obesity is associated with a low-grade inflammation including moderately increased serum levels of the acute phase protein serum amyloid A (SAA)."( Ahlin, S; Olsson, B; Olsson, M; Sjöholm, K; Svensson, PA, 2013)
"Treating obesity is crucial as it will ultimately result in the prevention of many related chronic diseases and will decrease morbidity and mortality."( Boulghassoul-Pietrzykowska, N; Franceschelli, J; Still, C, 2013)
"Adult and childhood obesity is an independent risk factor in development of chronic kidney disease (CKD) and its progression to end-stage kidney disease."( Arany, I; Clark, JS; Dixit, M; Juncos, LA; Reed, DK, 2013)
"Obesity is reported to be associated with excessive growth of adipocyte mass tissue as a result of increases in the number and size of adipocytes differentiated from preadipocytes."( Jeong, EJ; Kang, J; Kim, HP; Kim, YC; Lee, M; Lee, SH; Sung, SH; Yang, H, 2013)
"Obesity is associated with impaired microvascular endothelial function."( Al-Tahami, BA; Awang, SA; Bee, YT; Ismail, AA; Rasool, AH; Salha Wan Abdul Rani, WR; Sanip, Z, 2015)
"Because obesity is prevalent in polycystic ovary syndrome (PCOS), it is not surprising that patients with PCOS present altered adipokine levels and increased prevalence of metabolic syndrome."( Carmina, E, 2013)
"Obesity is associated with an increased body aromatisation and may be a cause of insufficient estradiol depletion."( Dressel-Ban, G; Dubsky, P; Exner, R; Fitzal, F; Gnant, M; Hadji, P; Königsberg, R; Maroske, M; Pfeiler, G; Seifert, M; Singer, C; Zellinger, J, 2013)
"Obesity is a major public health concern affecting an increasing proportion of reproductive-aged women."( Burke, AE; Robinson, JA, 2013)
"Obesity is a recognized risk factor for both the development and progression of chronic kidney disease (CKD)."( Bouquegneau, A; Cavalier, E; Delanaye, P; Flamant, M; Krzesinski, JM; Rorive, M; Vidal-Petiot, E; Vrtovsnik, F, 2013)
"Obesity is a risk factor for chronic venous disease."( Baumann, F; Baumgartner, I; Diehm, N; Egermann, U; Engelberger, RP; Fahrni, J; Indermühle, A; Kucher, N; Laederach, K; Willenberg, T, 2014)
"Diet-induced obesity is commonly associated with leptin resistance, and attenuated leptin signaling contributes to the progression of obesity."( Chen, Y; Guo, F; Li, Z; Liu, B; Liu, Y; Pan, Y; Wang, L; Wang, X; Xia, T; Xiao, F; Zhang, Y; Zhu, L, 2013)
"Obesity is now recognised as a low grade, chronic inflammatory disease that is linked to a myriad of disorders including cancer, cardiovascular disease and type 2 diabetes (T2D)."( Febbraio, MA; Kammoun, HL; Kraakman, MJ, 2014)
"Obesity is an emerging risk factor for chronic kidney disease (CKD) in the developed world."( Coutinho, AK; Glancey, GR, 2013)
"Obesity is characterized by poor collateral vessel formation, a process involving vascular endothelial growth factor (VEGF) action on vascular smooth muscle cells (VSMC)."( Anfossi, G; Barale, C; Doronzo, G; Mattiello, L; Russo, I; Trovati, M; Viretto, M, 2013)
"Obesity is an increasing epidemic worldwide; however, little is known about effects of obesity produced by high-fat diet (HFD) on the cerebral circulation."( Chen, X; Didion, SP; Ergul, A; Faraci, FM; Faulkner, JL; Filosa, J; Kinzenbaw, DA; Lynch, CM; Mezzetti, E; Zhan, S, 2013)
"Obesity is a key risk factor for the development of colon cancer; however, the endocrine/paracrine/metabolic networks mediating this connection are poorly understood."( Kirshtein, B; Nimri, L; Rudich, A; Schwartz, B; Tarnovscki, T; Yehuda-Shnaidman, E, 2013)
"Although obesity is a key predisposing risk factor in the development of insulin resistance (IR) and type 2 diabetes mellitus, not all obese individuals develop IR."( Davies, PS; Gray, B; Muhlhausler, BS; Vitetta, L, 2013)
"Obesity is becoming increasingly prevalent and it has been linked to poor breast cancer outcomes."( Goodwin, PJ, 2013)
"Obesity is often regarded as a stress state and an immune disease, both of which may contribute to pregnancy failure."( Arck, PC; Douglas, AJ; Parker, VJ; Solano, ME, 2014)
"Obesity is associated with chronic noncancer pain."( Ahmed, A; Bayliss, EA; Boudreau, D; DeBar, L; Donahoo, WT; Elliott, TE; Fisher, D; Newcomer, SR; Pawloski, PA; Raebel, MA; Reifler, LM, 2013)
"Obesity is associated with left ventricular diastolic dysfunction and altered heart rate variability, as well as pulmonary dysfunction."( Bastien, M; Boulet, LP; Gagnon-Audet, AA; Martin, J; Poirier, P; Simard, S; Turcotte, H, 2013)
"Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes."( Allard, JS; Baur, JA; Belman, JP; Bernier, M; Bogan, JS; de Cabo, R; Egan, JM; Ferrucci, L; Herbert, RL; Jimenez-Gomez, Y; Lewis, K; Longo, DL; Malagon, MM; Martin-Montalvo, A; Mattison, JA; Moaddel, R; Morrell, CH; Navas, P; Palacios, HH; Pearson, KJ; Sanghvi, M; Sossong, AM; Tilmont, EM; Ward, TM; Younts, CM, 2013)
"Obesity is a growing pandemic, and related health and economic costs are staggering."( Blomain, ES; Kim, GW; Lin, JE; Waldman, SA, 2014)
"Obesity is a major risk factor for the development of asthma, and causes severe, uncontrolled disease that responds poorly to therapy."( Dixon, AE; Sideleva, O, 2014)
"Obesity is considered a chronic inflammatory condition that enhances the risk of numerous inflammatory diseases, including diabetes and cardiovascular disease."( Acevedo, EO; Huang, CJ; Mari, DC; Randazzo, C; Shibata, Y, 2014)
"Obesity is a chronic disease, and it requires chronic therapy."( Baretić, M, 2013)
"Obesity is a heterogeneous construct that, despite multiple and diverse attempts, has been difficult to treat."( Potenza, MN; Yau, YH, 2013)
"Obesity is a major risk factor for OA."( Koskinen, A; Moilanen, E; Vuolteenaho, K, 2014)
"Maternal obesity is associated with obesity and metabolic disorders in offspring."( Gray, C; Li, M; Reynolds, CM; Sloboda, DM; Vickers, MH, 2013)
"On the other hand, obesity is associated with excessive daytime sleepiness in humans and promotes sleep in different rodent models of obesity."( Amici, R; Cerri, M; Del Vecchio, F; Di Cristoforo, A; Luppi, M; Martelli, D; Perez, E; Tupone, D; Zamboni, G, 2014)
"The prevalence of obesity is associated with many health-related problems."( Chagalamarri, J; Jangra, S; Kumar Kavadi, P; Pothuraju, R; Sharma, RK, 2014)
"Obesity is characterized by an increased recruitment of proinflammatory macrophages to the adipose tissue (AT), leading to systemic inflammation and metabolic disease."( Chapes, SK; Dib, LH; Fleming, SD; Melgarejo, T; Ortega, MT, 2014)
"Obesity is increasingly prevalent in the United States."( Craig, EV; Gulotta, LV; Li, X; Nguyen, JT; Warren, RF; Williams, PN, 2013)
"Obesity is a growing public health problem."( Borgland, SL; Champagne, FA; Hill, MN; Hurd, YL; Karatsoreos, IN; Thaler, JP, 2013)
"Lastly, obesity is a major confounding factor for leukotriene activation in OSA."( Bäck, M; Gautier-Veyret, E; Lévy, P; Pépin, JL; Stanke-Labesque, F, 2014)
"Obesity is a risk of cardiovascular diseases."( Chang, WW; Chen, Y; Ding, LL; Guo, DX; He, LP; Jin, YL; Li, CP; Li, J; Ren, XH; Song, XL; Tang, H; Yao, YS, 2013)
"Obesity is an inflammatory condition and inflammatory cells and their secretion of pro-inflammatory molecules contribute to the pathogenesis of obesity."( Byun, JK; Cho, ML; Hong, YS; Jhun, JY; Ju, JH; Kim, EK; Kim, HY; Min, JK; Moon, SJ; Park, SH; Yang, EJ; Yoon, BY, 2013)
"While obesity is known to augment vasoconstrictor prostanoid activity in endothelial cells, less is known about factors released from fat tissue surrounding arteries (perivascular adipose)."( Barton, M; Fredette, NC; Meyer, MR; Prossnitz, ER, 2013)
"Obesity is a result of adipocyte hypertrophy followed by hyperplasia."( Beg, M; Chauhan, P; Gaikwad, AN; Rajan, S; Saini, D; Shankar, K; Srivastava, MN; Varshney, S; Yadav, PP, 2014)
"However, obesity is one risk factor for ESWL failure and higher procedural hazard."( Berssenbrügge, C; Domagk, D; Domschke, W; Floer, M; Heinzow, HS; Herrmann, E; Lenze, F; Meister, T; Rothenbächer, H; Ullerich, H, 2014)
"Obesity is a worldwide epidemic with a high prevalence of comorbidities, including alterations in bone mineral metabolism."( Campos, RM; Carnier, J; Corgosinho, FC; Dâmaso, AR; de Mello, MT; de Piano, A; Foschini, D; Masquio, DC; Sanches, PL; Silva, PL; Tock, L; Tufik, S, 2014)
"visceral, obesity is associated with insulin resistance and impaired protein synthesis."( Jensen, MD; Liebau, F; Nair, KS; Rooyackers, O, 2014)
"In particular, when obesity is present, lifestyle intervention should be always considered, and if necessary combined with pharmacotherapy."( Gambineri, A; Pasquali, R, 2014)
"Obesity is strongly associated with the prevalence of nonalcoholic fatty liver disease (NAFLD) in adult and pediatric populations."( Yilmaz, Y; Younossi, ZM, 2014)
"Diabetes and obesity are associated with advanced fibrosis and increased risk of hepatocellular carcinoma in CHB."( Pais, R; Ratziu, V; Rusu, E, 2014)
"Obesity is a public health problem contributing to morbidity and mortality from metabolic syndrome."( Aouani, E; Charradi, K; Elkahoui, S; Limam, F; Mahmoudi, M, 2013)
"The prevalence of obesity is high resulting from chronic imbalances between energy intake and expenditure."( Befort, CA; Breslin, FJ; Burns, JM; Donnelly, JE; Gibson, CA; Herrmann, SD; Honas, JJ; Lambourne, K; Lepping, RJ; Martin, LE; Savage, CR; Smith, BK; Sullivan, DK; Washburn, RA; Willis, EA; Yeh, HW, 2014)
"Obesity is a global public health threat."( Ge, S; Guo, X; He, Z; Sun, R; Tian, H; Wang, X; Zhang, Z, 2013)
"Although obesity is considered one of the risk factors for thromboembolism, morbidly obese patients were excluded from most clinical trials; therefore, the appropriate enoxaparin preventive dose is not clear in this population."( Alsharhan, M; Cooper, MR; Durand, C; Willett, KC, 2013)
"Obesity is a pathological condition which increases the risk for cardiovascular disease."( Ananthanarayanan, PH; Harichandrakumar, KT; Ikkruthi, S; Nandeesha, H; Rajappa, M; Satheesh, S; Sundar, I, 2014)
"Obesity is a strong modifier of diabetes risk, and can account for not only a large proportion of the epidemic of type 2 diabetes in Asia but also the ever-increasing number of adolescents with type 2 diabetes."( Cai, M; Caprio, S; Groop, L; Santoro, N; Tuomi, T; Weng, J, 2014)
"Obesity is becoming one of the global epidemics of the 21st century."( Ding, X; Fan, S; Huang, C; Jiang, D; Li, Y; Lu, Y; Xi, W; Zhang, Y; Zhou, Z, 2013)
"Obesity is a complex heterogeneous disease that is caused by genes, environmental factors, and the interaction between the two."( Güven, H; Rüstemoğlu, A; Şahın, S; Taşliyurt, T; Tekcan, A; Yığıt, S, 2013)
"Obesity is well known cause of various diseases."( Car, J; Debska, A; Gebska-Kuczerowska, A; Gromulska, L; Supranowicz, P; Wysocki, MJ, 2013)
"Its relation to obesity is due to increased reactive oxygen species and/or decreased glutathione (GSH) antioxidant metabolism."( Arola, L; Bladé, C; Díaz, S; Fernández-Iglesias, A; Mulero, M; Pajuelo, D; Quesada, H; Salvadó, MJ, 2014)
"Obesity is defined by excessive lipid accumulation."( Attle, SJ; Brulte, GB; Chatfield, DA; Finley, KD; Harris, GL; Herr, DR; Walls, ML; Walls, SM, 2013)
"Obesity is highly associated with colon cancer development."( Fukuda, H; Hippo, Y; Igarashi, M; Nakagama, H; Ochiai, M, 2014)
"Although obesity is a major risk factor for nonalcoholic fatty liver (NAFL), not all individuals with obesity develop the condition, suggesting that other factors such as diet may also contribute to NAFL development."( Adams, LA; Ayonrinde, OT; Beilin, LJ; Bremner, AP; Mori, TA; Oddy, WH; Olynyk, JK; OʼSullivan, TA; Sherriff, JL, 2014)
"Obesity is an important risk factor for atrial fibrillation (AF)."( Chen, SA; Chen, YC; Chen, YJ; Huang, JH; Huang, SS; Lin, YJ; Lin, YK, 2013)
"Obesity is a risk factor for complicated influenza A/H1N1 disease and poor vaccine immunogenicity."( Grill, DE; Jacobson, RM; Larrabee, BR; Ovsyannikova, IG; Poland, GA; White, SJ, 2014)
"Clinical obesity is a complex metabolic disorder affecting one in three adults."( Awumey, EM; Cullen, JM; Gonzalez, FJ; Gyamfi, MA; Richardson, RM; Spruiell, K, 2014)
"Obesity is a chronic metabolic disorder caused by imbalance between energy intake and expenditure, and is one of the principal causative factors in the development of metabolic syndrome, diabetes and cancer."( Awasthi, S; Figarola, JL; Gugiu, BG; Rahbar, S; Singhal, P; Singhal, SS, 2013)
"Obesity is a global epidemic associated with a series of secondary complications and comorbid diseases such as diabetes mellitus, cardiovascular disease, sleep-breathing disorders, and certain forms of cancer."( Jauch-Chara, K; Oltmanns, KM, 2014)
"Rising levels of obesity are a global problem that is being exported from affluent to developing nations through the gradual "westernization of lifestyle"."( Alharbi, KK; Khan, IA; Syed, R, 2014)
"Obesity is a world problem that requires a better understanding of its physiological and genetic basis, as well as the mechanisms by which the hypothalamus controls feeding behavior."( Báez-Ruiz, A; Cárdenas-Vázquez, R; Carmona-Alcocer, V; Carmona-Castro, A; Díaz-Muñoz, M; Fuentes-Granados, C; Luna-Moreno, D; Manuel, MA, 2014)
"Obesity is considered the single most important risk factor for cardiovascular morbidity and mortality."( Andersen, UB; Baandrup, L; Broberg, BV; Ebdrup, BH; Fagerlund, B; Glenthøj, BY; Ishøy, PL; Jørgensen, NR; Knop, FK; Rostrup, E, 2014)
"Low BNP in obesity is postulated to be due to IR; however, it has been difficult to define the role of IR independent of obesity."( Bradham, WS; Gebretsadik, T; Oeser, A; Ormseth, MJ; Shintani, A; Solus, JF; Stein, CM, 2014)
"Obesity is a chronic inflammatory state characterized by altered adipokine production and increased levels of inflammatory cytokines."( Ahn, J; Kim, J, 2014)
"Obesity is non-infectious pandemic."( Luzina, EV; Tomina, EA; Zhilina, AA, 2013)
"Obesity is associated with metabolic disorders."( Choi, KM; Hong, JT; Kim, SJ; Kim, W; Lee, MK; Lee, YM; Lee, YS; Shin, KO; Yoo, HS; Yu, JY; Yun, YP, 2014)
"Obesity is a serious health problem associated with the pathogenesis of various metabolic diseases."( Arellano-Mendoza, M; Cruz-Laguna, E; Escalante, B; Gámez-Méndez, AM; Rios, A; Vargas-Robles, H, 2014)
"Obesity is associated with increased infarct volumes and adverse outcomes following ischemic stroke."( Chen, Y; Fang, X; Jiang, Y; Xu, J; Yang, Z; Zhang, Y, 2014)
"Obesity is prevalent in the pediatric population, and current warfarin dosing methods should be evaluated in obese pediatric patients."( Bomgaars, LR; Moffett, BS, 2014)
"Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases."( Baek, SH; Chung, HJ; D'Souza, R; Hong, ST; Jeon, Y; Kim, HJ; Kweon, SJ; Lee, HK, 2014)
"Obesity is strongly related to type-2 diabetes (T2DM), but there is a subset of obese individuals that remains relatively insulin sensitive and metabolically healthy."( Berends, FJ; Ioan-Facsinay, A; Koning, F; Lips, MA; Pijl, H; Toes, R; van Beek, L; van Harmelen, V; Visser, A; Willems van Dijk, K, 2014)
"Obesity is a disease that develops as a result of long-term positive energy balance."( Chudek, J; Kocełak, P; Olszanecka-Glinianowicz, M; Zak-Gołąb, A, 2014)
"Obesity is a widespread health concern that is associated with an increased prevalence of hypertension and cardiovascular disease."( de Kloet, AD; Hiller, H; Nguyen, D; Pioquinto, DJ; Smith, JA; Sumners, C; Wang, L, 2014)
"Obesity is associated with increased production of inflammatory mediators in adipose tissue, which contributes to chronic inflammation and insulin resistance."( Fan, N; Hou, Y; Liu, R; Peng, L; Peng, Y; Shen, W; Sun, H; Wang, Y; Xia, Z; Zhang, L, 2014)
"Obesity is associated with numerous health complications; however, a subgroup of obese individuals (termed the metabolically healthy obese or MHO) appear to have lower risk for complications such as type 2 diabetes and cardiovascular disease."( Badawi, A; Badoud, F; Buchholz, A; Mutch, DM; Perreault, M; Stephenson, S; Zulyniak, MA, 2014)
"Obesity is a major health problem."( Doseyici, S; Erbay, E; Mehmetoglu, I; Toker, A; Yerlikaya, FH, 2014)
"Obesity is a modern plague in industrialized and developing countries, and currently overweight and obesity cause more deaths worldwide than underweight."( Gras, J, 2013)
"Obesity is associated with diabetes and hypertension, two major risk factors for chronic kidney disease (CKD)."( Liao, J; Sabanayagam, C; Sethi, S; Teo, BW; Wong, TY, 2014)
"Obesity is linked significantly to adipose tissue dysfunction and to alteration of adipokines in blood; in particular, obesity-induced inflammation is thought to be an important link between obesity and colorectal cancer."( Joshi, RK; Lee, SA, 2014)
"Obesity is a global health problem that increases the risk of several common diseases."( Hattori, T; Horikawa, Y; Iizuka, K; Takeda, J, 2014)
"Obesity is associated with vascular diseases that are often attributed to vascular oxidative stress."( Cai, H; Harrison, DG; Itani, H; Lob, HE; Siu, KL; Youn, JY, 2014)
"Obesity is one of the largest health problems facing the world today."( Gao, X; Hao, CJ; He, X; Li, CG; Li, W; Li, XN; Speakman, JR; Wei, AH; Wei, ZB; Yang, L; Zang, DJ; Zhang, Z; Zhao, J; Zhen, XC, 2014)
"Obesity is associated with certain types of cancer, including gastric cancer."( Choi, HS; Hahm, JS; Lee, KN; Lee, OY; Lee, YY; Paik, SS; Park, HK; Yang, SY; Yoon, BC, 2014)
"Obesity is a substantial cardiovascular risk factor, and recently, large trials of lifestyle and surgical (e."( Golden, SH; Joseph, JJ, 2014)
"Maternal obesity is a risk factor for metabolic diseases in offspring."( Fang, Y; Feng, X; Lyv, Y; Wu, Z; Xu, H; Xu, Y; Zhao, J, 2014)
"Obesity is a major modifiable risk factor associated with most chronic diseases."( Boo, NY; Chew, WF; Choo, KB; Leong, PP; Masyita, M; Yap, SF; Zin, T, 2014)
"Obesity is associated with a higher risk of aggressive prostate cancer and alters circulating levels of insulin and adiponectin, two hormones that influence biologic processes implicated in carcinogenesis."( Gapstur, SM; Jacobs, EJ; Stevens, VL; Sun, J, 2014)
"The pandemic of obesity is a global public health concern."( Amanguli, A; Chen, C; Cong, L; Gu, Y; Hao, XL; Jing, MX; Li, F; Li, L; Li, SG; Ma, ZP; Mohemaiti, M; Saimaiti, A; Simayi, D; Tao, L; Wang, W; Wang, YH; Yang, L; Zhan, JQ; Zhang, HY; Zhang, W; Zhang, WJ; Zhao, J; Zou, XG, 2014)
"Obesity is a growing health problem and associated with immune dysfunction."( Annecke, T; Caldwell, CC; Conzen, P; Huber, N; Johnson, BL; Martignoni, A; Schlag, C; Siegl, D; Tschöp, J, 2014)
"Obesity is one of the greatest public health challenges world wide and its prevalence has increased during the past 20-30 years."( Árnarson, EÖ; Guðmundsson, L; Lárusdóttir, H; Saevarsdóttir, H; Steingrimsdóttir, L, 2014)
"Obesity is a substantial risk factor for developing asthma, but the molecular mechanisms underlying this relationship are unclear."( Fryer, AD; Jacoby, DB; Nie, Z, 2014)
"Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals termed metabolically healthy but obese (MHO) appears relatively protected from the development of cardiometabolic complications."( Gauthier, MS; Geng, D; Karelis, AD; Prud'homme, D; Rabasa-Lhoret, R; Ruzzin, J; van Bavel, B, 2014)
"Obesity is a major epidemic of our time and is associated with diseases such as metabolic syndrome, type 2 diabetes mellitus and atherosclerotic cardiovascular disease."( Chatzigeorgiou, A; Kandaraki, E; Koutsilieris, M; Papavassiliou, AG, 2014)
"Aging and obesity are linked to oxidative stress."( Aizenbud, D; Levy, Y; Mitki, T; Narotzki, B; Reznick, AZ, 2014)
"Interestingly, obesity is not due to hyperphagia or decreased energy expenditure, but is associated with increased de novo lipogenesis in the liver."( Badurek, S; Brönneke, HS; Geibel, M; Horn, JM; Koudelka, J; Minichiello, L; Vatanashevanopakorn, C; Wunderlich, CM; Wunderlich, FT, 2014)
"Once obesity is established, DIO rats strongly defend their increased body weight against caloric restriction."( Guèvremont, G; Lenglos, C; Mitra, A; Timofeeva, E, 2014)
"Obesity is characterized by a generalized increase of adipose tissue, high production of adipocytokines and presence of oxidative systemic stress."( Ceballos, GM; García, JR; Gutiérrez, L; Olivares, IM; Rincón, Mde J, 2015)
"Maternal obesity is a risk factor for the development of metabolic syndrome and childhood obesity, and early overnutrition seems to induce the development of pathologies in adulthood, including insulin resistance, cardiovascular diseases, type 2 diabetes mellitus, and a higher BMI."( Aranda, BC; da Rocha, CF; de Souza, MA; Franci, CR; Guilherme, C; Jacobs, S; Reis, AR; Sanvitto, GL; Teixeira, DS, 2014)
"Obesity is a contemporary health problem of rapidly increasing prevalence."( Ahmed, EU; Ahmed, S; Hargreaves, GA; Kashem, MA; McGregor, IS; Sarker, R, 2014)
"Obesity is a pandemic with several significant adverse health outcomes."( Agrawal, V; Bhattacharya, A; Rao, BB, 2014)
"Obesity is increasingly prevalent, strongly associated with nonalcoholic liver disease, and a risk factor for numerous cancers."( Armstrong, MJ; Dowman, JK; Hopkins, LJ; Houlihan, DD; Hübscher, SG; Lalor, PF; Newsome, PN; Nikolaou, N; Reynolds, GM; Shaw, JC; Tomlinson, JW, 2014)
"Obesity is associated with chronic low-grade inflammation and oxidative stress that blunt insulin response in its target tissues, leading to insulin resistance (IR)."( Amouzou, C; Bisbal, C; Breuker, C; Fabre, O; Kitzmann, M; Mercier, J; Salehzada, T, 2014)
"Obesity is an abnormal accumulation of body fat directly proportional to reduced life expectancy."( Anburajan, M; Kishore Mohan, KB, 2014)
"Obesity is a disorder often accompanied by a heightened state of systemic inflammation and immunoactivation."( Akhlaghi, S; Ferns, G; Ganjali, S; Ghayour-Mobarhan, M; Jamialahmadi, K; Mahdipour, E; Parizadeh, SM; Sahebkar, A; Torabi, S, 2014)
"Recognizing obesity is associated with increased levels of VEGF, the main target of bevacizumab, we sought to assess if adiposity, measured in terms of BMI, subcutaneous fat area (SFA), and visceral fat area (VFA) was prognostic."( Benbrook, DM; Ding, K; McMeekin, DS; Moore, KN; Nelson, T; Penaroza, S; Slaughter, KN; Thai, T; Thavathiru, E, 2014)
"Obesity is an increasing health problem that is reported to influence chemotherapy dosing."( Au-Yeung, G; Bressel, M; DeFazio, A; Fereday, S; Mileshkin, L; Webb, PM, 2014)
"Obesity is common in ovarian cancer patients, and commonly results in lower chemotherapy dosing than recommended."( Au-Yeung, G; Bressel, M; DeFazio, A; Fereday, S; Mileshkin, L; Webb, PM, 2014)
"Age and obesity are accompanied by leptin resistance."( Balaskó, M; Füredi, N; Mikó, A; Pétervári, E; Rostás, I; Soós, S; Székely, M; Tenk, J, 2014)
"In PHPT patients, obesity is a risk factor for hypercalciuria and nephrolithiasis and is protective against osteoporosis."( Adams-Huet, B; Grange, JS; Holt, SA; Maalouf, NM; Nwariaku, FE; Rabaglia, JL; Tran, H; Woodruff, SL, 2014)
"The treatment of obesity is often met with a myriad of challenges in the primary care setting."( Gadde, KM; Xiong, GL, 2014)
"Obesity is a multifactorial disease, with epigenetic alterations."( dos Santos, JS; Pretti da Cunha Tirapelli, D; Salgado, W; Viesti A Collares, R, 2014)
"Maternal obesity is associated with metabolic alterations and dysregulation of redox balance in the mother-placenta - fetus unit."( Karaouzene, N; Loukidi, B; Malti, A; Malti, N; Merzouk, H; Merzouk, SA; Narce, M, 2014)
"Obesity is a pandemic and a serious global health concern."( Arnoldussen, IA; Gustafson, DR; Kiliaan, AJ, 2014)
"Obesity is a nutritional disorder associated with many health problems such as dyslipidemia, type 2 diabetes and cardiovascular diseases."( Ding, X; Fan, S; Feng, L; Gu, M; Guo, L; Huang, C; Jiang, D; Li, M; Li, Y; Tan, S; Xi, W; Zhang, Y; Zhou, Z, 2014)
"Obesity is a clinical syndrome which is driven by interactions between multiple genetic and environmental factors."( Hong, N; Hu, C; Jia, W; Liu, X; Tang, S; Wu, B; Yang, J; Zhao, Y, 2014)
"Obesity is associated with tissue-specific alterations in glucocorticoid metabolism, with increased activity of the glucocorticoid-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) in subcutaneous adipose tissue and decreased conversion of cortisone to cortisol, interpreted as decreased 11βHSD1 activity, in the liver."( Andrew, R; Olsson, T; Stomby, A; Walker, BR, 2014)
"Obesity is associated with a reduction of BAT function; however, it is unknown how obesity promotes dysfunctional BAT."( Aprahamian, T; Kikuchi, R; MacLauchlan, S; Maruyama, S; Papanicolaou, KN; Shimizu, A; Shimizu, I; Walsh, K, 2014)
"Obesity is well known to be linked to higher morbidity and mortality."( Akin, F; Dogu, H; Erurker, T; Topsakal, S; Yerlikaya, E, 2014)
"Obesity is associated with significant disturbance in the hormonal milieu that can affect the reproductive system."( Ayadi, H; Bahloul, A; Hadjkacem Loukil, L; Hadjkacem, H, 2015)
"Obesity is an independent risk factor for the development of kidney disease."( Arvapalli, R; Blough, E; Dai, X; Driscoll, H; Mahmood, M; Rice, KM; Wang, C; Wu, M, 2014)
"Obesity is a major health concern for adolescents, with one in four being overweight or obese in Australia."( Lewis, AJ; Millar, L; Moodie, M; Nicholls, L; Petersen, S; Swinburn, B, 2014)
"Obesity is a risk factor for breast cancer in postmenopausal women."( Berger, E; Bernard-Gallon, D; Billard, H; Caldefie-Chezet, F; Delort, L; Dubois, V; Geloen, A; Jardé, T; Vasson, MP, 2014)
"Childhood obesity is an increasing problem and is accompanied by metabolic disturbances."( Adamski, J; Grallert, H; Harder, U; Hellmuth, C; Illig, T; Knop, C; Koletzko, B; Lass, N; Peissner, W; Prehn, C; Reinehr, T; Wahl, S; Wang-Sattler, R; Wolters, B; Yu, Z, 2015)
"Presently, obesity is one of the major health problems in the developed as well as developing countries due to lack of physical work and increasing sedentary life style."( Giridhar, R; Kanhed, AM; Murumkar, PR; Sharma, MK; Yadav, MR, 2014)
"Although obesity is associated with gonadal dysfunction in the general population, gonadotoxic treatment might diminish the impact of obesity in childhood cancer survivors (CCS)."( Blijdorp, K; de Jong, FH; Laven, JS; Neggers, SJ; Pieters, R; Pluijm, SM; van den Heuvel-Eibrink, MM; van der Lely, AJ; van Dorp, W, 2014)
"Obesity is associated with gonadal dysfunction in male CCS, independent of the irreversible effect of previous cancer treatment."( Blijdorp, K; de Jong, FH; Laven, JS; Neggers, SJ; Pieters, R; Pluijm, SM; van den Heuvel-Eibrink, MM; van der Lely, AJ; van Dorp, W, 2014)
"Obesity is a known health risk for the development of several preventable diseases."( Bello, NT; Verpeut, JL, 2014)
"However, since obesity is known to induce leptin resistance, we hypothesize that resistance to the neuroprotective effects of leptin contributes to the pathogenesis of obesity-associated neurodegenerative diseases."( Davis, C; Hawkins, M; Mudd, J, 2014)
"Obesity is an independent risk factor associated with increasing serum creatinine levels in children aged more than 10 years."( Li, XM; Ma, YT; Xie, X; Yang, YN; Zheng, YY, 2014)
"Obesity is a major public health problem, predisposing subjects to metabolic syndrome, type 2 diabetes, and cardiovascular diseases."( Blanco Sequeiros, R; Herzig, KH; Hörkkö, S; Karsikas, S; Kivirikko, KI; Koivunen, P; Lammentausta, E; Mäkelä, KA; Myllyharju, J; Rahtu-Korpela, L; Serpi, R; Walkinshaw, G, 2014)
"Obesity is associated with metabolic dysfunction with sex differences and chronic, low-grade inflammation."( Cianflone, K; Lapointe, M; Marceau, P; Rezvani, R; Smith, J; Tchernof, A, 2014)
"Obesity is prevalent worldwide and associated with co-morbidities that result in increased cardiovascular risk."( Nimkevych, O; Uwaifo, GI; Varughese, AG, 2014)
"Obesity is characterized by dysfunctional white adipose tissue (WAT) that ultimately may lead to metabolic diseases."( Mariman, EC; Noben, JP; Renes, J; Rosenow, A; Roumans, N, 2014)
"Obesity is a risk factor leading to a number of chronic and metabolic disorders."( Akhtar, N; Bano, F; Ikram, H, 2014)
"Obesity is characterized by reciprocal alterations in FGF19 (decrease) and FGF21 (increase) levels."( Catalan, V; Domingo, P; Frühbeck, G; Gallego-Escuredo, JM; Giralt, M; Gómez-Ambrosi, J; Villarroya, F, 2015)
"Obesity is associated with several diseases including diabetes, nonalcoholic steatohepatitis (NASH), hypertension, cardiovascular disease, and cancer."( Baba, S; Hosoi, T; Ozawa, K, 2014)
"Obesity is a growing issue of the modern world, and its negative impact on bones in obese male patients has been recently reported."( Cha, PH; Choi, KY; Zahoor, M, 2014)
"Obesity is one of the major concerns in the world currently, its prejudicial effect is exerted by proteins secreted by adipose tissue, among them visfatin was demonstrated to be related with BMI and cardiovascular diseases."( Bosco, AA; Eleuterio, N; Petreanu, M; Sandrim, VC, 2014)
"Maternal obesity is associated with unfavorable outcomes, which may be reflected in the as yet undiscovered gene expression profiles of the umbilical cord (UC)."( Andres, A; Badger, TM; Faske, JB; Gomez-Acevedo, H; Lindsey, F; Lowery, CL; Saben, J; Shankar, K; Thakali, KM, 2014)
"Obesity is quickly becoming the leading preventable cause of death in the USA."( Ebbert, JO; Edakkanambeth Varayil, J; Hurt, RT, 2014)
"Obesity is considered to be accompanied by a chronic low-grade inflammatory state that contributes to the occurrence of many chronic diseases."( Feng, R; Li, S; Li, Y; Lin, S; Sun, C; Sun, X; Zhang, W, 2014)
"Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the development of insulin resistance (IR), metabolic syndrome and type 2 diabetes."( Contreras, C; Prieto, D; Sánchez, A, 2014)
"Although obesity is a major clinical risk factor for lymphedema, the mechanisms that regulate this effect remain unknown."( Albano, NJ; Cuzzone, DA; Gardenier, JC; Ghanta, S; Joseph, WJ; Mehrara, BJ; Savetsky, IL; Torrisi, JS, 2014)
"Although obesity is associated with high bone mass, recent reports suggest an increase in the incidence of fractures in obese patients."( Aguirre, L; Armamento-Villareal, R; Napoli, N; Qualls, C; Villareal, DT; Waters, D, 2014)
"Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has quickly become a worldwide pandemic with few tangible and safe treatment options."( Hill, BG; Sansbury, BE, 2014)
"Obesity is the most important risk factor for obstructive sleep apnea (OSA), and the effects of obesity may be mediated by tongue fat."( Brennick, MJ; Buxbaum, LU; Cater, JR; Delikatny, J; Kim, DY; Pack, AI; Pickup, S; Roscoe, I; Schwab, RJ; Shinde, S; Zhu, JX, 2014)
"Although abdominal obesity is closely associated with insulin resistance (hyperinsulinaemia), hyperleptinaemia and glucose dysfunction, changes in seminal plasma concentrations of insulin, leptin and glucose in obese males has not previously been investigated."( Bouic, PJ; Henkel, RR; Leisegang, K; Menkveld, R, 2014)
"Obesity is a growing epidemic and has been associated with an increased frequency of complications after various surgical procedures."( Alamanda, VK; Holt, GE; Moore, DC; Schwartz, HS; Song, Y, 2014)
"Obesity is a global epidemic with important healthcare and financial implications."( Ng, SY; Wilding, JP, 2014)
"Obesity is characterised by lipid accumulation in skeletal muscle, which increases the risk of developing insulin resistance and type 2 diabetes."( Azizi, PD; Chen, Z; Dyck, JR; Fullerton, MD; Galic, S; Hawke, TJ; Holloway, GP; Jorgensen, SB; Kemp, BE; Lally, JS; O'Neill, HM; Pulinilkunnil, T; Samaan, MC; Smith, BK; Steinberg, GR; Thomas, M; van Denderen, BJ, 2014)
"Obesity is identified as an important medical problem."( Nikonorov, AA; Skalnaya, MG; Skalny, AV; Tinkov, AA, 2015)
"Obesity is a major risk factor for the development of type 2 diabetes and other debilitating diseases."( Bornstein, SR; Chavakis, T; Eaton, S; Eisenhofer, G; Lamounier-Zepter, V; Mateska, I; Peitzsch, M; Swierczynska, MM, 2015)
"Obesity is known to lead to complications involving several systems."( Cayir, A; Cayir, Y; Ciftel, M; Kara, M; Kurt, N; Laloglu, E; Turan, MI; Yildirim, A, 2014)
"Overweight and obesity are increasing in individuals over age 60 years."( Anderson, PJ; Kuhle, CL; Murad, MH; Steffen, MW, 2014)
"Obesity is associated with poor outcomes in women with operable breast cancer."( Blackburn, GL; Findlay, B; Goodwin, PJ; Gralow, JR; Levine, M; Ligibel, JA; Mukherjee, S; Pond, GR; Pritchard, KI; Robidoux, A; Segal, RJ; Vallis, M, 2014)
"Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems."( Bonnefont-Rousselot, D, 2014)
"Obesity is characterized by high secretion of several cytokines from adipose tissue and is a recognized risk factor for many cancers."( Gong, H; Guo, S; Luo, C; Tian, Y; Zhou, W, 2014)
"Diabetes and obesity are diseases characterized by their increasing incidence every year."( Dębski, B; Goniewicz, M; Krzyżowska, M; Lewicka, A; Lewicki, S; Niemcewicz, M; Zdanowski, R, 2014)
"Breast cancer and obesity are associated with altered mRNA levels of cytokines and tumor marker in peripheral blood."( Al-Daghri, NM; Alenad, A; Alokail, MS; Mohammed, AK; Vanhoutte, P, 2014)
"It seems that obesity is an exacerbating factor for airway inflammation."( JalilMirmohammadi, S; Mehrparvar, AH; Safaei, S; Samimi, E; Torab Jahromi, M, 2014)
"Obesity is an effective factor in the inflammation of airways in patients with obstructive apnea."( JalilMirmohammadi, S; Mehrparvar, AH; Safaei, S; Samimi, E; Torab Jahromi, M, 2014)
"Obesity is a very common disease with very difficult treatment."( Matoulek, M; Stránská, Z; Sucharda, P; Svačina, S, 2014)
"Obesity is caused by a combination of both genetic and environmental risks."( Cai, L; Chen, J; Conklin, DJ; Jiang, X; Kim, KH; Kim, KS; Kim, YH; Tan, Y; Wang, J; Yan, X; Zhang, Z; Zheng, Y, 2014)
"Obesity is an important risk factor for the development of insulin resistance."( Abumrad, N; Arnold, AC; Biaggioni, I; Diedrich, A; Farley, G; Figueroa, RA; Gamboa, A; Okamoto, LE; Paranjape, SY; Raj, SR, 2014)
"Obesity is a major risk factor for metabolic syndrome, including insulin resistance (IR), type 2 diabetes mellitus (T2DM), and cardiovascular disease; ectopic fat deposition plays a key role in the development of these conditions."( Hu, P; Li, Q; Li, Z; Liu, F; Wang, C; Wang, H; Wu, J; Ye, J; Yuan, Y; Zhang, L, 2014)
"Obesity is considered as a major health problem."( Khazaei, M; Tahergorabi, Z, 2014)
"Obesity is associated with a risk of gastroesophageal reflux disease."( Belhocine, K; Bruley des Varannes, S; Flet, L; Touchefeu, Y; Vavasseur, F; Volteau, C, 2014)
"Obesity is a major epidemic in many parts of the world."( Levy, I; Manson, KF; Schiller, D; Zhang, Z, 2014)
"Obesity is associated with a state of chronic inflammation."( Badimon, L; Ferrer-Lorente, R; Tous, M, 2014)
"Obesity is often regarded as the primary cause of metabolic syndrome."( Chini, CC; Chini, EN; Escande, C; Kirkland, JL; Nin, V; Pirtskhalava, T; Tchkonia, T, 2015)
"Obesity is a risk factor for episodic migraine to develop into chronic migraine; hence, it is speculated that obesity and hyperleptinemia are associated with migraine."( Hamada, J; Kanazawa, N; Kitamura, E, 2015)
"The prevalence of obesity is increasing in industrialized countries."( Chung, D; Li, XM; Liang, B; Liu, C; Yang, N, 2014)
"Obesity is often attributed to a Western lifestyle, a high-fat diet and decreased activity."( Desai, M; Ross, MG, 2014)
"Obesity is a significant risk factor for the development of cardiovascular disease."( Beker, DL; Fillmore, N; Jaswal, JS; Keung, W; Lopaschuk, GD; Mori, J; Ussher, JR; Wagg, CS, 2014)
"Obesity is a public health problem and is increasing in all populations, including pregnant women."( Berezowski, AT; Brito, LG; Calderon, AC; Cavalli, RC; Duarte, G; Marcolin, AC; Quintana, SM, 2014)
"Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health."( Bonsel, GJ; de Vries, A; Reynolds, RM; Seckl, JR; van der Wal, M; Vrijkotte, TG, 2014)
"Notably, obesity is a modifiable determinant of arterial stiffness independent of high blood pressure, dyslipidemia and hyperglycemia in this population."( Lee, S; Lim, SC; Liu, JJ; Moh, AM; Ng, XW; Sum, CF; Tang, WE; Tavintharan, S; Yeoh, LY, 2014)
"Obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (COX-2) expression and activity in adipose-infiltrating macrophages."( Beeram, M; Bowers, LW; Brenner, AJ; deGraffenried, LA; Hursting, SD; Jolly, CA; Maximo, IX; Price, RS; Tekmal, RR, 2014)
"Human obesity is characterized by high levels of leptin, and leptin levels may change with weight loss and dietary restriction."( Aller, R; Conde, R; de la Fuente, B; de Luis, DA; Gonzalez Sagrado, M; Izaola, O; Primo, D, 2015)
"Obesity is associated with augmented peripheral inflammation and pain sensitivity in response to inflammatory stimulation, but the underlying mechanisms remain unclear."( Fu, Z; Li, D; Liang, L; Wang, J; Zhang, Q; Zhao, L, 2014)
"Obesity is not only a risk factor but also a marker of poor prognosis."( Bae-Jump, V; Stine, JE, 2014)
"Obesity is associated with blunted β-adrenoreceptor (β-AR)-mediated lipolysis and lipid oxidation in adipose tissue, but the mechanisms linking nutrient overload to catecholamine resistance are poorly understood."( Björnholm, M; Guo, T; Ibanez, CF; Marmol, P; Moliner, A; Shokat, KM; Zhang, C, 2014)
"Obesity is considered as a risk factor for mood disorders including depression."( Gertler, A; Jean, A; Papazoglou, IK; Taouis, M; Vacher, CM, 2015)
"Obesity is considered as an important public health problem in the world."( Hsiao, TJ; Lin, E, 2015)
"Obesity is currently considered a major public health problem in the world, already reaching epidemic characteristics, according to the World Health Organization."( Aikawa, P; Cintra, DE; Sartori-Cintra, AR, 2014)
"Obesity is a major risk factor for arterial hypertension, coronary artery disease, dyslipidemias, and type 2 diabetes."( Adamczyk, P; Fioravanti, A; Giannitti, C; Pascarelli, NA; Ponikowska, I; Tołodziecki, M; Urso, R, 2015)
"Obesity is a metabolic disorder that can lead to high blood pressure, increased blood cholesterol and triglycerides, insulin resistance, and diabetes mellitus."( Ma, C; Naqvi, S; Shamsi, BH; Xiao, Y, 2014)
"Obesity is associated with diminished GH secretion, which may result in the overdiagnosis of adult GH deficiency (GHD) in overweight/obese pituitary patients."( Biller, BM; Bredella, MA; Dichtel, LE; Gerweck, AV; Gurel, MH; Miller, KK; Riccio, AD; Russell, BM; Sluss, PM; Yuen, KC, 2014)
"Obesity is associated with cardiometabolic disease, including insulin resistance (IR) and diabetes."( Arora, P; Buys, ES; Dhakal, BP; Florez, JC; Ghorbani, A; Guanaga, DP; Ho, JE; Lewis, GD; Nathan, DI; Newton-Cheh, C; Walford, GA; Wang, TJ, 2014)
"Obesity is one of the greatest health threats facing the world today."( Bloom, SR; Scott, RV; Tan, TM, 2014)
"Obesity is a major correlate of cardiovascular disease."( Cunningham, JW; Wiviott, SD, 2014)
"Obesity is now a worldwide epidemic disease and poses a major risk for diet related diseases like type 2 diabetes, cardiovascular disease, stroke and fatty liver among others."( Chatterjee, S; Kumar, D; Negi, SK; Rao, KV; Sharma, S; Sinha, N; Tikoo, K; Tripathi, P, 2014)
"Obesity is associated with an alteration in zinc metabolism."( Chung, J; Kim, J; Noh, H; Paik, HY, 2014)
"Obesity is a global epidemic and a common risk factor for endothelial dysfunction and the subsequent development of diabetes mellitus and vascular diseases such as hypertension."( Abraham, NG; Favero, G; Lee, C; Rezzani, R; Schwartzman, ML; Silvis, AM; Sodhi, K; Vanella, L; Zeldin, DC, 2014)
"Obesity is associated with metabolic perturbations including liver and adipose tissue inflammation, insulin resistance, and type 2 diabetes."( Chen, M; Cherñavsky, AC; Feldstein, AE; Inzaugarat, ME; Lazic, M; Miller, YI; Nalbandian, M; Povero, D; Sears, DD; Zhao, IC, 2014)
"Obesity is known to be associated with many diseases in the long and short terms."( Çayır, A; Gurbuz, F; Kurt, N; Turan, Mİ; Yildirim, A, 2015)
"Overweight and obesity are common in the Netherlands: in 2006 51% of adult men and 42% of adult women were overweight; 10% of men and 12% of women were obese."( Brouwer, IA; Govers, E; Seidell, JC; Visser, M, 2014)
"Obesity is now a worldwide health problem."( Fukuoka, D; Hashizume, K; Okahara, F; Osaki, N; Shimotoyodome, A; Yanagawa, K, 2014)
"Obesity is an emerging disease worldwide."( Albert, L; Caixàs, A; Capel, I; Rigla, M, 2014)
"Obesity is the leading preventable comorbidity associated with increased prostate cancer-related recurrence and mortality."( Apte, SA; Bowers, LW; Cavazos, DA; deGraffenried, LA; deGraffenried, MJ; Whelan, KA, 2014)
"Obesity is a modern pandemic with continuous expansion and represents an independent risk factor for non-alcoholic fatty liver disease (NAFLD), the most common liver disease in westernized countries."( Baba, HA; Bechmann, LP; Canbay, A; Claudel, T; Feldstein, AE; Gerken, G; Köfeler, H; Scharnagl, H; Schlattjan, M; Sowa, JP; Stojakovic, T; Trauner, M; Wree, A, 2014)
"Obesity is a growing health problem worldwide."( Blaut, M; Klaus, S; Loh, G; Pfeiffer, N; Woting, A, 2014)
"Obesity is a global problem and in aspects of lethal ethanol intoxications virtually unexplored."( Ottosson, A; Wingren, CJ, 2014)
"Obesity is associated with endothelial dysfunction and impaired relaxation, although how obesity influences endothelial SK3/IK1 function is unclear."( Climent, B; Contreras, C; García-Sacristán, A; Martínez, P; Moreno, L; Pérez-Vizcaíno, F; Prieto, D; Rivera, L; Sánchez, A, 2014)
"Obesity is associated with an increased risk of osteoarthritis (OA) of the knee."( Fowler-Brown, A; Kim, DH; Leveille, S; Marcantonio, E; Shi, L; Shmerling, RH; Wee, CC, 2015)
"Over-weight and obesity are serious problems that increase the risk not only for chronic diseases like diabetes and heart disease but also of various types of cancer."( Arıbas, S; Bayram, F; Bitgen, N; Diri, H; Donmez-Altuntas, H; Guclu, K; Gundogan, K; Hamurcu, Z; Mert, M; Sahin, F, 2014)
"We conclude that obesity is associated with overproduction of procoagulant MP and increase TG."( Campello, E; Fadin, M; Gavasso, S; Radu, CM; Simioni, P; Spiezia, L; Vettor, R; Woodhams, B; Zabeo, E, 2015)
"Importantly, obesity is also highly associated with elevated cholesterol, and cholesterol itself is a risk factor for breast cancer."( Chang, CY; McDonnell, DP; Nelson, ER, 2014)
"Obesity is critically important to maternal and fetal health during the perinatal period."( Avcı, A; Avcı, ME; Çelik, M; Göçmen, A; Kocaer, M; Şanlıkan, F, 2015)
"We conclude that obesity is an important factor associated with pregnancy complications and the increase in maternal-fetal morbidity and mortality."( Avcı, A; Avcı, ME; Çelik, M; Göçmen, A; Kocaer, M; Şanlıkan, F, 2015)
"The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women."( Chen, XC; Fu, YC; Liu, WJ; Luo, LL; Ni, YH; Xu, JJ; Zhang, HX; Zhang, XM; Zhou, XL, 2014)
"Maternal obesity is associated with the development of obesity, hypertension and hypercholesterolaemia in adulthood, suggesting that the risk for AD and CAA may also be influenced by the early-life environment."( Carare, RO; Gentleman, SM; Hawkes, CA; Nicoll, JA, 2015)
"Obesity is a common and complex health problem, which impacts crucial organs; it is also considered an independent risk factor for chronic kidney disease."( Favero, G; Giugno, L; Lavazza, A; Reiter, RJ; Rezzani, R; Rodella, LF; Stacchiotti, A, 2014)
"Obesity is defined by excessive accumulation of body fat relative to lean tissue."( Campos, DH; Cicogna, AC; Leopoldo, AS; Lima-Leopoldo, AP; Nascimento, AF; Oliveira-Junior, SA; Padovani, CR; Silva, DC; Sugizaki, MM, 2014)
"Overeating and obesity are associated with impulsivity."( Bongers, P; Booij, J; Jansen, A; Nederkoorn, C; Roefs, A; van de Giessen, E; van den Brink, W, 2015)
"Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities."( Arble, DM; Sandoval, DA; Seeley, RJ, 2015)
"Obesity is one of the major public health problems worldwide and it is generally associated with many diseases."( Ismail, Z; Karupiah, S, 2015)
"Visceral obesity is more common in the Arab population and more closely related to morbidity, including diabetes and related cardiovascular diseases (CVD)."( El Essa, A; Gariballa, S; Kosanovic, M; Yasin, J, 2014)
"Obesity is a risk factor for preeclampsia, but the reason for this risk is unknown."( Shukla, J; Walsh, SW, 2015)
"Obesity is defined as an abnormal increase in white adipose tissue and has become a major medical burden worldwide."( Aime, S; Bauer, M; Beretta, M; Braccini, L; Carnevale, D; Ghigo, A; Hirsch, E; Iacobucci, R; Kilić, A; Lembo, G; Liebig-Gonglach, M; Longo, D; Mongillo, M; Perino, A; Pfeifer, A; Repetto, IE; Vercelli, A; Wetzker, R; Zaglia, T, 2014)
"Obesity is a serious medical problem worldwide."( Chang, B; Chen, XY; Kong, Y; Lian, FM; Liu, HF; Sun, X; Tong, XL; Xie, WQ; Xu, Y; Zhang, LL; Zhen, Z; Zhou, LB; Zhou, Q; Zhou, SP; Zhou, Y, 2014)
"Obesity is a disease which has become more prevalent in Romania."( Iordache, N; Iorgulescu, A; Turcu, F, 2014)
"Obesity is now a major international health concern."( Boyle, J; De Courten, B; Joham, A; Naderpoor, N; Shorakae, S; Teede, HJ, 2015)
"Obesity is considered as a chronic disease that can induce a series of comorbidities and complications."( Jiang, JG; Zhang, WL; Zhu, L, 2014)
"Obesity is associated with enhanced inflammation and mental stress, but limited information has addressed the potential additive effect of psychological stress on obesity-associated inflammation."( Acevedo, EO; Huang, CJ; Shibata, Y; Slusher, AL; Stewart, JK, 2015)
"Obesity is associated with increased cardiovascular morbidity and mortality, inflammation, and elevated cortisol levels."( Bandinelli, S; Ferrucci, L; Gemma, A; Incalzi, RA; Laudisio, A, 2015)
"Obesity is a national epidemic that imposes direct medical and indirect economic costs on society."( Squalli, J, 2014)
"Additionally, since obesity is associated with increased offspring birth defect incidence, we hypothesized that a DMBA-induced DNA damage response (DDR) is compromised in ovaries from obese females."( Ganesan, S; Keating, AF; Nteeba, J, 2014)
"Obesity is often related to steeper temporal discounting, that is, higher decision impulsivity for immediate rewards over delayed rewards."( Bruce, AS; Lim, SL, 2015)
"Maternal obesity is associated with adverse perinatal outcome."( Doshani, A; Jeve, YB; Konje, JC, 2015)
"Obesity is a major risk factor for asthma."( Leiria, LO; Martins, MA; Saad, MJ, 2015)
"The prevalence of obesity is rapidly increasing across the world."( Bártíková, H; Boušová, I; Levorová, L; Matoušková, P; Skálová, L; Szotáková, B, 2015)
"Obesity is associated with a worse breast cancer prognosis, particularly in estrogen receptor alpha (ERα) positive, postmenopausal patients."( Bowers, LW; Brenner, AJ; deGraffenried, LA; Hursting, SD; Tekmal, RR, 2015)
"Obesity is associated with chronic inflammation in multiple tissues, and hepatic inflammation is mechanistically linked to both steatosis and hepatic insulin resistance."( Bui, Q; Chakrabarty, S; Ruf, W; Samad, F; Wang, J, 2015)
"Obesity is associated with a cluster of metabolic disorders, low-grade inflammation and altered gut microbiota."( Bäckhed, F; Bindels, LB; Caesar, R; Cani, PD; Castel, J; Cochez, P; Delzenne, NM; Denis, RG; Dumoutier, L; Duparc, T; Everard, A; Geurts, L; Luquet, S; Matamoros, S; Muccioli, GG; Pierard, F; Plovier, H; Renauld, JC; Robine, S; Van Hul, M, 2014)
"Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases."( Allen, AM; Bassi, J; Brown, RD; Cowley, MA; Dileone, R; Elmquist, JK; Enriori, PJ; Farooqi, IS; Greenway, FL; Grove, KL; Henning, E; Keogh, JM; Licinio, J; Myers, MG; O'Rahilly, S; Pryor, JT; Ravussin, E; Simonds, SE; Spanswick, DC; Sternson, SM, 2014)
"Rates of obesity are higher among more dependent smokers and 37%-65% of smokers seeking cessation treatment are overweight or obese."( Aveyard, P; David, SP; Johnstone, EC; Munafò, MR; Murphy, MF; Strong, DR, 2015)
"Obesity is a known risk factor for breast cancer."( Alshaker, H; Blyuss, O; Frampton, AE; Krell, J; Pchejetski, D; Stebbing, J; Waxman, J; Winkler, M; Yagüe, E; Zaikin, A, 2014)
"Obesity is prevalent worldwide, and is highly associated with metabolic disorders, such as insulin resistance, hyperlipidemia and steatosis."( Cai, W; Fan, S; Feng, L; Huang, C; Ji, G; Yu, L; Zhang, Y, 2014)
"Overweight and obesity are common in patients with bipolar disorder."( Bengesser, SA; Birner, A; Kapfhammer, HP; Lackner, N; Reininghaus, B; Reininghaus, E, 2014)
"Obesity is a chronic disease that represents one of the most serious global health burdens associated to an excess of body fat resulting from an imbalance between energy intake and expenditure, which is regulated by environmental and genetic interactions."( Barrenetxe, J; Martínez, JA; Moreno-Aliaga, MJ; Sáinz, N, 2015)
"Although obesity is prevalent worldwide, few studies have investigated how obesity interacts with folate status."( Bird, JK; Choi, SW; Du, F; Liu, Z; Mason, JB; Ronnenberg, AG, 2015)
"In summary, obesity is associated with decreased serum folate, which parallels decreased folate intakes."( Bird, JK; Choi, SW; Du, F; Liu, Z; Mason, JB; Ronnenberg, AG, 2015)
"Obesity is an increasingly prevalent disease regulated by genetic and environmental factors."( Artis, D; Brestoff, JR; Farber, DL; Kim, BS; Lutfy, K; Monticelli, LA; Saenz, SA; Seale, P; Sonnenberg, GF; Stine, RR; Thome, JJ, 2015)
"Overweight and obesity are major risk factors for the development of nonalcoholic fatty liver disease (NAFLD)."( Akyuz, U; Yesil, A; Yilmaz, Y, 2015)
"Childhood obesity is related to low physical activity level and a sedentary lifestyle."( Deurenberg, P; Ismail, MN; Lee, ST; Poh, BK; Shanita, SN; Wong, JE, 2014)
"Obesity is a cardiovascular risk factor, but the obesity paradox in patients undergoing percutaneous coronary intervention is poorly understood."( Brodie, BR; Duffy, PL; Kang, SJ; Kirtane, AJ; Maehara, A; Metzger, DC; Mintz, GS; Rinaldi, MJ; Shimizu, T; Stone, GW; Stuckey, TD; Weisz, G; Witzenbichler, B; Xu, K, 2015)
"Obesity is associated with increased risked factor for many diseases such as, diabetes, heart complications, arthritis and certain types of cancer."( Ahmed, A; Ahmed, M; Bano, F; Parveen, T, 2015)
"Obesity is often associated with an alter lipid profile, e."( Avan, A; Emamian, M; Ferns, GA; Ghayour-Mobarhan, M; Mirhafez, SR; Moghadam, MS; Parizadeh, SM; Pasdar, A; Sadeghzadeh, M, 2015)
"Global levels of obesity are reaching epidemic proportions, leading to a dramatic increase in incidence of secondary diseases and the significant economic burden associated with their treatment."( Aguilar-Valles, A; Inoue, W; Luheshi, GN; Rummel, C, 2015)
"Obesity is a leading modifiable risk factor for the development of several epithelial malignancies."( Dannenberg, AJ; Hudis, CA; Iyengar, NM, 2015)
"Obesity is a recognised positive risk factor for colorectal adenoma and colorectal cancer."( Cross, AJ; Gunter, MJ; Hayes, R; Huang, WY; Murphy, N; Rajabzadeh-Heshejin, V; Stanczyk, F, 2015)
"Obesity is an important worldwide public health problem and considered a disease of chronic low-grade inflammation."( Jafari, A; Karimi, M; Rafraf, M, 2015)
"Obesity is thought to be highly prevalent in persons with lower extremity amputations (LEAs) and can impair physical and social functioning."( Arterburn, DE; Bouldin, ED; Boyko, EJ; Littman, AJ; Majerczyk, BR; McFarland, LV; Thompson, ML, 2015)
"Obesity is associated with decreased iron status, possibly due to a rise in hepcidin, an inflammatory protein known to reduce iron absorption."( Campoy, C; Florido, J; Garcia-Valdes, L; Hayes, H; McArdle, HJ; Miranda, MT; Rusanova, I, 2015)
"Obesity is a major cause for a spectrum of metabolic syndrome-related diseases that include insulin resistance, type 2 diabetes, and steatosis of the liver."( Ruf, W; Samad, F, 2015)
"Obesity is associated with insulin resistance and is known to be a risk factor for type-2 diabetes."( Alonso-Magdalena, P; Boschero, AC; Carneiro, EM; Irles, E; Lluesma, M; Nadal, Á; Ñeco, P; Quesada, I; Santos-Silva, JC; Vettorazzi, JF; Villar-Pazos, S, 2015)
"Obesity is a risk factor for postmenopausal breast cancer and the majority of these cancers are estrogen dependent."( Brown, KA; Docanto, MM; Lo, C; Sasano, H; Simpson, ER; Wang, X, 2015)
"Obesity is a growing epidemic and a major contributor to the global burden of disease."( Dahiya, N; Kakkar, AK, 2015)
"Obesity is an important risk factor in the development of acute mountain sickness."( Cao, F; Li, CW; Sun, ZJ; Yang, B; Zhang, J; Zhao, H, 2015)
"Obesity is among the most pressing health concerns in the world since it is increasingly common even in the developing world, and is clearly associated with increased risk for chronic debilitating diseases and death."( Madan, R; Petri, WA, 2015)
"Obesity is a known risk factor for infertility in women."( Bahadursingh, S; Ramsewak, S; Sharma, A; Teelucksingh, S, 2015)
"Obesity is a major health burden with an increased risk of cardiovascular morbidity and mortality."( Adya, R; Randeva, HS; Tan, BK, 2015)
"Obesity is a known risk factor for allergic asthma."( Kim, JY; Lee, JH; Park, JW; Sohn, JH, 2015)
"Obesity is a worldwide health problem that urgently needs to be solved."( Hasegawa, Y; Hosoi, T; Matsuzaki, S; Miyahara, T; Ozawa, K; Shimizu, K, 2015)
"Obesity is a major risk factor for several cancers, including female cancers."( Biessy, C; de la Luz Hernandez, M; Lajous, M; Lopez-Ridaura, R; Ortiz-Panozo, E; Rinaldi, S; Romieu, I; Torres-Mejia, G; Yunes, E, 2015)
"Obesity is a multifactorial disorder involving an abnormal or excessive amount of body fat."( Arola, L; Bladé, C; Casanova, E; Fernández-Iglesias, A; Salvadó, MJ, 2015)
"Obesity is connected with higher resting systolicBP and modifies the HRV response to mental stress."( Cizmarova, E; Garafova, A; Jezova, D; Marko, A; Penesova, A; Vlcek, M, 2014)
"Obesity is heritable and predisposes to many diseases."( Abecasis, GR; Absher, D; Adair, LS; Albrecht, E; Amin, N; Amouyel, P; Anderson, D; Ärnlöv, J; Arscott, GM; Arveiler, D; Asselbergs, FW; Assimes, TL; Attwood, AP; Bakker, SJL; Bandinelli, S; Barrett, A; Barroso, I; Bas, IN; Beckmann, JS; Beekman, M; Beilby, J; Bellis, C; Bennett, AJ; Bergman, RN; Berndt, SI; Berne, C; Blagieva, R; Blangero, J; Blüher, M; Bochud, M; Boehm, BO; Boehnke, M; Boerwinkle, E; Böhringer, S; Bolton, JL; Bonnycastle, LL; Borecki, IB; Bornstein, SR; Böttcher, Y; Bottinger, EP; Bouchard, C; Bovet, P; Boyd, HA; Bragg-Gresham, JL; Brennan, EP; Bruinenberg, M; Buchkovich, ML; Buyske, S; Campbell, H; Caspersen, IH; Cauchi, S; Caulfield, MJ; Cesana, G; Chakravarti, A; Chambers, JC; Chanock, SJ; Chasman, DI; Chen, J; Chen, YI; Chines, PS; Choi, M; Clarke, R; Collins, FS; Cooper, RS; Crawford, DC; Croteau-Chonka, DC; Cupples, LA; Cusi, D; Danesh, J; Dastani, Z; Daw, EW; Day, FR; de Bakker, PIW; de Craen, AJM; de Faire, U; Dedoussis, G; Delgado, G; Deloukas, P; Demirkan, A; den Ruijter, HM; Deng, G; Dimitriou, M; Dominiczak, AF; Doney, ASF; Dorajoo, R; Drong, AW; Ehret, GB; Eklund, N; Erbel, R; Erdmann, J; Eriksson, JG; Eriksson, P; Esko, T; Estrada, K; Eury, E; Fall, T; Farrall, M; Faul, JD; Feenstra, B; Fehrmann, R; Feitosa, MF; Felix, SB; Ferrannini, E; Ferreira, T; Ferrières, J; Ferrucci, L; Fischer, K; Folkersen, L; Ford, I; Forouhi, NG; Forrester, T; Fox, CS; Franco, OH; Franco-Cereceda, A; Franke, L; Franks, PW; Fraser, RM; Frayling, TM; Froguel, P; Gådin, JR; Gansevoort, RT; Garcia, ME; Gejman, PV; Geller, F; Gharavi, AG; Giedraitis, V; Gieger, C; Gigante, B; Go, AS; Goddard, ME; Goel, A; Golay, A; Gong, J; Goodall, AH; Gordon, SD; Gorski, M; Gottesman, O; Grabe, HJ; Grallert, H; Grammer, TB; Gräßler, J; Grönberg, H; Groop, LC; Groves, CJ; Gudnason, V; Gustafsson, S; Gusto, G; Gyllensten, U; Haessler, J; Haiman, CA; Hall, AS; Hall, P; Haller, T; Hallmans, G; Hamsten, A; Handsaker, RE; Harris, TB; Hartman, CA; Hassinen, M; Hattersley, AT; Hayward, C; Heard-Costa, NL; Heath, AC; Hedman, ÅK; Heid, IM; Helmer, Q; Hengstenberg, C; Hicks, AA; Hindorff, LA; Hingorani, AD; Hirschhorn, JN; Hofman, A; Holmen, O; Homuth, G; Hottenga, JJ; Hovingh, GK; Huang, J; Hui, J; Humphries, SE; Hunt, SC; Hunter, DJ; Hveem, K; Hyppönen, E; Illig, T; Ingelsson, E; Isaacs, A; Jackson, AU; Jacobs, KB; James, AL; Jarvelin, MR; Jeff, JM; Jöckel, KH; Johansen, B; Johansson, Å; Jolley, J; Jousilahti, P; Jukema, JW; Jula, AM; Juliusdottir, T; Justice, AE; Kahali, B; Kanoni, S; Kaplan, RC; Kaprio, J; Karjalainen, J; Karpe, F; Kastelein, JJP; Kathiresan, S; Keildson, S; Keinanen-Kiukaanniemi, SM; Kiemeney, LA; Kinnunen, L; Kiryluk, K; Kivimaki, M; Kleber, ME; Knekt, P; Koenig, W; Kooner, JS; Kooperberg, C; Koskenvuo, M; Kovacs, P; Kraja, AT; Kratzer, W; Kristiansson, K; Kubo, M; Kuh, D; Kumari, M; Kutalik, Z; Kuusisto, J; Laakso, M; Laitinen, J; Lakka, TA; Lamina, C; Langenberg, C; Leach, IM; Leander, K; Lee, JY; Lee, NR; Lehtimäki, T; Liang, L; Lichtner, P; Lifton, RP; Lim, U; Lind, L; Lindgren, CM; Lindström, J; Liu, Y; Lo, KS; Lobbens, S; Locke, AE; Loos, RJF; Lorbeer, R; Lotay, V; Lu, Y; Luan, J; Lyssenko, V; Ma, B; Mach, F; Madden, PAF; Mägi, R; Magnusson, PKE; Mahajan, A; Mangino, M; Männistö, S; Marchand, LL; Marette, A; Martin, NG; März, W; Matise, TC; McArdle, WL; McCarroll, SA; McCarthy, MI; McKenzie, CA; McKnight, AJ; McKnight, B; McLachlan, S; Medina-Gomez, C; Medland, SE; Melbye, M; Menni, C; Merger, S; Metspalu, A; Mihailov, E; Milani, L; Min, JL; Moayyeri, A; Moebus, S; Moffatt, MF; Mohlke, KL; Moll, FL; Monda, KL; Montgomery, GW; Morken, MA; Morris, AD; Morris, AP; Mulas, A; Müller, G; Müller-Nurasyid, M; Munroe, PB; Murabito, JM; Murray, JC; Musk, AW; Nagaraja, R; Nalls, MA; Nelis, M; Nicholson, G; Njølstad, I; Nolte, IM; North, KE; Nöthen, MM; Nyholt, DR; O'Connell, JR; Ohlsson, C; Okada, Y; Oldehinkel, AJ; Ong, KK; Oostra, BA; Palmer, CD; Palmer, CNA; Pasko, D; Pasterkamp, G; Pechlivanis, S; Peden, JF; Pedersen, NL; Perola, M; Perry, JRB; Pers, TH; Pérusse, L; Peters, A; Peters, MJ; Peters, U; Pilz, S; Postma, DS; Powell, C; Power, C; Pramstaller, PP; Price, JF; Prokopenko, I; Qi, L; Quertermous, T; Raitakari, OT; Randall, JC; Rankinen, T; Rao, DC; Rauramaa, R; Rayner, NW; Reinmaa, E; Renstrom, F; Rettig, R; Rice, TK; Ridker, PM; Ried, JS; Rioux, JD; Ripke, S; Ritchie, MD; Rivadeneira, F; Robertson, NR; Rose, LM; Rudan, I; Saaristo, TE; Saleheen, D; Salem, RM; Salomaa, V; Samani, NJ; Sandholm, N; Sanna, S; Saramies, J; Sarzynski, MA; Sattar, N; Schadt, EE; Scharnagl, H; Scherag, A; Schlessinger, D; Schmidt, EM; Scholtens, S; Schumacher, FR; Schunkert, H; Schwarz, PEH; Scott, RA; Scott, WR; Seufferlein, T; Sever, P; Shi, J; Shuldiner, AR; Shungin, D; Sinisalo, J; Slagboom, PE; Smith, AV; Smith, JA; Smolonska, J; Snieder, H; Spector, TD; Speliotes, EK; Stančáková, A; Stanton, AV; Stefansson, K; Steinthorsdottir, V; Stirrups, K; Stolk, L; Stolk, RP; Strachan, DP; Strauch, K; Strawbridge, RJ; Stringham, HM; Stumvoll, M; Sundström, J; Sung, YJ; Swertz, MA; Swift, AJ; Syvänen, AC; Takahashi, A; Tan, ST; Tanaka, T; Tayo, BO; Teumer, A; Thorand, B; Thorleifsson, G; Thorsteinsdottir, U; Tönjes, A; Trégouët, DA; Tremblay, A; Tremoli, E; Trompet, S; Tuomilehto, J; Tyrer, JP; Uh, HW; Uitterlinden, AG; Uusitupa, M; van 't Hooft, FM; van der Harst, P; van der Laan, SW; van Duijn, CM; van Setten, J; Van Vliet-Ostaptchouk, JV; Vandenput, L; Vedantam, S; Verhulst, FC; Vermeulen, SH; Verweij, N; Vinkhuyzen, AAE; Virtamo, J; Visscher, PM; Vohl, MC; Völker, U; Vonk, JM; Waeber, G; Waite, LL; Walker, M; Wallaschofski, H; Wang, Z; Wareham, NJ; Warren, HR; Waterworth, D; Watkins, H; Weedon, MN; Weir, DR; Westra, HJ; Wichmann, HE; Wilkens, LR; Willemsen, G; Willenborg, C; Willer, CJ; Wilsgaard, T; Wilson, JF; Winkler, TW; Witteman, JC; Wojczynski, MK; Wong, A; Wood, AR; Workalemahu, T; Wright, AF; Yang, J; Yengo, L; Zanen, P; Zhang, Q; Zhang, W; Zhao, JH; Zhao, W; Zheng, W; Zillikens, MC; Zondervan, KT, 2015)
"Obesity is considered a subchronic inflammatory disease with high risk of comorbidity development."( Andrade, VL; Béla, SR; de Assis Martins-Filho, O; de Moraes, TF; Fernandes, KS; Sandrim, VC, 2015)
"Obesity is a metabolic and hormonal disorder with serious social and psychological impacts."( Andreazzi, AE; de Caires Júnior, LC; de Freitas Mathias, PC; Gonçalves, CF; González Garcia, RM; Guimarães, ED; Macedo de Almeida, M; Mourao-Júnior, CA; Musso, CM; Paes, ST; Pettersen, KG; Torrezan, R, 2017)
"Obesity is an alarming threat for all age groups, including children."( Daoudi, H; Khan, NA; Plesnik, J; Rouabah, A; Rouabah, L; Sayed, A; Šerý, O, 2015)
"Obesity is a multi-factorial disorder which is of worldwide concern."( Baghdad, CH; Belarbi, M; Benammar, CH; Sari, N; Sour, S; Visioli, F, 2015)
"Obesity is a growing problem in India, the dietary determinants of which have been studied using an 'individual food/nutrient' approach."( Ben-Shlomo, Y; Bharathi, AV; Bowen, L; Davey Smith, G; Ebrahim, S; Hu, FB; Kinra, S; Prabhakaran, D; Reddy, KS; Satija, A; Vaz, M, 2015)
"Obesity is the result of a positive energy balance and often leads to difficulties in maintaining normal postprandial metabolism."( Feng, R; Guo, F; Jiao, J; Li, Y; Liu, L; Sun, C, 2015)
"Obesity is associated with increased colonic inflammation, which elevates the risk of colon cancer."( Dai, C; Gu, SZ; Liu, WX; Sang, LX; Wang, HL; Wang, T; Wang, Y; Xing, JW; Zhang, S; Zhou, F, 2015)
"Obesity is usually associated with hyperleptinaemia and resistance to anorectic and body weight-reducing effects of leptin."( Anamthathmakula, P; Sahu, A; Sahu, M, 2015)
"Obesity is a risk factor for decline in glomerular filtration rate (GFR)."( Ferrucci, L; Incalzi, RA; Patel, KV; Pedone, C; Roshanravan, B; Scarlata, S, 2015)
"In animal studies obesity is associated with higher blood and tissue mercury concentrations; however human studies are lacking."( Fayad, R; Korrick, SA; Rothenberg, SE, 2015)
"Obesity is one of the most serious global health problems, which increases the risk of other different chronic diseases."( Daglia, M; Nabavi, SF; Nabavi, SM; Russo, GL, 2015)
"Obesity is a major risk factor for many chronic metabolic diseases such as inflammation, insulin resistance (IR) and fatty liver injury."( Kayan-Tapan, T; Koçak, H; Öner-İyidoğan, Y; Seyithanoğlu, M; Tanrikulu-Küçük, S; Topparmak, E, 2015)
"Obesity is increasing in developed as well as in developing countries."( Asrin, M; Das, RK; Hasan, MI; Nessa, A, 2015)
"Obesity is accompanied by an increase in the size and the number of adipocytes."( Cooper, GJ; Ding, S; Gao, X; Han, W; Hui, X; Li, K; Li, P; Liu, P; Mao, L; Nie, B; Nie, T; Tang, X; Wu, D; Xu, A; Yuan, R, 2015)
"Obesity is associated with an overexpansion of adipose tissue, along with increases in blood pressure, glycemia, inflammation, and thrombosis."( Kalupahana, NS; LeMieux, MJ; Moustaid-Moussa, N; Scoggin, S, 2015)
"Obesity is a known risk factor for cardiometabolic disease."( Ceaser, T; Hunter, G, 2015)
"Obesity is associated with poor asthma control, increased asthma morbidity, and decreased response to inhaled corticosteroids."( Avila, PC; Bibbins-Domingo, K; Borrell, LN; Brigino-Buenaventura, E; Burchard, EG; Castellanos, E; Davis, A; Eng, C; Farber, HJ; Kumar, R; LeNoir, MA; McGarry, ME; Meade, K; Oh, SS; Rodriguez-Cintron, W; Rodriguez-Santana, JR; Sen, S; Serebrisky, D; Thakur, N; Thyne, SM, 2015)
"Obesity is associated with bronchodilator unresponsiveness among black and Latino children and adolescents with asthma."( Avila, PC; Bibbins-Domingo, K; Borrell, LN; Brigino-Buenaventura, E; Burchard, EG; Castellanos, E; Davis, A; Eng, C; Farber, HJ; Kumar, R; LeNoir, MA; McGarry, ME; Meade, K; Oh, SS; Rodriguez-Cintron, W; Rodriguez-Santana, JR; Sen, S; Serebrisky, D; Thakur, N; Thyne, SM, 2015)
"Obesity is associated with an increased risk of CKD in a national sample of the UK population, even after adjustment for known CKD risk factors, which may have implications for CKD screening and future national health service planning and delivery."( Hall, WL; Macdougall, IC; MacLaughlin, HL; Sanders, TA, 2015)
"Obesity is associated with abnormal brain reactivity in response to palatable food consumption, a factor that may contribute to non-homeostatic eating."( Beloate, LN; Freeman, KB; Huskinson, SL; Roma, PG; Townsend, EA, 2015)
"Diet-induced obesity is associated to an imbalance in the normal gut microbiota composition."( Arias, N; Boqué, N; Etxeberria, U; Macarulla, MT; Martínez, JA; Milagro, FI; Portillo, MP, 2015)
"Obesity is becoming the new pediatric epidemic."( Fanter, R; Frey, MR; Hilbush, B; Lin, M; Michail, S; Paliy, O; Reo, NV, 2015)
"Obesity is associated with a greater incidence of musculoskeletal disease, particularly osteoarthritis of the weight-bearing joints, including the ankle."( Burrus, MT; Cooper, MT; Looney, AM; Park, JS; Perumal, V; Werner, BC, 2015)
"Obesity is also associated with an increased risk of cancer recurrence and mortality most likely due to suboptimal treatment and/or co-morbidities."( Benedetto, C; Canuto, EM; Gennarelli, G; Salvagno, F, 2015)
"In conclusion, obesity is marked by alterations in functional connectivity networks involved in food reward and salience."( Pijl, H; Rombouts, SA; van Buchem, MA; van der Grond, J; Veer, IM; Wijngaarden, MA; Willems van Dijk, K, 2015)
"Obesity is increasing worldwide, and high-protein (HP) diets are widely used for weight loss."( Aukema, HM; Caligiuri, SP; Devassy, JG; House, JD; Ibrahim, NH; Mayengbam, S; Taylor, CG; Zahradka, P, 2015)
"Obesity is strongly associated with the cause of structural and functional changes of the heart in both human and animal models."( Li, X; Liang, D; Liang, G; Qian, Y; Skibba, M; Wei, T; Wu, L; Xu, Z; Zeng, C; Zhong, P, 2015)
"Obesity is associated with a higher risk of metabolic and cardiovascular diseases, cancer, and other clinical conditions."( Murakami, S, 2015)
"Obesity is a central health issue due to its epidemic prevalence and its association with type 2 diabetes and other comorbidities."( Abdali, D; Grover, AK; Samson, SE, 2015)
"Although obesity is known to increase CVD risks, its impact on the heart on estrogen deprivation is still inconclusive."( Chattipakorn, N; Chattipakorn, SC; Kumfu, S; Pratchayasakul, W; Sa-Nguanmoo, P; Sivasinprasasn, S, 2015)
"Obesity is a risk factor for ischemic necrosis of the femoral head (INFH)."( Jang, KY; Kim, JR; Kim, KM; Lee, KB; Moon, YJ; Park, BH; Wagle, S; Zhou, L, 2015)
"Development of obesity is associated with angiogenesis and inflammation, and increased ADAMTS13 synthesis in the liver."( Geys, L; Lijnen, HR; Roose, E; Scroyen, I; Vanhoorelbeke, K, 2015)
"Most forms of human obesity are characterized by impaired leptin sensitivity and, therefore, the effectiveness of anti-obesity leptin therapy in these leptin-resistant obese patients is marginal."( Elmquist, JK; Fukuda, M; Hinton, AO; Saito, K; Tong, Q; Wang, C; Wu, Q; Xu, P; Xu, Y; Yan, C; Yan, X; Yang, Y, 2015)
"Obesity is associated with chronic low-grade inflammation."( Brown, KA; Corbould, A; Docanto, MM; Ham, S, 2015)
"Obesity is related to vascular dysfunction through inflammation and oxidative stress and it has been identified as a risk factor for chronic renal disease."( Benedito, S; García-Sacristán, A; Hernández, M; López-Oliva, ME; Muñoz, M; Pilar Martínez, M; Prieto, D; Sánchez, A, 2015)
"Obesity is associated with cancer risk in esophageal adenocarcinoma (EAC)."( Alfieri, R; Cagol, M; Calabrese, F; Carraro, A; Castoro, C; Kotsafti, A; Lunardi, F; Porzionato, A; Saadeh, L; Scarpa, M; Tedeschi, U; Trevellin, E; Vettor, R, 2015)
"As obesity is frequently associated with type 2 diabetes, we investigated whether 26RFa may be involved in the regulation of glucose homeostasis."( Alexandre, D; Anouar, Y; Arabo, A; Berrahmoune, H; Bonner, C; Chartrel, N; Chigr, F; Coëffier, M; Déchelotte, P; El Ouahli, M; Gobet, F; Jeandel, L; Kerr-Conte, J; Lefebvre, H; Leprince, J; Malagon, M; Picot, M; Prévost, G, 2015)
"Obesity is a known risk factor for various metabolic disorders and cardiovascular diseases."( Ali, Q; Hussain, T; Khan, MA; Nag, S; Samuel, P, 2015)
"Obesity is an established risk factor for postmenopausal breast cancer."( Monk, JM; Mourtzakis, M; Robinson, LE; Schmidt, S, 2015)
"Obesity is a significant risk factor for the development of different cancer types and has been associated with poorer response to oncotherapies and linked to earlier recurrence of the neoplastic disease."( Otvos, L; Surmacz, E, 2015)
"Obesity is a growing health problem in India and worldwide, due to changes in lifestyle."( Ben-Shlomo, Y; Bowen, L; Ebrahim, S; Ekelund, U; Kinra, S; Krishna, KV; Kulkarni, B; Kuper, H; Sullivan, R; Taylor, AE; Wells, JC, 2015)
"Obesity is a complex metabolic disease that is a serious detriment to both children and adult health, which induces a variety of diseases, such as cardiovascular disease, type II diabetes, hypertension and cancer."( Ding, Z; Fan, W; Fan, Y; Gu, G; Liu, Y; Xu, Y; Xue, K, 2015)
"Maternal obesity is associated with an increased risk of pregnancy complications, including gestational diabetes."( Bell, R; Hayes, L; Kinnunen, TI; Mcparlin, C; Poston, L; Robson, SC, 2015)
"Obesity is a growing global concern with strong associations with cardiovascular disease, cancer and type-2 diabetes."( Chrousos, GP; Dnyansagar, R; Eriksson, A; Frediksson, R; Hansson, I; Herisson, FM; Krishnan, A; Manios, Y; Moschonis, G; Olszewski, PK; Philippot, G; Schiöth, HB; Voisin, S; Williams, MJ; Yamskova, O, 2015)
"The prevalence of obesity is increasing during the past decade along with obesity-related glomerulopathy (ORG), glomeruli injury due to the obesity."( Jaruvongvanich, V; Kanjanabuch, T; Leelahavanichkul, A; Nouanthong, P; Pongpirul, K; Pongpirul, WA; Suwanpen, C, 2016)
"Obesity is characterised by low-grade inflammation, which increases the metabolic syndrome (MetS) and cardiovascular risks."( Campos, RM; Carnier, J; Carvalho-Ferreira, JP; Corgosinho, FC; Dâmaso, AR; de Mello, MT; de Piano, A; Masquio, DC; Nascimento, CM; Netto, BD; Oyama, LM; Sanches, PL; Tufik, S, 2015)
"Obesity is a risk factor associated with several lifestyle-related diseases, for example, diabetes, high blood pressure, hyperlipidemia and cancer."( Hosaka, M; Imai, M; Kumaoka, T; Li, C; Saito, S; Sato, Y; Sudoh, M; Takahashi, N; Tamada, Y; Tsubuki, M; Yokoe, H, 2015)
"Obesity is a risk factor for not only of severe acute pancreatitis, but also PC at that independently of diabetes."( Efimova, OV; Grigor'eva, IN; Suvorova, TS; Tov, NL, 2014)
"Diabetes and obesity are worldwide health problems."( Andrade-Oliveira, V; Câmara, NO; Moraes-Vieira, PM, 2015)
"Obesity is characterized by low-grade inflammation and oxidative stress."( Bourgeois, H; Demeyere, K; Hesta, M; Meyer, E; Vandermeulen, E; Vlaeminck, B; Xu, J, 2015)
"Diabetes and obesity are associated with nonalcoholic fatty liver disease (NAFLD) and an increased incidence of hepatocellular carcinoma (HCC)."( Noureddin, M; Rinella, ME, 2015)
"Maternal obesity is associated with a high risk for gestational diabetes mellitus (GDM), which is a common complication of pregnancy."( Aliani, M; Campbell, KE; Cole, LK; Dolinsky, VW; Doucette, CA; Fonseca, MA; Hatch, GM; Klein, J; Moyce, BL; Pereira, TJ, 2015)
"Obesity is a common disease worldwide that often results in serious conditions including hypertension, diabetes, and hyperlipidemia."( Hong, SP; Im, JY; Jin, JS; Ki, HH; Kim, DK; Kim, YH; Kwon, SU; Lee, YM; Xin, M, 2015)
"Obesity is associated with non-alcoholic fatty liver disease (NAFLD), and the patatin-like phospholipase 3 (PNPLA3) rs738409 (Ile148Met, C>G) gene polymorphism is one of the most important genetic determinants of NAFLD."( Aigner, E; Baumgartner, BG; Haybaeck, J; Lackner, C; Mangge, H; Prüller, F; Reininghaus, EZ; Schnedl, WJ; Stauber, R; Weghuber, D; Zelzer, S, 2015)
"As obesity is one of the major risk factors of chronic and end-stage renal disease, we studied the role of Smad3 signaling in the pathogenesis of obesity-related renal disease."( Bertram, JF; Caruana, G; Dai, L; Fu, P; Howard, V; Jiang, X; Li, J; Nikolic-Paterson, DJ; Puelles, VG; Qu, X; Ren, Y; Sleeman, MW; Sun, YB, 2015)
"Obesity is associated with increased mineralocorticoid receptor (MR) activity in peripheral and possibly central tissues, decreased hippocampal size in humans, and impaired hippocampal learning in rodents."( Adler, GK; Garg, R; Rotenstein, LS; Sheridan, M, 2015)
"Obesity is considered a public health problem worldwide."( Aguila, MB; Bringhenti, I; Mandarim-de-Lacerda, CA; Penna-de-Carvalho, A; Rachid, TL; Souza-Mello, V, 2015)
"Obesity is a major risk factor for diabetes and peripheral arterial disease, which frequently leads to lower limb demand ischemia."( Albadawi, H; Austen, WG; Milner, JD; Oklu, R; Uong, TP; Watkins, MT; Yoo, HJ, 2015)
"Obesity is a risk factor for infertility and adverse reproductive outcomes."( Kallen, CB; Kawwass, JF; Summer, R, 2015)
"Obesity is common following hypothalamic damage due to tumours."( Cross, AA; Cuthbertson, DJ; Daousi, C; Halford, JC; Harrold, JA; Javadpour, M; Kemp, GJ; Kumar, SV; MacFarlane, IA; Powell, JL; Stancak, AA; Steele, CA; Wilding, JP, 2015)
"Obesity is characterized by hyperleptinemia and decreased response to exogenous leptin."( D'Alessio, DA; Gertler, A; Mahbod, P; Norman, LA; Ottaway, N; Perez-Tilve, D; Rivero, B, 2015)
"Obesity is a worldwide pathological condition that strongly impairs human health, and, to date, no effective therapy against excessive fat accumulation has been found yet."( Ciofani, G; Giorgi, M; Mattoli, V; Moscato, S; Nitti, S; Rocca, A; Ronca, F, 2015)
"Obesity is now a significant problem worldwide."( Ciofani, G; Giorgi, M; Mattoli, V; Moscato, S; Nitti, S; Rocca, A; Ronca, F, 2015)
"Obesity is a social problem worldwide that leads to several diseases, including metabolic syndrome, hypertension and cardiovascular diseases."( Almási, A; Barkai, L; Fehér, V; Kiss-Tóth, E; Ságodi, L, 2015)
"Obesity is characterized by a positive energy balance and expansion of white adipose tissue (WAT)."( Bloch, W; Etzrodt, J; Fischer, AWC; Friebe, A; Heeren, J; Hoffmann, LS; Pfeifer, A; Sanyal, A; Scheja, L; Stasch, JP; Willkomm, L, 2015)
"Obesity is increasing, yet despite the necessity of maintaining muscle mass and function with age, the effect of obesity on muscle protein turnover in older adults remains unknown."( Greenhaff, PL; Mallinson, JE; Marimuthu, K; Murton, AJ; Rennie, MJ; Selby, AL; Smith, K, 2015)
"Obesity is associated with high levels of circulating leptin."( Bozza, PT; Cruz, AL; Fazolini, NP; Maya-Monteiro, CM; Viola, JP; Werneck, MB, 2015)
"Obesity is a risk factor for the development of hormone receptor (HR)-positive breast cancer in postmenopausal women."( Bhardwaj, P; Dannenberg, AJ; Du, B; Falcone, DJ; Giri, D; Harbus, MD; Hudis, CA; Subbaramaiah, K; Sue, E; Zhou, XK, 2015)
"Obesity is reported to be a predictor of iron deficiency."( Martínez-Báez, AZ; Martínez-Garza, NE; Ramírez-López, E; Solís-Pérez, E; Tijerina-Sáenz, A, 2015)
"Obesity is a leading public health problem worldwide."( Cottone, P; Sabino, V; Steardo, L; Valenza, M, 2015)
"Obesity is a strong predictive factor in the development of chronic disease and has now superseded undernutrition as a major public health issue."( Brimelow, RE; Cox, AJ; Cripps, AW; West, NP; Williams, LT, 2017)
"Obesity is a chronic condition in which destructive mechanisms increase the reactive oxygen species and attenuation of antioxidant status."( Mahboob, S; Pourahmadi, Z; Reykandeh, MT; Saedisomeolia, A, 2015)
"Overweight and obesity are associated with significant morbidity and mortality."( Howland, RH, 2015)
"Obesity is a disorder that develops from the interaction between genotype and environment involving social, behavioral, cultural, and physiological factors."( Antza, C; Engeli, S; Grassi, G; Jordan, J; Kotsis, V; Luft, F; Mancia, G; Nilsson, P; Pall, D; Redon, J; Schlaich, M; Schmieder, R; Stabouli, S, 2015)
"Obesity is frequently associated with insulin resistance."( Alonso-Magdalena, P; García-Arévalo, M; Gonzalez, A; Lluesma, M; Marroquí, L; Merino, B; Nadal, A; Ñeco, P; Quesada, I, 2015)
"Obesity is associated with asthma risk and severity, but the underlying biological mechanisms are poorly understood."( Goh, DY; Ho, R; Kuan, WS; Larbi, A; Lim, TK; Lu, Y; Mahadevan, M; Ng, TP; Sim, TB; Van Bever, HP, 2015)
"Obesity is a risk factor for breast cancer progression."( Goloubeva, O; McLenithan, J; Sabnis, G; Schech, A; Yu, S, 2015)
"Obesity is often associated with leptin resistance, which leads to a physiological system with high leptin concentration but unable to respond to leptin signals and to regulate food intake."( Crauste, F; Jacquier, M; Soula, HA, 2015)
"Obesity is a prevalent disease with more than two thirds of Americans being considered overweight and one third being obese."( Bragg, R; Crannage, E, 2016)
"Obesity is a chronic disease with serious health consequences, but weight loss is difficult to maintain through lifestyle intervention alone."( Astrup, A; Fujioka, K; Greenway, F; Halpern, A; Jensen, CB; Krempf, M; Lau, DC; le Roux, CW; Pi-Sunyer, X; Violante Ortiz, R; Wilding, JP, 2015)
"Obesity is a common cause of hyperlipidemia, which is a major coronary risk factor."( Chung, YH; Hong, SM; Jeong, JH; Kim, HC; Kim, ST; Lee, HS; Lee, YJ; Nam, Y; Park, ES; Yang, YK, 2015)
"Since obesity is linked to altered experience of food reward and to perturbations of nutrient sensing, we investigated flavor-nutrient learning in rats made obese using a high fat/high carbohydrate (HFHC) choice model of diet-induced obesity (ad libitum lard and maltodextrin solution plus standard rodent chow)."( Myers, KP; Wald, HS, 2015)
"Obesity is a risk factor for some types of cancers."( Akhavan, MM; Alasvand, M; Javanmard, SH; Khazaei, M; Rashidi, B, 2015)
"Obesity is linked to type 2 diabetes (T2D) and cardiovascular diseases; however, the underlying molecular mechanisms remain unclear."( Blankenberg, S; Chen, YD; Chuang, CC; de la Fuente, A; Ding, J; Goodarzi, MO; Herrington, D; Hoeschele, I; Howard, T; Huang, Z; Jacobs, DR; Kritchevsky, SB; Liu, Y; Lohman, K; McCall, CE; Müller, C; Murphy, S; Nicklas, BJ; Parks, JS; Post, W; Reynolds, LM; Rotter, JI; Settlage, RE; Siscovick, DS; Soranzo, N; Tracy, RP; Wild, PS; Xu, N; Zeller, T, 2015)
"Obesity is a multifactorial disease associated with hypertension."( Belin De Chantemèle, EJ; Huby, AC, 2015)
"Obesity is a chronic inflammatory condition and is strongly linked to raised levels of pro-inflammatory factors and may lead to fatty infiltration of multiple internal organs including the gallbladder and liver, causing organ dysfunction."( Baik, GH; Kim, DL; Kim, JB; Kim, YJ; Kim, YS; Suk, KT; Yoon, JH, 2014)
"Obesity is well associated as being an interfering factor in metabolic diseases such as hypertension and diabetes by increasing the secretion of proinflammatory markers from adipose tissue."( Abed, Y; Ellulu, MS; Khaza'ai, H; Patimah, I; Rahmat, A, 2015)
"Obesity is well associated as being an interfering factor in metabolic diseases such as hypertension and diabetes by increasing the secretion of proinflammatory markers from adipose tissue."( Abed, Y; Ellulu, MS; Khaza'ai, H; Patimah, I; Rahmat, A, 2015)
"Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X."( Buzadzic, B; Daiber, A; Jankovic, A; Korac, A; Korac, B; Otasevic, V; Stancic, A, 2015)
"Obesity is more strongly associated with increased prostate cancer risk among African American than non-Hispanic white men and reducing obesity among African American men could reduce the racial disparity in cancer incidence."( Arnold, KB; Barrington, WE; Etzioni, R; Kristal, AR; Lucia, MS; Neuhouser, ML; Schenk, JM; Thompson, IM, 2015)
"Obesity is associated with multiple comorbidities and increased mortality, making it an important target for treatment."( Fujioka, K; Krogsgaard, S; Kushner, RF; Sparre, T; Sun, LY, 2015)
"Obesity is the main risk factor for type 2 diabetes mellitus."( da Cunha, MA; da Silva, LA; Grassiolli, S; Hocayen, Pde A; Kagimura, FY; Leite, NC; Malfatti, CR; Michel, RG; Pereira, RA; Pochapski, MT; Snack, AL, 2016)
"Since maternal obesity is on the rise, we wanted to identify the effects of prenatal stress in the offspring of diet-induced obese (DIO) rats and compare them with the offspring of dietary-resistant (DR) rats."( Abdallah, SL; Balasubramanian, P; MohanKumar, PS; MohanKumar, SM; Najjar, SM; Varde, PA, 2015)
"Obesity is a risk factor for both vitamin D deficiency and cardiovascular disease."( Al-Daghri, NM; Chrousos, GP; Garbis, SD; Manousopoulou, A, 2015)
"Obesity is increasing in prevalence and is strongly associated with metabolic and cardiovascular disorders."( Basu, R; Das, SK; Grant, MB; Lopaschuk, GD; McLean, BA; Mori, J; Oudit, GY; Parajuli, N; Patel, VB; Penninger, JM; Ramprasath, T, 2016)
"Obesity is a multi-factorial disorder influenced by genetic and environmental factors."( Mittal, B; Prakash, J; Srivastava, A; Srivastava, N; Srivastava, P, 2016)
"Hypertension and obesity are known to be linked, with recent studies in mice proposing that leptin may be mediating this effect."( Brown, RJ; Gorden, P; Meehan, CA, 2015)
"Obesity is associated with adverse atherosclerotic cardiovascular events."( Duggal, B; Hammadah, M; Kapadia, SR; Kataoka, Y; Nicholls, SJ; Nissen, SE; Puri, R; Tuzcu, EM; Uno, K, 2015)
"Obesity is a worldwide individual and public health issue, and contributes to the development of numerous chronic diseases."( An, BS; An, SM; Hwang, DY; Jung, YJ; Kang, EJ; Kim, BC; Kim, JM; Kim, SC; Kim, SJ; Kwon, HS; Lee, JE; Lee, JH; Yang, SY, 2015)
"Obesity is associated with interleukin-6 and interferon gamma expression and with overt tyrosine nitration in both feline and canine ATMs."( Ampem, G; Azegrouz, H; Bacsadi, Á; Balogh, L; Röszer, T; Schmidt, S; Thuróczy, J, 2016)
"Obesity is a serious medical condition that affects children and adolescents."( Alhadramy, O; Biomy, NM; Fawzy, MS; Hussein, MH; Ismail, HM; Ismail, NM; Toraih, EA, 2015)
"Considering that obesity is strongly related to a chronic inflammatory state in white adipose tissues, it is possible that Gn-GC-C macrophages contribute to the regulation of inflammation."( Akieda-Asai, S; Bae, CR; Date, Y; Fujii, Y; Hasegawa, K; Yasuda, M, 2015)
"Obesity is a cluster of medical conditions affecting several pathophysiological processes, including platelet (PLT) function."( Gąsior, Z; Haberka, M; Kyrcz-Krzemień, S; Lasota, B; Mizia-Stec, K, 2015)
"CONCLUSIONS Obesity is associated with a lower response to CLO LD but PLT function after 30 days of CLO MD is similar in patients with obesity and normal-weight."( Gąsior, Z; Haberka, M; Kyrcz-Krzemień, S; Lasota, B; Mizia-Stec, K, 2015)
"Obesity is a progressive metabolic disorder in the current world population, and is characterized by the excess deposition of fat in the adipose tissue."( Bondili, JS; Chalasani, LM; Raj, KK; Talluri, VR; Veeramachaneni, GK, 2015)
"nucifera, on obesity are not fully understood."( Choi, JS; Chung, HY; Jeong, HO; Kim, HR; Kwon, M; Lee, B, 2015)
"Obesity is associated with substantially increased CRC risk in patients with LS, but this risk is abrogated in those taking aspirin."( Bertario, L; Bisgaard, ML; Bishop, DT; Burn, J; Dunlop, MG; Eccles, D; Evans, DG; Ho, JW; Hodgson, SV; Lindblom, A; Lubinski, J; Macrae, F; Maher, ER; Mathers, JC; Mecklin, JP; Moeslein, G; Morrison, PJ; Movahedi, M; Murday, V; Olschwang, S; Ramesar, RS; Scott, RJ; Side, L; Thomas, HJ; Vasen, HF, 2015)
"Obesity is a major risk factor for the onset of type 2 diabetes; however, little is known about the gene(s) involved."( Kotoh, J; Matsumoto, K; Sasaki, D; Watadani, R, 2015)
"Obesity is a risk factor for cardiovascular disease."( Binkley, CM; Charnigo, RJ; Epstein, FH; Fornwalt, BK; Haggerty, CM; Jing, L; Kramer, SP; Mattingly, AC; Powell, DK; Suever, JD, 2015)
"Obesity is a risk factor for colorectal cancer."( Fujii, G; Fujimoto, K; Ishigamori, R; Ishino, K; Komiya, M; Miyamoto, S; Mutoh, M; Onuma, W; Takahashi, M; Totsuka, Y, 2015)
"Obesity is a multifactorial disorder which is closely associated with hyperlipidemia."( Geetha, A; Monika, P, 2015)
"Obesity is associated with increased expression of 5-lipoxygenase (5-LO) pathway and increased Leukotrienes (LTs) production has been observed in obese asthma patients."( Srivastava, SK; Yadav, UC, 2015)
"Childhood obesity is particularly problematic, because the co-morbid disease states which accompany obesity may require frequent pharmacotherapy and/ or surgical intervention."( van den Anker, JN; Vaughns, JD; Ziesenitz, VC, 2015)
"Obesity is associated with adipose tissue dysfunction leading to the onset of several pathologies including type 2 diabetes, dyslipidemia, nonalcoholic fatty liver, or hypertension, among others."( Becerril, S; Ezquerro, S; Frühbeck, G; Méndez-Giménez, L; Rodríguez, A, 2015)
"Obesity is considered a state of chronic low-grade inflammation elicited by an immunological response."( Hryciw, DH; Hutchinson, DS; McAinch, AJ; Rajaraman, G; Simcocks, A, 2016)
"Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established."( Bluemke, DA; Criqui, MH; Harhay, MO; Kawut, SM; Kizer, JR; Lima, JA; Tracy, R, 2015)
"Morbid obesity is associated with alterations in cardiac remodeling, mainly left ventricular hypertrophy and diastolic dysfunction."( Antequera, A; Bartolomé, MV; Cachofeiro, V; Fernández-Celis, A; Islas, F; Jurado-López, R; López-Ándres, N; Luaces, M; Martínez-Martínez, E; Prieto, S; Rossignol, P; Rousseau, E, 2015)
"Obesity is a state of chronic, low-grade inflammation, and increased inflammation in the adipose and kidney tissues has been shown to promote the progression of renal damage in obesity."( Deng, L; Fang, Q; Liang, G; Pan, Y; Tong, C; Wang, J; Wang, L; Weng, Q; Yin, H; Zhang, Y, 2015)
"Because obesity is a common health problem in industrialized societies, cancer care providers are increasingly likely to treat obese patients in their practice."( Ashrani, A; Bockenstedt, PL; Chesney, C; Eby, C; Engh, AM; Fanikos, J; Fenninger, RB; Fogerty, AE; Gao, S; Goldhaber, SZ; Hendrie, P; Holmstrom, B; Kuderer, N; Lee, A; Lee, JT; Lovrincevic, M; McMillian, N; Millenson, MM; Neff, AT; Ortel, TL; Paschal, R; Shattil, S; Siddiqi, T; Smock, KJ; Soff, G; Streiff, MB; Wang, TF; Yee, GC; Zakarija, A, 2015)
"Obesity is a chronic disease that has been associated with chronic stress and hypercaloric diet (HD) consumption."( Caumo, W; de Macedo, IC; de Souza, IC; Filho, PR; Oliveira, Cd; Oliveira, CM; Quevedo, AS; Silva, FR; Torres, IL; Vercelino, R, 2015)
"Obesity is an important risk factor for the development of chronic kidney disease."( Bar Sheshet Itach, S; Chagnac, A; Erman, A; Gafter, U; Herman-Edelstein, M; Ori, Y; Rozen-Zvi, B; Zingerman, B, 2015)
"Obesity is associated with an increasing prevalence of cardiovascular diseases and metabolic syndrome."( Cao, K; Dong, Z; Feng, Z; Gao, F; Liu, J; Pu, W; Sun, L; Xu, J; Zang, W; Zhang, Y, 2015)
"Obesity is associated with a range of health outcomes that are of clinical and public health significance, including cancer."( Allott, EH; Hursting, SD, 2015)
"Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers."( Alfraidi, A; Alshaker, H; Muhammad, A; Pchejetski, D; Sacco, K; Winkler, M, 2015)
"Resistance to obesity is observed in rodents and humans treated with rapamycin (Rap) or nebivolol (Neb)."( Alfadda, AA; Gul, R; Luck, C; Lum-Naihe, K; Mahmood, A; Pulakat, L; Speth, RC, 2015)
"Obesity is involved in several cardiovascular diseases including coronary artery disease and endothelial dysfunction."( Escalante, B; Gamez-Mendez, AM; Ríos, A; Vargas-Robles, H, 2015)
"Obesity is increasing rapidly worldwide and is accompanied by many complications, including impaired muscle regeneration."( Du, M; Foretz, M; Fu, X; Viollet, B; Zhang, S; Zhu, M, 2016)
"Obesity is one of the major health problems throughout the world."( Matsui, H; Mori, H; Murakami, Y; Ojima-Kato, T; Saburi, W; Suzuki, T; Tanabe, S, 2015)
"Obesity is associated with several pain disorders including headache."( Broadhurst, KA; Kothari, SD; Lara, O; Luu, ASK; Mohapatra, DP; Recober, A; Rossi, HL, 2016)
"Obesity is one of the most important link factors to coronary artery disease development mainly due to the pro-inflammatory and pro-thrombotic states favoring atherosclerosis progression."( Bagnato, VS; da Silveira Campos, RM; Dâmaso, AR; de Aquino Junior, AE; Duarte, FO; Garcia de Oliveira Duarte, AC; Masquio, DC; Parizotto, NA; Sene-Fiorese, M; Tock, L, 2015)
"Obesity is a well-established risk factor for poor neurological outcomes, and bariatric surgery has been shown to improve many aspects of cognitive function."( Gunstad, J; Heinberg, L; Manderino, L; Spitznagel, MB, 2015)
"Obesity is defined as an individual who has Body Mass Index (BMI) ≥ 27."( Baharuddin, NA; Khan, S; Safii, SH; Saub, R; Vaithilingam, RD; Vethakkan, SR, 2015)
"Obesity is a significant problem in the United States, with roughly one third of adults having a body mass index (BMI) over thirty."( Chadderdon, AM; Ferrario, CR; Jutkiewicz, EM; Nobile, CW; Vollbrecht, PJ, 2015)
"Obesity is associated with a pro-inflammatory state and relative hypogonadotropic hypogonadism."( Al-Safi, ZA; Bradford, AP; Carlson, NE; Chosich, J; Gee, NA; Kohrt, W; Lesh, J; Liu, H; Phang, T; Polotsky, AJ; Robledo, C; Santoro, N, 2015)
"Maternal obesity is associated with increased systemic inflammation and an increased risk of preterm premature rupture of membranes."( DeWitt, PE; Faucett, AM; Gibbs, RS; Metz, TD, 2016)
"Obesity is caused by increased food intake and/or decreased energy expenditure."( Gantulga, D; Nakata, M; Okada, T; Okano, H; Ozawa, K; Yada, T; Yamamoto, S, 2016)
"Obesity is an increasingly important health problem worldwide as well as in developing countries like India."( Mittal, B; Prakash, J; Srivastava, A; Srivastava, N; Srivastava, P, 2016)
"Obesity is associated with increased fibrinogen production and fibrin formation, which produces fibrin degradation products (FDP-E and FDP-D)."( Kang, M; Paton, CM; Vaughan, RA, 2015)
"Obesity is a worldwide epidemic with more than 600 million affected individuals."( Bogorodzki, P; Gaździńska, A; Gazdzinski, SP; Janeczko, K; Karwowska, K; Kossowski, B; Majka, P; Orzeł, J; Osoba, JJ; Setkowicz, Z; Wyleżoł, M, 2015)
"Obesity is associated with abnormal lipid metabolism and impaired bone homeostasis."( Al-Sahli, A; Celenti, R; Cremers, S; Gold, T; Jiang, H; Kiefhaber, K; Muluke, M; Schulze-Späte, U; Van Dyke, T, 2016)
"As the incidence of obesity is increasing worldwide, there is an urgent need for adequate preclinical models and preclinical and clinical studies designed to investigate how to inhibit the tumor-promoting activity of the adipose tissue."( Bertolini, F; Orecchioni, S; Reggiani, F; Talarico, G, 2015)
"Obesity is associated with elevated plasma cysteine, whereas diabetes is associated with reduced cysteine levels."( Carter, RN; Morton, NM, 2016)
"Obesity is a major health priority necessitating safe and effective strategies to address the obesity epidemic."( Aronne, LJ; Kumar, RB; Shukla, AP, 2015)
"Asthma and obesity are public health problems with increasing prevalence worldwide."( Carvalho, CR; Carvalho-Pinto, R; Cukier, A; da Silva, A; Fernandes, FL; Ferreira, PG; Freitas, PD; Mancini, MC; Martins, MA; Salge, JM; Stelmach, R; Trecco, S, 2015)
"Obesity is associated with a lower probability of long-term success."( Bi, Y; Chen, M; Jin, Y; Li, Y; Pan, L; Shan, Y, 2016)
"Obesity is a risk factor for the development of human colorectal cancer (CC)."( Amor, S; Barrios, V; Fernandez, N; Ferrero, E; García-Villalón, AL; García-Villar, O; Granado, M; Iglesias-de la Cruz, MC; Monge, L, 2016)
"Obesity is one of the major risk factors for nonalcoholic fatty liver disease (NAFLD), and NAFLD is highly associated with an increased risk of cardiovascular disease (CVD)."( Chen, RJ; Chen, YH; Day, CH; Hsieh, DJ; Huang, CY; Kuo, WW; Padma, VV; Ting, WJ; Yeh, YL, 2015)
"Overweight and obesity are major risk factors for hypertension."( Seven, E, 2015)
"Obesity is a medical condition frequently associated with psychopathological symptoms and neurocognitive and/or personality traits related to impulsivity."( Amodio, P; Caregaro, L; di Pellegrino, G; Montagnese, S; Nardi, M; Schiff, S; Sellitto, M; Testa, G, 2016)
"Maternal obesity is associated with prolonged and dysfunctional labour and emergency caesarean section, but the mechanisms are unknown."( Ballan, J; Clifford, B; Elmes, M; Khan, R; McMullen, S; Muir, R; Quenby, S; Shmygol, A, 2016)
"Obesity is related to hormonal disorders that affect the reproductive system."( Becker, GF; Moulin, CC; Passos, EP, 2015)
"Obesity is associated with alterations in thyroid hormone (TH) levels in obese, pregnant individuals."( Aagaard, KM; Antony, KM; DelBeccaro, M; Hu, M; Kahr, MK; Suter, MA, 2016)
"Maternal obesity is not only associated with maternal alterations in TH, but with accompanying neonatal changes."( Aagaard, KM; Antony, KM; DelBeccaro, M; Hu, M; Kahr, MK; Suter, MA, 2016)
"Obesity is associated with multiple diseases."( Ernst, B; Gralka, E; Luchinat, C; Schultes, B; Tenori, L; Thurnheer, M, 2015)
"More importantly, obesity is thought to contribute to TD."( Traish, AM; Zitzmann, M, 2015)
"Obesity is a multifactorial health problem resulting from genetic, environmental, and behavioral factors."( Choi, JY; Choi, MS; Hwang, GS; Jung, S; Jung, Y; Nam, M; Ryu, DH, 2015)
"Obesity is usually associated with low-grade inflammation, which impairs insulin action."( Balbo, SL; Bonfleur, ML; Caetano, LC; Carneiro, EM; do Nascimento da Silva, J; Lubaczeuski, C; Nardelli, TR; Ribeiro, RA, 2017)
"Obesity is associated with disrupted reproductive cycles in mares, but the impact of obesity on follicles and oocytes has received minimal attention."( Carnevale, EM; Heuberger, AL; Schauer, KL; Sessions-Bresnahan, DR, 2016)
"Overweight and obesity are the accumulation of high body adiposity, which can have detrimental health effects and contribute to the development of numerous preventable non-communicable diseases."( Mondal, N; Rengma, MS; Sen, J, 2015)
"Obesity is associated with a downregulation of the Gr-Gilz axis in KC, which promotes liver inflammation."( Bigorgne, A; Bouchet-Delbos, L; Boujedidi, H; Capel, F; Cassard, AM; Dagher, I; Douard, R; Durand-Gasselin, I; Emilie, D; Ferrere, G; Gary-Gouy, H; Gaudin, F; Godot, V; Hemon, P; Lombès, M; Naveau, S; Perlemuter, G; Prévot, S; Puchois, V; Robert, O; Rousset, S; Tran, T; Tuckermann, JP; Vettorazzi, S; Voican, CS, 2016)
"Obesity is a worldwide epidemic associated with multiple comorbidities that increase the risk of hospitalization."( Hall, RG; Payne, KD, 2016)
"Obesity is characterized by a dysregulated immune system, which may causally associate with insulin resistance and type 2 diabetes."( Bortell, R; Dagdeviren, S; Friedline, RH; Greiner, DL; Hu, X; Inashima, K; Jung, DY; Kearns, C; Kim, JK; Ko, HJ; Lee, KW; Lee, Y; Patel, PR; Shafiq, U; Shultz, LD; Tsitsilianos, N, 2016)
"Obesity is a metabolic, multifactorial disease that is underpinned by factors such as genetics, epigenetics, as well as high-energy food intake and sedentarism."( Nunes, EA; Rafacho, A, 2017)
"Obesity is rising to unprecedented numbers, affecting a growing number of children, adolescents and young adult men."( Alves, MG; Goldberg, E; Jesus, TT; Oliveira, PF; Silva, BM; Sousa, M, 2016)
"Obesity is closely associated with metabolic disorders such as hyperglycemia and dyslipidemia."( Han, SI; Hwang, SY; Lee, E; Lee, YM; Park, E; Won, YJ; Yeum, KJ, 2016)
"In women, obesity is associated with decrements in reproductive health that are improved with weight loss."( Clegg, DJ; Frank, AP; Zechner, JF, 2016)
"Obesity is associated with an increased risk of many chronic diseases."( Lu, K; Rashid, AM; Yip, YM; Zhang, D, 2016)
"Obesity is one of the major challenges for public health in 21st century, with 1."( Dubey, V; Ghosh, AR; Mishra, AK, 2016)
"Maternal obesity is known to predispose the offspring to impaired glucose metabolism and obesity associated with low-grade inflammation and hypothalamic dysfunction."( Alejandre Alcazar, MA; Bae-Gartz, I; Dinger, K; Dötsch, J; Ferrari, N; Graf, C; Hucklenbruch-Rother, E; Janoschek, R; Kloppe, CS; Lippach, G; Muether, PS; Oberthür, A; Roels, F; Vohlen, C, 2016)
"Pandemic obesity is the most pressing health issue of this century."( Bloom, SR; Choudhury, SM; Tan, TM, 2016)
"Obesity is associated with a worse breast cancer prognosis, while greater breast tumor estrogen receptor beta (ERβ) expression is correlated with improved therapy response and survival."( Bowers, LW; Brenner, AJ; deGraffenried, LA; Hursting, SD; Rossi, EL; Tekmal, RR; Wiese, M, 2015)
"Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications."( Brouwers, O; Cleutjens, JP; Gaens, KH; Janssen, BJ; Maessen, DE; Miyata, T; Schalkwijk, CG; Stehouwer, CD; Wouters, K, 2016)
"Obesity is considered detrimental to women's reproductive health."( Hammes, SR; Hayes, E; Ma, X; Prizant, H; Sen, A; Srivastava, RK, 2016)
"Obesity is a risk factor for heart failure (HF) but is associated with lower N-terminal pro-brain natriuretic peptide (NT-proBNP) levels."( Agarwal, SK; Ballantyne, CM; Blumenthal, RS; Coresh, J; Deswal, A; Lazo, M; Matsushita, K; Nambi, V; Ndumele, CE; Sang, Y; Selvin, E, 2016)
"Diet-induced obesity is frequently used to demonstrate cardiac dysfunction."( Campos, DH; Castardeli, E; Cicogna, AC; Cunha, MR; Estevam, WM; Ferron, AJ; Jacobsen, BB; Leopoldo, AS; Lima-Leopoldo, AP; Sá, FG, 2015)
"Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear."( Aing, A; Blomain, E; Blumberg, RS; Colon-Gonzalez, F; Hyslop, TM; Kim, GW; Lin, JE; Rock, J; Snook, AE; Stoecker, B; Tomczak, M; Waldman, SA; Zhan, T, 2016)
"Overweight/obesity is associated with chronic inflammation and impairs both innate and adaptive immune responses."( Adkins, YC; Bonnel, EL; Breksa, AP; Freytag, TL; Kelley, DS; Mackey, BE; Manners, GD; Storms, DH; Woodhouse, LR; Zunino, SJ, 2016)
"Obesity is caused by excessive accumulation of body fat and is closely related to complex metabolic diseases."( Chen, YY; Ho, CT; Kalyanam, N; Lai, CS; Lee, PS; Liou, WS; Pan, MH; Yu, RC, 2016)
"Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term."( Bazi, Z; Hekmatdoost, A; Jalili, M, 2016)
"Obesity is a multifactorial disease that comes from an imbalance between food intake and energy expenditure."( Dajori, AL; Daumann, F; de Andrade, VM; Gomes, LM; Leffa, DD; Longaretti, LM; Rezin, GT; Silva, MC; Streck, EL, 2017)
"The prevalence of obesity is increasing worldwide, with high fat diet (HFD) as one of the main contributing factors."( Abdul Hamid, A; Gooda Sahib Jambocus, N; Ismail, A; Khatib, A; Mahomoodally, MF; Saari, N, 2016)
"Obesity is an established risk factor for postmenopausal breast cancer (BCa), insulin resistance, and vitamin D deficiency, and all contribute to increased synthesis of mammary estrogens, the drivers of estrogen receptor-positive (ER+) BCa growth."( Aggarwal, A; Albertelli, MA; Feldman, BJ; Feldman, D; Horst, RL; Krishnan, AV; Swami, S; Williams, J, 2016)
"Although obesity is a risk factor for NAFLD, overlap between these two entities is incompletely understood."( Lavine, JE; Woo Baidal, JA, 2016)
"Obesity is a common risk factor for non-alcoholic fatty liver disease (NAFLD)."( Aleksic, M; Favero, G; Golic, I; Korac, A; Lavazza, A; Rezzani, R; Rodella, LF; Stacchiotti, A, 2016)
"Overweight and obesity are becoming more and more relevant for armed forces in westernized countries, especially with respect to the impact on recruitment and soldiers' performance."( Sammito, S, 2015)
"Obesity is associated with an increased risk of adverse pregnancy outcomes."( Akolekar, R; Balani, J; Hyer, S; Kotecha, R; Nicolaides, KH; Pastides, A; Shehata, H; Syngelaki, A, 2016)
"Obesity is one of the main risk factors of non-communicable diseases (NCDs) worldwide, especially in sub-Saharan Africa."( Bavuidibo, CD; Kabundji, DM; Lulebo, AM; Mafuta, EM; Mputu, LC; Mutombo, PB; Ndelo, JD, 2016)
"The prevalence of obesity is still rising in many countries, resulting in an increased risk of associated metabolic diseases."( Fuchs, H; Gailus-Durner, V; Hoeschen, C; Hrabě de Angelis, M; Kistler, M; Klingenspor, M; Muntean, A; Rink, N; Rozman, J; Szymczak, W; Wurst, W, 2016)
"Although obesity is associated with increased systemic levels of placental growth factor (PlGF), the role of PlGF in obesity-induced tumor progression is not known."( Ancukiewicz, M; Babykutty, S; Batista, A; Carmeliet, P; Chin, SM; Duda, DG; Fukumura, D; Hato, T; Hoffmman, U; Incio, J; Jain, RK; Jung, K; Khachatryan, A; Krop, IE; Ligibel, JA; McManus, DT; Puchner, SB; Rahbari, NN; Schlett, CL; Shibuya, M; Soares, R; Suboj, P; Tam, J; Vardam, TD, 2016)
"Obesity is associated with increased fever and sickness behavior in response to infection."( Astiz, M; Barrios, V; Diz-Chaves, Y; Garcia-Segura, LM; Pernía, O, 2017)
"Overweight and obesity are prevalent in high CV risk patients with T2DM."( Baeres, FM; Bain, S; Comlekci, A; Eriksson, M; Franek, E; Jacob, S; Leiter, LA; Marso, SP; Masmiquel, L; Petrie, J; Raz, I; van Gaal, L; Vidal, J, 2016)
"Prevalence of obesity is four times higher in patients with prolactinomas than in patients with nonfunctional adenomas."( Butorac, D; Jović, A; Kruljac, I; Pećina, HI; Perić, B; Štefanović, M; Šundalić, S; Vrkljan, M, 2016)
"Obesity is an important risk factor for breast cancer (BC) in postmenopausal women; interlinked molecular mechanisms might be involved in the pathogenesis."( Argentiero, A; D'Avenia, M; De Pergola, G; Felici, C; Rizzo, FM; Silvestris, F; Simone, V, 2016)
"Obesity is a major public health problem worldwide."( Korytkowski, M; Rariy, CM; Rometo, D, 2016)
"Hypertension and obesity are two major threats for public health."( Akkaya, N; Cakmak, M; Çelik, HT; Demircelik, B; Erdamar, H; Gok, S; Kazanci, F; Yigitoglu, R, 2015)
"Obesity is a global epidemic affecting over 1."( Agrawal, S; Jagannadham, J; Jaiswal, HK; Rawal, K, 2016)
"Obesity is characterized by iron deficiency, carbohydrate and fat alterations as well as oxidative stress."( Bensenane, B; Berroukeche, F; Cherrak, S; Elhabiri, M; Imessaoudene, A; Merzouk, H; Merzouk, SA; Mokhtari, N, 2016)
"Obesity is a well-established risk factor to health for its relationship with insulin resistance, diabetes and metabolic syndrome."( Chen, J; Chu, W; Gao, Y; Han, H; Shi, X; Sun, W; Wei, W; Yu, S; Zhang, L, 2016)
"Obesity is a major risk factor for type 2 diabetes, which is caused mainly by insulin resistance."( Furusho, T; Kobayashi, K; Ota, T; Sato, M; Shichi, Y; Shirai, T; Suzuki, T; Tadokoro, T; Tanioka, Y; Yamamoto, Y, 2016)
"Obesity is largely due to the imbalance of energy intake and expenditure, therefore we have put more emphasis on the amount of macronutrients including carbohydrates, fats and proteins as dietary therapy for obesity and related-conditions."( Kuroda, M; Sakaue, H, 2016)
"Obesity is a growing epidemic in developed countries."( Aubrecht, TG; Fonken, LK; Gaudet, AD; Gushchina, LV; Maurya, SK; Nelson, RJ; Periasamy, M; Popovich, PG, 2016)
"Obesity is associated with chronic low-grade inflammation."( Donma, MM; Donma, O, 2016)
"Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown."( Bain, JR; Cohen, HJ; Huffman, KM; Kraus, VB; Kraus, WE; Morey, MC; Newgard, CB; Pieper, CF; Ravussin, E; Redman, LM; Stevens, RD; Thompson, DK, 2016)
"Diet-induced obesity is associated with strong circadian changes in food intake, but the contributing mechanisms have yet to be determined."( Kennaway, DJ; Kentish, SJ; Page, AJ; Vincent, AD; Wittert, GA, 2016)
"Maternal obesity is associated with an increased risk of chronic disease in offspring, including type 2 diabetes (T2D)."( Chen, H; Gill, AJ; Glastras, SJ; McGrath, RT; Pollock, CA; Saad, S; Zaky, AA, 2016)
"Obesity is strongly associated with prevalence of obstructive sleep apnea (OSA), and weight loss has been shown to reduce disease severity."( Aronne, L; Blackman, A; Claudius, B; Foster, GD; Jensen, CB; Mignot, E; Rosenberg, R; Wadden, T; Zammit, G, 2016)
"Obesity is pandemic in the Western Hemisphere, especially in the United States (US) and is associated with morbidity and mortality."( Bazan, IS; Fares, WH, 2016)
"Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated."( Collins, AJ; Gimi, B; Hazlett, HF; Kerley-Hamilton, JS; Kinlaw, WB; Lupien, LE; Moyer, BJ; Nemani, KV; Ringelberg, CS; Rojas, IY; Tomlinson, CR; Trask, HW; West, RJ, 2016)
"Obesity is one of the main predisposing factors for obstructive sleep apnea (OSA) hypopnea syndrome."( Borsini, E; Bosio, M; Dibur, E; Ernst, G; Nigro, C; Salvado, A, 2016)
"Obesity is a complex process involving genetic and environmental factors with an epidemiological burden that makes it a major public health issue."( Compare, D; Nardone, G; Rocco, A; Sanduzzi Zamparelli, M, 2016)
"Obesity is positively associated with colorectal cancer."( Abubakar, M; Aleksandrova, K; Barricarte, A; Boutron-Ruault, MC; Bueno-de-Mesquita, HB; Cross, AJ; Dorronsoro, M; Dossus, L; Ericson, U; Freisling, H; Gunter, MJ; Huerta, JM; Jakszyn, P; Jenab, M; Katzke, VA; Khaw, KT; Kong, SY; Krogh, V; Kühn, T; Lagiou, P; Masala, G; Molina-Montes, E; Muller, DC; Murphy, N; Nyström, H; Ohlsson, B; Overvad, K; Palmqvist, R; Panico, S; Peeters, PH; Petersen, KE; Quirós, JR; Racine, A; Riboli, E; Siersema, PD; Skeie, G; Tjønneland, A; Travis, RC; Trichopoulos, D; Trichopoulou, A; Tsilidis, K; Tumino, R; Vineis, P; Wareham, N; Weiderpass, E, 2016)
"Obesity is one of the direct cause of hypertension."( Trojanek, JB, 2015)
"Obesity is associated with compromised intestinal barrier function and shifts in gastrointestinal microbiota that may contribute to inflammation."( Cephas, KD; Holscher, HD; Kerr, KR; Liu, TW; Mangian, HF; Swanson, KS; Tappenden, KA, 2016)
"Obesity is the increased accumulation of triglycerides (TG), which are synthesized from glycerol and long-chain fatty acids (LCFA) throughout the body."( Berk, PD; Verna, EC, 2016)
"Obesity is positively related to the growing prevalence of coronary arterial disease (CAD)."( Chan, SH; Cheng, YH; Chu, PM; Hung, CH; Kao, CL; Tsai, KL, 2016)
"Obesity is a complex disorder and has been increasing globally at alarming rates including Pakistan."( Hasnain, S, 2016)
"Childhood obesity is a risk factor for asthma, but the molecular mechanisms linking both remain elusive."( Alejandre Alcázar, MA; Bae-Gartz, I; Dinger, K; Dötsch, J; Hucklenbruch-Rother, E; Janoschek, R; Jobst, E; Kasper, P; Plank, C; van Koningsbruggen-Rietschel, S; Vohlen, C, 2016)
"Childhood obesity is a public health problem worldwide."( Bhansali, A; Bharti, B; Dhawan, V; Thakur, JS; Tripathy, JP, 2016)
"Obesity is related to diabetes, higher oxidative stress and nonalcoholic fatty liver disease, and dietetic therapies, for instance calcium-rich diet, can improve these dysfunctions."( Ai, XX; Conceição, EP; Figueiredo, MS; Lisboa, PC; Moura, EG; Oliveira, E; Soares, PN, 2016)
"Obesity is a risk factor for several pain syndromes and is associated with increased pain sensitivity."( Hou, J; Li, D; Li, H; Song, C; Zhang, Y, 2016)
"Although obesity is characterized by catecholamine resistance in subcutaneous adipose tissue (SCAT), data on ANP lipolytic response and sensitivity in different adipose tissue (AT) depots of metabolically distinct humans are scarce."( Blaak, EE; Bouckaert, W; Dams, A; Eijnde, BO; Hansen, D; Hoebers, N; Jocken, JW; Knol, J; Moro, C; Verboven, K, 2016)
"Obesity is associated with hyperlipidemia, electrical remodeling of the heart, and increased risk of supraventricular arrhythmias in both male and female patients."( Aromolaran, AS; Boutjdir, M; Colecraft, HM, 2016)
"Obesity is a major health problem characterized by accumulated fat mass."( Gumbs, MC; la Fleur, SE; van den Heuvel, JK, 2016)
"Obesity is reported to be associated with immune dysfunction and a state of low-grade, chronic inflammation."( Feng, Z; Liu, J; Liu, Y; Pang, W; Sun, W; Wang, X; Zhang, Y; Zhang, Z; Zhao, F; Zhao, J, 2016)
"Obesity is characterized by an accumulation of excessive body fat and can be diagnosed by a variety of measures, such as BMI."( Chi, MH; Guo, L; Huang, X; Li, QM; Zhang, XM, 2016)
"Mice with obesity are more susceptible to sepsis and have higher mortality, in part, through activation of the STAT3 signaling pathway and through activator protein-1 activation."( Kaplan, JM; Lahni, P; Nowell, M; Shanmukhappa, SK; Shen, H; Zingarelli, B, 2016)
"Obesity is a known risk factor for breast cancer and has been linked to increased risk of recurrence and death in breast cancer patients."( Bregni, G; de Braud, F; Di Cosimo, S; Festinese, F; Galli, G; Ganzinelli, M; Gevorgyan, A; Lo Vullo, S; Mariani, L; Martinetti, A; Sottotetti, E, 2016)
"Obesity is associated with insulin resistance and reduced transport of insulin through the blood-brain barrier (BBB)."( Bedel, ND; Liu, M; May, AA; Shen, L; Woods, SC, 2016)
"Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome."( Bardova, K; Gardlo, A; Hansikova, J; Horakova, O; Kopecky, J; Kuda, O; Rombaldova, M; Rossmeisl, M, 2016)
"Obesity is well-established as a major cardiovascular (CV) risk factor."( Lane, DA; Lip, GY; Proietti, M, 2016)
"Obesity is characterized by the rapid expansion of visceral adipose tissue, resulting in a hypoxic environment in adipose tissue which leads to a profound change of gene expression in adipocytes."( Brandtner, EM; Drexel, H; Fraunberger, P; Kinz, E; Leiherer, A; Muendlein, A; Saely, CH; Stoemmer, K, 2016)
"Obesity is often associated with a state of oxidative stress and increased lipid deposition in the heart."( Fungwe, TV; Gharib, M; Hajri, T; Tao, H, 2016)
"Obesity is a disorder with increasing frequency in children and adolescents, directly linked with various diseases."( Bănescu, C; Duicu, C; Mărginean, CO; Tripon, F; Voidăzan, S, 2016)
"Obesity is associated with an increased risk of cancer."( Chi, E; Kuo, Y; Liu, A; Wang, H; Yang, CS; Yang, X; Zhang, L, 2016)
"Obesity is thought to be associated with upregulation of intra-renal angiotensin II (Ang II) signaling via the Ang II Type 1 receptor (AT₁R) and Ang II suppresses megalin expression in proximal tubule cells in vitro."( Aroor, A; Duta, C; Meuth, A; Nistala, R; Sowers, JR; Whaley-Connell, A; Zuberek, M, 2016)
"Obesity is also associated with chronic, low-grade inflammation and sustained, elevated levels of SAA1."( Choi, M; Jang, WY; Jeong, J; Kang, MC; Kim, MO; Kim, S; Kim, SH; Park, SJ; Ryoo, ZY; Sung, YH, 2016)
"Monogenic obesity is described as rare and severe early-onset obesity with abnormal feeding behavior and endocrine disorders."( Clément, K; Dubern, B; Huvenne, H; Poitou, C, 2016)
"Obesity is a major risk-factor for the development of insulin resistance, type 2 diabetes, and cardiovascular disease."( Davis, AI; Dedhia, N; Demidowich, AP; Yanovski, JA, 2016)
"Obesity is one of the major risk factors of metabolic syndrome, such as hypertension, hyperlipidemia, and diabetes."( Hosoi, T; Ozawa, K, 2016)
"Obesity is a serious health hazard with rapidly increasing prevalence in the United States."( Bollag, WB; Xie, D, 2016)
"Obesity is linked to a propensity to make risky decisions in experimental conditions analogous to everyday food choices."( Fernández-Aranda, F; Navas, JF; Perales, JC; Steward, T; Verdejo-García, A; Vilar-López, R, 2016)
"Obesity is associated with colorectal cancer (CRC)."( Anzelmi, F; Bordonaro, M; Cerra, C; Cho, Y; Gutierrez, L; Hooven, JT; Lazarova, DL; Russo, D, 2016)
"Obesity is associated with a notable risk for disease, including risk of cardiovascular disorders, type 2 diabetes mellitus (T2DM) and hypertension."( Cui, X; Gu, N; Guo, X; Ji, C; Pang, L; Shi, C; Yang, L; You, L; Zheng, W, 2016)
"The incidence of obesity is on the rise in most western countries and represents major risks to health."( Garrels, W; Hiebl, B; Jung, JS; Kielstein, H; Mattheis, L; Spielmann, J, 2016)
"Arthritis and obesity are common co-occurring conditions that can increase disability and the risk of adverse outcomes (e."( Barbour, KE; Boring, M; Helmick, CG; Hootman, JM; Pan, L; Qin, J, 2017)
"Obesity is one of the most prevalent chronic diseases worldwide, and dysregulated adipocyte function plays an important role in obesity-associated metabolic disorder."( Ha, H; Huh, JY; Jung, I; Miyata, T; Piao, L, 2016)
"Obesity is the result of a long-term positive energy balance in which caloric intake overrides energy expenditure."( Araujo, EP; Bobbo, V; De-Lima-Junior, JC; Fioravante, M; Morari, J; Moura, R; Nascimento, LF; Nogueira, G; Razolli, D; Rocha, GZ; Solon, C; Souza, GF; Velloso, LA, 2016)
"Obesity is a major health concern that increases the risk for insulin resistance, type 2 diabetes (T2D), and cardiovascular disease."( Aburasayn, H; Al Batran, R; Ussher, JR, 2016)
"Obesity is commonly associated with infertility in humans and other animals."( Anderson, GM; Grattan, DR; Inglis, MA; McEwen, HJ; Quennell, JH, 2016)
"Obesity is a chronic low-grade inflammatory condition associated with the elaboration of proinflammatory cytokines and adipokines from adipose tissue."( Diebel, LN; Diebel, ME; Liberati, DM, 2016)
"Obesity is prevalent worldwide and is a major risk factor for the development and progression of kidney disease."( Chen, M; Gao, B; Ji, A; Li, H; Li, M; Li, Y; Ma, C; Wang, S; Wu, D; Yao, L, 2016)
"Obesity is currently considered to be the most frequent metabolic disease worldwide, not only in developed but also in developing countries."( Fajfr, M; Fajfrová, J; Husarová, M; Krutišová, P; Pavlík, V; Psutka, J, 2016)
"Chronic obesity is a known risk factor for metabolic syndrome."( Hirakawa, T; Motojima, K; Nakadate, K; Tanaka-Nakadate, S, 2016)
"Obesity is a worldwide threat to public health in modern society, which may result from leptin resistance and disorder of thermogenesis."( Gao, Y; Hu, ZB; Huang, F; Lan, YY; Qin, LY; Shi, HL; Wu, H; Wu, XJ; Zhang, BB, 2016)
"Obesity is strongly linked to metabolic complications, including type 2 diabetes mellitus and hyperlipidemia."( Bo, P; Fang, P; Gu, X; Shi, M; Yu, M; Zhang, Z; Zhu, Y, 2016)
"Obesity is characterized by hyperleptinemia and central leptin resistance."( Choi, JW; Feng, X; Ibi, D; Lee, J; Liu, J; Mucka, P; Ozcan, U; Salazar Hernández, MA, 2016)
"Obesity is a risk factor for developing severe influenza virus infection, making vaccination of utmost importance for this high-risk population."( Hertz, T; Johnson, C; Karlsson, EA; Krammer, F; Mehle, A; Schultz-Cherry, S, 2016)
"Obesity is a worldwide epidemic, and associated pathologies, including type 2 diabetes and cardiovascular alterations, are increasingly escalating morbidity and mortality."( Carvalho, RA; Jarak, I; Palmeira, CM; Rolo, AP; Teodoro, JS, 2016)
"Obesity is an important risk factor for primary and secondary PTC in post-pubertal children."( Phillips, PH; Rook, BS, 2016)
"Obesity is a low-grade chronic inflammatory state representing an important risk factor for colorectal cancer (CRC)."( Conti, L; D'Archivio, M; De Meo, S; Del Cornò, M; Donninelli, G; Gessani, S; Giammarioli, S; Masella, R; Pennestrì, F; Persiani, R; Scazzocchio, B; Silecchia, G; Varano, B; Varì, R, 2016)
"Obesity is associated with adipose tissue dysfunction and multi-organ insulin resistance."( Franczyk, MP; Imai, S; Kelly, SC; Moseley, AC; Qi, N; Stromsdorfer, KL; Yamaguchi, S; Yoon, MJ; Yoshino, J, 2016)
"Obesity is a major risk factor driving the global type II diabetes pandemic."( Academia, EC; Ashe, TD; Carr, KL; Dastidar, SG; Del Greco, E; Kaplowitz, BS; Kennedy, BK; La Spada, AR; Martinez, LL; Rodriguez, AA; Sitzmann, JM; Tsai, SY; Viray, CM, 2016)
"Obesity is a potent predictor of cardiovascular disease and associated risk factors, including hypertension."( Sullivan, JC; Taylor, LE, 2016)
"Obesity is a risk factor for asthma, and obese asthmatics have lower disease control and increased symptom severity."( Mota-Pinto, A; Muc, M; Padez, C, 2016)
"Obesity is a major risk factor for the development of chronic kidney disease, even independent of its association with hypertension, diabetes, and dyslipidemia."( Alam, N; Liu, S; Prusky, GT; Seshan, SV; Soong, Y; Szeto, HH, 2016)
"Obesity is associated with vitamin D deficiency."( Abbas, MA, 2017)
"Obesity is a significant health problem in the United States (an estimated 69% of U."( Isaacs, D; Prasad-Reddy, L; Srivastava, SB, 2016)
"Obesity is a major public health concern and it is essential to identify effective treatments and preventative strategies to stop continued increases in obesity rates."( Baum, JI; Bottje, W; Davis, G; Dridi, S; Shouse, SA; Smith, D; Washington, TA, 2016)
"Obesity is a global health problem and impacts negatively on levels of testosterone and quality of sperm production."( Atanassova, N; Kiess, W; Klöting, N; Savchuk, I; Söder, O; Spröte, C; Svechnikov, K; Wagner, IV, 2016)
"Obesity is associated with chronic low-grade inflammation that drives the development of metabolic diseases, including non-alcoholic fatty liver disease (NAFLD)."( Kleemann, R; Kooistra, T; Liang, W; Morrison, MC; Mulder, P; van Bockel, JH; Verschuren, L; Wielinga, PY, 2016)
"Obesity is a state of positive energy balance where excess white adipose tissue accumulates to the detriment of metabolic health."( Andreu, I; Buchwalder, C; Gray, SL; Häfeli, UO; Leung, D; Nicholson, KE; Saatchi, K; Schmitt, V; Tod, SE, 2017)
"Obesity is a worldwide problem predisposing to type 2 diabetes mellitus (T2DM), hypertension, cardiovascular disease, cancer and other comorbidities."( Chan, P; Hu, M; Liu, ZM; Tomlinson, B; Zhang, Y, 2016)
"Obesity is the most common nutritional disorder and is associated with significant comorbidities such as dyslipidemia, atherosclerosis and type 2 diabetes."( Bouzenna, H; Dhibi, S; ElFeki, A; Hfaiedh, N; Ncib, S; Samout, N, 2016)
"Allergic asthma and obesity are the leading health problems in the world."( Castillo, EF; Liu, M; Luo, Y; Yang, XO; Zhang, X; Zheng, H, 2016)
"Diet-induced obesity is known to impair male reproduction and may aggravate the male reproductive toxicity of the food contaminant acrylamide."( Brunborg, G; Danielsen, T; Duale, N; Gutzkow, KB; Hofer, T; Instanes, C; Lindeman, B; Olsen, AK; Shahzadi, S; Steffensen, IL; Törnqvist, M; von Stedingk, H, 2016)
"Obesity is a worldwide pandemic associated with high incidence of cardiovascular disease."( Adorni, CS; Cicogna, AC; da Silva, DC; de Campos, DH; de Deus, AF; de Oliveira, SM; de Tomasi, LC; Okoshi, K; Padovani, CR; Sant'Ana, PG; Vileigas, DF, 2016)
"Obesity is related to an increased risk of gastric cardia cancer."( Huang, YK; Kang, WM; Liu, YQ; Ma, ZQ; Yu, JC; Zhou, L, 2016)
"Obesity is associated with reduced testosterone and worsened erectile and sexual function in men."( Brinkworth, GD; Clifton, PM; Lutze, J; Martin, S; Moran, LJ; Noakes, M; Stuckey, B; Wittert, GA; Wycherley, TP, 2016)
"Obesity is a chronic disease characterized by excessive accumulation of body fat and the presence of metabolic disorders such as insulin resistance."( Cruz, KJ; de Oliveira, AR; Marreiro, DD; Morais, JB; Severo, JS, 2017)
"Obesity is associated with metabolic tissue infiltration by monocyte-derived macrophages."( Bilan, PJ; Chan, KL; Ducos, A; Jacobson, MR; Klip, A; Mejdani, M; Niu, W; Pillon, NJ; Zhang, S, 2016)
"Obesity is viewed as a serious public health problem."( Cho, HY; Lee, HS; Lee, JH; Lee, SH; Lee, SJ; Lim, WC, 2016)
"Obesity is a major contributory factor of morbidity and mortality."( Avcilar, T; Celik, N; Deyneli, O; Guney, AI; Kasimay Cakir, O; Kaspar, EC; Kirac, D; Kurtel, H; Yazici, D, 2016)
"Overweight/obesity is associated with significant morbidity, mortality and costs."( Finer, N; James, WP; Leach, R; Lobstein, T; Morris, S; Trimmer, C; Zomer, E, 2017)
"Diabetes and obesity are associated with inflammasome-mediated low-grade, chronic inflammation that may induce pancreatic beta-cell dysfunction and apoptosis."( Brethauer, SA; Dan, O; Dinischiotu, A; Huang, H; Kirwan, JP; Mocanu, AO; Mulya, A; Schauer, PR, 2016)
"Obesity is associated with greater food-evoked responsivity in the ventral and dorsal striatum, and overweight is associated with greater monetary-evoked responsivity in the ventral striatum, the amygdala, and the medial frontal cortex."( Navas, JF; Soriano-Mas, C; Verdejo-García, A; Verdejo-Román, J; Vilar-López, R, 2017)
"Dietary obesity is usually linked with hypothalamic leptin resistance, in which the primary impact is an interference in the homeostatic control of body weight and appetite."( Aragonès, G; Ardid-Ruiz, A; Bladé, C; Ibars, M; Muguerza, B; Suárez, M, 2017)
"Aging and obesity are associated with raised oxidative stress and a reduction of nitric oxide (NO) bioavailability, with subsequent decline in insulin sensitivity and endothelial function."( Ashor, AW; Brandt, K; Chowdhury, S; Ishaq, A; Mathers, JC; Oggioni, C; Qadir, O; Saretzki, G; Siervo, M, 2016)
"Overweight and obesity are growing health-related problems worldwide, and it is currently the most prevalent nutritional disorder among children and adolescents."( Anil, S; Bhat, SS; Chandru, TP; Hegde, KS; Kottayi, S; Peedikayil, FC, 2016)
"Obesity is a major risk factor for several conditions including atherosclerotic disease, metabolic syndrome, and upper airway dysfunction."( Ali-Dinar, T; Lang, JE, 2017)
"Obesity is an increasing problem and high-protein intake early in life seems to increase later risk of obesity."( Larnkjær, A; Lind, MV; Michaelsen, KF; Mølgaard, C, 2017)
"Obesity is associated with an increased prevalence rate of a high non-HDL-C level in children aged 9-11 years."( Deng, YB; He, N; Liu, D; Su, Q; Wang, HM; Yin, H; Yu, D; Zhou, ZM, 2016)
"Obesity is exponentially increasing regardless of its preventable characteristics."( Chung, HJ; Hong, ST; Kim, HJ; Sharma, SP, 2016)
"Obesity is associated with both increased SNS electrical activity and plasma norepinephrine."( Milic, M; Ziegler, MG, 2017)
"Obesity is a global epidemic that contributes to a number of health complications including cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders."( Dwoskin, LP; Narayanaswami, V, 2017)
"Obesity is one of the greatest public health problems."( Araniti, F; Conforti, F; Marrelli, M; Statti, GA, 2016)
"Obesity is a global health concern."( Chen, HJ; Cheng, AC; Chou, SC; Ho, CT; Kalyanam, N; Lin, YH; Pan, MH; Tung, YC, 2016)
"Obesity is set to overtake tobacco smoking in many countries as the primary cause of several high-cost diseases."( Bauld, L; Breier, BH; Glover, M, 2017)
"The prevalence of obesity is escalating alarmingly worldwide, and it is now becoming a rapidly growing epidemic in developing countries."( Jayawardena, R; Rathnayake, KM; Silva, K, 2016)
"Obesity is a rising issue especially in the United States that can lead to heart problems, type II diabetes, and respiratory problems."( Abbott, RD; Borowsky, FE; Kaplan, DL; Wang, RY; Zieba, A, 2017)
"Obesity is associated with tissue inflammation which is a crucial etiology of insulin resistance."( Buffington, DA; Humes, HD; Johnston, KA; Westover, AJ, 2016)
"Obesity is both a cause and a possible consequence of obstructive sleep apnoea (OSA), as OSA seems to affect parameters involved in energy balance regulation, including food intake, hormonal regulation of hunger/satiety, energy metabolism and physical activity."( Shechter, A, 2016)
"Obesity is caused by an imbalance between energy intake (EI) and energy expenditure (EE), and thus negative energy balance is required to bring about weight loss, which can be achieved by either decreasing EI or increasing EE."( Harpaz, E; Tamir, S; Weinstein, A; Weinstein, Y, 2017)
"Obesity is now recognized as a state of chronic low-grade inflammation and is called as metabolic inflammation."( Ikeda, S; Matsui, J; Miyahisa, I; Suzuki, H; Takagahara, S; Tamura, YO; Watanabe, M; Yashiro, H, 2016)
"Obesity is not apparently associated with impaired GLP-1 secretion."( Feinle-Bisset, C; Horowitz, M; Jones, KL; Marathe, CS; Rayner, CK; Standfield, S; Trahair, LG, 2017)
"Obesity is associated particularly with post-menopausal breast cancer."( Olver, IN, 2016)
"Since obesity is associated with central and peripheral metabolic dysfunction we sought to determine if GBC is altered in obesity."( Abdallah, C; Cecchi, G; Geha, P; Small, DM; Todd Constable, R, 2017)
"Given that obesity is now a global "pandemic" it is vital that we evaluate the effect of obesity on trimethoprim-sulfamethoxazole concentrations."( Gumbo, T; Hall, RG; Leff, RD; Meek, C; Pasipanodya, JG; Swancutt, M, 2016)
"Obesity is one of the major public health challenges worldwide."( Balaskó, M; Czimmer, J; Füredi, N; Garami, A; Hegyi, P; Márta, K; Mátrai, P; Mikó, A; Párniczky, A; Pétervári, E; Rostás, I; Solymár, M; Szabó, I; Tenk, J; Zsiborás, C, 2016)
"Obesity is associated with an increased risk of estrogen-dependent breast cancer after menopause."( Brown, KA; Simpson, ER; Zahid, H, 2016)
"Obesity is a one of the main global public health problems associated with chronic diseases such as coronary heart disease, diabetes and cancer."( Bouzenna, H; Elfeki, A; Ettaya, A; Hfaiedh, N; Ncib, S; Samout, N, 2016)
"Obesity is associated with increased classically activated M1 adipose tissue macrophages (ATMs) and decreased alternatively activated M2 ATMs, both of which contribute to obesity-induced inflammation and insulin resistance."( Cao, Q; Shi, H; Wang, X; Xue, B; Yu, L, 2016)
"Obesity is also subject to epigenetic regulation."( Coleman, WB, 2016)
"Childhood obesity is related to a cascade of neuroendocrine inflammatory changes."( Andrade, CA; Camargos, AC; Coimbra, CC; Júnior, AL; Lacerda, AC; Leite, HR; Mendonça, VA; Neves, CD; Oliveira, KS; Oliveira, MX; Rocha-Vieira, E; Tossige-Gomes, R; Vieira, ÉL, 2016)
"Obesity is a leading cause of cardiovascular disease."( Louis, XL; Netticadan, T; Perera, D; Raj, P; Taylor, CG; Thandapilly, SJ; Yamanagedara, P; Zahradka, P, 2017)
"Diabetes and obesity are already recognized as potential risk factors for nephrolithiasis, especially for uric acid stones."( Angelini, C; Badalamenti, S; Gambaro, G; Maringhini, S; Spatola, L, 2017)
"Obesity is associated with kidney defects."( Bogdański, P; Jakubowski, H; Karolkiewicz, J; Madry, E; Musialik, K; Ratajczak, M; Skrypnik, D; Szulińska, M; Walkowiak, J, 2016)
"Obesity is assumed to be a major cause of human essential hypertension; however, the mechanisms responsible for weight-related increase in blood pressure (BP) are not fully understood."( Alenina, N; Araújo, RC; Bader, M; Carmona, AK; Chagas, JR; Hilzendeger, AM; Morais, RL; Mori, MA; Nakaie, CR; Pesquero, JB; Todiras, M; Visniauskas, B, 2017)
"Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease."( Siew-Moi, P; Wan-Loy, C, 2016)
"Obesity is a major public health problem and great risk for not only cardiovascular diseases but also cancer, musculoskeletal, and gynecological diseases."( Baltaci, D; Deler, MH; Ermis, F; Iliev, D; Turker, Y; Velioglu, U, 2017)
"Maternal obesity is growing in prevalence and is associated with increased morbidity and mortality for both mother and child."( Barrett, HL; Dekker Nitert, M; Gallo, LA, 2017)
"Obesity is a major public health concern that involves an interaction between genetic susceptibility and exposure to environmental cues (e."( Gilbert-Diamond, D; Heatherton, TF; Kelley, WM; Rapuano, KM; Sargent, JD; Zieselman, AL, 2017)
"Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms."( Blankenberg, S; Blettner, M; Kempf, T; Kuulasmaa, K; Lackner, KJ; Michal, M; Munzel, T; Ohdah, S; Ojeda, F; Pfeiffer, N; Salomaa, V; Schnabel, RB; Schwarzl, M; Sinning, C; Westermann, D; Wild, PS; Wollert, KC; Zeller, T, 2017)
"The incidence of obesity is rapidly escalating and has reached epidemic proportions."( Henry, BA, 2017)
"Obesity is associated with chronic inflammation, which contributes to insulin resistance and type 2 diabetes mellitus."( Ballantyne, CM; Wu, H, 2017)
"Childhood obesity is commonly associated with early signs of endothelial dysfunction, characterized by impairment of insulin signaling and vascular Nitric Oxide (NO) availability."( Bologna, G; Chiarelli, F; Cordone, VGP; de Giorgis, T; Di Pietro, N; Di Silvestre, S; Lanuti, P; Marcovecchio, ML; Mohn, A; Pandolfi, A, 2017)
"We conclude that obesity is one identifiable risk factor for MSP in middle-aged women."( Arteaga, E; Barón, G; Bencosme, A; Benítez, Z; Blümel, JE; Bravo, LM; Calle, A; Chedraui, P; Espinoza, MT; Flores, D; Gómez, G; Hernández-Bueno, JA; Lima, S; Martino, M; Mezones-Holguín, E; Monterrosa, A; Mostajo, D; Ojeda, E; Onatra, W; Sánchez, H; Tserotas, K; Vallejo, MS; Witis, S; Zúñiga, MC, 2017)
"Obesity is a major health problem worldwide, for which preventive and therapeutic means are still needed."( Afsartala, Z; Amoli, MM; Ebrahim-Habibi, A; Larijani, B; Mahmoudi, M; Mojbafan, M; Yaghmaei, P, 2017)
"Furthermore, obesity is a preventable state, and the specific activation of adenosine receptors could aid in the prevention of obesity."( Chiarello, DI; Gutierrez, J; Leiva, A; Pardo, F; Salsoso, R; Sobrevia, L; Toledo, F; Villalobos-Labra, R, 2017)
"Obesity is a major health problem in modern society because their progression is always associated with many health issues."( Liu, CL; Niu, HM, 2017)
"Obesity is a well-established cause of postmenopausal breast cancer."( Berkey, CS; Chen, WY; Colditz, GA; Eliassen, AH; Hankinson, SE; Rosner, B; Toriola, AT; Willett, WC, 2017)
"Obesity is associated with lower vitamin D levels compared with normal weight subjects, and if levels are not replaced prior to bariatric surgery, this can increase fracture risk as bone density typically falls post-operatively."( Abbas, A; Barth, JH; Chandrajay, D; King, RJ; Orme, SM, 2017)
"Obesity is an established risk factor for the development of pancreatic ductal adenocarcinoma (PDAC)."( Chen, Y; Cornwell, M; Crawford, SE; Ding, X; Grace, SA; Hou, P; Lai, JP; Meeks, MW; Rutgers, JK, 2017)
"Childhood obesity is a major public health problem that has grown to epidemic proportions throughout the world."( Kiess, W; Shalitin, S, 2017)
"Excess weight and obesity are severe public health threats worldwide."( Hong, F; Jia, L; Jin, X; Wang, J; Wang, S; Xu, P; Xue, T; Zhai, Y, 2017)
"The prevalence of obesity is surging in an alarming rate all over the world."( Brownell, L; Hong, M; Hyun, EJ; Jia, Q; Jiao, P; Kim, HJ; Kim, MR; Lee, YC; Nam, JB; Yimam, M, 2017)
"Obesity is associated with impaired immune defences and chronic low levels of inflammation and oxidation."( De la Fuente, M; Díaz, LE; Gheorghe, A; Hernandez, O; Hunsche, C; Marcos, A, 2018)
"Obesity is a chronic disease universally defined as an excess of adipose tissue resulting in body mass index (BMI) > 30."( Curry, SA, 2017)
"Obesity is a pandemic, gateway disease that has thrived in modern, sedentary, high calorie-eating societies."( Ayala, JE; Brown, JD; Karimian Azari, E, 2017)
"Obesity is one of the most important metabolic disorders of this century and is associated with a cluster of the most dangerous cardiovascular disease risk factors, such as insulin resistance and diabetes , dyslipidemia and hypertension , collectively named Metabolic Syndrome."( da Silva, IV; Soveral, G, 2017)
"Obesity is an independent risk factor for cardiovascular morbidity and mortality due to atherothrombotic events and represents a group of patients who are in need of optimized antithrombotic therapy."( Monte, SV; Norgard, NB, 2017)
"Obesity is associated with prothrombotic changes which have been well-characterised and include increased levels of plasminogen activator-1, von Willebrand factor, fibrinogen and evidence of increased coagulation and platelet activation; however, these changes do not seem to account for all the increased risk."( Hunt, BJ, 2017)
"Obesity is defined as an abnormal increase in white adipose tissue (WAT) and is a major risk factor for type 2 diabetes and cardiovascular disease."( Burnett, JC; Cannone, V; Glöde, A; Gnad, T; Kilic, A; Naumann, J; Pfeifer, A, 2017)
"Obesity is a global disease, affecting nearly half a billion people."( Olver, CS; Pannone, SC; Radakovich, LB; Santangelo, KS; Truelove, MP, 2017)
"As obesity is a complex inflammatory disease, there is a need to determine whether routine medical screening tests may indicate, or be influenced by, its presence."( Olver, CS; Pannone, SC; Radakovich, LB; Santangelo, KS; Truelove, MP, 2017)
"RETRACTED: Obesity is a significant risk factor for acute respiratory distress syndrome."( Guo, Z; Kallen, CB; Li, J; Naik, UP; Romero, F; Shah, D; Summer, R; Sun, J, 2017)
"Obesity is a worldwide medical problem resulting in serious morbidity and mortality involving differentiation of pre-adipocytes into mature adipocytes (adipogenesis)."( Apdik, H; Bayrak, OF; Demirci, S; Doğan, A; Gulluoglu, S; Gusev, O; Nikerel, E; Rizvanov, AA; Şahin, F; Tuysuz, EC, 2017)
"Obesity is accompanied with systemic inflammation and pre-conditions to severe alterations in liver environment and functions."( Cebula, M; Gaur, P; Hauser, H; Hillebrand, U; Riehn, M; Wirth, D, 2017)
"Obesity is an established risk factor for many diseases including intestinal cancer."( Guo, X; Li, J; Liu, Z; Tang, R; Wood, RJ; Zeng, H; Zhang, G, 2017)
"Obesity is characterized by chronic low-grade inflammation driven by activation and tissue infiltration of circulating leukocytes."( Barry, JC; Durrer, C; Jung, ME; Little, JP; Simtchouk, S, 2017)
"Maternal obesity is a risk factor for offspring obesity."( Kisliouk, T; Marco, A; Meiri, N; Tabachnik, T; Weller, A, 2017)
"Obesity is caused by an imbalance between energy intake, i."( Asarian, L; Geary, N; Leeners, B; Tobler, PN, 2017)
"The incidence of obesity is rising at an alarming rate throughout the world and is becoming a major public health concern with incalculable social and economic costs."( Choi, J; Kim, KJ; Koh, EJ; Lee, BY, 2017)
"Obesity is often accompanied by decreases in the proportion of skeletal muscle slow-twitch fibers and insulin sensitivity."( Chen, K; Gong, X; Gu, Y; Lang, H; Mi, M; Ran, L; Wang, X; Zhou, M; Zhou, Q; Zhu, J, 2017)
"Childhood obesity is associated with advanced bone age (BA)."( Ballieux, BEPB; de Groot, CJ; Kroon, HM; Rings, EHHM; van den Akker, ELT; van den Berg, A; Wit, JM, 2017)
"Although obesity is well established in hamsters, studies using diets with high levels of simple carbohydrate associated with lipids are necessary to assess the impact of this type of food in the body."( Dias, SRC; Faria, AMC; Furtado, LFV; Jordania da Silva, V; Maioli, TU; Quintão Silva, MDG; Rabelo, ÉML; Serafim, LR, 2017)
"Nowadays, obesity is seriously increasing in most of the populations all over the world, and is associated with the development and progression of high-mortality diseases such as type-2 diabetes mellitus (T2DM) and its subsequent cardiovascular pathologies."( Egido, J; González, N; González-Bris, A; Lorenzo, Ó; Moreno-Villegas, Z, 2017)
"Obesity is associated with chronic inflammation and liver steatoses."( Liu, Y; Rui, L; Shen, H; Sheng, L; Xiong, Y, 2017)
"Obesity is a major public health problem."( Azaïs, H; Deruelle, P; Ghesquiere, L; Hanssens, S; Leroy, A, 2017)
"Obesity is a global health problem even among pregnant women."( Ducza, E; Gaspar, R; Hajagos-Tóth, J; Samavati, R; Vari, SG, 2017)
"BACKGROUND Obesity is known as a major risk factor for postoperative vein thrombosis."( Gudaityte, R; Kupcinskas, J; Kupcinskiene, K; Macas, A; Maleckas, A; Petereit, R; Trepenaitis, D, 2017)
"The prevalence of obesity is increasing worldwide."( Chi, MH; Guo, L; Huang, X; Zhang, XM; Zhang, YB, 2017)
"Obesity is a growing public health problem, which has now been considered as a pandemic non-communicable disease."( Feng, Q; Xiao, X; Zhang, Q; Zheng, J; Zheng, S, 2017)
"Obesity is closely associated with metabolic diseases including type 2 diabetes."( Choe, SS; Kim, JB; Park, YJ; Sohn, JH, 2017)
"Obesity is associated with multiple diseases, but it is unclear how obesity promotes progressive tissue damage."( Diehl, AM; Jewell, ML; Machado, MV; Michelotti, GA; Premont, RT; Swiderska-Syn, M; Xie, G, 2017)
"Obesity is a multifactorial, chronic disease that has proven difficult to treat."( Avena, NM; Benoit, SC; Conason, A; Davis, JF; Gearhardt, AN; Goldman, R; Ivezaj, V; Mitchell, JE; Ochner, CN; Saules, KK; Sogg, S; Steffen, KJ; Stice, E; Stoeckel, LE, 2017)
"Obesity is metabolic disorder that increases the risk of diabetes, heart disease, and other metabolic syndromes in human beings."( Ahmed, Z; Qadir, MI, 2017)
"Maternal obesity is associated with increased oxidative stress but decreased placental mitochondrial respiration and expression of mitochondrial electron transport chain (ETC) complexes I to V."( Ireland, KE; Maloyan, A; Myatt, L, 2018)
"Obesity is characterized by increased fat mass, as adipose tissue serves as a storage site for excess energy from food consumption."( Ahn, J; Choi, WH; Ha, TY; Jung, CH; Lee, H, 2017)
"Obesity is a major health threat that affects men and women equally."( Clemmensen, C; DiMarchi, RD; Finan, B; Hofmann, SM; Jall, S; Müller, TD; Neff, F; Sachs, S; Tschöp, MH, 2017)
"Hypertrophic obesity is associated with adipose tissue malfunctioning, leading to inflammation and insulin resistance."( Sorisky, A, 2017)
"Obesity is believed to be one of the major risk factors for cardiovascular disease in Western countries."( Inoue, Y; Kawai, M; Minai, K; Morimoto, S; Nagoshi, T; Ogawa, K; Ogawa, T; Tanaka, T; Tsutsumi, J; Yoshimura, M, 2017)
"Obesity is a multifactorial disorder with high heritability (50-75%), which is probably higher in early-onset and severe cases."( Argente, J; Bou de Pieri, F; Flores, R; González, JR; Martos-Moreno, GÁ; Pérez-Jurado, LA; Rodríguez-Santiago, B; Serra-Juhé, C, 2017)
"Obesity is associated with increased risk for infections and poor responses to vaccinations, which may be due to compromised B cell function."( Armstrong, M; Beck, M; Bridges, LC; Crouch, MJ; Gowdy, K; Guesdon, W; Karlsson, EA; Kosaraju, R; Milner, JJ; Neufer, PD; Reese, LR; Reisdorph, N; Schultz-Cherry, S; Shaikh, SR; Sullivan, EM; Teague, HL, 2017)
"Obesity is one of the independent risk factors for several health problems, leading to metabolic perturbations and for which analytical approaches i."( Abdel-Hamid, AZ; Ammar, NM; El Gendy, AN; El-Sheikh, NM; Farag, MA; Kholeif, TE; Metwally, NS, 2017)
"Obesity is a major cause of type 2 diabetes and may complicate type 1 diabetes."( Wilding, JPH, 2018)
"Obesity is a major risk factor for type 2 diabetes mellitus (T2DM)."( Awasthi, A; Hegde, DS; Rao N, K; Rao, CR, 2017)
"Obesity is associated with a low-grade inflammatory status that affects vascular function."( Algieri, F; Díaz-de-Cerio, E; Duarte, J; Galvez, J; Rodríguez-Nogales, A; Romero, M; Segura-Carretero, A; Verardo, V, 2017)
"Obesity is a global epidemic that affects 500 million people worldwide and is predicted to increase to one billion people by 2030."( Afolayan, AJ; Otang-Mbeng, W; Otunola, GA, 2017)
"Obesity is a large and growing public health concern, presenting enormous economic and health costs to individuals and society."( Bryan, AD; Gardiner, CK; Hutchison, KE; YorkWilliams, SL, 2017)
"Obesity is frequently accompanied with elevated leptin levels."( Huang, HF; Lin, XH; Ullah, K; Ur Rahman, T; Wang, H; Wu, DD; Yu, TT, 2017)
"Obesity is independently associated with limitations in lung mechanics with increased ozone dose."( Koman, PD; Mancuso, P, 2017)
"Obesity is associated with low-grade inflammation."( Becker, K; Ciardi, C; Fuchs, D; Gostner, JM; Mangge, H; Strasser, B, 2017)
"Hence, abdominal obesity is associated with vascular endothelial dysfunction and reduced nitric oxide (NO) availability."( Engin, A; Engin, AB, 2017)
"Obesity is a disorder of body weight regulatory systems characterized by an accumulation of excess body fat."( Akter, R; Nessa, A; Sarker, D; Yesmin, M, 2017)
"Obesity is characterized by a massive infiltration of the adipose tissue by macrophages."( Kim, M; Kim, YS; Song, K, 2017)
"Obesity is associated with an increased risk of chronic kidney diseases and the conventional treatment with renin-angiotensin-aldosterone system (RAAS) inhibitors is not enough to prevent renal injury and prolong the progression of disease."( Bi, Y; Meng, R; Shen, S; Zhu, D, 2017)
"Obesity is a global public health concern and may lead to a variety of complications."( Gao, C; Li, S; Song, L; Xie, H; Xu, G; Zhang, N; Zhao, C; Zhao, W; Zhao, Y, 2017)
"Obesity is associated with numerous metabolic and inflammatory disorders."( Farhangi, MA; Hajiluian, G; Mesgari-Abbasi, M; Nameni, G, 2017)
"The idea that obesity is a neurobiological disease rather than a metabolic disorder, is the basis of the study."( Avsar, O; Genc, E; Kuskucu, A; Sancak, S, 2017)
"Obesity is an important contributor to insulin resistance, and although the understanding of this relationship has improved in recent years, the mechanism of obesity-induced insulin resistance is not completely understood."( Ding, M; Dou, X; Du, SY; Guo, L; Huang, HY; Liu, Y; Peng, WQ; Qian, SW; Tang, QQ; Wei, XB; Zhou, SR, 2017)
"Further, obesity is associated with lower circulating nutrients, though the reason is unclear."( Baer, DJ; Chen, TY; Ferruzzi, MG; Gebauer, SK; Ho, L; Novotny, JA; Pasinetti, GM; Terekhov, AI, 2017)
"Human obesity is associated with altered incretin secretion and elevated endocannabinoid levels."( Carlson, OD; Chia, CW; Egan, JM; González-Mariscal, I; Liu, DD; Santa-Cruz Calvo, S, 2017)
"Obesity is considered to be a low-grade chronic inflammatory process, which is associated with cardiovascular and metabolic diseases."( Astiazarán-García, H; Domínguez Avila, JA; Ezquerra-Brauer, JM; González-Aguilar, GA; Loarca-Piña, G; Robles-Sánchez, M; Salazar-López, NJ, 2017)
"Diet-induced obesity is associated with NOS uncoupling, which may in part contribute to the associated cardiovascular dysfunction due to exacerbated PKG Iα disulfide oxidation to the disulfide state."( Eaton, P; Rudyk, O, 2017)
"Obesity is a serious, chronic, relapsing disease of energy regulation, with strong genetic and early-life environmental determinants."( Dixon, J; Lee, PC, 2017)
"Obesity is associated with elevated circulating leptin levels and hypothalamic leptin resistance."( Bochenek, ML; Gogiraju, R; Hubert, A; Münzel, T; Schäfer, K; Schütz, E, 2017)
"Obesity is the largest and fastest growing public health catastrophe in the world affecting both adults and children with a prevalence impacting more than one-third of United States (US) adult population."( Brownell, L; Hong, M; Jia, Q; Jiao, P; Kim, HJ; Kim, MR; Lee, YC; Nam, JB; Yimam, M, 2017)
"Obesity is associated with numerous health problems, particularly metabolic and cardiovascular complications."( Al-Safi Ismail, AA; Al-Tahami, BAM; Rasool, AHG; Sanip, Z; Shihabudin, TMT; Singh, TSP; Yusoff, Z, 2017)
"Obesity is associated with dysregulated lipid metabolism and adipokine secretion."( Fenton, JI; Jones, AD; Pickens, CA; Vazquez, AI, 2017)
"Obesity is one of the most serious public health problem worldwide."( Aksoy, E; Bostanci, EB; Dalgic, T; Kadri Colakoglu, M; Oter, V; Ozdemir, Y; Ozer, I; Ozogul, Y, 2017)
"Obesity is a strong risk factor for obstructive sleep apnea, a disease characterized by periodic upper airway occlusion during sleep."( Imayama, I; Prasad, B, 2017)
"Obesity is caused by an imbalance between energy intake and energy expenditure."( Murakami, S, 2017)
"Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA)."( Clish, CB; DuBois, CD; Freinkman, E; Hitchcock, DS; Kalaany, NY; Lenehan, PJ; Lin, L; Mino-Kenudson, M; Morales-Oyarvide, V; Stylopoulos, N; Torres, EM; Tsai, PY; Wolpin, BM; Zaytouni, T, 2017)
"Obesity is a multifactorial disease characterized by the abnormal or excessive fat accumulation, which is caused by an energy imbalance between consumed and expended calories."( Arbo, BD; Benetti, F; Cecconello, AL; Czarnabay, D; Niches, G; Ribeiro, MF; Zanini, P, 2017)
"Obesity is damaging the lives of more than 300 million people worldwide and maintaining a healthy weight using popular weight loss tactics remains a very difficult undertaking."( Badgaiyan, RD; Baron, D; Blum, K; Braverman, ER; Demetrovics, Z; Febo, M; Gold, MS; Modestino, EJ; Thanos, PK; Wang, GJ, 2018)
"Obesity is a major risk for hypertension."( Dong, Q; Gao, F; Liang, X; Su, F; Tian, F; Wang, S; Xing, W; Zhang, H, 2017)
"Both diabetes and obesity are components of the metabolic syndrome, and are also risk factors for nonalcoholic fatty liver disease (NAFLD)."( Alazawi, W; Cho, W; Shetty, A; Syn, WK, 2017)
"Hypothalamic obesity is a severe condition without any effective therapy."( Alegre-Maller, ACP; Araújo, ACF; Balbo, SL; Barbosa-Sampaio, HC; Bonfleur, ML; Boschero, AC; Cantelli, KR; Ribeiro, RA; Soares, GM, 2017)
"Obesity is associated with a loss of insulin-sensitivity and systemic dysglycemia, resulting in Type 2 diabetes, however the molecular mechanisms underlying this association are unclear."( Cao, L; Gunasekar, SK; Mishra, A; Sah, R; Xie, L; Zhang, Y, 2017)
"Obesity is clearly associated with an increased risk of breast cancer in postmenopausal women."( Beaudoin, MS; Connor, MK; Sauvé, OS; Theriau, CF; Wright, DC, 2017)
"Obesity is strongly associated with insulin resistance (IR), along with mitochondrial dysfunction to metabolically active tissues and increased production of reactive O2 species (ROS)."( Gou, X; Lin, D; Lucas, EA; O'Hara, C; Ojo, B; Peterson, SK; Simenson, AJ; Smith, BJ; Wu, L, 2017)
"Obesity is a major risk factor for the development of diabetes, insulin resistance, dyslipidemia, cardiovascular disease and other related metabolic conditions."( Collazo, J; Pervin, S; Singh, R; Singh, V; Tucker, A, 2017)
"Obesity is associated with an increased risk of type 2 diabetes and cardiovascular complications."( Angelucci, E; Bonadonna, RC; Cianfarani, S; Consoli, A; Davì, G; Di Castelnuovo, A; Federico, V; Guagnano, MT; Leo, M; Maccarone, MT; Manzoli, L; Santilli, F; Sborgia, C; Simeone, PG; Tartaro, A, 2017)
"Obesity is one of the most serious public health problems in the 21st century that may lead to many comorbidities such as type-2 diabetes, cardiovascular diseases, and cancer."( Gu, Z; Liu, Q; Qiang, L; Wang, J; Yu, J; Yu, S; Zhang, Y, 2017)
"Obesity is now an accepted risk factor for breast cancer in postmenopausal women, particularly for the hormone-dependent subtype of breast cancer."( Brown, KA; Gérard, C, 2018)
"Obesity is a main risk factor for the development of hepatic insulin resistance and it is accompanied by adipocyte hypertrophy and an elevated expression of different adipokines such as autotaxin (ATX)."( Fayyaz, S; Gulbins, E; Haubold, K; Japtok, L; Kleuser, B; Schulz, TJ; Schumacher, F; Völler, H; Wigger, D, 2017)
"Obesity is related to greater alveolar bone loss and an accentuated local inflammatory response, which may be reflected in the clinical severity of periodontitis and dental loss."( de Toledo, BEC; Ervolino, E; Favero, LFV; Garcia, VG; Longo, M; Martins, AT; Pires, JR; Ribeiro, FS; Spolidorio, LC; Theodoro, LH; Zuanon, JAS; Zuza, EP, 2018)
"The prevalence of obesity is increasing in all countries, becoming a substantial public health concern worldwide."( Cano-Sancho, G; La Merrill, MA; Salmon, AG, 2017)
"Obesity is reported to be a chronic low-grade inflammatory state."( Jing, Y; Li, D; Li, Q; Li, R; Wu, F; Yang, L, 2018)
"Maternal obesity is a risk factor for chorioamnionitis prior to labor onset."( Chiossi, G; Costantine, MM; Discacciati, A; Hadley, EE; Munn, MB; Pacheco, LD; Saade, GR, 2019)
"Childhood obesity is associated with renal diseases."( Alejandre Alcazar, MA; Appel, S; Dinger, K; Dötsch, J; Hucklenbruch-Rother, E; Janoschek, R; Kasper, P; Köth, J; Matthes, J; Mohr, J; Vohlen, C, 2017)
"Obesity is a major public health problem, which, like many forms of addiction, is associated with an elevated tendency to choose smaller immediate rather than larger delayed rewards, a response pattern often referred to as excessive delay discounting."( Bortolato, M; Fowler, SC; Hale, L; Hudnall, JL; Jarmolowicz, DP; Lemley, SM; Sofis, MJ, 2017)
"Obesity is associated with a greater risk of prostate cancer mortality."( deGraffenried, LA; Galván, GC; Johnson, CB; Jolly, CA; Liss, MA; Price, RS, 2017)
"Obesity is the leading chronic disease affecting people of all ages."( Chao, PM; Chen, GC; Chen, WH; Tseng, KT, 2017)
"Obesity is associated with mitochondrial dysfunction in skeletal muscle."( Carroll, CC; Hoffman, N; Katsanos, CS; Kras, KA; Patel, SH; Roust, LR, 2017)
"Obesity is linked to iron deficiency systemically, but the effects of obesity on brain iron and its associated consequences, including neurodegenerative processes remain unexplored."( Aschner, M; Byrd, A; Erikson, KM; Han, J; Liu, L; Plummer, J, 2019)
"Obesity is a common chronic disease, and elevated serum uric acid has been suggested to be associated with obesity."( Chen, C; Chen, Q; Lu, R; Mao, Y; Yang, T; Zheng, R, 2017)
"Obesity is an important risk factor for sleep disorders."( Akbar, A; Ayaz, MM; Bari, AZ; Naheed, S; Saeed, S; Samad, N; Ullah, N; Yasmin, F; Zaman, A, 2017)
"Obesity is a global problem reaching epidemic proportions and can be explained by unhealthy eating and sedentary lifestyles."( Booth, C; Fox, E; Grol, M; Spronk, D, 2018)
"Obesity is associated with elevated intracellular nitric oxide (NO) production, which promotes nitrosative stress in metabolic tissues such as liver and skeletal muscle, contributing to insulin resistance."( Chen, S; Ding, WX; Kunz, RC; Lind, NRL; Orwig, A; Qian, Q; Stamler, JS; Xu, Y; Yang, L; Zhang, Z, 2018)
"Obesity is a health problem caused by a diet rich in energy and the sedentary lifestyle of modern societies."( Bermejo-Millo, JC; Boga, JA; Caballero, B; Coto-Montes, A; de Luxán-Delgado, B; Pérez-Martínez, Z; Potes, Y; Rubio-González, A; Solano, JJ; Vega-Naredo, I, 2018)
"Maternal obesity is a global health problem that increases offspring obesity risk."( Baker, PR; Boyle, KE; Dabelea, D; De La Houssaye, BA; Friedman, JE; Patinkin, Z; Shapiro, AL; Vanderlinden, L; Woontner, M, 2017)
"The prevalence of obesity is increasing at an alarming rate in the United States with 36."( Howell, GE; Kondakala, S; Lee, JH; Ross, MK, 2017)
"Obesity is a risk factor for vascular endothelial cell dysfunction characterized by low-grade, chronic inflammation."( Eguchi, E; Fujikura, Y; Funakubo, N; Ito, T; Kubo, M; Nagaoka, K; Ogino, K; Setiawan, H; Takemoto, K, 2018)
"Obesity is associated with poorer outcome for many cancers."( Cortez-Toledo, O; Dieli-Conwright, CM; Louie, SG; Mittelman, SD; Neely, M; Oberley, MJ; Orgel, E; Parmentier, JH; Pei, H; Sheng, X; Tucci, J, 2017)
"Essentials Obesity is a potential risk factor for development of thrombotic thrombocytopenic purpura (TTP)."( Geys, L; Hoylaerts, MF; Lijnen, HR; Roose, E; Rottensteiner, H; Scroyen, I; Tersteeg, C; Vanhoorelbeke, K, 2018)
"Obesity is a major worldwide health problem and is often associated with many metabolic diseases."( Chen, WX; Dong, J; Ji, FS; Li, HX; Tang, YM; Wang, M; Wang, SM; Yang, RY, 2018)
"Obesity is an energy imbalance condition, which is accompanied by metabolic and cardiovascular complications."( Akor-Dewu, MB; Ayo, JO; Ciroma, FL; Kana, MA; Kase, SN; Mohammed, A, 2017)
"Obesity is an independent risk factor for cardiovascular morbidity and mortality due to atherothrombotic events and represents a group of patients who are in need of optimized antithrombotic therapy."( Norgard, NB, 2018)
"Obesity is characterized by chronic low-grade, systemic inflammation, altered gut microbiota, and gut barrier disruption."( Chitrala, KN; Enos, RT; Ganewatta, MS; McCellan, J; Mehrpouya-Bahrami, P; Murphy, EA; Nagarkatti, M; Nagarkatti, P; Tang, C; Velazquez, KT, 2017)
"Obesity is an increasingly severe socioeconomic health issue worldwide."( Kasuga, H; Kimura, Y; Takabayashi, Y; Tsubota, T; Yamada, A, 2018)
"Obesity is a risk factor for asthma, especially nonallergic asthma."( Shore, SA, 2017)
"Abdominal obesity is associated with insulin resistance and with higher risks of metabolic syndrome and cardiovascular diseases, whereas general obesity is not."( Goh, VHH; Hart, WG, 2018)
"Obesity is a global health concern with rising prevalence that increases the risk of developing other chronic diseases."( Hutchinson, AL; Liddle, DM; Monk, JM; Power, KA; Robinson, LE; Wellings, HR, 2017)
"To study if obesity is a risk factor in elderly patients (>60 years) with aggressive B-cell lymphoma, the outcomes of 576 elderly patients treated with rituximab in the RICOVER-60 trial were analysed in a retrospective study with regard to body mass index (BMI) and gender."( Altmann, B; Hohloch, K; Loeffler, M; Pfreundschuh, M; Schmitz, N; Trümper, L; Zettl, F; Ziepert, M, 2018)
"However, whether obesity is associated with acute inflammatory pain is unknown."( Cao, CQ; Han, W; Hu, ZJ; Mao-Ying, QL; Mi, WL; Wang, YQ, 2018)
"Obesity is currently the most extended metabolic disturbance worldwide favoring the development of cardiometabolic alterations such as type 2 diabetes, hypertension, and dyslipidemia."( Catalán, V; Frühbeck, G; Gómez-Ambrosi, J; Rodríguez, A, 2018)
"Obesity is a high risk factor for diseases such as cardiovascular, metabolic syndrome and asthma."( Agrawal, A; Bahal, D; Bajaj, A; Gheware, A; Jaiswal, A; Mabalirajan, U; Maheswari, D; Panda, L; Pratap, K; Ram, A; Singh, VP, 2018)
"Obesity is associated with an increase in urinary albumin excretion during the course of pregnancy."( Dağ, ZÖ; Erdoğan, F; Sağsöz, N; Sayan, CD; Tulmaç, ÖB, 2018)
"Considering obesity is very common in the schizophrenic population, these data suggest that previous research may be under-estimating the severity of olanzapine's acute side effects."( Bush, ND; Peppler, WT; Townsend, LK; Wright, DC, 2018)
"Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance."( Barroso, A; Castellano, JM; Fernandois, D; Heras, V; Manfredi-Lozano, M; Pinilla, L; Roa, J; Ruiz-Pino, F; Sanchez-Garrido, MA; Tena-Sempere, M; Vazquez, MJ; Velasco, I, 2018)
"Obesity is a current global epidemic that has led to a marked increase in metabolic diseases."( Ho, CT; Lai, CS; Pan, MH; Wu, JC, 2018)
"Obesity is the main feature of a complex illness known as metabolic syndrome."( Amelio, D; Angelone, T; Beretta, G; Casacchia, T; Gelmini, F; Granieri, MC; Mazza, R; Pasqua, T; Rocca, C; Scavello, F; Spena, A; Statti, G; Toma, CC, 2019)
"Obesity is a risk factor for cancer incidence and cancer mortality."( Clements, VK; Figley, C; Long, R; Long, T; Ostrand-Rosenberg, S; Smith, DMC, 2018)
"Obesity is accompanied by metabolic alterations characterized by insulin resistance and cardiac lipotoxicity."( Bartolomé, MAV; Cachofeiro, V; Gallardo, I; Gutiérrez, B; Gutiérrez-Tenorio, J; Jurado-López, R; López-Andrés, N; Marín-Royo, G; Martínez-Martínez, E; Nieto, ML; Rial, E, 2018)
"Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life."( Lancho, C; Lancho, JL; Maia-Landim, A; Poblador, MS; Ramírez, JM, 2018)
"Obesity is linked to the onset of many diseases such as diabetes mellitus, cardiovascular diseases and cancer, among others."( Antunes, LM; Colaço, B; Martins, T; Oliveira, PA; Pires, MJ; Rosa, E; Venâncio, C, 2018)
"Obesity is a major global public health problem."( Jones, NS; McGrath, T; Murphy, KG, 2018)
"Obesity is a major driver of metabolic diseases such as nonalcoholic fatty liver disease, certain cancers, and insulin resistance."( Bai, L; Du, J; Gan, M; Jiang, A; Jiang, Y; Jin, L; Li, M; Li, X; Ma, J; Shen, L; Tan, Z; Tang, G; Wang, J; Xu, Y; Yang, Q; Zhang, P; Zhang, S; Zhao, X; Zhu, L, 2018)
"Obesity is a growing concern in horses."( Aubrière, MC; Bouraima-Lelong, H; Caudron, I; Chavatte-Palmer, P; Couturier-Tarrade, A; Dahirel, M; Dubois, C; Gautier, C; Guenon, I; Lagofun, B; Lejeune, JP; Mendoza, L; Nouveau, E; Robles, M; Serteyn, D; Viguié, C; Wimel, L, 2018)
"Obesity is one of the main risk factors for T2DM and its management requires a multidisciplinary approach, which may include pharmacotherapy."( Aronne, LJ; Chukir, T; Saunders, KH; Shukla, AP, 2018)
"Obesity is the major pathophysiologic driver of T2DM; conversely 5-10% weight loss leads to significant improvement in glycemic control, lipids and blood pressure."( Aronne, LJ; Chukir, T; Saunders, KH; Shukla, AP, 2018)
"Maternal obesity is associated with large-for-gestational-age (LGA) neonates and programming of obesity-related cardiovascular disease in the offspring, however, the mechanisms that lead to the later are unclear."( Casanello, P; Krause, BJ; Muñoz-Muñoz, E; Uauy, R, 2018)
"Obesity is a chronic, multifactorial origin disease that has recently become one of the most frequent lifestyle disorders."( Antkiewicz-Michaluk, L; Romanska, I; Surowka, AD; Szczerbowska-Boruchowska, M; Wrobel, P; Ziomber, A, 2018)
"Obesity is a well-known risk factor of breast cancer in post-menopausal women that also correlates with a diminished therapeutic response."( Auxenfans, C; Billard, H; Boby, C; Bougaret, L; Caldefie-Chezet, F; Damour, O; De la Foye, A; Delort, L; Le Huede, C; Mojallal, A; Rossary, A; Vasson, MP, 2018)
"Obesity is a risk factor for kidney stones and a positive correlation of unknown etiology between increased body size, and elevated urinary oxalate excretion has been reported."( Alshaikh, A; Amin, R; Asplin, J; Bashir, M; Granja, I; Hassan, H; Jeon, S; Jung, D; Matern, D; Ratakonda, S; Sharma, S, 2018)
"Obesity is associated with osteoarthritis and the need for joint surgery."( Fleisher, LA; Gaulton, TG; Neuman, MD, 2018)
"Obesity is associated with an increased risk of developing dependence in the 2 years after joint surgery."( Fleisher, LA; Gaulton, TG; Neuman, MD, 2018)
"Obesity is associated with increased inflammation and insulin resistance."( Andersen, JR; Christensen, MHE; Fadnes, DJ; Mellgren, G; Midttun, Ø; Nygård, OK; Pedersen, ER; Røst, TH; Ueland, PM; Ulvik, A; Våge, V, 2018)
"The prevalence of obesity is on the increase in Ghana, and the intake of sugar-sweetened beverages may be a determinant."( Amoateng, AY; Doegah, PT, 2018)
"Obesity is highly correlated with the dysbiosis of intestinal microbiota, and bifidobacteria are one of the soft targets of this metabolic syndrome."( Hor, PK; Mondal, KC; Ojha, D; Ray, M; Singh, SN; Soren, JP, 2018)
"Obesity is a major risk factor for hepatocellular carcinoma (HCC) and is typically accompanied by higher levels of serum dipeptidyl peptidase 4 (DPP4)."( Bao, ZJ; Fu, GB; Huang, S; Huang, WJ; Qin, CJ; Tang, L; Wang, HY; Wang, MD; Wen, W; Yan, HX; Yang, Y; Zeng, M; Zhang, HL; Zhao, LH; Zhou, WP; Zhou, X, 2018)
"Obesity is a multifactor disorder with evidence supporting the role of the genetic factor in its etiology."( AbdElmoneim, A; Abdu Allah, AM; Al-Ahmadi, NS; Eldosouky, MK, 2018)
"Obesity is a major risk factor for type 2 diabetes and may complicate type 1 diabetes."( Brown, E; Cuthbertson, DJ; Wilding, JP, 2018)
"Obesity is one of the major causes for development of T2DM."( Ahuja, A; Chaudhuri, T; Goyal, G; Khanna, S; Majumdar, K; Seetharamaiah, S; Tantia, O, 2018)
"Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function."( Ahlqvist, E; Almgren, P; Calbet, JAL; de Pablos-Velasco, P; Edlund, A; Ekman, C; Ekström, O; Eliasson, L; Fernandez, C; Groop, L; Hansson, O; Hjort, L; Holmberg, HC; Jörgensen, SW; Martin-Rincon, M; Mattiasson, M; Morales-Alamo, D; Oskolkov, N; Ottosson, F; Pérez-López, A; Perez-Suarez, I; Stenkula, KG; Ström, K; Vaag, A; Wierup, N; Zhou, Y, 2018)
"Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well as with augmented hepatic de novo lipogenesis, which implies increased triose phosphate fluxes that may lead to increased methylglyoxal (MG) and its catabolic end product D-lactate."( Bains, Y; Caccavello, R; Garay-Sevilla, ME; Gugliucci, A; Luevano-Contreras, C; Rodríguez-Mortera, R; Solorio-Meza, S, 2018)
"Obesity is related to a dynamic extracellular matrix (ECM) remodeling, which involves the synthesis and degradation of different proteins, such as tenascin C (TNC) in the adipose tissue (AT)."( Becerril, S; Catalán, V; Frühbeck, G; Gómez-Ambrosi, J; Llorente, M; Méndez-Giménez, L; Ramírez, B; Rodríguez, A; Sáinz, N; Unamuno, X, 2018)
"Depression and obesity are common conditions with major public health implications that tend to co-occur within individuals."( Milaneschi, Y; Penninx, BW; Simmons, WK; van Rossum, EFC, 2019)
"Family history of obesity is the major predictor of obesity, and the metabolic abnormalities on amino acids, acylcarnitines, inflammation, insulin resistance, and NAFLD."( Caballero, AE; Duggirala, R; González-Chávez, A; Herrera-Rosas, A; Ibarra-González, I; León-Hernández, M; López-Alvarenga, JC; Mummidi, S; Romero-Ibarguengoitia, ME; Serratos-Canales, MF; Vadillo-Ortega, F, 2018)
"Maternal obesity is associated with prolonged and dysfunctional labour, potentially through decreased synthesis of prostaglandins that stimulate myometrial contractions."( Elmes, M; Gibson, RA; Khan, R; Liu, G; Muhlhausler, B; Muir, R; Quenby, S; Shmygol, A, 2018)
"Obesity is causally associated with atherosclerosis, and adipose tissue (AT)-derived exosomes may be implicated in the metabolic complications of obesity."( Du, H; Gu, X; Liu, X; Shao, X; Sun, C; Tian, J; Wang, H; Wang, X; Xie, Z; Yu, B, 2018)
"Obesity is associated with both endoplasmic reticulum (ER) stress and chronic metabolic inflammation."( Cai, J; Chen, T; Dai, J; Fang, J; Feng, Y; Liu, J; Liu, Y; Lv, S; Rui, L; Shan, B; Wang, Y; Wu, Y; Xia, Z; Xie, D; Zheng, L, 2018)
"Obesity is a metabolic disease with a serious health burden in children and adults, and it induces a variety of conditions including subfecundity."( Bian, C; Huang, S; Wan, X; Wu, D; Xiang, J; Zhang, Q, 2018)
"Obesity is an epidemic disease that is increasing worldwide and is a major risk factor for many metabolic diseases."( Guo, J; Liu, G; Su, Z; Ye, Z, 2018)
"Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome."( Ardévol, A; Blay, M; Casanova-Martí, À; Gil-Cardoso, K; Ginés, I; Pinent, M; Serrano, J; Terra, X, 2018)
"Obesity is associated with hypoxic adipose tissues, including those in the breast, resulting in increased production of some of the aforementioned factors."( Ancukiewicz, M; Babykutty, S; Boucher, Y; Chin, SM; Duda, DG; Fukumura, D; Gomes-Santos, IL; Hoffmman, U; Huang, Y; Incio, J; Jain, RK; Jung, K; Kawaguchi, K; Krop, IE; Ligibel, JA; McManus, DT; Pinter, M; Puchner, SB; Rahbari, NN; Roberge, S; Schlett, CL; Suboj, P; Tolaney, SM; Vardam, TD; Wang, D, 2018)
"Obesity is a public concern and is responsible for various metabolic diseases."( Jung, S; Kim, E; Kim, Y; Lim, SM; Seok, PR; Shin, JH; Yoo, SH, 2018)
"Obesity is associated with increased brain responses to food stimuli at the level of the reward system."( Coppin, G; Golay, A; Pataky, Z; Sander, D, 2018)
"Human obesity is characterized by an increased capacity to produce and release 5-HT from the proximal small intestine, which is strongly linked to higher body mass, and glycemic control."( Cvijanovic, N; Due, SL; Fontgalland, D; Hollington, P; Isaacs, NJ; Jackson, VM; Keating, DJ; Liou, AP; Lumsden, AL; Martin, AM; Nguyen, NQ; Pezos, N; Rabbitt, P; Rayner, CK; Schober, G; Sposato, L; Sun, EWL; Thazhath, SS; Wattchow, DA; Wu, T; Young, RL, 2018)
"Obesity is linked to dyslipidemia, proinflammatory state, and hyperleptinemia."( Adams-Huet, B; Franklin, B; Mitchell, J; Phillips, M; Shah, M, 2018)
"Conversely, obesity is confirmed to be an independent risk factor for carotid plaque destabilization, particularly in males aged < 70 years, significantly increasing such risk among patients with metabolic syndrome."( Anemona, L; Bonanno, E; Cardellini, M; Di Daniele, N; Federici, M; Ippoliti, A; Legramante, IM; Mauriello, A; Montanaro, M; Rovella, V; Saggini, A; Santeusanio, G; Scimeca, M, 2018)
"Obesity is a serious and increasing health problem worldwide, and the inhibition of adipogenesis is considered to be a potential therapeutic target for it."( Ahn, KS; Jung, SH; Ko, JH; Nam, D; Um, JY, 2018)
"Obesity is an increasing epidemic worldwide and novel treatments are urgently needed."( Afonso, C; Almeida, T; Azevedo, C; Correia-da-Silva, M; Freitas, S; Moreira, J; Palmeira, A; Pinto, M; Sousa, E; Urbatzka, R; Vasconcelos, V, 2018)
"In addition, obesity is accompanied by increased signaling through the leptin receptor, which can promote activation of both the sympathetic nervous system and the renin-angiotensin system and can directly stimulate the secretion of aldosterone."( Packer, M, 2018)
"The rates of obesity are increasing worldwide and this condition is now recognized as a leading preventable cause of cancer."( Argolo, DF; Hudis, CA; Iyengar, NM, 2018)
"Obesity is an established risk factor for periprosthetic joint infections after total knee arthroplasty (TKA)."( Chin, SJ; Clarke, HD; Moore, GA; Spangehl, MJ; Young, SW; Zhang, M, 2018)
"Obesity is a major cause of insulin resistance and contributes to the development of T2DM."( Gao, J; Li, Y; Liang, B; Liao, S; Liu, P; Wang, J; Xu, S; Yang, W; Zhang, L; Zhang, Z; Zhou, H, 2018)
"Obesity is a global public health problem."( Guo, F; Sun, X; Wang, M; Xu, L; Yang, D; Zhang, D, 2018)
"Obesity is a global health problem with an up-regulated inflammatory reaction."( Kuo, YF; Shih, JM; Shih, YM; Yeh, CL; Yeh, SL, 2018)
"Maternal obesity is associated with adverse outcomes."( Gázquez, A; Gill, C; Koletzko, B; Larqué, E; Patel, N; Poston, L; Ruíz-Palacios, M; Uhl, O, 2018)
"Obesity is a public health problem, associated with salt sensitive hypertension, kidney inflammation, and fibrosis."( Carretero, OA; Kumar, N; Liao, TD; Maheshwari, M; Monu, SR; Peterson, EL; Romero, CA, 2018)
"Obesity is a complex and multifaceted condition."( Bedeltavana, A; Bellissimo, N; Brett, NR; Famouri, M; Fararouie, M; Mazloom, Z; Mazloomi, SM; Mohammadi-Sartang, M; Totosy de Zepetnek, JO, 2018)
"Obesity is characterized by a chronic inflammatory process, with an increased volume of total adipose tissue, especially visceral, which secretes pro-inflammatory cytokines such as TNF-α and IL-6."( Andrews, M; Arredondo-Olguín, M; Briones, L; Pizarro, F, 2018)
"Obesity is a worldwide epidemic affecting millions of people."( Madiehe, AM; Meyer, M; Onani, MO; Sibuyi, NRS; Thovhogi, N, 2018)
"Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation."( Filarski, R; Karczewska-Kupczewska, M; Majewski, R; Matulewicz, N; Nikołajuk, A; Stefanowicz, M; Strączkowski, M, 2018)
"We hypothesize that obesity is also associated with neural plasticity in these circuits, and this may underlie persistent changes in behavior, energy balance, and body weight."( Kravitz, AV; Matikainen-Ankney, BA, 2018)
"Hypertension and obesity are usually associated with systemic and tissular inflammation."( Diez, ER; Ferder, L; Manucha, W; Prado, NJ, 2018)
"Male obesity is associated with decreased testosterone levels but the pathophysiological mechanisms behind this association are not completely understood."( Belo, S; Bettencourt-Silva, R; Carvalho, D; Costa, MM; Freitas, P; Magalhães, D; Neves, JS; Oliveira, SC; Pedro, J; Queirós, J; Souteiro, P; Varela, A, 2018)
"Obesity is a serious and growing world healthy problem affecting developed and developing countries."( de Oliveira, FLP; Figueiredo, VP; Gomes, JAE; Leite, ALJ; Lopes, LR; Nicolato, RLC; Ribeiro, SMLT; Talvani, A, 2018)
"Obesity is a result of positive energy balance."( Adamska-Patruno, E; Golonko, A; Gorska, M; Goscik, J; Kretowski, A; Ostrowska, L; Pietraszewska, B, 2018)
"Obesity is a complex disease associated with environmental and genetic factors."( Assadi-Porter, FM; Carnicelli, V; Chiellini, G; Ghelardoni, S; Lorenzini, L; Reiland, H; Rogowski, M; Saba, A; Sabatini, M; Selen Alpergin, ES; Tonelli, M; Zucchi, R, 2018)
"Obesity is a crucial public health problem worldwide and is considered as the main cause of many chronic diseases."( Abolfazl, B; Alireza, O; Laleh, P; Mohammad, AJ; Nazila, F; Shahriar, A; Yaser, K, 2018)
"Obesity is strongly associated with leptin resistance."( Adan, RAH; Beerens, S; de Git, KCG; la Fleur, SE; Luijendijk, MCM; Peterse, C; van der Plasse, G, 2018)
"Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations."( Campos, RMDS; Carvalho-Ferreira, JP; Clemente, APG; Corgosinho, FC; Dâmaso, AR; Masquio, DCL; Mello, MT; Molin Netto, BD; Tock, L; Tufik, S, 2018)
"Obesity is a heterogeneous phenotype and risk associations to non-communicable diseases such as cardiovascular disease and type 2 diabetes are influenced by several factors."( Chambers, S; Jansen, E; Nikolova, V; Papacleovoulou, G; Pataia, V; Poston, L; Samuelsson, AM; Taylor, PD; Williamson, C, 2019)
"Maternal obesity is associated with low birth weight (LBW) of piglets."( Deng, Z; Jiang, S; Li, S; Lu, J; Peng, J; Song, T; Wei, H; Xu, T; Yang, Y, 2018)
"Obesity is believed to negatively affect male semen quality and is accompanied by dysregulation of free fatty acid (FFA) metabolism in plasma."( Ge, X; Hu, X; Jing, J; Liang, W; Shao, Y; Wang, C; Yao, B; Zeng, R, 2018)
"Obesity is a worldwide public health concern yet no safe therapies are currently available."( Domingos, AI; Pirzgalska, RM, 2018)
"Obesity is a global disease that causes many metabolic disorders."( Deng, X; Fu, C; Guo, J; Huang, L; Jiang, Y; Pan, H; Su, Z, 2018)
"Obesity is a low-grade sustained inflammatory state that causes oxidative stress in different metabolic tissues, which leads to insulin resistance and nonalcoholic fatty liver disease (NAFLD)."( Nagata, N; Ota, T; Xu, L, 2018)
"Obesity is associated with periodontitis, but the mechanisms underlying this association have yet to be unraveled."( Damanaki, A; Deschner, J; Gao, J; Götz, W; Hiththetiya, K; Jäger, A; Memmert, S; Nguyen, KA; Nokhbehsaim, M; Wahl, G, 2019)
"Managing obesity is of interest to address the worldwide health problem; however, the role of genetic variability in human obesity development and specific targets for obesity-related metabolic disease have not been thoroughly studied."( Cho, S; Park, KW; Yang, J, 2018)
"Overweight and obesity are multifactorial diseases caused by an imbalance in energy metabolism."( Frey, D; Ghielmetti, V; Liesegang, A; Rüegg, S; Wichert, B, 2018)
"While overweight/obesity are major determinants of GDM, independent effects on critical birth outcomes remain unclear."( Dudenhausen, JW; Eilers, E; Henrich, W; Loui, A; Melchior, K; Ott, R; Plagemann, A; Rancourt, RC; Schellong, K; Stupin, JH; Ziska, T, 2018)
"Overweight and obesity are important risk factors for diabetes, cardiovascular diseases, and premature death in modern society."( Abbate, F; Germanà, A; Guerrera, MC; Laura, R; Levanti, M; Mania, M; Montalbano, G; Navarra, M; Vega, JA, 2018)
"Obesity is a prominent risk factor for type 2 diabetes."( Singh, H; Venkatesan, V, 2018)
"Obesity is an independent risk factor for severe acute pancreatitis (AP)."( Huang, Z; Tang, C; Wang, M; Wang, R; Ye, C, 2018)
"Hypertension in obesity is associated with increased insulin resistance, vascular mass and body mass index (BMI)."( Gradin, K; Persson, B, 2018)
"Obesity is accompanied by changes in expression of adipose factors that act on local tissues and systemically."( Crean-Tate, KK; Reizes, O, 2018)
"Although obesity is increasing worldwide, experimental studies examining the possible association between obesity and susceptibility to chemical toxicity are limited."( Akagi, JI; Cho, YM; Imaida, K; Matsushita, K; Mizuta, Y; Nishikawa, A; Ogawa, K; Toyoda, T, 2018)
"In line of this, obesity is associated with telomere shortening."( De Oliveira, BAP; Marchini, JS; Nicoletti, CF; Nonino, CB; Noronha, NY; Pinhanelli, VC; Pinhel, MS; Quinhoneiro, DCG, 2018)
"obesity is related to shorter telomeres."( De Oliveira, BAP; Marchini, JS; Nicoletti, CF; Nonino, CB; Noronha, NY; Pinhanelli, VC; Pinhel, MS; Quinhoneiro, DCG, 2018)
"Obesity is a global health problem and treatment options are still insufficient."( Banks, WA; Huber, G; Hübner, N; Raasch, W; Saar, K; Schuster, F; Stölting, I; Wing, EE, 2018)
"Obesity is partly driven by unhealthy food choices underpinned by cognitive biases, including approach bias (a tendency to move towards food cues) and delay discounting (a preference for immediate rewards)."( Castine, B; de Courten, B; Hawker, C; Kakoschke, N; Verdejo-Garcia, A, 2018)
"Obesity is linked to worse asthma symptoms."( Alexandre, EC; André, DM; Antunes, E; Calixto, MC; Horimoto, CM, 2018)
"Obesity is associated with impaired NP/GC-A/cGMP signaling, which possibly contributes to the development of type 2 diabetes and its cardiometabolic complications."( Baba, HA; Birkenfeld, AL; Doose, S; Krebes, L; Kuhn, M; Nakagawa, H; Potapenko, T; Tauscher, S; Völker, K; Werner, F, 2018)
"Obesity is a complex disorder, the development of which is modulated by a multitude of environmental, behavioral and genetic factors."( Hasnain, S; Shahid, SU, 2018)
"Obesity is a medical condition with increasing prevalence, characterized by an accumulation of excess fat that could be improved using some bioactive compounds."( Aranaz, P; Calavia, D; Eder-Azanza, L; González-Navarro, CJ; Hurtado, C; López-Yoldi, M; Martínez, JA; Navarro-Herrera, D; Romo-Hualde, A; Vizmanos, JL; Zabala, M, 2018)
"Obesity is the most common metabolic disease in developed countries and has become a global epidemic in recent years."( Choi, KC; Jeong, JH; Jun, W; Kang, HB; Kim, H; Kim, JH; Kim, Y; Kwak, S; Lee, J; Park, SH; Song, JH; Sung, GJ, 2018)
"Obesity is an independent risk factor for the development of heart failure, and the two commonly co-exist."( Logue, J; McDowell, K; Petrie, MC; Raihan, NA, 2018)
"The prevalence of obesity is increasing rapidly worldwide, and dietary intake is strongly associated with obesity-related chronic diseases."( Feng, R; Ju, L; Sun, C; Sun, G; Sun, Q; Wang, C; Zhang, Y, 2019)
"Obesity is a risk factor for infertility, but mechanisms underlying this risk are unclear."( Bertsch, AD; Dao, N; Gray, NW; Grzybowski, CW; Lenkey, JA; Levi, NJ; Moseman, AW; Redweik, GAJ; Walsh, HE; Wilson, CW, 2018)
"Because obesity is associated with many co-morbidities, including diabetes mellitus, this study evaluated the second-meal effect of a commercial prebiotic, inulin-type fructans, and the effects of the prebiotic on faecal microbiota, metabolites and bile acids (BA)."( Alexander, C; Cross, TL; de Godoy, MRC; Devendran, S; Neumer, F; Ridlon, JM; Suchodolski, JS; Swanson, KS; Theis, S, 2018)
"Obesity is a risk factor for co-morbidities such as diabetes, hypertension, osteoarthritis and cardiovascular diseases."( Abdul Aziz, NS; Ambak, R; Aris, T; Jamil, AT; Mohamad Nor, NS; Shahar, S, 2018)
"Obesity is an emerging global public health concern as it is related to chronic diseases and its impact to health related quality of life."( Ahmad, NA; Ambak, R; Aris, T; Mohamad Nor, NS; Mohd Tamil, A; Omar, MA; Puteh, N; Shahar, S, 2018)
"Obesity is related to the increased incidence of hypertension and in healthy individuals, blood pressure changes with age and body mass."( Ambak, R; Aris, T; Fazliana, M; Liyana, AZ; Mohamad Nor, NS; Omar, A; Salleh, NA; Shamsudin, UK, 2018)
"Obesity is a global health burden in the non-communicable diseases and much efforts have been implemented in the past decade in response to the rise of obesity prevalence among the Malaysian population."( Abd Razak, MA; Abdul Aziz, NS; Ahmad, MH; Ambak, R; Aris, T; Baharuddin, A; Cheong, SM; Ishak, IH; Megat Radzi, MR; Mohamad Nor, NS; Mohd Zaki, N; Wan Kozil, WNK; Yusof, M, 2018)
"Overweight and obesity are major health concerns worldwide, and are major predisposing factors for type 2 diabetes."( Audet, D; Demitri, C; Heshmati, HM; Panteca, E; Ron, ES; Sannino, A; Surano, I; Urban, LE; Zohar, Y, 2018)
"Obesity is a serious health risk factor strongly associated with insulin resistance and type 2 diabetes; however, the underlying mechanisms associating obesity with insulin resistance remain unknown."( Eom, J; Heredia, J; Kang, SW; Kim, D; Kim, J; Kwon, M; Song, Y, 2018)
"Obesity is a major factor in the development of nonalcoholic fatty liver disease (NAFLD) and its progression to steatohepatitis."( Kumar, RB; Mathews, SE; Shukla, AP, 2018)
"Obesity is the most common nutritional disorder in dogs."( Cortese, L; Giovazzino, A; Guccione, J; Palatucci, AT; Pernice, V; Piantedosi, D; Rubino, V; Ruggiero, G; Terrazzano, G, 2018)
"Obesity is a risk factor for hypertension, diabetes mellitus (DM), dyslipidemia, and hyperuricemia."( Hisatome, I; Jalal, DI; Johnson, RJ; Kuwabara, M; Kuwabara, R; Lanaspa, MA; MacLean, PS; Niwa, K; Ohno, M; Roncal-Jimenez, CA; Smits, G; Yracheta, JM, 2018)
"Obesity is a complex disease characterized by the accumulation of excess body fat, which is caused by an increase in adipose cell size and number."( Ferroni, L; Giorgi, C; Lebiedzinska-Arciszewska, M; Missiroli, S; Morganti, C; Morganti, L; Occhionorelli, S; Perrone, M; Ramaccini, D; Wieckowski, MR; Zavan, B, 2019)
"Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders."( Aarts, SABM; Beckers, L; de Winther, MPJ; den Toom, M; Gerdes, N; Gijbels, MJJ; Lutgens, E; Reiche, ME, 2018)
"Abdominal obesity is the single-most important risk factor for MetS and its predisposition to T2DM."( Abhishek, V; Anoop, S; Misra, A; Mohan, V; Pradeepa, R; Soares, MJ; Vaidya, R, 2018)
"Obesity is present in up to 45% of patients with heart failure (HF)."( Ambrosy, AP; Borlaug, BA; Cooper, LB; DeVore, AD; Groake, JD; Hernandez, AF; Lala, A; Margulies, KB; McNulty, SE; Mentz, RJ; Michael Felker, G; Sharma, A; Vader, J; Velazquez, EJ, 2018)
"Obesity is a major public health issue, and new pharmaceuticals for weight management are needed."( Birkenfeld, AL; Carson, CG; Jepsen, CH; Kabisch, M; McGowan, B; Mosenzon, O; O'Neil, PM; Pedersen, SD; Wharton, S; Wilding, JPH, 2018)
"The concepts that obesity is merely a consequence of overeating, and that metabolic health then reflects obesity, may be insufficient and potentially flawed."( Borrows, R; Chan, W; Smith, B; Stegall, M, 2019)
"Obesity is associated with increased blood concentrations of the anorexigenic hormone leptin; however, obese individuals are resistant to its anorexigenic effects."( Alsaigh, T; Friedmann-Morvinski, D; Huang, C; Kistler, EB; Kleifeld, O; Li, JB; Mazor, R; Rousso-Noori, L; Schmid-Schönbein, GW; Verma, IM, 2018)
"Obesity is a predisposing factor for obstructive sleep apnoea (OSA)."( Agarwal, R; Chaudhry, D; Dhooria, S; Sehgal, IS; Virdi, S, 2016)
"The obesity is rapidly increasing health problem."( Al Habashi, WY; Hassaein, AS; Wahdan, M, 2016)
"Obesity is characterized by endothelial dysfunction associated with a condition of vascular low-grade inflammation."( Bernardini, N; Blandizzi, C; Colucci, R; Masi, S; Taddei, S; Virdis, A, 2019)
"Obesity is an important nutritional disorder worldwide."( Borges, MS; Bortolin, RC; Chaves, PR; da Boit Martinello, K; da Rosa-Siva, HT; da Silva, FR; da Silva, J; Gasparotto, J; Gelain, DP; Moreira, JCF; Nordin, AP; Rabelo, TK; Silva, LFO; Soares, K, 2018)
"When obesity is caused by consumption of a high-fat diet, the tumor suppressor pRb is phosphoinactivated in the neurons of the mediobasal hypothalamus, a brain area critical for energy-balance regulation."( Chua, S; Iqbal, NJ; Liu, SM; Lu, Z; Schwartz, GJ; Zhu, L, 2018)
"Basic research on obesity is becoming more important due to an increasing number of obese people."( Aoyama, M; Maejima, Y; O'Hashi, R; Shimomura, K; Yokota, S, 2019)
"Obesity is an independent risk factor for cardiovascular disease."( Bursill, C; Duong, M; Nankivell, V; Nicholls, SJ; Uno, K, 2018)
"Obesity is related to many major diseases and cancers."( Khan, S; Munir, I; Nyasani, E; Payne, K; Perez, M, 2019)
"Obesity is associated with local and systemic complications in acute pancreatitis."( Finamor, I; García, R; Martí-Andrés, P; Monsalve, M; Pérez, S; Prieto, I; Rius-Pérez, S; Sastre, J, 2019)
"Obesity is one of the major public health issues, and its prevalence is steadily increasing all the world over."( Brissard, L; Degrace, P; Demizieux, L; Hichami, A; Khan, NA; Leemput, J; Maquart, G; Passilly-Degrace, P, 2018)
"Obesity is a major current public health problem worldwide due to the severe co-morbid conditions that this disease entails."( Bravo-Sagua, R; Breitwieser, G; Cifuentes, M; Fuentes, C; Lavandero, S; Mattar, P; Tobar, N; Troncoso, R, 2018)
"Obesity is associated with inflammation, dysregulated adipokine secretion, and disrupted adipose tissue mitochondrial function."( Bauzá-Thorbrügge, M; Galmés-Pascual, BM; Gianotti, M; Lladó, I; Proenza, AM; Rodríguez-Cuenca, S; Sbert-Roig, M; Vidal-Puig, A, 2019)
"Obesity is a major risk factor for the development of chronic heart failure (CHF) and does not only pose diagnostic challenges, but also has prognostic implications for these patients."( Antonopoulos, AS; Katsi, V; Marketou, M; Parthenakis, F; Tousoulis, D; Vrachatis, D, 2019)
"Obesity is a proven risk factor for neurodegenerative disease like Alzheimer's disease (AD)."( Abo-ELmatty, DM; Ali, AA; Mesbah, NM; Mohamed, HE; Sakr, AT; Saleh, SM, 2018)
"Obesity is one of the largest global health problems associated with increased morbidity and mortality mediated by its association with several other metabolic disorders."( Gupta, V; Sachdeva, MP; Saini, S; Walia, GK, 2018)
"Obesity is a clinically relevant and highly prevalent somatic comorbidity of major depression (MDD)."( Arolt, V; Baune, BT; Böhnlein, J; Bürger, C; Dannlowski, U; Dohm, K; Emden, D; Enneking, V; Förster, K; Goltermann, J; Grotegerd, D; Hahn, T; Heindel, W; Kaehler, C; Krughöfer, R; Kugel, H; Leehr, EJ; Leenings, R; Meinert, S; Opel, N; Redlich, R; Repple, J; Steinmann, LM; Thalamuthu, A; Winter, N; Zaremba, D, 2019)
"Obesity is a prevalent multifactorial chronic disorder characterized by metabolic dysregulation."( Alves, LB; Barbé-Tuana, FM; Bortolin, R; de Bastiani, MA; Grun, LK; Guma, FCR; Jones, MH; Klamt, F; Lavandoski, P; Mengden, LV; Moreira, JCF; Mottin, CC; Padoin, AV; Parisi, MM; Pierdoná, V; Teixeira, NDR, 2018)
"Obesity is associated with endocannabinoid system (ECS) over activation and oxidative stress."( Andrade, CBV; De Almeida, MM; de Brito Fassarella, L; De Souza, LL; Fortunato, RS; Miranda, RA; Pazos-Moura, CC; Rocha, CPDD; Souza, AFP; Trevenzoli, IH, 2018)
"Obesity is an effect regulator, which can predict an association between increased serum leptin level and the incidence of MetS in lean subjects."( Choi, JR; Huh, JH; Kim, JY; Kim, SH; Koh, SB, 2018)
"Obesity is a major public health problem worldwide."( Ford, SP; Guo, W; Maimaiti, R; Nathanielsz, PW; Ren, J; Sun, M; Wang, Q; Zhu, C, 2019)
"Obesity is a metabolic disorder that predisposes to numerous diseases and has become a major global public health concern."( Bazzano, MV; Berón de Astrada, M; Elia, EM; Martinez, N; Sarrible, GB, 2018)
"Obesity is a severe public health problem worldwide."( Liu, L; Liu, Y; Ma, Y; Wang, N; Wen, D, 2018)
"Obesity is associated with many complications, including type 2 diabetes and painful neuropathy."( Bonomo, R; Bookout, AL; Gautron, L; Gavini, CK; Lee, S; Mansuy-Aubert, V, 2018)
"Severe obesity is difficult to treat, and non-surgical treatment is not supported by robust evidence."( Bosco, G; Calugi, S; Dalle Grave, R; El Ghoch, M; Valenti, C; Valerio, L; Zini, D, 2020)
"Obesity is associated with the changes in gut microbiota."( Dou, H; Guo, L; Huang, W; Li, D; Wu, H, 2018)
"Obesity is associated with progression of chronic kidney disease (CKD)."( Appel, GB; Block, GA; Chertow, GM; Chin, MP; Coyne, DW; Goldsberry, A; Kalantar-Zadeh, K; Meyer, CJ; Molitch, ME; Pergola, PE; Raskin, P; Rossing, P; Silva, AL; Spinowitz, B; Sprague, SM, 2018)
"Obesity is a significant risk factor for low back pain (LBP) and IVD degeneration."( Fairbank, JCT; Segar, AH; Urban, J, 2019)
"Obesity is associated with altered microbial load in metabolic tissues that can contribute to metabolic inflammation."( Arha, D; Maurya, CK; Rai, AK; Schertzer, JD; Sharma, A; Singh, S; Tamrakar, AK; Varshney, S, 2019)
"Obesity is an escalating global epidemic caused by an imbalance between energy intake and expenditure."( Mao, L; Wang, Y; Xu, P; Zhou, J, 2018)
"Obesity is a growing global health problem."( Halenova, T; Kyzyma, O; Ostapchenko, L; Prylutskyy, Y; Raksha, N; Ritter, U; Savchuk, O; Scharff, P; Vovk, T, 2018)
"Obesity is a critical risk factor for various diseases including type II diabetes, cerebral infarction, cardiovascular diseases, and various cancers."( Lee, HW; Pyo, S, 2019)
"Diet-induced obesity is strongly associated with nonalcoholic fatty-liver disease (NAFLD) and insulin resistance."( Chen, JW; Ho, CT; Kong, ZL; Lai, CS; Pan, MH; Wu, JC, 2018)
"Obesity is the result of white adipose tissue accumulation where excess of food energy is stored to form triglycerides."( Cacciatore, I; D'Orazi, G; Di Gregorio, J; Flati, V; Marchisio, M; Marino, A; Pierdomenico, L; Robuffo, I; Spalletta, S; Toniato, E, 2018)
"Obesity is reaching pandemic proportions and is a major risk factor for certain malignancies, but the impact of obesity on immune responses, in general and in cancer immunotherapy, is poorly understood."( Aguilar, EG; Aljumaily, R; Blazar, BR; Canter, RJ; Dunai, C; Griffith, TS; Grossenbacher, SK; Hartigan-O'Connor, DJ; Ibrahimi, S; Isseroff, RR; Kelly, K; Khuat, LT; Le, CT; Longo, DL; Luna, JI; Machiorlatti, M; Maverakis, E; Méndez-Lagares, G; Merleev, A; Minnar, CM; Mirsoian, A; Monjazeb, AM; Mukherjee, S; Murphy, WJ; Rebhun, RB; Saha, A; Schalper, KA; Stoffel, KM; Sturgill, IR; Tarantal, AF; Vesely, SK; Wang, Z; Withers, SS, 2019)
"Obesity is frequently associated with metabolic disease."( Castaño, C; Kalko, S; Novials, A; Párrizas, M, 2018)
"Obesity is characterized by accumulation of adipose tissue and is one the most important risk factors in the development of insulin resistance."( Braud, L; Czibik, G; Derumeaux, G; Foresti, R; Kitagishi, H; Manin, S; Motterlini, R; Muchova, L; Pini, M; Sawaki, D; Ternacle, J, 2018)
"Obesity is associated with increased cardiovascular morbidity and mortality, but the direct signals to initiate or exaggerate cardiomyopathy remain largely unknown."( Ding, L; Jiang, S; Jin, P; Weng, J; Xu, Y; Zhu, X, 2019)
"Obesity is one of the main risk factors for type 2 diabetes (T2D), representing a major worldwide health crisis."( Apovian, CM; O'Neil, PM; Okemah, J, 2019)
"Obesity is becoming one of the leading risk factors of coronary heart disease, hypertension, cerebrovascular disease."( Ashcheulova, T; Gerasimchuk, N; Honchar, O; Kovalyova, O, 2018)
"Obesity is a continually growing pandemic leading to many diseases that affect the overall quality of life."( Abdallah, DM; Abdel-Mottaleb, Y; Attia, RT; El-Abhar, HS; El-Maraghy, NN, 2019)
"Background Obesity is a chronic inflammatory disorder in which leptin, adiponectin and C-reactive protein (CRP) play an important role."( Bizerea, T; Doroș, G; Gafencu, M; Mărginean, O; Stroescu, RF; Voicu, A, 2019)
"Since obesity is largely responsible for the growing incidence of renal tubulointerstitial inflammation, exploration into the mechanisms of obesity‑associated tubulointerstitial inflammation is essential."( Golos, M; He, J; Shao, X; Shi, B; Sun, H, 2019)
"Obesity is associated with oxidative stress, a major factor in carcinogenesis, and with high leptin concentration."( der Vartanian, A; Mahbouli, S; Ortega, S; Rossary, A; Rougé, S; Talvas, J; Vasson, MP, 2018)
"Obesity is associated with disrupted satiety regulation."( Beyak, MJ; Park, SJ; Yu, Y, 2019)
"Obesity is one of the most important risk factors for chronic metabolic disorders."( Goto, T, 2019)
"Obesity is a crucial factor in the development of metabolic abnormalities, including glucose intolerance, insulin resistance, metabolic syndrome, low-grade inflammation and oxidative stress."( Hernández Bautista, RJ; Königsberg, M; López Díaz Guerrero, NE; Mahmoud, AM, 2019)
"Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer."( Ghaben, AL; Scherer, PE, 2019)
"Obesity is associated with increased senescent cell burden and neuropsychiatric disorders, including anxiety and depression."( Burns, TC; Enikolopov, G; Fielder, E; Giorgadze, N; Ikeno, Y; Inman, C; Johnson, KO; Jurk, D; Kirkland, JL; Krüger, P; Langhi, LGP; Ogrodnik, M; Palmer, AK; Passos, JF; Pirtskhalava, T; Podgorni, O; Ruswhandi, RA; Schafer, M; Tchkonia, T; Victorelli, S; von Zglinicki, T; Weigl, M; Xu, M; Zhu, Y, 2019)
"Obesity is a growing health problem that has numerous comorbidities, including cardiovascular disease (CVD)."( Andrew, CA; Aronne, LJ; Saunders, KH; Shukla, AP, 2019)
"The prevalence of obesity is continuously increasing worldwide."( Gao, P; Yan, Z; Zhu, Z, 2019)
"Obesity is underpinned by both genetic and environmental factors, including a high-saturated-fat diet."( Huang, XF; Li, X; Qin, Y; Tang, R; Wang, H; Wang, Q; Weston-Green, K; Yu, Y; Zhang, P; Zheng, K; Zhou, Y, 2019)
"Obesity is often associated with a diminished response to insulin, leading to impaired suppression of HGP in obese mice."( Balland, E; Chen, W; Conductier, G; Coppari, R; Cowley, MA; Dodd, GT; Tiganis, T, 2019)
"Obesity is strongly correlated with lipotoxic cardiomyopathy, heart failure and thus mortality."( Adams, PD; Birse, RT; Bodmer, R; Dall'Agnese, A; Diop, SB; Guida, MC; Mai, A; Puri, PL; Toto, PC, 2019)
"Overweight and obesity are a global concern."( Chen, CM; Hsiao, TJ; Li, SC; Liu, CW; Shih, CK, 2019)
"Obesity is a risk factor for breast cancer (BC)."( López, A; Morales-Avila, E; Peña-Cano, MI; Saucedo, R; Valencia, J; Zavala-Moha, JA, 2019)
"Obesity is a serious health challenge in the world, and searching effective drugs to cure obesity is of great importance."( Chen, JJ; Chen, JL; Chen, QY; Jin, P; Li, AN; Li, QQ; Liao, ZM; Wang, KS; Yang, ZC; Zeng, GY, 2019)
"Abdominal obesity is significantly associated with increased trend even among the villagers."( Nanditha, A; Raghavan, A; Ramachandran, A; Satheesh, K; Simon, M; Snehalatha, C; Susairaj, P; Vijaya, L; Vinitha, R, 2019)
"Obesity is a highly prevalent and modifiable breast cancer risk factor."( Bonin, K; Camarillo, IG; Cook, KL; Hodges, K; Holmes, J; Jenks, MZ; Lelièvre, SA; Lo, HW; Muhlemann, JK; Rashid, H; Seewaldt, V; Shaikh, A; Sistrunk, C; Tenvooren, I; Vidi, PA; Wang, K, 2019)
"Obesity is one of the main challenges of public health in the 21st century."( Bai, Y; Cheng, Z; He, H; Ma, X; Wu, Y, 2019)
"Obesity is a worldwide public health concern requiring safe and effective strategies."( Choi, CW; Choi, EJ; Choi, SW; Do, SH; Kim, HJ; Kim, HS; Kim, SL; Seo, WD, 2019)
"Obesity is associated with the hypertrophy and hyperplasia of adipose tissue, affecting the healthy secretion profile of pro- and anti-inflammatory adipokines."( Casanova, E; Crescenti, A; Gibert-Ramos, A; Salvadó, J, 2019)
"Type 2 diabetes and obesity are associated with chronic hypoxia, which contributes to adipose tissue dysfunction and development of insulin resistance and metabolic disorders."( Abdollahifar, MA; Bahadoran, Z; Ghanbari, M; Ghasemi, A; Norouzirad, R; Rasouli, N, 2019)
"Obesity is associated with development of insulin resistance in adipose tissue (AT)."( Flores-Opazo, M; Naim, T; Stapleton, D; Trieu, J; Valladares-Ide, D; Zbinden-Foncea, H, 2020)
"Obesity is a chronic and multifactorial disease characterized by increased adipose tissue."( Benevides, ROA; Fontelles, JLL; França, LM; Gaspar, RS; Paes, AMA; Silva, SN; Teófilo, TS; Vale, CC, 2019)
"Obesity is a complex chronic disease of high prevalence worldwide."( Fu, J; Li, Y; Lu, P; Ma, X; Meng, M; Qiu, J; Sun, Y; Wang, D; Wang, J; Xu, L; Yan, Y; Yu, J; Yue, L; Zhang, Q; Zhao, W; Zheng, Y, 2019)
"Obesity is one of the most common and major health concerns worldwide."( Dou, H; Li, D; Wu, H, 2019)
"Obesity is one of the most serious public health problems."( Cao, X; Chen, X; Cheng, H; Ding, Z; Kong, Q; Li, C; Li, Y; Liu, L; Qi, T; Zhang, X, 2019)
"Obesity is a nutritional disorder resulting from a chronic imbalance between energy intake and expenditure."( Bazer, FW; Chen, S; Deng, J; Ren, W; Tan, B; Wu, G; Xia, Y; Yin, Y; Zhou, B; Zhu, G, 2019)
"Obesity is one of the most common comorbid conditions that is relevant both for a patient's overall health and the clinical outcomes of antipsoriatic therapies."( Chiricozzi, A; Girolomoni, G; Gisondi, P, 2019)
"Obesity is considered a clinic condition characterized by a state of chronic low-grade inflammation."( Bonmassar, E; Fuggetta, MP; Ravagnan, G; Villivà, C; Zonfrillo, M, 2019)
"Age-related obesity is characterized by leptin resistance and associated with heightened risk of metabolic disorders."( Baur, JA; Chellappa, K; Naidoo, N; Perron, IJ, 2019)
"On the other hand, obesity is a risk factor for several types of cancer and type 2 diabetes mellitus."( Alarcón, S; Niechi, I; Quezada, C; Sobrevia, L; Toledo, F, 2019)
"In addition, obesity is associated with many chronic diseases."( Han, Y; He, L; Liu, D; Tian, X; Wang, S; Yan, C, 2019)
"Obesity is characterized by hypertrophied adipocytes with a dysregulated adipokine secretion profile, increased recruitment of inflammatory cells, and impaired metabolic homeostasis that eventually results in the development of systemic insulin resistance, a phenotype of type 2 diabetes."( Atawia, RT; Bunch, KL; Caldwell, RB; Caldwell, RW; Toque, HA, 2019)
"Obesity is a major risk factor for diabetes, and these two metabolic conditions cause significant healthcare burden worldwide."( Chin, KY; Pang, KL, 2019)
"Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause."( Au, CC; Benito-Martin, A; Bhardwaj, P; Brown, KA; Ladumor, H; Moges, R; Oshchepkova, S, 2019)
"Obesity is becoming a global epidemic and is a risk factor for breast cancer."( Cao, L; Foglesong, GD; Huang, W; Queen, NJ; Widstrom, KJ, 2019)
"Obesity is a complex health disorder and a trigger to many diseases like Diabetes mellitus (DM) and breast cancer (BrCa), both leading causes of morbidity and mortality worldwide."( Alves, MG; Duarte, F; Faria, I; Fernandes, R; Jarak, I; Luis, C; Oliveira, PF; Soares, R, 2019)
"Obesity is intimately related to a chronic inflammatory state, with augmentation of macrophage infiltration and pro-inflammatory cytokine secretion in white adipose tissue (WAT) and mitochondrial dysfunction in skeletal muscle."( Chang, E; Jung, S; Kim, CT; Kim, IH; Kim, SY; Kim, Y; Ko, H; Lee, E; Lee, MS; Lee, S, 2019)
"The incidence of obesity is increasing among all age groups throughout the world and it is highly associated with numerous other metabolic disorders, such as insulin resistance, polycystic ovarian syndrome (PCOS) etc."( Banerjee, A; Chhabra, G; Fernandes, JRD; Krishna, A; Singh, A, 2019)
"Obesity is a worldwide health problem with rising incidence and results in reproductive difficulties."( Chan, WY; Chen, ZJ; Ke, H; Leung, PCK; Li, W; Lu, G; Qin, Y; Wang, W; Xu, L; You, L; Zhang, X; Zhao, S, 2019)
"The incidence of obesity is on the rise worldwide."( Batac, J; Glickman, L; Hamade, H; Hamade, M, 2019)
"Background Obesity is a precursor to heart failure with preserved ejection fraction."( Apovian, C; Ayalon, N; Colucci, WS; Donohue, C; Downing, J; Gokce, N; Gopal, DM; Ho, JE; Kolachalama, V; Liang, CS; Panagia, M; Perez, A; Silva, V; Siwik, D; Sverdlov, A; Wang, YC, 2019)
"Obesity is a worldwide epidemic and a common medical condition associated with a variety of chronic diseases."( Černevičiūtė, R; de Souza, NN; Hekmatdoost, A; Kord Varkaneh, H; Miri, A; Mousavi, SM; Rahmani, J; Sultana, R; Thompson, J, 2019)
"Obesity is a public health problem worldwide, and especially in women in reproductive age where more than one in three have obesity."( Carrasco-Wong, I; Casanello, P; Hernández, C; Jara-Gutiérrez, C; Porras, O, 2019)
"Human obesity is associated with vascular endothelial dysfunction, caused by a reduced nitric oxide availability secondary to an enhanced oxidative stress production."( Bernardini, N; Blandizzi, C; Chiriacò, M; Colucci, R; Masi, S; Puxeddu, I; Taddei, S; Uliana, M; Virdis, A, 2019)
"In particular, obesity is an established risk factor for PCa."( Battaglia, M; Bettocchi, C; Buonerba, C; Cantiello, F; De Cobelli, O; Di Lorenzo, G; Ditonno, P; Ferro, M; Loizzo, D; Lucarelli, G; Rutigliano, M; Terracciano, D; Vartolomei, MD, 2019)
"Obesity is a major public health challenge and exacerbates economic disparities through employment discrimination and increased personal health expenditures."( Goldstein, NJ; Jay, M; Ladapo, JA; Orstad, SL; Shu, SB; Sweat, V; Tseng, CH; Wali, S; Wittleder, S; Wylie-Rosett, J, 2019)
"Obesity is increasingly causing lifestyle diseases in developed countries where helminthic infections are rarely seen."( Hisaeda, H; Imai, T; Obi, S; Olia, A; Shibata, M; Shimokawa, C; Suzue, K, 2019)
"Obesity is known to impact reproductive function in adults, but little is known about its effects on reproductive hormones during puberty."( Hilkin, A; Kelsey, MM; Nadeau, KJ; Nokoff, N; Pyle, L; Santoro, N; Thurston, J; Zeitler, PS, 2019)
"Sarcopenic obesity is a new medical challenge that imposes tremendous financial burdens on healthcare authorities worldwide."( Chen, K; Hou, P; Huang, Y; Lang, H; Mi, M; Ran, L; Yi, L; Zhang, Q; Zhang, Y; Zheng, J; Zhou, M; Zhu, X, 2019)
"Sarcopenic obesity is a new medical challenge that imposes tremendous financial burdens on healthcare authorities worldwide."( Chen, K; Hou, P; Huang, Y; Lang, H; Mi, M; Ran, L; Yi, L; Zhang, Q; Zhang, Y; Zheng, J; Zhou, M; Zhu, X, 2019)
"Obesity is associated with reduced physiological responses to leptin and insulin, leading to the concept of obesity-associated hormonal resistance."( Balland, E; Chen, W; Cowley, MA; Tiganis, T, 2019)
"Dietary obesity is primarily attributed to an imbalance between food intake and energy expenditure."( Kleinridders, A; Pothos, EN, 2019)
"Obesity is one of the most important health problems worldwide."( Chen, H; Fan, S; Huang, C; Li, H; Li, J; Liu, C; Liu, Y; Zhou, Z, 2019)
"Obesity is a serious public health issue in developed countries, and is known to increase the risk of several diseases such as diabetes, cardiovascular events and arteriosclerosis."( Fukui, K; Kato, Y; Ninuma, T; Shirai, M, 2019)
"Overweight and obesity are a worldwide pandemic affecting billions of people."( Abreu, AR; Campos, GSV; Chianca, DA; Chírico, MTT; De Menezes, RCA; Figueiredo, AB; Lima, PM; Lowry, CA; Noronha, SSR; Silva, FCS, 2019)
"Obesity is a chronic condition associated with poorer cognitive functioning."( Bieliński, M; Borkowska, A; Junik, R; Kamińska, A; Lesiewska, N; Tretyn, A, 2019)
"Obesity is induced in male C57BL/6 mice fed a high-fat diet for 11 weeks."( Jeon, TI; Jung, CH; Kang, MJ; Lee, S; Moon, C; Moon, JH; Nguyen, TTP; Truong, XT, 2019)
"Weight gain and obesity are associated with increased levels of proinflammatory cytokines."( Addington, AK; Bruno, RS; England, KM; Fausnacht, DW; Griffin, LE; Hughes, MD; Neilson, AP; O'Keefe, SF; Racine, KC; Stewart, AC; Tuzo, JL; Zhang, H, 2019)
"Obesity is a chronic condition associated with low-grade inflammation, and it also involves alterations of the function of the hypothalamic-pituitaryadrenal axis and the sympathetic nervous system."( Álvarez-Barrientos, A; Gálvez, I; Hinchado, MD; Martín-Cordero, L; Ortega, E, 2019)
"Obesity is a major global health concern and induces numerous complications, such as heart and kidney injury."( Bai, B; Chen, H; Liang, G; Liu, H; Shan, X; Sun, C; Wu, B; Zhang, W; Zhang, Y, 2019)
"Obesity is a progressive, chronic disease, which can be caused by long-term miscommunication between organs."( Borcherding, AF; Heier, C; Kühnlein, RP; Roeder, T; Tian, G; Xu, Y, 2019)
"Obesity is associated with an increased incidence of high-grade prostate cancer (PC) and worse prognosis for PC patients."( Bhardwaj, P; Dannenberg, AJ; Elemento, O; Falcone, DJ; Giri, DD; Ikeda, T; Miyazawa, M; Mukherjee, S; Scherr, DS; Verma, A; Wang, H; Wendel, NK; Zheng, XE; Zhou, XK, 2019)
"Obesity is a rapidly growing epidemic, with over one-third of the global population classified as overweight or obese."( Dening, TJ; Gustafsson, H; Joyce, P; Kovalainen, M; Meola, TR; Prestidge, CA, 2019)
"Obesity is associated with an increased risk of depression."( Baeza-Raja, B; Baillie, GS; Day, JP; Houslay, MD; Ryu, JK; Syme, C; Vagena, E; Walsh, NM, 2019)
"Obesity is a complex disorder of excessive adiposity, and is associated with adverse health effects such as cardiometabolic complications, which are to a large extent attributable to dysfunctional white adipose tissue."( Goossens, GH; Lempesis, IG; Manolopoulos, KN; van Meijel, RLJ, 2020)
"Obesity is a complex disease resulting in several metabolic co-morbidities and is increasing at epidemic rates."( Bonaldo, M; Costa, M; Eiríksson, F; Gonçalves Silva, N; Hernandez-Bautista, R; Ribeiro, T; Rosa, F; Thorsteinsdóttir, M; Urbatzka, R; Ussar, S, 2019)
"Obesity is a worldwide epidemic, which is characterized by the excess accumulation of adipose tissue and to an extent that impairs both the physical and psychosocial health and well-being."( Carrasco-Pozo, C; Cires, MJ; Gotteland, M, 2019)
"Canine obesity is a relevant disease always accompanied with several health conditions such as inflammation, immune-dysregulation, insulin resistance, pancreatitis, orthopaedic disorders, cardiovascular disease, and neoplasia."( Cortese, L; Pelagalli, A; Terrazzano, G, 2019)
"Obesity is associated with insulin resistance and type 2 diabetes."( Ahima, RS; Dias, JP; Rowe, SP; Santhanam, P, 2019)
"Obesity is a major cause of metabolic syndrome and type II diabetes, and it presents with metabolic disorders, such as hyperglycemia, hyperlipidemia, and insulin resistance."( Chen, CC; Lee, TY; Leu, YL; Wang, SH, 2019)
"Obesity is characterized by chronic low-grade inflammation that contributes to development of cardiometabolic disorders."( Mehrpouya-Bahrami, P; Miranda, K; Nagarkatti, M; Nagarkatti, PS, 2019)
"Common forms of obesity are associated with increased leptin levels and a failure to suppress feeding and mediate weight loss in response to exogenous leptin."( Hristov, M; Landzhov, B; Nikolov, R; Yakimova, K, 2019)
"Obesity is often associated with changes in cardiac function; however, the mechanisms responsible for functional abnormalities have not yet been fully clarified."( Campos, DHS; Cicogna, AC; Deus, AF; Okoshi, K; Padovani, CR; Silva, DCT; Tomasi, LC; Vileigas, DF, 2019)
"Obesity is a chronic metabolic disorder that is associated with higher risks of developing diabetes and cardiovascular disease."( Gao, X; Song, P; Sun, Y; Wang, H; Wang, Y; Xu, N; Yue, P; Zhang, Z, 2019)
"Obesity is a risk factor for asthma, especially nonatopic asthma, and attenuates the efficacy of standard asthma therapeutics."( Abu-Ali, G; Brand, JD; Bry, L; Cho, Y; Huttenhower, C; Kasahara, DI; Shore, SA; Tashiro, H; Yeliseyev, V, 2019)
"Obesity is a medical and sociological problem of great importance due to the high percentage of people affected and the important health consequences that it involves."( Carrera, S; Drehmer, E; Moreno, ML; Navarro-Moreno, MÁ; Villar, VM, 2019)
"Overweight and obesity are risk factor of CVD and type 2 diabetes mellitus (T2DM)."( Bochar, O; Bondarenko, O; Karpyshyn, N; Maksymets, T; Sklyarov, Y; Sorochka, M, 2019)
"Obesity is one of the actual problems of modern medicine."( Golodnikov, II; Kamalov, AA; Nizov, AN; Pavlova, ZS, 2019)
"Obesity is frequently present in these patients and plays a key role in the pathogenesis of both the endocrine and metabolic abnormalities of the syndrome, particularly infertility, hyperandrogenism and insulin resistance (IR)."( Chatzis, P; Dinas, K; Makris, V; Pratilas, GC; Sotiriadis, A; Tziomalos, K, 2018)
"Obesity is associated with increased incidence and worse prognosis of more than one dozen tumor types; however, the molecular mechanisms for this association remain under debate."( Perry, RJ; Rabin-Court, A; Rodrigues, MR; Zhang, XM, 2019)
"Introduction: obesity is associated with high levels of oxidative stress (OS) and inflammation."( Cortes-Oliveira, C; Delfino, HBP; Frantz, FG; Marchini, JS; Nicoletti, CF; Nonino, CB; Noronha, NY; Oliveira, BAP; Pinhanelli, VC; Pinhel, MAS; Quinhoneiro, DCG; Wolf, LS, 2019)
"Obesity is associated with impaired intestinal epithelial barrier function and an altered microbiota community structure, which contribute to host systemic inflammation and metabolic dysfunction."( Graf, D; Hutchinson, AL; Lepp, D; Liddle, DM; Monk, JM; Pauls, KP; Power, KA; Robinson, LE; Wellings, HR; Wu, W, 2019)
"Obesity is a metabolic syndrome worldwide that causes many chronic diseases."( Liu, J; Liu, L; Luo, J; Luo, Z; Peng, X; Qi, J; Wang, W; Zhang, G; Zhou, Q, 2019)
"Obesity is associated with microvascular dysfunction."( Bian, JT; Gutterman, DD; Hwang, CL; Mahmoud, AM; Phillips, SA; Ranieri, C; Szczurek, MR, 2019)
"The causes of obesity are complex and multifactorial."( Blair, C; Kuzawa, CW, 2019)
"Diabetes and obesity are the two notorious metabolic disorders in today's world."( Mishra, M; Nayak, N, 2019)
"Women with obesity are more likely to have a complicated reproductive life."( Ghanem, M; Harphoush, S; Le, G; Qiuli, G; Shi, Y; Wu, G; Zaitoun, M, 2019)
"Obesity is unexpectedly associated with improved outcomes with immune and targeted therapy in melanoma, with early mechanistic data suggesting leptin as one mediator."( McQuade, JL; Warner, AB, 2019)
"Obesity is associated with milder rates of inadequate LT4 treatment compared with nonobese populations."( Aimaretti, G; Biondi, B; Marzullo, P; Mele, C; Pagano, L; Scacchi, M; Soranna, D; Tagliaferri, MA, 2019)
"Obesity is considered a chronic inflammatory disease, the inflammatory factors, such as interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1) and small inducible cytokine A5 (RANTES), are elevated in obese individuals."( Chen, XM; Gong, HZ; Hong, A; Ma, Y; Qiu, P; Sun, Y; Xiao, X, 2019)
"Obesity is a major worldwide health threat."( Costa, AGV; Garcia-Diaz, DF; Jimenez, P; Reyes-Farias, M; Soto-Covasich, J, 2019)
"The prevalence of obesity is rising worldwide and obese patients comprise a specific population in the intensive care unit."( Choi, AM; Cloonan, SM; Cohen, DE; Fan, L; Huang, Z; Imamura, M; Plataki, M; Sanchez, E; Torres, LK; Zhu, Y, 2019)
"Obesity is associated with ~40% of cancer diagnoses but there are currently no effective preventive strategies, illustrating a need for chemoprevention."( Benham, V; Bernard, JJ; Bernard, MP; Bullard, B; Dexheimer, TS; Liby, KT; Neubig, RR, 2019)
"Obesity is characterized by a state of chronic low-grade inflammation associated to metabolic dysfunction."( Leite, F; Ribeiro, L, 2020)
"Obesity is not only associated with metabolic diseases but is also a symptom of menopause in women."( Chen, SY; Cheng, PY; Kung, CW; Lee, YM; Leu, SY; Liu, YP; Tsai, YC; Yen, MH, 2019)
"Obesity is one of the major public health problems worldwide, mainly resulting from unhealthy lifestyles and diet."( Duan, Y; Huang, Y; Kang, D; Su, M, 2019)
"Obesity is a complex disorder that is influenced by genetic and environmental factors."( Becer, E; Kalkan, R, 2019)
"Obesity is a severe medical problem endangering the health of individuals worldwide."( Cai, Q; Ding, X; Fu, H; Huang, R, 2019)
"Obesity is already responsible for 300,000 deaths per year."( Kleniewska, P; Pawliczak, R, 2019)
"Obesity is a major health concern worldwide and is considered to be associated with disruption of host-microbial homeostasis, especially microbiota composition in the gastrointestinal tract."( Chen, F; Chen, T; Cheng, KW; Guo, B; Pang, X; Yang, B, 2019)
"Obesity is mainly caused by the imbalance of energy intake and consumption in the body."( Feng, Q; Hong, Y; Huang, Z; Lu, Z; Zheng, M, 2019)
"Obesity is a globally widespread metabolic disorder, characterized by immoderate fat accumulation in the body."( Chung, JY; Kim, OY; Song, J, 2019)
"Obesity is known to be associated with impaired testicular function potentially resulting in androgen deficiency and subfertility."( Hill, A; Pearce, K; Tremellen, K, 2019)
"Obesity is one of the major health problems worldwide."( Buhlmann, E; Horváth, C; Houriet, J; Kiehlmann, E; Marcourt, L; Radtke, J; Schröder, S; Wolfender, JL; Wolfrum, C, 2019)
"Obesity is a major cardiovascular risk factor which dramatically impairs endothelium- dependent vasodilation and leads to hypertension and vascular damage."( Berra-Romani, R; Faris, P; Moccia, F; Negri, S, 2020)
"Obesity is known to induce a state of lipotoxicity that affects the different organs of the body."( El-Sayed, SM; Ibrahim, HM, 2020)
"Obesity is defined as a condition of abnormal or excessive fat accumulation in white adipose tissue that results from the exacerbated consumption of calories associated with low energy expenditure."( Alonso-Vale, MIC; Antraco, VJ; Cruz, MM; de Sa, RDCDC; Farias, TDSM; Paixao, RID; Simão, JJ, 2019)
"Obesity is one of the strongest modifiable risk factors for late-onset hypogonadism, and coexisting diabetes leads to further hypothalamic-pituitary-testicular axis suppression."( Cheung, AS; Grossmann, M; Ng Tang Fui, M, 2020)
"Obesity is a prevalent public health problem, and food addiction (FA) is one of the most controversial factors in its management."( Abolhasani, M; Amiri, P; Ghorbani, A; Hosseinzadeh, N; Moghaddam, SAP; Saidpour, A, 2019)
"Obesity is the major risk factor for several cardiovascular and metabolic disorders."( Bader, M; Barreto-Chaves, MLM; de Oliveira Silva, T; Diniz, GP; Fonseca, RIB; Júnior, JD; Lima, VM; Lino, CA; Santos, RAS; Senger, N, 2019)
"Obesity is known to be associated with intestinal barrier dysfunction driven by hyperglycemia and gut dysbiosis."( Ao, M; Li, F; Li, Y; Liu, R; Tao, Z; Xu, H; Yao, Y; Yu, L; Zhao, C, 2019)
"Obesity is a complex disease of great public health significance worldwide: It entails several complications including diabetes mellitus type 2, cardiovascular dysfunction and hypertension, and its prevalence is increasing around the world."( Jablonska, M; Malinowska, K; Merecz-Sadowska, A; Sitarek, P; Sliwinski, T; Zajdel, K; Zajdel, R; Zielinska-Blizniewska, H, 2019)
"Obesity is a growing public health problem worldwide."( Al-Zoubi, NA; Aleshawi, AJ; Alfaqih, M; Alqudah, A; Alzoubi, A; Hatamleh, M; Mazahreh, TS; Saadeh, R, 2019)
"Obesity is a major risk factor for cardiovascular disease."( Al-Ghanam, I; Biter, LU; Castro Cabezas, M; Dunkelgrun, M; Leeman, M; van Mil, SR, 2019)
"Osteoporosis and obesity are considered civilisation diseases."( Głogowska-Szeląg, J; Kos-Kudła, B; Marek, B; Nowak, M; Siemińska, L, 2019)
"Obesity is highly heritable and arises from the interplay of many genes and environmental factors."( Aquilanti, B; Bertelli, M; Del Ciondolo, I; Gagliardi, L; Matera, G; Miggiano, GAD; Paolacci, S; Paolini, B; Pompucci, G; Scaramuzza, A; Velluti, V, 2019)
"Obesity is taking on worldwide epidemic proportions, yet effective pharmacological agents with long-term efficacy remain unavailable."( Aerts, JMFG; Boot, R; Foppen, E; Herrera Moro Chao, D; Jansen, K; Kalsbeek, A; Kooijman, S; Marques, AR; Mergen, C; Mirzaian, M; Ottenhoff, R; Overkleeft, H; Parlevliet, ET; Rensen, PCN; Scheij, S; Seeley, RJ; Tschöp, MH; van Eijk, M; van Roomen, C; Verhoek, M; Wang, D; Wang, Y; Yi, CX, 2019)
"Obesity is a public health problem that has raised concerns worldwide and is often associated with hepatic steatosis."( Chang, CJ; Cheng, KP; Du, YF; Hu, CY; Huang, RL; Li, CH; Lin, CH; Ou, HY; Wu, HT; Wu, JS, 2020)
"Obesity is caused by an imbalance between energy intake and output, influenced by numerous environmental, biological, and genetic factors."( Kleinendorst, L; van den Akker, ELT; van Haelst, MM, 2019)
"Obesity is a significant contributor to increased morbidity and premature mortality due to increasing the risk of many chronic metabolic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer."( Jack, BU; Joubert, E; Louw, J; Malherbe, CJ; Mamushi, M; Muller, CJF; Pheiffer, C, 2019)
"Obesity is a risk factor for a spectrum of unhealthy conditions including systemic metabolic dyshomeostasis."( Arteel, GE; Barnes, GN; Cai, L; Freedman, JH; Kong, M; States, JC; Watson, WH; Xu, J; Yan, X; Yin, X; Young, JL; Zhang, X, 2019)
"Obesity is closely associated with neuroinflammation in the hypothalamus, which is characterized by over-activated microglia and excessive production of pro-inflammatory cytokines."( Hochstetter, D; Mao, L; Wang, Y; Xu, P; Yao, L; Zhao, Y; Zhou, J, 2019)
"Obesity is associated with changes in the plasma lipids."( Borodulin, K; Cannistraci, CV; Fernandez, C; Gerl, MJ; Havulinna, AS; Ikonen, E; Klose, C; Männistö, S; Melander, O; Salomaa, V; Simons, K; Surma, MA, 2019)
"Obesity is considered to be a risk factor for neurodegenerative- and psychiatric- diseases including Alzheimer's disease, schizophrenia, and depression."( Fukasawa, K; Gotoh, M; Kunugi, H; Murakami-Murofushi, K; Nakajima, S, 2020)
"Obesity is an established risk factor for renal disease and for disease progression."( Cobo-Caso, MA; Delgado-Mallén, P; Díaz-Martín, L; Escamilla, B; Estupiñán, S; Folgueras, T; González-Rinne, A; González-Rinne, F; Jiménez-Sosa, A; López-Martínez, M; Luis-Lima, S; Marrero-Miranda, D; Miquel-Rodríguez, RM; Morales, E; Navarro-Díaz, M; Negrín-Mena, N; Porrini, E; Torres, A, 2020)
"Obesity is a worldwide epidemic with rates nearly doubling over the last 30 years."( Armijo, PR; Baxter, J; Flores, L; Krause, C; Samreen, S; Tanner, T, 2019)
"Obesity is a worldwide health problem."( Huang, W; Li, C; Li, H; Li, J; Liu, M; Liu, W; Song, J; Xie, S; Zhang, H, 2020)
"Moreover, obesity is traditionally viewed as leading to increased bone mass and density."( Bi, X; Henry, CJ; Loo, YT, 2020)
"Maternal obesity is associated with placental oxidative stress."( Cheng, C; Deng, J; Hu, C; Li, J; Li, Q; Liang, Z; Tan, C; Wang, H; Xie, Z; Yang, L; Yang, Y; Yin, Y, 2019)
"Obesity is associated with alterations in appetite, gastrointestinal hormone levels and excessive fat mass."( Acosta, A; Burton, DD; Camilleri, M; Chedid, V; Clark, MM; Halawi, H; Kadouh, H; Khemani, D; Vella, A, 2020)
"Obesity is a major public health issue affecting nearly 40% of American adults and is associated with increased mortality and elevated risk for a number of physical and psychological illnesses."( Donofry, SD; Erickson, KI; Stillman, CM, 2020)
"Pet obesity is on the rise, bringing with it increased risks of ill health and poor quality of life for companion animals."( , 2019)
"Obesity is a global public health issue."( Chen, WK; Ho, CT; Koh, YC; Lee, TL; Nagabhushanam, K; Pan, MH; Wang, B, 2019)
"Obesity is associated with impaired inhibitory control over food intake."( Fowler, JS; Manza, P; Shokri Kojori, E; Volkow, ND; Wang, GJ; Wiers, CE; Wong, CT; Yuan, K, 2020)
"Obesity is associated with reduced operating lung volumes that may contribute to increased airway closure during tidal breathing and abnormalities in ventilation distribution."( Bailey, DL; Chapman, DG; Dame Carroll, JR; Farrow, CE; King, GG; Mahadev, S; Rutting, S; Thamrin, C; Tonga, KO, 2020)
"Obesity is a global health problem associated with several diseases including ocular complications."( Ayyagari, R; Godisela, KK; Kumar, CU; Reddy, GB; Reddy, PY; Reddy, SS; Reddy, VS, 2020)
"Although obesity is known to be critical for cancer development, how obesity negatively impacts antitumor immune responses remains largely unknown."( Aftabizadeh, M; Chu, P; Egelston, C; Forman, S; Herrmann, A; Hoon, DSB; Huang, W; Kruper, L; Lee, H; Lee, PP; Li, W; Li, YJ; Mortimer, J; Priceman, S; Somlo, G; Song, J; Wang, T; Yu, H; Yue, C; Zhang, C; Zhang, Z, 2020)
"Overweight and obesity are increased risk for deficiency of vitamin particularly shortage of fat soluble-vitamins."( Al-Jafary, MA; Al-Suhaimi, EA, 2020)
"Obesity is associated with low serum 25-hydroxyvitamin D [s25(OH)D], high serum leptin, and generally high bone mineral density (BMD)."( Gao, Y; Glowacki, J; Gorska, A; Lange, JK; LeBoff, MS; Li, J; Luu, S; Yu, T; Zhou, S, 2020)
"Obesity is often accompanied by dyslipidemia, high blood glucose, hypertension, atherosclerosis, and myocardial dysfunction."( He, Z; Jiang, T; Xu, J; Xu, M; Xue, F; Zhang, S, 2019)
"Obesity is considered a global epidemic and is mainly associated with the development of diabetes, cardiovascular diseases and Non-Alcoholic Fatty Liver (NAFLD)."( Aguirre-Maldonado, I; Alexander-Aguilera, A; Deschamps-Lago, RA; Gruber-Pagola, P; Juárez-Rivera, VE; Quintana-Castro, R; Ramos-Manuel, LE; Soto-Rodríguez, I; Urbina de Larrea, YK, 2020)
"Obesity is characterized by a blunted lipolytic response in abdominal subcutaneous adipose tissue (SAT) and low circulating vitamin D levels."( Blaak, EE; Goossens, GH; Jocken, JWE; Pramono, A, 2019)
"Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment."( Aylor, KW; Barrett, EJ; Hartline, L; Jahn, LA; Lin, S; Liu, Z; Patrie, JT; Tan, AWK; Wang, N, 2020)
"Obesity is considered a serious chronic disease, associated with an increased risk of developing cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes."( Budzynski, A; Dolicka, D; Jankowska, U; Jura, J; Kedracka-Krok, S; Kulecka, M; Losko, M; Major, P; Mikula, M; Paziewska, A; Pydyn, N; Winiarski, M, 2020)
"Obesity is a complex, chronic disease that arises according to the interaction between genetic and environmental factors."( Culum, AA; Yurekli, M, 2020)
"Obesity is a worldwide prevalent metabolic disorder that is associated with diabetes, among many other diseases."( Deng, Y; Papukashvili, D; Rcheulishvili, N, 2020)
"Obesity is associated with chronic inflammation and cognitive decline, and is considered a major risk factor for neurodegeneration."( Chen, J; Fu, X; Jiang, L; Ren, H; Su, L; Wang, C; Wang, Y, 2019)
"Obesity is a major health problem and is known to be closely associated with metabolic diseases."( Choi, WJ; Dong, HJ; Jeong, HU; Jung, HH; Kim, TH; Kim, YH; Kim, YR; Ryu, DW; Song, SM, 2020)
"Obesity is a multifactorial chronic disease that comprises several pathological events, such as adipose hypertrophy, fatty liver and insulin resistance."( Ababneh, Q; Alsaggar, M; Alzoubi, KH; Bdour, S; El-Elimat, T; Qinna, N, 2020)
"Obesity is linked with insulin resistance and is characterized by excessive accumulation of adipose tissue due to chronic energy imbalance."( Chan, EJ; Crane, ED; Crane, JD; Day, EA; Desjardins, EM; Khan, WI; Leroux, JM; Morrison, KM; Steinberg, GR; Wang, B; Wong, W; Yabut, JM, 2020)
"The prevalence of obesity is rapidly increasing, so much so that the World Health Organization has declared obesity as a global epidemic."( Carrier, M; Wang, TF, 2020)
"Ageing and obesity are both linked to a chronic proinflammatory state and elevated oxidative stress, which have both been implicated in cardiovascular and neurodegenerative diseases."( Aldred, S; Elsworthy, RJ, 2020)
"Obesity is a major risk factors for type 2 diabetes, and weight loss is beneficial to diabetic patients who are obese or overweight."( Furusawa, K; Kitamura, T; Kohno, D, 2020)
"Obesity is a chronic metabolic disease caused by multiple factors and is considered to be a risk factor for type 2 diabetes, cardiovascular disease, hypertension, stroke and various cancers."( Gan, Q; Hu, J; Huang, Q; Lou, G; Peng, C; Ran, Q; Sun, J; Wang, J; Xiong, H; Yao, R, 2019)
"Obesity is a major public health concern worldwide."( Barba de la Rosa, AP; Blas-Y-Estrada, F; Del Socorro Santos-Diaz, M; Fouché, E; Guéraud, F; Héliès-Toussaint, C; Naud, N; Nègre-Salvayre, A, 2020)
"Severe obesity is a significant risk factor for developing of T2DM in PWS."( Crinò, A; Grugni, G, 2020)
"The prevalence of obesity is alarmingly increasing in the last few decades and leading to many serious public health concerns worldwide."( Mohankumar, SK; Palaniswamy, D; Rajan, L, 2020)
"Obesity is related with the increased lipid accumulation in white adipose tissue, which is a major risk factor for the development of metabolic disorders, such as type 2 diabetes and cardiovascular disease."( Ariyani, W; Koibuchi, N; Lizcano, F; Miyazaki, K; Miyazaki, M; Okada, J; Sato, T; Shimokawa, N; Uchida, K; Vargas, D, 2020)
"Obesity is a chronic disease, warranting long-term medical intervention."( Doros, G; Haider, A; Haider, KS; Saad, F, 2020)
"Obesity is one of the greatest public health challenges of modern times and its prevalence is increasing worldwide."( Briers, B; Chan, E; Huh, YE; Mukhopadhyay, A, 2020)
"Obesity is considered as an indispensable component of metabolic health assessment and metabolic syndrome diagnosis."( Fronczek, M; Gąsior, M; Gawlita, M; Lejawa, M; Lonnie, M; Osadnik, K; Osadnik, T; Pawlas, N; Reguła, R; Wądołowska, L, 2020)
"Obesity is a chronic metabolic disease resulting from excessive fat accumulation and/or abnormal distribution caused by multiple factors."( Hu, Y; Khadka, RB; Liu, M; Peng, X; Yang, J; Yun, P, 2020)
"Obesity is an important equine welfare issue."( Argo, CM; Barfoot, C; Dugdale, AH; Grove-White, DH; Harris, PA; Jones, E; Morrison, PK; Newbold, CJ; Worgan, HJ, 2020)
"Childhood obesity is a major risk factor for heart disease during adulthood, independent of adulthood behaviours."( Boldt, K; Herzog, W; Joumaa, V; MacDonald, G, 2020)
"Obesity is associated with an increased risk of several major noncommunicable diseases, and is an important public health concern globally."( Ostadrahimi, A; Saghafi-Asl, M; Tutunchi, H, 2020)
"Obesity is associated with metabolic abnormalities, including insulin resistance and dyslipidemias."( Arteaga-Sanchez, L; Gamba, G; Godinez-Salas, ET; Granados, O; Guevara-Cruz, M; Guizar-Heredia, R; López-Barradas, A; Mojica-Espinosa, R; Noriega, LG; Pichardo-Ontiveros, E; Sanchez-Tapia, M; Schcolnik-Cabrera, A; Torre-Villalvazo, I; Torres, N; Torres-Villalobos, G; Tovar, AR; Vargas-Castillo, A, 2020)
"Obesity is a major health concern in postmenopausal women, and chronic low-grade inflammation contributes to the development of obesity."( Alhaj-Saleh, A; Aryaie, A; Lee, J; Moore, L; Shankar, K; Shen, CL; Tinsley, G; Wang, R; Watkins, BA; Wood, SR, 2020)
"Diet-induced obesity is the most widely used animal model for studying nonalcoholic fatty liver disease (NAFLD)."( Chen, TH; Chen, YH; Chiu, CC; Chiu, CF; Chuang, HL; Huang, CC; Huang, WC; Hung, SW; Lee, YP; Wang, YC, 2020)
"Obesity is a major health challenge facing many people throughout the world."( Borgland, SL; Seabrook, LT, 2020)
"Abdominal obesity is more closely associated with diabetes than general obesity in adults, however, it is unknown which kind of obesity is more closely associated with abnormal glucose metabolism in children."( Baccarelli, AA; Gu, Y; Hou, L; Hu, G; Leng, J; Li, W; Liu, H; Liu, J; Lu, J; Wang, L; Wang, S; Zhang, S, 2020)
"Obesity is characterized by abnormal or excessive lipid accumulation (World Health Organization, WHO) resulting from pre-adipocyte differentiation (adipogenesis)."( Huh, JW; Kim, JY; Kim, MH; Lee, DS; Lee, HJ; Lee, HS; Lee, SR, 2020)
"Obesity is linked to fertility dysfunction in both genders."( Arora, H; Khodamoradi, K; Khosravizadeh, Z; Kuchakulla, M; Manoharan, M; Parmar, M, 2020)
"Background: obesity is a chronic disease associated with inadequate eating habits and reduced levels of physical activity."( Campos, RMDS; Dâmaso, AR; Duca, LL; Lombardi, JAB; Machado, PP; Masquio, DCL; Oliveira, GI; Oyama, LM; Rhein, SO; Shiba, CK; Tock, L, 2020)
"Obesity is becoming one of the greatest threats to global health in the 21st century and therefore the development of novel antiobesity drugs is one of the top priorities of global drug research."( Almasri, IM, 2020)
"Obesity is a major cause of morbidity and mortality."( Buckley, NW; Cai, M; Cheetham, S; Counsell, JR; Dhillo, WS; Farooq, G; Fernandes-Freitas, I; Gardiner, J; Izzi-Engbeaya, C; Ma, Y; Mirza, Z; Murphy, K; Norton, M; Ratnasabapathy, R; Richardson, E; Seckl, J, 2020)
"Obesity is characterized by a resistance to appetite-regulating hormones, leading to a misalignment between the physiological signals and the perceived hunger/satiety signal."( Barberá Ortega, MDC; Díaz Soler, I; Hernández Morante, JJ; Martínez, CM; Morillas Ruiz, JM; Muñoz, JSG; Sánchez, HP, 2020)
"Background Obesity is a risk factor for medical complications, including the cardiovascular system."( Alves, CAB; Campos, DHS; Cicogna, AC; Deus, AF; Freire, PP; Mota, GAF; Padovani, CR; Silva-Bertani, DCTD; Souza, SLB; Tomasi, LC; Vileigas, DF, 2020)
"Obesity is a risk factor for surgical site infection after cesarean delivery."( Christensen, R; Eley, VA; Jackson, D; Lipman, J; Parker, SL; Roberts, JA; Ryan, R; Smith, M; van Zundert, AA; Wallis, SC, 2020)
"Obesity is commonly associated with hyperglycemia and type 2 diabetes and negatively affects chromium accumulation in tissues."( Chang, GR; Chen, WK; Hou, PH; Lin, CT; Mao, FC; Tsai, HP, 2020)
"Obesity is characterized by fat accumulation, chronic inflammation and impaired satiety signaling, which may be due in part to gut microbial dysbiosis."( Barile, D; Goodson, M; Kalanetra, K; Lee, S; Raybould, H; Vang, W, 2020)
"Obesity is associated with differences in task-evoked and resting-state functional brain connectivity (FC)."( Donofry, SD; Erickson, KI; Jakicic, JM; Roecklein, KA; Rogers, RJ; Watt, JC, 2020)
"Abdominal obesity is one of the main modifiable risk factors of age-related cardiometabolic disease."( Akker, EBVD; Beekman, M; de Geus-Oei, LF; Deelen, J; Dibbets-Schneider, P; Feskens, EJM; Heemst, DV; Noordam, R; Rest, OV; Schutte, BAM; Slagboom, PE, 2020)
"Obesity is one of the main causes of human cardiovascular and cerebrovascular diseases."( Jiang, YQ; Jiang, ZM; Liu, EH; Liu, WJ; Wang, ZY; Xiao, PT, 2020)
"The epigenetics of obesity is an expanding area of research, and current reports suggest potential in the use of epigenetic mechanisms as clinical biomarkers and therapeutic candidates."( Herrero, L; Mera, P; Obri, A; Serra, D, 2020)
"Obesity is a disease of increasing prevalence."( Benson, M; Caldis, M; Gopal, D; Hubers, J; Pfau, P, 2020)
"Obesity is a risk factor for endometrial hyperplasia and EC development."( El-Dorf, A; El-Saka, AM; Zamzam, YA, 2020)
"Obesity is associated with the activation of cellular responses, such as endoplasmic reticulum (ER) stress."( Aintablian, A; Bouret, SG; Coupe, B; Park, S, 2020)
"Obesity is associated with poorer responses to chemo- and radiation therapy for breast cancer, which leads to higher mortality rates for obese women who develop breast cancer."( Bunnell, BA; Denys, A; Freeman, BT; Harrison, MAA; Hartono, AB; Hossain, F; Miele, L; Sabol, RA; Sandler, MB; Villela, VA; Wise, RM, 2020)
"Obesity is usually associated with chronic low-grade inflammation and may lead to the onset and progression of myocardial fibrosis and remodeling."( Chen, GZ; Fu, LL; Liang, G; Liu, Q; Lu, XY; Sun, CC; Zhang, XH; Zheng, XY, 2020)
"Obesity is associated with infertility, decreased ovarian performance and lipotoxicity."( Adamowski, M; Castillo-Fernandez, J; Galvão, A; Kelsey, G; Walewska, E; Wołodko, K, 2020)
"Obesity is an independent risk factor for cardiovascular diseases (CVD), including heart failure."( Gupte, M; Lal, H; Singh, AP; Tousif, S; Umbarkar, P; Zhang, Q, 2020)
"Obesity is a growing problem in UK equine population."( Dosi, MCM; Hallsworth, S; Keen, JA; Kirton, R; Morgan, RA, 2020)
"Type 2 diabetes and obesity are associated with back pain in juveniles and adults and are implicated in intervertebral disc (IVD) degeneration."( Hoy, RC; Iatridis, JC; Illien-Jünger, S; Krishnamoorthy, D; Lai, A; Natelson, DM, 2020)
"Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes."( Błachnio-Zabielska, A; Chacińska, M; Kojta, I, 2020)
"Obesity is a health problem affecting more than 40% of US adults and 13% of the global population."( Alexopoulos, SJ; Beretta, M; Brandon, AE; Byrne, FL; Carrive, P; Chen, SY; Cooney, GJ; Garcia, CJ; Hargett, SR; Hoehn, KL; Lackner, C; Lawrence, RT; Lee, B; Olzomer, EM; Philp, A; Philp, AM; Salamoun, JM; Santos, WL; Shah, DP; Sligar, J; Tucker, SP; Turner, N, 2020)
"Obesity is a top public health concern, and a molecule that safely treats obesity is urgently needed."( Ali, A; Aon, MA; Becker, KG; Bernier, M; Cai, H; Cogger, VC; Cuervo, AM; de Cabo, R; Di Francesco, A; Di Germanio, C; Diaz, A; Egan, JM; Enamorado, IN; Fernandez-Hernando, C; Fishbein, K; Gao, B; Guiterrez, V; Harney, D; Kaiser, T; Kim, EY; Koay, YC; Lakatta, EG; Larance, M; LeCouteur, DG; Mach, J; Mitchell, SJ; O'Sullivan, J; Petr, MA; Price, NL; Pulpitel, T; Seo, W; Singh, A; Spencer, RG; Wahl, D; Wang, M; Wang, Y; Warren, A; Zhang, J; Zhang, L, 2020)
"Obesity is a malnourishment epidemic worldwide."( Cirillo, PM; Cohn, BA; Krigbaum, NY; La Merrill, MA, 2020)
"Although obesity is a metabolic disease, behavioral aspects are important in its etiology."( Bluemel, S; Ernst, M; Fried, M; Martin-Soelch, C; Milos, G; Müller-Pfeiffer, C; Piccolo, M; Schumacher, S, 2020)
"Obesity is a major cause of non-alcoholic fatty liver disease (NAFLD)."( Berry, DL; Cheema, A; Chung, FL; Coia, H; Cruz, MI; Girgis, M; Hou, Y; Lee, Y; Ma, N; Pannkuk, E; Permaul, E; Rodriquez, O; Zhu, Z, 2021)
"Obesity is responsible for an increased risk of sub-fecundity and infertility."( Cena, H; Chiovato, L; Nappi, RE, 2020)
"Obesity is a major public health concern and overconsumption of unhealthy fats and sugary beverages are contributing factors."( Ahmed, B; Graff, EC; Greene, MW; Haynes, W; Neinast, CE; Woodie, LN, 2020)
"Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes."( Lungkaphin, A; Promsan, S, 2020)
"Obesity is associated with a substantially higher risk of incident chronic opioid use."( Baker, JF; England, BR; George, M; Michaud, K; Mikuls, TR; Pedro, S; Sayles, H; Stokes, A; Wolfe, F, 2021)
"Obesity is a major cause of insulin resistance and diabetes."( Birnbaumer, L; Gnad, T; Häring, HU; Kaur, J; Kerner, J; Leiss, V; Machann, J; Nürnberg, B; Pfeifer, A; Sartorius, T; Schick, F; Schönsiegel, A, 2020)
"Obesity is associated with germ cell apoptosis, spermatogenesis arrest, and testicular endocrine suppression."( Habibi Maleki, A; Moshari, S; Razi, M; Tolouei Azar, J, 2020)
"Obesity is closely related to thyroid hormones; however, the relationship between abdominal fat distribution and thyroid hormones has rarely been explored."( Bao, Y; Ma, X; Nie, X; Wang, Y; Xiao, Y; Xu, Y, 2020)
"Prolonged obesity is associated with blunted feeding and thermogenic autonomic responses to leptin, but cardiovascular responses to leptin are maintained."( Balapattabi, K; Cui, H; Deng, G; Grobe, JL; Knudtson, KL; Kwitek, AE; Morselli, LL; Rahmouni, K; Sapouckey, SA; Sigmund, CD; Wagner, VA, 2020)
"Obesity is a major risk factor in aetiology of type 2 diabetes mellitus (T2DM)."( Badaruddoza, B; Bains, V; Kaur, H, 2020)
"Obesity is related to osteoarthritis (OA)."( Hu, Z; Liu, H; Shang, P; Tang, Q; Tang, S; Xu, J; Yu, X; Zheng, G, 2020)
"Obesity is a chronic recurring disease whose prevalence has almost tripled over the past 40 years."( Grill, HJ, 2020)
"Obesity is a leading cause of preventable death worldwide."( Alexopoulos, SJ; Axelrod, CL; Beyl, R; Dantas, WS; Davuluri, G; Doyle, H; Fealy, C; Fitzgerald, K; Fujioka, H; Hall, J; Hoehn, KL; Hoppel, CL; Hull, M; King, WT; Kirwan, JP; Langohr, I; Mey, JT; Mulya, A; Nieuwoudt, S; Noland, RC; Pergola, K; Schmidt, E; Stadler, K; Zunica, ER, 2020)
"Obesity is associated with lung function impairment and respiratory diseases; however, the underlying pathophysiological mechanisms are still elusive, and therapeutic options are limited."( Ahrendt, N; Eisenberg, T; Lopez-Rodriguez, E; Madeo, F; Magnes, C; Mühlfeld, C; Ochs, M; Rajces, A; Schipke, J; Schmiedl, A; Sedej, S; Steingrüber, T, 2020)
"Obesity is a risk factor for postoperative pulmonary complications (PPCs)."( Li, T; Li, XX; Liu, S; Wang, XH; Wang, XL; Zeng, S; Zhao, Y, 2020)
"Obesity is associated with altered fatty acid profiles, reduced fertility, and assisted reproductive technology (ART) success."( Betts, DH; Calder, MD; Crocker, K; Du, JT; Rafea, BA; Ruetz, KN; Urquhart, BL; Watson, AJ; Yousif, MD, 2020)
"Obesity is associated with breast cancer aggressiveness and drug resistance."( Afrisham, R; Eivazi, N; Emamgholipour, S; Izadi, P; Paknejad, M; Sadegh-Nejadi, S; Tahbazlahafi, B, 2020)
"Obesity is defined as a chronic disease, and is known as a public health problem in developed and developing countries."( Ahmadi-Angali, K; Helli, B; Mohammadshahi, M; Ravanbakhsh, M; Zakizadeh, E, 2021)
"Obesity is a metabolic disorder that results from complex interactions between genetic predisposition and dietary factors."( Chang, YH; Chen, CJ; Chen, WY; Hong, CJ; Hsiao, CW; Liao, SL; Lin, SY; Lo, YL; Wang, YY; Yang, CP, 2020)
"Obesity is an independent risk factor to develop cardiac functional and structural impairments."( Di Lascio, N; Faita, F; Forini, F; Kusmic, C; L'Abbate, S; Marchetti, S; Nicolini, G, 2020)
"Obesity is an important predictor of COVID-19 severity in young patients."( Dai, Z; Deng, L; Deng, M; Li, Z; Meng, Z; Qi, Y; Tang, J; Wang, H; Xu, Y, 2020)
"Sex and obesity are independently associated with residual viremia in people on long-term ART."( Bosch, RJ; Collier, AC; Cyktor, JC; Eron, JJ; Gandhi, RT; Godfrey, C; Hogg, E; Macatangay, BJ; Mar, H; McMahon, DK; Mellors, JW, 2021)
"Obesity is associated with an increased risk of developing cardiovascular disease (CVD), with limited alterations in cardiac genomic characteristics known."( Chen, X; Guan, X; Hui, W; Men, L; Song, T; Wang, X; Zhang, S, 2020)
"Obesity is a worldwide epidemic responsible for 5% of global mortality."( Adaikalakoteswari, A; Boachie, J; Samavat, J; Saravanan, P, 2020)
"Obesity is associated with systemic insulin resistance and cardiac hypertrophy with fibrosis."( Armendáriz-Borunda, J; Gutiérrez-Cuevas, J; Monroy-Ramírez, HC; Sandoval-Rodríguez, A; Santos-García, A; Vazquez-Del Mercado, M, 2021)
"Obesity is a major health problem worldwide."( Campana, M; Hakim, MP; Ignácio-Souza, LM; Le Stunff, H; Leal, RF; Magnan, C; Milanski, M; Miyamoto, JÉ; Portovedo, M; Reginato, A; Simino, LA; Torsoni, AS; Torsoni, MA, 2020)
"Aging and obesity are the most prominent risk factors for onset of atrial fibrillation (AF)."( Aonuma, K; Feng, D; Ieda, M; Li, S; Murakoshi, N; Okabe, Y; Qin, R; Tajiri, K; Xu, D; Yonebayashi, S; Yuan, Z, 2020)
"Obesity is associated with gut microbiome dysbiosis."( Chen, S; Cheng, H; Linhardt, RJ; Mao, G; Orfila, C; Wu, D; Xiao, H; Ye, X; Yu, C; Zhu, K, 2020)
"Overweight and obesity are major risk factors for diabetes, cardiovascular disease, and lung disease."( Greenway, FL; Kirwan, JP; Rebello, CJ, 2020)
"Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese."( Asghari, A; Umetani, M, 2020)
"Obesity is an asthma comorbidity associated with poor control, increased exacerbation risk and reduced response to inhaled and systemic corticosteroids."( Grasemann, H; Holguin, F, 2021)
"Obesity is a pathophysiological condition where excess free fatty acids (FFA) target and promote the dysfunctioning of insulin sensitive tissues and of pancreatic β cells."( Bandet, CL; Benomar, Y; Bourron, O; Guitton, J; Hajduch, E; Le Stunff, H; Mariko, ML; Tan-Chen, S, 2020)
"Introduction: Obesity is considered a serious public health problem."( Arias, I; Fang, L; Garavito, P; Mosquera-Heredia, MI; Navarro, É; Payares, F; Ruiz, M; Silvera-Redondo, C; Tuesca, R, 2020)
"Obesity is intimately associated with diet and dysbiosis of gut microorganisms but anxiolytics, widely used in treatment of psychiatric conditions, frequently result in weight gain and associated metabolic disorders."( Biswas, L; Craft, JA; Ibrahim, KS; Shu, X; Spencer, J, 2020)
"This implies obesity is associated with higher excretion rates."( Jain, RB, 2020)
"Maternal obesity is an emerging problem in the modern world."( Chen, CC; Hsu, TY; Huang, LT; Lai, YJ; Lin, IC; Lin, YJ; Liu, TY; Sheen, JM; Tain, YL; Tiao, MM; Tsai, CC; Yu, HR, 2020)
"Obesity is usually related to insulin resistance and glucose metabolism disorders."( Çelik, E; Güneş, H; Özmen, Ş; Temiz, F, 2020)
"Obesity is an important clinical entity, causing many public health issues."( de Sá, LBPC; Filho, DR; Ramirez, AVG, 2021)
"Obesity is known to be associated with risk and aggressiveness of cancer."( Cho, SY; Jung, Y; Kang, J; Kang, MW; Kwak, HJ; Lee, S; Park, J; Park, WY; Um, JY, 2020)
"Overweight and obesity are considered as chronic low-grade inflammation accompanied by imbalanced production of adipokines."( Jenko Pražnikar, Z; Jurdana, M; Petelin, A; Žiberna, L, 2020)
"Obesity is a significant risk factor for the development of types of cancer."( Gao, WQ; Li, Z; Liu, H; Wang, P; Wang, TQ; Xu, WC; Zhu, XY, 2020)
"Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health."( Domínguez-Riscart, J; González-Domínguez, Á; González-Domínguez, R; Lechuga-Sancho, AM; Mateos, RM; Visiedo-García, FM, 2020)
"Obesity is a chronic metabolic disease that increases the risk of developing health problems including respiratory disease, hypertension, hyperlipidemia, diabetes, and coronary heart disease."( Cheng, W; Fan, Z; Sun, J; Zhang, X, 2020)
"Obesity is a chronic low-grade inflammatory state associated with immune cell infiltration into the adipose tissue (AT)."( Anuradha, CV; Vidhya, R, 2020)
"Obesity is increasing in patients with type 2 diabetes."( Baillot-Rudoni, S; Bouillet, B; Brindisi, MC; Duvillard, L; Legris, P; Petit, JM; Rouland, A; Simoneau, I; Vergès, B, 2021)
"Obesity is one of the leading causes of preventable illness in the US."( Ferrario, CR, 2020)
"Obesity is characterized by chronic inflammation of low grade."( Cargnin-Cavalho, A; Costa, AB; da Rosa Turatti, C; de Farias, BX; de Souza Goldim, MP; Engel, NA; Fortunato, JJ; Jeremias, IC; Petronilho, F; Rezin, GT, 2020)
"Obesity is a major risk factor for diabetes and cardiovascular diseases such as hypertension, heart failure, and stroke."( Alorfi, NMN; Buckley, C; Dolan, S; Heathcote, HR; Lee, MD; MacDonald, M; McCarron, JG; Wilson, C; Zhang, X, 2020)
"Obesity is linked to a reduction in the control of hepatic glucose production, which is the primary mechanism related to fasting hyperglycemia and the development of type 2 diabetes mellitus (T2DM)."( Cintra, DE; da Silva, ASR; de Moura, LP; Morelli, AP; Pauli, JR; Pereira, RM; Peruca, GF; Rodrigues, KCDC; Ropelle, ER; Sant'Ana, MR; Simabuco, FM, 2020)
"Obesity is associated with development of severe CDI."( Andersen, H; Divanovic, S; Haslam, DB; Horrigan, O; Jose, S; Madan, R; Moreno-Fernandez, ME; Mukherjee, A; Setchell, KDR; Sharma, D; Zhang, W, 2021)
"Obesity is closely associated with insulin resistance (IR)."( Lungkaphin, A; Sutthasupha, P, 2020)
"Obesity is considered a risk factor for the development of non-alcoholic fatty liver disease (NAFLD)."( da Costa, CA; da Rocha, APM; Daleprane, JB; de Bem, GF; de Moura, RS; Ognibene, DT; Resende, AC; Santos, IB; Tavares, TB, 2020)
"Obesity is influenced by genetic and environmental factors."( Bimschleger, H; Chen, H; Cheng, R; Chitre, AS; Flagel, SB; Gao, J; Garcia Martinez, A; George, T; Gileta, AF; Han, W; Holl, K; Horvath, A; Hughson, A; Ishiwari, K; King, CP; Lamparelli, A; Martin, C; Meyer, P; Palmer, AA; Polesskaya, O; Richards, J; Robinson, TE; Solberg Woods, LC; St Pierre, CL; Tripi, JA; Versaggi, CL; Wang, T, 2020)
"Obesity is associated with an increased risk of metabolic abnormalities."( Egusa, Y; Fukumura, Y; Inomoto, T; Nishimuta, S; Nishinaka, T; Shimizu, K; Terada, T; Tomita, K; Yoshimura, M, 2021)
"Obesity is often associated with inflammation in adipose tissue (AT) with release of mediators of atherogenesis."( Akbari, O; Baronikian, L; Dieli-Conwright, C; Galle-Treger, L; Gonzalez, E; Hodis, HN; Jahani, PS; Lee, K; Mack, WJ; Mert, M; Sankaranarayanan, I; Sattler, FR, 2020)
"Obesity is linked with altered microbial short-chain fatty acids (SCFAs), which are a signature of gut dysbiosis and inflammation."( Alonso-Vale, MIC; Crisma, AR; Cruz, MM; Curi, R; Guima, SES; Hirabara, SM; Marcantonio Ferreira, C; Marino, E; Murata, GM; Payolla, TB; Pereira, JNB; Portovedo, M; Ribeiro, WR; Santos, MF; Sato, FT; Setubal, JC; Thomas, AM; Vinolo, MAR; Yap, YA, 2020)
"Obesity is associated with complex perturbations to whole-body and tissue iron homeostasis."( Ahn, C; Chenevert, TL; Foug, KL; Gillen, JB; Gioscia-Ryan, RA; Horowitz, JF; Ludzki, AC; Ryan, BJ; Schleh, MW, 2020)
"Obesity is a global epidemic associated with over 200 health complications and a significant risk of developing cardiovascular disease (CVD), partly by increasing classical risk factors such as lipid and glucose levels and blood pressure."( Jacob, S; Wilding, JPH, 2021)
"Obesity is a major worldwide public health issue that increases the risk to develop cardiovascular diseases, type-2 diabetes, and liver diseases."( Cormont, M; Estève, D; Gilleron, J; Ivanov, S; Jager, J; Meziat, C; Muller, C; Sulen, A; Tanti, JF, 2020)
"Maternal obesity is a risk factor for placental dysfunction, suggesting that factors within an obese environment may impair early placental development."( Dunk, CE; Lye, SJ; Rampersaud, AM; Renaud, SJ, 2020)
"Obesity is a worldwide life-threatening metabolic disorder, associated with various chronic diseases, including male infertility."( Ahmed, M; Alkafafy, M; Alotaibi, SS; El-Shazly, S; El-Shehawi, AM; Elseehy, MM; Farouk, S; Sayed, S, 2020)
"Diabetes and obesity are established risk factors for stroke."( Abidin, NE; Albitar, O; Aziz, ZA; Ghadzi, SMS; Harun, SN; Ibrahim, KA; Lee, KY; Loo, KW; Looi, I; Sidek, NN; Tangiisuran, B; Zainal, H, 2020)
"Obesity is a crucial public health problem and is rising globally."( Abd Hamid, HA; Ariaratnam, S; Ho, BK; Jane Ling, MY; Krishnapillai, AD; Mohd Yusoff, MF; Rodzlan Hasani, WS; Shariff Ghazali, S; Tohit, NM, 2020)
"Obesity is a global epidemic in developed countries accounting for many of the metabolic and cardiorespiratory morbidities that occur in adults."( Almeida Colombari, DS; Bassi, M; Colombari, E; Conde, S; Despotovic, N; Gauda, EB; Zoccal, DB, 2020)
"Obesity is considered an important factor that increases the risk of colorectal cancer (CRC)."( Gómez-Millán, J; Laborda-Illanes, A; Medina, JA; Ordóñez, R; Otero, A; Plaza-Andrade, I; Queipo-Ortuño, MI; Ramos-Molina, B; Sánchez-Alcoholado, L, 2020)
"Obesity is a major health problem worldwide, and non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty liver disease (NAFLD) are obesity-associated complications."( Chen, J; Chen, Y; Chen, Z; Fang, T; Hu, W; Huang, S, 2021)
"Obesity is characterized by disturbed adipocytokine expression and insulin resistance in adipocytes."( Chiang, CF; Hsieh, CH; Hung, YJ; Lee, CH; Liu, JS; Lu, GH; Shieh, YS; Su, SC, 2021)
"Obesity is a common disease over the world and is tightly associated with diabetes mellitus, cardiovascular and cancer disease."( Kim, SM; Yan, L; Zhang, S, 2020)
"Obesity is a major independent risk factor for increased morbidity and mortality upon infection with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), which is responsible for the current coronavirus disease pandemic (COVID-19)."( Beck, M; Gowdy, KM; Oestreich, KJ; Pal, A; Shaikh, SR, 2020)
"Obesity is a major health problem threatening humanity in medical, social and psychological dimensions."( Doganyigit, Z; Kaymak, E; Okan, A; Silici, S; Soylu, M; Yakan, B, 2020)
"Obesity is common comorbidity in patients with schizophrenia."( Huang, X; Huang, Y; Li, H; Li, J; Liu, Y; Mitchell, DT; Pan, Z; Wu, F; Wu, K; Xiong, D; Zhang, XY; Zhou, J, 2020)
"Obesity is associated with poorer executive functioning and reward sensitivity."( Donofry, SD; Erickson, KI; Jakicic, JM; Kang, C; Lesnovskaya, A; Peven, JC; Porter, A; Rogers, RJ; Stillman, CM; Watt, JC; Zhou, X, 2020)
"Obesity is linked to metabolism malfunction and concomitantly with altered mineral levels in the body."( Banach, W; Krajewska, N; Matuszak, O; Mongiałło, W; Muszyński, J; Nitschke, K; Skrypnik, D, 2020)
"Dietary obesity is regarded as a problem worldwide, and it has been revealed the strong linkage between obesity and allergic inflammation."( Ishii, N; Kagawa, Y; Kobayashi, S; Maruyama, T; Miyazaki, H; Owada, Y; Phung, HT; Takahashi, Y; Tayama, S, 2020)
"Obesity is a complex, multifactorial disorder."( Baron, M; Bonnefond, A; Froguel, P, 2020)
"Obesity is associated with cardiovascular (CV) risk factors and diseases."( America, YGCJ; de Boer, RA; Hazebroek, EJ; Hemels, MEW; Rienstra, M; van Veldhuisen, DJ; van Veldhuisen, SL; van Woerden, G, 2021)
"Obesity is associated with impaired primary and secondary immune responses to influenza infection, with T cells playing a critical role."( Alwarawrah, Y; Beck, MA; Eisner, W; Green, WD; Hale, LP; Kiernan, K; MacIver, NJ; Nichols, AG; Warren, J, 2020)
"Obesity is a multifactorial disease."( Essenmacher, L; Griffin, LE; Iglesias-Carres, L; Neilson, AP; Racine, KC; Smith, SM; Tessem, JS, 2021)
"Obesity is one of major risk factors increasing chronic diseases including type II diabetes, cardiovascular diseases, and hypertension."( Chatree, S; Churintaraphan, M; Keadkraichaiwat, I; Maikaew, P; Pongwattanapakin, K; Sitticharoon, C; Sripong, C; Sririwichitchai, R; Tapechum, S, 2021)
"Obesity is associated with altered glycine metabolism in humans."( Edwards, AK; McKnight, SM; Satterfield, MC; Simmons, RM; Wu, G, 2020)
"Adults with obesity are at an increased risk of incident hypertension."( Baynard, T; Bunsawat, K; Clifford, PS; Fadel, PJ; Fernhall, BO; Grigoriadis, G; Kilianek, MM; Lefferts, EC; Wee, SO, 2021)
"Obesity is associated with underlying inflammation due to increased tissue macrophage infiltration, and recent evidence shows that inflammation can drive obesity, creating a feed forward mechanism."( Bokshi, B; Chan, YL; Chen, H; Gregory Oliver, B; Haghi, M; Komalla, V; Li, G; Sheikholeslami, B; Ung, A, 2020)
"Obesity is a health problem associated with many metabolic disorders."( Chen, PD; Huang, CC; Lee, PC; Lin, MT; Wu, JM; Yang, PJ; Yeh, CL; Yeh, SL, 2020)
"Obesity is a low-grade inflammatory disease that is getting increasingly common among adults and children and causes different complications."( Altan, F; Tokgöz, HB, 2020)
"Obesity is of complex origin, involving genetic and neurobehavioral factors."( Beyer, F; Loeffler, M; Scholz, M; Stumvoll, M; Villringer, A; Wirkner, K; Witte, AV; Zhang, R, 2021)
"Obesity is classically associated with low serum total and free 25(OH)D."( Astier, J; Bonnet, L; Couturier, C; Defoort, C; Karkeni, E; Landrier, JF; Mounien, L; Svilar, L; Tourniaire, F, 2021)
"Aging, diabetes and obesity are characterized by diminished taste and sweet perception."( Battelino, S; Battelino, T; DeVries, JH; Janez, A; Jensterle, M; Yildiz, B, 2021)
"Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it."( Govitrapong, P; Tocharus, C; Tocharus, J; Yawoot, N, 2021)
"Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut microbiota."( Fu, Z; Hu, L; Ma, L; Ni, L; Ni, Y; Tu, W; Wang, Z; Zhao, Y; Zheng, A; Zheng, L; Zhuge, F, 2020)
"Obesity is a chronic, relapsing metabolic disease, linked to a number of health risks and serious complications."( Fitch, A; Ingersoll, AB, 2021)
"Obesity is closely linked with type 2 diabetes and the effective therapies on obesity-associated diabetes are under development."( Chan, PC; Hsieh, PS; Liao, MT; Lu, CH; Tian, YF, 2021)
"We found that obesity is associated with multiple CVDs, but can only occur in unhealthy metabolic patients."( Ashrafizadeh, M; Farkhondeh, T; Llorens, S; Pourbagher-Shahri, AM; Samarghandian, S; Shakibaei, M; Talebi, M, 2020)
"A major driver of obesity is the increasing palatability of processed foods."( Gendelis, S; Inbar, D; Inbar, K; Kupchik, YM; Mesner, S, 2020)
"Obesity is a major public health with increasing numbers of obese individuals are at risk for kidney disease."( Chaiwatanarat, T; Eiam-Ong, S; Katavetin, P; Kittiskulnam, P; Praditpornsilpa, K; Tiskajornsiri, K, 2020)
"Class 1 obesity is associated with enhanced platelet activation in response to AA in patients on dual antiplatelet therapy."( Eichelberger, B; Gremmel, T; Kopp, CW; Lee, S; Panzer, S, 2021)
"Obesity is an important public health issue that has been on the rise over the last decades."( Pellitero, S; Perez-Montes DE Oca, A; Puig-Domingo, M, 2021)
"Obesity is considered a low-grade systemic inflammation, partly linked to leaky gut."( Abdel-Mohsen, M; Adnan, D; Bishehsari, F; Engen, PA; Giron, LB; Green, SJ; Keshavarzian, A; Naqib, A; Sarrafi, S; Shaikh, M; Wilber, S, 2021)
"Overweight/obesity is defined as age-, sex-specific BMI z-score ≥ 85th percentile; abdominal obesity is defined as age-, sex-specific waist circumference ≥90th percentile."( Geiger, SD; Qian, Z; Vaughn, MG; Yao, P, 2021)
"Obesity is known to be associated with an increased risk of uterine atony and postpartum haemorrhage."( Balki, M; Carvalho, JCA; Downey, K; Maxwell, C; Peska, E; Ye, XY, 2021)
"Obesity is an important health issue nowadays."( Chou, RF; Ho, CT; Nagabhushanam, K; Pan, MH; Tung, YC, 2020)
"Obesity is one of the most prevalent health conditions in humans and companion animals globally."( Raffan, E; Wallis, N, 2020)
"Obesity is associated with changes in adipose tissue extracellular matrix (ECM), but the impact of these changes on adipose tissue mechanics and their role in metabolic disease is poorly defined."( Baker, NA; Flesher, CG; Green, PF; Lumeng, CN; Muhammad, LN; Neeley, CK; O'Rourke, RW; Varban, OA; Wenderott, JK; Yeh, C, 2020)
"Obesity is a widely spread disease and a crucial risk factor for malign disorders, including breast cancer of women in the postmenopause."( Bähr, I; Glaß, M; Jung, JS; Kielstein, H; Mattheis, L; Oswald, J; Quandt, D; Rauße, H; Spielmann, J, 2020)
"Human obesity is characterized by increased plasma leptin levels, which have been related with different obesity-associated complications, such as chronic inflammatory state (risk factor for diabetes, cardiovascular and autoimmune diseases), as well as infertility and different types of cancer."( Jiménez-Cortegana, C; Millán-Linares, MC; Montserrat-de la Paz, S; Muriana, FJG; Pérez-Pérez, A; Sánchez-Margalet, V; Vilariño-García, T, 2021)
"Obesity is an important independent risk factor for type 2 diabetes, cardiovascular diseases, and many other chronic diseases."( Chen, S; Chen, SY; Cui, XB; Edwards, GL; Fei, J, 2021)
"Obesity is a global problem and the most common metabolic disorder leading to many associated diseases, such as arterial hypertension, ischemic heart disease, type 2 diabetes, certain types of cancer, impaired lipid and uric acid metabolism."( Koksharova, E; Mayorov, A; Menshikov, M; Parfyonova, Y; Shestakova, M; Sklyanik, I; Sorkina, E; Stafeev, I; Tumanyan, T, 2021)
"Obesity is growing at an alarming rate, which is characterized by increased adipose tissue."( Arockiaraj, J; Arshad, A; Guru, A; Issac, PK; Saraswathi, NT; Velayutham, M, 2021)
"Elevated weight and obesity are common in young first-time allogeneic United States blood donors, with fewer donors having elevated total cholesterol or anaemia."( Bravo, MD; Hughes, JA; Kamel, H; Townsend, M, 2021)
"Obesity is characterized by leptin resistance, which contributes to increased risk of all-cause mortality."( Allison, DJ; Bullock, A; Heisz, JJ; Nicholson, E, 2021)
"Obesity is mainly ascribed to higher lipid accumulation in the body."( Das, M; Kumar, GS, 2021)
"Obesity is associated with metabolic dysregulation characterized by insulin resistance and glucose intolerance."( Braud, L; Derumeaux, G; Foresti, R; Manin, S; Motterlini, R; Pini, M; Stec, DE; Stec, DF, 2021)
"Interestingly, obesity is further accelerated in castrated mice fed a high-fat diet, suggesting hypogonadism increases susceptibility to obesogenesis when dietary consumption of fat is elevated."( Rodeheffer, MS; Sebo, ZL, 2021)
"Obesity is associated with increased sympathetic nervous system activation, possibly contributing to higher cardiovascular risk."( Balis, P; Chomova, M; Torok, J; Ulicna, O; Valovic, P; Zemancikova, A, 2020)
"Obesity is a global public health problem and a risk factor for several metabolic disorders as well as cancer."( Aizawa, T; Ito, M; Kominami, Y; Nakao, T; Ohara, K; Satone, H; Ueno, T; Ushio, H; Yuan, X, 2020)
"Obesity is a chronic low-grade inflammatory state leading to organ damage with increased risk of common diseases including cardiovascular and metabolic disease, non-alcoholic fatty liver disease, osteoarthritis and some cancers."( Brown, L; Ghattamaneni, NKR, 2021)
"However, obesity is also associated with sternal wound infection (SWI) which is a severe complication of CABG despite advances in surgery and in infection prevention and control."( Bajolet, O; Brunet, A; Lefebvre, A; N'Guyen, Y; Poncet, A; Robbins, A; Rubin, S; Ruggieri, VG; Saade, Y, 2020)
"Obesity is becoming pandemic and is associated with impaired reproductive potential."( Anelli, GM; Cetin, I; Lisso, F; Mandò, C; Marzorati, A; Novielli, C; Oneta, M; Parrilla, B; Savasi, VM, 2020)
"Obesity is a significant global health and socio-economic challenge, and considered an important risk factor for poor health outcomes including male reproductive dysfunction and infertility."( Almaghrawi, W; Henkel, R; Leisegang, K, 2021)
"Obesity is a complex disease with many causes, including a possible role for environmental chemicals."( Axelstad, M; Chalmel, F; Evrard, B; Lardenois, A; Ramhøj, L; Ramskov Tetzlaff, CN; Svingen, T; Taxvig, C, 2021)
"Obesity is a global health threat and a risk factor for several metabolic conditions."( Arellanes-Licea, EDC; Carmona-Castro, A; Díaz-Muñoz, M; Miranda-Anaya, M; Pérez-Mendoza, M, 2021)
"Obesity is closely associated with non-alcoholic fatty liver disease (NAFLD), and elevated serum palmitate is the link between obesity and excessive hepatic lipid accumulation."( Cheng, Y; Feng, Y; Han, L; Li, T; Liu, X; Tan, H; Wang, L; Zhao, N, 2021)
"Obesity is a chronic disease derived from disequilibrium between energy intake and energy expenditure and evolving as a challenging epidemiological disease in the 21st century."( Li, H; Li, L; Wang, C, 2021)
"Obesity is a risk factor for NMBA anaphylaxis, the risk increasing with BMI grade."( Clarke, RC; Day, C; Goddard, CE; Middleditch, A; Platt, PR; Sadleir, PHM; Weightman, W, 2021)
"Thyroid disease and obesity are widespread clinical conditions in the population."( Cannarella, R; De Geronimo, V; La Vignera, S, 2021)
"Obesity is marked by the buildup of fat in adipose tissue that increases body weight and the risk of many associated health problems, including diabetes and cardiovascular disease."( Gardner, QA; Khan, ZN; Lian, JB; Shakoori, AR; Stein, GS; Stein, JL; Tariq, M; Tassaduq, R; Toor, RH; Waheed-Uz-Zaman, W, 2020)
"Obesity is associated with higher extracellular fluid (ECF) compared to intracellular fluid (ICF) volume and this dysregulation is associated with hypertension and abdominal obesity, associated with metabolic syndrome."( Aaseth, J; Bjørke-Monsen, AL; Mikalsen, SM; Ueland, GÅ; Whist, JE, 2021)
"Obesity is increasing worldwide."( Caputo, EL; Delpino, FM; Figueiredo, LM; Gigante, DP; Mintem, GC, 2021)
"Obesity is prevalent in type 1 diabetes and diabetes complications are not only related to glucose control."( Ajjan, RA; Birch, R; Campbell, M; Helliwell, R; Kietsiriroje, N; Pearson, SM; Warnes, H, 2021)
"Obesity is associated with increased serum leptin level, endothelial dysfunction and angiogenesis."( Bogdański, P; Pelczyńska, M; Skrypnik, D; Skrypnik, K; Sobieska, M; Suliburska, J; Tinkov, AA, 2021)
"Worldwide obesity is a public health concern that has reached pandemic levels."( Avagliano, C; Berni Canani, R; Calignano, A; Coppola, S, 2021)
"Obesity is common in heart failure with preserved ejection fraction (HFpEF)."( Butler, J; Elkholey, K; Papadimitriou, L; Stavrakis, S; Thadani, U, 2021)
"Obesity is now a worldwide disease and is mainly attributable to increased body fat deposition."( Du, Y; Hao, L; Liu, L; Luo, G; Tan, Z; Wang, D; Wang, N; Xie, H; Yang, X; Zhou, J, 2021)
"Obesity is associated with an increased risk of psoriasis."( Arlegui, H; Assan, F; Bachelez, H; Beneton, N; Beylot-Barry, M; Chosidow, O; Dupuy, A; Giboin, C; Joly, P; Jullien, D; Mahé, E; Paul, C; Richard, MA; Sbidian, E; Tubach, F; Viguier, M, 2021)
"Obesity is defined as an abnormal accumulation of adipose tissue, which is one of the major metabolic organs that regulate energy homeostasis."( Han, J; Im, H; Im, S; Kim, K; Lee, YH; Park, JH, 2021)
"Obesity is a complex endocrine disease, mainly caused by environmental, behavioral and biological factors."( Abawi, O; van den Akker, ELT; van der Valk, ES; van der Voorn, B; van Rossum, EFC; Welling, MS, 2021)
"The prevalence of obesity is increasing globally and is associated with many metabolic disorders, such as type 2 diabetes and cardiovascular diseases."( Chu, Y; Gu, P; Hui, X; Lin, S; Liu, X; Loomes, K; Mao, L; Nie, T; Tang, S; Wu, D; Xu, Y; Zhang, Y; Zhao, S; Zhao, X, 2021)
"Obesity is a global health challenge with few pharmacologic options."( Batterham, RL; Calanna, S; Davies, M; Kushner, RF; Lingvay, I; McGowan, BM; Rosenstock, J; Tran, MTD; Van Gaal, LF; Wadden, TA; Wharton, S; Wilding, JPH; Yokote, K; Zeuthen, N, 2021)
"Obesity is one of the main risk factors for the development of non-communicable diseases, which are now the leading cause of death worldwide."( AlAmri, S; AlFaiz, A; Alghamdi, S; Alhabeeb, H; AlJohani, N; Alotaibi, K; Alotaibi, N; AlRajhi, S; AlShahrani, D; Alsuhail, A; Kutbi, E, 2021)
"Nowadays, obesity is one of the great nutritional problems facing public health."( Andueza, N; Giner, RM; Portillo, MP, 2021)
"Obesity is a correctable factor for uncontrolled bronchial asthma."( Hur, J; Kang, JY; Kim, YK; Lee, HY; Lee, SY, 2021)
"Obesity is a major risk factor for adverse outcomes in breast cancer; however, the underlying molecular mechanisms have not been elucidated."( Ackerman, SE; Annis, MG; Carroll, TS; Ceballos, V; Cohen, P; Dannenberg, AJ; Dykstra, CB; Gelfer, RG; Hejazi, A; Huang, X; Jiang, CS; Kazak, L; Kramer, DJ; Luo, JD; Maganti, AV; Maguire, OA; Marchildon, F; Mirmira, RG; Rahbani, JF; Rosas-Villegas, A; Samborska, B; Siegel, PM; Szwed, SK; Tersey, SA; Turner, LE, 2021)
"Obesity is an important comorbidity affecting outcomes after total joint arthroplasty."( Dunbar, M; Dusik, C; Lethbridge, L; Richardson, G, 2021)
"Obesity is associated with increased risk of multiple sclerosis (MS); however, the underlying mechanisms remain unclear."( Baranzini, SE; Butler-Laporte, G; Davey Smith, G; Harroud, A; Manousaki, D; Mitchell, RE; Richards, JB, 2021)
"Obesity is critically associated with the development of insulin resistance and related cardiovascular and kidney diseases."( Aranda, P; Galisteo, M; Kapravelou, G; Lopez Trinidad, LM; Lopez-Jurado, M; Martinez, R; Porres, JM, 2021)
"Prolonged obesity is associated with fundamental changes in the integrative control of energy balance, including the development of selective leptin resistance, which is thought to contribute to obesity-associated hypertension, and adaptation of resting metabolic rate (RMR) when excess weight is reduced."( Grobe, JL; Kwitek, AE; Morselli, LL; Oliveira, V; Sigmund, CD, 2021)
"Obesity is a risk factor for developing several cancers."( Brown, JC; Gilmore, LA; Ochoa, AC; Sanchez-Pino, MD, 2021)
"Obesity is a global health concern associated with the dysbiosis of intestinal microbial composition."( Abdulrahman, AO; Alzubaidi, MY; Khan, JA; Khan, MI; Nadeem, MS; Rather, IA, 2021)
"Obesity is a major risk factor for cardiometabolic diseases."( Bayrak, CS; Carobbio, S; Chami, N; den Hoed, M; Huang, LO; Itan, Y; Kilpeläinen, TO; Loos, RJF; Mandrup, S; Mazzaferro, E; Preuss, M; Rauch, A; Schick, UM; Vidal-Puig, A; Wang, Z; Yang, N, 2021)
"In adults, obesity is often associated with salt-sensitive hypertension."( Fujita, T; Kawarazaki, W, 2021)
"Overweight and obesity are undoubtable risk factors for type 2 diabetes and cardiovascular diseases and significantly contribute to the global morbi-mortality."( Bousquet, P; Fellmann, L; Monassier, L; Niederhoffer, N; Regnard, P; Weiss, M, 2021)
"Obesity is defined as abnormal or excessive fat accumulation that presents a risk to health."( Grammatikopoulou, MG; Hatziagorou, E; Kontouli, K; Spiliotis, BE; Tsanakas, J; Tsiroukidou, K; Tzimos, C; Vamvakis, A, 2021)
"Obesity is one of the most incident and concerning disease worldwide."( Baselga-Escudero, L; Caimari, A; Del Bas, JM; Hernandez-Baixauli, J; Mulero, M; Palacios-Jordan, H; Puigbò, P; Ripoll, VJR; Torrell, H, 2021)
"Obesity is rapidly dispersing all around the world and is closely associated with a high risk of metabolic diseases such as insulin resistance, dyslipidemia, and nonalcoholic fatty liver disease (NAFLD), leading to carcinogenesis, especially hepatocellular carcinoma (HCC)."( Rajesh, Y; Sarkar, D, 2021)
"Obesity is associated with the development of comorbid conditions and psychological disorders."( Almuhtadi, YA; Alsharif, FJ, 2021)
"Obesity is an increasingly concerning global health issue, which is accompanied by disruption of glucose and lipid metabolisms."( Guo, XX; Qiu, J; Wang, Y; Xu, DX; Zeng, Z, 2021)
"Obesity is one of the most critical risk factors for diabetes mellitus and plays a significant role in diabetic nephropathy (DN)."( Cui, J; Guo, G; Luo, Y; Wan, H; Xie, S; Zhou, G, 2021)
"Obesity is considered a serious global health issue."( El-Sayed, EM; Ibrahim, KS, 2021)
"Obesity is a complex disease associated with a high risk of comorbidities."( Achiam, MP; Bach, A; Bouvier, M; Buijink, JA; Cox, H; Diep, TA; Frimurer, TM; Grunddal, KV; Hartmann, B; Hjorth, SA; Holst, B; Jepsen, SL; Jin, C; Liu, L; Mende, F; Petersen, N; Skov, LJ; Strandby, RB; Sørensen, LME; Tough, IR, 2021)
"Hyperglycemia and obesity are associated with reduced cerebral blood flow and neurovascular uncoupling which may lead to behavioral deficits."( Hövener, JB; Huber, G; Huber, L; Jurk, D; Matschl, U; Ogrodnik, M; Peschke, E; Raasch, W; Schwaninger, M; Stölting, I; Wenzel, J; Will, O, 2021)
"Obesity is a worldwide concern as it leads to adverse effects on human health."( Go, YH; Lau, LS; Ng, CF; Yiew, TH, 2021)
"Obesity is a chronic low-grade inflammation state associated with several diseases."( Cernadas, JR; Dias de Castro, E; Paredes, S; Pinhão, S; Ribeiro, L, 2021)
"Obesity is a predictor of incident CKD and progression to kidney failure."( Campbell, KL; Conley, MM; Johnson, DW; Kelly, JT; MacLaughlin, HL; McFarlane, CM, 2021)
"Obesity is frequently associated with a chronic low-grade inflammation in the adipose tissue (AT) and impaired glucose homeostasis."( Arndt, L; Bechmann, I; Braune, J; Brinker, G; Froeba, J; Gericke, M; Hobusch, C; Lindhorst, A, 2021)
"Obesity is characterized by low-grade chronic inflammation, which underlies insulin resistance and non-alcoholic fatty liver disease (NAFLD)."( Cai, S; Ding, C; Jin, S; Li, D; Liang, X; Tang, Y; Xu, L; Zhu, Y, 2021)
"Sustained obesity is characterized by a chronic and unsolved inflammation of adipose tissue, which leads to a greater expression of proinflammatory adipokines, excessive lipid storage and adipogenesis."( Bava, I; Bosco, F; Cardamone, A; Carresi, C; Coppoletta, AR; Gliozzi, M; Guarnieri, L; Macrì, R; Maiuolo, J; Mollace, R; Mollace, V; Musolino, V; Nucera, S; Palma, E; Ragusa, M; Ruga, S; Scarano, F; Scicchitano, M; Zito, MC, 2021)
"Obesity is a globally increasing health problem, entailing diverse comorbidities such as infectious diseases."( Deinhardt-Emmer, S; Hornung, F; Löffler, B; Loskill, P; Rogal, J, 2021)
"Obesity is a common disease of developing countries, including Pakistan."( Akhter, N; Akram, M; Asif, HM; Ayaz, S; Iqbal, A; Khurram, H; Mahmood, A; Rashid, A; Riazurrehman, M, 2020)
"Obesity is a global epidemic that causes morbidity and impaired quality of life."( Ben-Zvi, D; Botta, J; Chan, LF; Chunilal, V; Degtjarik, O; Fierro, F; Gill, AK; Israeli, H; McCormick, PJ; Niv, MY; Peleg, Y; Prabahar, V; Roth, NJ; Shalev-Benami, M, 2021)
"Obesity is characterized by low-grade inflammation, which predisposes individuals to metabolic syndrome via unknown mechanisms."( Djouder, N; Ferre, A; Garrido, A; Perna, C; Teijeiro, A, 2021)
"Obesity is a well-known public health issue around the world."( Lin, MT; Su, LH; Yeh, CL; Yeh, SL, 2021)
"Obesity is often introduced as one of the metabolic disorders caused by imbalance between energy consumption and metabolisable energy intake."( Ghazalian, F; Khodayar, MJ; Khorsandi, L; Raesi Vanani, A; Shushizadeh, MR; Zalaqi, Z, 2022)
"Obesity is highly prevalent worldwide, including among people with chronic kidney disease (CKD)."( Harb, H; Nolan, BJ; Song, R; Sumithran, P, 2021)
"Obesity is a widespread disease that is associated with numerous and serious comorbidities."( Calogero, AE; Cannarella, R; Cimino, L; Compagnone, M; Condorelli, RA; La Vignera, S; Mongioì, LM, 2021)
"Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance."( Castillo-Fernandez, J; Galvão, A; Kelsey, G; Wołodko, K, 2021)
"Although adult obesity is attributable to occupational factors, few reports are available on Malaysian health-care workers' obesity and whether different health-care job categories are related to workers' obesity."( Daud, A; Jusoh, N; Kunyahamu, MS, 2021)
"Obesity is a chronic, complex pathology associated with a risk of developing secondary pathologies, including cardiovascular diseases, cancer, type 2 diabetes (T2DM) and musculoskeletal disorders."( Barbacini, P; Belloli, S; Canu, T; Capitanio, D; Chaabane, L; Esposito, A; Gelfi, C; Malosio, ML; Moresco, RM; Moriggi, M; Murtaj, V; Penati, S; Torretta, E, 2021)
"Obesity is a major public health problem worldwide."( Bernardini, R; Burgaletto, C; Cantarella, G; Cortinovis, M; Di Mauro, R; Frara, S; Giustina, A; Munafò, A; Perico, N; Remuzzi, G, 2021)
"Obesity is a global health problem characterized by excessive fat deposition in adipose tissues and can be managed by targeting pancreatic lipase (PL) activity."( Akeghware, O; Anigboro, AA; Avwioroko, OJ; Tonukari, NJ, 2021)
"Obesity is defined as increased adiposity, which leads to metabolic disease."( Chávaro-Ortiz, LI; Frigolet, ME; Gutiérrez-Aguilar, R; Rico-Hidalgo, M; Tapia, BD, 2022)
"Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D)."( Bermano, G; Limongi, AR; Martelli, G; Padula, MC; Radice, RP; Viviano, E, 2021)
"Obesity is caused by an imbalance between food intake and energy expenditure (EE)."( Bensellam, M; Enriquez, R; Gao, H; Gao, Z; Gou, L; Haigh, JJ; Herzog, H; Hughes, W; Ip, CK; Lau, J; Laybutt, DR; Lee, K; Loh, K; Nobis, M; Shi, YC; Timpson, P; Wang, QP; Wu, Q; Xia, Z; Yan, C; Zeng, T; Zhang, L, 2021)
"Obesity is a serious health issue as it is a social burden and the main risk factor for other metabolic diseases."( Li, X; Liu, J; Liu, M; Wang, L; Wu, Y; Yin, F; Yin, L, 2021)
"Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases."( Sun, M; Zhang, X, 2021)
"Obesity is accompanied by adipose tissue inflammation that subsequently reduces thermogenic potential in brown and beige (brown-like) adipocytes."( Jo, SM; Kang, I; Kim, DS; Lee, M; Lee, Y; Seo, SH; Truong, TTM; Zhang, G, 2021)
"Obesity is a known risk factor for colorectal cancer (CRC) and adenoma."( Joshu, CE; Lu, J; Marrone, MT; Platz, EA; Visvanathan, K, 2021)
"Obesity is a rising concern globally."( AbRashid, N; Apalasamy, YD; Awang, H; Kamarulzaman, ND; Lih Yoong, T; Mansor, N, 2021)
"Obesity is associated with increased cardiovascular risk; however, the potential role of dysregulations in the adipose tissue (AT) metabolome is unknown."( Akawi, N; Akbar, N; Akoumianakis, I; Antoniades, C; Antonopoulos, AS; Badi, I; Channon, KM; Checa, A; Choudhury, R; Chuaiphichai, S; Daskalaki, E; Kondo, H; Kotanidis, CP; Lee, K; Lundgren, J; Neubauer, S; Polkinghorne, M; Torekov, SS; Wheelock, CE; Yesilyurt, D, 2021)
"Obesity is a driving factor in the onset of metabolic disorders."( Chong, CW; Chua, KH; Kuppusamy, UR; Nallappan, D; Ong, KC; Palanisamy, UD; Teh, CSJ, 2021)
"Obesity is associated with sarcopenia in older adults, and weight loss can lead to further muscle mass loss."( Espinoza, SE; Ganapathy, V; Lee, JL; MacCarthy, D; Musi, N; Pascucci, C; Volpi, E; Wang, CP, 2021)
"Obesity is a chronic, non-transmissible and multifactorial disease commonly associated with systemic inflammation and damage to health."( Anaruma, CP; Cintra, DE; da Cruz Rodrigues, KC; da Silva, ASR; de Campos, TDP; de Melo, DG; de Moura, LP; Dos Santos Canciglieri, R; Pauli, JR; Pereira, RM; Ropelle, ER, 2021)
"Obesity is closely associated with maintaining mitochondrial homeostasis, and mitochondrial dysfunction can lead to systemic lipid metabolism disorders."( Hou, X; Liu, H; Liu, J; Liu, M; Xie, J; Yan, J; Zhao, B, 2021)
"Obesity is often accompanied by chronic low-grade inflammation, which aggravates the disorder of lipid metabolism and leads to insulin resistance (IR)."( Dong, J; Qiu, Z; Wang, B; Xu, J; Yao, F, 2021)
"People with obesity are often dyslipidemic and prescribed statins to prevent cardiovascular events."( Alfulaij, N; Berry, MJ; Hashimoto, AC; Maunakea, AK; Peres, R; Seale, LA; Sultana, R; Torres, DJ; Watanabe, LM, 2021)
"Obesity is a growing worldwide problem, especially in developed countries."( Juchnicka, I; Kuźmicki, M; Szamatowicz, J, 2021)
"Postmenopausal obesity is associated with estrogen production from adipose tissue, while abnormal cell growth is triggered by insulin-like growth factor 1 (IGF-1) and insulin."( Faruk, M; Padang, OS; Pieter Junior, J; Prihantono, P; Sampepajung, E; Septiman, S; Soraya, GV; Syamsu, SA, 2021)
"Obesity is commonly reported in COVID-19 patients and is associated with poorer outcomes."( Binquet, C; Blot, M; Bourredjem, A; Nguyen, M; Piroth, L, 2021)
"Obesity is a risk factor for periodontal disease (PD)."( Kato, T; Miura, N; Nakanishi, Y; Ohno, H; Okuda, S; Sato, K; Tsuzuno, T; Yamada-Hara, M; Yamazaki, K; Yokoji-Takeuchi, M, 2021)
"Obesity is a major public health issue globally, with pregnant women often affected by the condition."( Fairweather-Tait, S; Froessler, B; Hodyl, NA; Wawer, AA, 2021)
"Obesity is a global health issue for which no major effective treatments have been well established."( Baqueiro, MDN; Lisboa, PC; Milanski, M; Panzarin, C; Reginato, A; Siqueira, BP; Torsoni, AS; Veras, ACC, 2021)
"Obesity is a serious health complication in almost every corner of the world."( Bhardwaj, M; Chahal, J; Dalal, S; Kataria, SK; Kumar, A; Sharma, K; Vashishth, D; Yadav, P, 2021)
"Obesity is recognized as a risk for the development of chronic kidney disease."( Cherngwelling, R; Lungkaphin, A; Pengrattanachot, N; Phengpol, N; Promsan, S; Sutthasupha, P; Swe, MT; Thongnak, L, 2021)
"Obesity is strongly related to leptin resistance that refers to the state in which leptin fails to inhibit appetite, enhance energy expenditure and regulate glycolipid metabolism, whereas decreasing leptin resistance is important for obesity treatment."( Peng, J; Wang, X; Yin, L, 2021)
"Obesity is an issue of great concern to people all over the world."( Duan, Y; Guo, Q; Li, F; Li, T; Song, B; Xiao, H; Zheng, C; Zheng, J, 2021)
"Obesity is an important risk factor for severe acute pancreatitis."( Ding, Z; Guo, X; Sheng, L; Xu, T, 2022)
"Obesity is increasing rapidly across the globe."( Abdel-Gabbar, M; Anwar, S; El-Zanaty, AM; Esmail, M; Kandeil, M, 2021)
"Obesity is a risk factor for development of metabolic diseases and cognitive decline; therefore, obesity prevention is of paramount importance."( Kim, J; Lee, H; Mikami, T; Park, J; Suidasari, S; Yaicharoen, P; Yamauchi, K; Yokozawa, M, 2021)
"Obesity is a growing health problem worldwide."( Antoniadis, CP; Barber, E; Begg, DP; Bennett, G; Cameron-Smith, D; Jois, M; Lambrou, M; Mitchell, CS; Premaratna, SD; Stahl, LA; Weisinger, RS; Woods, SC, 2021)
"Obesity is one of the most important risk factors for acute pancreatitis."( Cheng, J; He, M; Lv, X; Ren, Y; Wu, Y; Xian, Y, 2021)
"Obesity is the second most common cause of preventable morbidity worldwide."( Almgren, H; Clohesy, R; Duehlmeyer, L; Parsons, N; Steward, T, 2022)
"Obesity is increasing rapidly worldwide and is accompanied by many complications, including impaired muscle regeneration."( Du, M; Mao, X; Niu, W; Wang, B; Wang, H, 2021)
"Obesity is known as metabolic syndrome and it affects many tissues including adipose tissue, liver, and central nervous system (CVS)."( An, HJ; Cominguez, DC; Jin, JS; Kim, HJ; Kim, SY; Koh, DJ; Lim, YW; Park, YB; Park, YJ, 2021)
"Obesity is also linked with complications and mortality, irrespective of the therapy used, affecting clinical outcomes."( Castiñeiras, J; de la Cruz-Merino, L; Jiménez-Cortegana, C; López-Saavedra, A; Pérez-Pérez, A; Sánchez-Jiménez, F; Sánchez-Margalet, V; Virizuela-Echaburu, JA, 2021)
"Obesity is among the most alarming health concerns, impacting public health and causing a socioeconomic challenge, especially in developing countries like Brazil, where approximately one quart of the population presents obesity."( Navarro, AM; Seale, LA; Watanabe, LM, 2021)
"Obesity is a global health problem that is associated with adverse consequences such as the development of metabolic disorders, including cardiovascular disease, neurodegenerative disorders, and type 2 diabetes."( Hong, J; Kim, KW; Yang, DJ, 2021)
"Obesity is one of the foremost risk factors in coronavirus infection resulting in severe illness and mortality as the pandemic progresses."( Devender, M; Gertler, A; Maurya, R; Namdeo, M; Sebastian, P, 2021)
"Obesity is a major public health and economic problem of global significance."( Chu, X; Liu, H; Liu, M; Lu, J; Pan, D; Shi, X; Wu, J; Xia, B; Xie, B; Zhu, M, 2021)
"Obesity is becoming a major global health issue and is mainly induced by the accumulation of adipose tissues mediated by adipogenesis, which is reported to be regulated by peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα)."( Hao, T; Jiang, H; Lv, X; Qiu, J; Tan, Y; Zhang, H, 2021)
"Obesity is a global epidemic disease that is closely associated with various health problems as Diabetes mellitus, cardiovascular, and metabolic disorders."( Albrahim, T; Alonazi, MA, 2021)
"Obesity is a growing global epidemic that stems from the increasing availability of highly-palatable foods and the consequent enhanced calorie consumption."( Gendelis, S; Inbar, D; Kupchik, YM, 2021)
"Obesity is one of the world's largest health problems, and 3-N-butylphthalide (NBP), a bioactive compound in celery, has been used in dieting and weight management programs."( Harn, HJ; Lin, SZ; Lin, WJ; Liu, SP; Lu, KY; Primus Dass, KT, 2021)
"Also, obesity is more easily to occur in T2DM."( Chen, Y; Ma, B; Qu, S; Sheng, C; Wang, X; Yang, P; Zha, X, 2021)
"Obesity is a common disease worldwide and there is an urgent need for strategies to preventing obesity."( Chen, SW; Gong, PM; Guo, MJ; Han, X; Jiao, YH; Liang, C; Lyu, LZ; Meng, L; Niu, HY; Wu, YF; Zhang, LW; Zhou, XH, 2021)
"Obesity is frequently a comorbidity of type 2 diabetes."( Ben Nasr, M; Berra, C; Bolla, AM; D'Addio, F; Fiorina, P; Ippolito, E; Lazzaroni, E; Loretelli, C; Lunati, ME; Montefusco, L; Pastore, I; Plebani, L; Rossi, A; Vallone, L; Zuccotti, GV, 2021)
"Obesity is a main contributing factor for the development of glucose intolerance and type 2 diabetes mellitus (T2D)."( Li, D; Shi, Q; Wang, C; Wang, Q; Yang, H; Yin, Z; Yu, S; Zhong, H, 2021)
"Obesity is frequently associated with cerebrovascular dysfunction; however, the underlying mechanism remains less well understood."( Shen, Q; Zhang, G, 2021)
"Obesity is a significant problem worldwide and affects outcomes from sepsis."( Davis, X; Kaplan, J; Lahni, P; Li, C; Stuck, J; Williamson, L, 2021)
"Obesity is a known risk factor for post-menopausal breast cancer and may increase risk for triple negative breast cancer in premenopausal women."( Algotar, AM; Altbach, M; Centuori, S; Chalasani, P; Chow, HS; Galons, JP; Guillen-Rodriguez, J; Huang, C; Martinez, JA; Pinto, L; Roe, DJ; Tapia, E; Thomson, CA; Trujillo, J; Villa-Guillen, DE, 2021)
"Obesity is a metabolic disease characterized by a state of chronic, low-grade inflammation and dominated by pro-inflammatory cytokines such as IL-6."( Albini, E; Belladonna, ML; Grohmann, U; Mondanelli, G; Orabona, C; Orecchini, E; Pallotta, MT; Ricci, G, 2021)
"Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota."( Andrade, JMO; Brandi, IV; da Costa, DV; de Carvalho, BMA; de F Lelis, D; de Oliveira Costa, T; de Paula, AMB; Guimarães, ALS; Guimarães, VHD; Machado, A; Oliveira, JR; Pereira, UA; Santos, RAS; Santos, SHS; Vieira, CR, 2021)
"Obesity is considered a pandemic responsible for millions of deaths worldwide for many years."( Boumiza, R; Charlot, A; Roux, M; Zoll, J, 2021)
"The prevalence of obesity is increasing, resulting in an increase in the number of surgeries performed to treat obesity and diseases induced by obesity."( Kim, TK, 2021)
"Obesity is currently a major epidemic in the developed world."( Baixeras, E; Ciccocioppo, R; Decara, J; Gavito, AL; Hernandez-Folgado, L; Jagerovic, N; Rodríguez de Fonseca, F; Soverchia, L; Tovar, R; Vargas, A, 2021)
"Obesity is considered as a risk factor of osteoarthritis (OA), but the precise relationship is still poorly understood."( Dong, X; Gu, H; He, J; Jiang, M; Liu, L; Sun, Y; Yao, J, 2021)
"Patients with obesity are prescribed more opioids than the general population."( Andrell, P; Lundberg, CE; Rosengren, A; Sandström, TZ; Svensson, CJ; Thörn, SE; Wolf, A, 2022)
"Obesity is a pandemic condition of complex etiology, resulting from the increasing exposition to obesogenic environmental factors combined with genetic susceptibility."( Bozza, PT; Carneiro, JRI; da Fonseca, ACP; Kohlrausch, FB; Maya-Monteiro, CM; Mello, CB; Rolando, JM; Salum, KCR; Zembrzuski, VM, 2021)
"While obesity is a modifiable risk factor for musculoskeletal pain, the role of adiposity is less clear."( Cicuttini, FM; Estee, MM; Fairley, JL; Hussain, SM; McLean, EC; Peiris, WL; Ranger, TA; Romero, L; Urquhart, DM, 2021)
"Obesity is one of the main risk factors for the development gestational diabetes mellitus (GDM)."( Atzori, L; Dessì, A; Facchinetti, F; Fanos, V; Monari, F; Neri, I; Noto, A; Petrella, E; Pintus, R; Piras, C, 2022)
"Obesity is a global epidemic that affects the lives and health of millions of people."( Fu, J; Wang, Y; Zhou, Y, 2021)
"Obesity is now recognized as a disease."( Byeon, JE; Choi, SH; Choi, WI; Go, Y; Ham, HJ; Harris, RA; Jeon, JH; Jeon, YH; Kang, HJ; Kim, DW; Kim, HJ; Kim, MJ; Lee, IK; Lee, JY; Lee, YK; Min, BK; Park, S; Wende, AR, 2021)
"Obesity is a major contributor to inflammation and oxidative stress that are key underlying causes for insulin resistance (IR) and diabetes."( Bandinelli, M; Boddi, M; Chiostri, M; Coppo, M; Modesti, PA; Poggesi, L, 2022)
"Children with obesity are at higher risk for developing cardiometabolic diseases that once were considered health conditions of adults."( Figueroa, A; Flores-Ramírez, AG; Garay-Sevilla, ME; Maharaj, A; Tovar-Villegas, VI, 2021)
"Epidemic obesity is the most important risk factor for prediabetes and type 2 diabetes (T2D) in youth as it is in adults."( Balkhiyarova, Z; Bianchi, M; Chioma, L; Dallapiccola, B; Kaakinen, M; Luciano, R; Manco, M; Prokopenko, I; Shmeliov, A; Ulrich, A, 2022)
"Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer."( Alexandersson, I; Aouadi, M; Arifen, N; Boucher, J; Chen, P; Hagberg, CE; Harms, MJ; Hyvönen, MT; Knibbe, C; Krämer, N; Kutschke, M; Lang, S; Li, Q; Salehzadeh, F; Silva Cascales, H; Spalding, KL; Terezaki, E; Thorell, A, 2021)
"Obesity is a significant risk factor for arrhythmic cardiovascular death."( Coronel, R; Ernault, AC; Meijborg, VMF, 2021)
"Obesity is a major public health problem of our time as a risk factor for cardiometabolic disease and the available pharmacological tools needed to tackle the obesity pandemic are insufficient."( Abbaci, A; Biondi, O; Boullier, A; Feve, B; Forgez, P; Liu, J; Marie, N; Melander, O; Moldes, M; Morichon, R; Stadler, N; Wu, Z, 2021)
"Obesity is a globally growing problem."( Karlsson, S; Patavoukas, E; Sterpu, I; Wallstrom, T; Wiberg-Itzel, E, 2022)
"Obesity is a growing epidemic within the USA."( Bjalme-Evans, M; Krauthamer, M; Singh, G, 2022)
"Obesity is a chronic, multifactorial, relapsing disease."( Del Prato, S; Gallwitz, B; Holst, JJ; Meier, JJ, 2022)
"Obesity is recognized as an independent risk factor for cardiovascular diseases and is an important contributor to cardiac mortality."( Costa, CAD; Daleprane, JB; de Andrade Soares, R; de Araújo, CA; de Bem, GF; de Moraes Arnoso, BJ; de Moura, RS; Fernandes-Santos, C; Magliaccio, FM; Ognibene, DT; Resende, AC; Santos, IB, 2022)
"Obesity is the most significant risk factor for the development of diabetes."( Aras, M; Pape, J; Tchang, BG, 2021)
"Obesity is still a worldwide public health problem, requiring the development of adjuvant therapies to combat it."( Antônio de Oliveira Mendes, T; Aparecida Dos Reis Louzano, S; de Moura E Dias, M; Gouveia Peluzio, MDC; Lopes da Conceição, L, 2022)
"Obesity is a major risk factor for lung disease development."( Adeyanju, O; Chen, SY; Guo, X; Huang, SK; Idell, S; Qian, G; Sunil, C; Tucker, TA, 2022)
"Obesity is a lipid metabolism disorder caused by genetic, medicinal, nutritional, and other environmental factors."( Choi, CI; Han, HK; Lee, HS; Lim, SH, 2021)
"Obesity is the cause of multiple metabolic disorders, and its incidence has been rapidly increasing worldwide."( Chen, C; Fang, M; Hong, X; Huang, J; Huang, R; Huang, X; Jin, X; Mi, Y; Peng, L; Qiu, Y; Ren, J; Wu, X; Yang, L; Yang, X; Yao, E; Zhao, Y; Zhou, Y; Zhuo, R, 2022)
"Obesity is associated with an increased risk of an iron deficiency; however, a synergistic relationship between iron and lipid homeostasis was also observed."( Chang, JS; Chen, SH; Chuang, YK; Faradina, A; Huang, SY; Lee, YC; Skalny, AV; Tinkov, AA; Tseng, SH; Tung, TH, 2021)
"Obesity is considered an important risk factor for many metabolic disorders, especially type 2 diabetes mellitus, and microRNAs (miRNAs) play a vital role in the development of type 2 diabetes mellitus."( Chang, Y; Chu, X; Li, M; Ma, D; Pan, C; Tang, Y; Wang, C; Wang, J; Xiong, J; Yang, X; Yuan, C; Zhang, J; Zhu, J, 2022)
"Obesity is a public health problem characterized by increased body weight due to abnormal adipose tissue expansion."( Khan, MI; Khan, MZ; Kim, JD; Kim, MY; Lee, YB; Shin, JH; Shin, TS, 2021)
"Diet-induced obesity is a commonly used model of obesity, but when applied to other disease models like acute respiratory distress syndrome, pneumonia, and asthma, it yields widely divergent."( Bivona, JJ; Dixon, AE; Kokoszynska, M; Poynter, ME; Reed, LF; Suratt, BT; Ubags, ND; Ventrone, S; Wargo, MJ, 2021)
"Obesity, is an increasingly global public health problem associated complications."( Ao, H; Chen, L; Peng, C; Tang, F; Wan, Y; Wu, JJ; Xia, J; Xu, JF; Yang, Y, 2022)
"Obesity is a complex condition that is influenced by socioeconomic status, ethnicity, genetics, age, and diet."( Hernandez-Castillo, C; Shuck, SC, 2021)
"Obesity is a chronic condition whose management is a critical challenge for physicians."( Amatrudo, F; Colao, A; Graziadio, C; Liccardi, A; Montò, T; Muscogiuri, G; Negri, M; Patalano, R; Pivonello, C; Pivonello, R, 2022)
"Obesity is a heterogeneous condition that is affected by physiological, behavioral, and environmental factors."( Dan, O; Levy, I; Wertheimer, EK, 2022)
"Obesity is a major risk factor for cardiovascular disease, diabetes, osteoarthritis, and some cancers."( Doggrell, SA, 2022)
"Obesity is significantly associated with profuse sweating, thus the increase in hair cortisol levels in obese individuals could partly be the result of a higher incidence of sweating in these individuals."( Abdulateef, DS, 2021)
"The prevalence of obesity is high and increasing worldwide."( Alzughayyar, D; Anand, C; Englert, H; Hahn, A; Husain, S; Koeder, C; Kranz, RM; Schoch, N, 2022)
"Obesity is linked to lower intestinal uptake and blood levels of PSs, but its effects in terms of neuroinflammation-if any-remain unknown."( Bechmann, I; Brkovic, IB; Ceglarek, U; Chey, S; Isermann, B; Landmann, J; Leyh, J; Lütjohann, D; Reinicke, M; Wassermann, C; Zimmermann, S, 2021)
"Obesity is closely related to asthma."( Cai, W; He, X; Hu, J; Miao, J, 2022)
"Obesity is characterized as abnormal or excessive fat accumulation harmful to one's health, linked to hormonal imbalances, cardiovascular illness, and coronary artery disease."( Chen, TC; Ho, YY; Ke, YC; Lin, FH; Lin, JN; Tang, RC; Yang, IH, 2021)
"The prevalence of obesity is increasing globally."( Bandrés, F; Castrillón, EV; Chicharro, LM; López-Picado, A; Moreno Lopera, C; Paterna, ABR; Portolés-Pérez, A; Rubio, MA; Sánchez Pernaute, A; Torres García, AJ, 2022)
"Obesity is one of the most common nutritional disorders in dogs and cats and is related to the development metabolic comorbidities."( Amaral, AR; Brunetto, MA; da Silva, FL; de Oliveira Roberti Filho, F; Ernandes, MC; Ferreira, CS; Oba, PM; Rentas, MF; Vendramini, THA, 2022)
"Obesity is a major risk factor for various metabolic diseases, including metabolic syndrome and type-2 diabetes."( He, Q; Ma, D; Zhang, H; Zhang, W; Zhang, Y, 2022)
"Although obesity is one of the main causes of chronic kidney disease, the expression pattern of urinary EV RNA in obesity is uncertain."( Bae, YU; Cho, HC; Choi, D; Choi, JS; Han, DC; Jeon, JS; Kim, H; Kim, S; Kim, SH; Kwon, SH; Lee, H; Noh, H; Woo, J, 2022)
"Obesity is associated with an increased risk of several neurological and psychiatric diseases, but few studies report the contribution of biological features in the occurrence of mood disorders in obese patients."( Amadieu, C; Bindels, LB; Cani, PD; Cnop, M; Cserjesi, R; Delzenne, NM; Demeure, R; Hanhineva, K; Kärkkäinen, O; Klein, O; Leyrolle, Q; Luminet, O; Neyrinck, AM; Paquot, N; Rodriguez, J; Thissen, JP, 2021)
"Severe obesity is associated with an absolute deficiency in bacterial biotin producers and transporters, whose abundances correlate with host metabolic and inflammatory phenotypes."( Adriouch, S; Amouyal, C; André, S; Andreelli, F; Aron-Wisnewsky, J; Assmann, KE; Bäckhed, F; Belda, E; Blüher, M; Bork, P; Chakaroun, R; Chilloux, J; Clément, K; Coelho, LP; Dao, MC; Das, P; Debédat, J; Dumas, ME; Ehrlich, SD; Falony, G; Fellahi, S; Forslund, S; Galan, P; Galleron, N; Gøtze, JP; Hansen, T; Hansen, TH; Hercberg, S; Holmes, B; Holst, J; Ji, B; Krogh Pedersen, H; Køber, L; Le Chatelier, E; Le Roy, T; Le, P; Letunic, I; Lewinter, C; Mannerås-Holm, L; Marquet, F; Myridakis, A; Nielsen, J; Nielsen, T; Oppert, JM; Pedersen, OB; Pelloux, V; Pons, N; Prifti, E; Quinquis, B; Raes, J; Rouault, C; Roume, H; Salem, JE; Sokolovska, N; Stumvoll, M; Søndertoft, NB; Touch, S; Tremaroli, V; Vestergaard, H; Vieira-Silva, S; Voland, L; Zucker, JD, 2022)
"Obesity is often associated with hyperinsulinemia due to insulin resistance."( Akheruzzaman, M; Dhurandhar, NV; Feizy, Z; Hegde, V; Shin, AC; Siddik, MAB, 2022)
"Overweight and obesity are risk factors for many diseases, nutrition leading to these phenomena is not only a question of disbalance between energy intake and expenditure, but also the presence of micronutrients."( Kuta, J; Lokvencová, L; Zvěřina, O, 2021)
"Obesity is occurring due to continue taken high fat diet; this is the fast-growing problem reaching epidemic proportion globally."( Fang, C; Liu, Y; Tang, L; Tang, S; Xu, Y, 2022)
"Obesity is a global epidemic associated with multiple severe diseases."( Beke, G; Boros, A; Bozó, É; Éles, J; Greiner, I; Huszár, J; Kardos, P; Katalin Szalai, K, 2022)
"Patients with obesity are considered to be at high risk of acute respiratory failure (ARF) after extubation in intensive care unit (ICU)."( De Jong, A; Huguet, H; Jaber, S; Molinari, N, 2022)
"Obesity is a global health problem needing urgent research."( Gancarz, M; Kasprzak-Drozd, K; Kondracka, A; Oniszczuk, A; Oniszczuk, T; Rusinek, R, 2022)
"In conclusion, obesity is characterized by impaired secretion of GI hormones, with reduced postprandial satiety, particularly in individuals with obesity class III."( Akersveen Boyesen, G; Aukan, MI; Coutinho, S; DeBenedictis, JN; Haagensli Ollestad, K; Martins, C; Nymo, S; Rehfeld, JF, 2022)
"Obesity is associated with hypothalamic-pituitary-testicular axis dysregulation in males."( Davey, RA; Grossmann, M; Venkatesh, VS; Zajac, JD, 2022)
"Obesity is a medical condition associated with metabolic disorders and low-grade systemic inflammation."( Arora, H; Farber, N; Khodamoradi, K; Khosravizadeh, Z; Mallepalli, S; Seetharam, D, 2022)
"Obesity is a major public health problem."( Dirinck, E; Hermans, N; Jorens, PG; Lammens, C; Malhotra-Kumar, S; Mortelé, O; van Nuijs, ALN; Xavier, BB, 2022)
"Obesity is known to be associated with an altered thermoregulation as well as a dysregulation of sympathetic nervous system (SNS)."( Cammarata, G; Cannavaro, D; Ferrulli, A; Gandini, S; Luzi, F; Luzi, L; Macrì, C; Massarini, S; Redaelli, V; Terruzzi, I, 2022)
"Obesity is known to cause sexual dysfunction including erectile dysfunction and poor semen quality."( Alver, A; Artas, G; Bulmus, O; Canpolat, S; Gungor, IH; Kaya Tektemur, N; Kelestimur, H; Ozcan, M; Sahin, E; Turk, G; Ulker, N; Yardimci, A, 2022)
"Obesity is becoming increasingly common all over the world and global strategies are accordingly being developed to prevent it."( Otles, S; Selek Aksoy, I, 2022)
"In vivo, obesity is associated with chronic inflammation of white adipose tissue, including accumulation of neutrophils, infiltration by IFNγ/TNFα-producing immune cells, and ASC dysfunction."( Bertheuil, N; Bescher, N; Bezier, I; Dulong, J; Latour, M; Léonard, S; Loisel, S; Monnier, D; Monvoisin, C; Rossille, D; Roulois, D; Tarte, K, 2022)
"Obesity is becoming a major public health problem due to excess dietary fat intake."( Fan, K; Gao, H; Huang, Y; Ji, H; Li, C; Li, Y; Xu, H; Xu, Q; Zhao, L; Zheng, H; Zheng, Y, 2022)
"Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening human health."( Liu, Y; Luo, X, 2022)
"Obesity is a health and medical problem and is known as the accumulation of fat that increases the risk of cardiovascular, type 2 diabetes mellitus, and infertility."( Hu, S; Li, B; Li, J, 2022)
"Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic inflammation."( Bonafè, M; Dani, C; Di Mercurio, E; Giordano, A; Guerrieri, M; Lezoche, G; Matacchione, G; Olivieri, F; Perugini, J; Prattichizzo, F; Sabbatinelli, J; Senzacqua, M; Storci, G, 2022)
"Maternal obesity is correlated with fetal outcomes, perhaps because of problems with hormonal signaling and exacerbation of inflammation in the maternal metabolic environment."( de Oliveira, JL; Ferreira, MS; Ignácio-Souza, L; Lima, BS; Milanski, M; Miyamoto, JÉ; Sanches, APV; Simino, LAP; Torsoni, AS; Torsoni, MA, 2022)
"HFD-induced obesity is characterized by sustained, low-grade inflammation in adipose tissue, while macrophage infiltration plays a crucial role in inflammation."( Bian, J; Guo, W; Pan, C; Qin, P; Si, L; Wei, K; Xia, Y; Zhang, Q; Zhao, X; Zhu, W, 2022)
"Obesity is associated with increased serum fibrinogen level."( Choe, HM; Gao, K; Han, SZ; Kang, JD; Li, ZY; Luo, ZB; Paek, HJ; Quan, BH; Yin, XJ, 2022)
"Obesity is highly prevalent in breast cancer patients and is associated with increased recurrence and breast cancer-specific mortality."( Annett, S; Fox, OW; Robson, T; Vareslija, D, 2022)
"Obesity is a common comorbid condition in adult asthmatics and known as a feature of asthma severity."( Ban, GY; Cao, TBT; Kim, SH; Moon, JY; Park, HS; Yoo, HJ, 2022)
"Obesity is considered as a major public health concern with strong economic and social burdens."( Augsburger, M; Bararpour, N; Fracasso, T; Gasser, M; Gilardi, F; Lenglet, S; Sajic, T; Thomas, A; Wiskott, K, 2022)
"The incidence of obesity is rising owing to the modern sedentary lifestyle that leads to insulin resistance and increased levels of free fatty acids, predisposing tissues to utilize more lipids with less glucose uptake."( El-Kadi, AOS; El-Sherbeni, AA; Isse, FA, 2022)
"Obesity is an established risk factor for higher SARS-CoV-2 viral loads, severe COVID-19 pneumonia requiring hospitalization, and worse outcomes."( Cao, Y; Du, K; Faizy, A; Lu, X; Luo, Z; Piomelli, D; Shan, J; Sun, L; Sun, Q; Yang, Q; Zhang, K, 2022)
"For example, obesity is involved in the onset of cataracts."( Eom, Y; Han, YM; Jang, YN; Jeong, JH; Jung, TW; Kim, HM; Lee, YJ; Seo, HS; Song, JS, 2022)
"Obesity is also associated with increases in perivascular fat that expresses proinflammatory markers including SAA (serum amyloid A)."( Cassis, LA; de Beer, FC; Dugan, AJ; Ji, A; Leung, SW; Noffsinger, VP; Shridas, P; Tannock, LR; Thatcher, SE; Trumbauer, AC; Webb, NR, 2022)
"Obesity is the major driver of the global epidemic in type 2 diabetes (T2D)."( Cui, Y; Gavrilova, O; Haspula, D; Kimura, T; König, GM; Kostenis, E; Lu, H; Pydi, SP; Steinberg, GR; Wang, L; Wess, J, 2022)
"Women with obesity are likely to experience longer lengths of labor and are at an increased risk of cesarean delivery."( Bounthavong, M; Hill, MG; Wei, RM, 2022)
"Obesity is a global health burden for which we do not yet have effective treatments for prevention or therapy."( Ferrante, C; Georgiev, MI; Marchev, AS; Mladenova, SG; Orlando, G; Savova, MS; Wabitsch, M, 2022)
"Obesity is a major concern for global health care systems."( Adamoski, D; Bakker, NVT; Büscher, J; Câmara, NOS; Castelucci, B; Castoldi, A; Castro, G; Consonni, SR; Correa-da-Silva, F; Curtis, J; Davanzo, GG; Dias, SMG; Donato, J; Favero de Aguiar, C; Monteiro, LB; Moraes-Vieira, PM; Pearce, EJ; Pereira, JADS; Prodonoff, JS; Reis, LMD; Ribeiro, G; Virgílio-da-Silva, JV, 2022)
"Obesity is more prevalent among African American individuals, increasing the risk for cardiorenal morbidity."( Bentur, OS; Bielopolski, D; Charytan, DM; Kost, RG; Singh, N; Tobin, JN; Vaughan, RD, 2022)
"Obesity is a chronic, relapsing condition characterized by excess body fat."( Bansal, A; Barouki, R; Blanc, E; Cave, MC; Chatterjee, S; Choudhury, M; Collier, D; Gilbertson, M; Heindel, JJ; Howard, S; Kassotis, C; Kim, MJ; Lagadic-Gossmann, D; Lind, L; Lustig, RH; Roepke, TA; Tomlinson, CR; Vondracek, J, 2022)
"Obesity is associated with low-grade chronic inflammation and has a remarkable role in the pathophysiology of metabolic complications."( Ahmed, F; Amin, MT; Begum, R; Bhowmik, DR; Hossain, MS; Islam, MA; Ripon, MAR; Roy, S, 2022)
"In contrast, obesity is associated with reduced life expectancy in the population in general and is associated with an increased risk for type 2 diabetes, cardiovascular disease and other health problems."( Bradley, P, 2022)
"Obesity is associated with an increased incidence and aggressiveness of breast cancer and is estimated to increment the development of this tumor by 50 to 86%."( Cabrera-Quintero, AJ; Flores-García, LC; García-García, E; Hernández-Juárez, AJ; Méndez, JP; Meraz-Cruz, N; Naranjo-Meneses, MA; Pedraza-Sánchez, S; Ramírez-Ruíz, A; Romero-Córdoba, SL; Vadillo-Ortega, F; Ventura-Gallegos, JL; Zentella-Dehesa, A, 2022)
"Since obesity is a critical risk factor for cardiovascular diseases and mortality, the management of obesity is an urgent issue."( Chen, L; Ishigami, T; Kaneko, A; Kawai, Y; Mitsuma, T; Namiki, T; Saito, R; Uneda, K; Yamada, T, 2022)
"Obesity is a major public health concern in developed and even developing countries worldwide."( Akbarzadeh, M; Daneshpour, MS; Hedayati, M; Mesbah-Namin, SA; Najd Hassan Bonab, L; Nezhadali, M, 2022)
"Children with obesity is associated with a higher risk of cardiovascular disease (CV) risk in adulthood."( Hao, G; Liang, X; Qu, P; Ren, Y; Tang, X; Xi, B, 2023)
"Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known."( Aune, D; Biessy, C; Christakoudi, S; Colorado-Yohar, SM; Crous-Bou, M; Dossus, L; Freisling, H; Gicquiau, A; Grioni, S; Gunter, MJ; Heath, AK; Huybrechts, I; Idahl, A; Kaaks, R; Katzke, V; Kliemann, N; May, AM; Murphy, N; Olsen, A; Ould Ammar, R; Pasanisi, F; Perez-Cornago, A; Playdon, MC; Rinaldi, S; Rylander, C; Sánchez, MJ; Sartor, H; Skeie, G; Tin Tin, S; Tjønneland, A; Weiderpass, E, 2022)
"Obesity is associated with the development of insulin resistance (IR) and type 2 diabetes for which exercise training (Ex) and dietary interventions (DI) are effective interventions that can improve IR."( Azali Alamdari, K; Khalafi, M; Rohani, H; Sakhaei, MH; Symonds, ME, 2023)
"Obesity is a leading preventable cause of death and a growing health problem worldwide with increasing rate in both adults and children."( KrishnaKuchipudi, GS; Prabhu, M, 2022)
"Obesity is associated with decreased concentrations of serum cholesterol."( Arbones-Mainar, JM; Baila-Rueda, L; Casamayor-Franco, MC; Cenarro, A; Civeira, F; Gracia-Rubio, I; Laclaustra, M; Lamiquiz-Moneo, I; Marco-Benedi, V, 2022)
"Obesity is an important cause of diseases such as type 2 diabetes, non-alcoholic fatty liver and atherosclerosis."( Chen, L; Feng, J; Ge, Y; Guan, F; Han, H; Lv, Y; Xu, M; Yang, X; Zhang, M; Zhang, Y; Zhao, J; Zhao, T, 2022)
"Thus, obesity is an economic and social burden in developed countries."( Chakraborty, A; Chakraborty, M; Gu, C; Huang, D; Mukherjee, S; Pearce, KH; Shears, SB; Stashko, MA; Wang, H; Wang, X; Zhou, Y; Zong, G, 2022)
"The prevalence of obesity is increasing around the world at an alarming rate."( Amin, MR; Aschbacher, K; Azgomi, HF; Faghih, RT; Pednekar, DD; van Wietmarschen, H, 2022)
"Obesity is not only viewed as a chronic aggressive disorder but is also associated with an increased risk for various diseases."( Chang, YH; Hung, HY, 2022)
"Current time obesity is the major challenges globally and the incidence of the obesity has raised dramatically in current years."( Bai, F; Li, Y; Sun, D; Zhang, L, 2022)
"Obesity is an increasingly alarming public health threat, with nearly 20% of children classified as obese in the United States today."( Al-Uzri, A; Atz, AM; Carreño, FO; Delmore, P; Edginton, AN; Ford, JL; Gerhart, JG; Gonzalez, D; Muller, WJ; Perrin, EM; Watt, KM, 2022)
"Obesity is closely associated with nonalcoholic fatty liver disease (NAFLD), a highly prevalent disease without any approved medication."( Germanidis, GS; Giouleme, O; Goulas, A; Goulis, DG; Polyzos, SA, 2022)
"Obesity is a serious public health problem associated with excessive food intake."( Akbulut, T; Akkoc, RF; Aksoy, A; Aydin, S; Aydin, Y; Cinar, V; Kalayci, M; Karagoz, ZK; Kuloglu, T; Sahin, I; Ugur, K; Uslu, A; Yalcin, MH; Yardim, M, 2022)
"Obesity is a chronic disease associated with increased morbidity and mortality."( Koldemir Gündüz, M, 2022)
"Overweight and obesity are significantly associated with metabolic syndrome."( Kar, SS; Krishnamoorthy, Y; Murali, S; Rajaa, S; Sahoo, J, 2022)
"Obesity is related to many pathophysiological changes that may result in altered drug disposition."( Chen, K; Deng, C; Ding, J; Lin, Y; Luo, P; Pei, Q; Yang, G; Zhu, L; Zhu, S, 2022)
"Obesity is characterized by elevated lipids, insulin resistance and relative hypogonadotropic hypogonadism, reducing fertility and increasing risk of pregnancy complications and birth defects."( Bradford, AP; Kuhn, K; McDonald, R; Nguyen, TB; Santoro, N; Schauer, I; Tannous, A, 2022)
"Obesity is considered a risk factor in CRC development through inflammation, metabolic, and signaling processes."( Chira, A; Maerescu, CM; Martinez-Sanchez, MA; Mierlita, D; Nuñez-Sanchez, MA; Ramos-Molina, B; Ruiz-Alcaraz, AJ; Rusu, AV; Socol, CT; Trif, M, 2022)
"Obesity is a growing worldwide health problem, affecting many people due to excessive saturated fat consumption, lack of exercise, or a sedentary lifestyle."( Alba, G; Flores-Barragán, A; Flores-Cordero, JA; Jiménez-Cortegana, C; Pérez-Pérez, A; Sánchez-Margalet, V, 2022)
"Obesity is a serious health problem in modern life and increases the risk of many comorbidities including iron dyshomeostasis."( Jiang, C; Li, J; Li, Y; Liao, N; Liu, G; Pang, B; Shao, D; Shi, J; Xu, F, 2023)
"Obesity is considered a global crisis because of its increased risk factors triggered by lifestyle changes."( Dicky John, DG; Murali, A; Prabhakar, L; Singh, SR, 2023)
"Obesity is associated with impaired semen quality."( Andersen, E; Barrès, R; Dehestani, Y; Duun, OM; Holst, JJ; Ingerslev, LR; Janus, C; Jensen, SBK; Juhl, CR; Kjøller, ET; Lundgren, JR; Madsbad, S; Saupstad, M; Stallknecht, BM; Torekov, SS, 2022)
"Overweight and obesity are growing public health concerns worldwide."( El-Halafawy, YM; Elshazly, M; Mohamed, DZ; Mohamed, TMK; Wahab, KAE, 2022)
"Obesity is an extensive health problem worldwide that is frequently associated with diabetes."( Lungkaphin, A; Pengrattanachot, N; Thongnak, L, 2022)
"Maternal obesity is associated with complications of pregnancy and increases the infant's risk of developing obesity, diabetes and cardiovascular disease later in life."( Berveiller, P; Dieudonné, MN; Dos Santos, E; Hernández, MH; Priou, C; Rodriguez, Y; Vialard, F, 2022)
"Vasectomy and obesity are associated with an increased risk of advanced PC."( Armstrong, BK; Bang, A; Banks, E; Chiam, K; Egger, S; Nair-Shalliker, V; O'Connell, DL; Patel, MI; Smith, DP; Steinberg, J; Yu, XQ, 2022)
"Obesity is currently a global issue and is a major cause of the metabolic disorder, including dyslipidemia."( Amar, N; Chandra, LA; Firani, NK; Irnandi, DF; Nurkolis, F; Permatasari, HK; Prijadi, B; Riawan, W; Subali, AD; Yusuf, M; Yusuf, VM, 2022)
"Obesity is a complex multifactorial abnormality that has a well-confirmed genetic basis."( Anyżewska, A; Bertrandt, J; Garbacz, A; Leońska-Duniec, A; Lepionka, T; Maculewicz, E; Mastalerz, A; Szarska, E; Łakomy, R, 2022)
"Obesity is a global medical problem; its common form is known as diet-induced obesity (DIO); however, there are several rare genetic disorders, such as Prader-Willi syndrome (PWS), that are also associated with obesity (genetic-induced obesity, GIO)."( Azar, S; Baraghithy, S; Ben-Cnaan, E; Hinden, L; Hirsch, S; Permyakova, A; Tam, J, 2022)
"Obesity is associated with an increased risk of colon cancer."( Bowers, LW; Coleman, MF; Dannenberg, AJ; Glenny, EM; Goldbaum, A; Himbert, C; Hursting, SD; Lanman, NA; Montgomery, SA; Punjala, A; Roper, J; Ulrich, CM; Yang, P, 2022)
"Obesity is a colon cancer risk and/or progression factor, but the underlying mechanisms are incompletely understood."( Bowers, LW; Coleman, MF; Dannenberg, AJ; Glenny, EM; Goldbaum, A; Himbert, C; Hursting, SD; Lanman, NA; Montgomery, SA; Punjala, A; Roper, J; Ulrich, CM; Yang, P, 2022)
"Obesity is a multifactorial disease, defined as excessive fat deposition in adipose tissue."( Barragán-Bonilla, MI; Espinoza-Rojo, M; Flores-Alfaro, E; Flores-Cortez, YA; González-Calixto, C; Mendoza-Bello, JM, 2022)
"Obesity is a chronic disease that results in substantial global morbidity and mortality."( Ahmad, NN; Alves, B; Aronne, LJ; Bunck, MC; Connery, L; Jastreboff, AM; Kiyosue, A; Liu, B; Stefanski, A; Wharton, S; Zhang, S, 2022)
"Obesity is common in captive reptiles, and reptiles are increasingly popular as companion animals and in physiological research."( Kristensen, L; Malte, CL; Malte, H; Wang, T; Williams, CJA, 2022)
"Obesity is mainly caused by excess energy intake and physical inactivity, and the number of overweight/obese individuals has been steadily increasing for decades."( Carpinelli, A; Carvalho, CRO; Evangelista, FS; Goedcke, J; Lucena, CF; Veras, K, 2022)
"Obesity is a complex and chronic disease that raises the risk of various complications."( Al-Najim, W; Alabduljabbar, K; le Roux, CW, 2022)
"Maternal obesity is associated with impaired placental function, resulting in restricted placental blood vessel development and fetal developmental disorders."( Miao, Y; Peng, J; Wang, M; Wang, Z; Wei, H; Zhou, Y, 2022)
"Obesity is associated with low-grade inflammation and disturbances in hepatic metabolism."( Antunes, GC; Cintra, DE; da Silva, ASR; de Lima, RD; Macêdo, APA; Muñoz, VR; Pauli, JR; Prada, PO; Romeiro, CF; Ropelle, ER; Simabuco, FM; Vieira, RFL; Zambalde, EP, 2022)
"Since obesity is a significant risk factor for PCa, and there is a correlation between levels of the obesity-associated hormone leptin and PCa development, here we investigated the functional relationship between leptin and miR-628 regulation in PCa."( Afzal, Z; Arthur, E; Cagle, P; Chijioke, J; Collins, SP; Deep, G; Kedir, H; Kumar, D; Moore, J; Niture, S; Qi, Q; Ramalinga, M; Rios-Colon, L; Sharma, M; Srivastava, A; Suy, S, 2022)
"Obesity is associated with inflammation, insulin resistance, and type 2 diabetes, which are major risk factors for CVD."( den Hartigh, LJ; Irwin, AD; Omer, M; Storey, C; Tang, C; Vaisar, T; Wang, S, 2022)
"Obesity is a chronic process and could activate various inflammatory responses, which in turn aggravates obesity and related metabolic syndrome."( Feng, Y; Gao, T; Li, Y; Shen, P; Tai, C; Wang, B; Wang, L; Xie, Y; Zeng, S, 2022)
"Obesity is associated with alterations in cholesterol and bile acid (BA) metabolism."( Acosta, A; Burton, D; Calderon, G; Camilleri, M; Campos, A; Cifuentes, L; Franks, S; Gonzalez-Izundegui, D; Hashem, AM; Hurtado, MD; Lanza, IR; McRae, A; Petterson, XM; Ricardo-Silgado, ML, 2022)
"Women with obesity are at increased risk of complications during and after labor and delivery, including puerperal infection and cesarean delivery."( Edwards, RK; Peck, JD; Pierce, SL; Standerfer, E; Zornes, C, 2022)
"Obesity is a public health challenge worldwide."( Fu, H; Jiang, J; Jing, X; Liang, Y; Wang, R; Yang, M, 2022)
"Obesity is one of the main public health problems in Mexico and the world and one from which a large number of pathologies derive."( Aguilar-Galarza, A; Anaya-Loyola, MA; Anzures-Cortes, ML; Cadena-López, RO; Flores-Viveros, KL; García-Gasca, T; García-Muñoz, W; Haddad-Talancón, L; Hernández-Rodríguez, LV; Moreno-Celis, U; Rodríguez-García, VM; Velázquez-Sánchez, C, 2022)
"Obesity is one of the circadian rhythm disorders (CRD)-mediated metabolic disorder syndromes."( Hu, C; Hu, S; Liu, Z; Luo, L; Zeng, L; Zhang, H; Zhao, S, 2022)
"Maternal obesity is associated with an increased risk of adverse pregnancy outcomes including stillbirth, and their etiology is thought to be related to placental and fetal hypoxia."( Atkins, KL; Goetzinger, KR; Shen, WB; Wang, B; Yang, P; Yao, R, 2022)
"On the one hand, obesity is a low-grade chronic inflammation causing insulin resistance, so polyphenols can reduce T2D risk by improving obesity."( Cao, J; Chen, L; He, X; Jiang, W; Ma, Y; Pu, Y; Xu, Y, 2022)
"Obesity is defined as an excessive accumulation of bodily fat, exceeding its physiological needs and adaptability."( Chudecka-Glaz, AM; Kukla, A; Misiek, M; Piotrowska, K, 2022)
"Obesity is the main factor involved in the onset of many diseases."( Chen, J; Hu, L; Ma, Q; Qian, D; Shan, A; Sun, B; Sun, Y; Wang, Z; Zhou, X, 2022)
"Obesity is the strongest risk factor for type 2 diabetes (T2D)."( Arguelles-Tello, FA; Barranco-Garduño, LM; Huerta-Cruz, JC; Kammar-García, A; Reyes-García, JG; Rocha-González, HI; Trejo-Jasso, CA, 2022)
"Obesity is a global epidemic that drives morbidity and mortality through cardiovascular disease, diabetes, and non-alcoholic fatty liver disease (NAFLD)."( Anez-Bustillos, L; Cho, BS; Dao, DT; Feigh, M; Fell, GL; Fraser, DA; Gura, KM; Ko, VH; Pan, A; Puder, M; Secor, JD; Yu, LJ, 2022)
"Obesity is one of the risk factors concerns of colorectal cancer (CRC), the most common type of gastrointestinal cancer, due to the changing lifestyle and especially diet."( Esmaeili, M; Ghaedi, K; Hajipour, M; Hashemi, M; Hushmandi, K; Mahdevar, M; Mirzaei, S; Mokhtari, K; Nasr-Esfahani, MH; Peymani, M, 2022)
"Obesity is one of the most common diseases of civilization, and approximately 13 % of the world's adult population is obese."( Krakowska, A; Krośniak, M; Muszyńska, B; Opoka, W; Rospond, B, 2022)
"Obesity is an abnormal or excessive accumulation of fat in the body that exacerbates metabolic and inflammatory processes, and impairs the health of afflicted individuals."( Fafutis-Morris, M; Franco-Arroyo, NN; López-Roa, RI; Márquez-Aguirre, AL; Roldán, E; Velázquez-Juárez, G; Viveros-Paredes, JM; Zepeda-Morales, ASM; Zepeda-Nuño, JS, 2022)
"Obesity is an abnormal fat accumulation disorder in the metabolic syndrome constellation, and a risk factor for diabetes, cardiovascular disorders, non-alcoholic fatty liver disease (NAFLD), and cancer."( Deepa, PR; Kumar, BK; Mandal, SK; Murugesan, S; Sharma, PK, 2022)
"The incidence of obesity is more prevalent in females than males globally."( Al-Hariri, M; Al-Muzafar, H, 2022)
"Although obesity is typically associated with metabolic co-morbidities, some people with obesity do not develop metabolic abnormalities."( Farabi, SS; Klein, S; Schweitzer, GG; Smith, GI; Stein, RI, 2022)
"Obesity is heterogeneous in its phenotype, and it is the accumulation of excess adipose tissue viscerally associated with insulin resistance, dyslipidaemia, inflammation, hypothalamic leptin resistance and gliosis that underpins the functional hypogonadism of obesity."( Grossmann, M; Wittert, G, 2022)
"Obesity is closely related to diabetes."( An, L; Deng, J; He, H; Li, X; Yang, M; Ye, X, 2022)
"The prevalence of obesity is increasing at an alarming rate and keeps on being one of the significant challenges of this century."( Ahmed, F; Amin, MT; Begum, R; Bhowmik, DR; Hossain, MS; Islam, MA; Roy, S, 2022)
"Overweight and obesity are associated with an increased risk of developing dementia and cognitive deficits."( Abedi, A; Amani, M; Mansouri, S; Mohammadi, P; Salari, AA, 2022)
"Obesity is a risk factor for various types of cancer."( Chin, H; Jun, KH; Kim, EY; Park, KB; Yoon, DJ, 2022)
"Obesity is associated with low-grade chronic inflammation and oxidative stress, affecting the brain's reward system by decreasing dopaminergic neurotransmission."( Andrade, VM; Bitencourt, RM; Cavalheiro, EKFF; Cucker, L; da Silva, LE; Dal-Pizzol, F; Damiani, AP; Joaquim, L; Machado, RS; Magenis, ML; Michels, M; Oliveira, MP; Petronilho, F; Rezin, GT; Ribeiro, CB; Silva, MG; Tuon, T; Vilela, TC, 2022)
"Obesity is a syndrome of multifactorial etiology characterized by an excessive accumulation and release of fatty acids (FA) in adipose and non-adipose tissue."( Aristizábal, A; Barreto, GE; Castellanos, DB; González Santos, J; Martín-Jiménez, CA; Padilla-González, GF; Pinzón, A; Zuluaga, M, 2022)
"The increase in obesity is mainly due to polarisation - that is, normal-weight people remain of a normal weight, but overweight people tend to gain more weight and become obese."( Härkänen, T; Jousilahti, P; Laatikainen, T; Lundqvist, A; Männistö, S; Paalanen, L; Reinikainen, J; Tolonen, H; Zhou, Z, 2023)
"The increase in obesity is mainly due to polarisation - that is, normal-weight people remain of a normal weight, but overweight people tend to gain more weight and become obese."( Härkänen, T; Jousilahti, P; Laatikainen, T; Lundqvist, A; Männistö, S; Paalanen, L; Reinikainen, J; Tolonen, H; Zhou, Z, 2023)
"Obesity is an expanding global public health problem and a leading cause of metabolic disorders."( Huang, C; Li, L; Li, X; Lin, M; Shi, X; Wang, D; Wu, M; Zhang, X; Zhao, Y, 2022)
"Obesity is associated with low testosterone levels that could be caused by many mechanisms."( Abdel-Fadeil, MR; Eid, RMHM; Mohammed, WS; Muhammed, AA, 2022)
"Obesity is a chronic illness associated with several metabolic derangements and comorbidities (i."( Borrelli, A; Caccioppoli, C; Cignarelli, A; D'Oria, R; Genchi, VA; Giorgino, F; Lauriola, C; Palma, G; Rossi, E, 2022)
"Obesity is a multifactorial and complex disease that often manifests in early childhood with a lifelong burden."( Fischer-Posovszky, P; Hinney, A; Körner, A, 2022)
"Obesity is a widespread medical problem, for which many drugs have been developed, each with its own limitations."( Deng, Z; Fu, L; Fu, Z; Huang, H; Meng, C; Song, S, 2022)
"Obesity is complicated by inflammatory activation of the innate immune system."( Blüher, M; Dietrich, A; Gericke, M; Körner, A; Kovacs, P; Krasselt, M; Landgraf, K; Massier, L; Raulien, N; Rossol, M; Sommer, M; Thrum, S; Wagner, U, 2022)
"Obesity is a medical problem with an increased risk for other metabolic disorders like diabetes, heart problem, arthritis, etc."( Nachiappan, V; Suriagandhi, V, 2022)
"Obesity is one of the major global threats to human health and risk factors for cardiometabolic diseases and certain cancers."( Herzig, KH; Kamakura, R; Kovalainen, M; Lehto, VP; Raza, GS; Sodum, N, 2022)
"Obesity is associated with low-grade inflammation and increased systemic oxidative stress."( Adeshara, K; Akhi, R; Groop, PH; Härma, MA; Hörkkö, S; Hukkanen, J; Istomin, N; Koivukangas, V; Lehto, M; Nissinen, AE; Savolainen, MJ, 2022)
"Obesity is considered the primary environmental factor associated with morbidity and severity of wide-ranging inflammatory disorders."( Frascoli, M; Kang, J; Reboldi, A, 2022)
"Obesity is one of the major pandemics of the 21st century."( Franco, OL; Lima, HK; Lyssa, V; Marques, G; Petriz, B; Ribeiro, FM; Silva, MA, 2022)
"Obesity is a key risk factor of hypertension."( Bai, BL; Li, YQ; Lin, Y; Ma, LJ; Shi, L; Wang, H; Wu, HJ; Zhang, Q; Zou, JZ, 2022)
"Obesity is linked to reproductive disorders."( Basha, EH; El-Harty, YM; Elshwaikh, SL; Eltantawy, AF; Eltokhy, AKB; Heabah, NAE, 2022)
"Overweight and obesity are not associated with an unfavourable clinical course in COVID-19 patients admitted to a non-ICU ward and treated with 6 mg dexamethasone once daily."( Bos, WJW; Grutters, JC; Moeniralam, HS; Ocak, G; Paul Voorn, G; van de Garde, EMW; Wittermans, E, 2022)
"Obesity is an important risk factor for hyperuricemia."( Cheng, Y; Fang, Y; Ke, J; Ma, Y; Xu, Y; Yang, Y; Zhao, D, 2022)
"Obesity is an important risk factor for atrial fibrillation (AF), but a better mechanistic understanding of obesity-related atrial fibrillation is required."( Bapat, A; Das, S; Ellinor, PT; Grune, J; Hulsmans, M; Iwamoto, Y; Li, G; Milan, D; Nahrendorf, M; Rosenzweig, A; Schloss, MJ; Tedeschi, J; Xiao, L; Yamazoe, M; Yang, X; Yeri, A, 2022)
"Obesity is accompanied by a chronic low-grade inflammation associated with endothelial dysfunction and vascular complications."( Brabenec, L; Hellenthal, KEM; Kardell, M; Kintrup, S; Müller, M; Otto, M; Wagner, NM; Zurek-Leffers, F, 2022)
"Obesity is a risk factor for pneumonia."( Burnet, L; Collins, AM; Coombs, M; Ferreira, DM; Hales, C, 2022)
"Obesity is common and associated with unique phenotypic features in heart failure with preserved ejection fraction (HFpEF)."( Adamson, C; Al Habeeb, W; Alcocer Gamba, MA; Bachus, E; Cabrera Honorio, JW; Claggett, B; de Boer, RA; Desai, AS; Hernandez, AF; Inzucchi, SE; Jhund, PS; Kondo, T; Kosiborod, MN; Lam, CSP; Langkilde, AM; Lindholm, D; Litwin, SE; Martinez, F; McMurray, JJV; Nguyen Vinh, P; Petersson, M; Shah, SJ; Solomon, SD; Vaduganathan, M; Wilderäng, U, 2022)
"Obesity is common in patients with HFpEF and is associated with higher rates of heart failure hospitalization and worse health status."( Adamson, C; Al Habeeb, W; Alcocer Gamba, MA; Bachus, E; Cabrera Honorio, JW; Claggett, B; de Boer, RA; Desai, AS; Hernandez, AF; Inzucchi, SE; Jhund, PS; Kondo, T; Kosiborod, MN; Lam, CSP; Langkilde, AM; Lindholm, D; Litwin, SE; Martinez, F; McMurray, JJV; Nguyen Vinh, P; Petersson, M; Shah, SJ; Solomon, SD; Vaduganathan, M; Wilderäng, U, 2022)
"Obesity is not just a hypertrophy of the adipose tissue because it may become dysfunctional and inflamed resulting in increased insulin resistance."( Bronzeri, F; de Carvalho Cara, LG; de Cassia Rocha, A; Eliaschewitz, FG; Fogo, SL; Franco, DR; Gieremek, HW; Pedrosa, MR; Vidal, CM, 2022)
"Obesity is one of the risk factors for the onset of various metabolic diseases in dogs."( Funaba, M; Kazama, K; Kobayashi, T; Murakami, M; Onda, K; Shimokawa, F; Sugiyama, K; Sugiyama, Y; Yamashita, Y, 2022)
"Obesity is an epidemic with rising prevalence, and obese patients are predisposed to comorbid conditions that increase risk for thromboembolic events."( Bansal, A; Eisele, CD; Jain, R; Julian, K; Mausteller, KG; Patel, P, 2022)
"Obesity is the leading risk factor associated with Metabolic dysfunction Associated with Fatty Liver Disease (MAFLD), Insulin Resistance (IR), and type 2 diabetes (T2DM)."( Abdalla, M; El-Arabey, AA, 2022)
"Obesity is present in 40-70% of patients with the syndrome."( Baranowska-Bik, A, 2022)
"Overweight and obesity are typical risk factors for the increased prevalence and incidence of gout."( Geng, H; Jia, E; Liu, R; Ma, W; Wo, X; Yao, X; Zeng, Y; Zhan, Z; Zhang, J; Zhu, H, 2022)
"Obesity is characterized by visceral fat accumulation and various metabolic disturbances that cause metabolic syndrome and obesity-related cardiovascular diseases (ORCVDs)."( Node, K; Sawami, K; Tanaka, A, 2022)
"Obesity is a chronic health condition characterized by the accumulation of excessive body fat which can lead to and exacerbate cardiovascular disease, type-II diabetes, high blood pressure, and cancer through systemic inflammation."( Borri, A; Chan, J; Gardner, SH; Lucero, MY; Yadav, AK; Zhao, Z, 2022)
"Obesity is a multi-factorial metabolic syndrome that increases the risk of cardiovascular diseases, diabetes, and cancer."( Gopal, SS; Ponesakki, G; Sukhdeo, SV; Vallikannan, B, 2023)
"Obesity is nowadays a serious public health issue."( Huang, Y; Lin, F; Wang, Q; Xiao, M; Xue, C; Yang, Y; Ye, J; Zhang, N; Zheng, B, 2022)
"Obesity is an important risk factor for diabetes mellitus (DM) which is a major global health problem."( Howarth, FC; Qureshi, MA; Sultan, A, 2022)
"Obesity is a well-recognised risk factor for venous thromboembolism, and increased dosing of pharmacological prophylaxis is recommended in obese inpatients."( Bortz, H; Chee, A; McFadyen, JD; Yip, J, 2022)
"Obesity is associated with other diseases such as diabetes and cancer."( Barbosa-Dekker, AM; de Queiroz, EAIF; Dekker, RFH; Giordani, MA; Lira, C; Luvizotto, RAM; Nascimento, AF; Queiroz, DA; Ribeiro, MC; Silva, AZD, 2022)
"Obesity is a chronic metabolic disease declared as the 21st century pandemic by the World Health Organization."( Bulus, H; Keskin, M; Koca, AO; Öztürk, D, 2022)
"Obesity is a leading global health problem contributing to various chronic diseases, including type II diabetes mellitus (T2DM)."( Mathai, ML; McAinch, AJ; Shi, M; Su, XQ; Xu, G, 2022)
"Obesity is a systemic disease and represents one of the leading causes of death worldwide by constituting the main risk factor for a series of non-communicable diseases such as type 2 diabetes mellitus (T2DM), cardiovascular diseases and dyslipidemia."( Cătinean, A; Crăciun, AM; Ghervan, C; Popa Ilie, IR; Seicaru, EM, 2022)
"Obesity is currently one of the most important challenges to public health worldwide."( Ding, W; Gong, Y; He, Y; Jin, Y; Liang, X; Xia, X; Xie, Y; Yang, Y; Zhan, M, 2022)
"Obesity is a major risk factor for development and progression of NAFLD and weight loss is an effective intervention for the management of NAFLD."( Cholongitas, E; Koureta, E; Neokosmidis, G; Tsankof, A; Tziomalos, K; Veneti, S, 2022)
"Obesity is highly polygenic disease where several genetic variants have been reportedly associated with obesity in different ethnicities of the world."( Bosco Pesquero, J; Fatima, T; Fiaz, M; Kaukab Raja, G; Khalid, M; Maglio, C; Mehmood Raja, A; Mobeen Zafar, M; Nawaz, M; Saeed, S; Saqlain, M; Valadi, H, 2022)
"Obesity is a critical threat to global health, and brown adipose tissue (BAT) is a potential target for the treatment of obesity and comorbidities."( Gong, Z; Gu, P; Jiang, W; Jiang, Y; Wang, X; Zhang, H; Zhang, S; Zhang, Y; Zhu, Y, 2023)
"Obesity is a significant risk factor for both incidence and worse prognosis in estrogen receptor positive (ER+) BC."( Drai, E; Elkin, M; Hermano, E; Maimon, O; Maly, B; Meirovitz, A; Nahmias Blank, D; Peretz, T; Popovtzer, A; Rubinstein, AM; Sonnenblick, A; Vlodavsky, I, 2022)
"Obesity is regarded as a civilization disease that increases mortality and the risk of cardiovascular complications."( Horodnicka-Józwa, A; Jackowski, T; Petriczko, E; Safranow, K; Strączek, K; Szmit-Domagalska, J; Walczak, M, 2022)
"Obesity is a chronic metabolic disease caused by an imbalance between energy intake and expenditure during a long period and is characterized by adipose tissue disfunction and hepatic steatosis."( Fu, G; Li, H; Li, L; Zha, W; Zhu, G, 2022)
"Obesity is one of the main health problems in the world today, and dysbiosis seems to be one of the factors involved."( Barbeiro, DF; Carrilho, FJ; Cogliati, B; Duarte, SMB; Franco, LAM; Martins, RC; Moraes, BDGC; Neri, JMTR; Oliveira, CP; Oliveira, N; Sabino, EC; Stefano, JT; Vanni, DS, 2022)
"Obesity is commonly accompanied by chronic tissue inflammation and leads to insulin resistance."( Gan, Y; Guo, Q; Jia, J; Li, N; Shi, H; Zhang, L; Zhang, Y; Zhou, Y, 2022)
"Obesity is a complex disorder associated with immense health consequences including high risk of cardiovascular diseases, diabetes, and cancer."( Afrin, H; Ahsan, MA; Aldalbahi, A; Alvarado-Tenorio, B; Hassan, M; Islam, T; Noveron, JC; Nurunnabi, M; Pena-Zacarias, J, 2023)
"Obesity is related to increasing leptin and some inflammatory factors that are associated with low-grade inflammation."( Clark, CCT; Farazi, M; Jamili, S; Mirzaei, K; Rasaei, N; Shiraseb, F, 2022)
"Obesity is a major health problem worldwide."( Eliason, NL; Low, MJ; Martin, L; Sharpe, AL, 2022)
"Obesity is associated with increased occurrence of cognitive and mood disorders."( Kang, J; Milenkovic, D; Oteiza, PI, 2022)
"The pandemic of obesity is strongly related to increase of chronic kidney disease (CKD) prevalence."( Dika, Z; Domislovic, M; Domislovic, V; Fucek, M; Gellineo, L; Jelakovic, A; Jelakovic, B, 2022)
"Obesity is a risk factor for cerebrovascular diseases."( Huang, R; Liang, J; Ren, Y; Wang, H; Wu, Q; Xie, J; Yin, J; Zhang, M; Zhu, J, 2023)
"Obesity is currently the most common cause of metabolic diseases including type 2 diabetes and hyperlipidemia."( Kaneko, H; Kishikawa, Y; Koike, Y; Nobushi, Y; Shimba, S; Uchiyama, T; Wada, T, 2022)
"Obesity is associated with an increased risk of, and a poor prognosis for, postmenopausal (PM) breast cancer (BC)."( Aldakhlallah, R; Alluin, J; Chodosh, LA; Daisy, C; Dillon, D; Man, E; Merritt, L; Moses, MA; Pories, S; Roy, R; Shimura, T; Yang, J, 2022)
"Lead (Pb) and obesity are co-occurring risk factors for metabolic disorders."( Jiang, F; Sheng, Z; Wang, N; Zhang, Z; Zhou, S, 2022)
"Obesity is associated with metabolic syndrome (MBS), a cluster of components including central obesity, insulin resistance (IR), dyslipidemia, and hypertension."( Agayby, ASS; Demerdash, HM; Hany, M; Ibrahim, M; Torensma, B, 2022)
"Although obesity is caused by different factors, individual susceptibility to obesity differs among people under the same circumstances."( Ding, W; Pang, Y; Yang, N; Zan, M; Zhang, L; Zheng, Y, 2022)
"Asthma and obesity are both inflammatory complications of pregnancy and when combined contribute to an increased risk of uncontrolled asthma during pregnancy and poor perinatal outcomes."( Bhaumik, S; Clifton, VL; Lai, A; Lockett, J; Saif, Z; Salomon, C; Whitehead, JP, 2023)
"Obesity is a global epidemic elevating the risk of various metabolic disorders."( Chen, S; Feng, S; Gang, X; Gao, T; Liu, M; Tai, Y; Tian, H; Yang, X; Zhong, C, 2022)
"Obesity is a chief lifestyle disease globally and causes a significant increase in morbidities."( Balachandran, A; Kumar, P; Muhammad, T; Srivastava, S, 2022)
"Obesity is a complex multifactorial disorder with genetic and environmental factors."( Butler, MG; Kimonis, V; Mahmoud, R, 2022)
"Obesity is an increasing problem worldwide."( Hämäläinen, M; Moilanen, E; Peltola, R; Pemmari, T; Ryyti, R, 2022)
"Obesity is a known risk factor for the development of gastroesophageal reflux disease (GERD), Barrett's Esophagus (BE) and the progression to esophageal adenocarcinoma."( Altomare, DA; Andl, CD; Andl, T; Bernard, JN; Chinnaiyan, V; Le Bras, GF; Qureshi, MN, 2022)
"Obesity is an excessive accumulation of fat that exacerbates the metabolic and inflammatory processes."( Anguiano-Sevilla, LA; Camacho-Padilla, LG; Carrera-Quintanar, L; Delgado-Rizo, V; Franco-Torres, EM; García-Iglesias, T; López-Roa, RI; Rodríguez-Mejía, UU; Varela-Navarro, E; Velázquez-Juárez, G; Viveros-Paredes, JM; Zepeda-Morales, ASM; Zepeda-Nuño, JS, 2022)
"Sarcopenic obesity is a new category of obesity and is a specific condition of sarcopenia."( Guan, L; Li, T; Wang, X; Xi, Y; Xiao, R; Yu, K, 2022)
"Obesity is recognized as an independent risk factor for the development of kidney disease, which has led to the designation of obesity-related glomerulopathy (ORG)."( Martín-Taboada, M; Medina-Gómez, G; Morales, E; Sandino, J; Vila-Bedmar, R, 2022)
"Obesity is resulted from energy surplus and is characterized by abnormal adipose tissue accumulation and/or distribution."( Bai, C; Guan, Y; Huang, J; Kazumi, T; Nian, X; Niu, Z; Wang, Y; Wu, B; Zhao, J; Zuo, F, 2022)
"Obesity is a risk factor for severe airway obstruction and hypoxemia."( Gu, W; Wang, HT; Zhou, R, 2022)
"Obesity is defined as the excessive accumulation of body fat and is associated with an increased risk of developing major health problems such as cardiovascular disease, diabetes and stroke."( Brettle, H; Drummond, GR; Franks, AE; Jelinic, M; Petrovski, S; Tran, V; Vinh, A, 2022)
"Obesity is among the strongest risk factors for type 2 diabetes (T2D)."( Chen, H; Fan, N; Gou, S; Hui, X; Lai, L; Lan, T; Li, H; Li, Y; Liao, Y; Liu, Y; Nie, T; Suo, Y; Wang, H; Wang, J; Wu, D; Yan, Q; Zhao, Y; Zhuang, Z; Zou, Q, 2022)
"Obesity is a global pandemic that is causally linked to many life-threatening diseases."( Beyaz, S; Boyle, S; Corona, A; Furlan, A; Gablenz, EC; Giovanniello, J; Habel, J; Janowitz, T; Li, B; Rubino, R; Sharma, R; Shea, SD, 2022)
"Individuals with obesity are known to have increased inflammation, increased risk to select autoimmune diseases, impaired response to several infections, and impaired vaccine response."( Greene, E; MacIver, NJ, 2022)
"Obesity is one of the most important global health problems causing serious health risks and early death in human."( Adnan, AA; Gahzi, ST; Ibrahim, SA, 2022)
"Treating obesity is challenging as the treatment options have many limitations."( Abd El Maksoud, AI; Abourehab, MAS; Ali, MA; El Hassab, MA; Eldehna, WM; Elebeedy, D; Ghanem, A; Ibrahim, MH; Kamaly, OA; Saleh, A, 2022)
"Obesity is a consequence of the increased storage of triacylglycerol (TG)."( Bradić, I; Kargl, J; Korbelius, M; Kratky, D; Kuentzel, KB; Mihalič, ZN; Pirchheim, A; Rainer, S, 2022)
"Obesity is an established risk factor for metabolic disease."( Le, TT; Urasaki, Y, 2022)
"Obesity is a risk factor for many metabolic diseases."( Cai, S; Chen, D; Ding, C; Jin, S; Li, D; Li, H; Ma, M; Wang, Y; Xu, L; Zhang, O; Zhu, Y, 2022)
"Obesity is one of the major public health problems threatening the world, as well as a potential risk factor for chronic metabolic diseases."( Chen, X; Liu, X; Qiu, F; Sun, X; Wang, N; Wu, L; Yang, G; Zhang, C, 2022)
"Obesity is one of the leading health concerns in the United States."( Addis, VM; Boulnemour, KM; Ferrario, CR; Kennedy, RT; Micheli, DA; Nesbitt, KM; Sandoval, DA; Smith, KB; Vollbrecht, PJ, 2023)
"Obesity is a complex disease associated with excessive fat accumulation and numerous metabolic complications."( Bogdański, P; Michałowska, J; Miller-Kasprzak, E; Mostowska, A; Seraszek-Jaros, A, 2022)
"Obesity is one of the major health problems across the world and the leading cause of death."( Afzal, M; Al-Abbasi, FA; Alshehri, S; Kazmi, I; Sarim Imam, S; Shahid Nadeem, M, 2022)
"Maternal obesity is linked with reduced metabolic health and oocyte quality; therefore, infertile obese women are advised to lose weight before conception to increase pregnancy chances."( Bols, PEJ; De Neubourg, D; Leroy, JLMR; Marei, WFA; Moorkens, K; Smits, A, 2022)
"Obesity is a complex condition with multifactorial aetiopathogenesis."( Jonczyk, P; Kucharzewski, M; Potempa-Jeziorowska, M; Świętochowska, E, 2022)
"Obesity is a chronic disease associated with increased morbidity and mortality due to its complications."( Kıyıcı, S; Sancak, S; Sezer, H; Uygur, M; Yapıcı Eser, H; Yazıcı, D; Yumuk, V, 2023)
"Treating obesity is not only enabling weight loss but ameliorating complications related to obesity."( Kıyıcı, S; Sancak, S; Sezer, H; Uygur, M; Yapıcı Eser, H; Yazıcı, D; Yumuk, V, 2023)
"Obesity is a multifactorial metabolic disorder, growing in an alarming rate across the world."( Auti, PS; George, G; Paul, AT; Yadav, N, 2023)
"Obesity is accompanied by various metabolic pathologies provoking the development of dyslipidaemia, metabolic syndrome, type 2 diabetes mellitus, arterial hypertension, cardiovascular diseases and cancer."( Danilenko, AD; Osadchuk, AV; Osadchuk, LV, 2022)
"Obesity is a major predictive factor for the diabetic nephropathy (DN)."( Chen, J; Chen, S; Dai, X; Ge, C; Hui, J; Kuang, G; Kuang, Q; Liu, J; Luo, J; Sun, Y; Tan, J; Wang, L; Wang, Y; Xu, M; Zhao, J, 2022)
"Obesity is a major health crisis in the modern society."( Bao, L; Fang, Y; Li, P; Liang, F; Ni, W; Wang, B; Zhang, J, 2023)
"Obesity is a major health crisis in the modern society."( Bao, L; Fang, Y; Li, P; Liang, F; Ni, W; Wang, B; Zhang, J, 2023)
"Obesity is a major health crisis in the modern society."( Bao, L; Fang, Y; Li, P; Liang, F; Ni, W; Wang, B; Zhang, J, 2023)
"Obesity is generally associated with insulin resistance in liver and muscle and increased risk of developing type 2 diabetes, however there is a population of obese people that remain insulin sensitive."( Brandon, AE; Bruce, CR; Cooney, GJ; Gong, H; Hancock, SE; Kebede, MA; Kowalski, GM; Nguyen, TV; Prescott, L; Pulpitel, T; Quek, LE; Small, L; Stonehouse, S; Suryana, E; Turner, N; Yassmin, C; Yau, B, 2022)
"Obesity is generally associated with insulin resistance in liver and muscle and increased risk of developing type 2 diabetes, however there is a population of obese people that remain insulin sensitive."( Brandon, AE; Bruce, CR; Cooney, GJ; Gong, H; Hancock, SE; Kebede, MA; Kowalski, GM; Nguyen, TV; Prescott, L; Pulpitel, T; Quek, LE; Small, L; Stonehouse, S; Suryana, E; Turner, N; Yassmin, C; Yau, B, 2022)
"Obesity is generally associated with insulin resistance in liver and muscle and increased risk of developing type 2 diabetes, however there is a population of obese people that remain insulin sensitive."( Brandon, AE; Bruce, CR; Cooney, GJ; Gong, H; Hancock, SE; Kebede, MA; Kowalski, GM; Nguyen, TV; Prescott, L; Pulpitel, T; Quek, LE; Small, L; Stonehouse, S; Suryana, E; Turner, N; Yassmin, C; Yau, B, 2022)
"Obesity is characterized by excess fat accumulation and closely associated with insulin resistance and type 2 diabetes."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"Obesity is characterized by excess fat accumulation and closely associated with insulin resistance and type 2 diabetes."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"Obesity is characterized by excess fat accumulation and closely associated with insulin resistance and type 2 diabetes."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"Obesity is a chronic metabolic disease caused by a combination of genetic and environmental factors."( Chen, S; Chen, X; Li, Z; Niu, S; Pan, X; Ren, Q; Yue, L, 2022)
"Obesity is a chronic metabolic disease caused by a combination of genetic and environmental factors."( Chen, S; Chen, X; Li, Z; Niu, S; Pan, X; Ren, Q; Yue, L, 2022)
"Obesity is a chronic metabolic disease caused by a combination of genetic and environmental factors."( Chen, S; Chen, X; Li, Z; Niu, S; Pan, X; Ren, Q; Yue, L, 2022)
"Obesity is the leading risk factor for developing metabolic (dysfunction)-associated fatty liver disease (MAFLD)."( Aubourg, SP; Barriga, A; Dovale-Rosabal, G; Espinosa, A; Palomino-Calderón, A; Rodríguez, A; Romero, N; Troncoso, RH, 2022)
"Obesity is the leading risk factor for developing metabolic (dysfunction)-associated fatty liver disease (MAFLD)."( Aubourg, SP; Barriga, A; Dovale-Rosabal, G; Espinosa, A; Palomino-Calderón, A; Rodríguez, A; Romero, N; Troncoso, RH, 2022)
"Obesity is the leading risk factor for developing metabolic (dysfunction)-associated fatty liver disease (MAFLD)."( Aubourg, SP; Barriga, A; Dovale-Rosabal, G; Espinosa, A; Palomino-Calderón, A; Rodríguez, A; Romero, N; Troncoso, RH, 2022)
"Obesity is associated with an imbalance of micro-and macro-nutrients, gut dysbiosis, and a "leaky" gut phenomenon."( Albracht-Schulte, K; Islam, T; Kalupahana, NS; Moustaid-Moussa, N; Park, OH; Ramalingam, L; Schlabritz-Lutsevich, N; Zabet-Moghaddam, M, 2023)
"Obesity is associated with an imbalance of micro-and macro-nutrients, gut dysbiosis, and a "leaky" gut phenomenon."( Albracht-Schulte, K; Islam, T; Kalupahana, NS; Moustaid-Moussa, N; Park, OH; Ramalingam, L; Schlabritz-Lutsevich, N; Zabet-Moghaddam, M, 2023)
"Obesity is a metabolic disease which promotes by consuming fat rich diet."( Arshad, M; Farhan, M; Rafi, H; Rafiq, H; Rehman, S, 2022)
"Obesity is a metabolic disease which promotes by consuming fat rich diet."( Arshad, M; Farhan, M; Rafi, H; Rafiq, H; Rehman, S, 2022)
"Obesity is associated with the release of inflammatory mediators from adipose tissue, known as adipocytokines, causing a chronic inflammatory state."( Antonakos, N; de Nooijer, AH; Giamarellos-Bourboulis, EJ; Grondman, I; Kox, M; Markopoulou, D; Netea, MG; Pickkers, P, 2023)
"Obesity is associated with the release of inflammatory mediators from adipose tissue, known as adipocytokines, causing a chronic inflammatory state."( Antonakos, N; de Nooijer, AH; Giamarellos-Bourboulis, EJ; Grondman, I; Kox, M; Markopoulou, D; Netea, MG; Pickkers, P, 2023)
"Obesity is a major global public health concern, limiting socio-economic development and human productivity."( Adams, ZS; Asante-Donyinah, D; Dzah, CS; Dzikunoo, J; Letsyo, E, 2023)
"Obesity is a major global public health concern, limiting socio-economic development and human productivity."( Adams, ZS; Asante-Donyinah, D; Dzah, CS; Dzikunoo, J; Letsyo, E, 2023)
"The prevalence of obesity is rising, creating an urgent need for efficacious therapies."( Boer, GA; Hay, DL; Tups, A, 2023)
"The prevalence of obesity is rising, creating an urgent need for efficacious therapies."( Boer, GA; Hay, DL; Tups, A, 2023)
"Obesity is the result of the long-term energy imbalance between the excess calories consumed and the few calories expended."( Bertoncini-Silva, C; Fassini, PG; Suen, VMM; Zingg, JM, 2023)
"Obesity is the result of the long-term energy imbalance between the excess calories consumed and the few calories expended."( Bertoncini-Silva, C; Fassini, PG; Suen, VMM; Zingg, JM, 2023)
"Obesity is a worldwide epidemic associated with many health problems."( Al-Thepyani, M; Algarni, S; Baz, L; Elzubier, M; Gashlan, H, 2022)
"Obesity is a worldwide epidemic associated with many health problems."( Al-Thepyani, M; Algarni, S; Baz, L; Elzubier, M; Gashlan, H, 2022)
"The prevalence of obesity is increasing worldwide, and obesity can cause type 2 diabetes, atherosclerosis, hypertension, cardiovascular disease, and cancer."( Abe, T, 2022)
"The prevalence of obesity is increasing worldwide, and obesity can cause type 2 diabetes, atherosclerosis, hypertension, cardiovascular disease, and cancer."( Abe, T, 2022)
"Obesity is a major complication in children with 21-hydroxylase deficiency (21-OHD)."( Etani, Y; Hata, A; Ida, S; Kawai, M; Maeyama, T; Nishigaki, S; Wada, T, 2023)
"Obesity is a major complication in children with 21-hydroxylase deficiency (21-OHD)."( Etani, Y; Hata, A; Ida, S; Kawai, M; Maeyama, T; Nishigaki, S; Wada, T, 2023)
"Obesity is associated with severe, difficult-to-control asthma, and increased airway oxidative stress."( Aliyeva, M; Anathy, V; Bruno, SR; Butzirus, IM; Caffry, S; Chamberlain, N; Chandrasekaran, R; Daphtary, N; Dixon, AE; Gold, C; Janssen-Heininger, Y; Kumar, A; Lam, YW; Mark, ZF; Morris, CR; Poynter, ME; van der Vliet, A; Walzer, J, 2023)
"Obesity is associated with severe, difficult-to-control asthma, and increased airway oxidative stress."( Aliyeva, M; Anathy, V; Bruno, SR; Butzirus, IM; Caffry, S; Chamberlain, N; Chandrasekaran, R; Daphtary, N; Dixon, AE; Gold, C; Janssen-Heininger, Y; Kumar, A; Lam, YW; Mark, ZF; Morris, CR; Poynter, ME; van der Vliet, A; Walzer, J, 2023)
"Obesity is common in highland areas owing to lifestyle alterations."( Hu, C; Liu, F; Wang, S; Wei, Y, 2022)
"Obesity is the main risk factor for the increased occurrence of metabolic alterations as well as mood disorders."( Annunziata, C; Comella, F; Del Piano, F; Ferrante, MC; Grumetto, L; Lama, A; Mattace Raso, G; Meli, R; Melini, S; Opallo, N; Pirozzi, C, 2023)
"In today's society, obesity is becoming increasingly serious, and controlling food intake and maintaining weight balance have become increasingly important."( Chen, L; Feng, X; Gao, P; Jiang, Q; Li, Y; Liang, J; Mo, Y; Shu, G; Sun, Z; Wang, L; Wang, S; Wu, X; Xie, K; Zhu, C; Zhu, S; Zhu, X, 2023)
"Obesity is a global epidemic, it can induce glucose and lipid metabolism disorder and non-alcoholic fatty liver disease (NAFLD)."( Chen, CL; Chen, Y; He, Q; Li, YH; Qin, LQ; Wu, JX; Wu, YH; Xu, JY; Zhang, Z; Zhou, Y, 2023)
"Obesity is associated with an increased risk of developing type 2 diabetes mellitus (T2DM) and end-stage renal disease (ESRD)."( Cho, YK; Han, KD; Huh, JH; Ihm, SH; Kang, JG; Kim, YH; Kim, YJ; Lee, SJ; Moon, S, 2023)
"Obesity is a major risk factor for developing various health problems, including insulin resistance and type 2 diabetes."( Ayoub, MB; Bergeron, R; Dulac, M; Gouspillou, G; Hussain, SNA; Leduc-Gaudet, JP; Mayaki, D; Reynaud, O; Wang, J, 2023)
"Obesity is a medical term used to describe an over-accumulation of adipose tissue."( Cho, KH; Cho, ML; Choi, J; Jhun, J; Jung, YJ; Kim, SY; Min, JK; Moon, J; Na, HS; Song, KY, 2022)
"Obesity is associated with impaired learning, but the mechanisms underlying this cognitive dysfunction are poorly understood."( Bolaños-Jiménez, F; Croyal, M; García Santillán, JA; Gourdel, M; Mezo-González, CE; Reyes-Castro, LA, 2023)
"Obesity is a major health concern for breast cancer survivors, being associated with high recurrence and reduced efficacy during cancer treatment."( Bellerba, F; Bonanni, B; Chatziioannou, AC; Gandini, S; Hartman, SJ; Jasbi, P; Johansson, H; Keski-Rahkonen, P; Robinot, N; Scalbert, A; Sears, DD; Trolat, A; Vozar, B, 2022)
"Obesity is associated with multiple comorbidities, such as metabolic abnormalities and cognitive dysfunction."( Chen, SC; Cheng, PC; Clair Chiou, HY; Hsiao, PJ; Huang, SK; Hung, CH; Kuo, CH; Lin, MH, 2023)
"However, obesity is also associated with development of an autoimmune response against various organs, including pancreatic beta cells."( Chylińska-Frątczak, A; Michalak, A; Pietrzak, I; Szadkowska, A; Wyka, K, 2022)
"Obesity is a serious problem among Saudis because of the country's affluent lifestyle."( Abujamel, TS; Alamri, T; Alkhaldy, AA; Azhar, EI; Barnawi, S; Gauthaman, K; Harakeh, S; Karamitros, T; Mirza, AA; Moulay, M; Papadopoulou, G; Pushparaj, PN, 2022)
"Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health."( Brierley, DI; Chianese, R; Cristiano, C; Dowsett, GKC; Gribble, FM; Heisler, LK; Jiang, W; Lam, BYH; Leeson-Payne, A; Lyons, D; Martinez de Morentin, PB; Reimann, F; Trapp, S; Wagner, S; Yeo, GSH, 2023)
"Obesity is an ongoing epidemic that influences pathobiology in numerous disease states."( Alder, MN; Bodilly, L; Howell, K; Kaplan, JM; Williamson, L, 2023)
"Asthma and obesity are considered as highly prevalent diseases with a great impact on public health."( Gómez-Bastero, A; Jiménez-Cortegana, C; Novalbos-Ruiz, JP; Sánchez-Margalet, V; Sánchez-Ortega, H; Soto-Campos, JG, 2022)
"Obesity is considered an independent risk factor for colorectal cancer (CRC)."( Castellanos, K; Fitzgibbon, M; Gaskins, HR; Hamm, A; Loman, BR; McLeod, A; Olender, S; Oliveira, ML; Penalver Bernabe, B; Tussing-Humphreys, L; Wolf, PG, 2023)
"Obesity is a state of accumulating excessive body fat, charactering by a high blood lipid and associating with various metabolic diseases."( Ni, W; Teng, C; Wu, Z; Ye, W; Yu, C; Yu, W; Zeng, Y, 2023)
"Obesity is associated with adverse effects on brain health, including an increased risk of neurodegenerative diseases."( Bottari, SA; Britton, MK; Chen, A; Cohen, RA; Friedman, J; Gunstad, J; Porges, EC; Williamson, JB; Woods, AJ, 2023)
"Obesity is a major global health problem that significantly increases the risk of many other diseases."( Deng, C; Li, L; Li, Q; Liu, E; Liu, Y; Qu, S; Tang, Z; Wang, B; Wang, L; Wu, J; Xing, G; Zhang, B; Zhang, H, 2023)
"Obesity is an established risk factor for cardiometabolic disease."( Fu, W; Liu, Y; Wu, J; Yin, H; Yu, H; Zhang, S; Zhong, L; Zou, L, 2023)
"Obesity is associated with complex adipose tissue energy metabolism remodeling."( Andrade, S; Bernardino, RL; Costa, MM; Guimarães, M; Monteiro, MP; Nora, M; Oliveira, SB; Pereira, AM; Pereira, SS; Topete, MV, 2023)
"Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes."( Amato, A; Calvi, P; Castellino, G; Chianetta, R; Ciaccio, M; Firenze, A; Giglio, RV; Magán-Fernández, A; Mulè, F; Nikolic, D; Patti, AM; Rizzo, M; Terzo, S, 2023)
"Obesity is a chronic metabolic disease that involves excessive accumulation of fat in white adipose tissue (WAT)."( Agnihotri, N; Bhandari, C; Sharma, P, 2023)
"Obesity is a global health challenge."( Amaro, A; Sugimoto, D; Wharton, S, 2022)
"Obesity is an epidemic and a growing public health concern worldwide."( Chhimwal, J; Dadhich, G; Joshi, R; Katoch, S; Padwad, Y; Patial, V; Rana, A; Sharma, V, 2023)
"Obesity is a considerable health concern with limited pharmacotherapy options of low efficacy."( Chen, X; Dong, X; Guo, W; Jin, Y; Kharitonenkov, A; Zhai, P; Zhang, Y; Zhao, X; Zou, H, 2023)
"Obesity is a leading risk factor for chronic diseases, potentially related to excess abdominal adiposity."( Allison, M; Bao, W; Hankinson, SE; Manson, JE; Odegaard, AO; Oulhote, Y; Reeves, KW; Shadyab, AH; Thomson, CA; Tinker, L; Vandenberg, LN; Vieyra, G, 2023)
"Since obesity is associated with a state of chronic low-grade inflammation, one can anticipate that the lipidomic profile changes in this context and both PCs and LPCs are gaining attention as hypothetically reliable biomarkers of obesity."( Barbosa, F; Bellot, PENR; Moia, MN; Pedrosa, LFC; Reis, BZ; Sena-Evangelista, KCM; Tasic, L, 2023)
"Obesity is associated with the development of various complications, including diabetes, atherosclerosis, and an increased risk for infections, driven by dysfunctional innate immune responses."( Stienstra, R; Vrieling, F, 2023)
"Leptin-deficient obesity is associated with various systemic diseases including diabetes and low bone mass phenotype."( Cheng, H; Jaspers, RT; Li, H; Li, Z; Pathak, JL; Piao, Z; Wang, T; Wu, G; Wu, L; Xu, S; Zheng, Z, 2023)
"Obesity is associated with altered cortisol metabolism, but there is limited information on pregnancy-related changes in cortisol in pregnant women with overweight/obesity."( Hohman, EE; McNitt, KM; Pauley, AM; Savage, JS; Smyth, JM; Symons Downs, D, 2022)
"Obesity is one of the most important metabolic disorders of this century and is associated with a cluster of the most dangerous cardiovascular disease risk factors, such as insulin resistance and diabetes, dyslipidemia, and hypertension, collectively named Metabolic Syndrome."( da Silva, IV; Soveral, G, 2023)
"Obesity is one of the leading noncommunicable diseases in the world."( Araujo, EP; Carregari, VC; Catharino, RR; Delafiori, J; Gaspar, RS; Martins-de-Souza, D; Morari, J; Prado, TP; Sidarta-Oliveira, D; Solon, CS; Velloso, LA; Zuccoli, G, 2023)
"Obesity is a key autonomous risk factor for heart failure and contributes to cardiovascular disease (CVD) risk factors such as hypertension, type 2 diabetes, and metabolic abnormalities."( Ali, M; Kafle, A; Khatoon, N; Mallah, MA; Naveed, M; Noreen, S; Soomro, T, 2023)
"Obesity is a global pandemic and is cause of serious concern in all regions of the world."( Attanasio, R; Borretta, G; Busetto, L; Chianelli, M; Disoteo, OE; Grimaldi, F; Nicolucci, A; Paoletta, A; Papini, E; Persichetti, A; Samperi, I; Scoppola, A, 2022)
"Moreover, aging and obesity are also risk factors for ALD."( Chao, X; Ding, WX; Jiang, X; Li, Y; Ni, HM; Qian, H; Rülicke, T; Sun, Z; Wang, S; Zatloukal, K, 2023)
"Obesity is a life-threatening metabolic disorder that predisposes individuals to other diseases."( Al-Emarah, MK; Dehghani, H; Elahi, M; Kazerani, HR; Taghizad, F, 2023)
"Obesity is a complex disease highly related to diet and lifestyle and is associated with low amount of thermogenic adipocytes."( Amri, EZ; Balas, L; Batrow, PL; Bernoud-Hubac, N; Colson, C; Contu, L; Dieckmann, S; Durand, T; Fourmaux, B; Gautier, N; Klingenspor, M; Langin, D; Rochet, N; Roux, CH; Vigor, C, 2023)
"Obesity is associated with severe asthma, but no specific treatment has been established."( Kimura, S; Kurihara, Y; Sadamatsu, H; Sueoka-Aragane, N; Takahashi, K; Takamori, A; Tashiro, H; Uchida, M, 2023)
"Obesity is a serious health problem worldwide, since it is associated with multiple metabolic disorders and complications such as cardiovascular disease, type 2 diabetes, fatty liver disease and overall metabolic dysfunction."( Domínguez-Avila, JA; González-Aguilar, GA; López-Almada, G; Mejía-León, ME; Robles-Sánchez, M; Salazar-López, NJ, 2023)
"Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer's disease."( Fang, X; Ge, X; Geng, D; Guan, L; Hu, M; Huang, XF; Liu, S; Pan, W; Tang, R; Wang, L; Xie, Y; Yu, Y; Zhang, J; Zheng, K; Zheng, M; Zheng, P; Zhou, L; Zhou, M, 2023)
"Pet obesity is becoming increasingly common and may have a negative impact on pet health."( Dang, H; Huang, Y; Ren, Y; Shan, T; Wang, Y; Zhang, S, 2023)
"Obesity is a major risk factor for type 2 diabetes, coronary heart disease, and strok."( ALjohani, A; Assadi-Porter, F; Burhans, MS; Kalyesubula, M; Liu, X; Ntambi, JM; Selen, ES, 2023)
"Obesity is a global epidemic disease representing the fifth leading cause of death in the world."( Barakat, A; Bouafi, H; Charoute, H; Harmak, H; Krami, AM; Morjane, I; Saile, R; Slaoui, K, 2023)
"Obesity is a major risk factor for colorectal cancer (CRC)."( Abe, Y; Goto, H; Ito, M; Kon, T; Mizumoto, N; Nakamura, S; Onozato, Y; Sakai, T; Sasaki, Y; Ueno, Y; Umehara, M; Yagi, M, 2023)
"Obesity is an increasing problem that can lead to noncommunicable diseases."( Ghoddusi Johari, M; Hosseini, SV; Jalali, M; Keshani, P; Rezaeianzadeh, R; Rezaianzadeh, A, 2022)
"Obesity is one of the foremost public health concerns."( Cai, G; Deng, Y; Feng, S; Ge, G; Liu, P; Peng, S; Yang, J; Yang, S; Zhang, M, 2023)
"Obesity is linked to neurodegeneration, which is mainly caused by inflammation and oxidative stress."( Allegra, M; Amato, A; Calvi, P; Mulè, F; Nuzzo, D; Picone, P; Terzo, S, 2023)
"Obesity is a complex multifactorial disease characterized by excessive adiposity, and is linked to an increased risk of nonalcoholic fatty liver disease (NAFLD)."( Aboudeya, HM; Bakir, MB; Kamel, MA; Masoud, IM; Oriquat, G; Shaker, SA, 2023)
"Obesity is a complex disease characterized by excessive fat accumulation which is caused by genetic, environmental and other factors."( Jin, JY; Li, DR; Wang, JY; Wang, QW; Yang, W; Yang, XY; Zhang, HC; Zhang, XF, 2023)
"Obesity is a major health challenge worldwide, with implications for diabetes, hypertension and cardiovascular disease (CVD)."( Cacabelos, R; Carrera, I; Corzo, L; Martínez-Iglesias, O; Naidoo, V, 2023)
"Obesity is a systemic metabolic disease that can induce male infertility or subfertility through oxidative stress."( Ding, Z; Fan, W; Han, S; Jing, J; Liu, Y; Peng, Q; Peng, Y; Qin, X; Xue, C, 2023)
"Obesity is widely recognized as a major global health problem caused by a chronic energy imbalance resulting from a combination of excess caloric intake and insufficient energy expenditure."( He, LP; Li, CP; Zhou, ZX, 2023)
"The prevalence of obesity is on the rise and is connected to numerous factors."( Chu, SF; Fang, ZB; Feng, LY; Huang, BL; Li, HL; Li, JT; Liu, DL; Wang, GX; Zhao, HX, 2023)
"Obesity is a major public health problem worldwide, and it is associated with many diseases and abnormalities, most importantly, type 2 diabetes."( Bodis, B; Bognar, Z; Palfi, A; Ramadan, FHJ; Sandor, B; Szabados, E; Szekeres, Z; Toth, K, 2023)
"Obesity is increasing in all age groups and, consequently, its incidence has also risen in women of childbearing age."( Burlina, S; Dalfrà, MG; Lapolla, A, 2023)
"The occurrence of obesity is an increasing issue worldwide, especially in industrialized countries."( Armentaro, G; Arturi, F; Cassano, V; Giofrè, F; Pelle, MC; Sciacqua, A; Zaffina, I, 2023)
"Obesity is a classified epidemic, increasing the risk of secondary diseases such as diabetes, inflammation, cardiovascular disease, and cancer."( Haglund, E; Hu, Y; Kricek, F; Kurth, EA; Orellana, GE; Phan, HTN; Ruf, C; Simien, JM; Smrcka, AV; Wang, Q, 2023)
"Obesity is a chronic metabolic disease that is prevalent worldwide, causing complications that affect the quality of life and longevity of humans."( Jang, M; Juhng, S; Jung, H; Kang, G; Ko, HW; Park, J; Shin, J; Song, J; Yang, H; You, J, 2023)
"Obesity is a major risk factor for hyperglycemia, but the underlying mechanism is unknown."( Dietz, N; Fendt, SM; Frei, IC; Hall, MN; Hay, N; Maier, T; Meyer-Gerspach, AC; Peterli, R; Planque, M; Ritz, D; Rohner, N; Shetty, S; Shimobayashi, M; Thomas, A; Vandekeere, A; Weissenberger, D; Wölnerhanssen, BK, 2023)
"Obesity is a dramatically increasing disease, accompanied with comorbidities such as cardiovascular disease and obstructive sleep apnea syndrome (OSAS)."( Bruchhage, KL; Lange, C; Marquardt, JU; Meyhöfer, S; Meyhöfer, SM; Plötze-Martin, K; Pries, R; Steffen, A, 2023)
"Obesity is recognized as a major healthcare challenge."( Flatt, PR; Irwin, N; Lafferty, RA, 2023)
"Obesity is a major contributing factor for metabolic-associated fatty liver disease (MAFLD)."( Chen, C; Gao, D; Li, X; Wang, J; Yang, L; Yang, W; Yu, C; Zhang, F; Zhang, JS, 2023)
"Obesity is a major health problem because it is associated with increased risk of cardiovascular disease, diabetes, hypertension, and some cancers."( Ali, U; Colitti, M; Tews, D; Wabitsch, M, 2023)
"Obesity is characterized by systemic low-grade inflammation associated with disturbances of intestinal homeostasis and microbiota dysbiosis."( Andriamihaja, M; Beaumont, M; Boudry, G; Ciesielski, V; Guerbette, T; Janvier, R; Lan, A; Leroyer, P; Loréal, O; Perrin, JB; Randuineau, G; Rioux, V, 2023)
"Uncorrected obesity is accompanied by unfavorable structural and functional changes in the heart, known as obesity cardiomyopathy."( Bi, Y; Ge, J; Ren, J; Sun, M; Wu, NN; Xu, H; Yang, Q; Yu, W; Zhang, M; Zhang, Y; Zhou, Y, 2023)
"Obesity is a negative prognosis factor for breast cancer."( Arellano, C; Attané, C; Bouche, C; Dauvillier, S; Fallone, F; Muller, C; Rebeaud, M; Vaysse, C, 2023)
"Obesity is a chronic and recurrent metabolic disease associated with serious complications and increased mortality."( Chartoumpekis, D; Favre, L, 2023)
"Patients with obesity are at risk for nutritional deficiencies because of poor-quality diets and the chronic inflammatory state of obesity."( Connors, A; Watkins, EJ, 2023)
"Obesity is a metabolic disorder resulting from behavioral, environmental and heritable causes, and can have a negative impact on male reproduction."( Cao, W; Hu, H; Li, M; Liu, E; Qi, J; Qin, H; Qu, P; Wei, L; Zhang, Y; Zhao, J; Zhou, K, 2023)
"Because obesity is associated with impaired glucose tolerance and type 2 diabetes (T2D), it is important to manage the blood glucose level at an early stage."( Isobe, T; Kim, M; Kim, T; Mori, Y; Oh, S; Okura, T; Sakae, T; Tanaka, K; Zhang, H, 2023)
"Obesity is a substantial health and economic issue, and serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter system involved in the regulation of body weight."( Filip, M; Kotlińska, JH; Przegaliński, E; Witek, K; Wydra, K, 2023)
"Obesity is a serious health issue."( Hassanin, HM; Ismail, OI, 2023)
"Obesity is an important independent risk factor for hypertension, and few studies have assessed the interaction between obesity and metals in this context."( Chen, Q; Dong, M; Huang, H; Ji, G; Li, J; Li, L; Liu, T; Ma, A; Ma, W; Wei, Y; Wu, B; Wu, S; Xing, X; Zhao, D, 2023)
"Obesity is associated with alterations in brain structure and function, particularly in areas related to reward processing."( Arolt, V; Bauer, J; Dannlowski, U; Dohm, K; Enneking, V; Goltermann, J; Grotegerd, D; Kraus, A; Kugel, H; Leehr, EJ; Malz, F; Meinert, S; Opel, N; Redlich, R; Repple, J; Richter, M; Steinmann, L; Widera, S, 2023)
"Pregnant women with obesity are more likely to deliver infants who are large for gestational age (LGA)."( Dumolt, JH; Horwitz, S; Jansson, T; Kramer, AC; Powell, TL; Rosario, FJ, 2023)
"Obesity is a metabolic disorder associated with many diseases."( Higami, Y; Hoshino, S; Kobayashi, M; Nozaki, Y; Ose, Y; Suwa, F; Tagawa, R; Wakasawa, H, 2023)
"Obesity is linked with heightened cardiovascular risk, especially when accompanied by metabolic abnormalities."( Campia, U; Cardillo, C; Schinzari, F; Tesauro, M; Vizioli, G, 2023)
"As diabetes and obesity are major risk factors for HF, earlier consideration of, and diagnosis of HF, followed by guideline-directed medical therapy can meaningfully improve patients' lives."( Lee, MMY; Sattar, N, 2023)
"Obesity is linked to cardiometabolic diseases, however non-obese individuals are also at risk for type 2 diabetes (T2D) and cardiovascular disease (CVD)."( Andersson, DP; Arner, P; Hofwimmer, K; Laurencikiene, J; Massier, L; Subramanian, N; Tavira, B, 2023)
"Excess weight and obesity are the fifth leading cause of death globally, and sustained efforts from health professionals and researchers are required to mitigate this pandemic-scale problem."( Auxenfans, C; Berthon, JY; Boutin, R; Caldefie-Chezet, F; Chervet, A; Decombat, C; Delort, L; Diab-Assaf, M; Filaire, E; Fraisse, D; Guyon, JB; Longechamp, L; Nehme, R; Rossary, A; Rousset, A; Senejoux, F; Vachias, C, 2023)
"Obesity is a global threat for male infertility, which can cause spermatogenic dysfunction."( Huang, H; Ji, L; Lei, X; Luo, M; Mo, Y; Tan, Y; Wang, J; Zhou, L; Zhuge, X, 2023)
"Obesity is associated with derangement of cardiac metabolism and the development of subclinical cardiovascular disease."( Abel, ED; Aminian, A; Butsch, WS; Chen, S; Das, S; Eder, RA; Farrar, CT; Garrett, T; Gee, D; Nguyen, CT; Tang, WHW; Yurista, SR, 2023)
"obesity is a major risk factor for many metabolic diseases such as diabetes and cardiometabolic diseases."( Cai, J; Gou, R; Huang, S; Lin, Y; Liu, Q; Liu, S; Lu, Y; Luo, T; Mai, T; Mo, X; Qin, J; Qin, L; Tang, X; Wei, C; Wei, Y; Xu, M; Zhang, J; Zhang, Z, 2023)
"Obesity is a worldwide epidemic leading to decreased quality of life, higher medical expenses and significant morbidity."( Bhunia, RK; Bishnoi, M; Kaur, J; Kaur, S; Kondepudi, KK; Kuhad, A; Kumar, V; Singh, DP, 2023)
"Obesity is linked to the development of major metabolic disorders such as type 2 diabetes, cardiovascular disease, and cancer."( , 2023)
"Obesity is a chronic disease characterised by excess adiposity, which impairs health."( Abdul Wahab, R; Cohen, RV; le Roux, CW, 2023)
"Obesity is an immoderate or abnormal accretion of fat or adipose tissue in the body that is prone to damage the health of mankind."( Danda, AK; Kotakadi, SM; Mohammed, RA; Nannepaga, JS, 2023)
"Obesity is currently a prerequisite for more than 70% of adults, including chronic obesity and long-term obesity."( Lu, B; Wu, C; Zhang, J, 2023)
"While obesity is a well-known health threatening condition worldwide, effective pharmacological interventions for obesity suppression have been limited due to adverse effects."( Boonmuen, N; Chairoungdua, A; Kaewkittikhun, M; Ruknarong, L; Saeeng, R; Silalai, P; Soodvilai, S; Suksen, K; Tantikanlayaporn, D, 2023)
"Obesity is a global public health problem with rapidly increasing prevalence in many countries, including Turkey, and different treatment modalities have been used."( Altunal, Ç; Cengiz, M; Sadıkoğlu, T; Sahiner, IT; Yavuzer, S, 2023)
"Obesity is a growing global health concern."( Priyadarshini, P; Rai, C, 2023)
"Obesity is associated with increased mortality among ovarian cancer and is a poor prognostic factor."( Akman, L; Atmaca, H; Dincer, F; Karaca, B; Oktay, LM; Terek, MC, 2023)
"Patients with obesity are more susceptible to hypoxemia."( Fan, G; Li, Y; Liang, W; Ma, Q; Meng, F; Qin, W; Ren, Z; Wang, Y; Yin, N; Zhang, X; Zheng, L, 2023)
"Obesity is characterized by the excessive accumulation of fat, which triggers a low-grade chronic inflammatory process."( Barrios-Nolasco, A; Cornejo-Garrido, J; Domínguez-López, A; Jaramillo-Flores, ME; Miliar-García, A, 2023)
"Obesity is associated with unique clinical and disease-related phenotypic features in AML and may influence physician treatment decisions regarding daunorubicin dosing."( Bennett, JM; Cripe, LD; Fernandez, HF; Foran, JM; Ketterling, RP; Lai, C; Lazarus, HM; Levine, RL; Litzow, MR; Luger, SM; Paietta, E; Racevskis, J; Rowe, JM; Sun, Z; Tallman, MS; Zhang, Y, 2023)
"Obesity is a global health problem strongly linked to gut microbes and their metabolites."( Chang, SY; Han, SZ; Jin, ZY; Kang, JD; Li, D; Liu, H; Liu, Y; Luo, ZB; Quan, LH; Wang, D; Wang, JX; Yang, LH; Zhu, J, 2023)
"Obesity is a systemic disease with multisystem inflammation associated with gut dysbiosis."( Cai, J; Cao, Y; Dong, X; Fan, P; Liu, J; Tai, J; Zhang, N, 2023)
"Obesity is prevalent in rural areas of China, and there are inconsistent findings regarding the association between metal(loid) exposure and the risk of obesity."( Chen, XC; Dong, CY; Dong, GH; Gong, YC; Hao, CJ; Kuang, HX; Li, ZC; Tian, JL; Wu, QZ; Xiang, MD; Yang, X; Yu, YJ; Zhou, Y, 2023)
"Obesity is thought to negatively impact bone quality and strength despite improving bone mineral density."( Bloomfield, SA; Breidenbach, BM; Elizondo, JP; Hogan, HA; Letsinger, AC; Lightfoot, JT; Little-Letsinger, SE, 2023)
"One cause of obesity is excess exposure to the saturated fatty acid palmitate that can alter miRNA levels in the periphery."( Belsham, DD; McIlwraith, EK, 2023)
"Obesity is a global epidemic that affects people of all ages, genders, and backgrounds."( Buttar, HS; Kaur, G; Kothawade, SM; Tuli, HS, 2023)
"Obesity is positively correlated with the aggravation of periodontitis."( Hu, B; Jia, R; Qiao, H; Wang, Z; Zhang, Y, 2023)
"Obesity is of public concern worldwide, and it increases the probability of developing a number of comorbid diseases, including NAFLD."( Li, Y; Liu, S; Pan, T; Qi, X; Su, S; Sun, M; Zhou, L, 2023)
"Obesity is characterized by immoderate fat accumulation leading to an elevated risk of neurodegenerative disorders, along with a host of metabolic disturbances."( Alberts, T; Behrangi, N; Bergner, C; Bühler, D; Janowitz, D; Krause, BJ; Kuhla, A; Kurth, J; Lindner, T; Müller, L; Power Guerra, N; Schildt, A; Stenzel, J; Teipel, S; Vollmar, B, 2023)
"Obesity is a major global public health concern associated with an increased risk of many health problems, including type 2 diabetes, heart disease, stroke, and some types of cancer."( Ahn, B, 2023)
"Obesity is associated with the presence of low-grade inflammation even during childhood."( de Dios, O; Garcés, C; Gavela-Pérez, T; Pérez-Nadador, I; Soriano-Guillén, L; Vales-Villamarín, C, 2023)
"Obesity is one of the risk factors for gallstone disease (GD)."( Kumar, R; Srivastava, S, 2023)
"Obesity is primarily a consequence of food addiction."( Gu, R; Hao, H; Jia, J; Kang, L; Li, Z; Qi, Y; Qiao, S; Sun, X; Wang, K; Xu, B; Zhang, Q; Zhang, X, 2023)
"Obesity is strongly related to the risk of CKD, progression of CKD, and end-stage renal disease (ESRD), also after adjustment for age, sex, race, smoking status, comorbidities, and laboratory tests."( Bevc, S; Ekart, R; Hojs, R; Vodošek Hojs, N, 2023)
"Obesity is characterized by the accumulation of adipose tissue in different body compartments."( Bamberg, F; Lorbeer, R; Mueller-Peltzer, K; Mujaj, B; Peters, A; Rospleszcz, S; Schlett, CL; Schulz, H; von Krüchten, R, 2023)
"Overweight/obesity is associated with an elevated reward region response to palatable food cues and food receipt."( Stice, E; Yokum, S, 2023)
"Obesity is well-established as a common comorbidity in ischemic stroke."( Govitrapong, P; Sengking, J; Tocharus, C; Tocharus, J; Yawoot, N, 2023)
"Obesity is currently regarded as a global concern, and the key objectives of the global health strategy include its prevention and control."( Bae, JM; Bae, MJ; Cho, HR; Kim, HH; Kim, SH; Kim, TH; Mahoro, P; Shin, YJ, 2023)
"Obesity is associated with high risk of mortality globally because obesity is associated with development of diseases such as diabetes, dyslipidemia, fatty liver disease, hypertension, and cancer."( Beak, JK; Choi, HJ; Choi, JW; Jeong, JB; Koh, EJ; Lee, JW; Ryu, GH, 2023)
"Monogenic obesity is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early-onset obesity."( Al Azwani, I; Al-Barazenji, T; Al-Shafai, M; Chirayath, S; Dauleh, H; Haris, B; Hussain, K; Khalifa, A; Love, DR; Mohamadsalih, G; Mohammed, I; Petrovski, G; Shehzad, S; Tomei, S; Vasudeva, D, 2023)
"Obesity is the number one cardiovascular risk factor for both men and women and is a complex condition."( Alves, JV; Awata, WMC; Barbosa, GS; Bruder-Nascimento, A; Bruder-Nascimento, T; Corrêa, CR; Costa, RM; Singh, S, 2023)
"Obesity is a risk factor for colorectal cancer (CRC)."( Kang, X; Kwong, TNY; Lam, TYT; Lin, Y; Liu, C; Ng, SK; Ni, Y; Sung, JJY; Wei, H; Wong, SH; Wu, WKK; Yu, J; Zhou, Y, 2023)
"Obesity is a major cause of infertility in females with a direct correlation between energy intake and reproductive dysfunction."( Flatt, PR; Khan, D; Moffett, RC; Sridhar, A, 2023)
"Obesity is a major risk factor for many leading causes of illness and death worldwide."( Blevins, T; Connery, L; Haupt, A; Kazda, C; Konig, M; Liu, R; Ma, X; Mather, KJ; Pratt, E; Raha, S; Robins, D; Rosenstock, J; Wharton, S, 2023)
"Human obesity is related with intrinsic impairments of adipocyte lipolysis and ectopic lipid accumulation."( Cai, J; Guo, X; Peng, Z; Xu, S, 2023)
"Postmenopausal obesity is a rising problem."( Chien, YW; Hsu, LW, 2023)
"Obesity is characterized by chronic inflammation that may contribute to insulin resistance and promote type 2 diabetes."( Eriksson, JW; Lundqvist, MH; Pereira, MJ, 2023)
"Obesity is recognized as a true chronic disease and an independent risk factor for kidney disease."( Amatuzio, A; Baranello, S; Buondonno, A; Corvinelli, M; De Stefano, F; Di Cienzo, G; Nazzaro, P; Principe, F; Trucillo, P; Vitagliano, C, 2023)
"Obesity is considered one of the independent risk factors for atherosclerosis and is strongly correlated with cardiovascular morbidity and mortality."( Ahmadyar, S; Dalili, A; Esparham, A; Khorgami, Z; Nelson, PR; Roohi, S, 2023)
"The prevalence of obesity is increasing, and the origins of obesity and metabolic dysfunction may be traced back to fetal life."( Duvald, CS; Greibe, E; Hoffmann-Lücke, E; Leth-Møller, M; Ovesen, PG; Pedersen, M; Stampe, S, 2023)
"Obesity is considered a risk factor for type 2 diabetes mellitus, which has become one of the most important health problems, and is also linked with memory and executive function decline."( Blecharz-Klin, K; Mirowska-Guzel, D; Piechal, A; Pyrzanowska, J; Strosznajder, RP; Wencel, PL, 2023)
"Abdominal obesity is the strongest risk factor for type 2 diabetes in lean nonalcoholic fatty liver disease."( Chang, M; Li, D; Li, N; Tan, H; Wu, S; Xang, W; Xie, C; Zhang, MY, 2023)
"Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern."( Cavalu, S; Metwally, K; Păduraru, L; Popoviciu, MS; Yahya, G, 2023)
"Obesity is a chronic disease with a high prevalence rate and is an established risk factor for human health."( Lv, C; Ma, N; Wan, B; Zhou, Z, 2023)
"Obesity is shown to be involved in TNBC tumor progression."( Cai, Y; Li, C; Liu, M; Lv, W; Qu, J; Sun, S; Wang, W; Wu, F; Zhang, S; Zhang, Y; Zhao, F; Zhao, X; Zhao, Z, 2023)
"Paternal obesity is an independent risk factor for developing obesity and type 2 diabetes in the following generation, and growing evidence suggests epigenetic inheritance as a mechanism for this predisposition."( Bak, ST; Dudele, A; Haupt-Jorgensen, M; Lund, S; Nielsen, AL; Wang, T; Wegener, G, 2023)
"Obesity is defined as a dampness-heat syndrome in traditional Chinese medicine."( Shaw, PC; Shou, JW, 2023)
"Obesity is considered to be a pandemic health problem globally, affecting millions of people worldwide."( Ajabnoor, GMA, 2023)
"Obesity is a chronic disease associated with increased morbidity and mortality."( Melson, E; Miras, AD; Papamargaritis, D, 2023)
"Obesity is a multifaceted disease characterized by an abnormal accumulation of adipose tissue."( Amiri, P; Hosseini, SA; Roshanravan, N; Saghafi-Asl, M; Tootoonchian, M, 2023)
"Obesity is a global health problem caused by genetic, environmental, and psychological factors and is associated with various health disorders."( Aihara, N; Kamiie, J; Mishima, M; Mizugaki, H; Nagane, M; Ogata, M; Okamatsu-Ogura, Y; Satoh, T; Shima, A; Suzuki, R; Suzuki, T; Takeda, S; Yamashita, T, 2023)
"Obesity is associated with improved survival in COPD patients highly adherent to NIV."( Adam, V; Bourbeau, J; Cherian, M; Kaminska, M; Ross, B, 2023)
"Obesity is a major risk factor for a variety of diseases and contributes to chronic inflammation."( Baek, SH; Kim, JS; Monmai, C, 2023)
"Although obesity is associated with hyperuricemia, data on sex differences in this association are scarce."( Chen, SC; Huang, JC; Lin, TH; Liu, YH; Su, HM; Su, SY; Wu, PY, 2023)
"Obesity is an important independent risk factor for T2DM, and excessive amino acids can convert into glucose and lipids, which might underlie the associations of amino acids with obesity."( Guo, Z; Li, Y; Liang, Y; Liu, Y; Qu, L; Sun, G; Wang, H; Wang, Y; Zhang, C, 2023)
"Obesity is associated with increased intestinal permeability and a diminished immune response."( Azarcoya-Barrera, J; Field, CJ; Jacobs, RL; Makarowski, A; Nelson, R; Richard, C; Rusnak, T; Wollin, B, 2023)
"Obesity is a global epidemic and risk factor for the development of chronic kidney disease."( Falk, RJ; Li, Y; Schroder, M; Sumner, S; Zeitler, EM, 2023)
"Obesity is considered one of the most crucial health problems of the century."( Macit Celebi, MS; Uner, B, 2023)
"Obesity is a metabolic disorder that results from an imbalance of energy intake and consumption."( Bae, YS; Kang, JH; Kim, HS; Kim, YS; Park, SH, 2023)
"Obesity is significantly associated with a reduction in SCFA concentration, microbial diversity, and SCFA synthesizing bacteria, with country of origin being the strongest explanatory factor."( Bedu-Addo, K; Bovet, P; Choo-Kang, C; Donato, S; Dugas, LR; Ecklu-Mensah, G; Forrester, TE; Gilbert, JA; Lambert, EV; Layden, BT; Luke, A; Maseng, MG; O'Keefe, S; Oti Boateng, P; Plange-Rhule, J; Rae, D; Sinyanya, N; Viswanathan, B; Williams, M, 2023)
"Obesity is a complex condition and the mechanisms involved in weight gain and loss are not fully understood."( Achaibou, A; Cereghetti, D; Coppin, G; Erdemli, A; Golay, A; León Pérez, L; Locatelli, L; Muñoz Tord, D; Pataky, Z; Pool, ER; Sander, D; Wuensch, L, 2023)
"Obesity is a prevalent chronic disorder and a well-known risk factor for cardiovascular disease."( Cercato, C; de Melo, ME; Mancini, MC; Santos, RD; Stumpf, MAM, 2023)
"Overweight and obesity are related to an increased risk of asthma."( Wang, N; Xu, S; Yan, D; Zhong, Y, 2023)
"Obesity is a chronic disease affecting over 670 million adults globally, with multiple complications including obstructive sleep apnea (OSA)."( Chapman, JL; Grunstein, RR; Malhotra, A; Phillips, CL; Wadden, TA, 2023)
"Sarcopenic obesity is characterized by concurrent obesity and muscle wasting (sarcopenia) and is common in the elderly."( Jin, H; Lee, BY; Oh, HJ, 2023)
"Sarcopenic obesity is associated with insulin resistance, inflammation, hormonal changes, and reduced physical activity."( Go, GW; Kang, S; Ki, SW; Kim, H; Kim, YC, 2023)
"Obesity is a popular public health problem worldwide and is mainly caused by overeating, but little is known about the impacts of synthetic chemicals on obesity."( Deng, Y; Yang, R; Yang, Y; Zhang, Y; Zhong, W; Zhu, L, 2023)
"Obesity is a metabolic disorder distinguished by excess fat deposition in fatty tissues."( Ananda K, C; Anwar, S; Chandolu, S; Jandrajupalli, SB; Khalifa, NE; Khojali, WMA; M Younes, K; Osman, ME; S Abouzied, A; Unnisa, A, 2023)
"Obesity is a non-communicable chronic disease that continues to increase around the world."( Büyükuslu, N; Cumbul, A; Dumlu Bilgin, G; Eyüpoğlu, OE, 2023)
"Obesity is a complicated disease characterized by abundant fat accumulation."( Abdelmottaleb Moussa, SA; Abdelrahman, SS; Bashandy, SAE; El-Seidy, AMA; ElBaset, MA; Ibrahim, FAA, 2023)
"Obesity is a major cause of morbidity and mortality globally, increasing the risk for chronic diseases."( Jack, BU; Mazibuko-Mbeje, SE; Moetlediwa, MT; Pheiffer, C; Ramashia, R; Titinchi, SJJ, 2023)
"Overweight and obesity are highly prevalent worldwide and are associated with cardiovascular disease (CVD) risk factors, including systematic inflammation, dyslipidemia, and hypertension."( Liao, W; Lu, Y; Sun, G; Sun, J; Wang, Y; Xia, J; Xu, D; Xu, H; Yin, S, 2023)
"Obesity is currently one of the most serious public health problems which affects up to 30-40% of the population, and its prevalence is higher in men than in women."( Rabijewski, M, 2023)
"Obesity is an independent risk factor for cardiovascular disease development."( Chen, C; Chu, C; Du, MF; Gao, K; Gao, WH; Hu, GL; Jia, H; Li, H; Liao, YY; Luo, WJ; Ma, Q; Man, ZY; Mu, JJ; Niu, ZJ; Sun, Y; Wang, D; Wang, KK; Wang, L; Wang, Y; Wu, GJ; Yan, Y; Zhang, J; Zhang, X; Zhang, XY, 2023)
"Obesity is linked to reduced fertility in various species, from Drosophila to humans."( Drummond-Barbosa, D; Nunes, RD, 2023)
"Obesity is associated with an increased risk of sleep-disordered breathing (SDB) and postoperative pulmonary complications (PPCs)."( Chen, Q; Li, R; Liu, L; Wei, K; Zeng, J; Zheng, X, 2023)
"Obesity is a state of metabolic dysfunction that can lead to dyslipidemia and impaired glucose homeostasis."( Kienesberger, PC; Pulinilkunnil, T; Rupasinghe, HPV; Yu, CHJ, 2023)
"Obesity is characterized by the expansion of the adipose tissue, usually accompanied by inflammation, with a prominent role of macrophages infiltrating the visceral adipose tissue (VAT)."( Beckervordersandforth, R; Bosserhoff, A; Bozec, A; Buechler, C; Dietrich, P; Ehnis, H; Hartmann, A; Hellerbrand, C; Merkel, S; Moceri, S; Schneider, J; Schüle, R; Seitz, T; Sommer, J; Steinkasserer, A; Trebicka, J; von Hörsten, S; Weber, GF; Wild, AB, 2023)
"Obesity is a multifactorial disease that is one of the major public health problems."( Dounias, G; Filetti, V; Kaźmierczak-Siedlecka, K; Matera, S; Musumeci, G; Rapisarda, L; Rapisarda, V; Roggio, F; Vecchio, M; Vitale, E, 2023)
"Obesity is the main cause of low-grade inflammation and oxidation, resulting in insulin resistance."( Chiang, CC; Hsieh, CC; Huang, CY; Huang, PY; Kuo, CH; Kuo, HC; Lin, PY, 2023)
"Obesity is a significant health problem worldwide, particularly in developed nations."( Abdel-Alnaby, M; Abdul-Aziz, AA; Atta, MN; Megahed, F; Shaban, NZ, 2023)
"Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms underlying susceptibility are poorly understood."( Almond, M; Barclay, WS; Byrne, AJ; Dunning, J; Edwards, MR; Farne, HA; Heaney, LM; Jackson, MM; Jha, A; Johnston, SL; Katsoulis, O; Kon, OM; Mallia, P; Openshaw, PJM; Pitts, O; Regis, E; Saunders, KA; Simpson, KD; Singanayagam, A; Snelgrove, RJ; Tunstall, T, 2023)
"People with obesity are at greater risk of cardiovascular diseases and metabolic conditions such as type 2 diabetes."( Bethlehem, RAI; Bullmore, ET; Cercignani, M; Dear, R; Dipasquale, O; Harrison, NA; Kitzbichler, MG; Martins, D; Romero-Garcia, R; Seidlitz, J; Turkheimer, F; Warrier, V, 2023)
"Obesity is a global health issue arising from the unhealthy accumulation of fat."( Alotaibi, BS; Anyanwu, GO; Batiha, GE; Ejike, UD; Gyebi, GA; Iqbal, J; Onyeneke, EC; Rauf, K; Usunobun, U; Zaib, S, 2023)
"Obesity is one of the critical risk factors for cognitive dysfunction."( Ding, W; Lin, C; Liu, X; Xia, X; Xie, Y; Xu, S; Yang, Y; Zhan, M; Zhang, L; Zhu, J, 2024)
"Overweight and obesity are associated with severe metabolic disorders and an increased risk of cardiovascular diseases."( Głowacki, M; Kolodziejski, PA; Leciejewska, N; Lehmenn, T; Nogowski, L; Nowak, KW; Pruszynska-Oszmalek, E; Rekas-Dudziak, A; Sassek, M, 2023)
"Obesity is strongly linked with several kinds of neurological and physiological disorders such as type 2 diabetes and cardiovascular diseases."( Ahmed, S; Asif, S; Bibi, A; Farhan, M; Rehman, S; Saeed, Z; Soomro, AA; Zehra, SR, 2023)
"Obesity is an energy metabolism pathology that paves the way for physical and psychological problems with excessive fat accumulation that can impair health."( Ağaçfidan, A; Alış, H; Altınok, Ö; Bayazıt, TO; Büyükaşık, S, 2023)
"Obesity is a complex disease caused by various factors, and synthetic drugs used to treat it can have side effects."( Chakravarthy, S; Chitra, V; Fuloria, NK; Fuloria, S; Gupta, G; Narayanan, J; Reshma, A; Sahu, R; Sekar, M; Selvaraj, S; Subramaniyan, V; Tamilanban, T, 2023)
"Obesity is a worldwide problem associated with an increased BC risk."( Ababneh, E; Alfaqih, MA; Elsalem, L; Khader, Y; Mhedat, K; Nusier, M, 2023)
"Obesity is a major health concern that lacks effective intervention strategies."( Dong, X; Gao, J; Guo, X; Peng, Z; Wang, X; Xu, L; Xu, Z; Zhang, L; Zhang, Z; Zhao, J, 2023)
"Maternal obesity is a risk factor for pregnancy complications."( Stevenson, DK; Wong, RJ; Zhao, H, 2023)
"Obesity is a risk factor of hepatic steatosis, a hallmark of non-alcoholic fatty liver disease (NAFLD) that affects nearly 25% of the worldwide population."( Kim, HA; Kim, HJ; Park, CM; Park, JC; Park, JW; Rhyu, DY; Thakuri, LS, 2024)
"Obesity is recognized as an independent risk factor for abdominal aortic aneurysm (AAA)."( Kaga, S; Mori, K; Nakajima, H; Nakamura, S; Ogawa, Y; Okuma, H; Tsuchiya, K; Uchinuma, H, 2023)
"Obesity is a multifactorial disease characterized by an excessive accumulation of fat, which in turn poses a significant risk to health."( Chumphoochai, K; Manohong, P; Meemon, K; Niamnont, N; Sobhon, P; Tamtin, M, 2023)
"Comprehensive obesity care plans combine appropriate interventions for individual patients."( Bramante, CT; Elmaleh-Sachs, A; Gudzune, KA; Jay, M; Nicklas, JM; Schwartz, JL, 2023)
"Obesity is one of the major contributors to the excess mortality seen in people with severe mental illness (SMI) and in low- and middle-income countries people with SMI may be at an even greater risk."( Ahmed, HU; Appuhamy, KK; Ashworth, M; Boehnke, JR; Chongtham, V; Chowdhury, AH; Garcia, OP; Holt, RIG; Huque, R; Manjunatha, S; Mitchell, A; Muliyala, KP; Onstenk, EK; Podmore, D; Rajan, S; Shiers, D; Siddiqi, N; Zavala, GA, 2023)
"Obesity is known to be associated with left ventricular diastolic dysfunction due to its effect on blood pressure and glucose tolerance."( Che Hassan, HH; Mohamad, SF; Nik Mahmood, NRK; Raffali, MA; Roslan, MH, 2023)

Context

ExcerptReference
"The prevalence of obesity has been investigated in pre-school and school-age children, in young conscripts and in workers at the Riuniti Hospital in Parma, and the results show that the problem of obesity in Italy is a serious one."( Caronna, S; Magnati, G; Pugnoli, C; Strata, A; Tirelli, F; Zuliani, U, 1977)
"Inanition and obesity have been shown to alter steroid metabolism but it is not known whether nutritional "microdifferences" (i."( Bradlow, HL; Fishman, J; Hellman, L; Zumoff, B, 1975)
"Obesity has been reported in developed as well as developing countries."( Dhurandhar, NV; Kulkarni, PR, 1992)
"Obesity has long been recognized as a major risk factor for the development of hypertension."( Landsberg, L; Parker, D; Troisi, R; Weiss, ST; Young, JB, 1991)
"Obesity has generally been thought to increase the risk of operative mortality and postoperative complications in surgical patients."( Hakala, TR; Holley, JL; Lopatin, WB; Shapiro, R; Starzl, TE; Tzakis, AG, 1990)
"Obesity has its major effect on insulin action at lower plasma insulin concentrations and we propose that this may in part be due to abnormalities of insulin action induced by an increased fat-free mass with a consequent enlargement of muscle cells, a reduced capillary supply, and reduced penetration of insulin into muscle in obese subjects."( Bogardus, C; Lillioja, S, 1988)
"Morbid obesity has been associated with increased risks for thrombotic diseases."( Batist, G; Bern, MM; Bistrian, B; Blackburn, G; Bothe, A; Haywood, E, 1983)
"Obesity has to be considered a connecting link between both of them, and it is accelerating their genesis."( Mertz, DP, 1982)
"Obesity has to be considered a connecting link between both of them, and it is accelerating their genesis."( Mertz, A; Mertz, DP, 1981)
"Obesity has well-known associations with non-insulin-dependent diabetes (NIDDM), hypertension, dyslipidaemia and coronary heart disease, as well as less obvious links with diseases such as osteoarthrosis and various malignancies; it also causes considerable problems through reduced mobility and decreased quality of life."( Dryden, S; Frankish, H; Wang, Q; Williams, G, 1994)
"Predisposition to obesity has been suggested to be related to a low energy expenditure (EE)."( Astrup, AV; Buemann, B, 1993)
"Obesity has been linked with age, sex and racial alterations in the functioning of the HPA axis which are reviewed."( Chalew, S; Nagel, H; Shore, S, 1995)
"Obesity has been identified as a risk factor for atherosclerosis, and fat distribution has proved to be a critical variable."( Adler, G; Ditschuneit, HH; Flechtner-Mors, M, 1996)
"Obesity has now become a major target for drug development not only for affecting obesity per se but also for managing and preventing comorbid conditions such as diabetes and cardiovascular disease."( Abdeen, MA; Frishman, WH; Michaelson, MD; Weiser, M, 1997)
"Obesity has also often been associated to a decreased sympathetic nervous system (SNS) activity, hence sympathomimetic agents have been proposed as a possible way to partially correct this situation."( Doucet, E; Tremblay, A, 1997)
"Although obesity has been strongly associated with increased leptin in humans, a significant percentage of leptin's variability remains unexplained."( Doulgerakis, DE; Flier, JS; Griveas, I; Kaklamani, VG; Liolios, AD; Mantzoros, CS; Moses, AC; Tritos, NA, 1998)
"Obesity has been reported to be associated with coronary artery disease and other atherosclerotic diseases."( Akishita, M; Ako, J; Eto, M; Hashimoto, M; Kozaki, K; Ouchi, Y; Sugimoto, N; Toba, K; Yoshizumi, M, 1998)
"Abdominal obesity has been suggested to be associated with perturbations of the regulation of the hypothalamic-pituitary-adrenal (HPA) axis."( Björntorp, P; Dallman, MF; Rosmond, R, 1998)
"Obesity has significant consequences for the reproductive system, depending upon the amount and distribution of body fat."( Clark, AM; Norman, RJ, 1998)
"Although obesity has become the most common metabolic disorder in the developed world and is highly associated with insulin resistance and noninsulin-dependent diabetes mellitus, the molecular mechanisms underlying these disorders are not clearly understood."( Hotamisligil, GS; Uysal, KT; Wiesbrock, SM, 1998)
"Recently however, obesity has been rated by the WHO as an unique disease, resulting in elevated morbidity and mortality."( Marhardt, K; Toplak, H, 1998)
"The prevalence of obesity has doubled in the last 10 years and is now reaching epidemic proportions."( Cahill, A; Lean, ME, 1999)
"Childhood obesity has been associated with elevated serum levels of total cholesterol, triglycerides, and low-density lipoproteins (LDLs)."( Blecker, U; Brown, R; Despinasse, B; Sothern, MS; Suskind, RM; Udall, JN, 2000)
"Obesity has increased at an alarming rate in recent years and is now a worldwide public health problem."( Friedman, JM, 2000)
"Abdominal obesity has a key role in the pathogenesis of prevalent and serious diseases and has been shown to be associated with an altered hypothalamic-pituitary-adrenal (HPA) axis function, which is regulated by endocrine feedback mediated via hippocampal glucocorticoid receptors (GR)."( Björntorp, P; Bouchard, C; Carlsson, B; Chagnon, M; Chagnon, YC; Holm, G; Lindell, K; Pérusse, L; Rosmond, R, 2000)
"Obesity has been associated with alterations in glucocorticoid metabolism in both man and rodents, but the underlying mechanisms remain undefined."( Kenyon, CJ; Livingstone, DE; Walker, BR, 2000)
"Obesity has long been known to accompany a host of chronic diseases, e."( Aronne, LJ, 2001)
"Overweight and obesity have not only a significant psychological impact but also result in an increased risk for development of numerous chronic and sometimes fatal diseases."( Aronne, LJ, 2001)
"Obesity has been shown to increase the risk or be associated with numerous conditions from cardiovascular disease and type II diabetes to erectile dysfunction and osteoarthritis."( Moyad, MA, 2001)
"We confirm that obesity has a negative effect on inhibin B serum level, which is not specific to PCOS."( Cortet-Rudelli, C; Decanter, C; Dewailly, D; Leroy, M; Maunoury-Lefebvre, C; Pigny, P; Thomas-Desrousseaux, P, 2002)
"Obesity has been shown to increase arterial pressure."( Correia, ML; Haynes, WG; Mark, AL; Morgan, DA; Sivitz, WI, 2002)
"In this study, obesity has been developed with high-calorie diet given for 8 weeks in Sprague-Dawley rats."( Sahin, YN; Suleyman, H; Umudum, Z; Yilmaz, A, 2002)
"Obesity has been implicated in the etiology of benign and malignant prostatic growth due to its influence on metabolic and endocrine changes."( Chokkalingam, AP; Dahle, SE; Deng, J; Gao, YT; Hsing, AW; Stanczyk, FZ, 2002)
"Although obesity has multiple etiologies, an overlooked possibility is an infectious origin."( Abbott, DH; Allison, DB; Atkinson, RL; Bradley, SM; Dhurandhar, NV; Israel, BA; Kemnitz, JW; Schultz-Darken, NJ; Whigham, LD, 2002)
"Obesity has become a leading public health concern."( Cummings, DE; Schwartz, MW, 2003)
"Obesity has increased at an alarming rate in recent years and is now a worldwide health problem."( Hase, T; Murase, T; Nagasawa, A; Suzuki, J; Tokimitsu, I, 2002)
"Obesity has now been identified as a chronic disease, a global epidemic (globesity) and a serious public health issue that leads to reduced life expectancy, an increased risk for many serious medical conditions and enormous healthcare costs."( Bosello, O; Carruba, MO; Ferrannini, E; Rotella, CM, 2002)
"Obesity has been a major concern in the horse industry for many years, and the recent discovery of leptin and leptin receptors in numerous nonequine species has provided a basis for new approaches to study this problem in equine."( Buff, PR; Daniel, JA; Djiane, J; Dodds, AC; Keisler, DH; McFadin, EL; Morrison, CD; Whitley, NC, 2002)
"Obesity has been separated from insulin resistance in some transgenic strains, providing new insights into the mechanisms that usually link these phenotypes."( Arch, JR, 2002)
"Obesity has been rising as a common social phenomenon."( Huang, ZY; Sun, ZJ, 2001)
"Sex and obesity have independent effects on basal VLDL-triacylglycerol kinetics."( Klein, S; Mittendorfer, B; Patterson, BW, 2003)
"Obesity has been associated with obstructive sleep apnea and hepatic steatosis."( Chiba, T; Chin, K; Hattori, N; Masuzaki, H; Matsumoto, H; Mishima, M; Muro, S; Nakamura, T; Nakao, K; Niimi, A; Ogawa, Y; Ohi, M; Sumi, K; Takahashi, K, 2003)
"Obesity has become a worldwide public health problem affecting millions of people."( Araujo, S; Deng, HW; Liu, YJ; Recker, RR, 2003)
"Obesity has a complicated relationship to both breast cancer risk and the clinical behavior of the established disease."( Rose, DP; Stephenson, GD, 2003)
"Obesity has been found to increase endometrial thickness independently."( Basbug, M; Erez, R; Ozçelik, B; Ozsahin, O; Serin, IS; Yilmazsoy, A, 2003)
"Obesity has become a worldwide epidemic with ever increasing incidence and public health problems in both developing and developed countries."( Al-Azemi, M; Omu, AE; Omu, FE, 2004)
"Obesity has a negative impact on the outcome of treatment of infertility."( Al-Azemi, M; Omu, AE; Omu, FE, 2004)
"World-wide obesity has risen to alarming levels."( Hermanussen, M; Tresguerres, JA, 2003)
"Obesity has reached epidemic proportions and has become one of the major health problems in developed countries."( Gonzales, M; Wlodek, D, 2003)
"Obesity has become an epidemic problem in western societies, contributing to metabolic diseases, hypertension, and cardiovascular disease."( Barthel, A; Bornstein, SR; Ehrhart-Bornstein, M; Hauner, H; Lamounier-Zepter, V; Langenbach, J; McCann, SM; Scherbaum, WA; Schraven, A; Willenberg, HS, 2003)
"Obesity has been hypothesized to be associated with BPH because of the endocrine changes in men that occur with age, including increased estrogen and decreased testosterone."( Abe, H; Matsuda, T; Suda, K, 2004)
"Obesity has become an epidemic problem in western societies, contributing to metabolic diseases, hypertension and cardiovascular disease."( Bornstein, SR; Ehrhart-Bornstein, M; Lamounier-Zepter, V, 2004)
"The incidence of obesity has increased sharply in recent years, making it one of the most urgent public health concerns worldwide."( Cohen, P; Friedman, JM, 2004)
"Obesity has become the most prevalent nutritional disorder in post-industrialised societies and it is associated with the development of severe and costly complications such as type 2 diabetes mellitus and coronary heart disease or cancer."( Krempler, F; Oberkofler, H; Patsch, W, 2002)
"The prevalence in obesity has increased dramatically over the past 30 years, more than double in the United States alone."( Joyal, SV, 2004)
"Obesity has nearly doubled in Oklahoma and in the US since 1990 while Oklahoma adult smoking rates have remained above 25%."( Campbell, JE; Tutor, CG, 2004)
"Obesity has reached epidemic levels in industrialized countries and is increasing worldwide."( Ahima, RS; Scharf, MT, 2004)
"Obesity has become an epidemic problem, contributing to metabolic syndrome, type 2 diabetes, hypertension, and cardiovascular disease."( Abellán, J; de Vinuesa, SG; García-Galbis, JA; Hernández-Menárguez, F; Leal, M; Luño, J; Martínez-Pastor, A, 2005)
"Obesity has become an epidemic problem in Western societies contributing to several disease processes including metabolic diseases, hypertension, and cardiovascular disease."( Arakelyan, K; Bornstein, SR; Ehrhart-Bornstein, M; Krug, AW; Scherbaum, WA, 2004)
"Obesity has been shown to be associated with increased left ventricular mass (LVM) and heart sympathetic activity even in nonhypertensive subjects."( Amador, N; Encarnación, JJ; Guízar, JM; López, M; Rodríguez, L, 2005)
"Obesity has been largely diagnosed based upon anthrompometric measurements like waist circumference (WC) and body mass index (BMI)."( Jeong, SK; Kim, YH; Kweon, SS; Nam, HS; Seo, MW, 2005)
"The prevalence of obesity has increased 15% up to 20% and represents an important challenge for the anesthesiologist in drug-dosing management."( Casati, A; Putzu, M, 2005)
"In recent years, obesity has gained the traditional tetrad of cardiovascular risk factors of smoking: hypertension, dyslipidemia, and dysglycemia."( Douketis, JD; Sharma, AM, 2005)
"Obesity has been shown to be associated with the supersaturation of bile with cholesterol because of increased hepatic secretion of the sterol."( Chavez-Tapia, N; Méndez-Sánchez, N; Ponciano-Rodrigoez, G; Uribe, M, 2005)
"The prevalence of obesity has markedly increased over the past two decades, especially in the industrialized countries."( Garofalo, C; Surmacz, E, 2006)
"World-wide obesity has risen to alarming levels."( García, AP; Hermanussen, M; Salazar, V; Sunder, M; Tresguerres, JA; Voigt, M, 2006)
"Obesity has been associated with advanced stage and a higher risk of biochemical progression following radical prostatectomy (RP) in several series."( Bruzek, DJ; Freedland, SJ; Mangold, LA; Mohr, P; Partin, AW; Platz, EA; Sokoll, LJ; Yiu, SK, 2005)
"Because obesity has become a national epidemic, it is critical that physicians are able to recognize and treat obesity-associated diseases."( Olson, AL; Zwillich, C, 2005)
"Childhood obesity has become a nutritional problem in China since the 1990s."( Greiner, T; Jiang, JX; Lian, GL; Rosenqvist, U; Xia, XL, 2005)
"Obesity has been associated with a higher incidence of Caesarean section and higher levels of epidural block have also been found in obese obstetric patients, suggesting they may require less local anaesthetic."( Columb, MO; Panni, MK, 2006)
"Obesity has emerged as a major cause of diabetes, cardiovascular disease, and renal insufficiency worldwide."( Li, Z; Ni, Z; Rodríguez-Iturbe, B; Sepassi, L; Shahkarami, A; Vaziri, ND, 2005)
"Although obesity has been reported to be associated with leptin "resistance," it is unclear whether obesity alters the cardiovascular and metabolic effects of chronic MC3/4-R activation."( Hall, JE; Kuo, JJ; Liu, J; Silva, AA; Tallam, LS, 2006)
"Visceral obesity has been associated with an increased cardiovascular risk."( Corthouts, B; Mertens, I; Van der Planken, M; Van Gaal, LF, 2006)
"Obesity has reached global epidemic proportions because of an increasingly obesogenic environment."( Behn, A; Ur, E, 2006)
"Obesity has provided considerable impetus for the investigation of the fundamental mechanisms involved in the regulation of energy balance."( Bing, C; Trayhurn, P; Wood, IS, 2006)
"Obesity has also been suggested to elevate serum GGT activities."( Anttila, P; Bloigu, R; Hietala, J; Koivisto, H; Niemelä, O; Puukka, K, 2006)
"Abdominal obesity has been found to be associated with an increased risk of deep vein thrombosis (DVT)."( Ageno, W; Romualdi, E; Squizzato, A, 2007)
"Obesity has been proposed to be a result of an imbalance in the physiological system that controls and maintains the body energy homeostasis."( Bjursell, M; Bohlooly-Y, M; Gerdin, AK; Huang, XF; Jönsson, M; Surve, VV; Svensson, L; Törnell, J, 2006)
"Obesity has possibly opposite effects on the incidence and outcome of myocardial infarction."( Heusch, G, 2006)
"Obesity has been described as the greatest current threat to human health."( Chaput, JP; Tremblay, A, 2006)
"Hyperinsulinemia in obesity has been attributed to insulin oversecretion by pancreatic beta-cells."( da Rocha, DN; de Freitas Mathias, PC; Grassiolli, S; Gravena, C; Marçal, AC; Puzzi, MA; Scomparin, DX, 2006)
"The prevalence of obesity has grown to an alarming level of at least 300 million people worldwide."( Schröder, H, 2007)
"In recent years, obesity has become a major public health problem in Western countries."( Bonanomi, G; Di Caro, S; Fernstrom, MH; Hamad, GG; Schauer, PR, 2006)
"Obesity has become a significant health problem in industrialised and developing countries, and despite all nutritional and behavioural approaches, its prevalence is still increasing."( Hofbauer, KG; Nicholson, JR, 2006)
"The prevalence of obesity has been increasing at a rapid rate over the last few decades."( Holness, MJ; Sugden, MC; Walker, CG; Zariwala, MG, 2007)
"Obesity has been implicated in several diseases, including cancer; however, the relationship of obesity and susceptibility to ultraviolet (UV) radiation-caused skin diseases has not been investigated."( Katiyar, SK; Meeran, SM, 2007)
"Obesity has a heritable component; however, the heterogeneity of obesity complicates dissection of its genetic background."( Adan, R; de Krom, M; Grobbee, DE; Hendriks, J; Ophoff, RA; Stolk, RP; van der Schouw, YT; van Gils, CH, 2007)
"Obesity has consistently been associated with increased colorectal cancer risk in men, but not in women."( Bostick, RM; Potter, JD; Terry, PD; Wolf, LA, 2007)
"Obesity has been suggested to have a detrimental impact on kidney structure and function, leading to focal glomerulosclerosis and hypertension."( Budge, H; Gardner, DS; Keisler, D; Kurlak, LO; Perkins, AC; Stephenson, T; Symonds, ME; Williams, PJ, 2007)
"Maternal obesity has been reported as a risk factor for various maternal and fetal complications."( Bielański, W; Brzozowski, T; Budziszewska, P; Cnota, W; Czuba, B; Konturek, PC; Kuka, D; Kukla, M; Rehfeld, JF; Sodowski, K; Włoch, A; Zdun, R; Zwirska-Korczala, K, 2007)
"Obesity has reached epidemic proportions in the United States; hence, it is frequently encountered in patients undergoing (18)F-FDG PET studies."( Botkin, CD; Osman, MM, 2007)
"While obesity has been historically considered a criteria to establish the diagnosis of hypothyroidism, the association between them is seldom encountered in patients."( Giusti, V; Portmann, L, 2007)
"Obesity has recently been proposed to be yet another adverse health consequence of exposure to endocrine disrupting substances during development."( Jefferson, WN; Newbold, RR; Padilla-Banks, E; Snyder, RJ, 2007)
"Obesity has been demonstrated to predict biochemical progression in men undergoing radical prostatectomy for prostate adenocarcinoma, and is associated with a higher risk of biochemical and clinical relapse after radiation therapy (RT)."( Palma, D; Pickles, T; Tyldesley, S, 2007)
"Obesity has recently become a focus of research to elucidate diet and lifestyle factors as important risk factors for colon cancer."( Arthur, JR; Barrera, LN; Drew, JE; Duthie, GG; Farquharson, AJ; Mercer, JG; Morrice, PC; Padidar, S, 2007)
"Obesity has a variety of adverse health outcomes, but to the authors' knowledge, the effect of obesity on outcome in patients with advanced prostate cancer is not known."( Halabi, S; Ou, SS; Small, EJ; Vogelzang, NJ, 2007)
"Obesity has become a global epidemic and carries a considerable negative impact in regard to quality of life and life expectancy."( Bodary, PF, 2007)
"However, obesity has been demonstrated to be a highly active endocrine organ with multiple metabolic pathways that interact with classic cardiac risk factors."( Farmer, JA; Mehta, S, 2007)
"Obesity has been associated with kidney disease in adults."( Chin, H; Falk, RJ; Ferris, M; Gibson, K; Gipson, DS; Hogan, SL; Jennette, JC; Shoham, DA; Yilmaz, S, 2007)
"Obesity has reached epidemic proportions across the developed world."( Halford, JC; Harrold, JA, 2006)
"Although obesity has been consistently linked to an increased risk of several malignancies, including cancers of the colon, gallbladder, kidney, and pancreas, its role in prostate cancer etiology remains elusive."( Chua, S; Hsing, AW; Sakoda, LC, 2007)
"Overweight and obesity have been associated with better survival in patients with chronic obstructive pulmonary disease (COPD)."( Doucet, M; Drapeau, V; Fournier, G; Maltais, F; Poirier, P; Poulain, M; Tremblay, A, 2008)
"Obesity has become a prevailing epidemic throughout the globe."( Huang, CJ; Li, JJ; Xie, D, 2008)
"Obesity has become a major health problem in many parts of the world."( Andersson, S; Dahlman-Wright, K; Gustafsson, JA; Lundholm, L; Ohlsson, C; Otsuki, M; Putnik, M, 2008)
"Rates of pediatric obesity have increased dramatically over the past decade."( Acosta, MC; Levin, FR; Manubay, J, 2008)
"The epidemic of obesity has been paralleled by an increase in the incidence of chronic kidney disease."( Chen, HM; Chen, HP; Li, LS; Li, SJ; Liu, ZH; Wang, QW, 2008)
"Obesity has been found to be a specific risk factor for joint infection."( Choong, PF; Dowsey, MM, 2008)
"Obesity has been shown to be a risk factor for transformation of episodic migraine to chronic form, and adipocytokines have been implicated to modulate some of the cytokins such as interleukin-6 and tumor necrosis factor, which also act in the neurogenic inflammation in migraine."( Demir, M; Guldiken, B; Guldiken, S; Tugrul, A; Turgut, N, 2008)
"Obesity has multiple causes and is determined by the interaction between genetic and environmental factors."( Aller, R; Conde, R; de Luis, DA; Gonzalez Sagrado, M; Izaola, O, 2008)
"Obesity has become a global epidemic with recent estimates of > 400 million obese adults."( Henderson, DC; Sharma, B, 2008)
"Human obesity has a strong genetic component."( Ranadive, SA; Vaisse, C, 2008)
"Obesity has been recognized as a worldwide public health problem."( Da Silva, JA; de Araujo, DR; Galembeck, E; Torres, BB; Yokaichiya, DK, 2008)
"Obesity has been associated with a chronic low degree inflammatory response, characterized by an increase of inflammatory adipocytokines like tumoral necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) as well as the synthesis of acute phase reactants such as haptoglobin."( Baena, MJ; Marcos-Gómez, B; Marti, A; Martínez, JA; Moreno-Aliaga, MJ; Pérez-Echarri, N; Pérez-Matute, P, 2008)
"Obesity has seen a similarly sharp increase in prevalence and is a major contributing factor to the rise in cardiovascular disease incidence."( Barouch, LA; Trivedi, PS, 2008)
"Obesity has been associated with an increased prevalence of asthma and poorer control of this disease."( Boulet, LP, 2008)
"Obesity has emerged as an epidemic worldwide."( Dwivedi, SN; Kapil, U; Kaur, S; Lakshmy, R; Sachdev, HP, 2008)
"The prevalence of obesity has considerably increased during the past thirty years."( Janssens, JP; Réthoret-Lacatis, C, 2008)
"The prevalence of obesity has reached epidemic proportion with enormous costs in both human lives and healthcare dollars spent."( Clegg, DJ; Seeley, RJ; Shi, H, 2009)
"Childhood obesity has reached epidemic proportions."( Budge, H; Fainberg, HP; Gardner, DS; Harvey, E; Sharkey, D; Symonds, ME; Wilson, V, 2009)
"Obesity has been linked with a chronic state of inflammation which may be involved in the development of metabolic syndrome, cardiovascular disease, non-alcoholic steatohepatitis, and even cancer."( Lane, J; Nguyen, NT; Nguyen, XM; Smith, BR, 2009)
"Weight increase and obesity have been identified as the most important risk and prognostic factors for breast cancer in postmenopausal women."( Macciò, A; Madeddu, C; Mantovani, G, 2009)
"Obesity has reached epidemic proportions in the USA with a nearly fourfold rise in the prevalence of childhood obesity."( Schuster, DP, 2009)
"Adult obesity has been associated with depression, especially in women."( Dabrowski, P; Gruszka, W; Janowska, J; Kocełak, P; Olszanecka-Glinianowicz, M; Semik-Grabarczyk, E; Wikarek, T; Zahorska-Markiewicz, B, 2009)
"At present, obesity has been recognized as a worldwide public health problem."( Lecube, A; Simó, R; Zafon, C, 2010)
"Obesity has been shown to be an indicator of poor prognosis for patients with primary breast cancer (BC) regardless of the use of adjuvant systemic therapy."( Andersson, M; Crown, JP; de Azambuja, E; Demol, J; Dewar, J; Di Leo, A; Francis, P; Gelber, RD; Giuliani, R; Gutiérez, J; Jakesz, R; Lluch, A; McCaskill-Stevens, W; Nordenskjöld, B; Olsen, S; Piccart-Gebhart, M; Quinaux, E; Santoro, A; Vicente, M; Vila, MM, 2010)
"Obesity has been strongly associated with the development and aggravation of hypertension and chronic kidney disease."( Chang, YS; Chung, HW; Chung, S; Kim, BS; Kim, GH; Kim, HW; Lee, JH; Lim, JH; Park, CW; Shin, SJ; Youn, DY, 2010)
"Obesity has become a major public health problem, most commonly treated via dietary restriction to promote weight loss."( Cicogna, AC; Conde, SJ; Leopoldo, AS; Lima-Leopoldo, AP; Luvizotto, RA; Nascimento, AF; Nogueira, CR; Padovani, CR; Síbio, MT, 2010)
"Obesity has become an epidemic in children, associated with an increase in insulin resistance and metabolic dysfunction."( Fleischman, A; Grinspoon, SK; Hrovat, M; Kron, M; Systrom, DM, 2009)
"The frequency of obesity has risen dramatically in recent years but only few safe and effective drugs are currently available."( Al Hakim, M; Astrup, A; Lean, ME; Madsen, J; Niskanen, L; Rasmussen, MF; Rissanen, A; Rössner, S; Van Gaal, L, 2009)
"The prevalence of obesity has increased dramatically worldwide, predisposing individuals to an increased risk of morbidity and mortality due to cardiovascular disease and type 2 diabetes."( Mancuso, P, 2010)
"Obesity has been implicated as a risk factor for periodontitis and non-alcoholic fatty liver disease (NAFLD)."( Ekuni, D; Furuta, M; Irie, K; Koyama, R; Kuroki, K; Morita, M; Sanbe, T; Tobe, K; Yamamoto, T; Yamanaka, R, 2010)
"Obesity has rapidly become a life-threatening epidemic worldwide."( McClendon, KS; Riche, DM; Uwaifo, GI, 2009)
"In vivo, obesity has led to downregulation of adipose PPARdelta expression."( Wolf, G, 2010)
"Obesity has been associated with an increased risk of developing several psychiatric illnesses, including major depression and posttraumatic stress disorder."( Chuang, JC; Cui, H; Elmquist, JK; Krishnan, V; Lutter, M; Mason, B; Nestler, EJ; Wilkinson, MB; Yu, HG; Zigman, JM, 2010)
"Obesity has been linked with poorer vitamin D status."( Andrés, P; Aparicio, A; Bermejo, LM; López-Sobaler, AM; Ortega, RM; Perea, JM; Rodríguez-Rodríguez, E, 2009)
"Obesity has been implicated in several inflammatory diseases and in different types of cancer."( Katiyar, SK; Sharma, SD, 2010)
"In recent years, obesity has been identified as a risk factor for the development of breast cancer in postmenopausal women, and it has been associated with a poor outcome."( Cleary, MP; Grossmann, ME; Ray, A, 2010)
"Obesity has a complex relationship to breast cancer risk that differs in premenopausal and postmenopausal women."( Rose, DP; Vona-Davis, L, 2010)
"While obesity has been shown to be associated with a worse mortality, an "obesity paradox"--lower mortality in obese patients--has been noted among many patients with coronary artery disease (CAD)."( Atluri, P; Joshi, R; Khokhar, SS; Koppuravuri, HK; Mandeva, A; Rozanski, A; Singh, P; Supariwala, A; Uretsky, S, 2010)
"Obesity has reached epidemic proportions and is continuing to grow into one of the leading healthcare issues worldwide."( Shikora, S; Spector, D, 2010)
"The prevalence of obesity has grown to an alarming magnitude, affecting more than 300 million humans worldwide."( Araujo, EP; Torsoni, MA; Velloso, LA, 2009)
"The prevalence of obesity has steadily increased over the last few decades."( Ailhaud, G; Amri, EZ; Barbry, P; Guesnet, P; Joly, A; Luquet, S; Massiera, F; Mohsen-Kanson, T; Moreilhon-Brest, C, 2010)
"Diabetes and obesity have been established as independent risk factors for the development of HCC."( Calcagno, CJ; Harrison, SA; Starley, BQ, 2010)
"Obesity has a negative effect on fertility, and may play a role in the development of the polycystic ovary syndrome in susceptible women."( Akamine, EH; Bevilacqua, E; Camporez, JP; Caperuto, LC; Carvalho, CR; Hoshida, MS; Marçal, AC, 2010)
"The prevalence of obesity has dramatically increased over the past decade along with the cardiovascular and other health risks it encompasses."( Clegg, DJ; Nedungadi, TP, 2009)
"Obesity has adverse consequences in the general population."( Teta, D, 2010)
"Obesity has been epidemic in the US for over two decades; almost 65% of adults in the US are overweight."( Hakkak, R; Jo, CH; Korourian, S; MacLeod, S; Shaaf, S, 2010)
"Obesity has become a major health problem and epidemic."( Gold, MS; Kobeissy, FH; Liu, Y; von Deneen, KM, 2010)
"Childhood obesity has increased to epidemic levels and is considered a public health problem due to its association with a number of metabolic abnormalities, which are being detected at earlier stages of life."( Briones, E; Castelán, K; Palacios, GC; Romero, JB, 2010)
"Obesity has been associated with increased incidence and aggressiveness of prostate cancer."( Aguas, AP; Andrade, S; Costa, M; Lopes, C; Monteiro, JD; Monteiro, MP; Pinho, F; Ribeiro, AM, 2010)
"Obesity has been recognized as an important risk factor for many serious medical conditions."( Legakis, I; Syrigos, K, 2010)
"The incidence of obesity has dramatically increased in overall the world."( Abid, H; Benammar Elgaaied, A; Clerget Froidevaux, MS; Demeneix, B; Guissouma, H; Jarboui, S; Kouidhi, S; Zaouche, A, 2010)
"Obesity has been associated with glomerular hyperfiltration, whereas obesity-related effects on tubular secretion are not well characterized."( Pai, MP, 2010)
"Obesity has an impact on renal function due to its hemodynamic, metabolic, and hormonal effects."( Kriachkova, AA; Kutyrina, IM; Savel'eva, SA; Shestakova, MV, 2010)
"Because obesity has been equated with addiction, and because of their evolutionary commonalities, we chose to examine the metabolic, hedonic, and societal similarities between fructose and its fermentation byproduct ethanol."( Lustig, RH, 2010)
"Obesity has become a major public health problem worldwide."( Atar, E; Bachar, GN; Dicker, D; Herskovitz, P; Katz, M, 2010)
"The frequency of obesity has been increasing worldwide for 20 years."( Guiu, B; Hillon, P; Petit, JM; Vincent, J, 2010)
"Obesity has reached epidemic proportions worldwide and is stimulated by the ready availability of food rich in fat and sugar (highly palatable diet)."( Böhmer, AE; Knorr, L; Lesczinski, DN; Lhullier, F; Moreira, JD; Müller, AP; Oses, JP; Perry, ML; Souza, CG; Souza, DG; Souza, DO; Viola, GG, 2010)
"Although obesity has been associated with several effects in rodents, few investigations have evaluated the metabolic, endocrine, and cardiac parameters of spontaneously hypertensive rats (SHR) with dietary-induced obesity."( Campos, DH; Cicogna, AC; Dal Pai-Silva, M; Leopoldo, AS; Lima-Leopoldo, AP; Martinez, PF; Okoshi, K; Okoshi, MP; Oliveira Junior, SA; Padovani, CR, 2010)
"Study of Mendelian obesity has also added significantly to our understanding of mechanisms of appetite regulation, with all known causative genes being active in the brain and most forming part of the leptin-melanocortin signaling pathway."( Blakemore, AI; Froguel, P, 2010)
"The prevalence of obesity has increased worldwide and is particularly high among middle-aged women and men."( Barton, M; Clegg, DJ; Meyer, MR; Prossnitz, ER, 2011)
"Childhood obesity has more than tripled in the past 30 years."( Browning, B; Donaldson, A; Halverson, T; Kletzel, M; Shinkle, M; Thormann, K, 2011)
"Obesity has been shown to impair myocardial performance."( Alves, CA; Brum, PC; Castardeli, E; Cicogna, AC; de Campos, DH; do Nascimento, AF; Leopoldo, AS; Lima-Leopoldo, AP; Luvizotto, Rde A; Sugizaki, MM, 2011)
"Obesity has numerous adverse effects on general, and especially, cardiovascular health."( Chen, JW; Huang, CH; Lin, SJ; Sung, SH; Wu, TC, 2011)
"In adults, obesity has been associated with disinhibited eating, decreased cortical gray matter (GM) volume, and lower performance on cognitive assessments."( Convit, A; Hoogendoorn, C; Maayan, L; Sweat, V, 2011)
"Late-life obesity has been linked to declines in physical health and cognitive function, with implications not only for the individual, but also for society."( Green, E; Haase, L; Jacobson, A; Murphy, C, 2011)
"Male obesity has been linked with a reduction in sperm concentration and motility, an increase in sperm DNA damage and changes in reproductive hormones."( Bakos, HW; Tremellen, K; Tunc, O, 2011)
"Adolescent obesity has dramatically increased in recent decades, and along with that so have other medical comorbidities, such as hypertension, diabetes, hyperlipidemia, nonalcoholic steatohepatitis, polycystic ovary syndrome (PCOS), and pseudotumor cerebri."( Hillman, JB; Inge, TH; Miller, RJ, 2011)
"Obesity has reached epidemic proportions worldwide and is related with many comorbidities."( Faltaka, A; Gkotsina, MI; Kalfarentzos, F; Mamali, I; Markantes, GK; Markou, KB; Michalaki, MA; Vagenakis, AG, 2011)
"Childhood obesity has become a prevalent risk to health of children and teenagers."( Blachier, F; Hao, F; He, Q; Kong, X; Li, P; Ren, P; Tang, H; Wu, G; Wu, Y; Yin, Y, 2012)
"Obesity has been classified as a growing epidemic and its associated metabolic disorders are considered a major risk to the health system."( Ha, T; Lee, YS; Shehzad, A; Subhan, F, 2011)
"Obesity has been recognized as an independent risk factor for arterial hypertension."( De Pergola, G; Guida, P; Nardecchia, A; Silvestris, F, 2011)
"Type 2 diabetes and obesity have emerged as global public health crises."( Bhatnagar, A; Hellmann, J; Kosuri, M; Spite, M; Tang, Y, 2011)
"Obesity has been associated with both the carcinogenesis and poor prognosis of colon cancer, one of the leading causes of cancer-related death."( Chen, J; Hu, C; Huang, XF; Katsifis, A, 2011)
"Diet-induced obesity has contrasting effects on BK(Ca) function in different vascular beds, through differential effects on β(1)-subunit expression."( Ellis, ZE; Grayson, TH; Howitt, L; Morris, MJ; Murphy, TV; Sandow, SL, 2011)
"For decades, obesity has been considered to be the result of the complex interaction between genes and the environment and its pathogenesis is still unresolved."( Carbone, F; Cassano, S; De Rosa, V; Galgani, M; La Rocca, C; Matarese, G; Procaccini, C, 2011)
"Obesity has implications for chemotherapy dosing and selection of patients for therapy."( Ballen, K; Bashey, A; Freytes, C; Gibson, J; Hari, P; Heitjan, DF; Holmberg, L; Kamble, R; Kyle, RA; Lazarus, HM; Maharaj, D; Maiolino, A; McCarthy, PL; Pérez, WS; Roy, V; Stadtmauer, EA; Vesole, D; Vogl, DT; Wang, T; Weisdorf, D, 2011)
"Obesity has become an epidemic in industrialized and developing countries."( Korkmaz, A; Ma, S; Reiter, RJ; Tan, DX, 2012)
"Obesity has been implicated in the etiology of postmenopausal breast cancer (PBC)."( Dalamaga, M; Karmaniolas, K; Lekka, A; Papadavid, E; Pelekanos, N; Sotiropoulos, G, 2011)
"Obesity has become a major health problem worldwide."( Jin, ZM; Zhu, HJ, 2011)
"Asthma and obesity have been increasing in prevalence internationally among children."( Collins, CE; Gibson, PG; Jensen, ME; Wood, LG, 2011)
"Obesity has been associated with compromised tissue oxygenation and reduced organ perfusion."( Butler, C; Chanderraj, R; Faerber, J; Frangos, S; Gant, R; Kofke, WA; Kumar, MA; LeRoux, P; Levine, JM; Maloney-Wilensky, E, 2012)
"Obesity has been linked to acute lung injury and is a risk factor for early mortality after lung transplantation."( Arcasoy, SM; Bhorade, S; Christie, JD; Crespo, M; Diamond, JM; Kawut, SM; Lama, VN; Lederer, DJ; Lee, J; Orens, JB; Palmer, SM; Sonett, JR; Ware, LB; Weinacker, A; Wickersham, N; Wille, KM; Winterbottom, C, 2011)
"Obesity has been identified as a risk factor for osteoarthritis."( Bierma-Zeinstra, SM; Clockaerts, S; Koes, BW; Runhaar, J, 2011)
"Obesity has an overall negative impact on fertility, affecting both women and men."( Brannian, JD, 2011)
"The prevalence of obesity has increased substantially over recent years."( Arya, R; Patel, JP; Roberts, LN, 2011)
"Maternal obesity has been linked to an increased incidence of stillbirths, fetal macrosomia, fetal intrauterine growth restriction and pre-eclampsia."( Dick, EJ; Ferry, RJ; Hubbard, GB; Mari, G; Samson, JE; Schlabritz-Loutsevitch, NE, 2011)
"Obesity has been associated with increased consumption of sweetened beverages and a high-fat diet."( Apolzan, JW; Harris, RB, 2012)
"One of them, obesity, has been reported to exert a harmful influence on asthma control."( Arakawa, M; Gejyo, F; Hasegawa, T; Koya, T; Narita, I; Sakagami, T; Suzuki, E; Suzuki, K; Toyabe, S; Youkou, A, 2011)
"Obesity has increased rapidly in South African children and adolescents."( Erasmus, RT; Fanampe, BL; Hassan, MS; Matsha, TE; van der Merwe, L; van Rensburg, SJ; Yako, YY, 2011)
"Obesity has complex effects on allergic inflammation and is likely to be important modifier of the pathogenesis of airway disease in asthma."( Cohen, RI; Dixon, AE; Griffes, LV; Johnson, SE; Ramdeo, R; Raymond, DM; Soloveichik, A; Suratt, BT, 2011)
"Human obesity has been associated with alterations of vascular structure, especially in large and medium arteries, but the effects of insulin-sensitizers are not well known."( Burlá, AK; Fortes, ZB; Lobato, NS; Neves, MF; Oigman, W, 2013)
"The prevalence of obesity has increased dramatically worldwide."( Davis, AR; Daws, LC; Galli, A; Kennedy, JP; Lindsley, CW; Matthies, HJ; Neve, RL; Niswender, KD; Owens, WA; Russo, SJ; Saadat, S; Saunders, C; Speed, N; Vaughan, RA, 2011)
"The prevalence of obesity has dramatically increased during the past two decades."( Cutrone, A; Donati, MB; Lorenzet, R; Napoleone, E, 2012)
"Childhood obesity has a great impact on adult cardiovascular morbidity and mortality; treatment of this pathological state is important given the significant health consequences."( Bajnok, L; Harangi, M; Józsa, L; Koncsos, P; Nagy, EV; Páll, D; Paragh, G; Seres, I, 2011)
"Obesity has recently been shown to have a favorable effect on the prognosis of patients with congestive heart failure (CHF), but only a few such studies are available in Japan."( Abe, Y; Arase, S; Date, T; Fujii, S; Hongo, K; Kawai, M; Kayama, Y; Komukai, K; Minai, K; Morimoto, S; Nagoshi, T; Nakane, T; Ogawa, K; Ogawa, T; Sekiyama, H; Taniguchi, I; Yoshimura, M, 2012)
"Weight increase and obesity have been identified as the most important risk and prognostic factors for breast cancer in postmenopausal women."( Macciò, A; Madeddu, C, 2011)
"Obesity has a negative effect on male reproductive function."( Carrell, DT; Gibson, M; Hammoud, AO; Meikle, AW; Peterson, CM, 2012)
"Is well known that obesity has increased significantly in recent times and therefore many dietary supplements, synthetic or natural, have been proposed in order to prevent and/or to treat obesity or overweight."( de Oliveira, HP; Rodrigues, MR, 2012)
"Obesity has been associated with abnormally high expression of the enzyme aromatase in the breast, increased local estrogen production, and predisposition to breast hyperplasia and cancer."( Brooks, DC; Bulun, SE; Chen, D; Moy, I; Zhao, H, 2012)
"The prevalence of obesity has reached epidemic proportions and is associated with several co-morbid conditions including diabetes, dyslipidemia, cancer, atherosclerosis and gallstones."( Caldwell, MT; Edgel, KA; Houston, BA; Leboeuf, RC; Mai, PO; McMillen, TS; Oram, JF; Pamir, N; Tang, C; Wei, H, 2012)
"Obesity has been associated with metabolic complications."( Aubertin-Leheudre, M; Barbat-Artigas, S; Filion, ME; Plouffe, S, 2012)
"Obesity has various deleterious effects on health largely associated with metabolic abnormalities including abnormal glucose and lipid homeostasis that are associated with vascular injury and known cardiac, renal, and cerebrovascular complications."( Lee, EB, 2011)
"While obesity has been linked to poor outcomes after total knee or hip replacement, there are no data addressing outcomes in obese patients who underwent total ankle replacement (TAR)."( Anderson, AE; Barg, A; Hintermann, B; Knupp, M, 2011)
"The prevalence of obesity has been increasing in the United States."( Cheung, BM; Leung, RY; Ong, KL; Samaranayake, NR, 2012)
"Obesity has become a major global health problem."( Anastasovska, J; Arora, T; Bell, JD; Frost, G; Gibson, GR; Goldstone, AP; Hankir, MK; Modi, N; Nadkarni, NA; Parkinson, JR; Sanchez Canon, GJ; So, PW; Thomas, EL; Touhy, K; Van Loo, J, 2012)
"To date, obesity has not been listed as an indication for pulmonary rehabilitation (PR), hence the reason why conclusive data on the impact of obesity per se on PR are lacking."( Dreher, M; Kabitz, HJ, 2012)
"Obesity has been associated with low-grade systemic inflammation and with micronutrient deficiencies."( García, OP, 2012)
"In modern society, obesity has become a major health problem and has been associated with impaired fertility."( Caserta, D; Lisi, F; Lo Monte, G; Marci, R; Moscarini, M; Patella, A; Soave, I, 2012)
"The prevalence of obesity has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system."( Ansari, JA; Bhandari, U; Haque, SE; Pillai, KK, 2012)
"Obesity has no association with levels of serum follicle stimulating hormone, luteinizing hormone, estradiol, prolactin and thyroid stimulating hormone."( Atakul, N; Erel, CT; Imamoğlu, M; Küçük, M; Sahmay, S; Seyisoğlu, H; Usta, T, 2012)
"Obesity has reached epidemic proportions worldwide."( Brauer, HA; Freemerman, AJ; Galanko, JA; Ilkayeva, OR; Kuan, PF; Makowski, L; Muehlbauer, MJ; Newgard, CB; O'Connell, TM; Sampey, BP; Stevens, RD; Troester, MA; Zhang, J, 2012)
"Obesity has little effect on stone composition until a very high (>40) BMI is reached."( Fridirici, ZC; Greco, K; Hart, ST; Kadlec, AO; Turk, TM; Vellos, T, 2012)
"Obesity has reached epidemic proportions in the Western world and is implicated in the pathophysiology of essential hypertension."( Leite-Moreira, A; Moreira-Rodrigues, M; Pestana, M; Quelhas-Santos, J; Roncon-Albuquerque, R; Sampaio-Maia, B; Serrão, P, 2012)
"Obesity has been identified as a major risk factor for type 2 diabetes, characterized by insulin resistance in insulin target tissues."( Gavrilova, O; Gonzalez, FJ; Jiang, C; Kim, JH; Li, F; Qu, A; Shah, YM, 2013)
"Obesity has been considered one of the leading causative agents for diseases such as type 2 diabetes, stroke, and heart attack."( Kose, H; Matsumoto, K; Yamada, T, 2012)
"Obesity has been associated with multiple chronic pain disorders, including migraine."( Caudle, RM; Kothari, SD; Kuburas, A; Luu, AK; Neubert, JK; Recober, A; Rossi, HL, 2013)
"Obesity has been linked to many adverse health consequences, including breast cancer."( Abdulkareem, A; Al-Daghri, N; Alenad, AM; Alnaami, AM; Alokail, MS; Chrousos, GP; Draz, HM; Sabico, S; Yakout, SM, 2013)
"67 adolescents with obesity have been examined."( Gladun, E; Lezhenko, G, 2013)
"Pre-pregnancy obesity has been associated with adverse birth outcomes."( Bodnar, LM; Chang, CC; Evans, RW; Luther, JF; Newby, PK; Tomedi, LE; Wisner, KL, 2013)
"Although obesity has been associated with larger prostate volumes (PV), few studies have actually investigated whether obesity enhances PV growth, especially among men using 5α-reductase inhibitors."( Andriole, G; Fleshner, N; Freedland, SJ; Gerber, L; Hamilton, RJ; Moreira, DM; Muller, RL; Parsons, JK, 2013)
"Treating obesity has proven to be an intractable challenge, in part, due to the difficulty of maintaining reduced weight."( Cordell, M; Hinkle, W; Hirsch, J; Leibel, R; Rosenbaum, M, 2013)
"Obesity has emerged to be a global threat to mankind."( Anburajan, M; Kishore Mohan, KB, 2013)
"Obesity has become an epidemic in the United States and its prevalence continues to increase."( Baker, WL; Luon, D; Nigro, SC, 2013)
"As obesity has reached epidemic proportions, the management of this global disease is of clinical importance."( Astell, KJ; Mathai, ML; Su, XQ, 2013)
"Obesity has been associated with cognitive decline in longitudinal studies of older individuals."( Bove, RM; Bredella, MA; Brick, DJ; Gerweck, AV; Healy, BC; Mancuso, SM; Miller, KK; Sherman, JC, 2013)
"Obesity has been revealed as one of the breast cancer risk factors, known to be associated with high levels of circulating insulin and decreased levels of adiponectin."( Asakura, S; Hirata, K; Kutomi, G; Minatoya, M; Mori, M; Nagata, Y; Otokozawa, S; Sugiyama, Y, 2013)
"Obesity has increased in children and adolescents."( Abdalla, DS; Damasceno, NR; Mello, AP; Sanches, LB; Silva, IT, 2013)
"Obesity has emerged as a leading environmental risk factor for the development of CRC."( Fan, D; Guffey, CR; Murphy, EA; Singh, UP, 2013)
"Obesity has been associated with a positive influence on bone mass."( Crabtree, N; Kirk, JM; Shaikh, MG; Shaw, NJ, 2014)
"Overweight and obesity have a major impact on global health; their prevalence has rapidly increased in all industrialized countries in the past few decades and diabetes and hypertension are their direct consequences."( Peña, S; Pérez-Álvarez, JA; Sayas-Barberá, E; Sendra, E; Trigueros, L; Ugidos, AV, 2013)
"Male obesity has been associated with altered semen parameters and reproductive hormonal levels, including a reduced testosterone:estradiol (T:E₂) ratio."( Polotsky, AJ; Stephens, SM, 2013)
"Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk factor for several common types of cancer."( Atarashi, K; Hara, E; Hattori, M; Honda, K; Ishikawa, Y; Iwakura, Y; Kanda, H; Loo, TM; Morita, H; Ohtani, N; Oshima, K; Oyadomari, S; Sato, S; Yoshimoto, S, 2013)
"Obesity has been implicated as a risk factor for several conditions including cardiovascular disease, diabetes, etc."( Gelli, V; Palle, AR; Reddy, CM; Reddy, KK; Shankar, BS; Sudhakar, J, 2013)
"The incidence of obesity has increased dramatically over the past several years, and in parallel, so has the prevalence of type 2 diabetes (T2D)."( Kirchgessner, A; Lakhan, SE, 2013)
"Obesity has been associated with a more severe disease course in inflammatory bowel disease (IBD) and epidemiological data identified dietary fats but not obesity as risk factors for the development of IBD."( Gruber, L; Haller, D; Kisling, S; Klingenspor, M; Lichtenegger, M; Lichti, P; Martin, FP; May, S; Rychlik, M, 2013)
"Obesity has been identified as an important risk factor in the development of cardiovascular diseases; however, other factors, combined or not with obesity, can influence cardiovascular risk and should be considered in cardiovascular risk stratification in pediatrics."( Borges, TS; Burgos, LT; Burgos, MS; Camargo, MD; Franke, SI; Prá, D; Reckziegel, MB; Reuter, CP; Silva, AM; Todendi, PF, 2013)
"Obesity has a protective effect against osteoporosis and this effect has been attributed to a high body fat content."( Atay, A; Bal, S; Gurgan, A; Kocyigit, H; Koseoglu, M, 2013)
"Obesity has reached epidemic proportions globally and has become the cause of several major health risks worldwide."( Bruun, CV; Christoffersen, BØ; Cirera, S; Elbrønd, VS; Fredholm, M; Jensen, MS; Jørgensen, CB; Kadarmideen, HN; Karlskov-Mortensen, P; Moesgaard, SG; Skovgaard, K, 2014)
"Obesity has become a worldwide health problem."( Ahmad, MA; Ansari, SH; Haque, MR; Najmi, AK, 2014)
"Obesity has been associated with increased incidence and mortality of breast cancer."( Bunnell, BA; Burow, ME; Gimble, JM; Rhodes, LV; Semon, JA; Shi, Z; Strong, AL; Strong, TA; Zhang, S; Zhang, X, 2013)
"Obesity has been regarded as a single best predictor and major controllable contributor to hypertension."( De, S; Dhara, PC; Maity, P; Pal, A; Sengupta, P, 2014)
"The prevalence of obesity has steadily increased over the past three decades both in the United States and worldwide."( Bapat, P; Chen, L; Kwun, I; Mo, H; Moustaid-Moussa, N; Shastri, A; Shen, CL; Su, R; Wang, S, 2014)
"Obesity has been associated with changes in the composition and function of the intestinal microbiota."( Ackermans, MT; Blaak, EE; Dallinga-Thie, GM; de Vos, WM; Fuentes, S; Groen, AK; Hoekstra, JB; Holleman, F; Holst, JJ; Jonker, L; Kema, IP; Knaapen, M; Knop, FK; Kootte, RS; Nieuwdorp, M; Out, C; Reijnders, D; Reuling, I; Romijn, JA; Serlie, MJ; Soeters, MR; Stroes, ES; van der Ley, C; van Nood, E; Vrieze, A; Zoetendal, EG, 2014)
"Obesity has been receiving an increasing amount of attention recently, but investigations regarding the potential impact of obesity, sexual behaviors, and sex hormones on erectile dysfunction (ED) in men have not completely clarified the association."( Chao, IC; Chao, JK; Hao, LJ; Ma, MC; Shi, MD, 2014)
"Obesity has been shown to have profound effects on hemodynamics and neurological states in humans."( Acevedo, EO; Evans, RK; Franco, RL; Huang, CJ; Mari, DC, 2014)
"Obesity has been associated with increased bone mass, but the mechanisms involved are still poorly understood."( Beghetti, M; Belli, DC; Farpour-Lambert, NJ; Maggio, AB; McLin, VA; Puigdefabregas, JW; Rizzoli, R, 2014)
"Obesity has emerged as a major contributing risk factor for overactive bladder (OAB), but no study examined urethral smooth muscle (USM) dysfunction as a predisposing factor to obesity-induced OAB."( Alexandre, EC; Antunes, E; Calmasini, FB; Davel, AP; De Nucci, G; Leiria, LO; Mendes-Silvério, CB; Mónica, FZ; Silva, FH, 2014)
"Obesity has been linked to a wide spectrum of malignancies, with the strongest association demonstrated for endometrial cancer."( Bovbjerg, DH; Burke, LE; Edwards, RP; Freese, KE; Komaroff, M; Linkov, F; Lokshin, A; Styn, MA; Tseytlin, E, 2014)
"Although obesity has been associated with metabolic and cardiac disturbances, the carrier mechanisms for these responses are poorly understood."( Campos, DH; Cicogna, AC; Fernandes, T; Guizoni, DM; Martinez, PF; Okoshi, K; Okoshi, MP; Oliveira, EM; Oliveira-Junior, SA; Padovani, CR, 2014)
"Overweight and obesity have been associated with increase in cardiometabolic risk."( Ceballos, G; Chamorro-Cevallos, G; Garduño-Siciliano, L; Gutiérrez-Salmeán, G; Meaney, E; Ortiz-Vilchis, P; Ramírez-Sánchez, I; Vacaseydel, CM; Villafaña, S; Villarreal, F, 2014)
"Obesity has been studied as a metabolic and an inflammatory disease and is characterized by increases in the production of pro-inflammatory adipokines in the adipose tissue."( Daumann, F; de Andrade, VM; de Lira, FS; de Santana, AA; de Souza, CT; Dias, FM; Leffa, DD; Luciano, TF; Marques, Sde O; Neves, RX; Oyama, LM; Possato, JC; Rodrigues, B; Rosa, JC, 2014)
"Obesity has become an epidemic in worldwide population."( Giridharan, NV; Inagadapa, PJ; Jeyapal, S; Kalashikam, RR; Raghunath, M; Thomas, AE, 2014)
"Obesity has been reported to promote DMBA-induced tumors, but it remains unknown whether obesity affects ovarian xenobiotic metabolism."( Ganesan, S; Keating, AF; Nteeba, J, 2014)
"Obesity has been considered as an important risk factor for the development of colorectal cancer (CRC), but the association has not been fully elucidated."( Joshi, RK; Lee, SA, 2014)
"Obesity has increased dramatically over the past decades, reaching epidemic proportions."( Balaguer, P; Bernard, L; Bondesson, M; Grimaldi, M; Gustafsson, JA; Hillenweck, A; Laudet, V; McCollum, CW; Perdu, E; Pinto, CL; Riu, A; Zalko, D, 2014)
"Obesity has become a major chronic disorder affecting a large population more than any other disease in the world."( Joshi, AV; Joshi, BA; Karikatti, SS; Katti, SM; Mallapur, MD, 2013)
"Obesity has become a worldwide epidemic that poses substantial health problems for both individuals and society."( Häring, HU; Hu, FB; Schulze, MB; Stefan, N, 2013)
"Obesity has been associated with elevated serum PTH (sPTH) in the general population."( Adams-Huet, B; Grange, JS; Holt, SA; Maalouf, NM; Nwariaku, FE; Rabaglia, JL; Tran, H; Woodruff, SL, 2014)
"The prevalence of obesity has been increasing worldwide."( Fülöp, P; Harangi, M; Lőrincz, H; Paragh, G; Seres, I; Somodi, S, 2014)
"Obesity has been associated with changes in brain structure, cognitive deficits, dementia and Alzheimer׳s disease."( Arnoldussen, IA; Gustafson, DR; Kiliaan, AJ, 2014)
"Obesity has shown a positive association with depression."( Chen, CC; Lin, CH; McIntyre, RS; Wong, J, 2014)
"The impact of CR on obesity has been examined with human intervention studies, which showed alterations in circulating adipokines."( Mariman, EC; Noben, JP; Renes, J; Rosenow, A; Roumans, N, 2014)
"Obesity has been associated with increased levels of hemostatic factors."( Allison, MA; Heo, M; Hou, L; Kabat, GC; Nassir, R; Rohan, TE; Zaslavsky, O, 2014)
"Obesity has been associated with increased incidence and mortality of breast cancer."( Al-Daghri, NM; Alenad, A; Alokail, MS; Mohammed, AK; Vanhoutte, P, 2014)
"Obesity has become a worldwide epidemic."( Arola, L; Arola-Arnal, A; Baselga-Escudero, L; Bladé, C; Casanova, E; Cedó, L; Pinent, M; Ribas-Latre, A; Salvadó, MJ, 2014)
"Obesity has become one of the major public health concerns of the past decades, because it is a key risk factor for type 2 diabetes, cardiovascular diseases, dyslipidemia, hypertension, and certain types of cancer, which may lead to increased mortality."( Blüher, M, 2014)
"Obesity has been reported as a pro-inflammatory state with elevated baseline CRP values."( Barsoum, WK; Higuera, CA; Klika, AK; Liu, JZ; Saleh, A, 2014)
"The prevalence of obesity has increased remarkably in the past four decades."( Hill, BG; Sansbury, BE, 2014)
"Whether obesity has a pathogenic role in thyroid disease remains largely a matter of investigation."( Biondi, B; Ceccarini, G; Chiovato, L; Ippolito, S; Marzullo, P; Pagano, L; Rotondi, M; Santini, F, 2014)
"Obesity has emerged as a leading health threat but its biological basis remains insufficiently known, hampering the search for novel treatments."( Bumb, JM; Grosshans, M; Kiefer, F; Leweke, FM; Meyer-Lindenberg, A; Rohleder, C; Schaefer, C; Schwarz, E; Tost, H; Vollmert, C; Vollstädt-Klein, S, 2014)
"Obesity has been associated with impaired executive functions including working memory."( Coppin, G; Jones-Gotman, M; Nolan-Poupart, S; Small, DM, 2014)
"Additionally, obesity has an additive effect on DMBA-induced ovarian cell death and follicle depletion, thus, we investigated in vivo impacts of obesity and DMBA on CX protein levels."( Ganesan, S; Keating, AF; Nteeba, J, 2015)
"Obesity has become a leading global health problem owing to its strong association with a high incidence of oxidative stress."( Aouani, I; Cavalier, JF; Lahbib, K; Touil, S, 2015)
"Maternal obesity has well documented effects on offspring reproduction."( Ibáñez, C; Nathanielsz, PW; Rodríguez-González, GL; Santos, M; Vega, CC; Zambrano, E, 2015)
"Obesity has been implicated in the development of many cancers."( Azzarà, A; Bruschi, F; Cabiati, M; Caselli, C; Chiaramonte, A; Del Ry, S; Facioni, MS; Giannessi, D; Guiducci, L; Mazzoni, S; Prescimone, T; Salvadori, C; Scarpato, R, 2015)
"Obesity has been recognized as a major global public health concern."( Kannan, K; Pavithran, PV; Sakthivel, S; Vasukutty, JR; Wu, Q; Xue, J, 2015)
"The prevalence of obesity has increased at alarming rates, particularly because of the increased consumption of high-fat diets (HFDs)."( Bazotte, RB; Beraldi, EJ; Buttow, NC; Ferreira, PE; Soares, A, 2015)
"Obesity has been a relative contraindication for renal transplantation."( Chapman, JR; Chung, H; Hawthorne, WJ; Lam, VWT; O'Connell, PJ; Pleass, HC; Ryan, BJ; Yuen, LPK, 2015)
"Drug treatments for obesity have proven efficacy from randomized trials, but their effectiveness in routine clinical practice is unknown."( Batterham, RL; Bhaskaran, K; Douglas, IJ; Smeeth, L, 2015)
"Obesity has been associated with high bone mineral density (BMD) but a greater propensity to fracture."( Anunciado-Koza, R; Berry, R; Doucette, CR; Horowitz, MC; Koza, RA; MacDougald, OA; Rosen, CJ, 2015)
"Obesity has been characterized by alterations in brain structure and function associated with emotion processing and regulation."( Arolt, V; Dannlowski, U; Dohm, K; Grotegerd, D; Haupenthal, C; Heindel, W; Kugel, H; Opel, N; Redlich, R, 2015)
"Obesity has reached global epidemic proportions and is associated with multiple comorbidities, including cardiovascular disease."( Kumagai, H; Maeda, S; Tanaka, K; Tsujimoto, T; Yoshikawa, T; Zempo-Miyaki, A, 2015)
"Although obesity has been viewed traditionally as a disease of excess nutrition, evidence suggests that it may also be a disease of malnutrition."( Arundel, C; Chawla, LS; Kerns, JC, 2015)
"Obesity has become a major public health challenge in recent years."( de Sá Del Fiol, F; Marciano, JJ; Marques, MC; Sant'Ana, LL; Tardelli Ferreira, AC, 2014)
"Obesity has been linked to morbidity and mortality through increased risk for many chronic diseases."( Ascaso, JF; Blesa, S; Chaves, FJ; de Marco, G; Galan-Chilet, I; Martín-Escudero, JC; Martínez-Barquero, V; Martínez-Hervas, S; Morchon, D; Morcillo, S; Real, JT; Rentero, P; Rojo, G, 2015)
"Obesity has been associated with both changes in adipose tissue lipid metabolism and inflammation."( Dale, M; de Weijer, BA; Eiden, M; Griffin, JL; Masoodi, M; Mok, CY; Pirraco, A; Serlie, MJ; van Eijk, M; Vidal-Puig, A; Virtue, S, 2015)
"Generalized obesity has been associated with cognitive decline, a process potentially mediated by adipocytokines."( Becker, JT; Brown, TT; Jacobson, LP; Lake, JE; Martin, E; Miller, EN; Munro, CA; Palella, FJ; Post, WS; Ragin, A; Sacktor, N; Vo, QT, 2015)
"Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure."( Camarillo, IG; Chang, CC; Chang, CJ; Wu, MJ; Yang, JY, 2015)
"Obesity has been associated with elevated plasma anandamide levels."( Bergman, RN; Bradshaw, H; Catalano, KJ; Chiu, JD; Chow, RH; Harrison, LN; Hsu, IR; Ionut, V; Iyer, MS; Kabir, M; Kim, SP; Kirkman, EL; Kolka, CM; Lottati, M; Richey, JM; Stefanovski, D; Woolcott, OO; Wu, Q; Zheng, D, 2015)
"Obesity has reached epidemic proportions, but little is known about its influence on the intestinal immune system."( Ahn, J; Chng, MH; Chung, J; Clemente-Casares, X; Copeland, JK; Croitoru, K; Dunn, S; Engleman, EG; Ghazarian, M; Girardin, SE; Guttman, DS; Lam, TK; Lei, H; Luck, H; Luk, CT; Philpott, DJ; Prescott, D; Rasmussen, BA; Revelo, XS; Shi, SY; Surendra, A; Tsai, S; Winer, DA; Winer, S; Woo, M, 2015)
"Obesity has emerged as one of the major health threats worldwide."( Garcia-Diaz, DF; Lopez-Legarrea, P; Martinez, JA; Quintero, P, 2014)
"The prevalence of obesity has increased worldwide at an alarming rate."( Claret, M; Ramírez, S, 2015)
"Obesity has been implicated as a significant risk factor for development of pancreatic cancer."( Chalfant, MC; Gorden, LD; Mendonsa, AM; VanSaun, MN, 2015)
"Globally, obesity has reached epidemic proportions and poses an ever increasing burden from a societal and healthpayer perspective."( Scott, LJ, 2015)
"The prevalence of obesity has dramatically increased and poses a major threat to human health."( Cui, Y; Guo, L; Li, E; Li, Y; Liu, D; Wang, Y; Zhang, X, 2016)
"Obesity has a significant effect on the cephalic spread of a spinal block (SB) due to a reduction in cerebrospinal fluid (CSF)."( Ciftci, T; Daskaya, H; İnal, V; Kepekci, AB; Yavasca, HP, 2015)
"Obesity has become one of the most important health problems facing the industrialized world, indicating that metabolic equilibrium is frequently disrupted."( Chowen, JA; Frago, LM, 2015)
"The prevalence of obesity has increased worldwide and it has been designated as a global epidemic by WHO."( Hasnain, S, 2015)
"Male obesity has been linked to subfecundity."( Li, Z; Liang, H; Wen, X; Weng, J; Xu, F; Xu, H; Yan, J; Zhang, E, 2015)
"The prevalence of obesity has increased dramatically worldwide leading to increases in obesity-related complications, such as obesity-related glomerulopathy (ORG)."( Deng, L; Fang, Q; Liang, G; Pan, Y; Tong, C; Wang, J; Wang, L; Weng, Q; Yin, H; Zhang, Y, 2015)
"Obesity has been shown to impair myocardial performance."( Cicogna, AC; de Campos, DH; de Tomasi, LC; Ferron, AJ; Jacobsen, BB; Leopoldo, AS; Lima-Leopoldo, AP; Luvizotto, Rde A; Sant'Ana, PG, 2015)
"Obesity has been shown to affect the disposition of water-soluble medications in pediatric patients."( Messinger, MM; Moffett, BS; Wilfong, A, 2015)
"Obesity has reached epidemic prevalence, and much research has focused on homeostatic and nonhomeostatic mechanisms underlying overconsumption of food."( Borgland, SL; Naef, L; Pitman, KA, 2015)
"Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries."( Choi, CH; Heo, RW; Kang, DH; Kim, H; Roh, GS; Yi, CO, 2015)
"Obesity has become a great health issue and socioeconomic burden globally in the past few decades and has afflicted Pakistan in the same way."( Hasnain, S, 2016)
"Currently, obesity has become a worldwide epidemic associated with Type 2 diabetes, dyslipidemia, cardiovascular disease and chronic metabolic diseases."( Ding, L; Li, J; Qi, M; Song, B; Tang, X; Wang, Z; Xiao, X; Yang, L; Yang, Q, 2016)
"Obesity has been associated with increased cardiovascular risk in atrial fibrillation, but little is known in elderly patients with atrial fibrillation."( Lip, GY; Senoo, K, 2016)
"Maternal obesity has been associated with adverse pregnancy outcomes such as miscarriages."( Allen, JC; Goh, JY; He, S; Malhotra, R; Tan, TC, 2016)
"Moreover, obesity has been associated with altered sensorimotor and emotional behaviors of humans and mice."( Funato, H; Kuroda, M; Oda, S; Takase, K; Tsuneoka, Y, 2016)
"Obesity has become an important global health concern as obesity-associated adiposity is supposedly related to systemic immunologic and inflammatory alterations."( Atabay, VE; Avci, B; Aydoğdu, A; Lutfioğlu, M; Sakallioglu, EE, 2017)
"Obesity has become a global epidemic disease, contributing to increases in the prevalence of type 2 diabetes."( Chen, J; Huang, C; Li, M; Ren, L; Ren, P; Wang, M; Xiang, L; Xiao, T; Xiong, L; Zhang, JV, 2016)
"Obesity has been linked to many health problems, such as diabetes."( Li, C; Li, H; Song, Y; Tang, H; Wang, H; Zhai, L; Zhang, Y; Zhao, Y; Zhong, R; Zhu, D, 2016)
"Overweight and obesity has been suggested to be well correlated with altered levels of pro-inflammatory cytokines."( Hosseinzadeh-Attar, MJ; Razmpoosh, E; Salehi, E; Shidfar, F; Shoormasti, RS; Zarrati, M, 2017)
"Obesity has reached pandemic proportions, and there is mounting evidence that environmental exposures to endocrine disrupting chemicals known as "obesogens" may contribute to obesity and associated medical conditions."( Baatz, JE; Bowers, RR; Guillette, LJ; Spyropoulos, DD; Temkin, AM, 2016)
"Obesity has become a global public health problem associated with metabolic dysfunction and chronic disorders."( Jiao, F; Ma, Y; Ou, H; Yan, X; Yan, Z; Yu, Y; Yue, Z; Zhu, X, 2016)
"Obesity has been reported as risk factor for reduced posttransplant graft and patient survival and increased delayed graft function (DGF)."( Alloway, RR; Diwan, TS; Kaiser, TE; Tremblay, S; Woodle, ES, 2016)
"Obesity has been recognized as a state of subclinical inflammation resulting in a loss of insulin receptors and decreased insulin sensitivity."( Åström, P; Färkkilä, E; Kaprio, J; Lauhio, A; Pietiläinen, KH; Pirilä, E; Rissanen, A; Salo, T; Sorsa, TA; Tervahartiala, T; Winkelmann, A, 2016)
"Lately, obesity has been associated with an increased risk of dementia."( Hyde, TM; Kleinman, JE; Larsen, A; Olesen, RH; Rungby, J; Smidt, K, 2016)
"Obesity has a substantial impact on lysophospholipid metabolism, altering the plasma lysophospholipid profile and abolishing its sensitivity to dietary n-3 PUFAs."( Arola, L; Caimari, A; Calder, PC; Childs, CE; Del Bas, JM; Miles, EA; Paras Chavez, C; Rodriguez-Naranjo, MI; West, AL, 2016)
"Obesity has been recognized as a chronic inflammatory disease that leads to decreased sexual function and sexual development disorders."( Gong, D; Huang, G; Huang, L; Li, J; Li, Y; Lin, P; Yuan, M; Zhang, J, 2016)
"The incidence of obesity has risen to epidemic proportions in recent decades, most commonly attributed to an increasingly sedentary lifestyle, and a 'western' diet high in fat and low in fibre."( Febbraio, MA; Hardy, CL; Henstridge, DC; Luong, S; O'Hehir, RE; Oh, DY; Pizzolla, A; Prickett, SR; Rolland, JM, 2016)
"People with obesity have an excess risk of amphetamine, cocaine and cannabis consumption."( Donnadieu-Rigole, H; Duny, Y; Nalpas, B; Nocca, D; Olive, L; Perney, P, 2016)
"Diet-induced obesity has been shown to alter immune function in mice, but distinguishing the effects of obesity from changes in diet composition is complicated."( Boi, SK; Buchta, CM; Francis, MB; Grobe, JL; Meyerholz, DK; Norian, LA; Pearson, NA, 2016)
"For many years, obesity has been suggested to play a role in preeclampsia."( Abebe, F; Assefa, M; Assress, M; Endeshaw, M; Menber, L; Worku, S, 2016)
"However, obesity has no significant effect on early onset of preeclampsia (AOR = 1."( Abebe, F; Assefa, M; Assress, M; Endeshaw, M; Menber, L; Worku, S, 2016)
"Obesity has become a major health concern, with a prevalence rate approaching epidemic states."( Al Ansari, A; Al Said, S; AlMalki, A; Arafa, M; Basha, M; El Bardisi, H; Jabbour, G; Khalafalla, K; Majzoub, A; Sabanegh, E, 2016)
"Obesity has become a global epidemic and public health challenge which associates with serious health issues including diabetes, cardiovascular disease, stroke, arthritis, and some types of cancer."( Liu, Y; Liu, Z; Men, L; Pi, Z; Song, F; Wei, M; Zhou, Y, 2017)
"Both aging and obesity have been shown to induce leptin-resistance."( Balaskó, M; Feller, D; Füredi, N; Gaszner, B; Lengyel, A; Mikó, A; Pétervári, E; Rostás, I; Solymár, M; Soós, S; Székely, M; Tenk, J, 2016)
"The prevalence of obesity has markedly increased and is closely related to insulin resistance."( Chung, H; Ha, E; Hong, SH; Hong, YS; Jeong, K; Lee, H; Sung, YA, 2017)
"Obesity has become a major global health challenge due to its increasing prevalence, and the associated health risk."( Bose, S; Hussain, A; Kim, H; Ko, SG; Lim, D; Song, YK; Wang, JH; Yadav, MK, 2016)
"Obesity has a complicated connection to both breast cancer risk and the clinical behaviour of the established disease."( Andò, S; Barone, I; Bonofiglio, D; Catalano, S; Giordano, C, 2016)
"Obesity has become the most common metabolic disorder worldwide."( Huang, S; Li, Y; Qin, L; Su, J; Wan, Y; Wang, Y; Wu, W; Wu, X; Xue, R; Ye, H; Zhang, L; Zhang, Q; Zhang, Z; Zhu, X, 2017)
"The prevalence of obesity has increased rapidly during recent years and has reached epidemic proportions."( Aguirre, L; Carpéné, C; Contreras, J; Fernández, M; Fernández-Quintela, A; Milton-Laskibar, I; Portillo, MP, 2016)
"Overweight and obesity have been identified as a cause of high risk diseases like diabetes and cancer."( Do, TN; Ho, KY; Phee, SJ, 2016)
"Obesity has high prevalence among HIV-infected patients."( Champenois, K; Charpentier, C; Descamps, D; Joly, V; Landman, R; Le, MP; Madelain, V; Peytavin, G; Yazdanpanah, Y; Yeni, P, 2017)
"Obesity has been associated with the excessive intake of palatable food as well as physical inactivity."( Chen, W; Li, J; Li, Q; Liu, J; Shang, NN; Tang, DH; Wang, HJ, 2017)
"Obesity has become a major threat to public health and is accompanied by chronic low-grade inflammation, which leads to various pathological developments."( Chou, MJ; Hsieh, CC; Wang, CH, 2017)
"Obesity has an adverse effect on iron status."( Cao, YQ; Gao, Q; Li, M; Wang, C; Wei, SG; Xie, XC, 2017)
"Obesity has reached epidemic proportions and is a well-recognised risk factor for venous thromboembolism (VTE)."( Hunt, BJ, 2017)
"Childhood obesity has been associated with cortisol production dysregulation."( Apostolakou, F; Christaki, E; Chrousos, GP; Papafotiou, C; Papassotiriou, I; Pervanidou, P; van den Akker, EL; Wester, VL, 2017)
"The prevalence of obesity has significantly increased in developed countries, particularly in France with an overall increase of 76% over the last 15 years."( Azaïs, H; Deruelle, P; Ghesquiere, L; Hanssens, S; Leroy, A, 2017)
"Maternal obesity has been shown to increase the risk of obesity and related disorders in the offspring, which has been partially attributed to changes of appetite regulators in the offspring hypothalamus."( Chen, H; Nguyen, LT; Pollock, C; Saad, S; Tan, Y, 2017)
"Obesity has become a serious epidemic health problem in both developing and developed countries."( Al-Bachir, M; Bakir, MA, 2017)
"Obesity has been associated with leptin resistance and this might be caused by genetic factors."( Huriyati, E; Lee, YY; Luglio, HF; Sulistyoningrum, DC; Wan Muda, WAM, 2017)
"Obesity has become a major health concern with few effective medications."( Fang, X; Gao, S; Liu, H; Ma, R; Ma, Y; Mo, F; Mu, Q; Wang, L; Wu, R; Yu, N; Zhang, D; Zhao, D; Zhu, R; Zuo, J, 2017)
"The prevalence of obesity has been increasing in recent decades and is reaching epidemic proportions."( Fernández-Quintela, A; González, M; Milton-Laskibar, I; Portillo, MP, 2017)
"Obesity has been an epidemic worldwide over the past decades and significantly increases the risk of developing a variety of deadly diseases including type 2 diabetes, cardiovascular diseases and many cancers."( Liu, W; Wang, X; Xie, X, 2017)
"Obesity has been shown to increase risk for cardiovascular disease and type-2 diabetes."( Hemphill, W; Rivera, O; Talbert, M, 2018)
"Obesity has been associated with chronic pain following TJA."( Campbell, AL; Iorio, R; Karia, R; Stuchin, SA; Yu, S, 2018)
"Maternal obesity has been related to adverse neonatal outcomes and fetal programming."( Borboa-Olivares, H; Bravo-Flores, E; Cardona-Pérez, A; Estrada-Gutierrez, G; Garcia-Latorre, E; Gonzalez-Perez, G; Guzmán-Huerta, M; Hernández-Pérez, JA; Irles, C; Montoya-Estrada, A; Perichart-Perera, O; Solis-Paredes, M; Zaga-Clavellina, V, 2017)
"Obesity has become a worldwide concern in recent years, which may cause many diseases."( Chen, C; Dong, P; Han, X; Li, Z; Wang, Y; Xue, C; Yanagita, T; Zhang, T, 2018)
"Obesity has reached epidemic proportions worldwide resulting in a serious public health problem."( Al Ali, A; Chathoth, S; Cyrus, C; Hasen, M; Ismail, MH; Vatte, C, 2018)
"Obesity has been associated with reduced dexmedetomidine clearance, suggesting impaired hepatic function or reduced hepatic blood flow."( Allende, F; Anderson, BJ; Cabrera, D; Carmona, J; Contreras, V; Cortínez, LI; Ibacache, M; Oliveros, AM; Paredes, S; Quezada, N; Ramírez, C; Rolle, A; Solari, S; Torres, J, 2018)
"Over-nutrition and obesity have been associated with impaired immunity and low-grade inflammation in humans and mouse models."( Cortese, L; Giovazzino, A; Guccione, J; Palatucci, AT; Pernice, V; Piantedosi, D; Rubino, V; Ruggiero, G; Terrazzano, G, 2018)
"Background Obesity has been implicated in impaired salivary secretion."( Alada, AR; Lasisi, TJ; Shittu, ST, 2018)
"Obesity has become a global problem due to its sharply increased prevalence and associated complications."( Guo, F; Luan, X; Sun, X; Wang, C; Wang, M; Xu, L, 2018)
"Obesity has become a global public health issue."( Chou, YC; Ho, CT; Pan, MH, 2018)
"Obesity has been linked to diminished learning success in this domain."( Horstmann, A; Kube, J; Meemken, MT; Wickner, C, 2018)
"Obesity has become a worldwide health concern."( Gill, H; Hung, A; Lenon, GB; Luo, S; Nguyen, LT; Yang, AWH; Yuen, H, 2019)
"Obesity has been identified as a risk factor for adverse outcomes of various diseases."( Chen, K; Chen, Z; Cui, H; Fang, J; Huang, C; Liu, W; Shu, G; Wang, F; Zhou, Y; Zuo, Z, 2018)
"Central obesity has been shown to negatively influence the quality of life in centrally obese persons of both sexes."( Balkrishna, A; Kala, N; Sharma, SK; Telles, S, 2018)
"Obesity has been shown to be associated with low-grade systemic inflammation, brain inflammation, and cognitive decline."( Chattipakorn, N; Chattipakorn, SC; Saiyasit, N; Sripetchwandee, J, 2018)
"Obesity has become a major health concern in modern times, as it significantly increases the risk for the development of cardiovascular diseases, type 2 diabetes mellitus, and some types of cancer."( Barrios-Correa, AA; Contreras, I; Estrada, JA, 2018)
"Rates of obesity have been growing at alarming rates, compromising the health of the world population."( Barther, NN; Bona, S; Coral, G; Fernandes, S; Guedes, RP; Marroni, NP; Porawski, M; Schemitt, E; Thoen, RU; Tovo, C, 2019)
"Obesity has reached global epidemic proportions and is associated with serious medical comorbidities and economic consequences."( Bystrowska, B; Filip, M; Kazek, G; Krośniak, M; Rospond, B; Sadakierska-Chudy, A, 2019)
"Chronic obesity has increased worldwide, in conjunction with type 2 diabetes."( Hirakawa, T; Nakadate, K; Tanaka-Nakadate, S, 2019)
"The prevalence of obesity has led the scientific community to investigate the cause of this multifactorial metabolic disorder."( Aliasghari, F; Mahdavi, R; Yaghin, NL, 2019)
"Obesity has become a major health problem worldwide and is associated with low-grade chronic inflammation and intestinal dysbiosis."( Ho, CT; Kalyanam, N; Lee, PS; Pan, MH; Teng, CY, 2019)
"Although obesity has been associated with adverse testicular function in some studies, it remains unclear whether poor testicular function merely reflects, or causes, poor metabolic health."( Adams, LA; Beilin, LJ; Dickinson, JE; Doherty, DA; Handelsman, DJ; Hart, RJ; Huang, RC; McLachlan, R; Minaee, N; Mori, TA; Norman, RJ; Olynyk, JK, 2019)
"Individuals with obesity have quadriceps dysfunction that is weakly associated with KEM during walking."( Costa, PB; Fisher, KL; Garcia, SA; Holmes, SC; Pamukoff, DN; Post, BK; Vakula, MN, 2019)
"Maternal obesity has been associated with kidney disorders in male offspring."( Chen, H; Mak, CH; Nguyen, LT; Pollock, CA; Saad, S; Wong, MG; Zaky, AA, 2019)
"The incidence of obesity has reached alarming proportions worldwide, and increasing evidence suggests that the parents' nutritional status may predispose their offspring to lipotoxic cardiomyopathy."( Adams, PD; Birse, RT; Bodmer, R; Dall'Agnese, A; Diop, SB; Guida, MC; Mai, A; Puri, PL; Toto, PC, 2019)
"Obesity has become a severe public health problem worldwide."( Fang, K; Gu, M; Luo, L, 2018)
"Human obesity has been associated with increased glycogen deposition in adipocytes."( Flores-Opazo, M; Naim, T; Stapleton, D; Trieu, J; Valladares-Ide, D; Zbinden-Foncea, H, 2020)
"Obesity has become a world-wide pandemic and is considered a major risk factor for various diseases."( Al-Tarrah, K; Jones, SW; Lord, JM; Moiemen, N, 2020)
"Obesity has reached epidemic proportions and its prevalence is climbing."( Atawia, RT; Bunch, KL; Caldwell, RB; Caldwell, RW; Toque, HA, 2019)
"Obesity has become a global health-threat for every age group."( Frederix, L; Hemmeryckx, B; Lijnen, HR; Lox, M; Scroyen, I; Vercalsteren, E; Vranckx, C, 2019)
"Obesity has many deleterious effects on the cardiovascular system, mediated by changes in insulin sensitivity, dyslipidaemia, oxidative stress and inflammation."( Costantino, S; Paneni, F, 2019)
"Obesity has been linked to an inflammation like state in the hypothalamus, mainly characterized by reactive gliosis (RG) of astrocytes and microglia."( Harrison, L; Pfluger, PT; Pfuhlmann, K; Schriever, SC, 2019)
"Youth with obesity have lower SHBG than youth with NW, but obesity has differential effects on reproductive hormones in girls versus boys, which are apparent early in puberty."( Hilkin, A; Kelsey, MM; Nadeau, KJ; Nokoff, N; Pyle, L; Santoro, N; Thurston, J; Zeitler, PS, 2019)
"The prevalence of obesity has grown exponentially over the last several decades."( Hohl, A; Rigon, FA; Ronsoni, MF; van de Sande-Lee, S, 2019)
"Obesity has been proposed as a risk factor for prostate cancer (PCa)."( Angel, CZ; Guha, N; Gunter, MJ; Huybrechts, I; Iguacel, I; McKenna, DJ; Mullee, A; Smelov, V; Wasson, R, 2020)
"The prevalence of obesity has grown rapidly over the past several decades and has been accompanied by an increase in the prevalence of chronic pain and prescription opioid use."( Ammann, EM; Berry, KM; Collins, JM; Felson, DT; Hsiao, CW; Johnston, SS; Lee, S; Lundberg, DJ; Manson, JE; Neogi, T; Scamuffa, RF; Solomon, DH; Stokes, A; Waggoner, JR, 2019)
"The prevalence of obesity has raised global concerns."( Li, P; Liang, Y; Liu, D; Ma, X; Wang, P; Zhai, W; Zhan, J; Zhou, Z, 2019)
"Obesity has been demonstrated as a disruptor of female fertility."( Chen, S; Fu, Q; Gao, P; Jiang, Q; Liu, F; Shu, G; Song, M; Su, H; Wang, L; Wang, S; Yuan, C; Zhang, F; Zheng, J; Zhu, X, 2019)
"Recently, obesity has become a common worldwide concern."( Aryaeian, N; Emami, MR; Khorshidi, M; Kord-Varkaneh, H; Mousavi, SM; Rahmani, J; Sadeghi, A; Teymouri, A; Zarezadeh, M, 2019)
"Obesity has a positive relation to non-alcoholic fatty liver disease (NAFLD) and studies have demonstrated that strength training can regulate lipid accumulation in the hepatocytes of obese rats."( de Freitas, MC; Dos Santos, GF; McCabe, J; Seraphim, PM; Teixeira, GR; Veras, ASC, 2019)
"The prevalence of obesity has increased over the past few years, becoming a public health problem."( Frandes, M; Gherbon, A; Lungeanu, D; Nicula, M; Timar, R, 2019)
"Obesity has long thought to be associated with improved bone density due to increased mechanical loading, but recent literature suggests obesity may actually decrease bone health."( Bell, A; Clayton, ZS; Hakkak, R; Hooshmand, S; Rochester, E; Simecka, C; Wickman, BE, 2019)
"Obesity has been shown to be highly associated with deterioration in executive functions, elevated energy metabolic indices and low-grade systemic inflammation."( Chen, FC; Chuang, CY; Huang, TH; Pan, CY; Tsai, CL; Tsai, MC, 2019)
"Now a day, obesity has become a chronic disorder affecting the larger population than any other disease in the world, which made its presence felt first in the Northern Hemisphere, and has now taken a pandemic look affecting practically almost all the countries of the globe."( Juyal, R; Semwal, J; Shikha, D; Srivastava, AK; Vyas, S, 2019)
"BACKGROUND Obesity has become a global public health problem."( Chen, X; Gao, L; Han, X; Wang, W; Wang, Y, 2019)
"Obesity has serious consequences such as the onset of metabolic syndrome, type 2 diabetes, atherosclerosis, or cardiovascular complications."( Bilski, R; Kupczyk, D; Pawłowska, M; Sokołowski, K; Szewczyk-Golec, K; Woźniak, A, 2019)
"The incidence of obesity has increased dramatically over the past two decades with a prevalence of approximately 40% of the adult population within the United States."( Beck, D; King, SE; Nilsson, E; Skinner, MK, 2019)
"Obesity has become a worldwide health crisis and is associated with a plethora of comorbidities."( Butter, LM; Claessen, N; El Boumashouli, C; Florquin, S; Kors, L; Leemans, JC; Ochodnicky, P; Rampanelli, E; Roelofs, JJTH; Scantlebery, AML; Teske, GJ; van den Bergh Weerman, MA, 2019)
"Diet-induced obesity has been linked to metabolic disorders such as cardiovascular diseases andtype 2 diabetes."( Medina, I; Méndez, L; Miralles-Pérez, B; Muñoz, S; Nogués, MR; Ramos-Romero, S; Torres, JL, 2019)
"Obesity has become the main health issue in developed countries as it impacts life expectancy and increases mortality of cerebrovascular or cardiovascular diseases."( Duan, DM; Hsu, LA; Jhang, JY; Ko, YL; Teng, MS; Wu, S, 2020)
"Smoking habits and obesity have jointly great impact on mortality, however mechanisms behind the effect and variables involved in the obesity paradox is still unknown."( Bäckman, L; Håglin, L; Törnkvist, B, 2020)
"The prevalence of obesity has tripled in recent decades and is now considered an alarming public health problem."( Alves, MG; de Lourdes Pereira, M; Moreira, BP; Oliveira, PF; Rato, L; Silva, JF, 2021)
"Maternal obesity has been shown to impact the offspring health during childhood and adult life."( Aisemberg, J; Bariani, MV; Beltrame, JS; Cella, M; Correa, F; Domínguez Rubio, AP; Franchi, AM; Marvaldi, C; Schander, JA; Silberman, DM, 2020)
"Obesity has emerged as the second most important metabolic risk factor for neuropathy (diabetes being the first) from consensus findings of seven observational studies in populations across the world."( Callaghan, BC; Feldman, EL; Fridman, V; Gallagher, G, 2020)
"Obesity has become a major threat to health worldwide."( Carrier, M; Wang, TF, 2020)
"Human obesity has become a global health epidemic, with few safe and effective pharmacological therapies currently available."( Arap, W; Arterburn, JB; Brigman, JL; Hathaway, HJ; Hu, C; Liu, M; Mauvais-Jarvis, F; Pasqualini, R; Prossnitz, ER; Sharma, G; Staquicini, DI, 2020)
"Obesity has been increasing globally for over three decades."( Yao, Y, 2020)
"The prevalence of obesity has increased dramatically worldwide in the past ~50 years."( Cai, GH; Chen, Y; Chu, XY; Liu, H; Liu, M; Lu, JF; Shi, XC; Wang, X; Wang, YL; Wu, JW; Xia, B; Xie, BC; Yang, SZ; Zhang, CC; Zhang, DY; Zhang, RX; Zhu, MQ, 2020)
"Obesity has been identified as being a risk factor for the development of peripheral neuropathy with other neurotoxic anticancer agents."( Moore, DC; Muslimani, A; Nix, D; Ringley, JT, 2020)
"Obesity has become a severe public health problem worldwide."( Deng, Q; Guan, Y; Huang, J; Li, G; Long, L; Si, L; Soleimani Damaneh, M, 2020)
"Midlife obesity has been associated with poor cognitive functioning in older age, but the bidirectional pathways linking the brain and excessive adipose tissue require further research."( Haley, AP, 2020)
"Obesity has been described as a global epidemic and is a low-grade chronic inflammatory disease that arises as a consequence of energy imbalance."( Giacca, A; Yung, JHM, 2020)
"The prevalence of obesity has driven searches for cognitive or behavioural economic factors related to Body Mass Index (BMI)."( Veillard, ML; Vincent, BT, 2020)
"The epidemic of obesity has become pandemic, putting a significant burden on the world's healthcare system."( Herrero, L; Mera, P; Obri, A; Serra, D, 2020)
"Ageing and obesity have common hallmarks: altered glucose and lipid metabolism, chronic inflammation and oxidative stress are some examples."( Boriek, AM; Pardo, PS, 2020)
"Obesity has become one of the most serious issues threatening the health of humankind, and we conducted this study to examine whether and how celastrol protects against obesity."( Dong, T; Du, G; Guan, Q; Hu, W; Song, L; Wang, L; Wang, X; Xia, Y, 2020)
"Obesity has been reported to induce oxidative stress, inflammation and apoptosis in the testis."( Bakar, ABA; Mohamed, M; Nna, VU; Othman, ZA; Suleiman, JB; Zakaria, Z, 2020)
"Obesity has been regarded to be protective against fracture in spite of its association with low levels of vitamin D."( Bernardini, S; Bertoli, A; Cianfarani, MA; Massoud, R; Merra, G; Morris, HA; Perrone, MA; Tarantino, U; Valentini, A, 2020)
"Obesity has been shown to have a paradoxical benefit in a number of conditions, but the long-term effects in obesity after chronic obstructive pulmonary disease (COPD) exacerbation is still unclear."( Cavallazzi, R; DeLapp, DA; Furmanek, S; Glick, C; Ramirez, JA, 2020)
"Obesity has major adverse consequences on human health contributing to the development of, among others, insulin resistance and type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, altered behavior and cognition, and cancer."( Cremonini, E; Iglesias, DE; Kang, J; Lombardo, GE; Mostofinejad, Z; Oteiza, PI; Wang, Z; Zhu, W, 2020)
"Obesity has been recognized as a low-grade, chronic inflammatory disease that leads to an increase in obesity-associated disorders, including type 2 diabetes (T2D), fatty liver diseases and cancer."( Dong, C; Luo, Y; Su, X; Tian, Y; Xie, L; Yang, L; Zhang, R; Zhao, B; Zhou, B, 2020)
"Obesity has become a global health issue, which can cause metabolic abnormalities systemically leading to increased morbidity of series diseases."( Chen, Y; Liu, F; Wen, S; Zheng, Y, 2020)
"Obesity has a negative effect on male reproductive function via several mechanisms such as inflammation and oxidative stress."( Ghaderpour, S; Ghiasi, R; Heydari, H; Keyhanmanesh, R, 2021)
"Obesity has become a worldwide pandemic and is associated with various metabolic diseases such as type 2 diabetes mellitus and non-alcoholic fatty liver disease."( Chen, X; Pei, J; Zhang, F, 2020)
"Obesity has health consequences going beyond glucose elevation."( Rendell, M, 2021)
"Many CVOTs in obesity have either failed to demonstrate a CV benefit or have been terminated prematurely because of safety issues, prompting regulatory agencies to define new requirements (based on those for CVOTs in type 2 diabetes [T2D])."( Jacob, S; Wilding, JPH, 2021)
"Obesity has become a global health problem."( Fu, J; Wang, A; Wang, H, 2020)
"Obesity has been defined using the World Health Organization (WHO) Body Mass Index (BMI) guideline, 1998."( Abd Hamid, HA; Ariaratnam, S; Ho, BK; Jane Ling, MY; Krishnapillai, AD; Mohd Yusoff, MF; Rodzlan Hasani, WS; Shariff Ghazali, S; Tohit, NM, 2020)
"Obesity has been implicated as promoting all these issues, suggesting that sustained, effective weight loss may have independent cardiovascular benefit."( Brown-Frandsen, K; Colhoun, HM; Deanfield, J; Emerson, SS; Gronning, MOL; Holst, AG; Hovingh, GK; Kahn, SE; Kushner, RF; Lincoff, AM; Lingvay, I; Marso, S; Plutzky, J; Ravn, H; Ryan, DH, 2020)
"Obesity has been related to disorders such as type-2 diabetes, non-alcoholic fatty liver disease, and cardiovascular diseases, among others, which has made of obesity the second cause of preventable death, only behind smoking."( Bravo Clemente, L; García Cordero, J; González Rámila, S; Mateos Briz, R; Sarria Ruiz, B, 2020)
"Obesity has reached pandemic proportions and is associated with severe comorbidities, such as type 2 diabetes mellitus, hepatic and cardiovascular diseases, and certain cancer types."( Diéguez, C; Fernández-Real, JM; López, M; Nogueiras, R; Rahmouni, K; Seoane-Collazo, P, 2021)
"Obesity has become an increasingly worrisome reality."( Barbagallo, F; Calogero, AE; Cannarella, R; Cimino, L; Condorelli, RA; La Vignera, S; Magagnini, MC; Mongioì, LM, 2020)
"Mild obesity has been associated with postprandial brachial artery vascular dysfunction."( Doyle-Baker, PK; Murias, JM; Reimer, RA; Soares, RN, 2021)
"Obesity has become a common rising health care problem, especially in "modern" societies."( Abdel-Mohsen, M; Adnan, D; Bishehsari, F; Engen, PA; Giron, LB; Green, SJ; Keshavarzian, A; Naqib, A; Sarrafi, S; Shaikh, M; Wilber, S, 2021)
"Obesity has emerged as a major risk factor for insulin resistance leading to the development of type 2 diabetes (T2D)."( Le Foll, C; Lutz, TA; Pretz, D; Rizwan, MZ; Tups, A, 2021)
"The prevalence of obesity has risen globally in the past four decades in both children and adults, and it accounts for the rapid increase in the prevalence of diabetes."( Koksharova, E; Mayorov, A; Menshikov, M; Parfyonova, Y; Shestakova, M; Sklyanik, I; Sorkina, E; Stafeev, I; Tumanyan, T, 2021)
"Obesity has emerged as a leading cause of death in the last few decades, mainly due to associated cardiovascular diseases."( Abdelzaher, LA; Ali, M; Bakr, MH; Desai, AA; Mali, V; Radwan, E; Sayed, SA, 2021)
"Individuals with obesity have higher concentrations of very low-density lipoprotein (VLDL) cholesterol and increased risk of myocardial infarction."( Afzal, S; Davey Smith, G; Johansen, MØ; Nielsen, SF; Nordestgaard, BG; Vedel-Krogh, S, 2021)
"Individuals with obesity have a heightened risk of developing serious comorbidities, and pharmacological treatments for people with obesity are limited."( Alba, M; Fleck, P; Frustaci, ME; Samtani, MN; Yee, J, 2021)
"Obesity has reached alarming rates worldwide."( Corbit, LH; Pierce-Messick, Z, 2021)
"Obesity has become a worldwide pandemic as well as a major contributing factor to the increasing rate of type 2 diabetes (T2D)."( Dos Santos, JM; Jones, J; Reneau, P, 2021)
"Obesity has become a worldwide health problem."( Ghosh, S; Manchala, S; Raghunath, M; Sharma, G; Singh, AK; Sinha, JK, 2021)
"The rise in obesity has fuelled the current debate of its classification as a disease."( Gafoor, AM; Haron, A; Kirubakaran, M; Nik Ritza, NM; Reynu, R; Tikfun, G; Vimal Kumar, V, 2021)
"Obesity has been recognized as a major risk factor for the development of chronic kidney disease, which is accompanied by increased renal inflammation, fibrosis, and apoptosis."( Chen, J; Feng, J; He, H; Hong, S; Hu, X; Liang, G; Luo, W; Singh, KK; Wang, Y; Yang, B; Ye, L; Yin, S, 2021)
"Obesity has become a major health problem that has rapidly prevailed over the past several decades worldwide."( Chen, W; Chen, Y; Guo, G; Liao, X; Liu, Y; Lou, F; Wang, X; Wang, Y; Wu, R; Xiang, Y; Zeng, B, 2021)
"The treatment of obesity has therefore become a goal of great clinical and social relevance."( Calogero, AE; Cannarella, R; Cimino, L; Compagnone, M; Condorelli, RA; La Vignera, S; Mongioì, LM, 2021)
"Obesity has become a relevant problem in transplantation medicine with steadily increasing numbers of obese graft recipients."( Deißler, A; Della Penna, A; Gonzalez-Menendez, I; Günther, A; Hartl, D; Kolahian, S; Königsrainer, A; Nürnberg, B; Quante, M; Quintanilla-Martinez, L; Schneiderhan-Marra, N; van Geffen, C, 2021)
"Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD)."( Chen, S; Jiao, Y; Ma, X; Shi, H; Sun, X; Wu, S; Xing, J; Yang, R; Zhang, Q; Zhang, S, 2021)
"Obesity has been associated with increased production of reactive oxygen species (ROS), which may be involved in the development of cardiovascular disease and type 2 diabetes (T2D)."( Dela, F; Flensted-Jensen, M; Gram, M; Helge, JW; Larsen, S, 2021)
"Obesity has been associated with increased severity and mortality of COVID-19."( Jadeja, V; Joshi, C; Zhou, H, 2021)
"Obesity has been variously linked to differences in brain functional connectivity in regions associated with reward, emotional regulation and cognition, potentially revealing neural mechanisms contributing to its development and maintenance."( Hall, G; MacKillop, J; McCabe, RE; McIntyre-Wood, C; Minuzzi, L; Syan, SK, 2021)
"Obesity has been recognized as a major risk factor for the development of chronic cardiomyopathy, which is associated with increased cardiac inflammation, fibrosis, and apoptosis."( Chattipakorn, N; Chen, X; Feng, J; Guan, X; Jin, L; Liang, G; Luo, W; Pavlov, VN; Samorodov, AV; Wang, M; Wang, Y; Yang, D; Ye, L; Zhuang, Z, 2021)
"Obesity has become a worldwide epidemic, caused by many factors such as genetic regulatory elements, unhealthy diet, and lack of exercise."( Bai, L; Chen, L; Hao, X; He, J; Jiang, Y; Li, X; Niu, L; Shen, L; Tang, G; Zhang, S; Zhao, Y; Zhu, L, 2021)
"Obesity has been linked to behavioral and biochemical changes, such as reduced physical activity, dysregulated dopamine metabolism, and gene expression alterations in the brain."( Erikson, KM; Fordahl, SC; Pierce, DM; Totten, MS; Wallace, CW, 2022)
"Obesity has led fatty liver disease to become the most common chronic liver disease in children worldwide."( Kohli, R; Mitsinikos, T; Mrowczynski-Hernandez, P, 2021)
"Obesity has been associated with increased reward sensitivity to food stimuli, but a few studies have addressed this issue by using odors."( Aiello, M; Cecchetto, C; Pisanu, E; Rumiati, RI; Schöpf, V, 2022)
"Obesity has been linked to dipeptidyl peptidase IV (DPPIV), an adipokine, and treatment of obese individuals with DPPIV inhibitors has been reported to prevent weight gain and improve metabolism."( Bucher, M; Kievit, P; Li, C; Maloyan, A; Montaniel, KRC; Nathanielsz, PW; Phillips, EA; Rugonyi, S; Sullivan, EL, 2022)
"Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host."( Allen, FM; Anderson, JT; Armstrong, AR; Banerjee, R; Brown, AL; Brown, JM; Buffa, JA; Burrows, A; Cook, K; Ferguson, D; Finney, C; Fung, KK; Garcia-Garcia, JC; Gliniak, CM; Goudarzi, M; Gromovsky, AD; Hazen, SL; Helsley, RN; Horak, A; Keshavarzian, A; Lusis, AJ; Mak, TD; Massey, W; McMillan, A; Mehrabian, M; Neumann, C; Orabi, D; Osborn, LJ; Sangwan, N; Schugar, RC; Swanson, G; Wang, Z; Willard, B, 2022)
"Obesity has been consistently associated with inflammation but the influence of HDL on this association remains under study."( de Dios, O; Garcés, C; Gavela-Pérez, T; Pérez-Nadador, I; Soriano-Guillén, L; Vales-Villamarín, C, 2022)
"Obesity has been known to increase the risks of breast cancer (BC) development and also to be associated with adverse clinical outcome of the patients."( Choi, MH; Harada-Shoji, N; Ishida, T; Kawai, M; Kosaka, S; McNamala, K; Miyashita, M; Nomura, M; Sasano, H; Sato, I; Shima, H, 2022)
"Obesity has become a health threat and hard enough to deal with."( Chen, W; Chen, Y; Guo, G; Huang, C; Liao, X; Liu, J; Liu, Y; Luo, Y; Wang, X; Wang, Y; Zeng, B, 2022)
"People with obesity have been found to have lower zinc (Zn) and selenium (Se) circulatory levels and abnormal thyroid function than people with normal weight."( Andreou, E; Aphamis, G; Giannaki, CD; Roupa, Z; Zavros, A, 2023)
"Overweight and obesity have become important nutrition and health problems of women aged 18−49 years in China."( Cai, S; Cheng, X; Fang, H; Guo, Q; Ju, L; Li, S; Piao, W; Wei, X; Xu, X; Yu, D; Zhao, L, 2022)
"Women with obesity have an increased risk of developing PE likely due to impaired placental development from altered metabolic homeostasis."( Alston, MC; Redman, LM; Sones, JL, 2022)
"Obesity has now been recognized as a high-risk factor for reproductive health."( Li, Y; Liu, F; Yang, T; Zhao, J, 2022)
"In the past decade, obesity has been treated with the appetite suppressants phentermine-topiramate, bupropion-naltrexone, lorcaserin, and liraglutide, and with orlistat, a drug promoting fat malabsorption."( Cernea, S; Lăcătuşu, CM; Manu, P; Rogozea, LM, 2022)
"As obesity has been associated with a poor orosensory detection of fat."( Ben Amor, N; Doggui, R; Jamoussi, H; Karmous, I; Khan, NA; Sayed Khan, A, 2022)
"Obesity has become a global epidemic, and it is a major risk factor for other metabolic disorders such as type 2 diabetes and cardiometabolic disease."( He, Y; Jiang, Y; Torres Irizarry, VC; Xu, P, 2022)
"Obesity has become a common health concern around the world."( Chen, Y; Dai, X; Guo, F; Han, Z; Li, L; Li, Z; Wang, L; Wang, Z; Wei, J; Zhang, X; Zhu, H, 2022)
"Obesity has become a prevailing health burden globally and particularly in the US."( Dengler, DG; Harikumar, KG; Miller, LJ; Sergienko, EA; Sun, Q, 2022)
"Obesity has become a very important public health problem and is increasing globally."( Al-Obaidi, ZAF; Erdogan, CS; Gemici, B; Özgün, HB; Sandal, S; Sümer, E; Yilmaz, B, 2022)
"Overweight/obesity has been recreated in mice, but most studies focus on the effects of chronic, long-term HFHS diet exposure."( Candia, AA; Gulacsi, E; Lean, SC; Lee, GCL; Sferruzzi-Perri, AN, 2022)
"Obesity has become a global epidemic."( Jin, L; Liu, J; Ma, Z; Shen, Y; Tong, H; Wu, M; Wu, Q; Wu, Y; Zhang, Y; Zuo, J, 2022)
"Obesity has been linked to vitamin D (VD) deficiency and low calcium (CAL) status."( Harahap, IA; Landrier, JF; Suliburska, J, 2022)
"Obesity has been associated with worse outcomes after ischemia in rats, triggering proinflammatory cytokine production related to the brain microvasculature."( Cardona-Gómez, GP; Gutierrez-Vargas, JA; Oluwatomilayo-Ojo, P; Perez-Corredor, PA, 2023)
"Obesity has also been shown to impair CRF; however, the effects of sarcopenia on CRF in patients with obesity and HFrEF are unknown."( Abbate, A; Arena, R; Billingsley, HE; Bressi, E; Canada, JM; Carbone, S; Chiabrando, JG; Damonte, JI; Del Buono, MG; Halasz, G; Kadariya, D; Kim, Y; Markley, RR; Mbualungu, J; Medina de Chazal, H; Mihalick, V; Trankle, CR; Turlington, J; Van Tassell, BW; Vecchié, A, 2022)
"Obesity has become an alarming situation for society, and it has to be treated."( Bulus, H; Keskin, M; Koca, AO; Öztürk, D, 2022)
"Obesity has been reported to be associated with frailty and coronary artery disease (CAD)."( Alhusban, IM; Hayajneh, AA; Rababa, M, 2022)
"Obesity has become one of the most serious public health problems worldwide, and an increasing number of studies indicate that the gut microbiota can affect host metabolism."( Cheng, RY; He, F; Liang, HJ; Luo, YT; Miao, ZH; Qi, SH; Shen, X; Wang, JN; Wang, SJ; Zhou, QQ, 2022)
"Obesity has reached epidemic proportions, with major economic and health implications."( Ali, SA; Behare, PV; Kaul, G; Rani, K, 2022)
"The prevalence of obesity has increased dramatically in recent decades worldwide."( Cyr-Yombi, J; Dupont, E, 2022)
"Abdominal obesity has been associated with an increased risk of insulin resistance, metabolic syndrome, and diabetes."( Abarca-Arroyo, JA; Albuja-González, EC; Catzin-Kuhlmann, A; Cuevas-Ramos, D; Espinosa-Salazar, HD; García-Bonilla, HA; Gómez-Pérez, FJ; Gómez-Sámano, MÁ; Guerrero-Castillo, AP; Gulias-Herrero, A; León-Suárez, A; López-Gatell, H; Telich-Tarriba, JE; Tlapanco-Beltrán, CA; Vera-Zertuche, JM; Villanueva-Gómez-Crespo, MT, 2023)
"Abdominal obesity has been associated with an increased risk of insulin resistance, metabolic syndrome, and diabetes."( Abarca-Arroyo, JA; Albuja-González, EC; Catzin-Kuhlmann, A; Cuevas-Ramos, D; Espinosa-Salazar, HD; García-Bonilla, HA; Gómez-Pérez, FJ; Gómez-Sámano, MÁ; Guerrero-Castillo, AP; Gulias-Herrero, A; León-Suárez, A; López-Gatell, H; Telich-Tarriba, JE; Tlapanco-Beltrán, CA; Vera-Zertuche, JM; Villanueva-Gómez-Crespo, MT, 2023)
"Abdominal obesity has been associated with an increased risk of insulin resistance, metabolic syndrome, and diabetes."( Abarca-Arroyo, JA; Albuja-González, EC; Catzin-Kuhlmann, A; Cuevas-Ramos, D; Espinosa-Salazar, HD; García-Bonilla, HA; Gómez-Pérez, FJ; Gómez-Sámano, MÁ; Guerrero-Castillo, AP; Gulias-Herrero, A; León-Suárez, A; López-Gatell, H; Telich-Tarriba, JE; Tlapanco-Beltrán, CA; Vera-Zertuche, JM; Villanueva-Gómez-Crespo, MT, 2023)
"The prevalence of obesity has risen dramatically over recent years, and so has the prevalence of adverse obesity-associated pregnancy outcomes."( Chen, YC; Chiu, CF; Huang, SY; Kang, L; Sun, R; Wang, CT; Wu, HT, 2023)
"The prevalence of obesity has risen dramatically over recent years, and so has the prevalence of adverse obesity-associated pregnancy outcomes."( Chen, YC; Chiu, CF; Huang, SY; Kang, L; Sun, R; Wang, CT; Wu, HT, 2023)
"The prevalence of obesity has risen dramatically over recent years, and so has the prevalence of adverse obesity-associated pregnancy outcomes."( Chen, YC; Chiu, CF; Huang, SY; Kang, L; Sun, R; Wang, CT; Wu, HT, 2023)
"Obesity has a negative impact on both general health and oral health."( Elangovan, R; Mahendra, J; Saketharaman, P; Selvakumar, J; Sivsankar, P; Suresh, S, 2022)
"Obesity has a negative impact on both general health and oral health."( Elangovan, R; Mahendra, J; Saketharaman, P; Selvakumar, J; Sivsankar, P; Suresh, S, 2022)
"Beside the fact, obesity has psychological impacts it act as a signal of depression by stimulating endogenous stress stimulation."( Arshad, M; Farhan, M; Rafi, H; Rafiq, H; Rehman, S, 2022)
"Beside the fact, obesity has psychological impacts it act as a signal of depression by stimulating endogenous stress stimulation."( Arshad, M; Farhan, M; Rafi, H; Rafiq, H; Rehman, S, 2022)
"Obesity has become an increasingly serious health issue with the continuous improvement in living standards."( Li, X; Li, Y; Liang, H; Liu, K; Liu, S; Ma, Z; Wang, Y; Wu, C; Xiao, Y; Yu, J; Zhou, L, 2023)
"Obesity has become an increasingly serious health issue with the continuous improvement in living standards."( Li, X; Li, Y; Liang, H; Liu, K; Liu, S; Ma, Z; Wang, Y; Wu, C; Xiao, Y; Yu, J; Zhou, L, 2023)
"Obesity has been demonstrated to be an aggravating factor in the pathogenesis of asthma."( Gómez-Bastero, A; Jiménez-Cortegana, C; Novalbos-Ruiz, JP; Sánchez-Margalet, V; Sánchez-Ortega, H; Soto-Campos, JG, 2022)
"Obesity has been linked to altered reward processing but little is known about which components of reward processing including motivation, sensitivity and learning are impaired in obesity."( Bağcı, B; Bahtiyar, G; Bayrakcı, A; Düsmez, S; Heinz, A; Isıklı, S; Sebold, M; Zorlu, N, 2023)
"Obesity has been proposed as an independently risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown."( Boronat, M; Brito-Casillas, Y; Melián, C; Pérez-López, L; Santana, A; Wägner, AM, 2023)
"Obesity has been proposed as an independent risk factor for chronic kidney disease (CKD) in people, but its role in feline kidney function is unknown."( Boronat, M; Brito-Casillas, Y; Melián, C; Pérez-López, L; Santana, A; Wägner, AM, 2023)
"Although obesity has become a significant problem in transplantation medicine, the impact of different immunosuppressive protocols on clinical outcomes in obese transplant recipients remains unclear."( Beer-Hammer, S; Della Penna, A; Guthoff, M; Heyne, N; Königsrainer, A; Martus, P; Nadalin, S; Quante, M; Serna-Higuita, LM, 2023)
"Obesity has become a worldwide burden and is associated with severe medical complications."( Feng, Y; Fu, Y; Huang, H; Li, J; Liu, X; Meng, X; Wang, X; Yu, B; Zhou, X, 2023)
"Obesity has recently emerged as one of the most severe health concerns."( Ali, M; Kafle, A; Khatoon, N; Mallah, MA; Naveed, M; Noreen, S; Soomro, T, 2023)
"Obesity has been a common phenomenon worldwide that increases the risk of EC."( Fan, X; Huang, P; Li, H; Wang, Y; Xue, F; Yu, H; Zhang, K, 2023)
"It is known that obesity has a multifactorial etiology that involves genetic and environmental factors."( de Freitas, JA; de Miranda, DA; de Oliveira, DR; de Souza, E; Escamilla-Garcia, A; Nehmi-Filho, V; Otoch, JP; Palace-Berl, F; Pessoa, AFM; Santamarina, AB; Trarbach, EB, 2022)
"Cat obesity has become a serious problem that affects cats' lives and welfare."( Dang, H; Huang, Y; Ren, Y; Shan, T; Wang, Y; Zhang, S, 2023)
"The onset of obesity has been greatly associated with the appetite-regulating hormones that control, regulate, and suppress hunger, satiety, or energy expenditure."( Aadil, RM; Fernández-Lázaro, D; Jan, H; Munir, S; Rabail, R; Shehzad, A, 2023)
"The prevalence of obesity has increased in children with T1D and may confer additional CVD risk."( Chakravarthy, V; Chambers, MA; Cielonko, LA; Lutz, N; Mullen, J; Newbern, D; Olson, M; Sabati, AA; Schmidt, J; Shaibi, GQ; Swing, E, 2023)
"Obesity has been shown to be associated with low levels of soluble receptor for advanced glycation end products (sRAGE)."( Flores-Ramírez, AG; Garay-Sevilla, ME; Ibarra-Reynoso, LDR, 2023)
"Obesity has been associated with cognitive impairments, increasing the probability of developing dementia."( Aboudeya, HM; El-Hamshary, SA; El-Sebeay, AS; Hafez, LM; Ibrahim, FAR; Matar, NA; Nomair, AM; Nomeir, HM, 2023)
"Obesity has become a leading worldwide pandemic, associated with serious health outcomes."( Barrea, L; Camajani, E; Caprio, M; Colao, A; Marina, L; Muscogiuri, G; Savastano, S; Šojat, AS; Verde, L, 2023)
"The influence that obesity has on the specific mechanisms that may be involved and the potential associations with abnormal conditions in pregnancy are still poorly understood."( Bartha, I; Bartha, JL; Cuerva, M; Joumady, I, 2023)
"Obesity has been linked to a higher risk of pancreatic cancer."( Dai, S; Gao, H; Gao, Y; Jiang, K; Li, M; Lu, Z; Miao, Y; Wang, G; Yin, L; Zhang, J; Zhang, K, 2023)
"Obesity has been linked with numerous health issues as well as an increased risk of breast cancer."( Amens, JN; Bahçecioğlu, G; Dwyer, K; Hilliard, TS; Stack, MS; Yue, XS; Zorlutuna, P, 2023)
"Obesity has emerged as one of the most challenging worldwide problems and, if left untreated, can lead to major illnesses and consequences that can impair patients' health The study's objective was to evaluate the effectiveness of Liraglutide 3."( Al Qahtani, AM; AlFaris, N; Alshehri, A; Shams, M; Yahia, M, 2023)
"Obesity has been recognized as one of the most significant risk factors for the deterioration and mortality associated with COVID-19, but the significance of obesity itself differs among ethnicity."( Ainai, A; Hasegawa, H; Hirakawa, A; Hosoya, T; Iwai, H; Kamiya, M; Kanno, T; Kataoka, M; Kawata, D; Komiya, Y; Mitsui, Y; Miyamoto, S; Miyazaki, Y; Oba, S; Otomo, Y; Sato, H; Satoh, T; Suzuki, T; Tobiume, M; Wakabayashi, K; Yamada, T; Yasuda, S, 2023)
"Obesity has become a global concern because of increasing the risk of many diseases."( Ismayi, A; Kerem, G; Liu, C; Ren, PG; Teng, B; Tohty, D; Udduttula, A; Yu, X; Yu, Z; Zhang, JV, 2023)
"In addition, obesity has been associated with a poor prognosis, an increased risk of metastasis and mortality, and resistance to anti-cancer therapies."( Akrout, R; Ayed, K; Bacha, D; Boussen, H; Gati, A; Gorrab, A; Mrizak, H; Nabi, L, 2023)
"Obesity has also been linked to neurological diseases such as cognitive decline, dementia, and Alzheimer's disease (AD), caused by oxidative stress, pro-inflammatory cytokines, and the production of reactive oxygen free radicals (ROS)."( Buttar, HS; Kaur, G; Kothawade, SM; Tuli, HS, 2023)
"Obesity has been linked to numerous health and nutritional problems, including impaired iron metabolism, a common cause of anemia."( Aguree, S; Hawkins, M; Owora, A; Reddy, MB, 2023)
"Obesity has become a major health issue in dogs."( Bhatnagar, S; Pan, Y; Spears, JK; Xu, H, 2023)
"Obesity has become a major health issue in dogs and increases the risk of many chronic diseases and chronic low-grade inflammation."( Bhatnagar, S; Pan, Y; Spears, JK; Xu, H, 2023)
"on obesity have not been explored."( An, HJ; Cha, YY; Heo, I; Kim, HY; Lee, J; Park, YJ; Shin, S, 2023)
"However, obesity has an independent deleterious impact on improvement in blood pressure post-adrenalectomy for PA."( Chidambaram, S; Damji, S; Di Marco, AN; Meeran, K; Palazzo, F; Todd, J; Van Den Heede, K; Wernig, F, 2023)
"Obesity has become one of the major public health problems in both the developing and developed countries."( Che, H; Deng, Y; Huang, Y; Lao, J; Tang, Z; Wang, Y; Xu, C; Xu, H; Yin, H, 2023)
"Obesity has become a common global problem."( Fallah, M; Ghaffarian-Ensaf, R; Gholami, F; Mirzaei, K; Nemati, M; Rasaei, N, 2023)
"Obesity has been associated with a high risk of BC development."( Ajabnoor, GMA, 2023)
"Obesity has emerged as a worldwide metabolic disease, given its rapid growth in global prevalence."( Ding, L; Huang, W; Li, L; Li, W; Liu, L; Luo, Y; Wang, R; Wang, X; Wang, Z; Yang, L; Zhuang, T, 2023)
"Overweight and obesity have reached epidemic proportions and safe treatments are needed to heal these diseases."( Cazzola, R; Cestaro, B; Della Porta, M; Gasparri, C; Lombardoni, F; Nichetti, M; Patelli, Z; Perna, S; Pistolesi, E; Rondanelli, M, 2023)
"Obesity has become a major health crisis in the past decades."( Chen, W; Chen, Y; Huang, C; Liao, X; Liu, Y; Luo, Y; Wang, X; Wang, Y; Zeng, B, 2023)
"Sarcopenic obesity has steadily increased as the aging population has grown and is an increasing public health burden."( Jin, H; Lee, BY; Oh, HJ, 2023)
"Obesity has been recognized as a key risk factor for multiple metabolic disorders, including diabetes, cardiovascular diseases and many types of cancer."( Ge, GB; Hou, J; Hou, XD; Jiang, MF; Liu, W; Tang, H; Wang, L; Zhang, M, 2023)
"Adults with obesity have a reduction in branched-chain amino acid (BCAA) levels following metabolic and bariatric surgery (MBS), which is hypothesized to contribute to the metabolic advantages of MBS."( Becetti, I; Bredella, MA; Lauze, M; Lee, H; Misra, M; Singhal, V, 2023)
"The prevalence of obesity has increased, with excessive consumption of high-fat foods being one of the primary causes."( Bertoncini-Silva, C; Carlos, D; de Paula, NA; Fassini, PG; Guimarães, JB; Pereira, ÍS; Ramalho, LNZ; Rodrigues Giuliani, M; Suen, VMM, 2023)
"Obesity has become a worldwide health challenge and commonly results from the intake of more calories than the body requires."( Heisler, LK; Najm Al-Halboosi, DA; Savchenko, O; Sylantyev, S, 2023)
"More recently obesity has also been linked to changes in the brain that are associated with age-related dementia and cognitive decline."( Bethlehem, RAI; Bullmore, ET; Cercignani, M; Dear, R; Dipasquale, O; Harrison, NA; Kitzbichler, MG; Martins, D; Romero-Garcia, R; Seidlitz, J; Turkheimer, F; Warrier, V, 2023)
"Obesity has been linked to cognitive decline and adverse effects on brain health."( de Vargas, LDS; Dorneles, GP; Fontoura, JR; Guedes, RP; Jantsch, J; Peres, A, 2023)
"Obesity has a major socio-economic health impact."( Chaldakov, GN; Chiodi, V; Domenici, MR; Lelouvier, B; Lo Re, O; Micale, V; Rappa, F; Vinciguerra, M, 2023)
"Obesity has been associated with an adverse prognosis and reduced efficacy of endocrine therapy in patients with hormone receptor-positive (HR+) breast cancer (BC)."( de Graaf, H; de Roos, WK; Erdkamp, FLG; Geurts, SME; Honkoop, AH; Imholz, ALT; Kroep, JR; Lammers, SWM; Linn, SC; Smidt, ML; Smorenburg, CH; Swinkels, ACP; Tjan-Heijnen, VCG; van der Sangen, MJC; van Hellemond, IEG; Vriens, IJH, 2023)
"Individuals with obesity have higher rates of incident cardiovascular disease."( Bramante, CT; Elmaleh-Sachs, A; Gudzune, KA; Jay, M; Nicklas, JM; Schwartz, JL, 2023)

Actions

ExcerptReference
"Obesity affects the efficacy of metoprolol and isradipine in reducing blood pressure."( Gatzka, C; Rüddel, H; Schächinger, H; Schmieder, RE; Schobel, H, 1993)
"In addition to OSA, obesity may affect these variables and may have been responsible for our findings."( Bruce, EN; Gordon, EA; Hudgel, DW; Thanakitcharu, S, 1998)
"Obesity impacts on reproductive function in man and women."( Albero Gamboa, R; Guallar Labrador, AM; Sanz París, A, 1999)
"Abdominal obesity affects many aspects of women's health, and recent studies indicate that hyperandrogenicity (HA) may contribute to the excess of body fat in women."( Baghei, F; Björntorp, P; Holm, G; Rosmond, R, 2000)
"Obesity affects a large population of industrialised countries in which occurrence may reach 20%."( Beal, P; Boulanger, M; Boussard, MF; Della-Zuana, O; Duhault, J; Fournier, J; Guette, JP; Wierzbicki, M, 2000)
"In patients with obesity, SH affects energy expenditure only when TSH is clearly above the normal range; it does not change body composition and lipid profile."( Berselli, ME; Calò, G; Liuzzi, A; Minocci, A; Petroni, ML; Savia, G; Tagliaferri, M; Viberti, GC, 2001)
"Because obesity can affect catecholaminergic signaling, we determined the effects of i."( Billes, SK; Cowley, MA, 2007)
"Obesity affects cardiovascular risk and also quality of life (QoL)."( Bissoli, L; Bosello, O; Cancelli, F; Di Francesco, V; Mazzali, G; Minniti, A; Sacco, T; Salanitri, T; Zamboni, M; Zoico, E, 2007)
"In conclusion, obesity may affect the pathophysiology of type 2 diabetes by upregulating genes involved in OXPHOS in association with insulin resistance markers and the expression of genes involved in hepatic gluconeogenesis and ROS generation."( Ando, H; Honda, M; Kaneko, S; Kurita, S; Matsuzawa-Nagata, N; Misu, H; Ota, T; Sakurai, M; Shimizu, A; Takamura, T; Takeshita, Y, 2008)
"Maternal obesity affects offspring weight, body composition, and organ function, increasing diabetes and metabolic syndrome risk."( Ford, SP; Hess, BW; Miller, MM; Moss, GE; Nathanielsz, PW; Nijland, MJ; Smith, DT; Zhang, L; Zhu, M, 2009)
"Studies about how obesity affects asthma control and lung function show conflicting results."( Dixon, AE; Hossain, J; Lang, JE; Lima, JJ; Peters, SP; Shade, D; Wise, RA, 2011)
"Obesity affects postural sway during normal quiet standing; however, the reasons for the increased postural sway are unknown."( Berrigan, F; Corbeil, P; Handrigan, GA; Hue, O; Simoneau, M; Teasdale, N; Tremblay, A, 2012)
"Obesity can impact on reproductive functions by causing hormonal imbalance and ovulatory dysfunction."( Al-Nuaim, LA, 2011)
"Morbid obesity affects the pharmacokinetics and pharmacodynamics of anesthetics, which may result in inappropriate dosing."( Britton, SL; Koch, LG; Lipinski, WJ; Lydic, R; Mashour, GA; Pal, D; Walton, ME, 2012)
"To determine how obesity affects disease characteristics in a diverse cohort of children with poorly controlled asthma, and if obesity effects are altered by sex."( Dixon, AE; Holbrook, JT; Irvin, CG; Lang, JE; Lima, JJ; Shade, D; Teague, WG; Wei, CY; Wise, RA, 2013)
"Obesity affects the vitamin D status in humans."( Itariu, BK; Leitner, L; Marculescu, R; Stulnig, TM; Zeyda, M, 2013)
"Obesity impacts outcome in women with epithelial ovarian cancer (EOC), although its exact role and the molecular mechanisms remain poorly defined."( Diaz, ES; Karlan, BY; Li, AJ, 2013)
"Little is known how obesity affects the management of CVD."( Chudek, J; Kocełak, P; Owczarek, A; Ziaja, D; Ziaja, K, 2013)
"In conclusion, obesity affects age-associated alterations in gene expression in both epididymal and bone marrow adipocytes regardless of diet or genetic background."( Azhar, S; Kraemer, FB; Liu, LF; Patel, S; Shen, WJ; Ueno, M, 2013)
"Obesity impacts reproductive ability, adversely affecting conception and leading to complications in pregnancy."( Arck, PC; Douglas, AJ; Parker, VJ; Solano, ME, 2014)
"Maternal obesity affects the incidence of cardiovascular disease and diabetes in offspring."( Coffman, KL; Foote, C; Ji, T; Martinez-Lemus, LA; Ramirez-Perez, FI; Rivera, RM; Schenewerk, AL, 2014)
"Obesity can affect chondrocyte physiology; adipokines, insulin and proinflammatory cytokines levels are all altered in the obese and are related to matrix turnover impairments and thus to osteoarthritis."( López-Zapata, DF; Sánchez, JC; Wilkins, RJ, 2014)
"Childhood obesity affects nearly 17% of children and adolescents in the United States."( Davis, EP; Espel, EV; Glynn, LM; Sandman, CA; Stout, SA, 2015)
"Obesity affects 18% of U."( Keim, SA; Klebanoff, MA, 2015)
"As obesity may affect the efficacy of some contraceptives, we examined weight, body mass index (BMI) and prevalence of obesity among female contraceptive clients at 231 U."( Kohn, JE; Lopez, PM; Simons, HR, 2015)
"HFD and obesity can affect sperm parameters and spermatogenesis and antioxidants consumption may improve their quality."( Mohammadi Roushandeh, A; Mortazavi, M; Salehi, I, 2015)
"Furthermore, obesity affects almost all body systems including the extracellular matrix (ECM) by generating a pro-inflammatory environment, which are associated with abnormal secretions of several cytokines or hormonal substances, for example, insulin-like growth factors (IGFs), leptin, and sex hormones."( Barreto, SC; Bhowmick, M; Hopkins, CA; Ray, A, 2015)
"Obesity can affect the clinical course of a number of diseases, including breast cancer in women and mammary gland tumors in female dogs, via the secretion of various cytokines and hormones."( Im, KS; Kim, HW; Kim, NH; Lim, HY; Shin, JI; Sur, JH; Yhee, JY, 2015)
"Obesity affects male infertility by influencing the hypothalamic-pituitary-gonadal axis, thus causing detrimental effects upon spermatogenesis and subsequent fertility."( Coward, K; Davidson, LM; Fatum, M; Jones, C; Millar, K, 2015)
"Maternal obesity affected the expression of bitter taste receptors and other genes in the heart ventricle, potentially implicating these genes in the development of CVD associated with maternal obesity."( Bahari, H; Hardy, GO; Morris, MJ; Raipuria, M, 2015)
"Total body obesity affected headache frequency, intensity, and duration, while leptin levels did not."( Chunfu, C; Congcong, L; Jinjin, Q; Ligong, Z; Xiaojun, D, 2015)
"Obesity affects an increasing number of individuals in the human population and significant importance is attached to research leading to the discovery of drug which would effectively reduce weight."( Bednarski, M; Dudek, M; Głuch-Lutwin, M; Kazek, G; Knutelska, J; Kulig, K; Mordyl, B; Nowiński, L; Sapa, J; Zaręba, P; Zygmunt, M, 2016)
"How obesity affects the response to sepsis was not completely understood."( Kaplan, JM; Lahni, P; Nowell, M; Shanmukhappa, SK; Shen, H; Zingarelli, B, 2016)
"Obesity affects all social classes, making it necessary to develop effective products that aid weight loss or help prevent weight gain."( Gambero, A; Macedo, GA; Moreira, DK; Santos, PS, 2017)
"Obesity affects millions of people worldwide, constituting a public health problem associated with premature mortality."( Barragán-Álvarez, CP; Diaz-Martinez, NE; Flores-Fernández, JM; Padilla-Camberos, E; Rathod, V, 2018)
"Obesity may affect activity and/or expression of enzymes participating in xenobiotics' detoxification and antioxidant defense."( Bártíková, H; Boušová, I; Košťáková, Š; Matoušková, P; Skálová, L; Szotáková, B, 2017)
"Obesity affects this process and results in changes in the size and cellular make-up of the tissue, but it remains unknown if there are sex differences in obesity-induced alterations in IESC proliferation and differentiation."( Dailey, MJ; Davis, EA; Li, K; Nowak, RA; Zhou, W, 2018)
"Maternal obesity impacts fetal growth as early as second trimester of pregnancy, yet little is known about the molecular mechanisms involved."( Chen, J; Hinkle, SN; Liu, D; Rawal, S; Tsai, MY; Zhang, C, 2019)
"Obesity affected the periodontal conditions, the alveolar bone pattern, and the salivary leptin concentration."( Bonato, RCS; Chaim, EA; Groppo, FC; Haiter-Neto, F; Sales-Peres, MC; Sales-Peres, SHC, 2019)
"Obesity affected sleep-related parameters but hyperandrogenism had no effect."( Carneiro, G; Hachul, H; Pereira, AZ; Polesel, DN; Tock, L; Togeiro, SM; Tufik, S; Zanella, MT, 2019)
"Determining how obesity affects function in human myometrial arteries, to help understand why childbirth has poor outcomes in obese women."( Prendergast, C; Wray, S, 2019)
"In addition, obesity may affect Endothelium-Dependent Hyperpolarization (EDH), which drives vasorelaxation in small resistance arteries and arterioles."( Berra-Romani, R; Faris, P; Moccia, F; Negri, S, 2020)
"With epidemic of obesity, it affects aspects of female reproduction."( Huang, D; Li, F; Liu, X; Xie, J; Xie, M, 2020)
"Maternal obesity impacts offspring metabolism."( Chowdhury, SS; Hagan, C; Morris, MJ; Sinclair, DA; Uddin, GM; Youngson, NA, 2020)
"Obesity affecting drug pharmacokinetics results in the risk of the therapeutic failure or toxic side effects of drugs increasing."( Duan, Y; Li, B; Ma, X; Saad, AAA; Tian, H; Wang, X; Wei, Y; Wu, X; Zhang, F; Zhang, J, 2020)
"Maternal obesity, affecting nearly 1 in 4 pregnancies, is associated with increased circulating saturated fatty acids, such as palmitate."( Aronoff, DM; Eastman, AJ; Gaddy, JA; Moore, RE; Townsend, SD, 2021)
"Additionally, obesity can affect pharmacodynamic properties, such as the 50% of maximal effective concentration and the effect-site equilibration rate constant (ke0)."( Kim, TK, 2021)
"Donor obesity affects the incidence of delayed graft function, but not the incidence of acute rejection in recipients."( Bellini, MI; Knight, S; Nozdrin, M; Papalois, V; Pengel, L, 2022)
"Today, obesity affects over one-third of the global population and is hugely considered the Industrial Revolution's side effect."( Benchoula, K; Hwa, WE; Parhar, IS; Vohra, MS, 2022)
"Paternal obesity impacts sperm H3K4me3 and is associated with placenta, embryonic and metabolic outcomes in descendants."( Dumeaux, V; Kimmins, S; Lafleur, C; Lambrot, R; Pepin, AS, 2022)
"Obesity affects more than one-third of adults in the U."( Asanza, E; Bredella, MA; Deckersbach, T; Eddy, KT; Holmes, TM; Holsen, LM; Kerem, L; Kheterpal, A; Lawson, EA; O'Donoghue, ML; Plessow, F; Soukas, AA; Stanford, FC; Torriani, M; Vangel, M; Wronski, ML, 2022)
"While obesity can affect brain function, consumption of select dietary bioactives may help prevent obesity-related cognitive decline."( Cremonini, E; Kang, J; Le Gall, G; Muller, M; Oteiza, PI; Pontifex, MG; Vauzour, D; Wang, Z, 2022)
"Although obesity affects the relation between beta-amyloid (Aβ) aggregation and cognitive decline, the longitudinal interactive effect of adipokines and Aβ on cognition and brain structures in humans remains unexplored."( Cho, SY; Ha, J; Kim, E; Kim, H; Kim, KY; Kim, M, 2022)
"Pre-pregnancy obesity can affect pregnant and newborn gut microbiota, which might related to fetal growth of the newborn."( Akpinar, F; Cömert, TK; Durmaz, B; Durmaz, R; Erkaya, S, 2022)
"Pre-pregnancy obesity can affect pregnant and newborn gut microbiota, which might related to fetal growth of the newborn."( Akpinar, F; Cömert, TK; Durmaz, B; Durmaz, R; Erkaya, S, 2022)
"Pre-pregnancy obesity can affect pregnant and newborn gut microbiota, which might related to fetal growth of the newborn."( Akpinar, F; Cömert, TK; Durmaz, B; Durmaz, R; Erkaya, S, 2022)
"Obesity affects more than a third adult population in the United States; the prevalence is even higher in patients with major depression disorders."( Arzola, EP; Liu, F; Mei, L; Santiago-Marrero, I; Wang, H; Xiong, WC, 2023)
"Obesity, affecting one in three pregnant women worldwide, is not only a major obstetric risk factor."( Andersen, HHB; Larsen, A; Pedersen, LH; Volqvartz, T, 2023)
"Obesity affects approximately 42% of US adults and is associated with increased rates of type 2 diabetes, hypertension, cardiovascular disease, sleep disorders, osteoarthritis, and premature death."( Bramante, CT; Elmaleh-Sachs, A; Gudzune, KA; Jay, M; Nicklas, JM; Schwartz, JL, 2023)
"Obesity affects approximately 42% of adults in the US."( Bramante, CT; Elmaleh-Sachs, A; Gudzune, KA; Jay, M; Nicklas, JM; Schwartz, JL, 2023)

Treatment

ExcerptReference
"Results obtained in the treatment of obesity with chorionic gonadotropin and a 500 calorie standard diet are presented."( Candi, L; Davi, D; Fabbri, F; Vallini, A, 1976)
"Since any drug treatment of obesity interferes with the patient's motivation to subject himself to the prolonged and possibly life-long changes in his eating habits and exertional behavior which are mandatory for the achievement of long-term therapeutic success, the use of drugs is rarely indicated in the treatment of obesity and should remain the exception."( Stauffacher, W, 1975)
"Pharmacological treatment of obesity has evolved in recent years with the development and licensing of potent serotonin agonists, such as dexfenfluramine (D-F)."( Finer, N, 1992)
"Pharmacological treatment of obesity has evolved in recent years with the development and licensing of potent serotonin agonists, such as dexfenfluramine (dF), acting as nonstimulant anorectic agents."( Finer, N; Finer, S; Naoumova, RP, 1992)
"The long-term results of dietary treatment for obesity are often very poor."( De Leeuw, I; Van Acker, K; Van Gaal, L; Vansant, G, 1991)
"To determine its efficacy and safety in treating obesity, a silicone-rubber balloon was passed into the stomach of 10 nondieting, obese subjects."( Gage, D; Geliebter, A; Hashim, SA; McCray, RS; Melton, PM, 1990)
"No single diet exists for the treatment of obesity."( Balabanski, L, 1985)
"Although treatment of obesity by weight loss decreases blood pressure substantially, a minority of patients do not respond to the weight loss."( Berchtold, P; Berger, M; Horton, ES; Sims, EA, 1983)
"The goal of the dietary treatment of obesity is to reduce the patient's weight with minimum risk."( Blackburn, GL, 1984)
"Drastic methods for the treatment of obesity are critically reviewed."( Berchtold, P; Berger, M; Gries, FA; Zimmermann, H, 1980)
"Ninety-two patients in long-term treatment for obesity completed a questionnaire on the weight development of their close family members."( Franson, K; Rössner, S, 1994)
"It may be presumed that in the treatment of obesity, in addition to the use of serotoninergic drugs, successes with reducing diets may be enhanced by including periods of high-carbohydrate, low-protein intake."( Noach, EL, 1994)
"Orlistat can be used for the treatment of obesity."( Drent, ML; van der Veen, EA, 1993)
"Future studies on treatment of obesity should include consideration of regional fat distribution."( Andresen-Reid, ML; Jensen, MD; Kanaley, JA; Kottke, BA; Oenning, L, 1993)
"Pharmacological treatment of obesity has been neglected as a viable therapeutic option for many years."( Atkinson, RL; Blank, RC; Loper, JF; Lutes, RA; Schumacher, D, 1995)
"This article focuses on the treatment of obesity and potential results."( Blackburn, GL; Chan, S; Miller, D, 1997)
"Low caloric diet is a commonly accepted treatment in obesity."( Hartleb, M; Janusz, M; Karpel, E; Nowak, A; Waluga, M, 1998)
"Severe energy restriction in the treatment of obesity is limited by catabolism of body protein stores and, consequently, loss of lean as well as fat tissue."( Berselli, ME; Cavagnini, F; Dubini, A; Montesano, A; Ortolani, S; Pincelli, AI; Scacchi, M; Silvestri, P; Tagliaferri, M, 1998)
"The future of the pharmacologic treatment of obesity is promising."( Aronne, LJ, 1998)
"Conventional treatment of obesity reduces fat in mature adipocytes but leaves them with lipogenic enzymes capable of rapid resynthesis of fat, a likely factor in treatment failure."( Higa, M; Newgard, CB; Unger, RH; Wang, ZW; Zhou, YT, 1999)
"The main indication for operative treatment is morbid obesity (body mass index greater than 40 kg/m2) or severe obesity (body mass index > 35 kg/m2) with comorbidities of obesity."( Uusitupa, M, 1999)
"Outpatient's Service for Prevention and Treatment of Obesity at the University Hospital."( Allegra, A; Buemi, M; Calapai, G; Ceruso, D; Corica, F; Corsonello, A; Nicita Mauro, V; Ruello, A, 1999)
"Orlistat as a treatment for obesity, when prescribed within present guidelines, can aid modest weight loss in about one-third of patients."( Cahill, A; Lean, ME, 1999)
"Orlistat is a novel non-systemic treatment for obesity."( Hvizdos, KM; Markham, A, 1999)
"Surgical treatment of obesity (bariatric surgery) is the only effective long term solution for many patients."( Cannizzo, F; Kral, JG, 1998)
"Prevention and treatment of obesity are major clinical problems encountered in the management of Type 2 diabetes mellitus (DM); indeed, up to 90% of such patients are regarded as being overweight."( Donaldson, D; Tremble, JM, 1999)
"UDCA is not effective for the treatment of obesity-related liver abnormalities in children."( Aragione, N; Franzese, A; Iannucci, MP; Vajro, P; Valerio, G, 2000)
"Another potential target in the treatment of obesity is increasing energy expenditure via beta3 adrenoceptors or uncoupling proteins."( Mertens, IL; Van Gaal, LF, 2000)
"Drugs to treat obesity can be divided into three groups: those which reduce food intake, those which alter metabolism and those which increase thermogenesis."( Bray, GA, 1999)
"However, drug treatment of obesity resulted in unexpected devastating events in recent years."( Ballmer, PE; Imoberdorf, R, 2000)
"With regard to the treatment of obesity, a conscious decreased consumption of foods high in ED and an increase in consumption of low-ED food is necessary to decrease and subsequently maintain body weight, particularly in subjects with a sedentary lifestyle."( Westerterp-Plantenga, MS, 2001)
"The lack of efficiency of classical treatments for obesity has led to propose alternative strategies."( Del Barrio, AS; Fernández-Quintela, A; Portillo, MP; Simón, E, 2000)
"Leptin itself seems ineffective in treating most human obesity, but alternative means of activating appetite-regulatory pathways downstream of leptin are targets for future pharmacological approaches to aid weight loss."( Wilding, JP, 2001)
"Numerous options for treating obesity exist, and the clinician should be made aware of their strengths and limitations."( Moyad, MA, 2001)
"Before leptin can play a role in the treatment of obesity, more studies are needed to discover which is the adequate dose, which the best route and form of administration and how we can select the patients who will benefit from this particular therapy."( Frühbeck, G; Gomez-Ambrosi, J; Salvador, J, 2001)
"The implications for pharmacological treatment of human obesity are discussed."( Bloom, SR; Goldstone, AP; Swaab, DF; Unmehopa, UA, 2002)
"Sibutramine treatment in obesity results in significantly greater weight reduction compared with placebo, although weight loss with sibutramine may be accompanied by small but statistically significant mean increases in blood pressure (BP)."( Ernst, KR; Fujioka, K; Johnson, F; McMahon, FG; Rowe, E; Weinstein, SP, 2002)
"The use of TH in the treatment of obesity is hardly justified except in cases of elevated thyrotropin (TSH) with low/normal T(3) and T(4) and/or a low T(3) or T'(3)/T(4) or a high TSH/T(3) ratio."( Krotkiewski, M, 2002)
"Anorectic drugs are widely used for the treatment of obesity."( Michelakis, E, 2002)
"Preventing and treating obesity in bipolar disorder patients could decrease the morbidity and mortality related to physical illness, enhance psychological well-being, and possibly improve the course of bipolar illness."( Fagiolini, A; Frank, E; Houck, PR; Kupfer, DJ; Novick, DM, 2003)
"At present, the access to treat obesity is still in its early stage and the function of leptin identified in 1994 is also the focus of debate."( Huang, ZY; Sun, ZJ, 2001)
"Historically, the drugs used for the treatment of obesity generally targeted small molecule neurotransmitters."( Kane, JK; Konu, O; Li, MD, 2003)
"Orlistat treatment of obesity results in a poor long-term weight loss (< 5%) in about 30% of patients."( Erdmann, J; Margraf, J; Schusdziarra, V; Ullrich, A, 2003)
"Outpatient's Service for Prevention and Treatment of Obesity at the University Hospital of Messina, Italy."( Buemi, M; Corica, F; Corsonello, A; De Domenico, D; Ientile, R; Loddo, S; Malara, A; Perticone, F, 2003)
"The classic treatment of obesity is weight loss via lifestyle modification."( Lebovitz, HE, 2003)
"Currently approved pharmacologic treatments for obesity include sibutramine and orlistat, which have been associated with significantly greater weight loss than that seen with dieting alone."( Aronne, LJ; Thearle, M, 2003)
"To identify new drug targets for the treatment of obesity, we employed a degenerate reverse transcriptasepolymerase chain reaction technique to isolate novel members of the G-protein coupled receptor superfamily from mouse hypothalamus."( Foley, KP; Geddes, BJ; Gu, W; Stricker-Krongrad, A; Zhang, C, 2004)
"Modafinil may be well suited for the treatment of obesity, although further studies with repeated dosing in overweight populations are warranted."( Frederich, RC; Kelly, TH; Makris, AP; Rush, CR, 2004)
"Among methods of treatment of obesity the most known and safe is the low calories content diet."( Kawecka-Jaszcz, K; Rajzer, M; Wojciechowska, W, 2004)
"Novel approaches to treatment of obesity must aim at manipulating these brain structures."( Born, J; Fehm, HL; Peters, A, 2004)
"Since treatment for obesity on outpatient bases often fails, we evaluated whether camps may help to improve eating habits."( Campanaro, P; Chiarelli, F; D'Angelo, G; Di Ferdinando, C; Di Pietro, M; Pomilio, M; Verrotti, A, 2004)
"Without adequate prevention and treatment of obesity, government agencies have suggested that the direct and indirect costs associated with obesity may overwhelm the healthcare system."( Joyal, SV, 2004)
"LCD might play a role in the treatment of obesity and hepatic steatosis in rats, but it exerts no significant effect on both serum lipid disorders and hepatic inflammatory changes."( Fan, JG; Li, MS; Tia, LY; Wang, GL; Xu, ZJ; Zhong, L, 2005)
"The interest in the use of drugs in the treatment of obesity has grown in recent years, upon our knowledge of the biological basis of obesity having increased, and also because non-pharmacological treatments have not succeeded stopping the constant increase of obesity incidence in western countries."( Astorga Jiménez, R; Pereira Cunill, JL, 2005)
"Dietary treatment of obesity could be improved if predictive information about the individual's genetic response to diet was available."( Coltell, O; Corella, D; Godoy, D; Greenberg, AS; Ordovas, JM; Portolés, O; Qi, L; Sorlí, JV, 2005)
"These data suggest the use of EET for treatment against obesity and diabetes for both AAW and CW."( Basilio, JL; Berggren, JR; Cortright, RN; Dohm, GL; Hickner, RC; Houmard, JA; Hulver, MW; Sandhoff, KM, 2006)
"(1) The treatment of obesity is based on calorie reduction and moderate physical activity."( , 2006)
"To improve the effective prevention and treatment of obesity, it is important to focus on body weight (BW) development and its determinants during childhood."( Bouwman, F; Hornstra, G; Kester, AD; Mariman, EC; Posthumus, DL; Rump, P; Vogels, N; Westerterp-Plantenga, MS, 2006)
"JNKs are attractive targets for treatment of obesity and type-2 diabetes."( Galimi, F; Karin, M; Lee, MS; Naugler, W; Solinas, G, 2006)
"Although bupropion is not approved for treating obesity, three randomized clinical trials have shown some degree of efficacy for this drug in promoting weight loss in obese patients."( Gadde, KM; Xiong, GL, 2007)
"We investigated whether treatment of obesity and its associated metabolic abnormalities corrects salt sensitivity and restores impaired nitric oxide (NO) metabolism characteristic of salt sensitivity."( Alfieri, AB; Cubeddu, LX; Hoffmann, IS, 2007)
"Pharmacological treatment of obesity must be considered as a therapeutical tool that has to be used together with long-term lifestyle changes, contributing to the body weight reduction as well as to the improvement of the cardiometabolic risk related to obesity."( Gargallo, M; Isabel Millán, A; Moreno, B; Rubio, MA, 2007)
"Recently, newer approaches for the treatment of obesity have involved inhibition of dietary triglyceride absorption via inhibition of pancreatic lipase (PL) as this is the major source of excess calories."( Bhutani, KK; Birari, RB, 2007)
"A major problem in treating obesity is high rates of relapse to maladaptive food-taking habits during dieting."( Bossert, JM; Ghitza, UE; Golden, SA; Gray, SM; Nair, SG; Shaham, Y; Uejima, JL, 2007)
"Rimonabant is a novel drug for treatment of obesity."( Aronsen, L, 2008)
"Although effective treatment for obesity is still awaited, many developments have occurred to improve our understanding of neuroendocrine regulation of food intake and weight gain, especially regarding the role of gut hormones."( le Roux, CW; Vincent, RP, 2008)
"Patients treated for obesity with jejunoileal bypass (JIB) experienced a marked increased risk of hyperoxaluria, nephrolithiasis, and oxalate nephropathy developing."( Duffey, BG; Hinck, B; Ikramuddin, S; Kellogg, T; Kriedberg, C; Makhlouf, A; Monga, M; Pedro, RN; Slusarek, B; Stessman, M, 2008)
"Until better treatments for obesity are available, management remains focused on lifestyle changes, drug therapy, and treating the metabolic complications of obesity."( Sharma, AM, 2008)
"However, its potential to treat obesity, a major health concern affecting over 30% of the population, has not been fully explored."( Bina, HA; Chen, Y; Coskun, T; Dunbar, JD; Hu, CC; Kharitonenkov, A; Moller, DE; Schneider, MA, 2008)
"Nutritional strategies to treat obesity often influence neuroendocrine factors related to body weight control."( Abete, I; Crujeiras, AB; Goyenechea, E; Martinez, JA; Parra, D, 2008)
"Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity."( Bikman, BT; Bowden, RC; Chapman, W; Cortright, RN; Dohm, GL; Houmard, JA; Lee, J; Pender, JR; Pories, WJ; Reed, MA; Tanner, CJ; Tapscott, EB; Zheng, D, 2008)
"However, the potential of treating obesity is enormous, bearing in mind that a volitional weight loss of 10 kg is associated with important risk factor improvement: blood pressure -10 mmHg, total cholesterol -10%, LDL cholesterol -15%, triglycerides -30%, fasting glucose -50%, HDL cholesterol +8%."( Pagotto, U; Pasquali, R; Vanuzzo, D; Vicennati, V, 2008)
"After 30 days of the treatment, obesity was evidenced in HS rats from enhanced body weight, respiratory quotient, hypertriglyceridemia."( Assalin, HB; Ebaid, GX; Fernandes, AA; Mani, F; Novelli, EL; Rocha, K; Santos, PP; Seiva, FR; Souza, G, 2009)
"No interaction between the randomized treatment and obesity for efficacy and safety outcomes was observed across the range of BMI in this dataset."( Antman, EM; Aylward, PE; Becker, RC; Califf, RM; Col, JJ; Ducas, J; Ferguson, JJ; Gallo, R; Goodman, SG; Langer, A; Levine, GN; Mahaffey, KW; Spinler, SA; Tonev, ST; White, HD, 2010)
"Although pharmacological treatment of obesity is widely used in most countries, the number of available drugs is still very limited."( Coutinho, W, 2009)
"Thus, the treatment of obesity could be improved through the use of substances that interfere with Ang-II."( Begg, DP; Jois, M; Weisinger, RS, 2009)
"Orlistat is approved for the treatment of obesity and has been evaluated both in obesity and in the several obesity-related co-morbidities."( McClendon, KS; Riche, DM; Uwaifo, GI, 2009)
"The effects of medical and surgical treatments for obesity on peptide YY (PYY) levels, in patients with similar weight loss, remain unclear."( Acosta, AM; Boza, C; de la Cruz, R; Irribarra, V; Liberona, Y; Maiz, A; Valderas, JP; Yolito, M, 2010)
"Upon cessation of the weight loss treatment, several obesity-related pathologies (i."( Cassone, M; Ferla, R; Hatfield, MP; Kovalszky, I; Lovas, S; Olah, J; Otvos, L; Scolaro, L; Surmacz, E; Sztodola, A, 2010)
"Current options for medical treatment of obesity are limited by recent withdrawals of Rimonabant and Sibutramine, enhancing the need for further development of novel weight-loss drugs."( Barber, TM; Begbie, H; Levy, J, 2010)
"LAGB is effective in treatment of obesity patients with T2DM."( Dai, X; Huang, H; Jiang, ZT; Li, Y; Zheng, F; Zou, YP, 2010)
"Leukemia treatment leads to obesity."( Apak, H; Bolayirli, M; Canbolat, A; Celkan, T; Ercan, O; Karaman, S; Onal, H; Ozkan, A; Yildiz, I, 2010)
"Current pharmacological treatments for obesity and metabolic syndrome have various limitations."( Cheng, P; Di, W; Ding, G; Hu, M; Li, Y; Liu, J; Lv, S; Qi, H; Wang, L; Wu, L; Yu, J; Zha, J; Zhang, A; Zhang, X; Zhong, Y, 2011)
"The effects of medical and surgical treatments for obesity on glucose metabolism and glucagon-like peptide 1 (GLP-1) levels independent of weight loss remain unclear."( Boza, C; Escalona, M; Irribarra, V; Liberona, Y; Maiz, A; Matamala, A; Rubio, L; Valderas, JP, 2011)
"After 12 wk of treatment, obesity-associated factors, including body weight, organ weight, serum concentrations of glucose, triacylglycerol, insulin, and adipokines, and macrophage accumulation and lipid metabolism-associated factors in epididymal adipose tissue were measured."( Chan, MH; Chang, HP; Chen, YH; Chiu, YS; Wang, ML, 2011)
"Possible future treatment of obesity with CBR1 antagonist could involve cyclic treatment of specific peripheral compounds."( Bennetzen, MF, 2011)
"Through efforts to prevent, screen, and treat obesity in adults, clinicians and public health practitioners can collaborate to reduce the impact of obesity on U."( , 2011)
"These data suggest phentermine treatment for obesity does not result in increased SBP, DBP, or HR, and that weight loss assisted with phentermine treatment is associated with favorable shifts in categorical blood pressure and retardation of progression to hypertension in obese patients."( Greenway, FL; Gupta, AK; Hendricks, EJ; Westman, EC, 2011)
"Thus, CAP may be a viable treatment for obesity, insulin resistance and inflammation."( Begg, DP; Cameron-Smith, D; Hafandi, A; Jois, M; Manickam, E; Premaratna, SD; Rayment, DJ; Weisinger, RS, 2012)
"The lack of safe and effective treatments for obesity has increased interest in natural products that may serve as alternative therapies."( Alonso, M; Bermúdez-Silva, FJ; Crespillo, A; de Fonseca, FR; Fernández-Llebrez, P; Martínez, A; Pavón, FJ; Pérez-Valero, V; Rivera, P; Romero-Zerbo, Y; Serrano, A; Suárez, J; Vida, M, 2011)
"The surgical treatment of obesity ameliorates metabolic abnormalities in patients with type 2 diabetes."( Arasaki, CH; Carneiro, G; Geloneze, B; Silva, EA; Umeda, LM; Zanella, MT, 2011)
"Current therapeutic strategies for the treatment of obesity are unsatisfactory."( Chen, JD; Sallam, HS, 2011)
"Although pharmacological treatments for obesity represent only one option in managing obesity, they are a useful tool in an otherwise extremely limited armamentarium."( Billes, SK; Greenway, FL, 2011)
"Pharmaceutical strategies in the treatment of obesity include drugs that regulate food intake, thermo genesis, fat absorption, and fat metabolism."( Cardoso, MR; Ferreira, GK; Gomes, LM; Jeremias, IC; Martinello, OB; Morais, MO; Quevedo, J; Rezin, GT; Streck, EL; Valvassori, SS, 2011)
"Future development of drugs for the treatment of obesity will be dependent on whether they can survive review for safety and effectiveness."( Downey, M; Sharma, AM; Still, C, 2011)
"The need for treatment of obesity and obesity-related diseases, such as type 2 diabetes, has been intensified by the epidemic rise of obesity."( Alberts, P; Johansson, BG; McArthur, RA, 2005)
"Exenatide is a potential new candidate treatment for obesity, possibly in combination with other hormones that increase satiety (leptin) and slow gastric emptying (amylin)."( Folli, F; Guardado Mendoza, R, 2011)
"Current strategies to treat obesity are limited and there is a need to pioneer novel solutions."( Bloom, SR; De Silva, A; Zac-Varghese, S, 2011)
"In the meantime, treatment of obesity-hypertension has relied on antihypertensive drugs."( Haynes, WG; Kalil, GZ, 2012)
"Drugs found were primarily for treating obesity-related medical conditions such as depression, hypertension, and coronary heart disease."( Botch, SR; Chaturvedi, AK; Ricaurte, EM, 2012)
"While treating obesity in children, a major emphasis should be directed towards increasing regular physical activity and supported with dietary interventions."( Cengiz, T; Karacabey, K; Zorba, E, 2011)
"While overall treatment of obesity is unsuccessful, T treatment of hypogonadal men may be effective, also because it improves mood, energy, reduces fatigue and may motivate men to adhere to diet and exercise regimens designed to combat obesity."( Aversa, A; Gooren, LJ; Isidori, AM; Saad, F, 2012)
"Drug treatment of obesity offer a possible adjunct, but it may only have modest results, limited by side effects; furthermore, the weight lowering effects last only as long as the drug is being taken and, unfortunately, as soon as the administration is stopped, the weight is regained."( Bedros, JR; Medvegy, M; Pados, G; Simonyi, G, 2012)
"BPS may be beneficial for the treatment of obesity-associated glucose intolerance."( Hashimoto, T; Ichiki, T; Ikeda, J; Inoue, E; Kamiharaguchi, A; Matsuura, H; Sunagawa, K; Takeda, K, 2012)
"Within each treatment group, obesity was associated with higher rates of cesarean delivery, pregnancy-related hypertension, macrosomia, and hyperbilirubinemia (all p < 0."( Desch, C; Istwan, N; Joy, S; Rhea, D; Roman, A; Saltzman, D; Stanziano, G, 2012)
"Bariatric surgery is the most effective treatment of obesity."( Goldstone, AP; Hackenberg, T; Jackson, RN; Jackson, SN; le Roux, CW; Miras, AD; Olbers, T; Spector, AC, 2012)
"Developing interventions to prevent and treat obesity are medical and public health imperatives."( Asao, K; Herman, WH; Luo, W, 2012)
"The efficacy of metformin for the treatment of obesity has been evaluated in few clinical trials with inconclusive results."( Schehler, B; Schneider, HJ; Seifarth, C, 2013)
"Bariatric surgery for the treatment of obesity may affect biomarkers of oxidative stress."( Biscaro, F; Dadalt, C; de Freitas, MB; Fagundes, RL; Jordão Júnior, AA; Moreira, EA; Pedrosa, RC; Vannucchi, H; Wilhelm-Filho, D, 2013)
"Current therapeutic treatment for obesity is mostly focused on preventive measures involving dietary control and physical exercises in combination with anti-obesity medications."( Cho, H; Cho, YS; Choi, GD; Choi, K; Im, HY; Jang, H; Kim, CH; Kim, YJ; Ko, M; Kwon, OS; Lee, J; Pae, AN; Park, WK; Seo, YW; Tae, J; Yang, HY, 2013)
"The cornerstones of treatment for obesity, and even more so for simple overweight, are dietary measures and physical exercise."( , 2013)
"This has clinical implications for the treatment of obesity-related hypertension and kidney disease."( Dudka, J; Korolczuk, A, 2014)
"Surgical treatments for obesity, although highly effective, are unavailable or unsuitable for the majority of individuals with excess adiposity."( Padwal, RS; Rueda-Clausen, CF; Sharma, AM, 2013)
"Many drugs for the treatment of obesity, which mainly act through CNS as appetite suppressants, have failed during development or been removed from the market due to unacceptable adverse effects."( Bhanot, S; Chakravarty, K; Manchem, VP; McCaleb, ML; Monia, BP; Watts, LM; Yu, XX, 2013)
"Currently, the most effective treatment for obesity is bariatric surgery."( Abul, H; Al-Khaledi, G; Al-Sabah, S; Al-Saleh, M; Alasfar, F; Dinesh, R, 2014)
"Surgical treatment of obesity (bariatric surgery) is the most effective long-term treatment modality for those patients suffering from higher degrees of obesity."( Fried, M, 2013)
"While treating obesity, those conditions are also managed."( Baretić, M, 2013)
"Efforts to prevent and treat obesity in Malaysian children will need a substantial focus on the promotion of reductions in sedentary behaviour and increases in physical activity."( Hamzaid, H; Reilly, JJ; Talib, RA; Wafa, SW, 2014)
"In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1."( Baek, SH; Chung, HJ; D'Souza, R; Hong, ST; Jeon, Y; Kim, HJ; Kweon, SJ; Lee, HK, 2014)
"Bariatric surgery is the most effective treatment for obesity and also greatly improves glycaemic control, often within days after surgery, independently of weight loss."( Dirksen, C; Holst, JJ; Madsbad, S, 2014)
"Both treatment of obesity and prevention of obesity-related diseases are frequently not successful."( Blüher, M, 2014)
"The prevention and treatment of obesity in children is based on adequate nutrition and exercise plus antihyperglycaemic drugs."( Astiz, I; Astiz, S; Barbero, A; Garcia-Real, I; Gonzalez-Bulnes, A; Perez-Solana, ML, 2014)
"Medications for the treatment of obesity began to appear in the late 19th and early 20th century."( Bray, GA, 2014)
"Spa therapy has long been used for treating obesity and its comorbidities."( Adamczyk, P; Fioravanti, A; Giannitti, C; Pascarelli, NA; Ponikowska, I; Tołodziecki, M; Urso, R, 2015)
"Over the past decade, treatment for obesity has been limited because of an incomplete understanding of the pathophysiology of obesity, lack of recognition of it as a disease, and limited efficacy of treatment options."( Aronne, LJ, 2014)
"Behavioral modifications for the treatment of obesity, including caloric restriction, have notoriously low long-term success rates relative to bariatric weight-loss surgery."( Benoit, SC; Egan, AE; Grayson, BE; Hakala-Finch, AP; Herman, JP; Kekulawala, M; Laub, H; Ressler, IB; Seeley, RJ; Ulrich-Lai, YM; Woods, SC, 2014)
"Combination treatment, obesity and infusion reactions were found to be predictors of drug survival."( Lopez-Ferrer, A; Puig, L; Spertino, J; Vilarrasa, E, 2014)
"Drug treatments for obesity have proven efficacy from randomized trials, but their effectiveness in routine clinical practice is unknown."( Batterham, RL; Bhaskaran, K; Douglas, IJ; Smeeth, L, 2015)
"As new treatments for obesity are approved, their effectiveness should be measured in routine clinical practice, as effectiveness may be considerably less than seen in randomized trials."( Batterham, RL; Bhaskaran, K; Douglas, IJ; Smeeth, L, 2015)
"Both treatments induced obesity but only Ob-MSG showed altered behavioral parameters, which is related to increased concentration of corticosterone and hypothalamic ERK1 and 2 activation."( Andreazzi, AE; de Caires Júnior, LC; de Freitas Mathias, PC; Gonçalves, CF; González Garcia, RM; Guimarães, ED; Macedo de Almeida, M; Mourao-Júnior, CA; Musso, CM; Paes, ST; Pettersen, KG; Torrezan, R, 2017)
"Exercise is a first-line means to treat obesity and its complications."( Picklo, MJ; Thyfault, JP, 2015)
"To improve treatment of obesity, a contributing factor to multiple systemic and metabolic diseases, a better understanding of metabolic state and environmental stress at the cellular level is essential."( Janorkar, AV; Tang, Y; Turner, PA; Weiss, SJ, 2015)
"A new target for the treatment of obesity may be the incretin system, which consists of hormones that seem to contribute to weight loss."( Cardoso, LC; de Bona Schraiber, R; de Mello, AH; Prá, M; Rezin, GT, 2015)
"An important target for the treatment of obesity includes the development of inhibitors of nutrient digestion and absorption."( Buchholz, T; Melzig, MF, 2015)
"Thus, HE helps in the prevention and treatment of obesity-related diseases by enhancing the lipolytic capacity."( Ishibashi, Y; Ishida, H; Izawa, T; Kizaki, T; Ogasawara, J; Ohira, Y; Ohno, H; Sakurai, T; Shirato, K, 2015)
"The present drugs used for treating obesity do not give satisfactory results, and on prolonged usage result in severe side effects."( Bondili, JS; Chalasani, LM; Raj, KK; Talluri, VR; Veeramachaneni, GK, 2015)
"Leptin is not able to treat typical obesity; however, it is effective for reversing leptin deficiency-induced obesity and is possibly useful in lipodystrophy."( Farr, OM; Gavrieli, A; Mantzoros, CS, 2015)
"Current drug treatments for obesity produce small and usually unsustainable decreases in body weight with the risk of major adverse effects."( Brown, L; Panchal, SK; Poudyal, H, 2015)
"One potential target for the treatment of obesity is via manipulation of the gut-brain axis, a complex bidirectional communication system that is crucial in maintaining energy homeostasis."( Bauer, PV; Duca, FA; Hamr, SC, 2016)
"Various drugs have been developed to treat obesity, but these have undesirable secondary effects, and an efficient but non-toxic anti-obesity drug from natural sources is desired."( Huang, W; Su, M; Zhu, B, 2016)
"The high cost of treatment of obesity-related asthma, and the burden it causes for the patients and their families call for urgent intervention."( Mota-Pinto, A; Muc, M; Padez, C, 2016)
"Liraglutide was approved for the treatment of obesity and other GLP-1RAs are likely to be suitable for this indication."( Chan, P; Hu, M; Liu, ZM; Tomlinson, B; Zhang, Y, 2016)
"Pharmacotherapeutic strategies to treat obesity are urgently needed."( Dwoskin, LP; Narayanaswami, V, 2017)
"We identify a target for treating obesity and type 2 diabetes, the consumption of calories by an increase in the metabolic rate of resting skeletal muscle."( Canton, M; Cooke, R; Naber, N; Nogara, L; Pate, E; Reggiani, C, 2016)
"ECS is a pharmacological target for the treatment of obesity, inflammation, cardiovascular and neuronal damage, and pain."( German, N; Larumbe, E; Samson, J; Schlabritz-Loutsevitch, N; Ventolini, G, 2016)
"Nevertheless, for the treatment of obesity and its consequences, more studies and therapeutic strategies in addition to adenosine are necessary."( Chiarello, DI; Gutierrez, J; Leiva, A; Pardo, F; Salsoso, R; Sobrevia, L; Toledo, F; Villalobos-Labra, R, 2017)
"We review the use of MBS as a treatment for obesity and obesity-related conditions and, based on recent evidence, propose that health care systems make the appropriate changes to increase accessibility for eligible patients."( Corcelles, R; Flores, L; Jiménez, A; Lacy, AM; Vidal, J, 2017)
"Since these strategies fail to treat hypothalamic obesity, we have assessed the possible mechanisms by which duodenal-jejunal bypass (DJB) surgery regulates hepatic lipid metabolism and the morphophysiology of pancreatic islets, in hypothalamic obese (HyO) rats."( Araújo, AC; Balbo, SL; Bonfleur, ML; Boschero, AC; Cantelli, KR; Lubaczeuski, C; Ribeiro, RA; Soares, GM, 2017)
"Metformin appears to be an effective treatment of obesity including those with the PWP in FXS."( Dy, ABC; Eldeeb, M; Hagerman, R; Salcedo-Arellano, MJ; Tartaglia, N; Tassone, F, 2018)
"The surgical and pharmacological treatments of obesity are discussed, and evidence is presented for the selective use of DA-class drugs in obesity treatment."( Cameron, JD; Chaput, JP; Goldfield, GS; Sjödin, AM, 2017)
"Current treatments toward obesity including diet, physical exercise, pharmacological therapy, as well as surgeries are always associated with low effectiveness or undesired systematical side effects."( Gu, Z; Liu, Q; Qiang, L; Wang, J; Yu, J; Yu, S; Zhang, Y, 2017)
"Background Prevention and treatment of obesity is a way to reduce cardiovascular disease, diabetes and depression."( Ghahremanloo, A; Hajipour, R; Hemmati, M; Mohaqiq, Z; Moossavi, M, 2017)
"Bariatric surgery is an effective treatment for obesity."( Polanco, G; Salehi, M; Smith, EP; Yaqub, A, 2018)
"These may help tailor a treatment for the obesity with BED phenotype."( Astbury, N; Aviram-Friedman, R; Contento, I; Geliebter, A; Ochner, CN, 2018)
"Antipsychotic-induced weight gain and untreated obesity showed some similarities, confirming that levels of some hormones, such as leptin and ghrelin, are related to body mass index rather than to antipsychotic exposure."( Bravaccio, C; Cabaro, S; Carotenuto, M; Catone, G; Coppola, G; D'Esposito, V; Formisano, P; Iuliano, R; Miraglia Del Giudice, E; Pisano, S, 2018)
"We hypothesised that pravastatin treatment in obesity improves lipid profiles, insulin-resistance and myocardial resistance to ischaemia/reperfusion (I/R) injury."( Beck, B; Donner, D; du Toit, EF; Headrick, JP; Oi, M; Peart, J; Wendt, L, 2018)
"Patients at different stages of treatment for obesity were recruited to this single-centre cross-sectional study."( Boshier, PR; Fehervari, M; Hanna, GB; Markar, SR; Purkayastha, S; Smith, D; Spanel, P, 2018)
"We studied the effect of apelin treatment on obesity-induced type 2 diabetes mellitus (T2DM) and possible interaction between apelin/APJ system and renin-angiotensin system (RAS)."( Ahmed, MM; Kamar, SS; Mahmoud, MM; Rashed, L; Sabry, MM; Shoukry, HS, 2019)
"The current pharmacological treatment of obesity remains limited and ineffective due to drugs' undesirable side effects."( Madiehe, AM; Meyer, M; Onani, MO; Sibuyi, NRS; Thovhogi, N, 2018)
"However, drugs for the prevention and treatment of obesity and NAFLD remain unavailable."( Ding, Y; Lei, F; Liao, L; Song, Y; Sun, P; Wang, W; Xie, W; Zhang, X; Zhang, Y; Zhong, J, 2018)
"Standard treatment of obesity with lifestyle interventions including diet, exercise, and behavioral modification has been shown to improve NASH as well as reduce cardiovascular dysfunction."( Kumar, RB; Mathews, SE; Shukla, AP, 2018)
"To assess if intranasal leptin can treat obesity hypoventilation and upper airway obstruction during sleep in mice with DIO."( Ahima, RS; Anokye-Danso, F; Berger, S; Bevans-Fonti, S; Enquist, LW; Fleury-Curado, T; Jun, JC; Mendelowitz, D; Pho, H; Polotsky, VY; Schwartz, AR; Shin, MK; Younas, H, 2019)
"Group (1) was considered as normal untreated rats."( Abo-Elmatty, DM; Ahmed, SA; El-Sayed, NM; Ibrahim, AK; Mehanna, ET, 2018)
"IL-17 treatment( the obesity rate[( 23."( Du, Z; Li, H; Lu, X; Luo, S; Shen, T; Wu, M; Zhang, X; Zhu, Q, 2018)
"The multi-disciplinary treatment of obesity now includes the use of pharmacotherapy."( Andrew, CA; Aronne, LJ; Saunders, KH; Shukla, AP, 2019)
"Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss."( Biggs, EK; Davy, K; Gribble, FM; Hardwick, RH; Hornigold, DC; Kay, RG; Larraufie, P; Leiter, A; Li, J; McGavigan, AK; Melvin, A; Ravn, P; Reimann, F; Roberts, GP; Yeo, GSH, 2019)
"Aim - optimization of the treatment of obesity and chronic heart failure (CHF) patients by identifying key factors for the progression of cardiac decompensation and the principles of using metoprolol succinate, taking into account pharmacogenetic aspects in the complex treatment of this comorbidity."( Gasanov, I; Rudyk, Y, 2019)
"However, its potential to treat obesity and the subsequent metabolic dysfunctions have been difficult to assess owing to its short half-life in vivo."( Bjerregaard, A; Christoffersen, C; Clemmensen, C; DiMarchi, RD; Feuchtinger, A; Finan, B; Grunddal, KV; Hartmann, B; He, Z; Holst, B; Leinninger, GM; Ratner, C; Skov, LJ; Tschöp, MH; Williams, KW; Zhang, F, 2019)
"In search for new immune based treatments of obesity associated insulin resistance, we screened for tissue relevant anti-inflammatory properties in 20 plant-based extracts."( Chan, YT; Chen, HY; Clemente-Casares, X; Coburn, B; Khan, S; Lei, H; Leu, YL; Lin, YH; Luck, H; Schneeberger, PHH; Tsai, S; Winer, DA; Winer, S; Yang, SH, 2019)
"Ginseng has therapeutic potential for treating obesity and the associated gut microbiota dysbiosis."( Auyeung, KK; Chen, HB; Li, SL; Mao, Q; Xu, J; Ye, R; Yip, KM; Zhao, ZZ; Zhou, SS, 2020)
"These results provide a new potential treatment for obesity in the future."( Chen, CC; Lee, TY; Leu, YL; Wang, SH, 2019)
"Developing effective treatments for obesity and related metabolic disease remains a challenge."( Lam, TKT; Yue, JTY, 2019)
"Asian herbs have the potential to treat obesity, however, pharmacological effects should be well documented at the molecular level first."( Buhlmann, E; Horváth, C; Houriet, J; Kiehlmann, E; Marcourt, L; Radtke, J; Schröder, S; Wolfender, JL; Wolfrum, C, 2019)
"Despite a wide array of options for treatment of obesity, rates of sustained weight loss continue to be low, leading patients to seek alternative treatment options."( Gershuni, VM; Hurt, RT; Kuchkuntla, AR; Mundi, MS; Nanda, S; Rajjo, T; Shah, M; Velapati, S, 2019)
"However, obesity and treatments for obesity such as bariatric surgery can influence absorption, excretion, pharmacokinetics, and pharmacodynamics of various anticoagulants."( Carrier, M; Wang, TF, 2020)
"Development of non-invasive treatment to treat obesity and type-2 diabetes is still unmet needs."( Chang, HM; Hsu, WH; Hu, CC; Jebaranjitham, N; Lai, JY; Lee, YL; Prasannan, A; Tsai, HC; Wang, JS; Yang, JM, 2020)
"Pimozide treatment reversed obesity-induced hyperglycemia in mice, which was phenocopied in mice with muscle-specific Oxct1/SCOT deficiency."( Aguer, C; Al Batran, R; Almutairi, M; Byrne, NJ; Campbell, JE; Capozzi, ME; Chahade, JJ; Crawford, PA; Desta, Z; Dyck, JRB; Eaton, F; Garneau, L; Gopal, K; Greenwell, AA; Kim, R; Masson, G; Masters, AR; Mulvihill, EE; Niu, J; Saleme, B; Sutendra, G; Tabatabaei-Dakhili, SA; Ussher, JR; Velázquez-Martínez, CA, 2020)
"We characterized the phenotype of NCS- treated obesity and investigated the alterations of hepatic function and underlying mechanisms."( Bhattacharjee, J; Bouret, S; Jang, A; Kohli, R; Merritt, R; Michail, S; Park, S; Salazar-Gonzalez, RM; Warren, M; Xi, D, 2020)
"Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone."( Bastard, JP; Capeau, J; Charchour, R; Collet, C; Cuerq, C; Dufour-Rainfray, D; Fellahi, S; Genoux, A; Lacorte, JM; Morineau, G; Vatier, C; Vigouroux, C, 2020)
"Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is associated with increased levels of the incretin hormone glucagon-like peptide-1 (GLP-1) and changes in levels of circulating bile acids."( Aliakbarian, H; Chaudhari, SN; Devlin, AS; Harris, DA; Henke, MT; Luo, JN; Sheu, EG; Subramaniam, R; Tavakkoli, A; Vernon, AH, 2021)
"However, the therapeutic options to treat obesity are limited."( Diéguez, C; Fernández-Real, JM; López, M; Nogueiras, R; Rahmouni, K; Seoane-Collazo, P, 2021)
"Recent advances in the treatment of obesity and related co-morbidities have focused on the therapeutic potential of anorexigenic gut hormones, such as glucagon-like peptide 1 (GLP-1), which acts both peripherally and centrally to reduce energy intake."( Brown, RM; Goldstone, AP; Guerrero-Hreins, E; Sumithran, P, 2021)
"Furthermore, treatment of obesity is affected by the widespread misuse of drugs and food supplements."( Bernardini, R; Burgaletto, C; Cantarella, G; Cortinovis, M; Di Mauro, R; Frara, S; Giustina, A; Munafò, A; Perico, N; Remuzzi, G, 2021)
"The prevention and treatment of obesity have become one of the most significant public health challenges worldwide in the 21st century, and how to effectively curb the occurrence of obesity has become a major global concern."( Chen, S; Gao, T; Han, Y; Liu, M; Ma, D; Zhang, X, 2021)
"The prevention and treatment of obesity have become a significant public health challenge worldwide."( Fu, J; Wang, Y; Zhou, Y, 2021)
"Most strategies to treat obesity-related disorders have involved prevention of diet-induced weight gain in lean mice."( Cortez, BN; Desevin, K; Emili, A; Farmer, SR; Hekman, R; Lin, JZ; Rabhi, N, 2021)
"Bariatric surgery is the best treatment for obesity and its complications."( Cerón-Solano, G; Morin, JP; Roldán-Roldán, G; Romero Lozano, JG; Zepeda, RC, 2021)
"In the treatment of obesity, nutritional and behavioral modifications are difficult to implement and maintain."( Demitri, C; Madaghiele, M; Panteca, E; Rescigno, M; Sannino, A; Silvestri, A; Surano, I; Vitale, M; Zohar, Y, 2021)
"A variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity."( Barrios, A; Dirakvand, G; Pervin, S; Singh, R, 2021)
"This effect has been used to treat overweight/obesity, especially with comorbidities associated with T2DM."( Mandarim-de-Lacerda, CA; Spezani, R, 2022)
"For this reason, other targets for the treatment of obesity are mentioned."( Coveñas, R; Marcos, P, 2022)
"Novel strategies are being used to treat obesity, including leptin and testosterone therapy."( Arora, H; Farber, N; Khodamoradi, K; Khosravizadeh, Z; Mallepalli, S; Seetharam, D, 2022)
"On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation."( Ghasemzadeh Rahbardar, M; Hosseinzadeh, H; Mehri, S; Najafi, N, 2022)
"Interest in GIPR agonism for the treatment of obesity and diabetes was recently propelled by the clinical success of unimolecular dual-agonists targeting the receptors for GIP and GLP-1, with reported significantly improved body weight and glucose control in patients with obesity and type II diabetes."( Akindehin, SE; DiMarchi, RD; Haqq, AM; Müller, TD; Orsso, CE; Tan, Q; Waldner, RC, 2022)
"Current treatments for obesity do not reliably reduce body weight over time."( Doucette, WT; Khokhar, JY; Ruiz-Jaquez, M; Smedley, EB; Smith, KS, 2022)
"roots (OSR) for treatment of obesity and metabolic disorders requires а scientific rationale."( Ferrante, C; Georgiev, MI; Marchev, AS; Mladenova, SG; Orlando, G; Savova, MS; Wabitsch, M, 2022)
"Given the potential of boron in the treatment of obesity, the aim of this study is to investigate the anti-adipogenic activity of the newly synthesised boron glycine monoester compound (BGM) using 3T3-L1 adipocytes by analysing lipid accumulation, CTRP3 and PPARy gene expression, oxidative stress and apoptotic effects."( Koldemir Gündüz, M, 2022)
"To explore the best treatment of obesity in middle and old age."( Dai, W; Peng, Q, 2022)
"Liraglutide has been approved for the treatment of obesity in the past few years."( Gong, F; Guo, X; Lyu, X; Pan, H; Wang, L; Wang, X; Xu, H; Yan, K; Yang, H; Zhu, H, 2022)
"SEFA-1024 may serve as a potential treatment for obesity-related diabetes and NAFLD."( Anez-Bustillos, L; Cho, BS; Dao, DT; Feigh, M; Fell, GL; Fraser, DA; Gura, KM; Ko, VH; Pan, A; Puder, M; Secor, JD; Yu, LJ, 2022)
"To explore the effect of JAT in the treatment of obesity and the underlying molecular mechanisms."( An, L; Deng, J; He, H; Li, X; Yang, M; Ye, X, 2022)
"The impact of preventing and treating obesity on cognitive outcomes merits study."( Abi Saleh, R; Benjamin, EJ; Fornage, M; Griswold, ME; Hammond, PI; Lirette, ST; Mosley, TH; Turner, ST; Windham, BG, 2022)
"In contrast, treating obesity with GLP-1RA decreases cardiovascular risk and the possible mechanisms of cardioprotection achieved by this class of drugs are discussed."( Bronzeri, F; de Carvalho Cara, LG; de Cassia Rocha, A; Eliaschewitz, FG; Fogo, SL; Franco, DR; Gieremek, HW; Pedrosa, MR; Vidal, CM, 2022)
"Acupuncture has been widely used to treat obesity."( Ding, W; Gong, Y; He, Y; Jin, Y; Liang, X; Xia, X; Xie, Y; Yang, Y; Zhan, M, 2022)
"Potential targets for the treatment of obesity were identified based on the DisGeNET database."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"The network pharmacology of escin in treating obesity may involve 10 hub targets (STAT3, MTOR, NR3C1, IKBKB, PTGS2, MMP9, PRKCA, PRKCD, AR, CYP3A4), 10 GO enriched terms and 13 related pathways."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"Potential targets for the treatment of obesity were identified based on the DisGeNET database."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"The network pharmacology of escin in treating obesity may involve 10 hub targets (STAT3, MTOR, NR3C1, IKBKB, PTGS2, MMP9, PRKCA, PRKCD, AR, CYP3A4), 10 GO enriched terms and 13 related pathways."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"Potential targets for the treatment of obesity were identified based on the DisGeNET database."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"The network pharmacology of escin in treating obesity may involve 10 hub targets (STAT3, MTOR, NR3C1, IKBKB, PTGS2, MMP9, PRKCA, PRKCD, AR, CYP3A4), 10 GO enriched terms and 13 related pathways."( Cui, XY; Guan, YX; Jin, Y; Wang, D; Zhang, QH, 2022)
"We evaluated a novel treatment for obesity-related renal, an ATP-citrate lyase (ACL) inhibitor, to attenuate ectopic lipid accumulation (ELA) in the kidney and the ensuing inflammation."( He, J; Li, A; Li, Y; Li, Z; Sun, J; Wu, X; Zhan, Z; Zhang, H; Zhang, W, 2022)
"Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like peptide-1 (GLP-1R; e."( Brierley, DI; Chianese, R; Cristiano, C; Dowsett, GKC; Gribble, FM; Heisler, LK; Jiang, W; Lam, BYH; Leeson-Payne, A; Lyons, D; Martinez de Morentin, PB; Reimann, F; Trapp, S; Wagner, S; Yeo, GSH, 2023)
"Finally, studies for the treatment of obesity (SURMOUNT program) and metabolic-associated fatty liver disease (MAFLD) are also ongoing."( Scheen, AJ, 2023)
"Chronic CORT treatment induced obesity, longer small intestines, hepatic steatosis and elevated levels of serum insulin and leptin in mice; CORT-treated mice showed increased cell proliferation and decreased apoptosis of small intestines; RNA-seq results indicate that differentially expressed genes (DEGs) were enriched in several cell growth/death-associated signaling pathways."( Cao, L; Li, S; Li, T; Li, Y; Lu, J; Wang, G; Xu, T; Zhang, M, 2022)
"This article reviews GLP-1 RAs in the treatment of obesity and previews the imminent future of nutrient-stimulated hormone-based anti-obesity therapeutics."( Jastreboff, AM; Kushner, RF, 2023)
"Long-term treatment of obesity with lifestyle changes alone is unsustainable for most individuals because of several factors including adherence and metabolic adaptation."( Andre, C; Aronne, LJ; D'Angelo, D; Sahagun, AD; Shukla, AP; Tchang, BG; Weintraub, MA, 2023)
"Therefore, prevention and treatment of obesity and its related comorbidities are critical."( Bagherniya, M; Butler, AE; Emami, SA; Lavian, S; Mardaneh, P; Sahebkar, A, 2023)
"Metabolic surgery is the most effective treatment for obesity and may improve obesity-related pain syndromes."( Bonham, AJ; Carlin, AM; Deng, C; Dennis, A; Varban, OA; Yang, P, 2023)
"Weight loss is important both to treat obesity and to prevent the development of complications."( Armentaro, G; Arturi, F; Cassano, V; Giofrè, F; Pelle, MC; Sciacqua, A; Zaffina, I, 2023)
"After P101 treatment, obesity-related indicators were downregulated, and the hepatic injury and gut barrier disruption in mice were alleviated effectively."( Hu, L; Xu, H; You, T; Zhao, Y, 2023)
"The results showed that CR and E2 treatment reduced obesity-induced-cardiac hypertrophy in ovariectomized groups (20% and 24% respectively)."( Bejeshk, MA; Dabiri, S; Darvishzadeh Mahani, F; Hajializadeh, Z; Khaksari, M; Raji-Amirhasani, A, 2023)
"It has been used for the treatment of obesity, gestational diabetes, and polycystic ovary syndrome."( Gonzalez-Lopez, C; Wojeck, BS, 2023)
"Thus, adequate treatment for obesity is necessary, including lifestyle changes (diet adequation and physical activity) and pharmacotherapy."( Abel, JDS; da Silva, LE; da Silva, MR; de Aguiar da Costa, M; de Oliveira, MP; Ludvig Gonçalves, C; Rezin, GT; Tartari, G, 2023)
"However, the evidence of treating obesity for primary prevention of major cardiovascular events is still scarce and controversial."( Cercato, C; de Melo, ME; Mancini, MC; Santos, RD; Stumpf, MAM, 2023)
"Promising approaches to the treatment of obesity include increasing energy expenditure and slowing down fibrogenesis of adipose tissue."( Babenko, AY; Khromova, NV; Kononova, YA; Matveev, GA; Shlyakhto, EV; Vasilyeva, EY; Zasypkin, GG, 2023)
"Thus, PLB likely had the potential to treat obesity-related asthma."( Liang, D; Liu, L; Zhang, L, 2023)

Research

Studies (54,963)

TimeframeStudies, This Condition (%)All Conditions %
pre-19909325 (16.97)23.3326
1990's5353 (9.74)12.5806
2000's12143 (22.09)18.1394
2010's20086 (36.54)28.8240
2020's8056 (14.66)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetylcarnitine0medium121
dinitrochlorobenzene0low50
alpha-hydroxyglutarate0low10
2-oxo-3-methylvalerate0low20
alpha-ketoisovalerate0low30
2,3-diphosphoglycerate0medium11
2,5-dichlorophenol0low20
2-keto-4-methylvalerate0medium122
protocatechuic acid0medium41
3-hydroxyisobutyric acid0medium21
3-hydroxykynurenine0low10
acetoacetic acid0medium161
phosphoserine0low130
3-phenylpropionic acid0low10
n-carbamoyl-beta-alanine0low10
gamma-aminobutyric acid0medium532
4-hydroxybenzyl alcohol0low10
4-hydroxybenzaldehyde0low20
4-hydroxyphenylacetic acid0low20
4-hydroxybenzoic acid0low10
aminolevulinic acid0low10
5-aminovaleric acid0low20
5-hydroxytryptophan0medium143
ethylene glycol0medium11
acetic acid0medium375
acetaldehyde0low60
acetone0medium331
adenine0medium244
agmatine0low20
curdlan0low10
ammonium hydroxide0medium379
quinacrine0low30
beta-alanine0low70
benzene0low40
benzoic acid0low20
betaine0medium387
bromide0low70
1-butanol0low70
butyric acid0medium365
cadaverine0low10
carbamates0medium185
carbamyl phosphate0medium11
carbon monoxide0low300
formic acid0low20
carnitine0medium16230
catechol0low20
methane0medium196
chlordecone0low10
choline0medium716
citric acid, anhydrous0medium368
chlorine0medium443
hydrochloric acid0medium31
coumarin0low30
cuminaldehyde0low10
salicylic acid0low110
phloroglucinol0low50
gallic acid0medium271
octanoic acid0low80
hydrogen sulfide0medium361
dihydrolipoic acid0low10
trimethylenediamine0low10
3-hydroxybutyric acid0medium12320
n(1)-methylnicotinamide0medium51
guaiacol0low30
hippuric acid0medium41
2-aminoadipic acid0low10
4-aminoimidazole0low10
methylmalonic acid0medium31
n(g),n(g')-dimethyl-l-arginine0medium419
malic acid0low20
3,4-dihydroxyphenylacetic acid0low140
aminocaproic acid0low20
creatine0medium606
cytosine0low110
lactic acid0medium21323
diethyl phosphate0low10
o,o-diethyl phosphorothionate0low10
dihydroxyacetone0medium41
dimethylamine0low20
dimethyl sulfoxide0medium72
ethanolamine0low50
formaldehyde0medium51
gamma-butyrobetaine0low40
hexachlorocyclohexane0low40
glycine0medium985
glyceraldehyde0low20
glycerol0medium47363
alpha-glycerophosphoric acid0low80
glycolic acid0low10
glyoxylic acid0low10
hydrogen cyanide0low40
hydrogen carbonate0medium525
dalteparin0medium6613
histamine0medium666
hydrogen0medium288
hydroquinone0low30
hydroxylamine0low10
imidazole0low40
indole0low30
indoleacetic acid0low20
iodine0medium934
itaconic acid0low30
dihydroxyphenylalanine0medium182
kynurenine0low310
2,3,4,5-tetrahydroxypentanal0low30
thioctic acid0medium7315
malonic acid0low20
racemethionine0low20
pyruvaldehyde0medium264
methanol0medium222
phytic acid0low50
inositol0medium6615
melatonin0medium1718
croton oil0low20
naphthalene0low20
nickel0medium81
niacinamide0medium656
nitrates0medium8313
nitric acid0low20
nitroxyl0low10
nitrites0medium628
nitrous oxide0medium232
orotic acid0low60
oxalic acid0medium121
oxamic acid0low10
4-aminobenzoic acid0low50
4-nitrophenol0low10
hexadecanal0low10
palmitic acid0medium22813
pentachlorophenol0low10
phenanthrene0low10
phenol0medium51
phenylpyruvic acid0low10
phenylacetic acid0medium21
phosphoenolpyruvate0low50
phosphorylcholine0low70
phosphorylethanolamine0low10
phthalic acid0low440
picolinic acid0medium209
porphobilinogen0low10
diphosphoric acid0low10
pqq cofactor0low30
propylene glycol0medium43
1-propanol0low50
propionic acid0medium164
pteridines0low30
purine0low70
putrescine0medium51
pyrazinamide0low20
pyrazole0low50
pyridine0low10
pyridoxal0low10
pyridoxal phosphate0medium51
pyridoxamine0medium71
pyridoxamine phosphate0low10
pyridoxine0medium222
pyrogallol0medium41
pyruvic acid0medium696
quinolinic acid0low10
thiosulfates0low90
sarcosine0low20
selenic acid0low20
selenious acid0low20
sulfites0medium41
spermidine0low150
spermine0low130
succinic acid0medium221
sulfur dioxide0medium63
taurine0medium9910
thiamine0medium494
thymine0low30
toluene0low30
trimethyloxamine0medium3512
trimethylamine0medium53
uracil0medium103
uric acid0medium86147
urea0medium15615
vanillin0low50
xanthine0low30
sk&f 812970low10
8-hydroxy-2-(di-n-propylamino)tetralin0low60
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid0low20
4-iodo-2,5-dimethoxyphenylisopropylamine0low20
ibotenic acid0low10
gallopamil0low20
normetanephrine0low30
sk&f-383930low80
vanilmandelic acid0medium181
menthol0medium61
1,2-dimethylhydrazine0low30
1,3-dipropyl-8-cyclopentylxanthine0low30
pk 111950low10
1-(3-chlorophenyl)piperazine0medium61
1-anilino-8-naphthalenesulfonate0medium66065
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine0low10
14,15-epoxy-5,8,11-eicosatrienoic acid0low20
n-(3-(aminomethyl)benzyl)acetamidine0low10
17-octadecynoic acid0low10
2,2'-dipyridyl0low10
2,4-dichlorophenoxyacetic acid0low10
2,4-dinitrophenol0low80
gw 24330low10
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine0low20
mercaptoethanol0low20
2-methyl-5-ht0low10
3,4-methylenedioxyamphetamine0low20
n-methyl-3,4-methylenedioxyamphetamine0low30
amitrole0low10
phaclofen0low10
aminopropionitrile0low30
3-hydroxybenzylhydrazine0low10
3-methylcholanthrene0low20
3-nitropropionic acid0low10
4-aminopyridine0low30
homovanillic acid0medium111
4-nonylphenol0low10
phenytoin0low300
5-hydroxydecanoate0low20
hydroxyindoleacetic acid0medium403
7,8-dihydroxyflavone0low10
7-chlorokynurenic acid0low10
7-nitroindazole0low10
8-(4-sulfophenyl)theophylline0low10
8-phenyltheophylline0low20
oxyquinoline0medium11
2,2'-azobis(2-amidinopropane)0low10
acebutolol0low10
acemetacin0medium11
acetazolamide0medium466
acetohexamide0low50
adrenic acid0low10
albuterol0medium264
alendronate0medium21
alosetron0low20
alpha-cyano-4-hydroxycinnamate0low10
alprazolam0medium42
alprenolol0low10
am 2510low230
am 5800low10
amantadine0medium51
ambroxol0low10
diatrizoic acid0low10
amifostine anhydrous0low20
aminoglutethimide0medium41
pimagedine0low90
p-aminohippuric acid0low40
theophylline0medium828
amiodarone0low110
dan 21630low20
amitriptyline0low140
amlexanox0medium71
amlodipine0medium4221
amobarbital0medium81
amsacrine0low10
anastrozole0medium134
anthralin0low10
antipyrine0medium141
acetovanillone0low170
apraclonidine0low60
aprindine0low10
arecoline0low20
aristolochic acid i0low30
arotinolol0low10
aspirin0medium16120
astemizole0low30
atenolol0medium2917
atrazine0low20
azathioprine0medium91
2,2-bis(4-glycidyloxyphenyl)propane0low10
bay-k-86440low20
bendroflumethiazide0low20
benfluorex0medium206
benserazide0low20
benzbromarone0medium41
benzo(a)pyrene0low40
benzothiazide0medium33
benzyl isothiocyanate0low30
butylbenzyl phthalate0low20
berberine0medium671
diminazene0low10
beta-naphthoflavone0low10
betaxolol0medium11
bethanechol0low10
bicalutamide0medium32
bisacodyl0low10
bisindolylmaleimide i0low30
bisoprolol0medium41
bromazepam0low10
bromhexine0low20
buformin0low80
bunazosin0medium52
bupivacaine0medium172
buspirone0low10
busulfan0medium91
secbutabarbital0low10
cacodylic acid0low20
verapamil0medium236
camostat0low20
candesartan cilexetil0medium21
candesartan0medium298
carbamazepine0medium183
carmustine0medium21
carteolol0low10
carvedilol0medium51
cefuroxime0low20
celiprolol0medium41
cgp 121770low140
chloral hydrate0low10
chlorambucil0low10
chlordiazepoxide0medium51
chloroquine0low120
chlorothiazide0medium151
chlorpheniramine0low10
chlorpromazine0medium264
chlorpropamide0medium418
chlorpyrifos0low130
chlorthalidone0medium157
chlorzoxazone0medium121
ciglitazone0low110
cilostamide0low30
cilostazol0medium41
cimaterol0low10
cimetidine0medium196
ciprofibrate0medium51
ciprofloxacin0low70
citalopram0medium189
clenbuterol0low90
clobenpropit0low20
clofazimine0low10
clofibrate0medium463
clofibric acid0medium181
clomipramine0medium53
clonazepam0low20
clonidine0medium587
4-cresol0medium31
cyclobenzaprine0low10
cyclofenil0low10
cyclopenthiazide0low30
cyproheptadine0low60
cystamine0low10
danthron0low10
dantrolene0low30
dapi0low30
dapsone0medium31
decanoic acid0low30
deferoxamine0low40
desipramine0medium51
nordazepam0low10
nonivamide0low20
amphetamine0medium19910
eflornithine0medium11
diazepam0medium276
dibucaine0low10
dibutyl phthalate0low50
diclofenac0medium62
dichlorodiphenyl dichloroethylene0low280
ddt0low180
dichlorophen0low10
diethylcarbamazine0low10
pentetic acid0low40
3,3'-diindolylmethane0low10
dimaprit0low10
diphenhydramine0low30
diphenyleneiodonium0low10
dipyridamole0low40
disopyramide0low10
distigmine0low10
valproic acid0medium718
racemetirosine0low60
1-phenyl-2-palmitoylamino-3-morpholino-1-propanol0low10
domperidone0low20
donepezil0low30
adtn0low10
doxapram0low30
doxazosin0medium32
doxepin0low20
droperidol0low40
e 40310low10
ebselen0low50
edrophonium0low10
embelin0low50
emodin0low130
enflurane0medium102
enoxacin0low10
epinastine0low10
erythrosine0medium72
ethacrynic acid0medium71
ether0low100
profenamine0low10
ethosuximide0low10
ethoxyquin0low20
ethoxyresorufin0low10
eicosapentaenoic acid ethyl ester0medium92
etilefrine0low10
famotidine0low10
carbonyl cyanide p-trifluoromethoxyphenylhydrazone0low30
felbamate0low10
felodipine0medium54
fenbendazole0low10
flavoxate0low10
flecainide0low10
fleroxacin0low10
fluconazole0low60
flucytosine0low10
fluphenazine0low20
flumazenil0low240
fluorouracil0medium277
flurbiprofen0low50
flutamide0medium125
fomepizole0low10
foscarnet0low10
furosemide0medium364
gabapentin0medium51
gabexate0low20
gemfibrozil0medium177
gentamicin0low220
2,5-dihydroxybenzoic acid0low10
gliclazide0medium217
glimepiride0medium148
glipizide0medium1810
glutethimide0low10
glyburide0medium8818
glyphosate0medium75
guaifenesin0low50
guanethidine0medium101
guanfacine0low30
guanidine0low10
1-(5-isoquinolinesulfonyl)-2-methylpiperazine0low40
fasudil0low20
haloperidol0medium307
halothane0medium433
hexachlorophene0low10
hexamethonium0low40
hexobarbital0low20
tele-methylhistamine0low30
hexamethylene bisacetamide0low10
ethidium0low30
hydralazine0medium141
hydrochlorothiazide0medium5826
hydroflumethiazide0low10
hydroxychloroquine0medium232
hydroxyurea0low10
hydroxyzine0low40
ibuprofen0medium52
phenelzine0low30
ifosfamide0low20
imetit0low20
imipramine0medium62
indapamide0medium114
indirubin-3'-monoxime0low30
indomethacin0medium324
iodixanol0medium21
iohexol0medium102
iomeprol0medium11
iopanoic acid0medium21
iopromide0medium21
ioversol0low20
indolepropionic acid0low30
ipriflavone0low10
iproniazid0low20
avapro0medium309
1-methyl-3-isobutylxanthine0low160
isocarboxazid0medium11
isoflurane0medium309
isoniazid0medium81
2-propanol0low20
isradipine0medium11
staurosporine aglycone0low10
ketamine0medium185
ketanserin0low40
ketoconazole0low50
ketoprofen0low10
ketorolac0low20
ketotifen0medium41
khellin0low20
kynurenic acid0low100
labetalol0medium53
lansoprazole0medium62
beta-lapachone0low20
lauric acid0medium31
leflunomide0low20
letrozole0medium294
nordefrin0low10
lg 1002680low70
lithium hydroxide0low10
loperamide0medium64
loratadine0low20
lorazepam0low50
losartan0medium449
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one0low210
malathion0low10
manidipine0medium43
mebendazole0low10
mecamylamine0low30
meclofenamic acid0low20
mefruside0low10
meperidine0low130
mepivacaine0low30
meprobamate0low40
mesalamine0low10
metaproterenol0medium21
methadone0medium153
methiothepin0low20
methoxsalen0low10
methoxychlor0low10
methoxyflurane0low140
methyclothiazide0medium32
methyl parathion0low10
methyl salicylate0medium43
methylphenidate0medium316
metoclopramide0medium133
metolazone0low20
metronidazole0medium194
metyrapone0medium472
mexiletine0low20
mianserin0medium52
miconazole0low10
midodrine0low10
milrinone0low10
mirtazapine0medium41
mitotane0low40
mitoxantrone0low20
modafinil0medium52
moxisylyte0low10
entinostat0low20
muscimol0low40
deet0low10
1-(3-trifluoromethylphenyl)piperazine0low20
ethylmaleimide0low10
fg 71420low10
deoxyepinephrine0low10
apnea0medium598
nafronyl0medium11
activins0low130
nefazodone0low10
neostigmine0medium91
nevirapine0low20
nialamide0low20
nicardipine0medium21
niclosamide0low30
nifedipine0medium247
niflumic acid0low10
nimesulide0low40
nimodipine0low10
nisoxetine0low20
nitrazepam0low10
nitrendipine0medium94
nitroglycerin0medium355
nomifensine0low10
norfenefrine0medium21
norfloxacin0low20
nortriptyline0medium32
ns 16190low10
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide0low60
o(6)-benzylguanine0medium11
octopamine0medium71
ofloxacin0medium21
omeprazole0medium114
ondansetron0medium41
oxonic acid0low10
oxazepam0low20
oxidopamine0low20
oxybenzone0low10
oxybutynin0medium113
oxyphenbutazone0low30
aminosalicylic acid0low10
fenclonine0low30
4-iodoclonidine0low10
palmidrol0low150
pamidronate0low10
pantoprazole0medium72
papaverine0low50
1,7-dimethylxanthine0low20
pargyline0low30
pd 980590low90
pentobarbital0medium142
pentoxifylline0medium101
perazine0low10
perhexiline0low10
perphenazine0low40
phenacetin0low10
phenindione0low20
pheniramine0low10
phenmetrazine0medium10913
phenobarbital0medium311
phenolphthalein0low80
phenolsulfonphthalein0medium31
phenoxybenzamine0low20
4-phenylbutyric acid0low170
phenyl biguanide0low10
phenylbutazone0low50
phloretin0low50
moxonidine0medium225
pifithrin0low10
pinacidil0low20
pindolol0medium41
piperazine0low30
piracetam0low20
pirenperone0low10
pirenzepine0medium298
piribedil0medium11
potassium chloride0medium291
4-aminobenzoic acid0low10
practolol0low10
praziquantel0low20
prazosin0low230
prilocaine0medium11
primidone0low10
probucol0medium42
procainamide0low10
procaine0low50
procarbazine0low10
procaterol0low10
prochlorperazine0medium42
proglumetacin0low10
proglumide0medium41
promethazine0low20
propantheline0low10
propranolol0medium11310
protoporphyrin ix0medium21
protriptyline0medium31
rabeprazole0medium43
opc 127590low10
resorcinol0low10
risperidone0medium6412
ritanserin0medium51
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone0low10
rofecoxib0low40
rolipram0low50
roxarsone0low10
saccharin0medium512
sarpogrelate0low20
sb 2390630low10
scriptaid0low10
sebacic acid0low10
carbamylhydrazine0low50
sennoside a&b0medium31
sulfadiazine0medium11
sk&f 914880low10
sodium fluoride0low30
sodium iodide0low10
iodoacetic acid0low20
sotalol0medium52
spiperone0low10
fenofibrate0low10
ponalrestat0low30
stearic acid0medium141
succinylcholine0low190
sulfamethoxazole0low10
sulfanilamide0low50
sulfinpyrazone0low20
sulfisoxazole0medium21
sulfobromophthalein0low230
sulforaphane0low190
sulpiride0low140
suramin0low20
tazarotene0low20
1,4-bis(2-(3,5-dichloropyridyloxy))benzene0low40
tegafur0low20
temozolomide0medium11
terazosin0low20
terbutaline0low140
tetraethylammonium0low10
krypton0low20
thalidomide0medium101
theobromine0medium113
2,4-thiazolidinedione0medium533
thioridazine0low20
thiotepa0low30
thiothixene0low10
ticlopidine0medium214
nikethamide0low30
tofisopam0low10
tolazamide0medium81
tolazoline0low10
tolbutamide0medium18310
tolmetin0low10
tranexamic acid0medium51
trazodone0medium11
tremorine0low10
triamterene0low40
triazolam0medium31
trichlormethiazide0low20
triclosan0medium132
trientine0low10
trifluoperazine0medium31
trigonelline0low30
trimipramine0low10
troglitazone0medium9618
tropicamide0low10
tyramine0low60
tyrphostin a90low10
urapidil0medium11
urethane0low10
usnic acid0low30
viloxazine0low10
w 70low10
pirinixic acid0low170
xanthurenic acid0low20
xylazine0low10
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole0low10
zinc chloride0medium11
hydrocortisone acetate0low10
mitomycin0medium21
corticosterone0medium3231
prednisolone0medium462
estriol0medium283
lysergic acid diethylamide0low40
reserpine0medium291
cephaloridine0medium43
sorbitol0medium313
alloxan0low150
thymidine0low170
benzimidazole0low40
3,3',5-triiodothyroacetic acid0low130
hydroxyproline0medium263
thyroxine0medium38827
dibenzylchlorethamine0low10
methacetin0medium51
carbachol0low230
norethindrone acetate0medium53
spironolactone0medium6615
prednisolone acetate0low10
aldosterone0medium25614
pentolinium tartrate0low10
penicillamine0low60
lynestrenol0medium41
tetrahydrocortisol0medium82
prednisone0medium998
tetrahydrocortisone0low60
paramethasone0low10
fluprednisolone0low20
methylprednisolone acetate0low20
oxandrolone0medium32
androsterone0low280
etiocholanolone0low170
dehydroepiandrosterone0medium25820
2-acetylaminofluorene0low10
penicillin g0low40
metaraminol0low10
pilocarpine0low40
dimethylphenylpiperazinium iodide0low20
pentylenetetrazole0low10
triiodothyronine0medium46443
diethylnitrosamine0low120
biguanides0medium998
carbon tetrachloride0low80
alanine0medium1506
serine0medium661
desoxycorticosterone acetate0low20
4-nitroquinoline-1-oxide0low20
chloramphenicol0low20
aspartic acid0medium251
glutamine0medium857
lysine0medium804
allyl isothiocyanate0low20
cyanides0low10
sucrose0medium45138
ethinyl estradiol0medium7134
chlordan0low20
testosterone propionate0low30
tubocurarine0low10
9,10-dimethyl-1,2-benzanthracene0low140
apomorphine0low30
aminopyrine0low40
methyltestosterone0low90
adenosine diphosphate0medium401
2,3,4,6-tetrachlorophenol0low20
uridine0low50
uridine monophosphate0low10
uridine diphosphate0low20
kanamycin a0low30
bromodeoxyuridine0medium91
galactose0medium447
carbostyril0medium449
levodopa0medium404
edetic acid0medium112
tributyrin0low20
p-dimethylaminoazobenzene0low10
phenylethyl alcohol0medium161
phlorhizin0low260
acepromazine0low20
methoxamine0low50
adenosine monophosphate0medium461
methicillin0low20
methylene blue0medium81
bretylium tosylate0low10
zoxazolamine0low10
leucine0medium18518
methacholine chloride0medium595
2-aminoisobutyric acid0low20
dimethylnitrosamine0low10
androstenedione0medium18222
cytidine diphosphate0low10
lactose0medium173
methionine0medium933
1,2-dipalmitoylphosphatidylcholine0low10
phenylalanine0medium534
desoxycorticosterone0low120
colchicine0medium264
gallamine triethiodide0low10
cytidine0low10
n-hexanal0low10
oxacillin0low10
cycloheximide0low130
ficusin0low10
egtazic acid0low10
barbituric acid0low10
chloroform0low40
dimethyl sulfone0medium21
ethamoxytriphetol0low10
dimethylformamide0low10
norethindrone0medium249
norethynodrel0medium61
cycloserine0low10
17-alpha-hydroxyprogesterone0medium529
chlorisondamine0low40
ampicillin0medium111
mannitol0medium172
cytarabine0medium172
trifluridine0medium11
ornithine0low90
asparagine0medium91
histidine0medium315
medroxyprogesterone acetate0medium3610
valine0medium6612
threonine0medium371
mestranol0medium143
methaqualone0medium11
dichlorodiphenyldichloroethane0low50
methandrostenolone0medium51
chlorquinaldol0medium11
cordycepin0low30
isoleucine0medium391
arginine0medium41846
ethylene0medium63
methylamine0low30
boranes0medium41
propane0low10
vinyl chloride0medium51
methylene chloride0low20
carbon disulfide0low10
ethylene oxide0low10
bromodichloromethane0low20
2-propylamine0low10
tribromoethanol0low10
tert-butylhydroperoxide0low10
pivalic acid0low10
trichloroacetic acid0low30
trifluoroacetic acid0low20
perflutren0low10
triamcinolone acetonide0low20
phencyclidine0low80
tromethamine0low30
quinic acid0low50
triparanol0low20
linalool0low20
isoprene0low10
methylethyl ketone0low10
trichloroethylene0low10
acrylamide0low80
chloroacetamide0low10
dichloroacetic acid0low60
pempidine0low10
dimethisterone0low20
pantothenic acid0medium101
tetrabromobisphenol a0low10
bisphenol a0low1590
bis(4-hydroxyphenyl)sulfone0low190
dehydrocholic acid0low10
taurocholic acid0low120
rhodamine b0low20
pyridoxic acid0low30
methylprednisolone0medium203
rotenone0low20
dicyclohexyl phthalate0low20
9,10-anthraquinone0low10
diisobutyl phthalate0low10
phthalimide0low10
brompheniramine0medium11
1-hydroxy-2-naphthoic acid0low10
fluorene0low20
carbazole0low10
penicillin v0low40
isosorbide dinitrate0low20
penicillanic acid0medium71
xylitol0medium123
n-vinyl-2-pyrrolidinone0medium31
thiophene-3-carboxylic acid0low10
picryl chloride0low10
picric acid0low10
thymol0low60
xanthone0low20
pseudoephedrine0low10
benzohydrol0low10
quinoxalines0medium173
2-naphthylamine0low10
diphenyl0low10
3-hydroxy-2-naphthoic acid0low10
xanthenes0low40
cdaa0low10
synephrine0medium81
propylparaben0low90
benzylparaben0low10
benzothiazole0low10
alpha-chlorohydrin0low10
methyl acrylate0medium11
4-butyrolactone0medium251
lactobionic acid0low10
sulfosalicylic acid0low10
phosphoribosyl pyrophosphate0low20
furaldehyde0medium21
pyrrolidonecarboxylic acid0low140
3-hydroxybenzoic acid0medium11
trehalose0medium121
carvone0low10
methylparaben0low20
benzylamine0low60
benzonitrile0low10
nicotinyl alcohol0low20
quinuclidines0low30
cyclamic acid0low90
triclocarban0medium21
pyridostigmine bromide0medium226
normorphine hydrochloride0medium11
boric acid0low30
nonoxynol0low30
betazole0low10
caprolactam0medium63
citronellal0low10
4-phenylenediamine0low10
2,5-dioxopiperazine0medium11
epichlorohydrin0medium32
butane0low10
acrolein0low100
allylamine0low20
allyl alcohol0low10
2-methylpentane0low10
1,3-butylene glycol0low20
vinyl acetate0low10
cyclohexanol0medium191
pentane0low10
pyrroles0medium6822
thiophenes0medium697
succinamide0low10
isopropyl myristate0medium33
pentanal0low10
cyclohexane0low10
piperidine0low10
adiponitrile0low10
undecanoic acid0medium11
behenic acid0low20
ergotamine0low20
estradiol dipropionate0low10
phenformin0medium8919
triphenyl phosphate0low20
tris(chloroethyl)phosphate0low10
diethylhexyl phthalate0low320
hexachlorobenzene0low100
framycetin0medium151
dimethoxyphenylethylamine0low10
dibenzoylmethane0low10
ethyl-p-hydroxybenzoate0low10
2,4-dichlorophenol0low10
cyclopentanone0low10
3-tert-butyl-4-hydroxyanisole0low10
vanillic acid0low30
pyrazolanthrone0low40
dimethyl phthalate0low10
diatrizoate meglumine0low60
meglumine0medium41
monobutyl phthalate0low30
iodohippuric acid0low10
uridine diphosphate glucose0low60
1-naphthylamine0medium52
2-naphthol0low10
dextrothyroxine0medium71
shikimic acid0medium11
citronellol0low10
ethyl acetate0low60
2-hydroxypyridine0low10
hexanoic acid0low20
iminodiacetic acid0low10
n-heptane0low20
monomethylarsonic acid0low10
pregnenolone0low50
yohimbine0medium275
3-o-methylglucose0medium301
pentoxyl0medium11
ditiocarb0low10
potassium cyanide0low10
methohexital0medium21
o,o,s-trimethyl phosphorothioate0low10
dydrogesterone0medium21
catechin0medium18843
thiamine pyrophosphate0medium111
homoarginine0low40
diazooxonorleucine0low20
perylene0low10
cinnoline0low20
quinazolines0medium212
indazoles0low120
benzoxazoles0medium173
adamantane0medium458
cyclopentane0medium101
isoxazoles0medium358
oxazoles0medium323
thiazoles0medium28037
1,2,4-triazole0low10
pyridazine0low20
pyrimidine0low10
pyrazines0medium6221
ethynodiol diacetate0low60
nitroblue tetrazolium0low10
calcium gluconate0low10
diiodotyrosine0low10
hydrazine0low140
thiocyanate0low30
chlormadinone acetate0low40
3-phenylsalicylic acid0low10
ethamivan0low10
perfluorooctane0low10
evans blue0low20
monocrotaline0low20
testosterone enanthate0medium41
opipramol0low10
aminophylline0medium254
azacitidine0low70
triflusal0medium11
6-aminonicotinamide0low20
perfluorooctanoic acid0medium151
perfluorodecanoic acid0medium31
carbutamide0low100
perflexane0low30
nandrolone decanoate0medium22
aminoimidazole carboxamide0low300
methysergide0low30
methyl-4-tyramine0low10
citrulline0medium3010
betamethasone0medium93
prenylamine0low10
perflubron0low10
cyproterone acetate0medium2012
lithocholic acid0low40
nandrolone0medium94
2-aminopurine0low10
cyanogen0low10
hydantoins0low80
chlorphentermine0medium335
fluorobenzenes0medium201
homocystine0medium11
pipradrol0low30
glycyrrhetinic acid0low20
chenodeoxycholic acid0medium505
glycocholic acid0low20
liriodenine0low10
nuciferine0low70
fusarium0medium11
rhein0medium71
indirubin0low10
plumbagin0low30
aloe emodin0low10
chrysophanic acid0low20
imperatorin0low10
dihydroberberine0low10
emetine0low10
ninhydrin0low20
bicuculline0low70
flavanone0low20
kainic acid0low40
thymoquinone0low70
phenylpropanolamine0medium3612
indoline0low10
isomaltose0medium43
carvacrol0low20
olivetol0low10
4-hydroxyphenylethanol0low10
isovaleric acid0low20
alpha-aminopyridine0medium204
thiazolidines0low120
hexadecanedioic acid0low10
mustard gas0low10
margaric acid0low20
hexacosanoic acid0low30
oleanolic acid0medium321
dihydroergotamine0medium41
abietic acid0low10
hematoxylin0low20
podophyllotoxin0medium21
hesperidin0medium277
psilocybin0low10
medroxyprogesterone0medium152
androstenediol0low40
dihydrotestosterone0medium558
luminol0medium11
physcione0low10
flavone0low10
gluconic acid0low10
copper gluconate0low40
uridine diphosphate n-acetylglucosamine0low30
syringic acid0low30
thiamine monophosphate0low10
chlormethiazole0low10
methoxyhydroxyphenylglycol0medium82
carinamide0low10
methamphetamine0medium174
tricaprylin0low10
muscone0medium33
malondialdehyde0medium20833
myristic acid0low90
poldine methylsulfate0low10
poldine0low10
trinitrobenzenesulfonic acid0low50
eosine yellowish-(ys)0low30
gentian violet0low10
lithium carbonate0medium125
linamarin0low10
tripalmitin0low10
glycerylphosphorylcholine0medium21
2-hydroxybutyric acid0low10
docusate0low30
3-hydroxyflavone0medium274
allyl sulfide0low10
megestrol acetate0medium31
2,2-dimethylbutyric acid0low10
glycopyrrolate0low20
alpha-naphthoflavone0low40
dansyl chloride0low10
2-pyrrolidone0low10
acetylcysteine0medium321
ethyl pyruvate0low20
4,4'-bisphenol f0low90
4-hydroxypyridine0low10
c.i. 425100low20
clopenthixol0low10
phendimetrazine0low80
clopamide0medium92
glycochenodeoxycholic acid0low30
erythromycin0medium122
isocaproic acid0low10
dehydroepiandrosterone sulfate0medium19223
mannoheptulose0low100
methylnitrosourea0low30
2-chloroethyl ethyl sulfide0low10
diphenyliodonium0low10
ethylnitrosourea0low30
levonorgestrel0medium5014
calcium citrate0medium33
calcium lactate0medium11
adamantanecarboxylic acid0low10
naphthyl acetate0low10
ethyl gallate0low10
boldenone0low10
diphenoxylate0medium11
hexafluoroisopropanol0low10
1-methylpyridinium0low10
2-aminobenzimidazole0low10
deoxycytidine0medium137
deoxyuridine0low10
ethylestrenol0low20
testolactone0medium21
pentadecanoic acid0low20
ethambutol0medium61
nicotinamide mononucleotide0medium102
decabromobiphenyl ether0low10
3,4-dihydroxyacetophenone0low10
dehydroepiandrosterone acetate0low10
carmine0medium11
durapatite0low10
zinc oxide0medium71
monolaurin0low10
arsenic trioxide0low20
glycyrrhizic acid0low80
d-alpha tocopherol0medium20830
tocopherols0medium51
mesterolone0low10
pregnenolone carbonitrile0low10
1,2-epoxyhexane0medium33
selenomethionine0low50
methyl tert-butyl ether0low10
azaperone0low10
diphenyldiselenide0low10
digoxigenin0low20
[2-(2,6-dimethylanilino)-2-oxoethyl]-diethyl-(phenylmethyl)ammonium0low10
norfenfluramine0medium113
tetrachloroisophthalonitrile0medium21
s,n,n'-tripropylthiocarbamate0medium60572
2-tert-butylhydroquinone0low10
dronabinol0medium201
amiloride0low70
buthiazide0low10
diallyl trisulfide0low50
pimozide0low20
benperidol0medium41
flumethasone0low30
diallyl disulfide0low10
aminorex0low70
phenethyl isothiocyanate0low30
fluorescein0low20
methylprednisolone hemisuccinate0medium21
mirex0low10
alpha-methyldopamine0low10
flupenthixol0low20
fucose0low50
7,12-dihydroxymethylbenz(a)anthracene0low10
acadesine0low10
methyl methanethiosulfonate0low10
uridine diphosphate galactose0low10
stavudine0low20
dicloxacillin0low10
fluorescein-5-isothiocyanate0low20
sabinene0medium727
mannose0medium141
dithiothreitol0medium51
megestrol0medium51
azo rubin s0low10
tranylcypromine0low50
3-phenoxybenzoic acid0low30
nafenopin0low10
streptomycin0low40
carbonates0medium71
dideoxyadenosine0low10
valnoctamide0low10
cladribine0low10
monomethyl phthalate0low10
mono-(2-ethylhexyl)phthalate0low50
fructosamine0medium5716
tabersonine0low40
metanephrine0low40
trimetazidine0medium71
buthionine sulfoximine0low50
norleucine0low10
floxacillin0low10
raspberry ketone0low100
vidarabine0low30
o,o-diethyl o-3,5,6-trichloro-2-pyridyl phosphate0low10
iodinated glycerol0medium161
limonene0low40
4-pentynoic acid0low10
diazoline0low10
octocrylene0low20
n-methylaspartate0low40
3,5,6-trichloro-2-pyridinol0low10
bipiperidyl mustard0low50
trimethaphan0medium31
hepes0low10
iridium0medium21
lutetium0medium11
manganese0medium261
mercury0medium231
molybdenum0low60
neon0low10
palladium0medium21
platinum0low40
rhodium0low10
silver0medium105
tantalum0low10
technetium0medium133
thulium0medium33
titanium0medium175
tungsten0low20
cadmium0medium476
cerium0low30
chromium0medium6314
erbium0medium11
europium0medium21
gadolinium0low80
gold0medium1264
hafnium0low10
helium0low20
uranium0medium43
vanadium0low80
ytterbium0medium11
yttrium0medium11
zirconium0low10
cupric chloride0medium11
magnesium sulfate0medium73
acetylglucosamine0low260
galactosamine0low20
sodium nitrate0low70
hypochlorous acid0low20
camptothecin0medium61
ferric chloride0low30
ferrous sulfate0low10
bromine0medium101
barium sulfate0low130
potassium nitrate0low10
sodium sulfate0low10
sodium sulfite0low10
magnesium phosphate (2:3)0medium11
calcium phosphate, dibasic, anhydrous0low10
calcium phosphate, monobasic, anhydrous0low10
tricalcium phosphate0medium81
chromates0low20
copper sulfate0medium11
tungstate0low30
silver nitrate0low10
sodium thiosulfate0low70
calcium sulfate0low10
deuterium0medium853
fluorine0medium2410
chlorine0low50
deuterium oxide0medium373
molybdate ion0low10
ethinyl estradiol-norgestrel combination0medium105
galactose0medium215
poloxalene0low20
vasotocin0low10
ozone0medium414
ferric sulfate0low10
aluminum sulfate0low20
radon0low20
ferric pyrophosphate0low10
sodium selenite0low10
cadmium chloride0low10
4-chloro-7-nitrobenzofurazan0low20
barium chloride0low10
chlormerodrin0low10
trolamine salicylate0medium2773
stanozolol0medium21
rhamnose0low30
clodronic acid0low90
ammonium chloride0low60
ethionine0low10
titanium dioxide0low30
sodium tungstate(vi)0medium41
diacerein0medium42
technetium 99m0medium11
tiletamine hydrochloride0low60
selegiline0low10
phytanic acid0low20
levamisole0medium51
estetrol0low10
thiamphenicol0low10
pizotyline0low10
cephalexin0medium33
cromolyn sodium0low50
stearoylethanolamide0low20
tetradecanoylphorbol acetate0low190
sodium bisulfide0low10
fluorides0medium272
danazol0medium32
deslanoside0low20
metergoline0low50
lisuride0low80
cresyl violet0low10
chromium0medium31
1-deoxynojirimycin0medium297
calcium dobesilate0medium11
iodine0low70
daunorubicin0low120
leptophos0low10
fludarabine phosphate0low10
phosphotyrosine0low220
carbimazole0low20
zingerone0low30
phenyl acetate0medium14613
cetylpyridinium chloride anhydrous0medium26821
pyrrolidine0low20
triamcinolone0low90
tetrachloroethylene0low20
fludrocortisone0low50
pregnanolone0medium51
pyrene0low20
4-methoxyamphetamine0low210
du-212200low10
mono-benzyl phthalate0low10
8-bromo cyclic adenosine monophosphate0low40
transferrin0medium645
normeperidine0low10
androstane-3,17-diol0medium141
alkenes0low60
calcium oxalate0medium301
glutamic acid0low980
glucaric acid0low30
adenylyl imidodiphosphate0low10
azoxymethane0low330
azides0low40
adenosine diphosphate ribose0low60
halofenate0medium21
tramadol0medium41
almitrine0medium21
vanadyl sulfate0medium21
oxovanadium iv0low10
tetrahydrocannabivarin 90low10
enterobactin0low10
oxcarbazepine0medium11
s-adenosylmethionine0medium6510
zidovudine0low20
acetylgalactosamine0low10
5,7-dihydroxytryptamine0low20
3,4,3',4'-tetrachlorobiphenyl0low40
tobramycin0low70
paclitaxel0medium2811
etoposide0low60
substance p0medium251
acetosulfame0medium91
dobutamine0low290
tertatolol0low10
2,4,5,2',4',5'-hexachlorobiphenyl0low90
2,2',3',4,4',5-hexachlorobiphenyl0low20
ribavirin0medium206
amikacin0low10
phorbol 12,13-dibutyrate0low20
ciclazindol0medium22
2,3,4,2',3',4'-hexachlorobiphenyl0low10
methyldopa0medium142
bezafibrate0medium231
diltiazem0low80
vinclozolin0low10
vecuronium bromide0medium51
ng-nitroarginine methyl ester0medium582
deoxynivalenol0low20
permethrin0low10
pinazepam0medium11
chlorodiphenyl (54% chlorine)0low30
decamethrin0low10
pirfenidone0low10
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid0low20
desogestrel0medium143
meglitinide0low40
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide0low10
phosphopantothenic acid0low10
sufentanil0medium51
acarbose0low10
torsemide0low10
epirubicin0medium92
methyl(acetoxymethyl)nitrosamine0low10
desflurane0medium94
enkephalin, methionine0low100
idarubicin0low40
2,4,5,2',4',5'-hexabromobiphenyl0low10
dihydroalprenolol0low30
propiconazole0low40
nitrosobis(2-oxopropyl)amine0low10
piperacillin0medium81
cefotiam0low10
paroxetine0medium72
captopril0medium275
oltipraz0low10
atracurium0low60
arsenobetaine0medium11
nicorandil0low10
verofylline0low10
colforsin0medium484
iso-sulfan blue0low10
buserelin0medium71
alfentanil0low10
fomesafen0medium391
fenoxycarb0low30
miglustat0low20
cefotetan0medium32
lovastatin0medium151
2-amino-3-methylimidazo(4,5-f)quinoline0low10
ethyl 2-(5-(4-chlorophenyl)pentyl)oxiran-2-carboxylate0low20
simvastatin0medium5511
idazoxan0medium31
quinpirole0low40
3-hydroxymethyl-n-methylpiperidyl (4-chlorophenoxy)acetate0low40
pravastatin0medium224
atomoxetine hydrochloride0medium62
quinapril0medium82
raloxifene hydrochloride0medium94
mifepristone0medium355
itraconazole0low10
detomidine0low10
ractopamine0medium11
cilazapril, anhydrous0medium42
fosphenytoin0low20
ranolazine0low50
fura-20low40
finasteride0medium82
imiquimod0low60
esmolol0medium42
n-(8-aminohexyl)-5-iodonaphthalene-1-sulfonamide0low10
sertindole0medium21
loxiglumide0medium41
aromasil0medium43
englitazone0low20
zileuton0low10
clopidogrel0medium275
cidofovir anhydrous0low20
risotilide0low10
topotecan0low10
gemcitabine0medium95
aripiprazole0medium338
remifentanil0medium176
atorvastatin0medium6721
lamivudine0medium41
duloxetine hydrochloride0medium41
irinotecan0medium41
valsartan0medium3113
ziprasidone0medium162
3-iodobenzylguanidine0low20
darglitazone0medium41
emtricitabine0low40
relcovaptan0low10
capecitabine0medium42
adenosine0medium733
safranal0low20
ferric citrate0low30
sudan black b0low10
3-n-butylphthalide0low10
gadolinium chloride0low10
vanadates0medium231
fenproporex0medium72
dimethylhydrazines0low10
carfentanil0low20
tantalum oxide0low10
acridine orange0low10
isothiocyanic acid0low10
potassium phosphate0medium11
caloreen0medium112
2-amino-9h-pyrido(2,3-b)indole0low10
colestipol0low10
venlafaxine hydrochloride0medium61
trazodone hydrochloride0medium5521
cimetidine sulfoxide0low10
ciprofloxacin-7-ethylenediamine0low10
3,4,5,3',4'-pentachlorobiphenyl0low20
efavirenz0medium101
nelfinavir0low10
glucose, (beta-d)-isomer0medium14526
simvastatin acid0low10
chloroquine diphosphate0low10
fenofibric acid0low50
2',7'-dichlorofluorescein0low10
ursolic acid0medium161
meglumine antimoniate0low10
3-aminoisobutyric acid0low50
1,5-anhydroglucitol0medium94
thiazolyl blue0low10
3-methylhistidine0medium152
betulinic acid0low40
arctigenin0low20
baicalin0medium133
plerixafor0low30
amprenavir0low10
allicin0low60
5-methylcytosine0low40
epigallocatechin gallate0medium9826
n-acetylaspartic acid0low60
cholesteryl sulfate0low10
gallocatechol0medium21
6-sulfatoxymelatonin0medium51
aica ribonucleotide0low280
salvin0low60
testosterone undecanoate0medium209
2',5'-dideoxyadenosine0low10
nile red0low30
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose0low10
fluorophosphate0low10
pyrrolidine dithiocarbamate0low40
glutathione disulfide0medium153
secoisolariciresinol0low10
iopamidol0medium32
7-hydroxydehydroepiandrosterone0low10
cephalosporin c0medium142
cedrol0low10
tomatidine0low10
lathosterol0medium84
rutecarpine0low20
tretoquinol0medium11
trecadrine0low50
mci-1960medium53
lercanidipine0medium22
goralatide0low10
pidotimod0low10
repaglinide0medium31
telmisartan0medium5711
methacycline0medium203
bisphenol b0low10
trenbolone acetate0low10
xenon radioisotopes0low140
2-methoxyestradiol0low30
naphthalimides0low20
2-(n-cyclohexylamino)ethanesulfonic acid0low10
5,5'-methylenedisalicylic acid0low10
triazoles0medium9617
1h-tetrazole0low20
1,2,4-triazine0low10
perfluorododecanoic acid0low10
5-fluorosalicylic acid0low10
guanidinopropionic acid0low10
perfluorohexanesulfonic acid0medium61
perfluorobutane sulfonate0low10
perfluoro-n-nonanoic acid0low10
deuteroporphyrin-ix0low10
2,4,6-trihydroxyacetophenone0low20
tangeretin0low30
2,4,6-trihydroxybenzaldehyde0low10
isocoumarins0low10
phenylacetylglycine0medium21
delphinidin0low10
sesamol0low70
silver0low10
1-octacosanol0low10
methyl 2-tetradecylglycidate0low10
fluorodeoxyglucose f180medium11014
picosulfate sodium0low10
rilmenidine0low30
zoledronic acid0low10
schizandrol b0low10
soquinolol0low10
delta sleep-inducing peptide0low10
brinzolamide0low10
dienogest0medium11
drospirenone0medium51
fluindione0low20
dimethyl itaconate0low10
beta-hydroxyisovaleric acid0medium84
resorufin0low10
fructose-6-phosphate0low30
2,6-dihydroxyacetophenone0low10
perfluorooctanesulfonamide0low10
ethanolamine o-sulfate0low20
tyrosyltyrosine0medium155
5-imidazolepropionic acid0low10
5-hydroxymethylcytosine0low30
n-acetylglutamic acid0low10
2-Methoxyxanthone0low10
n-methylscopolamine0low10
enrofloxacin0low20
cromakalim0low40
atipamezole0low20
uk 687980low10
dapoxetine0medium33
bindarit0low10
hp 8730medium11
tyloxapol0low120
masoprocol0low20
trichlorosucrose0medium238
voriconazole0medium134
prethcamide0low20
adosterol0low10
2-tetradecylglycidic acid0low20
efaroxan0low10
fagomine0low30
hesperetin0medium52
honokiol0low10
sesamin0low30
coptisine0low10
jatrorrhizine0low30
betulin0low10
nobiletin0low120
narciclasine0low20
gentamicin c1a0low10
mesoporphyrin ix0low10
picropodophyllin0low10
alantolactone0low10
beta-amyrin0low20
(-)-catechin0low10
nodakenin0low10
bes0low50
isoalantolactone0low10
doripenem0medium42
strictinin0low10
gliclazide0low10
marrubiin0low20
madecassic acid0low10
panaxadiol0low20
2,5-anhydromannitol0low10
corilagin0low10
bilobalide0low20
maslinic acid0low30
oxazolidin-2-one0medium114
ceric oxide0low30
perfluorooctane sulfonic acid0medium111
monoethyl phthalate0low10
4-aminopyrazolo(3,4-d)pyrimidine0low10
c.i. direct red 800low10
methylimidazoleacetic acid0low10
2-(2-aminoethyl)pyridine0low10
9,9-bis(4-hydroxyphenyl)fluorene0low10
bendamustine hydrochloride0low10
perfluoroundecanoic acid0low10
monomethyl succinate0low10
frovatriptan0low10
rosiglitazone0medium28833
5-hydroxymethyluracil0medium11
4-nitrophenethyl bromide0low30
1-methylxanthine0low30
2-bromopalmitate0low10
bexarotene0low20
s200980low40
noracycline0low10
ro 22-35810low10
3,4-dihydroxyphenylethanol0medium121
vanadium dioxide0low10
propagermanium0low20
4-phenylbutylamine0low20
eriocitrin0low20
acetaminophen sulfate ester0low10
acetaminophen glucuronide0low40
acetaminophen mercapturate0low20
adriamycinol0low20
acetaminophen cysteine0low20
ketorolac tromethamine0low10
clarithromycin0low40
asperuloside0low10
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene0low10
dodecyltriphenylphosphonium0low10
3-bromo-4,5-dihydroxybenzaldehyde0low10
tebuconazole0low10
cholest-5-ene-3,4-diol0low10
we 2010low10
coenzyme a0low230
5-thio-d-glucose0low10
p-chloro-diphenyl diselenide0low10
5,7-dimethoxyflavone0low20
mebeverine0low90
o-desmethylangolensin0low20
nicotine0medium797
nsc-1727550low110
fibrinogen0medium31034
oxazine 10low10
moexipril0medium11
17-alpha-hydroxypregnenolone0low40
equol0medium102
7-ketocholesterol0low10
cholest-4-en-3-one0low10
6-phosphogluconic acid0low10
inermin0low10
3,4-dihydroxyphenylglycol0medium62
glycidamide0low20
homocysteine0medium18620
methylglucoside0low40
8-((4-chlorophenyl)thio)cyclic-3',5'-amp0low10
cadusafos0medium11
delta-tocopherol0low10
sarsasapogenin0low10
1-methylhistidine0medium21
cycloartenol0low10
succinyl-coenzyme a0low10
4-hydroxyphenylglycine0low30
phenylacetylglutamine0low10
zofenopril0low10
melanotan-ii0low210
mci 90380low30
lopinavir0medium83
gamma-tocopherol0medium52
annatto0medium31
21-deoxycortisol0medium11
rac-glycerol 1-monodecanoate0low10
arginine methyl ester0low10
droxidopa0low10
glycidyl nitrate0medium71
isohumulone0medium21
stearoyl-coenzyme a0low30
arabitol0low10
24-methylene cycloartanol0low10
pyrimidine dimers0medium11
6-paradol0low30
diprotin a0low10
glucuronic acid0medium238
2,2',4,4'-tetrabromodiphenyl ether0low30
6-n-propyluracil0low10
phosphoramide mustard0low20
s-(2,4-dinitrophenyl)glutathione0low10
1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid0medium11
delta(9)-tetrahydrocannabinolic acid0low10
n-tert-butylhydroxylamine0low10
diosgenin0low40
isosteviol0low60
alpha-methylhydrocinnamic acid0low10
phorbolol myristate acetate0low10
nimbolide0low10
foxes0low10
enkephalinamide-met, ala(2)-0low10
diphyllin0low10
arctiin0low20
n-hydroxysuccinimide suberic acid ester0low10
tuberostemonine0low10
sesamolin0low30
erythrodiol0low10
zymostenol0medium11
pregnanetriol0low130
cortisol 21-sulfate0low10
n-methyladenosine0medium171
1,2-distearoylphosphatidylethanolamine0low10
lambertianic acid0low10
2,3-bis(4-hydroxyphenyl)-propionitrile0low10
cobalt0medium121
fulvestrant0medium51
hydrogen sulfite0low30
yttrium radioisotopes0medium31
carbidopa, levodopa drug combination0low10
enkephalin, d-penicillamine (2,5)-0low20
vitamin b 60medium222
1,4-dihydropyridine0medium11
imipenem, anhydrous0low10
s-nitrosoglutathione0low30
bosentan anhydrous0low20
cp-55,9400low10
norverapamil0low10
1,n(6)-ethenoadenine0medium33
fructose 2,6-diphosphate0low90
cyanates0low10
pyridinoline0medium31
deoxypyridinoline0medium62
fura-2-am0low10
((18)O)water0low10
3,3'-diiodothyronine0low20
thiamethoxam0medium33
fluorocitrate0low10
cyproterone acetate, ethinyl estradiol drug combination0medium85
sivelestat0low10
propionylcarnitine0low20
methoctramine0low10
1,1-dimethylheptyl-11-hydroxytetrahydrocannabinol0low10
saikosaponin d0low20
perindopril0medium2411
hypotaurine0low10
geniposide0low20
procyanidin0low600
dityrosine0medium11
epicatechin gallate0low30
phosphites0low10
ecopipam0medium11
fingolimod hydrochloride0low90
daidzin0low10
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide0low10
1h-indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1s,2r,3s)-0low10
cobaltiprotoporphyrin0low110
cafestol0low10
proanthocyanidin0low50
parthenolide0medium41
rx 8210020low10
11-hydroxyandrostenedione0low10
benzamil0low10
3,5-dimethyl-3'-isopropyl-l-thyronine0low10
schizandrin b0low40
dynorphin (1-8)0low10
1-hexadecyl-2-acetyl-glycero-3-phosphocholine0low60
deoxyglucose0medium1324
anserine0low10
3-monoiodothyronine0low10
st 5870low10
2,3-bis(3'-hydroxybenzyl)butyrolactone0medium91
homoorientin0low10
kahweol0low20
valerates0medium114
florfenicol0low10
androsterone glucuronide0low40
higenamine0low10
thromboxanes0low100
tanshinone0low70
cinnabarinic acid0low10
11-hydroxytestosterone0low10
1-(carboxymethylthio)tetradecane0low30
toosendanin0low10
geraniin0low30
quadazocine0low10
5-(tetradecyloxy)-2-furancarboxylic acid0low50
dihydro-dids0low10
stachydrine0low10
estrone-3-glucuronide0low10
2-aminobicyclo(2,2,1)heptane-2-carboxylic acid0low10
4-bromo-a-231870low10
nitisinone0low10
perospirone0low10
bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate0low10
bw 373u860low10
marimastat0low10
asiatic acid0low40
obacunone0low20
mono(2-ethyl-5-oxohexyl)phthalate0low10
1'-acetoxychavicol acetate0low10
thiodigalactoside0low30
lithospermate b0low10
dioscin0low30
astilbin0low20
iodofiltic acid0low10
afdx 3840low10
caprylates0medium271
tris(2-carboxyethyl)phosphine0low20
s-lactoylglutathione0low10
ah 68090low10
muricholic acid0low50
pentosidine0low50
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid0low10
medica 160low80
zd 71140low20
l 6924290medium21
mitiglinide0low10
alliin0low20
beta-casomorphin 70low10
betamethasone acetate phosphate0low10
soyasaponin bb0low10
pd 1173020low10
2-n-(4-(1-azitrifluoroethyl)benzoyl)-1,3-bis-(mannos-4-yloxy)-2-propylamine0low20
rc 30950low10
pyroglutamyl-glutamyl-proline amide0low10
pd 1428930low10
brl 351350low110
iodosulpride0low10
pyroglutamyl-histidyl-glycine0low40
pd 1280420low10
astragaloside a0low40
celastrol0low310
procyanidin b20low10
aromadedrin0low10
dehydroacetic acid0low10
carbene0low10
peroxynitrous acid0medium173
perchlorate0low30
fullerene c600low20
imatinib mesylate0medium83
mk 06630low10
tazobactam0medium61
gefitinib0medium43
3,5-diiodothyronine0low70
2,3-bis(3'-hydroxybenzyl)butane-1,4-diol0low40
cdp ethanolamine0low10
7 alpha-hydroxy-4-cholesten-3-one0medium11
acth (4-10)0low20
ru-283620low10
cgp 42112a0low50
deltorphin ii, ala(2)-0low10
phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide0low20
n(6)-carboxymethyllysine0medium51
angiotensin ii, des-asp(1)-des-arg(2)-ile(5)-0low20
n,n-dimethylarginine0medium419
2-(2-(5-carboxy)oxazole)-5-hydroxy-6-aminobenzofuran-n,n,o-triacetic acid0low10
3-(2,2,2-trimethylhydrazine)propionate0low30
interleukin-1beta (163-171)0low10
glycerophosphoethanolamine0low10
n(omega)-hydroxyarginine0low10
hydroxycitric acid0medium214
alanylglutamine0low10
vadimezan0low10
27-hydroxycholesterol0medium71
3-carboxy-4-methyl-5-propyl-2-furanpropionic acid0low20
e 640low10
glabridin0low30
tetrahydrocurcumin0low30
desloratadine0low10
1-o-myristoyl-2-acetyl-glycerol0low10
glycerophosphoinositol 4,5-bisphosphate0low50
3-iodo-n(6)-4-aminobenzyladenosine0low10
msh (11-13)0low10
neominophagen c0low10
cyclo(prolylglycyl)0low30
glicentin0medium72
lvv-hemorphin-70low20
vv-hemorphin-70low10
cgp 476450medium21
methotrexate0medium596
reboxetine0medium41
n-formyl-13-dihydrocarminomycin0low10
s-4-bromobenzylglutathione cyclopentyl diester0low10
ad 50750low20
dihydroethidium0low20
cyanidin0low30
tamsulosin0low10
rufinamide0low10
ly 2436700low50
snp nonapeptide0low10
sulbactam0medium11
olmesartan medoxomil0medium42
ulipristal acetate0medium61
10-methyl spiro(4.5)dec-6-en-6-carboxylic acid0low10
n-methylbenperidol0low20
4-diethoxyphosphorylmethyl-n-(4-bromo-2-cyanophenyl)benzamide0low30
4b,5,9b,10-tetrahydroindeno(1,2-b)indole0low10
n-nor-3-(4'-iodophenyl)tropane-2-carboxylic acid methyl ester0medium21
14-fluoro-6-thiaheptadecanoic acid0medium21
ilomastat0low10
ici d87310low10
n',n''-diacetylspermine0low10
thrombin receptor peptide sfllrnp0low10
omega-n-methylarginine0medium218
hemorphin 70low20
ivabradine0low10
ro 22-06540medium41
febuxostat0medium63
carbapenems0medium73
ly 1067370low10
aspartame0medium389
calcium borate0medium33
bts 54 5050low10
xylose0low160
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone0low10
beta-lactams0medium131
6,6'-bieckol0low20
phytol0low20
sinensetin0low10
proline0medium432
cucurbitaceae0low90
eckol0low10
4-(3-(bis(beta-hydroxyphenethyl)amino)butyl)benzamide0medium52
ici 1182330low10
acetyl 4-aminosalicylic acid0low10
drospirenone and ethinyl estradiol combination0low10
docetaxel anhydrous0medium189
perifosine0low10
levofloxacin0medium21
malagashanine0low10
ezetimibe0medium3516
ertapenem0medium51
3,3',4',5,6,7,8-heptamethoxyflavone0low20
4-methoxy-2-naphthylamine0low10
threonic acid0low10
conivaptan0low10
cariporide0low30
mk 7670low40
vatalanib0low10
evodiamine0low40
2-chloro-2-deoxyglucose0low10
dihydrophylloquinone0low10
histidylproline0low10
imidazole-4-carboxamide0low10
moxifloxacin0medium22
borneo0low10
ruboxistaurin0low30
jtt 5010low50
bazedoxifene0medium31
phorbols0low10
aurantio-obtusin0low20
4-methoxyhonokiol0low20
schizandrin a0low10
cyanopindolol0low10
atractylenolide iii0low10
ym 09151-20low10
naproxen0medium61
cinacalcet0low40
echinoside a0low20
ertiprotafib0low20
hydroxyl radical0medium81
bis(4-piperidinophenol)diimidonaphthalene-1,4,5,8-tetracarboxylic acid dibenzosulfoethylate0low20
atazanavir sulfate0low20
olmesartan0medium226
talibegron hydrochloride0low10
rhodioloside0low30
torcetrapib0low20
atrasentan0low30
androsterone sulfate0low10
zinc selenite0low10
4-guanidinobenzoate0low10
singlet oxygen0low10
fidarestat0low30
cryptotanshinone0low10
cyc 2020low40
3,5-dimethoxy-4'-hydroxystilbene0low10
3,5-diiodothyropropionic acid0low10
cannabidiolic acid0low10
7,8-dihydro-5,6-dehydrokawain0low10
sweroside0low10
prostaglandins b0low10
columbianetin acetate0low10
ampelopsin0low50
myricanol0low10
ag 3-50low20
desacetyl cephapirin0low10
isovitexin0low10
platycodin d0medium41
sclareol0low10
4-trifluoromethylsalicylic acid0medium21
methylinositol0medium31
calcium pyrophosphate0low10
tartrazine0low10
tetraphenylphosphonium0low10
anidulafungin0low20
avasimibe0low10
technetium tc 99m pentetate0low40
clorazepate dipotassium0low10
anacardic acid0low10
udp-glucosamine0low10
tetrahydroaldosterone 3 beta-glucosiduronic acid0low10
mahanimbine0low20
lauroylcarnitine0low10
boswellic acid0low10
symmetric dimethylarginine0low40
aminopterin0low10
17 alpha-hydroxyprogesterone caproate0medium62
mono(2-ethyl-5-hydroxyhexyl) phthalate0low10
varenicline0medium95
farglitazar0low20
isomhpg0low10
biotin0low90
angiotensin ii0medium2036
campesterol0medium71
ly 797710low30
atropine0medium486
galactosucrose0low10
7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acid0low10
lignin0low90
ropivacaine0medium62
migalastat0low10
sb 2035800low90
sb 2167630low10
zm 2413850low10
erlotinib hydrochloride0medium11
4'-o-methylepigallocatechin0medium11
lu 1352520low20
organophosphonates0low50
psyllium0medium189
5-heptadecylresorcinol0low30
esketamine0medium11
tak 7790low10
melagatran0medium11
scutellarin0low10
propargylglycine0low40
dihydroresveratrol0low10
glycitin0low10
alpha-fluoromethylhistidine0low10
isospaglumic acid0low30
alisol b0low20
loureirin b0low10
deflazacort0low30
7-oxodehydroepiandrosterone0low20
20-hydroxy-3-oxo-4-pregnen-21-carboxylic acid0medium11
6-dodecyl-2-methoxy-1,4-benzoquinone0low10
n(2)-(gamma-d-glutamyl)-meso-2,2'-diaminopimelic acid0low10
somatostatin, octapeptide-trp(8)-0low10
1-((4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl)-4-methylpiperazine0low10
rs 1274450low10
macrostemonoside a0low10
cgp 546260low10
n-propionylprocainamide0low10
cadmium metallothionein0low10
pronuciferine0low10
mcc-5550low20
muraglitazar0low10
dronedarone0low10
tesaglitazar0low40
ramelteon0medium11
2-(4-morpholinoanilino)-6-cyclohexylaminopurine0low10
darunavir0low10
deferasirox0low10
dabigatran0medium211
tolvaptan0low20
sorafenib0low30
alagebrium0medium21
lenalidomide0low20
solifenacin succinate0low10
beta-methyl-6-chloromelatonin0low10
regadenoson0medium22
cholic acid0low120
erythritol0medium93
delrin0low20
estradiol 3-benzoate0low20
cortisone0medium1005
adrenosterone0low10
norethindrone enanthate0low30
1,1-bis(4-hydroxyphenyl)cyclohexane0low20
3-nitrotyrosine0medium352
5-hydroxymethylfurfural0medium11
sodium sulfide0low10
stigmastanol0low10
epimestrol0low10
lanosterol0medium21
2-hydroxyestradiol0low20
nsc 748590low10
pheophorbide a0low10
anisomycin0low20
benzofurans0medium242
sodium bromide0low30
corticosterone acetate0low10
nas0low10
withaferin a0medium101
esi-050low10
noscapine0low10
4-methoxyxanthone0low10
wortmannin0low170
ibogaine0low40
withanolides0low90
rocaglamide0low10
trimethoprim, sulfamethoxazole drug combination0medium32
o-(chloroacetylcarbamoyl)fumagillol0low40
taurochenodeoxycholic acid0medium281
bortezomib0low10
ritonavir0medium83
jib-040low10
acetogenins0medium11
mrs 12200low10
Bardoxolone0low10
bardoxolone methyl0medium61
dihydropyridines0medium127
lanatosides0low10
povidone-iodine0medium21
permanganate0medium33
4-aminopiperidine0low10
leupeptins0low40
carboplatin0medium267
lithium chloride0low130
eurycomanone0low10
s-adenosylhomocysteine0low30
glyceraldehyde 3-phosphate0low10
glycogen0medium34610
sorbose0low10
arabinose0low70
n-acetylneuraminic acid0medium182
fibrin0medium202
bradykinin0medium236
amylopectin0low20
elastin0low110
carnosine0medium144
mevalonic acid0medium111
raffinose0low30
naringenin0medium183
epiglucan0medium5912
diaminopimelic acid0low10
d-tagatose0low50
pantetheine0low30
theanine0low20
inositol 1,4,5-trisphosphate0low70
cysteinylglycine0medium21
ouabain0low400
salicin0medium11
casein hydrolysate0medium82
puromycin0low40
taxifolin0low40
xylobiose0low10
isomaltulose0medium43
desmosterol0low30
alpha-aminobutyric acid0low30
n'-formylkynurenine0low10
nicotinamide-beta-riboside0medium154
nitroarginine0low50
mannosamine0low10
inositol 3-phosphate0low60
1-o-indol-3-ylacetylglucose0low10
2-hydroxyestrone0medium11
cortodoxone0medium41
fructans0medium142
cellulase0low10
psicose, (d)-isomer0medium221
meropenem0medium71
griseofulvin0low10
cefoxitin0medium41
digitoxin0low100
pancuronium0low40
rocuronium0medium166
hyperforin0low20
miglitol0medium196
mometasone furoate0medium11
linezolid0medium123
phalloidine0medium11
indican0low20
ryanodine0low20
ginsenoside re0medium41
ginsenoside rg10low50
notoginsenoside r10low10
stevioside0low50
lenticin0low10
decursin0low10
lactucin0low10
micheliolide0low10
genipin0low70
naringin0medium91
swertiamarin0low30
ochratoxin a0low20
gingerol0low100
alpha bitter acid0low10
cyclopamine0low10
lignans0medium332
acriflavine0low10
bq 1230medium153
n-formylmethionine leucyl-phenylalanine0low20
geniposidic acid0low10
devazepide0low20
clindamycin phosphate0low10
sodium arsenite0low20
daunorubicinol0low20
mepirodipine0medium11
eplerenone0medium162
temocapril hydrochloride0low30
ergonovine0low10
dironyl0low80
tibolone0medium43
ao 1280medium163
sultamicillin0medium11
betadex0low50
acetyl coenzyme a0low220
trichostatin a0low30
tretinoin0medium494
arachidonic acid0medium988
alpha-cyclodextrin0medium21
farnesol0low20
3-hydroxy-3-methylglutaryl-coenzyme a0low40
resveratrol0medium23021
retinol0medium23116
cyanoginosin lr0low10
palmitoleic acid0medium282
oleic acid0medium14917
tacrolimus0medium403
farnesyl pyrophosphate0low10
ferulic acid0medium131
pectins0medium365
cerivastatin0medium31
cocaine0medium719
thapsigargin0low150
mycophenolic acid0low140
clindamycin0low80
keratan sulfate0medium42
gw 64710low30
lycopene0medium335
fosfomycin0medium21
drf 27250low20
gw 39650low40
t09013170low80
y 276320low30
prostaglandin d20low100
diethylstilbestrol0medium241
epothilone a0medium11
eptifibatide0medium22
cp-6401860low10
h 890low10
gs 40710medium33
imidazolidines0low50
decitabine0low30
pantethine0low20
steviol0low20
iridoids0low160
troxacitabine0low10
laminaran0low10
cefamandole0low10
dactinomycin0low110
gamma-sitosterol0medium102
melphalan0medium91
enkephalin, leucine0medium241
benzyloxycarbonylleucyl-leucyl-leucine aldehyde0low40
tenofovir0medium101
schizandrin0low10
posaconazole0medium21
l 743,8720low50
ganoderic acid a0low10
cinnamtannin b-10low10
micafungin0medium51
acetylshikonin0low30
shikonin0low10
6,8-diprenylgenistein0low10
favipiravir0low10
riboflavin0medium273
maltitol0medium11
lisofylline0low20
rubrofusarin gentiobioside0low10
8-isopentenylnaringenin0low10
2,3-bis(bromomethyl)quinoxaline-1,4-dioxide0medium33
isoxanthohumol0low10
5-fluoro-2'-deoxycytidine0medium11
sodium bicarbonate0medium92
potassium bicarbonate0medium22
potassium perchlorate0low10
sodium acetate, anhydrous0low20
sodium benzoate0low10
3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-n-oxyl0low10
dipyrone0medium11
sodium perchlorate0low10
thiacremonone0low10
bromochloroacetic acid0low50
pyrrolopyrimidine0low10
1,3-bis(3,5-dichlorophenyl)urea0low10
carbenoxolone sodium0medium161
alpha-asarone0low10
calebin-a0low10
cinnamaldehyde0low80
elaidic acid0low40
trans-4-coumaric acid0low40
anethole0low10
geraniol0low10
dimethyl fumarate0low20
glycosides0medium321
chalcone0medium61
sinapinic acid0low10
isomethyleugenol0medium501
citral0low30
retinaldehyde0low50
piperine0medium81
retinol acetate0low20
squalene0medium121
stilbenes0medium18114
isoliquiritigenin0low20
xanthohumol0low100
4'-methoxychalcone0low10
xanthoangelol0low10
flavin-adenine dinucleotide0low10
cannabidiol0low140
malonyl coenzyme a0low420
buprenorphine0low40
lypressin0low50
arginine vasopressin0medium392
pyrophosphate0low30
palmitoyl coenzyme a0low150
gw96620low110
s 10330low10
dihydrosphingosine 1-phosphate0low10
methylatropine0low30
omapatrilat0low10
iothalamate meglumine0low10
tropisetron0low20
benidipine0low30
sodium metabisulfite0medium11
tram 340low10
isopropyl thiogalactoside0medium11
fludarabine0low20
propylthiouracil0medium244
nsc 43470low60
n(6)-cyclopentyladenosine0low10
sesquiterpenes0medium356
etomidate0low20
mercaptopurine0low60
methylthiouracil0low10
3,3',4,5'-tetrahydroxystilbene0low40
alpha-methyltryptophan, (l)-isomer0low10
phenylthiourea0low10
dehydrovomifoliol0low10
caffeic acid0low100
n-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide0low10
cotinine0medium202
rhododendrol0low10
eszopiclone0low20
dieldrin0low30
curcumin0medium12320
nootkatone0low20
2-thioxanthene0low10
methimazole0low50
urb 5970low10
sulindac0medium42
capsaicin0medium10013
aurapten0low20
oxazolone0low10
ac 556490low10
chlorogenic acid0medium352
thioguanine anhydrous0low30
thiobarbituric acid0medium11
thiourea0low80
safranine t0low10
indigo carmine0medium21
D-fructopyranose0medium68662
thioacetamide0low30
unithiol0low10
tempo0medium42
5-doxylstearate0low10
succimer0low10
digoxin0low280
meso-1,2-diphenylethylenediamine, (r-(r*,s*))-isomer0medium11
capsazepine0low10
fumonisin b10low20
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole0low10
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide0low10
tamoxifen0medium6410
nadp0medium451
1,1-diphenyl-2-picrylhydrazyl0low40
hc-0670470low10
jnj-52078520low10
4-hydroxyisoleucine0low20
t 00709070low10
stattic0low10
krn 70000low60
methyl-thiohydantoin-tryptophan0low20
psn 3759630low10
kl0010low10
thiopental0medium212
estrone sulfate0low40
ranitidine0medium73
maraviroc0low40
u 01260low70
femoxetine0medium32
l 7832810low20
pica0low60
lithium0medium606
goitrin0low10
cobaltous chloride0medium41
nitrogen dioxide0medium264
hydroxylysine0low10
nizatidine0medium53
altanserin0low10
dolasetron0low10
gestodene0medium22
quinine0low180
azoxystrobin0low10
6-thioguanylic acid0low10
androstane-3,17-diol glucuronide0medium101
ici 1541290medium11
rtki cpd0low10
brassinin0low10
amibegron0low30
bis(maltolato)oxovanadium(iv)0low40
thioperamide0low30
cystine0medium102
u-504880low10
ospemifene0low10
sch 233900low20
ym3480low10
ro 60-01750low10
myristoyllysophosphatidylcholine0medium11
freedom0medium161
rivoglitazone0low20
glucitol hexanicotinate0low10
safingol0low20
4-(3-3,4-p-menthadien-(1,8)-yl)olivetol0low10
dasatinib0low50
s 152610low10
carbonyl 3-chlorophenylhydrazone0low10
1-deoxynojirimycin 4-o-alpha-d-glucopyranose0low10
telavancin0low10
2-fluoro-2-deoxyglucose-6-phosphate0medium11
nitinol0low20
n-(ethoxycarbonylmethyl)-6-methoxyquinolinium0low10
dakh peptide0low20
sanorg 340060medium11
amanitins0low10
cytellin0medium153
ginsenosides0medium352
2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine0low10
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline0low10
ovalbumin0medium441
gw 76470low30
sodium dodecyl sulfate0medium11
sto 6090low10
crocin0low40
galactomannan0low20
3-(1-adamantyl)-6,7,8,9-tetrahydro-5h-(1,2,4)triazolo(4,3-a)azepine0low10
sb 2420840low20
l 6635360low30
flavan-3-ol0low40
l 1528040low20
zinc protoporphyrin ix0low20
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3h)-quinazolinone0low40
alpha-chymotrypsin0low50
sew28710low10
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione0medium11
sb 4152860low10
17-ketosteroids0medium1531
naphthoquinones0low60
jhw 0150low10
am 6300low10
sc 5600low10
hydroxyethylcellulose0low10
alpha-carotene0medium91
osteoprotegerin0medium523
cathepsin g0low20
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol0low50
icodextrin0low10
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide0low20
4-cresol sulfate0low10
imd 03540low10
2-mercaptoacetate0low10
ex 5270low20
3-hydroxychromone0low10
tetrathiomolybdate0low10
diethyl maleate0low10
5,6-dehydrokawain0low10
quercetin 3-o-glucuronide0low10
catechin gallate0low10
gallocatechin-3-gallate0low30
jtk-3030low10
sphingosine0low310
quercetin0medium1038
ubiquinone q20low10
bilirubin0medium758
dinoprostone0medium673
dinoprost0medium8912
biochanin a0low40
formononetin0low40
prostaglandin b10low10
vitexin0low40
acacetin0low30
apigenin0low160
luteolin0medium201
7,3'-dihydroxy-4'-methoxyisoflavone0low10
calcitriol0medium758
scopoletin0low10
vomifoliol0low10
ubiquinone 90medium31
vitamin k semiquinone radical0medium373
beta carotene0medium637
11-cis-retinal0low60
leukotriene b40low110
leukotriene c40low10
thromboxane a20medium121
retinol palmitate0medium122
feruloyltyramine0low10
herbacetin0low10
hymecromone0low30
daphnetin0low10
8,11,14-eicosatrienoic acid0medium152
luteolin-7-glucoside0low10
rumenic acid0low40
15-keto-13,14-dihydroprostaglandin e20low10
15-ketoprostaglandin e20low10
alprostadil0low50
5-hydroxy-6,8,11,14-eicosatetraenoic acid0low20
stigmasterol0low40
quercetin 3-o-glucopyranoside0low10
rutin0low210
kaempferol0low120
leukotriene d40low10
leukotriene e40low60
6-ketoprostaglandin f1 alpha0medium101
11-dehydro-thromboxane b20medium51
arachidonic acid omega-9 hydroperoxide0low10
zeaxanthin0low150
lipoxin a40low80
gamma-linolenic acid0medium133
alpha-linolenic acid0medium7417
harmine0low20
genistein0medium503
amphotericin b0low80
pulmicort0medium21
oxymetholone0low10
pyrvinium0low10
montelukast0medium52
mivacurium0low10
kava0low10
erucic acid0low10
nervonic acid0low30
cyclobenzaprine0low30
11-octadecenoic acid0medium101
butein0low40
astaxanthine0medium222
capsanthin0low10
cryptoxanthins0medium142
fucoxanthin0medium371
lutein0medium193
norbixin0low10
sulfuretin0low20
nsc 1063990low10
5,7-dihydroxychromone0low10
esculetin0low20
esculin0low10
pteryxin0low10
humulene0low410
petasin0low10
oleuropein0low70
garcinol0low20
zearalenone0low10
baicalein0medium103
chrysin0low50
diosmetin0low10
diosmin0low20
fisetin0low70
galangin0low20
hispidulin0low10
euxanthone0low10
hyperoside0low20
mangiferin0low50
mangostin0low50
3-methylquercetin0low30
norathyriol0low10
kaempferide0low10
morin0low30
myricetin0low70
myricitrin0low10
scutellarein0low10
tricin0low10
wogonin0low10
coumestrol0low10
daidzein0medium131
trans-2,3',4,5'-tetrahydroxystilbene0low20
pterostilbene0low140
epsilon-viniferin0low30
gingerenone a0low10
caffeic acid phenethyl ester0low50
rosmarinic acid0low20
salvianolic acid a0low10
shogaol0low40
acteoside0low20
orobol0low10
prunetin0low10
wedelolactone0low10
wighteone0low10
maytansine0low10
rottlerin0low10
ellagic acid0medium81
soraphen a0low30
coenzyme q100medium184
tectochrysin0low10
anandamide0medium655
cerulenin0low40
astragalin0low10
n-oleoyldopamine0low10
alpha-ionone0low10
cilnidipine0medium21
geranylgeranylacetone0medium11
tranilast0low10
8-epi-prostaglandin f2alpha0medium617
glyceryl 2-arachidonate0medium514
ssr 125543a0low10
tocotrienol, delta0low20
11-ketotestosterone0low10
etretinate0low20
isotretinoin0low50
fondaparinux0medium111
pitavastatin0medium103
9,11-linoleic acid0low90
trans-10,cis-12-conjugated linoleic acid0medium111
10,12-octadecadienoic acid0low10
9-hydroxy-10,12-octadecadienoic acid0medium41
13-hydroxy-9,11-octadecadienoic acid0medium31
traumatic acid0low10
15-keto-13,14-dihydroprostaglandin f2alpha0low30
meteneprost0medium11
16,16-dimethylprostaglandin e20medium21
2,3-dinor-6-ketoprostaglandin f1alpha0low10
prostaglandin f2 methyl ester0low10
thromboxane b20medium235
14,15-dihydroxyeicosatrienoic acid0low10
20-hydroxy-5,8,11,14-eicosatetraenoic acid0medium92
5,6-epoxy-8,11,14-eicosatrienoic acid0low10
4-hydroxy-2-hexenal0low10
4-hydroxy-2-nonenal0low410
oleylamide0low20
linoleoyl ethanolamide0low20
n-oleoylethanolamine0medium415
1-monooleoyl-rac-glycerol0low10
ubiquinone 80medium11
menaquinone 60medium74
sphingosine 1-phosphate0low260
n-palmitoylsphingosine0low40
ceramide 1-phosphate0low10
cholesteryl oleate0low20
fucosterol0low10
hyodeoxycholic acid0low10
codeine0low20
phenylephrine hydrochloride0medium212
acitretin0low40
cyproterone0low40
dihydrocodeine0low10
diminazene aceturate0low10
granisetron0medium11
hydrocodone0low20
hydromorphone0medium31
levetiracetam0low20
nabilone0medium11
nalmefene0low40
nalorphine0low10
methylestrenolone0low10
oxycodone0medium62
vitamin k 10medium51
sirolimus0medium727
trospium chloride0medium11
3',4',7-trihydroxyisoflavone0low20
gamma-cyclodextrin0low10
menaquinone 70medium44
brefeldin a0low20
alvocidib0low10
fenretinide0low70
topiroxostat0low20
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin0low10
lobeline0low10
as 6052400low10
xylulose0low10
acipimox0medium3016
adp beta s0low10
benzphetamine0medium121
beta-funaltrexamine0medium31
bibo 34570low40
bibp 32260low30
bimatoprost0low30
clobetasol0low10
cloprostenol0low20
deamino arginine vasopressin0medium81
desoximetasone0low10
sb 2770110low10
fluticasone0low20
goserelin0medium21
iloprost0low30
15-deoxy-delta(12,14)-prostaglandin j20low30
lacidipine0medium11
ono-ae1-3290low10
lysophosphatidic acid0medium211
lysophosphatidylcholines0medium324
mdl 1009070low120
n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester0low10
cytochalasin b0low80
nateglinide0medium71
neurokinin a0low10
neurokinin b0medium181
pd 1233190low70
pholcodine0low10
11-dehydrocorticosterone0low20
sq 307410low10
sq 295480low80
cl 3162430low550
silodosin0low10
sb 2710460low10
5,9,12-octadecatrienoic acid0low20
stearidonic acid0medium51
decaprenoic acid0low10
10-hydroxy-2-decenoic acid0low10
1,2-oleoylphosphatidylcholine0low10
biliverdine0low20
bisdemethoxycurcumin0low10
cannabigerol0low10
cinnamyl alcohol0low20
collinin0low10
corylin0low20
syringin0low10
glycitein0low10
calycosin-7-o-beta-d-glucopyranoside0low10
andrographolide0low30
isopetasin0low10
isorhamnetin 3-o-glucoside0low10
icariin0low10
licochalcone a0low20
ligustilide0low10
4-methylesculetin0low10
3'-o-methylorobol0low10
2-oleoylglycerol0medium33
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one0low10
tiliroside0low20
quercetin 3-o-gentiobioside0low10
sophoricoside0low10
caryophyllene0medium61
fluvoxamine0medium54
fexaramine0low30
casein kinase ii0low50
ag-4900low50
su 112480low30
palbociclib0medium31
gsk 47160low10
nifuroxazide0low10
fosbretabulin0medium11
lead0medium395
tin0low20
butylidenephthalide0low10
11-hydroxy-5,8,12,14-eicosatetraenoic acid0low10
12-hydroxy-5,8,10,14-eicosatetraenoic acid0low60
6,7-dihydroxyflavone0low50
bay 11-70850low20
pd 1517460low10
15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid0low60
methyl-3-methoxy-4-hydroxystyryl ketone0low10
barium0medium51
8-oxo-7,8-dihydrodeoxyguanine0low10
oleylamine0low10
rubidium0low160
aluminum0low70
strontium0medium51
bismuth0low10
levallorphan0low10
thallium0low10
arsenic0medium324
morphine-6-glucuronide0medium11
dextromethorphan0low20
butorphanol0medium22
delapril0medium21
lisinopril0medium165
benazepril0medium21
ramipril0medium206
batimastat0low10
sulfur0medium191
zimeldine0medium21
costunolide0low10
dehydrodiconiferyl alcohol0low10
n-(4-hydroxy-beta-phenethyl)-4-hydroxycinnamide0low10
plastoquinone0low20
1-hydroxyxanthone0low10
diphenylhexatriene0low40
jaceosidin0low10
urolithin b0low20
simmondsin0low20
puerarin0medium61
eleostearic acid0low30
ajoene0low10
3,4',5-trimethoxystilbene0low20
enalapril0medium3110
ternatin (flavonoid)0low10
dimyristoylphosphatidylcholine0low10
ecdysterone0low50
deoxyribose0low10
fumarates0medium175
beryllium0low20
cysteine0medium764
thyronines0medium101
silicon0low20
thallium-2010low10
phosphorus0medium786
boron0low90
heroin0low50
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid0medium32
imidapril0low20
zerumbone0low10
bergamottin0low10
artepillin c0low50
cinanserin0low10
ximelagatran0medium22
cefepime0medium31
l 6854580low10
norbinaltorphimine0low30
ici 1185510low30
trandolapril0medium96
morphine-3-glucuronide0medium21
enkephalin, ala(2)-mephe(4)-gly(5)-0low30
stercobilin0low10
troxerutin0low20
enkephalinamide-leu, ala(2)-0low10
pregabalin0medium21
tiotropium bromide0low20
3,8-dihydroxy-6h-dibenzo(b,d)pyran-6-one0low60
uroguanylin0medium101
baohuoside i0low10
vitexin rhamnoside0low10
guanylin0medium71
aliskiren0medium115
isocoumarin nm-30low10
oleoyl-coenzyme a0low20
triolein0medium221
docosapentaenoic acid0medium61
gedunin0low10
guanabenz0low20
bafilomycin a0low20
resiniferatoxin0low20
abscisic acid0low50
carbocyanines0low10
25-hydroxyvitamin d 20medium277
salubrinal0low20
cefotaxime0low20
semapimod0low20
3,4-dihydroxy-xanthone0low10
cladrin0low10
1-(2-(diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine0low10
cinidon-ethyl0low40
ammonium sulfate0low10
magnesium citrate0medium11
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid0low20
am-3560low20
ma-10medium11
monorden0low10
coomassie brilliant blue0low10
tetrodotoxin0low10
germanium0low20
selenium0medium895
selenocysteine0low10
tellurium0medium83
radium0low110
oxalates0medium753
aluminum hydroxide, magnesium hydroxide, drug combination0low10
alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination0medium31
palonosetron0medium21
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid0medium102
dtpp0low20
maxacalcitol0low10
dihydroergotoxine0low10
dizocilpine maleate0low10
antimycin a0low30
10-hydroxynortriptyline0low10
pregnanediol0medium101
cholestanol0medium41
simethicone0low30
aminorex fumarate0low10
flupenthixol decanoate0low10
24,25-dihydroxyvitamin d 30low40
vitamin a20low10
bafilomycin a10low40
germacrone0low10
4-methylumbelliferyl oleate0low10
hesperidin methylchalcone0low20
1-oleoyl-2-acetylglycerol0low20
1,2-dioleoyloxy-3-(trimethylammonium)propane0low10
(2e,4e,6e,10e)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid0low30
sphingosine phosphorylcholine0low10
brl 26830a0medium215
plastochromanol 80low30
viprostol0low10
thermozymocidin0low70
4-hydroxyderricin0low10
2-cyano-3-(1-phenylindol-3-yl)acrylate0low10
plethoryl0low30
carbocyanine dye diic12(3)0low10
4-o-carboxymethylascochlorin0low40
bw a14330low30
17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid0low40
n,n,n-trimethylsphingosine0low10
gp 40low10
5-hydroxy-6,8,11,14,17-eicosapentaenoic acid0low10
14-hydroxydocosahexaenoate0low40
pregna-4,17-diene-3,16-dione0low30
disufenton sodium0low10
amorphastilbol0low10
feruloyltyramine, (z)-isomer0low10
sanshool0low10
everolimus0medium62
bifenthrin0low10
12-hydroxy-5,8,10,14,17-eicospentaenoic acid0low30
hydroxysafflor yellow a0low20
ixabepilone0medium11
rosiglitazone-metformin combination0medium32
b 12870low10
axitinib0medium33
cgp-566970low10
pai 0390low60
ibutamoren mesylate0medium75
salvianolic acid B0low40
i(3)so3-galactosylceramide0low40
salacinol0low10
rilpivirine0low10
trilobatin0low10
glucuronyl glucosamine glycan sulfate0low10
hylin0low10
beta-escin0medium61
panduratin a0low20
gw 19290low60
beta-escin0medium822
glucoraphanin0low30
4,5-diaminofluorescein diacetate0low10
l-1650410low10
s-nitroso-n-acetylpenicillamine0low40
5-(4-phenylbutoxy)psoralen0low10
sb 334867-a0low80
caviunin0low10
echinocystic acid0low10
n-stearoyltyrosine0low10
butylscopolammonium bromide0low10
gadolinium dtpa0medium61
morphinans0medium21
ergoline0medium83
carboxyl radical0low10
sq-233770low20
adenosine 5'-phosphorothioate0low10
fumagillin0medium51
enkephalin, leucine-2-alanine0low20
etonogestrel0medium113
tiapamil hydrochloride0low10
glunicate0low10
beraprost0low20
ginsenoside rb20low10
u 628400low10
dutasteride0medium42
hexarelin0medium81
bay 12-95660low10
oleoyl-estrone0low240
beta-elemene0low10
isavuconazole0low20
lu 2080750low10
jwh-1330low10
vildagliptin0medium334
talabostat0low10
bvt27330low10
corosolic acid0low20
xct7900low10
rebaudioside a0medium131
staurosporine0low50
aminomethyltransferase0low10
loa0low10
1,25-dihydroxyergocalciferol0low10
hypericum0low60
phosphocreatine0medium182
19-norandrosterone0low10
taxane0medium52
chlorhexidine0medium62
formazans0low10
s 17430low10
tri-cyclen0medium22
gs-73400low30
desacetylcefotaxime0low10
naloxonazine0low10
triacsin c0low30
methylglyoxal bis(butylamidinohydrazone)0low10
s-allylcysteine0low10
s-allylmercaptocysteine0low10
iniparib0low10
2-hydroxy-9-cis-octadecenoic acid0low20
nnc 38-10490low10
dibutyl phthalate0low10
gw 3116160low10
gw 5015160medium91
lipstatin0low20
bay 58-26670low20
amoxicillin-potassium clavulanate combination0low10
neotame0low10
biie 02460low10
bms3455410low10
norfenfluramine0low10
butabindide0low10
valyl-prolyl-proline0low20
benzonitrile, 4-(2-(2-((2r)-2-methyl-1-pyrrolidinyl)ethyl)-5-benzofuranyl)-0low10
spc-8390low20
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin0low10
lenvatinib0low10
rosavin0low10
sergliflozin etabonate0medium21
lobeglitazone0low20
gw 8034300low30
tzd 180low10
midostaurin0low10
l 7555070low10
omacor0medium54
ro 28-26530low10
ezetimibe, simvastatin drug combination0medium11
sincalide0medium464
efavirenz, emtricitabine, tenofovir disoproxil fumarate drug combination0low10
tapentadol0low10
capsiate0medium31
fructosyl-lysine0low10
etomoxir0medium71
brl 373440low40
ml 002537640low10
11-keto-boswellic acid0low10
qsymia0low130
ursodoxicoltaurine0medium251
cgp 71683 a0low10
ginsenoside m10medium41
paliperidone palmitate0medium51
sr 1461310low10
ppi-09030medium42
bms2010380low20
pentagastrin0low60
cangrelor0medium11
flag peptide0low30
gc 1 compound0low40
kb 1410low30
gft5050low10
mocetinostat0medium533
mirabegron0medium93
t-2262960low50
alloin0low20
3-(2,4-dichlorobenzyl)-2-methyl-n-(pentylsulfonyl)-3 h-benzimidazole-5-carboxamide0low20
gw 95780low30
gw 78450low10
ticagrelor0medium31
rivaroxaban0medium332
lipid a0low90
4-methylene-2-octyl-5-oxofuran-3-carboxylic acid0low130
pi1030low10
sr 59230a0low30
balaglitazone0low10
ngb 29040low10
l 7964490low20
gw 40640low60
shu 91190low230
ginsenoside rb10low100
g(m2) ganglioside0low20
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide0low20
psd 5020medium11
secoisolariciresinol diglucoside0low20
theasaponin e10low10
sorbitan monooleate0medium43
tofacitinib0low30
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide0low10
tocotrienols0medium171
n-(4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochloride0low20
l 7060000low10
gw07420low50
3-chloro-4-(3-(7-propyl-3-trifluoromethyl-6-benzisoxazolyl)propylthio)phenylacetic acid0low10
eht 18640low10
sr 142948a0low10
bremelanotide0low10
s 56820low10
zeolites0medium21
pitolisant0medium53
ps11450low20
3-iodothyronamine0low30
bay 41-85430low10
2-iodophenyl-(1-(1-methylpiperidin-2-ylmethyl)-1h-indol-3-yl)methanone0low10
chir 990210low10
nuvaring0low20
ubiquinol0low10
vortioxetine0low10
4-hydroxyestrone0low10
aluminum oxide0low10
rs 1028950low20
cgp 20712a0medium41
bisdehydrodoisynolic acid0low10
2-(2-(4-phenoxy-2-propylphenoxy)ethyl)indole-5-acetic acid0low20
fidaxomicin0low10
3'-hydroxypterostilbene0low10
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane0low30
pimavanserin0low10
vorapaxar0low10
2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone0low10
linagliptin0low160
fmrfamide0low10
cystathionine0low30
tribulus0low20
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole0low40
am 12410low10
prasugrel hydrochloride0medium41
dimethylarginine0medium163
apixaban0medium132
delphinidin 3-sambubioside0low10
sargahydroquinoic acid0low10
tasimelteon0low10
struvite0low10
jte 0130low10
int 1310low10
18-methoxycoronaridine0low30
aleglitazar0low10
edoxaban0medium52
trans-sodium crocetinate0low30
kb 21150low10
alpha-synuclein0low70
bavachinin0low10
angiotensin amide0low30
neuromedin u 80low10
eugenosedin-a0low10
2-furoyl-ligrlo-amide0low10
triptohypol C0low10
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone0low10
3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile0low20
ipragliflozin0low160
etc-10020low10
5s,12r,18r-trihydroxy-6z,8e,10e,14z,16e-eicosapentaenoic acid0low40
isotocin0medium11
oxadiazoles0low270
4,5-diaminofluorescein0low10
androstan-17-one0low10
baci-im0low10
artemisic acid0low10
hydroxymatairesinol0low10
ribose0low30
decabromodiphenyl ethane0low30
acebutolol0medium122
lactulose0medium156
schisandrol a0low10
l-altro-1-deoxynojirimycin0low10
oleanderolide0low10
regorafenib0medium11
ly32010low10
siphonaxanthin0low20
wp10660low10
ptc 1240low20
epoxomicin0low10
tedizolid0medium11
brimonidine tartrate0low60
mbx-80250low10
lurasidone hydrochloride0medium21
procyanidin b10low10
lucidone0low10
fucoxanthinol0low30
buprenorphine, naloxone drug combination0low20
cenicriviroc0low10
triglycerides0low10
pf 5142730low10
mk 28660low10
er-0865260low10
resolvin d20low10
mitoquinone0low110
technetium tc 99m disofenin0medium21
alogliptin0medium61
psn 6324080low10
mk-94700low10
mk-05570medium43
snap79410low20
dorsomorphin0low90
ulimorelin0low10
chlorocitric acid0low10
anacetrapib0medium31
apremilast0medium21
mk-08930low10
VPC 230190low10
sitagliptin phosphate0medium5212
gw95080low20
jtt 1300low50
2,4,3',5'-tetrahydroxystilbene0medium11
cefdinir0low10
ginsenoside rd0low20
bay 60-65830low10
2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine0low10
losartan potassium0medium321
d-arg-dmt-lys-phe-nh20medium31
ginsenoside ro0low10
2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose0low20
n-acetylmannosamine0medium21
3-epioleanolic acid0low10
empagliflozin0medium386
lc15-04440medium11
octanoylcarnitine0low10
palmitoylcarnitine0low60
technetium tc 99m exametazime0medium32
calcimycin0low50
dextrothyroxine0medium31
veliparib0low10
ferryl iron0low10
sepharose0low40
indocyanine green0low60
scopolamine hydrobromide0medium11
pituitrin0medium681
n4-(2,2-dimethyl-3-oxo-4h-pyrid(1,4)oxazin-6-yl)-5-fluoro-n2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine0low10
1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol0low10
ar 92810low10
monascin0low20
phytosterols0medium5110
enerbol0low20
glycoursodeoxycholic acid0low30
dihydrotachysterol0low10
nomilin0low20
oleanonic acid0low20
clove0low170
ginsenoside rh10low10
acid phosphatase0low240
ants0low10
1,3-distearoyl-2-oleoylglycerol0low10
tetrahydrouridine0medium11
chikusetsu saponin iva0low10
grasshopper ketone0low10
astragaloside IV0low10
23-hydroxyursolic acid0low20
saringosterol0low10
bavachin0low10
ferrous citrate0low10
hypocrellin a0low10
de-o-methyllasiodiplodin0low10
icatibant0low10
jaw0medium332
adenanthin0low10
ankaflavin0low20
aegeline0low10
aflatoxin m10medium11
alisol a0low10
hericenone c0low10
cyanidin-3-o-beta-glucopyranoside0low90
homopropargylglycine0low10
nad0medium1056
mdv 31000low10
tin mesoporphyrin0low20
CDN11630low10
protectin d10low30
cytochrome c-t0low180
17,18-epoxy-5,8,11,14-eicosatetraenoic acid0low10
amarouciaxanthin a0low10
diphlorethohydroxycarmalol0low10
bms 3094030low10
rg 71280low10
calcitonin0low50
cosyntropin0medium161
cholecystokinin0medium26836
ceruletide0medium151
motilin0low120
dynorphins0low160
bivalirudin0low20
atrial natriuretic factor0medium829
thymalfasin0low10
ganirelix0low30
adrenocorticotropin zinc0medium11
xenin 250low40
hes1 protein, human0low10
glycoprotein e2, hepatitis c virus0medium11
thrombin receptor peptide (42-55)0low10
vitisin a0low10
humanin0low20
nociceptin0low30
pyx 20low10
glucagon-like peptide 1 (7-36)amide0medium244
gastrins0medium684
avoparcin0low10
beta-endorphin0medium12411
thymosin beta(4)0low20
neuropeptide y0medium64116
pancreastatin0low60
pancreastatin-520low10
iberiotoxin0low30
angiotensinogen0medium803
corticotropin-like intermediate lobe peptide0low20
ac 1870low10
alpha-msh0low10
bq 30200low10
cortistatin 140low30
irl 16200low10
glucagon-like peptide 1 (7-36)0medium62
tannins0medium172
oligonucleotides0medium161
glucagon-like peptide 10medium1,166181
acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ilys-prolyl-alaninamide0low20
insulin glulisine0medium53
insulin detemir0medium105
th95070medium32
incretins0medium26336
msh, 4-nle-7-phe-alpha-0low120
c-peptide0medium704133
gastrin 170low10
natriuretic peptide, c-type0low120
melanotan-10low10
exendin (9-39)0medium184
cellulose0medium6810
endothelin-10medium12911
phosphatidylcholines0medium837
atractyloside0low10
vx-7700low10
amikacin0low80
4-thiouridylic acid0low10
chlorophyll a0medium31
carbetocin0medium33
bismuth subsalicylate0low10
vendex0medium272
pevonedistat0low10
dihydroceramide0low50
nsc 237660low20
adenosine kinase0low50
hoe 333420low10
sodium salicylate0medium92
sphingosine kinase0low120
ubiquinone0medium386
pinoresinol0low10
sr 10780low20
diazepinylbenzoic acid0low30
3,4-dihydroxyphenylethanol-elenolic acid dialdehyde0medium21
calpain0low200
sapogenins0low40
ginsenoside rg20low10
cudraflavanone a0low10
menotropins0low110
chitosan0medium6914
technetium tc 99m sestamibi0medium71
umirolimus0medium11
15-deoxyprostaglandin j20low10
s-nitro-n-acetylpenicillamine0low20
optimark0low10
yil 7810low20
azd39880low10
eliglustat0low10
sodium oxybate0low40
bucladesine0low200
osteum0low20
sodium hypochlorite0low10
sodium lactate0low10
sodium nitrite0low10
raltegravir potassium0low10
amphotericin b, deoxycholate drug combination0low10
holothurin a0low10
sodium glutamate0medium2621
ro13-99040low60
sodium pertechnetate tc 99m0low30
sodium ethylxanthate0low580
cortisol succinate, sodium salt0low10
piperacillin, tazobactam drug combination0medium61
pf 9152750low20
olaparib0low10
srt17200low50
mogroside v0low10
rubusoside0low10
cx 49450low10
fps-zm10low10
phosphatidylinositol 4-phosphate0low10
s-adenosylmethionine0low160
a-9225000low10
picrotoxin0low10
canagliflozin0medium203
madecassoside0low10
ponatinib0medium11
10-nitro-oleic acid0medium21
insulin, isophane0medium155
1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetra-hydroisoquinoline0low10
arabinogalactan0low10
intrinsic factor0low40
tak-8750medium41
oxymatrine0low10
1229u910low30
albiflorin0low10
antroquinonol d0low10
sb 2901570low10
beta-lgnd20low20
mk 22060low10
suvorexant0low10
mk 82450low10
egg white0low70
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene0medium21
quetiapine fumarate0medium253
s-(1,2-dicarboxyethyl)cysteine0low20
cardiovascular agents0medium821
atb-3460low10
trelstar0medium102
cetrorelix0low20
neurotensin0medium552
deslorelin0medium21
histrelin0medium21
substance p, phe(5)-trp(7,9)-leu(11)-0low30
apelin-13 peptide0medium61
somatotropin (177-191)0low30
p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe0low10
ly25847020low10
tolterodine tartrate0low10
mannans0medium6021
pexidartinib0low20
salicortin0low10
11,12-epoxy-5,8,14-eicosatrienoic acid0low20
peptones0low10
triiodothyronine, reverse0medium436
n,n-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine0low10
2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide0low20
glycolipids0medium948
elafin0low20
piperidines0medium46945
resolvin d10low90
cyanidin 3-galactoside0low10
thymosin0low20
5-hydroxymethyl-2'-deoxyuridine0low10
7,8-dihydroxyflavanone0low10
interleukin-80medium11519
anagliptin0low30
phillyrin0low20
punicalagin0low50
d-beta-hydroxybutyrate-(r)-1,3 butanediol monoester0low10
mme0low10
pf 049717290medium11
formylchromone0low10
colistin0low20
fosinopril0medium51
5-(4-amino-1-propan-2-yl-3-pyrazolo[3,4-d]pyrimidinyl)-1,3-benzoxazol-2-amine0medium33
int-7770low50
endrin0low10
opium0low10
abemaciclib0medium21
jzl1950low10
gsk06600low10
srt30250low10
am65450low30
uridine diphosphate n-acetylgalactosamine0low30
pf-046201100low20
fructose-1,6-diphosphate0low10
gyy 41370low30
gsk525762a0low10
calcipotriene0medium31
AZD19790low10
alectinib0low10
ly29406800low10
mk 50460low10
3-methoxy-n-p-tolylquinoxalin-2-carboxamide0low20
granatin b0low10
gsk41120low20
3',5'-diiodothyronine0low10
methylcellulose0medium325
pf-47086710low10
isoquercitrin0low60
fr 2642050low10
dimethylaminomicheliolide0low10
vasoactive intestinal peptide0low250
natriuretic peptide, brain0medium17218
heme0medium123
ac31740low20
ortho evra0medium31
heparitin sulfate0low40
neuromedin b0low80
ascorbic acid0medium17430
tetracycline0medium161
chlortetracycline0low10
minocycline0low100
salicylates0medium359
dicumarol0low30
acenocoumarol0low50
phenprocoumon0low50
teriflunomide0low20
hispidin0low20
tigecycline0low40
pogostone0low10
a 7696620low10
gsk12657440low10
s 1 (combination)0low10
dolutegravir0medium21
neoagarotetraose0low10
byl7190low20
chromium tripicolinate0medium21
fluticasone propionate, salmeterol xinafoate drug combination0low10
indapamide, perindopril drug combination0medium22
betalains0low10
epidermal growth factor0low220
d-4f peptide0low10
gastrin-releasing peptide0low90
calca protein, human0medium61
kaolinite0low40
clay0low20
holothurin0low20
transforming growth factor beta0medium1726
phytoestrogens0medium517
oleuropein aglycone0low10
semaglutide0medium12628
ferrienterochelin0low10
okadaic acid0low30
sr90090low50
sr90110low20
tug-8910low10
pf-052310230medium72
resolvin D40low10
gkt1378310low10
bay 94-88620medium31
saroglitazar0low30
pyrethrins0low50
jd50370low40
globotriaosylceramide0low10
g007-lk0low10
gsk-28161260low10
ssr128129e0low10
lipoxin b40low10
maysin0low10
platycoside e0low10
bgp 150low30
thymic factor, circulating0low40
aod 96040low30
cucurbitane0low10
kiss1 protein, human0medium641
chiglitazar0low10
rome0medium323
agar0medium31
laponite0low20
davalintide0low10
resolvin d30low10
atglistatin0low10
9-PAHSA0low20
as 18428560low30
hirudin0low30
glutaminase0low30
cyclin d10low240
contraceptives, postcoital0low80
astressin b0low10
lysophosphatidylinositol0medium41
lysophosphatidylethanolamine0medium11
caseins0medium10526
ckd7320medium103
technetium tc 99m sulfur colloid0low60
teferrol0low10
sericoside0low10
gamma2-msh0low40
ap201870low10
oligomycins0low40
ellagitannin0medium31
praliciguat0medium11
g(m3) ganglioside0low70
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone0low10
s-nitroglutathione0low10
nitrophenols0low20
lewis x antigen0low20
peptide yy0medium6815
glucagon-like peptide 20medium295
calpastatin0low60
angiotensin i0low300
ascophyllum0medium21
gadoxetic acid disodium0low10
hyaluronoglucosaminidase0low60
adrenomedullin0low330
epoetin alfa0low20
angiotensin iii0low10
lithospermic acid0low10
lipofectamine0low10
harpagide0low10
diospyros0low70
nephrin0low70
carboxyatractyloside0low10
d-ala(2),mephe(4),met(0)-ol-enkephalin0low10
neferine0low10
soyasaponin ab0low10
alfaprostol0low10
daptomycin0medium41
4-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl)methoxy)phenyl)cyclopropyl)benzoic acid0low10
ls-1020low10
peoniflorin0low30
vitamin b 120medium1446
aconitine0low10
humulin s0medium244
insulin glargine0medium3318
insulin degludec0medium11
norgestrel0medium123
sermorelin0low80
s 89320low80
oxyntomodulin0medium20838
transforming growth factor alpha0low80
margatoxin0low20
insulin, 3-iodo-tyr(a14)-0low10
cyclosporine0medium525
silybin0low70
triciribine0low10
peptide yy0medium38382
lactoferrin0low170
myelin oligodendrocyte glycoprotein (35-55)0low20
digitonin0low30
protopanaxadiol0low30
catalpol0medium63
neohesperidin0low30
tomatine0low20
epilactose0low10
lutetium orthosilicate0medium11
2-hydroxyatorvastatin0low10
orabase0medium51
technetium tc 99m medronate0medium53
technetium tc-99m tetrofosmin0medium41
sodium morrhuate0low10
apyrase0low30
thromboplastin0medium322
muramidase0low90
lipofundin s0low10
rhamnogalacturonan i0low10
amyloid beta-peptides0low50
chondroitin sulfates0low90
exudates0medium23513
angiogenin0low30
bixin0low20
protopanaxatriol0low30
1-(3,4-dihydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one0low10
entecavir0low20
acyclovir0medium71
levoleucovorin0medium61
cyclic gmp0medium722
sepiapterin0low20
deoxyguanosine0medium282
guanosine diphosphate0low620
guanosine monophosphate0low20
guanosine triphosphate0low150
guanine0medium132
guanosine0low20
hypoxanthine0low40
inosinic acid0low20
inosine0low40
sapropterin0low70
folic acid0medium24921
3-methyladenine0low40
guanosine 5'-o-(3-thiotriphosphate)0low110
7,8-dihydrobiopterin0low10
pheophytin a0medium11
neopterin0medium131
rifampin0medium91
clozapine0medium9822
didanosine0low10
ganciclovir0low30
valacyclovir0low10
olanzapine0medium17252
pralidoxime0low10
zaprinast0low10
2,2'-(hydroxynitrosohydrazono)bis-ethanamine0low10
azaguanine0low10
guanylyl imidodiphosphate0low70
thiolactomycin0low10
3-benzyladenine0low10
guanosine 5'-monophosphorothioate0low10
8-hydroxyguanosine0low10
5,11-methenyltetrahydrohomofolate0low10
tegaserod0low10
norclozapine0low20
tak 4910low70
guanosine 5'-o-(2-thiodiphosphate)0low10
sildenafil citrate0medium185
ceftobiprole0low10
ceftobiprole medocaril0low10
da 81590low10
etifoxine0low10
azilsartan0low30
xav9390low10
8-bromocyclic gmp0low30
8-hydroxyguanine0low10
trypan blue0low10
8-hydroxy-2'-deoxyguanosine0medium353
clozapine n-oxide0low10
8-((4-chlorophenyl)thio)cyclic-3',5'-gmp0low10
desmethylolanzapine0low10
8-nitroguanosine 3',5'-cyclic monophosphate0low10
5-methyltetrahydrofolate0low10
fr 1676530low10
ns 3090low30
imidacloprid0low40
levomefolate calcium0medium11
cyclic guanosine monophosphate-adenosine monophosphate0low30
rvx 2080low20
amg 2210medium11
sparstolonin b0low10
lipoteichoic acid0low20
cholestyramine resin0medium334
eye0medium111
fructooligosaccharide0medium153
maltodextrin0medium136
mitotempo0low20
acetylcellulose0medium33
tauromuricholate0low20
apelin-12 peptide0medium51
carbidopa0low30
ego0low150
concanavalin a0low110
technetium tc 99m bicisate0low10
trypsinogen0low50
metallothionein0low160
vermiculite0medium11
2',7'-bis-(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester0low10
phosphorus radioisotopes0low30
4-hydroxyatorvastatin0low10
galanin-like peptide0low170
preproenkephalin0low40
d-jnki-10low10
leptin0medium7,879488
hopeaphenol0low10
pkh 260low10
pyrimidinones0low80
aluminum magnesium silicate0low10
alarin0low10
phenanthrenes0low80

Protein Targets (5,299)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Maltase-glucoamylase, intestinal018018
Prostaglandin G/H synthase 1048554
Lysosomal alpha-glucosidase016016
Glucose-6-phosphate 1-dehydrogenase0303
Sucrase-isomaltase, intestinal013013
Mu-type opioid receptor08624125
Delta-type opioid receptor06719102
Kappa-type opioid receptor07416107
6-phosphogluconate dehydrogenase, decarboxylating0707
Beta-secretase 1037139
Probable maltase-glucoamylase 20707
Sialidase-2016016
Cytochrome P450 2C9 01448158
IDH117700177
chromobox protein homolog 139200392
geminin57200572
POU domain, class 2, transcription factor 101013
Spike glycoprotein271824303
Chain A, TYROSYL-DNA PHOSPHODIESTERASE22600226
phosphopantetheinyl transferase23400234
TDP1 protein68600686
euchromatic histone-lysine N-methyltransferase 258900589
survival motor neuron protein isoform d22200222
5-hydroxytryptamine receptor 3E015320
acetylcholinesterase21100211
cytochrome P450 2D633500335
v-jun sarcoma virus 17 oncogene homolog (avian)26900269
cytochrome P450 2D6 isoform 117000170
cellular tumor antigen p53 isoform a14600146
cytochrome P450 2C19 precursor17000170
cytochrome P450 2C9 precursor16500165
thyroid hormone receptor beta isoform a19800198
thyroid hormone receptor beta isoform 250600506
huntingtin isoform 2710071
peripheral myelin protein 2224900249
cytochrome P450 3A4 isoform 134400344
muscarinic acetylcholine receptor M116400164
Gamma-aminobutyric acid receptor subunit pi3444611401
Polyunsaturated fatty acid lipoxygenase ALOX15B13180139
ATP-binding cassette sub-family C member 303360336
Multidrug resistance-associated protein 403420349
5-hydroxytryptamine receptor 3B016422
Bile salt export pump05010505
Beta-1 adrenergic receptor0512475
5-hydroxytryptamine receptor 1A0592687
5-hydroxytryptamine receptor 2C0671181
D(2) dopamine receptor012712151
5-hydroxytryptamine receptor 2A08515101
Gamma-aminobutyric acid receptor subunit beta-13444611401
Alpha-1B adrenergic receptor014516161
Gamma-aminobutyric acid receptor subunit delta3444611401
Gamma-aminobutyric acid receptor subunit gamma-23444713404
D050055
5-hydroxytryptamine receptor 1A014217167
Gamma-aminobutyric acid receptor subunit alpha-53444711402
Gamma-aminobutyric acid receptor subunit alpha-33444611401
Gamma-aminobutyric acid receptor subunit gamma-13444711402
Gamma-aminobutyric acid receptor subunit alpha-23444613403
Alpha-1D adrenergic receptor0801698
5-hydroxytryptamine receptor 2A014613169
5-hydroxytryptamine receptor 2C015112166
Gamma-aminobutyric acid receptor subunit alpha-43444611401
Gamma-aminobutyric acid receptor subunit gamma-33444611401
5-hydroxytryptamine receptor 1B01037111
5-hydroxytryptamine receptor 1D029839
Gamma-aminobutyric acid receptor subunit alpha-63444611401
5-hydroxytryptamine receptor 1F028736
5-hydroxytryptamine receptor 5A0202
5-hydroxytryptamine receptor 2B0601171
Sodium-dependent serotonin transporter015313167
5-hydroxytryptamine receptor 7 029837
5-hydroxytryptamine receptor 7042246
Alpha-1B adrenergic receptor0351562
Glutamate receptor ionotropic, NMDA 1 2481071
5-hydroxytryptamine receptor 2B01619174
Alpha-1A adrenergic receptor015818176
5-hydroxytryptamine receptor 3A025634
Histamine H2 receptor246103272
5-hydroxytryptamine receptor 60971105
Beta-2 adrenergic receptor0415
D(2) dopamine receptor08811105
Gamma-aminobutyric acid receptor subunit alpha-13444913406
Gamma-aminobutyric acid receptor subunit beta-33444711402
Gamma-aminobutyric acid receptor subunit beta-23444613403
Glutamate receptor ionotropic, NMDA 2A 145865
Glutamate receptor ionotropic, NMDA 2B148969
Glutamate receptor ionotropic, NMDA 2C146867
Glutamate receptor ionotropic, NMDA 2D143863
5-hydroxytryptamine receptor 3D015320
Glutamate receptor ionotropic, NMDA 3B143863
5-hydroxytryptamine receptor 3C015320
GABA theta subunit3444611401
Canalicular multispecific organic anion transporter 103230325
Gamma-aminobutyric acid receptor subunit epsilon3444611401
Glutamate receptor ionotropic, NMDA 3A143863
aldehyde dehydrogenase 1 family, member A143200432
histone acetyltransferase KAT2A isoform 122100221
5-hydroxytryptamine receptor 1D017126
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE33300333
thioredoxin reductase34800348
ATAD5 protein, partial25200252
GLS protein27100271
regulator of G-protein signaling 425100251
67.9K protein17700177
Parkin810081
bromodomain adjacent to zinc finger domain 2B14000140
nuclear factor erythroid 2-related factor 2 isoform 215600157
ras-related protein Rab-9A10500105
serine/threonine-protein kinase mTOR isoform 110300103
urokinase-type plasminogen activator precursor11600116
plasminogen precursor11600116
urokinase plasminogen activator surface receptor precursor11600116
D(1A) dopamine receptor594063
Ataxin-227000270
ATP-dependent phosphofructokinase24100241
Chain A, HADH2 protein22000220
Chain B, HADH2 protein22000220
Chain A, Ferritin light chain18100181
Chain A, Cruzipain12400124
USP1 protein, partial32000320
Microtubule-associated protein tau32100322
glucocorticoid receptor [Homo sapiens]49800498
peroxisome proliferator-activated receptor delta35000350
peroxisome proliferator activated receptor gamma37500375
vitamin D (1,25- dihydroxyvitamin D3) receptor33300333
arylsulfatase A20900209
Bloom syndrome protein isoform 119600196
vitamin D3 receptor isoform VDRA25200252
DNA polymerase beta930093
nuclear factor erythroid 2-related factor 2 isoform 151300513
peptidyl-prolyl cis-trans isomerase NIMA-interacting 111300113
M-phase phosphoprotein 812100121
Alpha-synuclein7124196
Peroxisome proliferator-activated receptor alpha223544104
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A15700157
Chain A, RNA-directed RNA polymerase NS50505
acid sphingomyelinase350035
importin subunit beta-1 isoform 1840084
flap endonuclease 115800158
serine/threonine-protein kinase PLK1580058
snurportin-1840084
GTP-binding nuclear protein Ran isoform 1460046
DNA polymerase eta isoform 1730073
DNA polymerase iota isoform a (long)22300223
DNA polymerase kappa isoform 120300203
fibroblast growth factor 22 isoform 1 precursor0004
Mitogen-activated protein kinase 13061622
Beta-lactamase013013
Transthyretin0151737
Fatty acid-binding protein, intestinal012517
Fatty acid-binding protein, adipocyte010616
Cyclin-A2018120
Cannabinoid receptor 1032739
Cyclin-dependent kinase 20314074
Choline O-acetyltransferase0303
Mitogen-activated protein kinase 12061925
Guanine nucleotide-binding protein G700070
Fatty acid-binding protein 50729
Fatty acid-binding protein 50033
Mitogen-activated protein kinase 11063440
Mitogen-activated protein kinase 140483886
farnesoid X nuclear receptor32500325
estrogen nuclear receptor alpha78400784
Voltage-dependent calcium channel gamma-2 subunit27000270
Cellular tumor antigen p5345510456
Glutamate receptor 2286157314
Choline O-acetyltransferase 0507
glucocerebrosidase10600106
Alpha-mannosidase0516
alpha-galactosidase640064
Trehalase 0303
lysosomal alpha-glucosidase preproprotein730073
Trehalase0101
Trehalase 0202
Lysosomal acid glucosylceramidase0718
Alpha-galactosidase A0202
Alpha-glucosidase MAL620404
Lactase-phlorizin hydrolase0606
Beta-glucosidase A0202
Sucrase-isomaltase, intestinal014014
Beta-glucosidase0101
Protein-lysine 6-oxidase0606
Alpha-mannosidase 20202
Glycogen debranching enzyme0606
Glycogen debranching enzyme0404
Alpha-glucosidase MAL320505
Oligo-1,6-glucosidase IMA10707
Alpha-glucosidase MAL12010010
Oxysterols receptor LXR-beta08919
Alpha-amylase 0101
Trehalose synthase/amylase TreS0101
Lactase-phlorizin hydrolase 0303
Oxysterols receptor LXR-alpha0101123
Neutral alpha-glucosidase AB0202
Ceramide glucosyltransferase0606
Lysosomal acid glucosylceramidase0202
Beta-glucosidase 0101
Lysosomal alpha-glucosidase011011
Cytosolic beta-glucosidase0101
Non-lysosomal glucosylceramidase0505
Putative alpha-glucosidase0303
Platelet-activating factor receptor45010
Inositol monophosphatase 111100111
Neuraminidase 035137
L-lactate dehydrogenase A chain08311
Neuraminidase0404
L-lactate dehydrogenase A chain0112
L-lactate dehydrogenase B chain0303
Tyrosine-protein phosphatase non-receptor type 1070376
Tyrosinase028028
Amine oxidase [flavin-containing] A079184
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, Phosphodiesterase 9A0101
Chain A, Class I phosphodiesterase PDEB10101
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera0101
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
glp-1 receptor, partial17400174
thyroid stimulating hormone receptor28300283
estrogen-related nuclear receptor alpha62200622
Phosphodiesterase 0707
mitogen-activated protein kinase 120200202
cGMP-dependent 3',5'-cyclic phosphodiesterase015015
Monocarboxylate transporter 40208
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0909
cGMP-specific 3',5'-cyclic phosphodiesterase029131
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0404
Renin013215
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 010010
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0708
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0708
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0709
Adenosine receptor A1249568
Adenosine receptor A3016017
Adenosine receptor A2a0481572
Adenosine receptor A2b015630
Adenosine receptor A2b018330
Adenosine receptor A10421364
Adenosine receptor A2a045972
Sodium-dependent serotonin transporter055662
Adenosine receptor A2a0505
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0415
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0708
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A012013
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B010010
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B013014
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0606
cAMP-specific 3',5'-cyclic phosphodiesterase 4B022126
cAMP-specific 3',5'-cyclic phosphodiesterase 4D026128
cGMP-inhibited 3',5'-cyclic phosphodiesterase B020021
Voltage-dependent L-type calcium channel subunit alpha-1C064166
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0606
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C015016
cGMP-inhibited 3',5'-cyclic phosphodiesterase A021022
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0606
Phosphodiesterase 0101
Phosphodiesterase 0606
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0505
Dihydropteridine reductase0101
Amine oxidase [flavin-containing] B070274
Amine oxidase [flavin-containing] B08010
Large neutral amino acids transporter small subunit 1012013
Chain A, Beta-lactamase18300183
Thyroid hormone receptor beta0707
Xanthine dehydrogenase/oxidase043044
Diacylglycerol kinase alpha0202
RAR-related orphan receptor gamma49600496
GLI family zinc finger 351900519
AR protein66700667
estrogen receptor 2 (ER beta)33900339
nuclear receptor subfamily 1, group I, member 342000420
progesterone receptor35800358
retinoic acid nuclear receptor alpha variant 150500505
pregnane X nuclear receptor48100481
aryl hydrocarbon receptor27000270
thyroid stimulating hormone receptor23300233
activating transcription factor 622100221
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a22800228
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 119500195
Kelch-like ECH-associated protein 10156
Histone acetyltransferase KAT80305
hypoxia-inducible factor 1 alpha subunit18100181
caspase 7, apoptosis-related cysteine protease11400114
retinoid X nuclear receptor alpha44800448
caspase-311400114
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a36500365
heat shock protein beta-121200212
Estrogen receptor1702196
Estrogen receptor beta1371756
nonstructural protein 1970097
Glucose transporter0505
Cdk-related protein kinase 60202
Protein kinase domain-containing protein0202
Hexose transporter 1 0505
Solute carrier family 2, facilitated glucose transporter member 109110
Calcium-dependent protein kinase 1021517
Mitogen-activated protein kinase 0202
Proline--tRNA ligase0202
Calcium-dependent protein kinase 40303
Lysine--tRNA ligase 0202
Cannabinoid receptor 10481371
Cannabinoid receptor 2 0401160
Cannabinoid receptor 208311
Gamma-aminobutyric acid receptor subunit alpha-109214
Gamma-aminobutyric acid receptor subunit beta-109214
Gamma-aminobutyric acid receptor subunit alpha-208213
Gamma-aminobutyric acid receptor subunit alpha-308213
Gamma-aminobutyric acid receptor subunit alpha-408213
Gamma-aminobutyric acid receptor subunit gamma-208213
Genome polyprotein 0415
Prothrombin 0808
Coagulation factor X018018
Genome polyprotein0202
Replicase polyprotein 1ab0572784
Replicase polyprotein 1ab09033123
Alpha-amylase 1A 0909
5'-nucleotidase0506
Squalene monooxygenase 0607
Ectonucleoside triphosphate diphosphohydrolase 10303
Anthrax toxin receptor 20707
Xanthine dehydrogenase/oxidase033138
Neuraminidase 0101
5'-nucleotidase0404
Histone H2A.x20600206
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)15100151
peripheral myelin protein 22 isoform 112900129
nuclear receptor ROR-gamma isoform 126900269
lamin isoform A-delta1046500465
Adenosine receptor A30967106
Adenosine receptor A10808
Vasopressin V2 receptor0104
Adenosine receptor A106311
Adenylate cyclase type 50506
Adenylate cyclase type 10216
Sigma non-opioid intracellular receptor 1025429
corticotropin-releasing hormone receptor 20224
corticotropin releasing factor-binding protein0224
apical membrane antigen 1, AMA1710071
lethal factor (plasmid)18602188
botulinum neurotoxin type A0022
botulinum neurotoxin type F, BoNT/F0022
Sodium/glucose cotransporter 1011617
Sodium/glucose cotransporter 2011617
endonuclease IV900090
Peroxisome proliferator-activated receptor gamma04763115
Chain A, Retinaldehyde-binding protein 10011
Chain A, Retinaldehyde-binding protein 10011
Prostaglandin E synthase013013
Polyunsaturated fatty acid 5-lipoxygenase059161
Tyrosine-protein phosphatase non-receptor type 2019019
Prostaglandin G/H synthase 207718100
Prolyl endopeptidase012012
Neuropeptide Y receptor type 40202
Chain A, ATP-DEPENDENT DNA HELICASE Q110100101
prostaglandin E2 receptor EP2 subtype3007
Transient receptor potential cation channel subfamily A member 1042534
SMAD family member 220200202
Fumarate hydratase16700167
SMAD family member 320200202
Smad315900159
cytochrome P450 family 3 subfamily A polypeptide 444500445
G32400324
polyprotein16700167
Caspase-7630063
parathyroid hormone/parathyroid hormone-related peptide receptor precursor990099
caspase-3630063
replicative DNA helicase0007
recombinase A0077
neuropeptide S receptor isoform A860086
Interferon beta43800438
HLA class I histocompatibility antigen, B alpha chain 32400324
Inositol hexakisphosphate kinase 132400324
cytochrome P450 2C9, partial32400324
Lysine-specific demethylase 6B0202
Lysine-specific demethylase 4B0101
Heat shock protein HSP 90-alpha081019
Heat shock protein HSP 90-beta08616
Cholesteryl ester transfer protein0516
Lysine-specific demethylase 5A0404
Endoplasmin0123
Hypoxia-inducible factor 1-alpha014217
Endothelial PAS domain-containing protein 108110
Lysine-specific demethylase 4C0606
Sex hormone-binding globulin023032
pregnane X receptor810081
nuclear receptor subfamily 1, group I, member 2770077
Glucocorticoid receptor1651098
Glycine receptor subunit alpha-1052052
Corticosteroid-binding globulin018019
Androgen receptor01161119
Glycine receptor subunit beta052052
Glycine receptor subunit alpha-2052052
Glycine receptor subunit alpha-3052052
Mitogen-activated protein kinase 3 093444
Sodium-dependent dopamine transporter 01228131
TAR DNA-binding protein 4314210143
Cytochrome P450 4F20303
Endothelin receptor type B015116
Endothelin-1 receptor018120
Phenylethanolamine N-methyltransferase011013
Sodium-dependent noradrenaline transporter 016221184
Sodium-dependent dopamine transporter055661
Transporter036138
PPM1D protein13800138
EWS/FLI fusion protein33800339
Inhibitor of nuclear factor kappa-B kinase subunit beta0141530
Tyrosine-protein kinase JAK2082131
Cytochrome P450 3A4016514191
Interferon-induced, double-stranded RNA-activated protein kinase051722
Carbonic anhydrase 12071292
Carbonic anhydrase 101482183
Carbonic anhydrase 201638204
Plasma kallikrein06217
Carbonic anhydrase 3041253
Carbonic anhydrase 40912111
Carbonic anhydrase 6057276
Histamine H1 receptor017219
Carbonic anhydrase 5A, mitochondrial062487
Histamine H1 receptor078891
Carbonic anhydrase030037
Carbonic anhydrase 7066285
Carbonic anhydrase08016
Carbonic anhydrase 90803104
Carbonic anhydrase 010018
Carbonic anhydrase-like protein, putative00011
Carbonic anhydrase08017
Carbonic anhydrase013022
Carbonic anhydrase 07015
Carbonic anhydrase 15036044
Carbonic anhydrase 13036051
Histamine H4 receptor018829
Carbonic anhydrase 14045265
Carbonic anhydrase 5B, mitochondrial046269
dopamine D1 receptor450045
Mu-type opioid receptor042954
Chain A, Serine/threonine-protein Kinase 12-a0101
Aurora kinase A0113546
Dual specificity mitogen-activated protein kinase kinase 10101
Dual specificity protein kinase TTK032932
Serine/threonine-protein kinase PLK10162541
Aurora kinase B0263460
Aurora kinase C021820
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, 2-oxoglutarate Oxygenase24100241
Chain A, Methyltransferase Wbdd0101
15-lipoxygenase, partial15000150
NFKB1 protein, partial10700107
Thrombopoietin880088
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0111729
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha0202
Serine/threonine-protein kinase PLK4073542
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta021517
Bromodomain-containing protein 406410
5-hydroxytryptamine receptor 401138121
Integrin beta-310582115
Cytochrome P450 1A20996112
Integrin alpha-IIb10561112
Neuronal acetylcholine receptor subunit alpha-42324553
Serine/threonine-protein kinase pim-10183657
Neuronal acetylcholine receptor subunit beta-22322551
Casein kinase II subunit alpha'0263561
Proteinase-activated receptor 10528
Bromodomain-containing protein 20628
Phosphatidylinositol 3-kinase regulatory subunit alpha0506
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Type-1 angiotensin II receptor09211
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0161936
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0101729
Serine/threonine-protein kinase mTOR0172037
Serine/threonine-protein kinase mTOR0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0141732
Glycogen synthase kinase-3 beta0323870
Casein kinase II subunit beta026127
Casein kinase II subunit alpha0291948
DNA-dependent protein kinase catalytic subunit016016
Serine-protein kinase ATM0505
Serine/threonine-protein kinase ATR051015
Bromodomain-containing protein 30426
Serine/threonine-protein kinase pim-3031720
Phosphoinositide 3-kinase regulatory subunit 50202
Serine/threonine-protein kinase PLK30101727
Serine/threonine-protein kinase PLK2081523
Luciferase25300253
histone deacetylase 9 isoform 3750075
Aldo-keto reductase family 1 member B101410141
Alpha-2A adrenergic receptor014814170
ATPase family AAA domain-containing protein 517900179
Chain A, Tryptase beta-20101
Chain A, Tryptase beta-20101
Chain A, Tryptase beta-20101
Chain A, Trypsin0101
Chain A, Tryptase beta-20101
eyes absent homolog 2 isoform a220022
Membrane primary amine oxidase 0505
Urokinase-type plasminogen activator013013
Cationic trypsin013013
Tryptase beta-20101
Transcriptional activator protein LasR0303
7,8-dihydro-8-oxoguanine triphosphatase0415
Regulatory protein RhlR0304
Glutaminyl-peptide cyclotransferase0909
Membrane primary amine oxidase0305
Pteridine reductase, putative 0101
Proton-coupled amino acid transporter 1021022
Phosphatidylinositol 4-kinase alpha010011
Phosphatidylinositol 4-kinase type 2-beta09010
Phosphatidylinositol 4-kinase type 2-alpha010011
Phosphatidylinositol 4-kinase beta0101526
Peroxisome proliferator-activated receptor delta0172547
Palmitoyltransferase ZDHHC20101
Ghrelin O-acyltransferase0202
Ghrelin O-acyltransferase0707
Proteinase-activated receptor 20112
Chain A, Putative fructose-1,6-bisphosphate aldolase12400124
Hsf1 protein001115
thioredoxin glutathione reductase810081
hypothetical protein, conserved380038
pyruvate kinase320032
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0707
glucose-6-phosphate 1-dehydrogenase isoform b0707
fructose-bisphosphate aldolase A5005
pyruvate kinase PKM isoform a130013
DNA dC->dU-editing enzyme APOBEC-3G isoform 1289037
Endothelin receptor type B911121
Endothelin-1 receptor910221
Disabled homolog 2-interacting protein0101
Adenylate cyclase type 100101
hypothetical protein CAALFM_CR05890CA0005
H3 histone acetyltransferase0005
large T antigen024125
Peptidyl-prolyl cis-trans isomerase FKBP50224
Monocarboxylate transporter 10308
Monocarboxylate transporter 20808
interferon gamma precursor00013
atrial natriuretic peptide receptor 2 precursor580058
Tubulin alpha-1A chain0539
Tubulin beta chain0538
Cytochrome P450 1A1042346
Cytochrome P450 1B1050254
Tubulin beta-2B chain07110
Similar to alpha-tubulin isoform 1 0619
Similar to alpha-tubulin isoform 1 0608
Nrf2270027
BRCA1300030
tumor susceptibility gene 101 protein140014
5-hydroxytryptamine receptor 3A0808
5-hydroxytryptamine receptor 1E0405
5-hydroxytryptamine receptor 3A024832
5-hydroxytryptamine receptor 5A012013
5-hydroxytryptamine receptor 3B0606
5-hydroxytryptamine receptor 3B024832
DNA repair and recombination protein RadA0022
Cytochrome P450 2A6023428
Sulfotransferase 1A1 0006
Cytochrome P450 2A50607
Sulfotransferase 1E10001
Sulfotransferase 1A10316
Sulfotransferase 2A10102
ClpP230023
Neutrophil cytosol factor 10404
Nuclear receptor ROR-gamma12576138
Fatty acid-binding protein, liver0909
Olfactory receptor 51E201910
interleukin 8800080
potassium voltage-gated channel subfamily H member 2 isoform d21800218
Nuclear receptor subfamily 1 group I member 2062936
Nuclear factor erythroid 2-related factor 201916
Carnitine O-palmitoyltransferase 1, liver isoform 0303
Carnitine palmitoyl transferase I liver isoform 0202
chaperonin-containing TCP-1 beta subunit homolog8008
Cytochrome P450 2C8026230
Cytochrome P450 2D601127125
Cytochrome P450 2B6024229
Cytochrome P450 3A5011114
Cytochrome P450 2C19084391
Solute carrier family 22 member 6027040
Solute carrier family 22 member 8021034
runt-related transcription factor 1 isoform AML1b120012
core-binding factor subunit beta isoform 2120012
C-C chemokine receptor type 10213
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0214
Protein farnesyltransferase subunit beta0214
C-C chemokine receptor type 506411
C-C chemokine receptor type 80011
Methionine aminopeptidase 10112
Deoxyhypusine hydroxylase0202
Transmembrane prolyl 4-hydroxylase0257
P53230023
lethal(3)malignant brain tumor-like protein 1 isoform I380038
Rap guanine nucleotide exchange factor 4631064
Metabotropic glutamate receptor 60337
Glutamate receptor 11815746
Glutamate receptor 31815746
Glutamate receptor 41815746
Glutamate receptor ionotropic, kainate 1113319
Glutamate receptor ionotropic, kainate 10729
Glutamate receptor ionotropic, kainate 2112318
Glutamate receptor 1010314
Glutamate receptor 2010314
Glutamate receptor 308210
Glutamate receptor ionotropic, kainate 3114017
Glutamate receptor 4010112
Glutamate receptor ionotropic, kainate 4111014
Glutamate receptor ionotropic, kainate 20729
Glutamate receptor ionotropic, kainate 30606
Glutamate receptor ionotropic, kainate 5111115
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial0101
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial0101
Glycogen synthase kinase-3 alpha0193453
Hepatocyte growth factor receptor0133346
nuclear factor NF-kappa-B p105 subunit isoform 1360238
Cytochrome P450 1A10136
Aryl hydrocarbon receptor01810
Neuronal proto-oncogene tyrosine-protein kinase Src 0203
Solute carrier family 28 member 30909
72 kDa type IV collagenase026027
Matrilysin011011
Aminopeptidase N0404
Prolyl 4-hydroxylase subunit alpha-1013013
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60606
Alpha-(1,3)-fucosyltransferase 70606
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10606
Polyphenol oxidase 2055167
ATP-dependent translocase ABCB1010915158
Sterol O-acyltransferase 10808
17-beta-hydroxysteroid dehydrogenase type 109010
Corticosteroid 11-beta-dehydrogenase isozyme 1012214
17-beta-hydroxysteroid dehydrogenase type 2013013
Corticosteroid 11-beta-dehydrogenase isozyme 10819
Corticosteroid 11-beta-dehydrogenase isozyme 20101
Corticosteroid 11-beta-dehydrogenase isozyme 20617
Gamma-butyrobetaine dioxygenase0426
polyunsaturated fatty acid lipoxygenase ALOX12430043
NPC intracellular cholesterol transporter 1 precursor830083
FAD-linked sulfhydryl oxidase ALR0008
Guanylate cyclase soluble subunit beta-20003
Guanylate cyclase soluble subunit alpha-20003
Guanylate cyclase soluble subunit alpha-10014
Guanylate cyclase soluble subunit beta-10014
Histone acetyltransferase p3000719
CREB-binding protein45211
Low molecular weight phosphotyrosine protein phosphatase0505
Solute carrier family 22 member 8015022
Transient receptor potential cation channel subfamily V member 109615
Glycogen phosphorylase, muscle form015015
Indoleamine 2,3-dioxygenase 1020122
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE0303
Chain A, Protocatechuate 3,4-dioxygenase0303
Chain M, Protocatechuate 3,4-dioxygenase0303
Vitamin D3 receptor0121330
Carbonic anhydrase011011
Hydroxycarboxylic acid receptor 20347
Hydroxycarboxylic acid receptor 10011
pyruvate kinase PKM isoform b240024
Ornithine decarboxylase243028
4-aminobutyrate aminotransferase, mitochondrial0214
Protein skinhead-10202
Solute carrier family 22 member 20019019
Solute carrier family 22 member 6019020
Calmodulin-1010212
Androgen receptor1441175
Pyruvate kinase PKM013417
Polyunsaturated fatty acid lipoxygenase ALOX15013013
Polyunsaturated fatty acid lipoxygenase ALOX120909
Fatty acid synthase021021
Dipeptidyl peptidase 3011011
HSP40, subfamily A [Plasmodium falciparum 3D7]00010
Kynureninase0001
D(4) dopamine receptor054466
D(3) dopamine receptor01327148
Trace amine-associated receptor 10044
Trace amine-associated receptor 10066
Trace amine-associated receptor 10167
Sigma non-opioid intracellular receptor 1018826
5-hydroxytryptamine receptor 3A0336
Chain A, DNA-3-methyladenine glycosylase I0011
Chain A, DNA-3-METHYLADENINE GLYCOSYLASE I0011
Chain A, Dna-3-methyladenine Glycosylase I0011
Tyrosine-protein kinase Lck0303869
Tyrosine-protein kinase Fyn0383674
Acetylcholinesterase079383
Pancreatic triacylglycerol lipase029031
Mitogen-activated protein kinase 100233659
Aldo-keto reductase family 1 member B10505
Inositol polyphosphate multikinase0909
Enoyl-acyl-carrier protein reductase 020020
3-oxoacyl-acyl-carrier protein reductase 012012
Inositol hexakisphosphate kinase 20909
thyrotropin-releasing hormone receptor460046
hemoglobin subunit beta190019
Delta-aminolevulinic acid dehydratase0303
Isocitrate lyase 10202
Isocitrate lyase0202
Isocitrate lyase0101
Glycoprotein hormones alpha chain150015
Tubulin--tyrosine ligase0202
Regulatory protein E20022
Aldo-keto reductase family 1 member C3016016
Chain A, Aspartate Aminotransferase0011
Chain B, Aspartate Aminotransferase0011
Chain A, Aspartate Aminotransferase0011
Chain B, Aspartate Aminotransferase0011
Chain A, Aspartate aminotransferase0011
Chain B, Aspartate aminotransferase0011
Chain A, Aspartate aminotransferase0011
Chain A, Aspartate aminotransferase0011
Chain A, Aspartate aminotransferase0011
Chain B, Aspartate aminotransferase0011
C-terminal-binding protein 20303
DNA topoisomerase type IB small subunit0011
DNA topoisomerase I 0011
Aryl hydrocarbon receptor0123
G-protein coupled receptor 840011
G-protein coupled receptor 8406714
Proliferating cell nuclear antigen0505
Calcium dependent protein kinase0101
luciferase8008
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)790079
Replicase polyprotein 1ab0242448
D(1A) dopamine receptor13400134
atrial natriuretic peptide receptor 1 precursor450045
dual specificity tyrosine-phosphorylation-regulated kinase 1A00011
glycogen synthase kinase-3 alpha00011
muscleblind-like protein 1 isoform 1940094
serine/threonine-protein kinase 33 isoform a0089
endoribonuclease toxin MazF0044
Arginase-10112
Dipeptidyl peptidase 40404
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10808
Tyrosine-protein kinase SYK0104151
Lactoylglutathione lyase019019
Myosin light chain kinase, smooth muscle083442
Arginase-10505
phosphoglycerate kinase210021
Tubulin beta-4A chain09719
Tubulin beta chain09719
Tubulin alpha-3C chain09719
Tubulin alpha-1B chain09719
Tubulin alpha-4A chain09719
Tubulin beta-4B chain09719
Tubulin beta-3 chain010720
Tubulin beta-2A chain09719
Tubulin beta-8 chain09719
Tubulin alpha-3E chain09719
Tubulin alpha-1A chain09719
Tubulin alpha-1C chain09719
Tubulin beta-6 chain09719
Tubulin beta-2B chain09719
Tubulin beta-1 chain09719
Broad substrate specificity ATP-binding cassette transporter ABCG2072582
Thyroid hormone receptor alpha010818
Thyroid hormone receptor beta010818
Retinoic acid receptor RXR-alpha0121935
Sodium/bile acid cotransporter014116
Solute carrier organic anion transporter family member 1C10606
Prostaglandin G/H synthase 1069070
Chain A, Penicillin Amidohydrolase0303
Chain B, Penicillin Amidohydrolase0303
Chain A, Penicillin Amidohydrolase0303
Chain B, Penicillin Amidohydrolase0303
Chain A, Penicillin Amidohydrolase0303
Chain B, Penicillin Amidohydrolase0303
Chain A, Penicillin Amidohydrolase0303
Chain B, Penicillin Amidohydrolase0303
Chain A, Penicillin Amidohydrolase0303
Chain B, Penicillin Amidohydrolase0303
Chain A, Penicillin Amidohydrolase0303
Chain B, Penicillin Amidohydrolase0303
Chain A, Penicillin Amidohydrolase0303
Chain B, Penicillin Amidohydrolase0303
Chain A, Protocatechuate 3,4-dioxygenase0011
Chain M, Protocatechuate 3,4-dioxygenase0011
Olfactory receptor class A-like protein 10033
RGS12130013
alkaline phosphatase, intestinal0437
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0617
intestinal alkaline phosphatase precursor0617
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1120012
alkaline phosphatase, germ cell type preproprotein0437
POsterior Segregation001212
Zinc finger protein mex-5001111
5-hydroxytryptamine receptor 6012719
5-hydroxytryptamine receptor 5A011718
5-hydroxytryptamine receptor 5B011718
5-hydroxytryptamine receptor 4 013721
Aryl hydrocarbon receptor0202
Tyrosine-protein kinase ABL10263970
Breakpoint cluster region protein0123350
Ribosyldihydronicotinamide dehydrogenase [quinone]0143145
Protein kinase C alpha type0223358
Transient receptor potential cation channel subfamily A member 10101222
Transient receptor potential cation channel subfamily V member 10111431
Chain A, Macrophage migration inhibitory factor0101
Chain C, Macrophage migration inhibitory factor0101
Tyrosinase012012
Macrophage migration inhibitory factor024125
Death-associated protein kinase 10141731
Bile acid receptor0141732
transcriptional regulator ERG isoform 3460046
Tumor necrosis factor0538
cAMP-specific 3',5'-cyclic phosphodiesterase 4A022225
cGMP-dependent 3',5'-cyclic phosphodiesterase0505
cAMP-specific 3',5'-cyclic phosphodiesterase 4C015015
cGMP-specific 3',5'-cyclic phosphodiesterase0505
Chain A, TGF-beta receptor type-10101
tyrosine-protein kinase Yes370037
Serine/threonine-protein kinase 25001717
Citron Rho-interacting kinase013435
Serine/threonine-protein kinase RIO3001717
Serine/threonine-protein kinase Chk1033538
Cyclin-G-associated kinase033538
Serine/threonine-protein kinase DCLK1001717
Muscle, skeletal receptor tyrosine-protein kinase001717
3-phosphoinositide-dependent protein kinase 1071825
Death-associated protein kinase 3021820
Receptor-interacting serine/threonine-protein kinase 2053439
NUAK family SNF1-like kinase 1041721
Ribosomal protein S6 kinase alpha-5043539
Ribosomal protein S6 kinase alpha-4003434
Serine/threonine-protein kinase 16003535
Serine/threonine-protein kinase PAK 3001717
Serine/threonine-protein kinase 17B031720
Serine/threonine-protein kinase 10003434
Serine/threonine-protein kinase D3083544
Cyclin-dependent kinase 14011719
Mitogen-activated protein kinase kinase kinase kinase 4003434
Serine/threonine-protein kinase LATS1003434
Serine/threonine-protein kinase PAK 4033437
Epidermal growth factor receptor06735102
RAF proto-oncogene serine/threonine-protein kinase0101727
Receptor tyrosine-protein kinase erbB-20241741
High affinity nerve growth factor receptor023335
Insulin receptor093545
Tyrosine-protein kinase Fes/Fps003434
Macrophage colony-stimulating factor 1 receptor091726
Tyrosine-protein kinase Yes083442
Tyrosine-protein kinase Lyn053439
Proto-oncogene tyrosine-protein kinase receptor Ret0123446
Insulin-like growth factor 1 receptor083442
Tyrosine-protein kinase HCK073441
Proto-oncogene tyrosine-protein kinase ROS021719
Platelet-derived growth factor receptor beta0173452
Tyrosine-protein kinase Fgr002323
Mast/stem cell growth factor receptor Kit0181937
Fibroblast growth factor receptor 10113447
Myosin light chain kinase, smooth muscle021315
Proto-oncogene tyrosine-protein kinase Src0293464
Insulin receptor-related protein001717
Serine/threonine-protein kinase B-raf0113546
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform003535
Platelet-derived growth factor receptor alpha0111829
Tyrosine-protein kinase Fer003434
cAMP-dependent protein kinase catalytic subunit alpha0153449
Vascular endothelial growth factor receptor 1 0121729
Cyclin-dependent kinase 11B011719
Ephrin type-A receptor 1013233
Fibroblast growth factor receptor 2011719
Fibroblast growth factor receptor 4021720
Fibroblast growth factor receptor 3011719
cAMP-dependent protein kinase catalytic subunit beta0123446
Tyrosine-protein kinase JAK1053643
Protein kinase C eta type0112032
Activin receptor type-2A001717
MAP/microtubule affinity-regulating kinase 3003434
Mitogen-activated protein kinase 10143549
Ephrin type-A receptor 2053439
Ephrin type-A receptor 3001818
Ephrin type-A receptor 8001717
Ephrin type-B receptor 2023436
Leukocyte tyrosine kinase receptor011718
Non-receptor tyrosine-protein kinase TYK2033641
Wee1-like protein kinase003434
Tyrosine-protein kinase receptor UFO021719
Mitogen-activated protein kinase 4001717
RAC-alpha serine/threonine-protein kinase0143448
RAC-beta serine/threonine-protein kinase033437
Tyrosine-protein kinase receptor Tie-1001717
Vascular endothelial growth factor receptor 30101727
Vascular endothelial growth factor receptor 20281949
Dual specificity mitogen-activated protein kinase kinase 2043438
Receptor-type tyrosine-protein kinase FLT30343469
Bone morphogenetic protein receptor type-1A013435
Activin receptor type-1B013435
TGF-beta receptor type-1043539
Serine/threonine-protein kinase receptor R3011920
TGF-beta receptor type-2023234
Tyrosine-protein kinase CSK043438
Tyrosine-protein kinase Tec023436
Tyrosine-protein kinase TXK021719
Tyrosine-protein kinase ABL2023436
Tyrosine-protein kinase FRK013435
Tyrosine-protein kinase ZAP-70011718
Mitogen-activated protein kinase 8053742
Mitogen-activated protein kinase 9033740
Dual specificity mitogen-activated protein kinase kinase 4011920
Dual specificity mitogen-activated protein kinase kinase 3013435
Casein kinase I isoform delta073442
MAP kinase-activated protein kinase 2033437
Cyclin-dependent kinase 8041722
Casein kinase I isoform epsilon073542
Dual specificity protein kinase CLK1033336
Dual specificity protein kinase CLK2023032
Dual specificity protein kinase CLK3012728
Cyclin-dependent kinase 7093444
Cyclin-dependent kinase 90133448
Tyrosine-protein kinase Blk041721
Ribosomal protein S6 kinase alpha-3033437
Cytoplasmic tyrosine-protein kinase BMX021719
cAMP-dependent protein kinase catalytic subunit PRKX001717
Serine/threonine-protein kinase Nek2023436
Tyrosine-protein kinase JAK30121833
Dual specificity mitogen-activated protein kinase kinase 6013435
LIM domain kinase 1013435
LIM domain kinase 2013435
5'-AMP-activated protein kinase catalytic subunit alpha-2022225
Ephrin type-B receptor 3003434
Ephrin type-A receptor 5003434
Ephrin type-B receptor 4053439
Ephrin type-B receptor 1001717
Ephrin type-A receptor 4003434
Serine/threonine-protein kinase SIK1021719
Tubulin alpha-1A chain001313
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta001717
SRSF protein kinase 2001717
Casein kinase I isoform gamma-2033235
Mitogen-activated protein kinase kinase kinase 9011718
Cyclin-dependent kinase 3013133
Cyclin-dependent-like kinase 5 0163451
Cyclin-dependent kinase 16013537
Cyclin-dependent kinase 17013234
Protein kinase C epsilon type0161936
Dual specificity mitogen-activated protein kinase kinase 1083442
Angiopoietin-1 receptor081927
Mitogen-activated protein kinase kinase kinase 10011718
Protein kinase C theta type0123447
Activin receptor type-1013435
Focal adhesion kinase 1043438
Protein kinase C delta type0143651
Tyrosine-protein kinase BTK053439
Tyrosine-protein kinase receptor TYRO3001717
Cyclin-dependent kinase 18012022
Activated CDC42 kinase 1013435
Epithelial discoidin domain-containing receptor 1063440
Tyrosine-protein kinase ITK/TSK041721
Myotonin-protein kinase021719
Tyrosine-protein kinase Mer022325
Serine/threonine-protein kinase 4003535
5'-AMP-activated protein kinase catalytic subunit alpha-1023841
Serine/threonine-protein kinase PAK 1041721
Mitogen-activated protein kinase 7003434
Serine/threonine-protein kinase PAK 2003131
Serine/threonine-protein kinase 3003434
cGMP-dependent protein kinase 2001717
Non-receptor tyrosine-protein kinase TNK1003434
Receptor-interacting serine/threonine-protein kinase 1031821
Calcium/calmodulin-dependent protein kinase type II subunit beta031720
Calcium/calmodulin-dependent protein kinase type II subunit gamma013435
Calcium/calmodulin-dependent protein kinase type II subunit delta013435
Activin receptor type-2B003333
Bone morphogenetic protein receptor type-2013435
Protein-tyrosine kinase 6013435
cGMP-dependent protein kinase 1 013334
Calcium/calmodulin-dependent protein kinase type 1011819
Inhibitor of nuclear factor kappa-B kinase subunit epsilon033437
Protein-tyrosine kinase 2-beta003434
Maternal embryonic leucine zipper kinase003434
Serine/threonine-protein kinase D1081827
Ribosomal protein S6 kinase alpha-2001818
Ephrin type-A receptor 7002929
Ribosomal protein S6 kinase alpha-1043438
Dual specificity testis-specific protein kinase 1003333
Serine/threonine-protein kinase STK11003434
NT-3 growth factor receptor001717
Serine/threonine-protein kinase N1023436
Serine/threonine-protein kinase N2023436
Calcium/calmodulin-dependent protein kinase type IV003333
Mitogen-activated protein kinase kinase kinase 11013435
BDNF/NT-3 growth factors receptor001818
Mitogen-activated protein kinase 6001717
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform001717
Discoidin domain-containing receptor 2063440
AP2-associated protein kinase 1023537
Serine/threonine-protein kinase TNNI3K011718
Serine/threonine-protein kinase MRCK alpha003434
Serine/threonine-protein kinase MRCK gamma003333
Serine/threonine-protein kinase Nek5001717
Serine/threonine-protein kinase MARK2003535
Serine/threonine-protein kinase tousled-like 2001717
Serine/threonine-protein kinase 32C001717
Myosin light chain kinase family member 4001717
Calcium/calmodulin-dependent protein kinase type 1D001818
Mitogen-activated protein kinase kinase kinase kinase 3003434
MAP kinase-activated protein kinase 5043337
Serine/threonine-protein kinase BRSK2001717
Serine/threonine-protein kinase DCLK2001717
Calcium/calmodulin-dependent protein kinase kinase 1001717
Casein kinase I isoform alpha-like001717
Myosin-IIIa001717
Ankyrin repeat and protein kinase domain-containing protein 1001717
Atypical kinase COQ8A, mitochondrial003434
Mitogen-activated protein kinase 15003434
Serine/threonine-protein kinase Nek9003434
Serine/threonine-protein kinase BRSK1001717
Serine/threonine-protein kinase Nek7002424
Myosin-IIIb001717
Mitogen-activated protein kinase kinase kinase kinase 1003333
Atypical kinase COQ8B, mitochondrial001717
MAP/microtubule affinity-regulating kinase 4012930
Calcium/calmodulin-dependent protein kinase type 1G001919
Serine/threonine-protein kinase Nek1003434
Calcium/calmodulin-dependent protein kinase kinase 2023537
SRSF protein kinase 1011718
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase023436
Mitogen-activated protein kinase kinase kinase 5003434
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha001717
Serine/threonine-protein kinase RIO1001717
MAP kinase-interacting serine/threonine-protein kinase 1031720
Cyclin-dependent kinase 19021720
Testis-specific serine/threonine-protein kinase 1001717
Serine/threonine-protein kinase 33001717
Serine/threonine-protein kinase D2003434
Serine/threonine-protein kinase DCLK3001717
NUAK family SNF1-like kinase 2003333
Serine/threonine-protein kinase SIK2013435
Myosin light chain kinase 2, skeletal/cardiac muscle001717
STE20-like serine/threonine-protein kinase 003535
Tyrosine-protein kinase Srms001717
Dual specificity protein kinase CLK4012930
MAP kinase-interacting serine/threonine-protein kinase 2041822
Serine/threonine-protein kinase Nek6011718
Casein kinase I isoform gamma-1033538
Serine/threonine-protein kinase PAK 6012223
Serine/threonine-protein kinase LATS2001717
Serine/threonine-protein kinase 36011718
BMP-2-inducible protein kinase003535
Serine/threonine-protein kinase 32B001717
Mitogen-activated protein kinase kinase kinase 20003434
Serine/threonine-protein kinase MARK1001717
Serine/threonine-protein kinase pim-2022628
Serine/threonine-protein kinase PAK 5011718
Serine/threonine-protein kinase 26003434
eIF-2-alpha kinase GCN2001717
Serine/threonine-protein kinase NLK013334
Serine/threonine-protein kinase 17A011819
Ephrin type-A receptor 6001717
Death-associated protein kinase 2011819
Ribosomal protein S6 kinase alpha-6003434
TRAF2 and NCK-interacting protein kinase013536
Serine/threonine-protein kinase tousled-like 1001717
ALK tyrosine kinase receptor061925
Cyclin-dependent kinase 11A001717
Calcium/calmodulin-dependent protein kinase type II subunit alpha041721
RAC-gamma serine/threonine-protein kinase033437
Serine/threonine-protein kinase 38-like002424
Dual specificity tyrosine-phosphorylation-regulated kinase 1B052126
Mitogen-activated protein kinase kinase kinase kinase 5003434
Serine/threonine-protein kinase MRCK beta003434
Interleukin-1 receptor-associated kinase 3003434
Serine/threonine-protein kinase 24002828
Casein kinase I isoform gamma-3003434
Mitogen-activated protein kinase kinase kinase 4003434
Thiopurine S-methyltransferase0303
Succinate-semialdehyde dehydrogenase, mitochondrial0606
4-aminobutyrate aminotransferase, mitochondrial0708
Dihydropteroate synthase 0011
Chain A, Toluene-4-monooxygenase system protein A0101
Leucine-rich repeat serine/threonine-protein kinase 2061521
Potassium channel subfamily K member 20101020
Rap guanine nucleotide exchange factor 3670067
Potassium voltage-gated channel subfamily A member 30516
Acetylcholinesterase0709
Pteridine reductase 10303
Potassium voltage-gated channel subfamily A member 10617
Potassium voltage-gated channel subfamily H member 201863194
[tau protein] kinase 0101
G2/mitotic-specific cyclin-B2017019
cAMP-dependent protein kinase catalytic subunit alpha0909
Beta-casein0101
Protein kinase C alpha type0909
Cyclin-dependent kinase 10302962
Protein kinase C delta type0909
Protein kinase C epsilon type0909
Protein kinase C zeta type0909
G2/mitotic-specific cyclin-B1026028
Protein kinase C gamma type0909
Protein kinase C beta type0909
Protein kinase C eta type0909
G2/mitotic-specific cyclin-B3017019
Protein kinase C theta type0909
NPYLR7B001212
Plasminogen012214
Chymotrypsin-like elastase family member 10303
Chain A, Nadph Dehydrogenase 10011
Acetylcholinesterase0606
D(1A) dopamine receptor0956108
Toll-like receptor 2 0202
Vpr330033
streptokinase A precursor002929
Neuraminidase0303
Carbonic anhydrase 0909
Beta-carbonic anhydrase 1015015
5-hydroxytryptamine receptor 2C 0607
5-hydroxytryptamine receptor 2A0405
Alpha-2B adrenergic receptor01379153
Alpha-2C adrenergic receptor011812137
5-hydroxytryptamine receptor 1B017321
Nischarin0808
Nischarin011011
Gamma-aminobutyric acid receptor subunit alpha-10341448
Gamma-aminobutyric acid receptor subunit beta-20301141
Prostaglandin G/H synthase 2031032
G-protein coupled bile acid receptor 1052530
Fatty acid synthase0808
Fatty acid synthase 0303
Aldo-keto reductase family 1 member B1055159
Sorbitol dehydrogenase0606
Induced myeloid leukemia cell differentiation protein Mcl-1014014
Chain A, Sulfotransferase 1A10101
Chain A, Sulfotransferase 1A10101
Endolysin0055
UDP-glucuronosyltransferase 1A4013130
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1014115
60 kDa chaperonin025025
60 kDa heat shock protein, mitochondrial029029
Beta-3 adrenergic receptor0412061
Substance-K receptor050051
10 kDa heat shock protein, mitochondrial029029
Thiosulfate sulfurtransferase028028
60 kDa chaperonin 030030
10 kDa chaperonin 030030
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Chain A, TRYPSIN0101
Membrane primary amine oxidase0002
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Histone deacetylase 3029132
Histone deacetylase 4025230
Histone deacetylase 1033439
Histone deacetylase 7025128
Histone deacetylase 2031336
Polyamine deacetylase HDAC10021124
Histone deacetylase 11 022125
Histone deacetylase 8028232
NAD-dependent protein deacylase sirtuin-5, mitochondrial010014
Histone deacetylase 6032236
Histone deacetylase 9025128
Histone deacetylase 5026129
P2Y purinoceptor 20167
P2Y purinoceptor 40033
P2Y purinoceptor 60167
Melatonin receptor type 1A06410
Melatonin receptor type 1B0549
Tumor necrosis factor receptor superfamily member 1A0202
Rapamycin-insensitive companion of mTOR0202
Regulatory-associated protein of mTOR0404
Phosphatidylinositol 3-kinase catalytic subunit type 30112
Target of rapamycin complex 2 subunit MAPKAP10202
Target of rapamycin complex subunit LST80404
Gamma-aminobutyric acid receptor subunit rho-30012
Gamma-aminobutyric acid receptor subunit rho-10146
Gamma-aminobutyric acid receptor subunit rho-20023
Sodium- and chloride-dependent GABA transporter 10404
Sodium- and chloride-dependent GABA transporter 20606
Sodium- and chloride-dependent GABA transporter 30606
Solute carrier family 15 member 1027129
Chain A, Deoxycytidine kinase0101
Chain A, Deoxycytidine kinase0101
Deoxycytidine kinase012937
D-amino-acid oxidase0718
D-aspartate oxidase0606
Dihydrofolate reductase015018
Thymidylate synthase0606
Trifunctional purine biosynthetic protein adenosine-30202
Bifunctional purine biosynthesis protein ATIC0405
Folylpolyglutamate synthase, mitochondrial0107
Bifunctional purine biosynthesis protein ATIC0101
Cathepsin B010010
HTH-type transcriptional regulator MgrA0101
Genome polyprotein0202
Matrix metalloproteinase-9023023
Lethal factor0808
DNA (cytosine-5)-methyltransferase 10707
Integrase 036340
DNA (cytosine-5)-methyltransferase 3B0202
DNA (cytosine-5)-methyltransferase 3-like0303
DNA (cytosine-5)-methyltransferase 3A0404
BH3-interacting domain death agonist0202
Bcl-2-like protein 10606
Bcl-2 homologous antagonist/killer0101
Transient receptor potential cation channel subfamily V member 4 0123
Trypsin-1014014
Trypsin-2013013
Cyclic AMP-responsive element-binding protein 10002
Trypsin-3013013
nuclear receptor subfamily 0 group B member 10808
steroidogenic factor 10808
Urease subunit alpha016016
Urease subunit beta016016
Nicotinamide N-methyltransferase0202
Dehydrogenase/reductase SDR family member 90202
Solute carrier organic anion transporter family member 2A104011
Cytochrome P450 2E10719
Chain A, 6-PHOSPHOGLUCONATE DEHYDROGENASE0011
6-phosphogluconolactonase 0011
Reverse transcriptase/RNaseH 0221150
caspase-1 isoform alpha precursor300030
Aromatase060068
Aldo-keto reductase family 1 member B1011011
Caspase-7270028
PINK1230023
Sialidase015015
Vesicular glutamate transporter 30404
NPC1-like intracellular cholesterol transporter 10123
Amine oxidase [flavin-containing] A 017220
Nitric oxide synthase, endothelial0608
Nitric oxide synthase, endothelial09010
Nitric oxide synthase, brain015118
Nitric oxide synthase, brain 09011
Nitric oxide synthase, inducible018019
Nitric oxide synthase, inducible012219
Nitric oxide synthase, endothelial 0101
Chain A, Tyrosine 3-monooxygenase0101
Telomerase reverse transcriptase0606
mu-type opioid receptor isoform MOR-10099
5-hydroxytryptamine receptor 2A0099
Translocator protein014520
D(3) dopamine receptor042147
Alpha-2B adrenergic receptor0521467
D(2) dopamine receptor012014
Alpha-2C adrenergic receptor0481463
Alpha-2A adrenergic receptor0501465
Alpha-1D adrenergic receptor010712131
Alpha-1A adrenergic receptor0401771
5-hydroxytryptamine receptor 7035036
D0707
5-hydroxytryptamine receptor 2A0303
Sigma non-opioid intracellular receptor 1190596
Lysosomal alpha-glucosidase0303
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Skn7p0005
glycogen synthase kinase-3 beta isoform 1001919
Adenosine receptor A10202
Trypsin0809
Coagulation factor VII013013
Tissue factor017017
Oxoeicosanoid receptor 10303
Dual specificity protein phosphatase 10101
M-phase inducer phosphatase 20404
Dual specificity protein phosphatase 60101
Histone-lysine N-methyltransferase EHMT2010010
Histone-lysine N-methyltransferase EHMT10707
serine-protein kinase ATM isoform a230023
5'-AMP-activated protein kinase subunit beta-20135
5'-AMP-activated protein kinase subunit gamma-1013638
5'-AMP-activated protein kinase catalytic subunit alpha-10011
5'-AMP-activated protein kinase subunit gamma-30124
5'-AMP-activated protein kinase subunit gamma-2013133
5'-AMP-activated protein kinase subunit beta-10179
Diacylglycerol O-acyltransferase 10404
Diacylglycerol O-acyltransferase 10303
Bone morphogenetic protein receptor type-1B013334
Cell division cycle 7-related protein kinase001717
ATP-dependent RNA helicase DDX3X002929
Pyridoxal kinase002932
Ephrin type-B receptor 6003333
Peroxisomal acyl-coenzyme A oxidase 3002929
Mitotic checkpoint serine/threonine-protein kinase BUB1002525
Dynamin-like 120 kDa protein, mitochondrial002929
Cyclin-T1011011
Eukaryotic translation initiation factor 5B001818
Rho-associated protein kinase 2063440
Serine/threonine-protein kinase ULK1003232
Serine/threonine-protein kinase/endoribonuclease IRE1033336
U5 small nuclear ribonucleoprotein 200 kDa helicase002929
Cyclin-K0303
Cyclin-dependent kinase-like 5002323
Structural maintenance of chromosomes protein 2002828
Mitogen-activated protein kinase kinase kinase 6003232
Guanine nucleotide-binding protein G(i) subunit alpha-2002121
ADP/ATP translocase 2002929
Protein kinase C beta type0153147
Glycogen phosphorylase, liver form012930
Signal recognition particle receptor subunit alpha002626
Cytochrome c1, heme protein, mitochondrial002929
Serine/threonine-protein kinase A-Raf012930
Glycogen phosphorylase, brain form022931
DNA topoisomerase 2-alpha0132654
Cyclin-dependent kinase 40183354
ADP/ATP translocase 3002929
Inosine-5'-monophosphate dehydrogenase 2052632
cAMP-dependent protein kinase type II-alpha regulatory subunit002626
General transcription and DNA repair factor IIH helicase subunit XPD002929
Ras-related protein Rab-6A002727
Multifunctional protein ADE2002929
cAMP-dependent protein kinase catalytic subunit gamma0122840
Ferrochelatase, mitochondrial002929
Ribosomal protein S6 kinase beta-1053035
G1/S-specific cyclin-D1016017
G1/S-specific cyclin-E1011011
Beta-adrenergic receptor kinase 1013334
Probable ATP-dependent RNA helicase DDX6002929
G1/S-specific cyclin-D30607
Heme oxygenase 2002828
S-adenosylmethionine synthase isoform type-2002626
DnaJ homolog subfamily A member 1002929
DNA replication licensing factor MCM4002727
Glycine--tRNA ligase002929
Protein kinase C iota type093443
Exosome RNA helicase MTR4002929
26S proteasome regulatory subunit 6B012930
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha102122
Casein kinase I isoform alpha093444
Elongation factor Tu, mitochondrial002929
Choline-phosphate cytidylyltransferase A001616
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial002929
Ras-related protein Rab-27A002525
Interleukin-1 receptor-associated kinase 1003333
Cyclin-H0808
CDK-activating kinase assembly factor MAT10606
Serine/threonine-protein kinase Nek3003333
Tyrosine--tRNA ligase, cytoplasmic012930
Adenylate kinase 2, mitochondrial002931
Adenosine kinase003031
Ras-related protein Rab-10002828
Actin-related protein 3002929
Actin-related protein 2002828
GTP-binding nuclear protein Ran002929
Cyclin-dependent kinase 60152946
ATP-dependent 6-phosphofructokinase, platelet type002727
DNA topoisomerase 2-beta043144
Macrophage-stimulating protein receptor003333
Protein kinase C zeta type0121426
Mitogen-activated protein kinase kinase kinase kinase 2003333
Dual specificity mitogen-activated protein kinase kinase 5003333
Mitogen-activated protein kinase kinase kinase 1003333
Rho-associated protein kinase 1043337
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0113344
Cyclin-dependent kinase 13013234
Structural maintenance of chromosomes protein 1A002626
Chromodomain-helicase-DNA-binding protein 4002626
Cyclin-dependent kinase 5 activator 1015015
Delta(24)-sterol reductase002828
MAP kinase-activated protein kinase 30088
Myosin light chain kinase 3013233
Uncharacterized aarF domain-containing protein kinase 5001313
Putative heat shock protein HSP 90-beta 2002828
Rab-like protein 3002121
Serine/threonine-protein kinase N3001919
Serine/threonine-protein kinase ULK3003333
Uncharacterized protein FLJ45252002929
Acyl-CoA dehydrogenase family member 11002323
Serine/threonine-protein kinase/endoribonuclease IRE2002828
Serine/threonine-protein kinase TAO1003333
STE20-related kinase adapter protein alpha002929
Myosin-14002727
AarF domain-containing protein kinase 1002929
ATP-dependent RNA helicase DDX42002020
Homeodomain-interacting protein kinase 1031518
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma003232
ATP-dependent RNA helicase DDX1002828
EKC/KEOPS complex subunit TP53RK002929
Mitogen-activated protein kinase kinase kinase 3003333
Eukaryotic translation initiation factor 2-alpha kinase 1003333
Nucleolar GTP-binding protein 1002626
RNA cytidine acetyltransferase002929
Serine/threonine-protein kinase TAO3003333
dCTP pyrophosphatase 1002929
Phenylalanine--tRNA ligase beta subunit002929
Isoleucine--tRNA ligase, mitochondrial001717
Midasin002929
Interleukin-1 receptor-associated kinase 4003333
Cyclin-dependent kinase 12022932
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13012728
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial002626
Serine/threonine-protein kinase TBK1053338
Septin-9002929
Serine/threonine-protein kinase TAO2003333
Serine/threonine-protein kinase ICK003131
Serine/threonine-protein kinase SIK3013334
Mitogen-activated protein kinase kinase kinase 2003333
Thyroid hormone receptor-associated protein 3002323
Receptor-interacting serine/threonine-protein kinase 3022931
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial0505
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial0415
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial0404
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial0404
Solute carrier organic anion transporter family member 1B3054066
Solute carrier organic anion transporter family member 1B1058071
Retinoic acid receptor alpha06921
Retinoic acid receptor beta05918
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70005
ubiquitin carboxyl-terminal hydrolase 2 isoform a670067
Polyunsaturated fatty acid 5-lipoxygenase015023
Potassium voltage-gated channel subfamily E member 1016016
Potassium voltage-gated channel subfamily A member 50606
Potassium voltage-gated channel subfamily KQT member 1017017
Disintegrin and metalloproteinase domain-containing protein 174810058
Potassium voltage-gated channel subfamily D member 3010010
Alpha-glucosidase 0101
Alpha-amylase0101
Pancreatic alpha-amylase010016
Mannosyl-oligosaccharide glucosidase0101
Lysosomal alpha-glucosidase0303
Solute carrier family 22 member 1 076096
Beta-2 adrenergic receptor0482877
Solute carrier family 22 member 1032041
Solute carrier family 22 member 2028033
Major prion protein0088
Trypanothione reductase015018
Solute carrier family 22 member 6031037
UDP-glucuronosyltransferase 1A903113
Bile salt export pump065068
Cytochrome P450 2B10608
Myoglobin0101
Polyunsaturated fatty acid lipoxygenase ALOX15033033
UDP-glucuronosyltransferase 1-6015120
Arachidonate 5-lipoxygenase-activating protein0617
UDP-glucuronosyltransferase 1A1 028142
Cytochrome P450 2J2052054
toxin B0002
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0007
Carbonic anhydrase 018018
GALC protein580058
Carbonic anhydrase 0909
Carbonic anhydrase 012012
Carbonic anhydrase012012
Carbonic anhydrase0606
Prolyl endopeptidase0303
Carbonic anhydrase-related protein 110103
Carbonic anhydrase 20415
Cathepsin B0101
Steryl-sulfatase0608
Carbonic anhydrase 5A, mitochondrial0404
Serum paraoxonase/arylesterase 10909
Dipeptidyl peptidase 4028433
Endochitinase0101
Delta-type opioid receptor044759
Delta-type opioid receptor0421058
Mu-type opioid receptor0561070
Kappa-type opioid receptor038451
Carbonic anhydrase0202
Cholinesterase030031
Fatty-acid amide hydrolase 1219023
Carbonic anhydrase 2011011
Squalene synthase0809
Neuronal acetylcholine receptor subunit alpha-7014722
Carbonic anhydrase, alpha family 011011
Carbonic anhydrase 3013013
Carbonic anhydrase 0909
Sigma intracellular receptor 2015217
Delta carbonic anhydrase0909
Renin0202
Endochitinase A10101
Multidrug resistance-associated protein 10202
Carbonic anhydrase 13016222
Carbonic anhydrase 4011016
Acidic mammalian chitinase0101
Carbonic anhydrase 70101
Carbonic anhydrase 010010
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Free fatty acid receptor 30044
Free fatty acid receptor 20235
Fibrinogen C domain-containing protein 10202
N-alpha-acetyltransferase 500022
Gonadotropin-releasing hormone receptor0437
Putative glycosyltransferase WbgO0001
Killer cell lectin-like receptor subfamily B member 1A0101
Early activation antigen CD690101
Amyloid-beta precursor protein1437457
Alcohol dehydrogenase E chain0729
Alcohol dehydrogenase S chain0729
integrase, partial0606
lens epithelium-derived growth factor p750606
Arginase 0809
Chain E, Purine nucleoside phosphorylase0101
Thymidine kinase 0506
Purine nucleoside phosphorylase0709
Thymidine kinase, cytosolic08016
POU domain, class 2, transcription factor 20103
Purine nucleoside phosphorylase0044
Thymidine kinase 0101
Thymidine kinase0203
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Protein mono-ADP-ribosyltransferase PARP150505
Chain A, Membrane lipoprotein tmpC0033
Chain A, Membrane lipoprotein tmpC0033
Chain A, Membrane lipoprotein tmpC0033
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
signal transducer and activator of transcription 6, interleukin-4 induced6006
high affinity choline transporter 1 isoform a0303
Sodium/nucleoside cotransporter 10505
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 7001818
Sodium/nucleoside cotransporter 20505
Phosphoglycerate kinase 1 0202
Adenosine deaminase0102
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0718
Phosphoglycerate kinase 20202
Heat shock 70 kDa protein 1A 0213
Heat shock cognate 71 kDa protein0022
Endoplasmin0225
Inosine-5'-monophosphate dehydrogenase 1 0405
Streptavidin0022
Adenosylhomocysteinase0207
Adenylate kinase 2, mitochondrial0203
Adenylate kinase isoenzyme 1 0203
Adenosine deaminase 0206
Equilibrative nucleoside transporter 20404
Histone-lysine N-methyltransferase, H3 lysine-79 specific0314
Equilibrative nucleoside transporter 10909
Adenosine kinase0102
5-methylthioadenosine/S-adenosylhomocysteine deaminase0002
Adenosine transporter 10102
Chain A, Heat Shock Protein 900011
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE0011
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN0101
Chain A, Myosin Ie Heavy Chain0011
Chain A, Preprotein translocase secA0011
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, Phosphoribosylformylglycinamidine synthase0101
Chain A, nucleoside diphosphate kinase A0011
Chain B, nucleoside diphosphate kinase A0011
Chain D, DNA polymerase III subunit gamma0011
Chain D, DNA polymerase III subunit gamma0011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30011
Chain A, Kinesin-like protein KIF110101
HPr kinase/phosphorylase0011
ATP-dependent molecular chaperone HSP820113
2-dehydropantoate 2-reductase0246
Endoplasmic reticulum chaperone BiP0314
Pyruvate kinase PKM 0001
Pyruvate kinase PKLR 0001
Heat shock cognate 71 kDa protein0011
5'-nucleotidase0404
P2X purinoceptor 10044
P2Y purinoceptor 10145
P2Y purinoceptor 10044
P2X purinoceptor 10224
P2X purinoceptor 40134
P2X purinoceptor 50022
P2X purinoceptor 60022
P2X purinoceptor 30235
Heat shock protein 75 kDa, mitochondrial0101
P2Y purinoceptor 110145
P2Y purinoceptor 120437
Sensor protein kinase WalK0202
P2X purinoceptor 20123
Transient receptor potential cation channel subfamily M member 20213
Chain A, Glycogen Phosphorylase B0011
Chain B, Glycogen Phosphorylase B0011
Chain A, ADP-dependent glucokinase0101
Chain A, Ribonuclease pancreatic0202
Chain A, Ribonuclease pancreatic0202
Chain A, phosphodiesterase-nucleotide pyrophosphatase0101
Chain A, GLYCOGEN PHOSPHORYLASE B0011
Chain B, GLYCOGEN PHOSPHORYLASE B0011
Chain A, GLYCOGEN PHOSPHORYLASE B0011
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
Adenylate kinase isoenzyme 10002
Fructose-1,6-bisphosphatase 10101
Alkaline phosphatase, tissue-nonspecific isozyme0809
Fructose-1,6-bisphosphatase 10607
Inosine-5'-monophosphate dehydrogenase0102
Amine oxidase [flavin-containing] B024025
GTP:AMP phosphotransferase AK3, mitochondrial0001
Glycine--tRNA ligase0202
Adenosine deaminase-like protein0001
Protease 021737
Histamine H3 receptor011315
Chain A, Carbamoyl-phosphate Synthase0101
Chain A, Potassium-transporting ATPase B chain0011
S-adenosylmethionine synthase isoform type-10102
S-adenosylmethionine synthase isoform type-20102
P2X purinoceptor 20123
P2X purinoceptor 40415
D(1B) dopamine receptor026026
D(4) dopamine receptor028129
D010010
Transient receptor potential cation channel subfamily M member 80349
Transient receptor potential cation channel subfamily M member 80639
WRN230023
histone-lysine N-methyltransferase 2A isoform 2 precursor560056
Tyrosyl-DNA phosphodiesterase 10707
Solute carrier family 22 member 2039049
Polyamine oxidase 10101
Solute carrier family 22 member 3021025
Solute carrier family 22 member 30507
Deoxyhypusine synthase0101
Prostaglandin E2 receptor EP1 subtype06511
Prostaglandin E2 receptor EP4 subtype0618
Prostaglandin E2 receptor EP3 subtype07311
Prostaglandin E2 receptor EP2 subtype0538
Prostacyclin receptor08412
Prostaglandin D2 receptor0325
Histidine triad nucleotide-binding protein 10011
Glutathione reductase, mitochondrial013017
Alanine racemase, biosynthetic0001
Adenosine deaminase0001
Transcriptional activator Myb0303
Poly [ADP-ribose] polymerase 1012517
UDP-N-acetylglucosamine 1-carboxyvinyltransferase0303
UDP-N-acetylglucosamine 1-carboxyvinyltransferase0303
Beta-2 adrenergic receptor 01916
Beta-2 adrenergic receptor091223
Mineralocorticoid receptor 115826
Mineralocorticoid receptor0505
Solute carrier organic anion transporter family member 1A1012025
Adenine phosphoribosyltransferase002020
UMP-CMP kinase 001819
Phosphatidylethanolamine-binding protein 1002222
Myosin-10002121
Electron transfer flavoprotein subunit beta002020
G protein-coupled receptor kinase 6041620
Cysteine--tRNA ligase, cytoplasmic002525
Integrin-linked protein kinase002727
Peroxisomal acyl-coenzyme A oxidase 1002121
Cyclin-dependent kinase 100179
Acyl-CoA dehydrogenase family member 10002525
ATP-dependent RNA helicase DHX30001414
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0066
Misshapen-like kinase 1002424
PAS domain-containing serine/threonine-protein kinase002222
Dual specificity testis-specific protein kinase 2001717
Echinoderm microtubule-associated protein-like 40101
Obg-like ATPase 1002121
Peroxisome proliferator-activated receptor alpha031821
Peroxisome proliferator-activated receptor alpha0167
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0406
Farnesyl pyrophosphate synthase0909
Hypoxanthine-guanine phosphoribosyltransferase0202
Farnesyl pyrophosphate synthase 0404
Farnesyl pyrophosphate synthase 0202
Pepsin A0101
Renin-1 0101
Renin 0202
Cathepsin D 0202
Renin 0101
Protease 018628
Cocaine esterase010011
Procathepsin L0172441
Transient receptor potential cation channel subfamily A member 1001010
Cysteine protease 0404
Mitochondrial 2-oxodicarboxylate carrier0202
Thioredoxin reductase 1, cytoplasmic0707
Bifunctional epoxide hydrolase 2031031
5-lipoxygenase 0404
P2Y purinoceptor 12013114
Thioredoxin reductase 2, mitochondrial0606
Hypoxanthine-guanine phosphoribosyltransferase0208
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0202
Nuclear receptor ROR-gamma0202
Shiga toxin subunit A0202
Histamine H3 receptor08117
Chain A, Xcogt0011
Chain A, Xcogt0011
Chain A, Xcogt0011
Transient receptor potential cation channel subfamily M member 80112
Tissue alpha-L-fucosidase0606
Prolyl endopeptidase FAP0606
Dipeptidyl peptidase 80707
Dipeptidyl peptidase 90606
Dipeptidyl peptidase 20606
Glutamate receptor ionotropic, NMDA 2D09514
Glutamate receptor ionotropic, NMDA 3B09514
Glutamate receptor 10112
Glutamate receptor 20101
Excitatory amino acid transporter 10405
Excitatory amino acid transporter 20405
Excitatory amino acid transporter 30405
Glutamate receptor ionotropic, NMDA 1013518
Glutamate receptor ionotropic, NMDA 2A013518
Glutamate receptor ionotropic, NMDA 2B012619
Glutamate receptor ionotropic, NMDA 2C09514
Glutamate receptor ionotropic, kainate 40202
Glutamate receptor ionotropic, kainate 50404
Glutamate receptor ionotropic, NMDA 3A09514
Glutamate receptor 40101
Glutamate receptor 30101
Botulinum neurotoxin type A 0606
Tyrosine-protein kinase 0011
3-hydroxy-3-methylglutaryl-coenzyme A reductase0808
3-hydroxy-3-methylglutaryl-coenzyme A reductase0202
Chain A, Solute-binding protein0022
Chain A, Solute-binding protein0022
Chain B, SusD0022
Chain A, SusD0022
Chain A, SusD0022
Chain B, Putative Glucanohydrolase Pep1a Glge Isoform 10101
Methylcytosine dioxygenase TET20213
phospholipase A2 precursor0101
cysteine protease ATG4B isoform a0101
DNA dC->dU-editing enzyme APOBEC-3F isoform a170017
Free fatty acid receptor 1021114
Prostaglandin G/H synthase 1 022025
Free fatty acid receptor 40066
Apoptotic peptidase activating factor 10112
Melanocortin receptor 4022527
Melanocortin receptor 5026329
Melanocortin receptor 30167
Melanocortin receptor 50145
Melanocortin receptor 3020525
Melanocortin receptor 40268
Melanocyte-stimulating hormone receptor08513
Melanocyte-stimulating hormone receptor0145
Adrenocorticotropic hormone receptor0011
Carboxylic ester hydrolase 0101
Cytochrome P450 3A60101
UDP-glucuronosyltransferase 2B7014133
Thromboxane-A synthase 024024
Multidrug resistance-associated protein 1 019127
UDP-glucuronosyltransferase 2B10 012113
Gamma-aminobutyric acid receptor subunit gamma-20321143
Cholecystokinin receptor type A112013
Gamma-aminobutyric acid receptor subunit alpha-50311041
Gamma-aminobutyric acid receptor subunit alpha-3031839
Gamma-aminobutyric acid receptor subunit alpha-2031940
Cholecystokinin receptor type A0808
Beta-2 adrenergic receptor013118
Beta-1 adrenergic receptor013524
Prostaglandin E2 receptor EP3 subtype0303
Prostaglandin E2 receptor EP4 subtype0314
Prostaglandin E2 receptor EP1 subtype0303
Nuclear receptor subfamily 4 group A member 20088
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0314
Solute carrier organic anion transporter family member 2A105010
Solute carrier organic anion transporter family member 2B10204
Solute carrier organic anion transporter family member 3A10001
Chain A, Protein (glycogen Phosphorylase)0101
Leukotriene C4 synthase001515
Glycogen synthase kinase-3 beta 0505
[Tau protein] kinase 0505
Dual specificity mitogen-activated protein kinase kinase 7011617
Peripheral plasma membrane protein CASK001515
Inhibitor of nuclear factor kappa-B kinase subunit alpha061521
Mitogen-activated protein kinase kinase kinase 13001515
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma001515
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma001515
Serine/threonine-protein kinase OSR1001515
Serine/threonine-protein kinase Chk2011516
G1/S-specific cyclin-E20404
Vitamin K-dependent protein C0505
Protein kinase C gamma type012215
Wee1-like protein kinase 2001515
Uncharacterized serine/threonine-protein kinase SBK3001515
G2/mitotic-specific cyclin-B010010
Glycogen synthase kinase-3 beta010010
Serine/threonine-protein kinase MAK001515
Receptor tyrosine-protein kinase erbB-3011516
Nucleoside diphosphate kinase B0011
Dual specificity protein kinase CLK10303
G1/S-specific cyclin-D20203
G protein-coupled receptor kinase 4001515
Megakaryocyte-associated tyrosine-protein kinase001515
Serine/threonine-protein kinase Nek4001515
Hormonally up-regulated neu tumor-associated kinase001515
Receptor-interacting serine/threonine-protein kinase 4001515
Cell division control protein 2 homolog001515
Cyclin-A1012114
Serine/threonine-protein kinase PknB001515
Cyclin-dependent kinase-like 1001515
Cyclin homolog0707
Mitogen-activated protein kinase kinase kinase 12001515
Serine/threonine-protein kinase PRP4 homolog001515
Serine/threonine-protein kinase 38001818
Receptor tyrosine-protein kinase erbB-4021517
Rhodopsin kinase GRK1011516
La-related protein 70101
Serine/threonine-protein kinase SBK1001515
Mitogen-activated protein kinase kinase kinase 19001515
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0404
Dual serine/threonine and tyrosine protein kinase001515
Mitogen-activated protein kinase kinase kinase 15001515
Serine/threonine-protein kinase VRK2001515
Cyclin-dependent kinase-like 3001515
Serine/threonine-protein kinase NIM1001515
Serine/threonine-protein kinase ULK2001515
Homeodomain-interacting protein kinase 4021517
Serine/threonine-protein kinase Nek11001515
Serine/threonine-protein kinase 35001515
Rhodopsin kinase GRK7001515
Serine/threonine-protein kinase 32A001515
Dual specificity tyrosine-phosphorylation-regulated kinase 2031518
Cyclin-dependent kinase-like 2001515
Serine/threonine-protein kinase Sgk3001515
Cyclin-dependent kinase 15011517
Serine/threonine-protein kinase RIO2001515
Transient receptor potential cation channel subfamily M member 6001515
Cyclin-dependent kinase 1010010
Homeodomain-interacting protein kinase 2021517
Homeodomain-interacting protein kinase 3031518
SNF-related serine/threonine-protein kinase001515
STE20/SPS1-related proline-alanine-rich protein kinase001515
Long-chain-fatty-acid--CoA ligase 5002020
SRSF protein kinase 3001515
Microtubule-associated serine/threonine-protein kinase 1001515
DNA topoisomerase 1 0101
Retinoic acid receptor gamma 06818
Cannabinoid receptor 205914
Potassium channel subfamily K member 30808
putative alpha-glucosidase4004
Matrix protein 20112
Matrix protein 20123
Multidrug and toxin extrusion protein 1049049
Adiponectin receptor protein 20011
Adiponectin receptor protein 10011
Aminoglycoside 3'-phosphotransferase 0002
Chain U, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Chain A, UROKINASE-TYPE PLASMINOGEN ACTIVATOR0101
Prothrombin019728
Tissue-type plasminogen activator0909
Coagulation factor XI0202
Urokinase-type plasminogen activator0505
Sodium/hydrogen exchanger 10202
Sodium/hydrogen exchanger 10404
Sodium/hydrogen exchanger 30202
Amiloride-sensitive sodium channel subunit alpha0202
Sodium/hydrogen exchanger 20303
Acid-sensing ion channel 10303
Sodium channel protein type 5 subunit alpha042042
Sodium/hydrogen exchanger 50303
Acid-sensing ion channel 30101
Sodium/hydrogen exchanger0101
Chain A, PLASMINOGEN0022
Chain A, PLASMINOGEN0022
Chain A, Apolipoprotein0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0112
Triosephosphate isomerase0404
Steroid 17-alpha-hydroxylase/17,20 lyase0808
Cholesterol side-chain cleavage enzyme, mitochondrial0101
Aromatase0224
Cytochrome P450 11B2, mitochondrial0101
aryl hydrocarbon receptor nuclear translocator0002
transforming acidic coiled-coil-containing protein 30002
Guanine deaminase0405
Solute carrier family 15 member 1010010
Solute carrier family 15 member 2016017
Lysyl oxidase homolog 20101
Protein-lysine 6-oxidase0101
Lysyl oxidase homolog 20101
Lysyl oxidase homolog 30202
Lysyl oxidase homolog 40202
Lysyl oxidase homolog 20303
Dihydrofolate reductase0406
Dihydrofolate reductase0305
Dihydrofolate reductase0538
Folylpolyglutamate synthase, mitochondrial0206
Solute carrier organic anion transporter family member 1A305012
Nicotinate phosphoribosyltransferase011011
ORF730077
microphthalmia-associated transcription factor isoform 90404
Voltage-dependent L-type calcium channel subunit alpha-1C019019
Solute carrier organic anion transporter family member 1A4010021
Voltage-dependent L-type calcium channel subunit alpha-1F046147
Lysine-specific demethylase PHF20101
Thyroid hormone receptor alpha0101
ATP-dependent translocase ABCB1025025
Muscarinic acetylcholine receptor M209811116
Muscarinic acetylcholine receptor M40887100
Muscarinic acetylcholine receptor M5085695
Muscarinic acetylcholine receptor M109612116
Muscarinic acetylcholine receptor M30939107
ATP-dependent translocase ABCB1027634
Carnitine O-palmitoyltransferase 2, mitochondrial0505
Histamine H2 receptor062265
B2 bradykinin receptor0619
C-8 sterol isomerase0808
Sodium channel protein type 1 subunit alpha014014
Sodium channel protein type 4 subunit alpha017020
Squalene synthase0102
C-C chemokine receptor type 2014014
Carnitine O-palmitoyltransferase 1, liver isoform0505
C-C chemokine receptor type 40606
Sodium channel protein type 7 subunit alpha012012
Voltage-dependent L-type calcium channel subunit alpha-1D 046147
Voltage-dependent L-type calcium channel subunit alpha-1S046147
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase09110
Sodium channel protein type 9 subunit alpha019019
Lysine-specific demethylase 7A0101
Carnitine O-palmitoyltransferase 1, muscle isoform0505
Sodium channel protein type 2 subunit alpha015015
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0358
Sodium channel protein type 3 subunit alpha016016
Sodium channel protein type 11 subunit alpha012012
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha012012
Sodium channel protein type 10 subunit alpha013013
Albumin001515
Muscarinic acetylcholine receptor M10342060
Muscarinic acetylcholine receptor M30322259
Muscarinic acetylcholine receptor M40301954
Muscarinic acetylcholine receptor M50301954
Muscarinic acetylcholine receptor M20342060
Angiotensin-converting enzyme069070
D(1B) dopamine receptor016121
UDP-glucuronosyltransferase 1A300113
Voltage-dependent N-type calcium channel subunit alpha-1B012214
Nuclear receptor subfamily 3 group C member 3 051051
Histamine H3 receptor030943
G-protein coupled receptor 350151429
NEDD8-activating enzyme E1 regulatory subunit isoform a0202
NEDD8-conjugating enzyme Ubc120202
Voltage-dependent L-type calcium channel subunit alpha-1C016017
Potassium channel subfamily K member 2 0303
Beta-lactamase 0205
Beta-lactamase 0208
Beta-lactamase 0007
Beta-lactamase 03011
Beta-lactamase 0005
Beta-lactamase SHV-10206
Beta-lactamase SHV-105015
Beta-lactamase03014
B2 metallo-beta-lactamase 0008
Solute carrier family 15 member 2013013
Beta-lactamase 0206
Beta-lactamase 0106
Beta-lactamase 0206
Beta-lactamase 0007
Synaptojanin-20505
Synaptojanin-10505
Substance-P receptor0505
tumor necrosis factor8008
Chain A, Mutant Al2 6e7p9g0011
Beta-lactamase 0408
Beta-lactamase 0309
Beta-lactamase 0108
Metallo-beta-lactamase type 201211
Metallo-beta-lactamase VIM-11 0007
Metallo-beta-lactamase VIM-20007
Beta-lactamase 0109
Metallo-beta-lactamase0007
Beta-lactamase 0309
Beta-lactamase OXA-70005
Beta-lactamase 0206
Beta-lactamase 0206
Beta-lactamase 0206
Metallo-beta-lactamase VIM-130108
Efflux transporter 0003
Beta-lactamase 0107
Beta-lactamase Toho-10004
Beta-lactamase 0003
Class D beta-lactamase0307
Metallo-beta-lactamase0006
Beta-lactamase 0309
Beta-lactamase 02310
Metallo-b-lactamase 00013
Carbapenem-hydrolyzing beta-lactamase KPC05014
Beta-lactamase class B VIM-2 01218
Beta-lactamase VIM-1 0108
Chain A, Pol Polyprotein0011
Chain B, Pol Polyprotein0011
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0022
Chain B, Protease0022
Chain A, Protease0101
Chain B, Protease0101
Chain A, protease0101
Chain B, protease0101
Chain A, protease0101
Chain B, protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0202
Chain B, Protease0202
Chain A, Protease0202
Chain B, Protease0202
Chain A, Protease0202
Chain B, Protease0202
Chain A, Protease0202
Chain B, Protease0202
Chain A, Protease0202
Chain B, Protease0202
Chain A, gag-pro-pol polyprotein0101
Chain B, gag-pro-pol polyprotein0101
Chain A, gag-pro-pol polyprotein0101
Chain B, gag-pro-pol polyprotein0101
Chain A, gag-pro-pol polyprotein0101
Chain B, gag-pro-pol polyprotein0101
Albumin0192658
Gag-Pol polyprotein0606
Gag-Pol polyprotein0303
Gag-Pol polyprotein0303
Gag-Pol polyprotein0909
Gag polyprotein0101
Gag-Pol polyprotein0404
Cathepsin D0202
Gag-Pol polyprotein0729
Gag-Pol polyprotein0404
Thromboxane-A synthase0103
DNA polymerase III, partial250025
Aldehyde oxidase 10303
Aldehyde oxidase011013
Aldehyde oxidase 1 0404
Seed linoleate 13S-lipoxygenase-1017025
Probable linoleate 9S-lipoxygenase 50101
Histone acetyltransferase KAT2B0505
Histone acetyltransferase KAT50303
SUMO-activating enzyme subunit 10202
Fatty-acid amide hydrolase 1013014
Fatty-acid amide hydrolase 10304
Cannabinoid receptor 1011517
Corticotropin-releasing factor receptor 20404
Lanosterol 14-alpha demethylase017220
Transient receptor potential cation channel subfamily V member 2014519
Nuclear factor NF-kappa-B p105 subunit018020
Signal transducer and activator of transcription 3012316
Hexokinase-20202
Beta-glucuronidase0404
Cholinesterase034135
Gastrin/cholecystokinin type B receptor17211
Testosterone 17-beta-dehydrogenase 3011011
Chain A, retinol dehydratase0101
Glucose-6-phosphate 1-dehydrogenase012114
Type-1A angiotensin II receptor 111618
Type-1B angiotensin II receptor112114
Type-2 angiotensin II receptor113115
Atrial natriuretic peptide receptor 30202
Type-1 angiotensin II receptor0011
Type-1 angiotensin II receptor019632
Type-2 angiotensin II receptor012113
Aminopeptidase N0303
Interleukin-1 receptor antagonist protein0101
Endoplasmic reticulum aminopeptidase 20101
Endoplasmic reticulum aminopeptidase 10101
Leucyl-cystinyl aminopeptidase0101
M17 leucyl aminopeptidase0303
Chain A, BCL-2-RELATED PROTEIN A100810
PAX800012
hepatitis C virus polyprotein1001
heat shock protein 900077
caspase recruitment domain family, member 150202
Spike glycoprotein082432
receptor-interacting serine/threonine-protein kinase 2 isoform 10202
bcl-2-like protein 11 isoform 10088
Transmembrane protease serine 20102434
Bcl-2-like protein 110002
Replicase polyprotein 1a0172542
Replicase polyprotein 1ab0112435
Angiotensin-converting enzyme 2 0142539
Beta lactamase (plasmid)0404
core protein, partial0202
Protein farnesyltransferase subunit beta0101
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0101
Apelin receptor0336
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0202
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0202
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0202
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0202
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0202
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0202
Chain A, Transthyretin0055
Chain A, Transthyretin0055
Chain A, Transthyretin0055
Chain A, Transthyretin0055
Chain B, Transthyretin0055
Chain A, Transthyretin0055
Chain B, Transthyretin0055
Chain A, Casein kinase II subunit alpha0202
Chain A, Casein kinase II subunit alpha0202
Chain A, Casein Kinase Ii Subunit Alpha0202
Gamma-aminobutyric acid receptor subunit pi025025
Gamma-aminobutyric acid receptor subunit delta025025
Aldo-keto reductase family 1 member B10023027
Poly [ADP-ribose] polymerase tankyrase-10729
Lysozyme C-10202
Myeloperoxidase016016
Beta-glucuronidase0404
Neutrophil elastase022022
Cystic fibrosis transmembrane conductance regulator0279
Mucin-10101
Gamma-aminobutyric acid receptor subunit beta-1027431
Proteasome subunit beta type-5022024
Gamma-aminobutyric acid receptor subunit beta-3031637
Substance-P receptor026029
Peroxisome proliferator-activated receptor gamma022931
Homeobox protein Nkx-2.5 0202
Gamma-aminobutyric acid receptor subunit alpha-4028331
Estrogen receptor0033
Gamma-aminobutyric acid receptor subunit epsilon025025
Lactoperoxidase0409
MO15-related protein kinase Pfmrk 010010
Transcription factor GATA-4 0202
Gamma-aminobutyric acid receptor subunit alpha-6029332
Substance-K receptor021021
Gamma-aminobutyric acid receptor subunit gamma-1025025
Casein kinase II subunit alpha 3018119
NACHT, LRR and PYD domains-containing protein 3 0505
Gamma-aminobutyric acid receptor subunit gamma-3025025
Myocilin0011
Prenyltransferase homolog0006
Poly [ADP-ribose] polymerase tankyrase-208513
Carboxylic ester hydrolase 0405
NADPH oxidase 40404
Estrogen receptor beta0033
Short transient receptor potential channel 50606
Gamma-aminobutyric acid receptor subunit theta025025
2,3-bisphosphoglycerate-independent phosphoglycerate mutase140014
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)0101
Coagulation factor X0101
Tryptophan 5-hydroxylase 10909
E3 ubiquitin-protein ligase Mdm20303
Bifunctional epoxide hydrolase 20101
Bifunctional epoxide hydrolase 20101
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0022
Chain A, SERUM ALBUMIN0022
Calmodulin 03711
Cytosolic phospholipase A2 gamma0202
Muscarinic acetylcholine receptor M10349
Muscarinic acetylcholine receptor09212
Muscarinic acetylcholine receptor M30138
Muscarinic acetylcholine receptor M20118
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0033
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0033
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0033
Cationic amino acid transporter 30202
Vasopressin V2 receptor010415
Oxytocin receptor0459
Vasopressin V1a receptor0235
Vasopressin V1a receptor016521
Vasopressin V1b receptor0347
Vasopressin V2 receptor0011
Vasopressin V1b receptor0315
Translocator protein0203
Oxytocin receptor0314
Vasopressin V2 receptor 0426
Histamine H1 receptor011619
3-hydroxy-3-methylglutaryl-coenzyme A reductase 012012
Multidrug and toxin extrusion protein 2026026
Forkhead box protein O10101
Chain A, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform0101
Chain A, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform0101
CDGSH iron-sulfur domain-containing protein 1017017
Chain A, Hyaluronidase, phage associated0101
Pancreatic alpha-amylase0202
Albumin0315
Urease0506
Prolyl 4-hydroxylase subunit alpha-10001
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20056
Egl nine homolog 10168
Prolyl hydroxylase EGLN30056
Hypoxia-inducible factor 1-alpha inhibitor0102
Solute carrier family 23 member 10101
DNA repair protein RAD52 homolog0606
Neutral amino acid transporter A0505
Neutral amino acid transporter B(0)0505
Amino acid transporter0505
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0202
Metabotropic glutamate receptor 10225
Metabotropic glutamate receptor 20236
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0055
ras protein, partial0055
Rac1 protein0055
cell division cycle 42 (GTP binding protein, 25kDa), partial0055
Prostaglandin-H2 D-isomerase0202
Prostaglandin G/H synthase 2 09011
Fatty acid-binding protein, liver017320
Glutathione hydrolase 1 proenzyme0101
Urotensin-2 receptor0314
4-aminobutyrate aminotransferase, mitochondrial0303
Ras-related protein Rab-2A0055
Rho-associated protein kinase 20505
ubiquitin-conjugating enzyme E2 N0808
Polycomb protein EED0426
HLA class I histocompatibility antigen, A alpha chain 0066
Glycine receptor subunit alpha-1001111
Substance-P receptor012113
Somatostatin receptor type 20202
Somatostatin receptor type 40202
Somatostatin receptor type 30202
Somatostatin receptor type 50202
Sigma intracellular receptor 20718
Heparanase0055
Genome polyprotein 010212
Prolyl 4-hydroxylase, beta polypeptide0003
Beta-1 adrenergic receptor 02913
Patatin-like phospholipase domain-containing protein 20101
Patatin-like phospholipase domain-containing protein 20101
Solute carrier organic anion transporter family member 2B1 09016
Insulin receptor 0606
Dipeptidyl peptidase 40303
Sterol O-acyltransferase 20505
Sterol O-acyltransferase 1010010
Small conductance calcium-activated potassium channel protein 30415
Endothelin receptor type B0101
Atrial natriuretic peptide receptor 10112
Atrial natriuretic peptide receptor 1 0011
cystic fibrosis transmembrane conductance regulator0202
short transient receptor potential channel 6 isoform 10044
Muscarinic acetylcholine receptor M40416
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial0101
Cytochrome c oxidase subunit NDUFA40101
Acyl carrier protein, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10101
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 30101
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 0101
NADH dehydrogenase [ubiquinone] iron-sulfur protein 50101
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial0101
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial0101
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10101
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 60101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 30101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 70101
NADH dehydrogenase [ubiquinone] 1 subunit C20101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 100101
NADH-ubiquinone oxidoreductase chain 10101
NADH-ubiquinone oxidoreductase chain 20101
NADH-ubiquinone oxidoreductase chain 30101
NADH-ubiquinone oxidoreductase chain 4L0101
NADH-ubiquinone oxidoreductase chain 40102
NADH-ubiquinone oxidoreductase chain 50101
NADH-ubiquinone oxidoreductase chain 60101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 70101
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial0101
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial0101
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 80101
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 60101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 50101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial0101
Amine oxidase [flavin-containing] A0304
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 110101
Amine oxidase [flavin-containing] B0405
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 20101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 30101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 20101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 40101
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 120101
Complex I intermediate-associated protein 30, mitochondrial0101
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 90101
Thromboxane A2 receptor 0329
Leukotriene B4 receptor 21248
Myc proto-oncogene protein0203
Sterol O-acyltransferase 10213
Acyl-CoA:cholesterol acyltransferase 0505
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20202
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20202
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20202
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20202
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20202
Microphthalmia-associated transcription factor0003
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a0022
D(3) dopamine receptor isoform e7007
Calcitonin gene-related peptide type 1 receptor0202
Protein-arginine deiminase type-4014014
Melanin-concentrating hormone receptor 10101
Melanin-concentrating hormone receptor 20101
Melanin-concentrating hormone receptor 10719
Diacylglycerol O-acyltransferase 10303
O-acyltransferase0101
Diacylglycerol O-acyltransferase 20202
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0708
Chain A, Diaminopimelate decarboxylase0101
Chain B, Diaminopimelate decarboxylase0101
Chain C, Cytochrome b0101
Chain C, Cytochrome b0101
Cytochrome b0101
Undecaprenyl-diphosphatase0101
Insulin-degrading enzyme0101
Gamma-aminobutyric acid type B receptor subunit 20325
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10325
Gamma-aminobutyric acid type B receptor subunit 10202
V-type proton ATPase subunit S10101
Vacuolar proton pump subunit B 0101
Lysine-specific demethylase 4E0909
Lysine-specific histone demethylase 1A028029
Progesterone receptor0231137
Cytochrome P450 11B1, mitochondrial0303
Sodium- and chloride-dependent GABA transporter 10909
Sodium- and chloride-dependent GABA transporter 20909
Sodium- and chloride-dependent GABA transporter 30909
Prostaglandin G/H synthase 2 010013
Linoleate 9S-lipoxygenase-40303
1-deoxy-D-xylulose 5-phosphate reductoisomerase0505
Sodium- and chloride-dependent betaine transporter0909
Receptor-type tyrosine-protein phosphatase S0303
Prostaglandin G/H synthase 1 011014
Polyunsaturated fatty acid lipoxygenase ALOX15B0101
Canalicular multispecific organic anion transporter 108012
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0101
Nuclear factor erythroid 2-related factor 20003
NAD(P)H dehydrogenase [quinone] 10009
Kelch-like ECH-associated protein 10002
Nuclear factor erythroid 2-related factor 20001
Ubiquitin carboxyl-terminal hydrolase 20505
Ubiquitin carboxyl-terminal hydrolase 70202
Interstitial collagenase021123
Low affinity immunoglobulin epsilon Fc receptor0101
Stromelysin-1015217
Neutrophil collagenase0606
Metabotropic glutamate receptor 50448
Collagenase 3013014
Matrix metalloproteinase-140505
Snake venom metalloproteinase BaP10101
transient receptor potential cation channel subfamily V member 1100010
Voltage-dependent L-type calcium channel subunit alpha-1D010011
Voltage-dependent L-type calcium channel subunit alpha-1S09010
ATP synthase subunit c0011
ATP synthase subunit c 0101
Angiotensin-converting enzyme 026128
Liver carboxylesterase 108021
Angiotensin-converting enzyme010111
Zinc finger protein mex-50011
calpain II, partial0202
envelope glycoprotein0202
photoreceptor-specific nuclear receptor0303
perilipin-5010010
nuclear receptor corepressor 2 isoform 20101
perilipin-1010010
peroxisome proliferator-activated receptor gamma isoform 20101
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a010010
Eyes absent homolog 20303
Polymerase acidic protein0145
Estrogen receptor021215
Eyes absent homolog 30101
Aldo-keto reductase family 1 member C1010010
Estrogen receptor beta011214
Solute carrier family 22 member 120505
Eyes absent homolog 30101
Inosine-5'-monophosphate dehydrogenase 0101
M1-family alanyl aminopeptidase0404
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
Chain A, GTPase KRas, isoform 2B0011
Chain A, GTPase KRas, isoform 2B0011
GTPase KRas0022
Glutaminyl-peptide cyclotransferase0404
Calcium release-activated calcium channel protein 10404
Protein orai-20202
Protein orai-30202
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase0101
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase0101
D-amino-acid oxidase0213
Metabotropic glutamate receptor 50247
Serine racemase0505
Mu-type opioid receptor016426
Chain A, PROTEIN (TRYPSIN)0101
Chain A, PROTEIN (TRYPSIN)0101
Amiloride-sensitive amine oxidase [copper-containing]0102
Steroid C26-monooxygenase0066
Cytochrome P450 1300011
Cytochrome P450 1300011
Proteasome subunit beta type-110203
Calpain-90202
Proteasome subunit alpha type-70203
Calpain-2 catalytic subunit0303
Proteasome subunit beta type-10608
Proteasome subunit alpha type-10203
Proteasome subunit alpha type-20203
Proteasome subunit alpha type-30203
Proteasome subunit alpha type-40203
NF-kappa-B inhibitor alpha0011
Proteasome subunit beta type-80203
Proteasome subunit beta type-90203
Proteasome subunit alpha type-50203
Proteasome subunit beta type-40203
Proteasome subunit beta type-60203
Proteasome subunit beta type-100203
Cathepsin K0101
Proteasome subunit beta type-30203
Proteasome subunit beta type-20608
Proteasome subunit alpha type-60236
Proteasome subunit alpha-type 80203
Proteasome subunit beta type-70203
Gamma-secretase subunit PEN-20416
Acetylcholinesterase041042
Neuraminidase0707
Neuraminidase010010
Aldo-keto reductase family 1 member C2 010010
Cytochrome P450 2B40101
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 20202
Dihydroorotate dehydrogenase 011011
Kappa-type opioid receptor015524
galactokinase5005
hexokinase-4 isoform 1200020
glucokinase regulatory protein200020
Tyrosyl-DNA phosphodiesterase 20202
NAD0205
NADPH--cytochrome P450 reductase0101
Protein-glutamine gamma-glutamyltransferase 20505
Caspase-1212116
M-phase inducer phosphatase 10505
Nuclear factor NF-kappa-B p100 subunit 013013
Transcription factor p65022126
Receptor-type tyrosine-protein phosphatase eta0303
Receptor protein-tyrosine kinase 0202
Single-stranded DNA cytosine deaminase160016
Mucosa-associated lymphoid tissue lymphoma translocation protein 10202
LMP1 [Human herpesvirus 4]0006
Quinone oxidoreductase00011
Chain A, D-MALTODEXTRIN BINDING PROTEIN0011
Chain A, Limit Dextrinase0011
Chain A, Alpha-hemolysin0011
Chain B, Alpha-hemolysin0011
Chain C, Alpha-hemolysin0011
Chain D, Alpha-hemolysin0011
Chain E, Alpha-hemolysin0011
Chain F, Alpha-hemolysin0011
Chain G, Alpha-hemolysin0011
Chain A, Betaine ABC transporter permease and substrate binding protein0011
Chain A, Osmoprotection protein (ProX)0011
Chain A, Glycine betaine/carnitine/choline-binding protein0022
Chain A, Glycine betaine/carnitine/choline-binding protein0022
Chain A, Glycine betaine/carnitine/choline-binding protein0022
Chain A, Glycine betaine/carnitine/choline-binding protein0022
galanin receptor type 30404
Ubiquitin-like modifier activating enzyme 20303
SUMO1 activating enzyme subunit 10303
SUMO-conjugating enzyme UBC90303
DNA polymerase beta0606
DNA polymerase beta0303
Zinc finger protein GLI10303
Env polyprotein 0033
Phosphodiesterase isozyme 4 0101
Non-structural protein 1 0202
Cytochrome P450 26A10202
Retinoic acid receptor RXR-alpha0246
Retinoic acid receptor RXR-beta05510
Retinoic acid receptor RXR-beta0369
Retinoic acid receptor RXR-gamma0369
Retinoic acid receptor RXR-gamma05510
Retinoic acid receptor RXR-alpha0123
Cytochrome P450 26B10101
Peroxisome proliferator-activated receptor delta011011
Neuropeptide Y receptor type 10416
Neuropeptide Y receptor type 20303
Neuropeptide Y receptor type 50404
NPY-Y2 receptor 0101
Neuropeptide FF receptor 10112
Neuropeptide FF receptor 20224
Progesterone receptor0202
Glucocorticoid receptor0528
Androgen receptor0235
Progesterone receptor0213
STAT3, partial0325
signal transducer and activator of transcription 1-alpha/beta isoform alpha0325
transcription factor p65 isoform 10022
Estrogen receptor beta0227
Carbonyl reductase [NADPH] 1012014
Estrogen receptor0227
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)011011
Chain A, Avidin0011
Chain A, Protein (streptavidin)0011
Chain B, Protein (streptavidin)0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin0011
Chain D, Streptavidin0011
Chain A, Streptavidin Complex With Biotin0011
Chain D, Circularly Permuted Core-streptavidin E51/a460011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Core-streptavidin0011
Chain D, Core-streptavidin0011
Chain A, Avidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
Chain A, Streptavidin0011
Chain B, Streptavidin0011
nonstructural protein 10202
green fluorescent protein, partial0101
insulin-degrading enzyme isoform 10022
Receptor-type tyrosine-protein phosphatase beta0003
Mcl-10909
G-protein coupled receptor 35 isoform a0101
G-protein coupled receptor 550314
CPG DNA methylase0202
Multidrug resistance protein CDR10101
Chain A, Protein kinase C, iota0101
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform0101
cAMP-dependent protein kinase catalytic subunit alpha 0202
NAD-dependent protein deacetylase sirtuin-20729
NAD-dependent protein deacetylase sirtuin-108216
Serine/threonine-protein kinase LMTK30101
Beta-1 adrenergic receptor0415
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Chain A, Estrogen-related receptor gamma0011
Estrogen-related receptor gamma0336
GTP-binding protein Rheb0011
Fatty acid-binding protein, heart0505
Somatostatin receptor type 20101
Fatty acid-binding protein, adipocyte0101
Microsomal triglyceride transfer protein large subunit0404
Beta-lactamase0408
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140202
26S proteasome non-ATPase regulatory subunit 30101
Chymotrypsinogen A011011
Cathepsin G0404
Lysosomal protective protein0203
Chymotrypsinogen B0606
26S proteasome regulatory subunit 6A0101
Chymase0101
Proteasome subunit beta type-80101
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
26S proteasome non-ATPase regulatory subunit 80101
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
26S proteasome non-ATPase regulatory subunit 20101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
ATP-dependent Clp protease proteolytic subunit0112
NACHT, LRR and PYD domains-containing protein 3 0808
26S proteasome non-ATPase regulatory subunit 10101
26S proteasome non-ATPase regulatory subunit 130101
Endothelin receptor type B0011
Deoxyhypusine synthase0101
Endothelin-1 receptor0303
Multidrug resistance-associated protein 60001
Solute carrier organic anion transporter family member 1A500013
Solute carrier organic anion transporter family member 1B20107
B2 bradykinin receptor0101
B1 bradykinin receptor0101
major prion protein preproprotein Prp precursor0202
Chain A, CARBONIC ANHYDRASE IV0101
Beta-3 adrenergic receptor07411
Nuclear hormone receptor family member daf-120112
oxysterols receptor LXR-beta isoform 10112
Thymidine phosphorylase0217
Thymidylate kinase0202
Thymidine kinase0003
Thymidylate kinase0404
vasopressin V1b receptor5005
cAMP-dependent protein kinase type I-alpha regulatory subunit0011
cAMP-dependent protein kinase type II-beta regulatory subunit0011
cAMP-dependent protein kinase catalytic subunit beta isoform 10011
relaxin receptor 1 isoform 1100010
relaxin receptor 2 isoform 15005
cAMP-dependent protein kinase catalytic subunit beta isoform 30011
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 90202
Acetylcholine receptor subunit alpha0639
Acetylcholine receptor subunit gamma0639
Integrin alpha-50101
Acetylcholine receptor subunit beta0639
Neuronal acetylcholine receptor subunit beta-2011215
Neuronal acetylcholine receptor subunit beta-408212
Neuronal acetylcholine receptor subunit alpha-309211
Neuronal acetylcholine receptor subunit alpha-708412
Neuronal acetylcholine receptor subunit alpha-4010214
Acetylcholine receptor subunit delta0639
Alpha-2A adrenergic receptor0303
Tripeptidyl-peptidase 20303
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0606
Mu-type opioid receptor0101
Chain A, Nitrile Hydratase alpha subunit0101
Chain B, Nitrile Hydratase beta subunit0101
Methyl-accepting chemotaxis protein NahY0033
Membrane-associated progesterone receptor component 1001717
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0101
RNA polymerase beta subunit (EC 2.7.7.6), partial0202
90-kda heat shock protein beta HSP90 beta, partial0707
heat shock protein HSP 90-alpha isoform 207019
Lipoxygenase 0101
Tyrosine-protein phosphatase non-receptor type 70606
Dual specificity protein phosphatase 30505
Hyaluronidase-10303
BiP isoform A0101
Aldo-keto reductase family 1 member A10303
Aldo-keto reductase family 1 member C40606
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0022
Chain A, glycogen phosphorylase, liver form0022
Chain A, Glycogen phosphorylase, liver form0022
Chain A, Glycogen phosphorylase, liver form0022
Chain A, Chitinase0101
Glycogen phosphorylase, liver form0303
Glycogen phosphorylase, muscle form0101
Chitotriosidase-10415
Adenosine receptor A2b0103
Palmitoleoyl-protein carboxylesterase NOTUM0235
Endochitinase B10415
electroneutral potassium-chloride cotransporter KCC20022
TSHR protein5005
LacZ protein (plasmid)0033
XBP10202
type-1 angiotensin II receptor0303
apelin receptor0404
DNA damage-inducible transcript 3 protein0202
heat shock protein 90, putative00012
Chain A, Vitamin D Nuclear Receptor0011
Vitamin D3 receptor0011
Vitamin D-binding protein0011
Vitamin D3 receptor0113
Vitamin D3 receptor0022
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0213
Vitamin D3 receptor0112
Transporter011011
Vitamin D3 receptor A0022
Interleukin-20044
Serine protease hepsin0404
Furin0303
Hepatocyte growth factor activator0101
Transmembrane protease serine 60202
DNA topoisomerase 0101
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor0011
Type-2 restriction enzyme ScaI0101
Deoxyribonuclease-2-alpha0101
Deoxyribonuclease-10101
Type-2 restriction enzyme PstI0101
Type-2 restriction enzyme EcoRI0101
DNA ligase0202
Heterogeneous nuclear ribonucleoprotein A10022
DNA topoisomerase 1012325
Type-2 restriction enzyme BamHI0101
Somatostatin receptor type 10101
Type-2 restriction enzyme HindIII0101
Ribonuclease pancreatic0202
DNA topoisomerase 10203
DNA topoisomerase 10101
DNA topoisomerase type IB small subunit 0011
Cruzipain014014
NEDD8-activating enzyme E1 regulatory subunit0235
NEDD8-activating enzyme E1 catalytic subunit0134
DNA polymerase kappa0101
DNA polymerase iota0202
DNA polymerase eta0202
Cytochrome P450 2C11 0303
Steroid 17-alpha-hydroxylase/17,20 lyase 0303
Cytochrome P450 3A70202
N-acylethanolamine-hydrolyzing acid amidase0505
Heat sensitive channel TRPV30123
Transient receptor potential cation channel subfamily V member 40448
G-protein coupled receptor 550135
Diacylglycerol lipase-alpha0505
Inhibin alpha chain0101
Transient receptor potential cation channel subfamily V member 30112
Transient receptor potential cation channel subfamily V member 40213
Transient receptor potential cation channel subfamily V member 20213
Chain A, Beta-lactoglobulin0011
Chain A, Beta-lactoglobulin0011
UDP-3-O-acyl-N-acetylglucosamine deacetylase0011
NADH-ubiquinone oxidoreductase chain 10202
Chain A, angiotensin converting enzyme0101
Chain A, angiotensin converting enzyme0101
Neprilysin0101
Neprilysin0404
Leukotriene A-4 hydrolase011112
EEF1AKMT4-ECE2 readthrough transcript protein0101
Leukotriene A-4 hydrolase0101
Endothelin-converting enzyme 10101
Succinyl-diaminopimelate desuccinylase0505
Beta-lactamase TEM010018
Beta-lactamase 0305
Beta-lactamase 0303
Neuronal acetylcholine receptor subunit alpha-309414
Neuronal acetylcholine receptor subunit alpha-206310
Neuronal acetylcholine receptor subunit beta-305410
Neuronal acetylcholine receptor subunit beta-409414
Neuronal acetylcholine receptor subunit alpha-50539
Neuronal acetylcholine receptor subunit alpha-606411
Neuronal acetylcholine receptor subunit alpha-90539
Neuronal acetylcholine receptor subunit alpha-100539
Sodium channel protein type 1 subunit alpha1708
Sodium channel protein type 2 subunit alpha19111
Sodium channel protein type 3 subunit alpha1607
Frizzled-80011
Oxytocin receptor0022
Lactoperoxidase0202
Chain A, serum paraoxonase0101
Kappa-type opioid receptor018626
Sodium/hydrogen exchanger 10101
Sodium/hydrogen exchanger 30101
Sodium/hydrogen exchanger 30101
Sodium/hydrogen exchanger 20101
Tyrosine-protein phosphatase 10303
C-terminal-binding protein 19009
Glutathione reductase0202
Solute carrier family 22 member 50002
Solute carrier family 22 member 50203
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50002
Secreted chorismate mutase0404
Toll-like receptor 40202
Potassium channel subfamily K member 100101
Chain A, Protein kinase CK2, alpha Subunit0101
Chain A, PROTEIN KINASE CK2, alpha SUBUNIT0101
Chain A, Protein Kinase Ck2, Alpha Subunit0101
Serine/threonine-protein kinase Sgk10303
Casein kinase II subunit alpha 0202
Casein kinase II subunit beta0202
Chain A, Neutrophil gelatinase-associated lipocalin0011
3-dehydroquinate synthase0203
Potassium-transporting ATPase subunit beta0102
Potassium-transporting ATPase alpha chain 10102
Autoinducer 2-binding periplasmic protein LuxP0404
Solute carrier family 22 member 707012
Solute carrier family 22 member 1109017
Solute carrier family 22 member 706010
Beta-lactamase 0307
Beta-lactamase 0004
Metallo-beta-lactamase VIM-19 0008
Beta-lactamase 0308
Beta-lactamase0004
Beta-lactamase08016
Beta-lactamase0004
Beta-lactamase0105
Beta-lactamase 0308
Metallo-beta-lactamase VIM-20007
Beta-lactamase 0007
BlaVIM-1 0007
Beta-lactamase 0005
Beta-lactamase 02010
Beta-lactamase 0406
Beta-lactamase 0003
DNA dC->dU-editing enzyme APOBEC-3A isoform a0303
Solute carrier family 22 member 807010
MecA 0202
L-ornithine N(5)-monooxygenase0112
Ubiquitin carboxyl-terminal hydrolase isozyme L10101
Ubiquitin carboxyl-terminal hydrolase isozyme L30202
Nuclear receptor subfamily 4 group A member 10022
Receptor-type tyrosine-protein phosphatase epsilon0404
Tyrosine-protein phosphatase non-receptor type 60909
Tryptophan 2,3-dioxygenase0304
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN0101
Heat shock factor protein 10112
Tyrosine-protein phosphatase non-receptor type 1109011
Regulator of G-protein signaling 170101
Ubiquitin carboxyl-terminal hydrolase 150101
Ubiquitin carboxyl-terminal hydrolase isozyme L50101
Chain A, Carbonic anhydrase II0101
Cytochrome c oxidase subunit 10101
Cytochrome c oxidase subunit 20101
Catechol O-methyltransferase0101
Cytochrome c oxidase subunit 20404
Quinolone resistance protein NorA0607
Prostaglandin G/H synthase 10606
Indoleamine 2,3-dioxygenase 10909
Prostaglandin G/H synthase 2011012
Prostaglandin G/H synthase 10101
Cyclooxygenase-2 0202
C-C chemokine receptor type 70202
C-C chemokine receptor type 50202
Beta-lactamase OXA-100002
Beta-lactamase 0005
Beta-lactamase IMP-1 0005
Beta-lactamase 0005
Genome polyprotein 0505
Caspase-20022
Stromal cell-derived factor 10101
Polyunsaturated fatty acid 5-lipoxygenase0202
Sortase A0303
Ileal sodium/bile acid cotransporter0609
Bile acid receptor0134
Dihydroxyacetone phosphate acyltransferase0002
30S ribosomal protein S608110
30S ribosomal protein S708110
50S ribosomal protein L1508110
50S ribosomal protein L1008110
50S ribosomal protein L1108110
50S ribosomal protein L7/L1208110
50S ribosomal protein L1908110
50S ribosomal protein L108110
50S ribosomal protein L2008110
50S ribosomal protein L2708110
50S ribosomal protein L2808110
50S ribosomal protein L2908110
50S ribosomal protein L3108110
50S ribosomal protein L31 type B08110
50S ribosomal protein L3208110
50S ribosomal protein L3308110
50S ribosomal protein L3408110
50S ribosomal protein L3508110
50S ribosomal protein L3608110
30S ribosomal protein S1008110
30S ribosomal protein S1108110
30S ribosomal protein S1208110
30S ribosomal protein S1308110
30S ribosomal protein S1608110
30S ribosomal protein S1808110
30S ribosomal protein S1908110
30S ribosomal protein S2008110
30S ribosomal protein S208110
30S ribosomal protein S308110
30S ribosomal protein S408110
30S ribosomal protein S508110
30S ribosomal protein S808110
30S ribosomal protein S908110
50S ribosomal protein L1308110
50S ribosomal protein L1408110
50S ribosomal protein L1608110
50S ribosomal protein L2308110
30S ribosomal protein S1508110
50S ribosomal protein L1708110
50S ribosomal protein L2108110
50S ribosomal protein L3008110
50S ribosomal protein L608110
30S ribosomal protein S1408110
30S ribosomal protein S1708110
30S ribosomal protein S108110
50S ribosomal protein L1808110
50S ribosomal protein L208110
50S ribosomal protein L308110
50S ribosomal protein L2408110
50S ribosomal protein L408110
50S ribosomal protein L2208110
50S ribosomal protein L508110
30S ribosomal protein S2108110
50S ribosomal protein L2508110
50S ribosomal protein L36 208110
Methionine--tRNA ligase, mitochondrial0011
calcineurin A1, putative0022
hepatocyte nuclear factor 4-alpha isoform 20303
protein AF-9 isoform a0005
melanocortin receptor 40213
CAAX prenyl protease0002
bcl-2-related protein A10606
hexokinase HKDC10213
DNA repair protein RAD52 homolog isoform a0008
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Spermine oxidase0101
1,3-beta-D-glucan synthase catalytic subunit 0101
Dihydrofolate reductase 0303
Riboflavin-binding protein0235
Histidine-rich protein PFHRP-II0506
Spike glycoprotein0336
DNA ligase 10101
Calcium-dependent protein kinase 10011
DNA ligase A0101
Phosphoethanolamine N-methyltransferase0101
Cysteine proteinase falcipain 2a 0303
Cysteine proteinase falcipain 2a 0101
MBT domain-containing protein 10202
Lethal(3)malignant brain tumor-like protein 40202
Lethal(3)malignant brain tumor-like protein 30202
Chloroquine resistance transporter0303
Lethal(3)malignant brain tumor-like protein 10202
NADPH oxidase 10404
Snq2p0008
Adenylate cyclase type 1 0404
Major prion protein0112
Cys-loop ligand-gated ion channel0101
Sphingomyelin phosphodiesterase0303
Adenylate cyclase type 30404
Adenylate cyclase type 20415
Adenylate cyclase type 40404
Pleiotropic ABC efflux transporter of multiple drugs08016
Adenylate cyclase type 80404
Gastrin/cholecystokinin type B receptor0505
Adenylate cyclase type 60404
Adenylyl cyclase 7 0404
Acetylcholinesterase 0202
Carboxylic ester hydrolase 0202
LAP40011
RPL19A0022
Cytochrome P450 1440055
Steroid C26-monooxygenase0055
Cholesterol 24-hydroxylase0336
Phospholipase A20325
G-protein coupled bile acid receptor 10123
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Acetylcholinesterase0022
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10608
Solute carrier family 22 member 20506
Sodium- and chloride-dependent creatine transporter 10101
High affinity choline transporter 10101
Chain A, Glycogen phosphorylase, muscle form0101
Chain A, Glycogen phosphorylase, muscle form0101
Chain A, Breast cancer type 1 susceptibility protein100010
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0112
15-hydroxyprostaglandin dehydrogenase [NAD(+)]0101
Voltage-dependent T-type calcium channel subunit alpha-1H0202
Potassium-transporting ATPase alpha chain 10202
Potassium-transporting ATPase subunit beta0202
Solute carrier family 22 member 40404
Extracellular calcium-sensing receptor0011
Platelet glycoprotein VI0258
shiga toxin 1 variant A subunit2002
shiga toxin 1 B subunit2002
Cell division protein FtsZ0115
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0203
DNA gyrase subunit A08012
DNA gyrase subunit B08012
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0304
DNA gyrase subunit A0203
Multidrug resistance protein MdtK0022
DNA gyrase subunit B0608
DNA gyrase subunit A0709
Enoyl-[acyl-carrier-protein] reductase [NADH]0409
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Sodium-dependent noradrenaline transporter0606
Sodium-dependent serotonin transporter0606
Sodium-dependent dopamine transporter0909
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, Proto-oncogene Tyrosine-protein Kinase Src0303
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase0011
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase0011
Beta-lactamase0202
3-dehydroquinate dehydratase0011
ATP-citrate synthase 0405
Ribonuclease T0001
Cell death-related nuclease 40001
3-dehydroquinate dehydratase0011
Prolyl 4-hydroxylase0404
Alpha-ketoglutarate-dependent dioxygenase FTO0404
N(G),N(G)-dimethylarginine dimethylaminohydrolase 109011
General amino-acid permease GAP10001
kallikrein-5 preproprotein0202
Beta-lactamase 0303
Beta-lactamase OXA-10304
Beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0202
Histamine H3 receptor0628
Histamine H4 receptor0347
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
Macrophage metalloelastase0606
mitogen-activated protein kinase kinase kinase kinase 2 isoform 10011
mitogen-activated protein kinase kinase kinase 3 isoform 10011
Trypanothione reductase0101
Envelope glycoprotein0044
Translocator protein0202
Translocator protein08110
Alpha-1B adrenergic receptor 0033
Alpha-1A adrenergic receptor011314
Alpha-2B adrenergic receptor0406
Alpha-2C adrenergic receptor0406
Alpha-2A adrenergic receptor0406
Prostaglandin F2-alpha receptor0437
D(2) dopamine receptor0202
D(3) dopamine receptor0202
D(2) dopamine receptor0606
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 40528
5-hydroxytryptamine receptor 1A0505
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Muscarinic acetylcholine receptor M20134
Lysosomal Pro-X carboxypeptidase0202
Leukotriene B4 receptor 11417
Cytochrome P450 2D10505
Cytochrome P450 2D260606
Cytochrome P450 2D30606
Cytochrome P450 2D40606
Mas-related G-protein coupled receptor member X20099
Vesicular acetylcholine transporter0101
Tubulin polymerization-promoting protein0011
Adenylate cyclase type 80112
Relaxin receptor 10011
Nuclear receptor subfamily 1 group I member 20066
TPA: protein transporter TIM230404
Sterol 14-alpha demethylase0426
RNA-directed RNA polymerase 0337
Receptor-type tyrosine-protein phosphatase F0606
Receptor-type tyrosine-protein phosphatase alpha0303
Exportin-10101
NAD-dependent histone deacetylase SIR20307
Acetylcholinesterase010010
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal0404
Zn finger protein 0101
SUMO-10303
rac GTPase-activating protein 1 isoform a0606
N-arachidonyl glycine receptor0213
Acetyl-CoA carboxylase 20101
Acetyl-CoA carboxylase 1 0101
Acetyl-CoA carboxylase 10101
Acetyl-CoA carboxylase 0101
Sodium- and chloride-dependent creatine transporter 10101
ATP-binding cassette sub-family C member 90123
ATP-binding cassette sub-family C member 806410
ATP-sensitive inward rectifier potassium channel 110538
ATP-sensitive inward rectifier potassium channel 80011
Alkaline phosphatase, germ cell type0202
G protein-coupled receptor GPR350033
G-protein coupled receptor 350022
isocitrate dehydrogenase 1, partial180018
Papain0303
Receptor-type tyrosine-protein phosphatase C0202
Tyrosine-protein phosphatase non-receptor type 90101
Phosphotyrosine protein phosphatase 0303
Low molecular weight protein-tyrosine phosphatase A0202
Tyrosine-protein phosphatase non-receptor type 120202
Tyrosine-protein phosphatase non-receptor type 220202
toll-like receptor 90101
TPA: protein transporter TIM100505
hypothetical protein SA14220101
Heme oxygenase 1 0606
Glutathione S-transferase P0505
Microtubule-associated protein tau0517
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Heme oxygenase 20505
Thioredoxin reductase 1, cytoplasmic0405
Thioredoxin reductase 30303
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Thioredoxin reductase 2, mitochondrial0303
Lymphocyte antigen 960022
Protein phosphatase 1A0101
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit0101
Solute carrier organic anion transporter family member 1A20109
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform0101
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B 0101
Chain A, Homo sapiens cyclin-dependent kinase 20101
Chain C, Cell division protein kinase 20101
Chain C, Cell division protein kinase 20101
Dual specificity protein kinase CLK20202
Dual specificity protein kinase CLK30202
Dual specificity protein kinase CLK40202
Dual specificity tyrosine-phosphorylation-regulated kinase 30202
cGMP-dependent protein kinase 1 0101
Synapsin-10101
Cyclin-C0314
Casein kinase I isoform alpha0101
Cyclin-dependent-like kinase 50101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0202
Cyclin-dependent kinase 200102
Multidrug resistance-associated protein 50203
Interferon regulatory factor 30011
Stimulator of interferon genes protein0156
Stimulator of interferon genes protein0347
transactivating tegument protein VP16 [Human herpesvirus 1]0606
COUP transcription factor 2 isoform a0101
Eukaryotic initiation factor 4A-I0213
Peptidyl-prolyl cis-trans isomerase FKBP1A0628
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10516
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
Integrin beta-10303
Integrin alpha-40303
Smoothened homolog0202
Sonic hedgehog protein0101
Sonic hedgehog protein0112
Smoothened homolog0314
Transcription intermediary factor 1-alpha0202
E3 ubiquitin-protein ligase TRIM330202
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
D-alanine--D-alanine ligase0101
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 0101
chaperonin GroEL4004
Glycogen phosphorylase, muscle form0202
Histone-lysine N-methyltransferase SETD7010010
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0303
nuclear receptor coactivator 3 isoform a0303
Thymidine kinase 2, mitochondrial0101
Thymidine kinase0203
Thymidylate synthase0407
Thymidine kinase0101
Probable deoxycytidylate deaminase0002
Cytidine deaminase0206
Enoyl-[acyl-carrier-protein] reductase [NADH] 0404
Deoxynucleoside kinase0101
Uridine-cytidine kinase 1 0002
Ribonucleoside-diphosphate reductase large subunit0103
Ribonucleoside-diphosphate reductase subunit M20002
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0022
Ribonucleoside-diphosphate reductase subunit M2 B0002
neutrophil cytosol factor 10505
Solute carrier family 2, facilitated glucose transporter member 30101
Solute carrier family 2, facilitated glucose transporter member 40101
Deoxycytidine kinase0001
Alpha-tocopherol transfer protein0011
Coagulation factor XII0404
RAD510202
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 10101
Growth factor receptor-bound protein 20102
Pantothenate synthetase0303
Growth factor receptor-bound protein 2 0101
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase0011
Aldehyde dehydrogenase, mitochondrial0415
Chain A, Aldehyde Dehydrogenase, Mitochondrial0101
Retinal dehydrogenase 20101
Retinal dehydrogenase 10303
Aldehyde dehydrogenase X, mitochondrial0101
Aldehyde dehydrogenase family 1 member A30101
Chain B, Retinoid X receptor, alpha0011
Casein kinase II subunit alpha0202
Sodium/glucose cotransporter 20213
Sodium/myo-inositol cotransporter 20202
Solute carrier family 5 member 40404
Glandular kallikrein0101
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
Dihydrofolate reductase0404
Chain A, Pol Polyprotein0101
Chain A, Pol Polyprotein0101
Chain B, Pol Polyprotein0101
Chain A, Pol Polyprotein0101
Chain B, Pol Polyprotein0101
Chain A, HIV-1 Protease0101
Chain B, HIV-1 Protease0101
Chain A, protease0101
Chain B, protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease (Retropepsin)0011
Chain B, Protease (Retropepsin)0011
Chain A, Protease (Retropepsin)0011
Chain B, Protease (Retropepsin)0011
Chain A, HIV-1 Protease0101
Chain B, HIV-1 Protease0101
Chain A, HIV-1 Protease0101
Chain B, HIV-1 Protease0101
Chain A, HIV-1 Protease0101
Chain B, HIV-1 Protease0101
Chain A, HIV-1 Protease0101
Chain B, HIV-1 Protease0101
Chain A, HIV-1 Protease0101
Chain B, HIV-1 Protease0101
Chain A, HIV-1 Protease0101
Chain B, HIV-1 Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, HIV-1 protease0011
Chain B, HIV-1 protease0011
Chain A, HIV-1 protease0011
Chain B, HIV-1 protease0011
Chain A, HIV-1 Protease0011
Chain B, HIV-1 Protease0011
Chain A, Protease0011
Chain B, Protease0011
Chain A, HIV-1 protease0101
Chain B, HIV-1 protease0101
Chain A, HIV-1 protease0101
Chain B, HIV-1 protease0101
Chain A, HIV-1 protease0101
Chain B, HIV-1 protease0101
Chain A, Protease0011
Chain B, Protease0011
Chain A, Pol polyprotein0101
Chain B, Pol polyprotein0101
Gag-Pol polyprotein0101
Tyrosine-protein kinase ABL10202
Proto-oncogene tyrosine-protein kinase Src0336
Proto-oncogene tyrosine-protein kinase LCK 0202
Tyrosine-protein kinase Blk0101
Myelin transcription factor 10101
Breakpoint cluster region protein0101
Protein cereblon018426
NF-kappa-B essential modulator0112
exodeoxyribonuclease V subunit RecD0505
exodeoxyribonuclease V subunit RecB0505
exodeoxyribonuclease V subunit RecC0505
Chain A, Odorant binding protein0011
Chain B, Odorant binding protein0011
Lysine-specific demethylase 4A0213
Flavin reductase (NADPH)0044
Lysine--tRNA ligase0101
Beta-glucuronidase0303
Glucose-6-phosphate 1-dehydrogenase 0101
ATP-binding cassette sub-family C member 110002
Solute carrier organic anion transporter family member 1A10003
Chain A, STEROID DELTA-ISOMERASE0011
Steroid Delta-isomerase0011
Thymidine kinase 2 0202
AAA family ATPase 0002
AAA family ATPase 0001
Sterol O-acyltransferase 10202
Chain A, Dutpase0011
Chain A, Dutpase0011
Chain B, Dutpase0011
Chain A, Dutpase0011
Chain B, Dutpase0011
Sodium-dependent neutral amino acid transporter B(0)AT20202
Gonadotropin-releasing hormone receptor0415
Cholecystokinin receptor type A09413
Gastrin/cholecystokinin type B receptor06511
Trace amine-associated receptor 10022
Taste receptor type 2 member 460022
caspase 7, apoptosis-related cysteine peptidase0011
caspase-3 isoform a preproprotein0213
Rev0101
Female germline-specific tumor suppressor gld-10101
Monoglyceride lipase0505
Gamma-aminobutyric acid 0426
Alpha-1-acid glycoprotein 10002
Gamma-aminobutyric acid receptor subunit alpha-60426
Gamma-aminobutyric acid receptor subunit gamma-20426
Gamma-aminobutyric acid receptor subunit delta0426
Gamma-aminobutyric acid receptor subunit alpha-20426
Gamma-aminobutyric acid receptor subunit alpha-30426
Gamma-aminobutyric acid receptor subunit gamma-30426
Gamma-aminobutyric acid receptor subunit beta-10426
Gamma-aminobutyric acid receptor subunit alpha-10527
Gamma-aminobutyric acid receptor subunit beta-30426
Gamma-aminobutyric acid receptor subunit alpha-50426
Gamma-aminobutyric acid receptor subunit pi0426
Sphingosine-1-phosphate lyase 10202
Gamma-aminobutyric acid receptor subunit alpha-40426
Gamma-aminobutyric acid receptor subunit theta0426
Gamma-aminobutyric acid receptor subunit gamma-10426
Nicotinamide phosphoribosyltransferase0011
Liver carboxylesterase 10101
Cathepsin B0202
Interleukin-80303
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
C-X-C chemokine receptor type 10202
UDP-glucuronosyltransferase 1A70215
UDP-glucuronosyltransferase 1A1003110
NAD0101
ATP phosphoribosyltransferase0202
Proprotein convertase subtilisin/kexin type 70202
UDP-glucose 4-epimerase0303
Cysteinyl leukotriene receptor 109413
Sodium/potassium-transporting ATPase subunit alpha-1 09010
Sodium/potassium-transporting ATPase subunit beta-109010
Sodium/potassium-transporting ATPase subunit alpha-30607
Sodium/potassium-transporting ATPase subunit beta-20607
Sodium/potassium-transporting ATPase subunit alpha-209010
Sodium/potassium-transporting ATPase subunit alpha-10202
Sodium/potassium-transporting ATPase subunit beta-30607
Sodium/potassium-transporting ATPase subunit gamma0607
Sodium/potassium-transporting ATPase subunit alpha-40607
Solute carrier organic anion transporter family member 4C10306
Chain A, DigA160011
Chain A, DigA160011
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-3 0202
Sodium/potassium-transporting ATPase subunit beta-1 0202
Sodium/potassium-transporting ATPase subunit alpha-40202
Solute carrier organic anion transporter family member 4C10002
Solute carrier organic anion transporter family member 1A40001
Chain A, HTH-type transcriptional regulator qacR0011
Chain B, HTH-type transcriptional regulator qacR0011
Chain A, HTH-type transcriptional regulator qacR0011
Chain B, HTH-type transcriptional regulator qacR0011
Chain A, HTH-type transcriptional regulator qacR0011
Chain A, HTH-type transcriptional regulator qacR0011
Chain B, HTH-type transcriptional regulator qacR0011
Chain A, HTH-type transcriptional regulator qacR0011
Chain B, HTH-type transcriptional regulator qacR0011
fatty acid synthase0202
Chain A, HTH-type transcriptional regulator qacR0011
Chain B, HTH-type transcriptional regulator qacR0011
Chain A, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)0011
Chain B, PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY DEOR-FAMILY)0011
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Leukotriene A-4 hydrolase0202
Chain A, Sex Hormone-Binding Globulin0011
Sex hormone-binding globulin0101
Neuropeptide FF receptor 20003
Cereblon isoform 40808
Insulin-like growth factor-binding protein 50011
Diamine acetyltransferase 10102
Acid-sensing ion channel 10101
Acid-sensing ion channel 20101
Glutathione S-transferase omega-10505
Prostaglandin F2-alpha receptor0202
Prostaglandin F2-alpha receptor0011
Solute carrier organic anion transporter family member 2A10202
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 70001
Catechol O-methyltransferase0215
Histamine N-methyltransferase0102
Ornithine transcarbamylase, mitochondrial0101
Nociceptin receptor0213
urokinase-type plasminogen activator isoform 1 preproprotein1001
LANA0002
kelch-like ECH-associated protein 10003
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0303
3',5'-cyclic-AMP phosphodiesterase 0707
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0303
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0303
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0303
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0303
Exopolyphosphatase PRUNE10101
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0505
Phosphodiesterase 0505
Lipoxygenase 0101
beta-2 adrenergic receptor120113
polypyrimidine tract-binding protein 1 isoform a1001
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0303
Carbamate kinase0101
C-X-C chemokine receptor type 20202
Gasdermin-D0202
Gasdermin-D0202
Kinesin-like protein KIF110101
Nucleotide-binding oligomerization domain-containing protein 20202
Chain A, FATTY ACID-BINDING PROTEIN, BRAIN0022
Chain A, Fatty Acid-binding Protein, Brain0022
Chain A, PFV integrase0101
Chain A, PFV integrase0101
Chain A, PFV integrase0101
Integrase 0011
Vesicular acetylcholine transporter0505
Amine oxidase [flavin-containing] A 0505
Acetylcholinesterase 0707
Cholinesterase0202
Acetylcholine receptor subunit epsilon0123
Carboxylic ester hydrolase 0808
Bone morphogenetic protein 40101
Alpha-1A adrenergic receptor0549
Chain A, peroxisome proliferator activated receptor gamma0101
Lysophosphatidylserine lipase ABHD120202
Monoacylglycerol lipase ABHD60202
N-acetyltransferase Eis0303
3-oxo-5-alpha-steroid 4-dehydrogenase 10303
3-oxo-5-alpha-steroid 4-dehydrogenase 20404
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase0202
Calpain-1 catalytic subunit0101
Pro-cathepsin H0101
Cathepsin S0202
Calpain-1 catalytic subunit0101
Dipeptidyl peptidase 10101
Liver carboxylesterase0101
Cysteine protease falcipain-30101
Cysteine protease falcipain-30101
Arrestin, beta 10101
MPI protein0404
hexokinase0303
hexokinase-1 isoform HKI0011
phosphomannomutase 20101
phosphoethanolamine/phosphocholine phosphatase isoform 10202
eukaryotic translation initiation factor 4 gamma 1 isoform 40505
eukaryotic translation initiation factor 4E isoform 10505
Sulfhydryl oxidase 10101
Insulin-degrading enzyme0303
Toxin B0101
Methionine aminopeptidase 20505
Structural capsid protein 0101
Ultraspiracle0202
20-hydroxy-ecdysone receptor 0202
Ecdysone receptor0101
Protein ultraspiracle0101
Ecdysone receptor0101
Ultraspiracle 0101
20-hydroxy-ecdysone receptor 0101
Ultraspiracle protein 0101
20-hydroxy-ecdysone receptor 0101
Chain A, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, POL POLYPROTEIN0101
Chain B, POL POLYPROTEIN0101
Chain A, Pol Polyprotein0101
Chain B, Pol Polyprotein0101
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 0101
Fructose-1,6-bisphosphatase 1 0002
Reverse transcriptase 0235
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))0101
Chain A, Liver Fatty Acid Binding Protein0011
Chain A, Casein kinase II subunit alpha0101
acetyl-CoA acetyltransferase/HMG-CoA reductase0101
unnamed protein product0202
heat shock 70kDa protein 1A0202
Aldehyde oxidase 10101
glyceraldehyde-3-phosphate dehydrogenase isoform 12002
dual specificity protein phosphatase 30101
mothers against decapentaplegic homolog 3 isoform 10101
heat shock cognate 71 kDa protein isoform 10202
Vif0505
Tat0404
dual specificity protein phosphatase 60101
heat shock cognate 71 kDa protein isoform 20202
Nucleophosmin0101
Glutathione S-transferase Mu 10101
Mitogen-activated protein kinase kinase kinase 80202
DNA primase0303
Tyrosine-protein kinase Lyn 0101
Polypeptide N-acetylgalactosaminyltransferase 20426
ELAV-like protein 30404
Tyrosine-protein kinase Fgr0101
Glutathione S-transferase0101
Translin-associated protein X0101
Cysteine protease ATG4B0101
likely tRNA 2'-phosphotransferase0202
D(2) dopamine receptor isoform long2002
E3 ubiquitin-protein ligase XIAP0404
Macrophage-expressed gene 1 protein0202
NS5 0134
Serine hydrolase RBBP90101
Chain A, PROTEIN KINASE CK2, ALPHA SUBUNIT0101
Chain A, Casein kinase II, alpha chain0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0011
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0011
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ0202
Protein tyrosine phosphatase type IVA 30101
Accessory gene regulator protein A0101
Cytosol aminopeptidase0303
Opioid receptor, delta 1b 0202
Opioid receptor homologue0202
Proenkephalin-B0011
Mu-type opioid receptor0202
V-type proton ATPase subunit B, brain isoform0101
RISC-loading complex subunit TARBP20011
Capsid protein 0134
Histone deacetylase 80303
Histone deacetylase-like amidohydrolase0404
Histone deacetylase 0303
Nuclear receptor corepressor 20808
Apoptosis regulator Bcl-20516
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10011
Chain A, POLYMERASE PA0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
NAD kinase0213
Plasminogen activator inhibitor 10416
Phosphoglycerate mutase 10303
Signal transducer and activator of transcription 1-alpha/beta0112
Bcl-2-related protein A10101
3-oxoacyl-[acyl-carrier-protein] reductase 0101
Bcl-2-like protein 20101
Bcl2-associated agonist of cell death 0101
Bcl-2-like protein 100101
Integrin alpha-V 0213
Adenylate cyclase 0202
Serine/threonine-protein kinase B-raf 0202
Motilin receptor0011
low molecular weight phosphotyrosine protein phosphatase isoform c0101
Motilin receptor0113
Chitinase B0101
ERAP1 protein0002
ERAP2 protein0002
M17 leucyl aminopeptidase0101
M18 aspartyl aminopeptidase0303
M1-family alanyl aminopeptidase0101
leucyl-cystinyl aminopeptidase [Mus musculus]0002
Taste receptor type 2 member 160024
Lanosterol 14-alpha demethylase0033
Sodium/bile acid cotransporter0106
Solute carrier organic anion transporter family member0002
Chain A, GLUTATHIONE TRANSFERASE A1-10101
Chain A, Glutathione S-transferase P1-10101
Chain A, Glutathione S-transferase P1-10101
Chain B, Glutathione S-transferase P1-10101
Hematopoietic prostaglandin D synthase0303
Glutathione S-transferase A10101
14 kDa phosphohistidine phosphatase0404
Chain A, HEAT SHOCK PROTEIN HSP 90-ALPHA0011
Chain A, HEAT SHOCK PROTEIN HSP 90-ALPHA0011
Chain A, Heat Shock Protein Hsp 90-alpha0011
Chain A, HEAT SHOCK PROTEIN HSP 90-ALPHA0011
Chain A, HEAT SHOCK PROTEIN HSP 90-ALPHA0011
Chain A, HEAT SHOCK PROTEIN HSP 90-ALPHA0011
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0505
Nuclear receptor subfamily 1 group I member 3 0202
Voltage-dependent calcium channel subunit alpha-2/delta-10303
Voltage-dependent T-type calcium channel subunit alpha-1I0202
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)0101
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)0101
Acetylcholine receptor subunit alpha0314
Acetylcholine receptor subunit beta0314
Acetylcholine receptor subunit gamma0314
Acetylcholine receptor subunit delta0101
Acetylcholine receptor subunit delta0314
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Acetylcholine receptor subunit beta0101
Cytochrome P450 11B1, mitochondrial0606
Cytochrome P450 11B2, mitochondrial0606
Regulatory protein E20022
DNA topoisomerase 20002
Caspase-30505
DNA topoisomerase 2-alpha 0001
Luciferin 4-monooxygenase0415
Ectonucleotide pyrophosphatase/phosphodiesterase family member 20505
Glucagon-like peptide 1 receptor0022
Glucagon-like peptide 1 receptor0101
Glucagon-like peptide 1 receptor06410
Glucagon receptor0123
NPC1-like intracellular cholesterol transporter 10101
Potassium voltage-gated channel subfamily KQT member 30013
Potassium voltage-gated channel subfamily KQT member 20013
UDP-glucuronosyltransferase 2B110011
UDP-glucuronosyltransferase 2B170011
Potassium voltage-gated channel subfamily KQT member 20011
Potassium voltage-gated channel subfamily KQT member 3 0011
UDP-glucuronosyltransferase 2B40011
UDP-glucuronosyltransferase 2A10011
UDP-glucuronosyltransferase 2A20011
UDP-glucuronosyltransferase 1A50011
UDP-glucuronosyltransferase 2B150011
Potassium voltage-gated channel subfamily KQT member 40011
UDP-glucuronosyltransferase 2A30011
UDP-glucuronosyltransferase 2B280011
UDP-glucuronosyltransferase 1A80018
Potassium voltage-gated channel subfamily KQT member 50012
Potassium voltage-gated channel subfamily KQT member 2 0011
Ceramide glucosyltransferase0303
Beta-galactosidase0303
Chain D, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA0101
Protein farnesyltransferase subunit beta0001
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0001
Geranylgeranyl pyrophosphate synthase0203
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit0202
Chain I, cAMP-dependent protein kinase inhibitor, alpha form0202
Chain B, Rho-associated protein kinase 10202
Chain A, Rho-associated protein kinase 10202
Chain A, Rho-associated protein kinase 10202
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0202
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0202
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0202
Chain I, cAMP-dependent protein kinase inhibitor alpha0202
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0202
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit0202
Chain I, cAMP-dependent protein kinase inhibitor alpha0202
Chain A, Rho-associated protein kinase 10202
cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha10001
cAMP-dependent protein kinase catalytic subunit alpha 0314
C-C motif chemokine 20202
Cell division control protein 42 homolog0202
Ras-related C3 botulinum toxin substrate 10246
Rho-associated protein kinase 20202
Cathepsin B0101
procathepsin L isoform 1 preproprotein0202
fructose-bisphosphate aldolase0101
Methionine aminopeptidase0303
NAD-dependent protein deacetylase HST20303
Fatty acid-binding protein, liver0314
Chloride channel isoform 1 0022
Retinol-binding protein 40033
Prosaposin0011
Indoleamine 2,3-dioxygenase 20707
Aldo-keto reductase family 1 member A10303
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 10101
3-oxo-5-alpha-steroid 4-dehydrogenase 20404
Sphingosine 1-phosphate receptor 10358
RCG53912, isoform CRA_a 0001
Sphingosine kinase 1 0001
Sphingosine kinase 20304
Sphingosine kinase 10304
Chain B, Cell division protein kinase 60101
Dihydroorotate dehydrogenase (fumarate)0202
Dihydroorotate dehydrogenase 0404
Potassium voltage-gated channel subfamily D member 20303
twin arginine protein translocation system - TatA protein0003
Lanosterol 14-alpha demethylase0135
Malate dehydrogenase, cytoplasmic0505
Mycocyclosin synthase0022
Lanosterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0033
14-alpha sterol demethylase 0034
Chain A, Uracil Phosphoribosyltransferase0101
Potassium voltage-gated channel subfamily C member 10101
Gastrin/cholecystokinin type B receptor 0101
Acid-sensing ion channel 30202
Arylacetamide deacetylase0205
Arylacetamide deacetylase0002
Arylacetamide deacetylase0002
Cytochrome P450 1A2 0406
Chain A, Dihydrofolate reductase0011
Multidrug resistance associated protein0206
Chain A, probable fosfomycin resistance protein0011
Chain B, probable fosfomycin resistance protein0011
DNA polymerase catalytic subunit0101
DNA polymerase catalytic subunit0101
DNA polymerase alpha catalytic subunit0202
DNA polymerase delta catalytic subunit0101
Advanced glycosylation end product-specific receptor0112
Menin0112
Lecithin retinol acyltransferase0101
Protein Rev 0022
Fucose-binding lectin PA-IIL0202
CD209 antigen0303
Steroid hormone receptor ERR10505
Methionine aminopeptidase 10101
Holo-[acyl-carrier-protein] synthase0101
Protein mono-ADP-ribosyltransferase PARP100325
Protein-serine O-palmitoleoyltransferase porcupine0101
Poly [ADP-ribose] polymerase 20549
Beta-galactosidase0303
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0022
Jacalin0011
Protein disulfide-isomerase0202
Chain A, ACETYLCHOLINESTERASE0101
Chain A, Acetylcholinesterase0101
L-selectin0101
P-selectin0101
E-selectin0101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Chain A, Glycogen phosphorylase, muscle form0101
Caspase 6, apoptosis-related cysteine peptidase0004
Transitional endoplasmic reticulum ATPase0101
epidermal growth factor receptor isoform a precursor1102
Synaptic vesicular amine transporter0404
Serine/threonine-protein kinase ULK30033
Chain A, DEOXYNUCLEOSIDE KINASE0101
Chain A, Estrogen receptor 1 (alpha)0101
Chain A, Transthyretin0011
Chain A, Transthyretin0011
Steroid hormone receptor ERR20101
Ornithine decarboxylase0202
Solute carrier family 2, facilitated glucose transporter member 40202
Cystic fibrosis transmembrane conductance regulator0011
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]1001
alpha synuclein, partial1001
Glucagon receptor0214
Asialoglycoprotein receptor 10112
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
Metabotropic glutamate receptor 80202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Metabotropic glutamate receptor 10426
Metabotropic glutamate receptor 20112
Metabotropic glutamate receptor 30213
Metabotropic glutamate receptor 40213
Metabotropic glutamate receptor 60112
Metabotropic glutamate receptor 70112
Metabotropic glutamate receptor 80011
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80213
Glutamate carboxypeptidase 20102
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40225
Glutamate racemase0001
Chain A, Glutamine Binding Protein0011
Asc-type amino acid transporter 10202
Glutathione reductase0102
ATP synthase subunit beta, mitochondrial0101
ATP synthase subunit delta, mitochondrial0101
ATP synthase subunit gamma, mitochondrial0101
ATP synthase subunit epsilon, mitochondrial0101
Cholesteryl ester transfer protein0101
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Sodium- and chloride-dependent glycine transporter 10202
Sodium- and chloride-dependent glycine transporter 20202
Bile salt export pump0003
Corticosteroid 11-beta-dehydrogenase isozyme 1 0213
Corticosteroid 11-beta-dehydrogenase isozyme 20101
Lactoylglutathione lyase0101
High mobility group protein B10033
High mobility group protein B10001
4-hydroxy-tetrahydrodipicolinate synthase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
Neuraminidase 0303
Neuraminidase 0303
Neuraminidase0101
Neuraminidase0303
Neuraminidase0101
Sialidase A0101
Neuraminidase0101
Neuraminidase 0101
Neuraminidase0101
Neuraminidase 0303
Neuraminidase0101
Chain A, Estrogen-related receptor gamma0101
Tegument protein VP160022
Polycomb protein SUZ120202
Histone-lysine N-methyltransferase EZH20404
Nuclear receptor subfamily 1 group D member 10246
Chain A, Bromodomain-containing protein 40011
Bromodomain testis-specific protein0123
ATPase family AAA domain-containing protein 20011
guanine nucleotide-binding protein subunit alpha-150224
trace amine-associated receptor 10224
Ricin0202
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0022
Purine nucleoside phosphorylase 0024
Chain A, Probable hydrogenase nickel incorporation protein hypB0011
Chain B, Probable hydrogenase nickel incorporation protein hypB0011
Chain A, ELONGATION FACTOR TU (EF-TU)0011
Chain A, Elongation Factor G0011
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 30011
Chain A, Eukaryotic peptide chain release factor GTP-binding subunit0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0022
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0022
Chain A, interferon-inducible GTPase0011
Chain A, interferon-inducible GTPase0011
Chain A, Elongation factor 20011
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunit0011
Ras-related protein Rab-7a0022
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT50101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90404
Chain A, Hypoxanthine Phosphoribosyltransferase0202
Chain A, HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE0202
Chain A, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE0022
Chain B, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE0022
Chain A, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE0022
Chain A, Xanthine phosphoribosyltransferase0011
Histidine triad nucleotide-binding protein 10011
Chain A, Uracil Phosphoribosyltransferase0011
Chain B, Uracil Phosphoribosyltransferase0011
Chain C, Uracil Phosphoribosyltransferase0011
Chain A, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR0101
Ubiquitin carboxyl-terminal hydrolase 10404
Pre-mRNA-processing factor 190011
WD repeat-containing protein 480404
Melanin-concentrating hormone receptor 10303
Free fatty acid receptor 10022
Chain E, C-amp-dependent Protein Kinase0101
Chain I, Protein Kinase Inhibitor Peptide0101
Chain E, C-amp-dependent Protein Kinase0101
Chain E, C-amp-dependent Protein Kinase0101
Chain I, Protein Kinase Inhibitor Peptide0101
cAMP-dependent protein kinase type II-alpha regulatory subunit0101
cAMP-dependent protein kinase catalytic subunit beta 0101
cAMP-dependent protein kinase type II-beta regulatory subunit0101
Vitamin D-binding protein0101
5-hydroxytryptamine receptor 2A0213
AP-2 complex subunit sigma0101
Zinc finger protein 6640101
Chain A, Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
CDC-like kinase 1, isoform CRA_c0001
dual specificity protein kinase CLK41001
Sodium-dependent dopamine transporter0101
Neuromedin-B receptor0101
Mitogen-activated protein kinase 10202
Serine/threonine-protein kinase haspin0101
Dual specificity tyrosine-phosphorylation-regulated kinase 40101
Chain E, Fibrin beta chain0202
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0002
CDK50002
Chain A, TYROSINE PHOSPHATASE0101
Chain A, Tyrosine Phosphatase0101
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 10404
Valosin-containing protein0101
Estrogen receptor 10202
neuropeptide Y receptor type 10011
neuropeptide Y receptor type 20011
small ubiquitin-related modifier 2 isoform b precursor0101
estrogen receptor beta isoform 10505
enteropeptidase precursor1001
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase1001
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D0202
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D0101
BZLF20101
Platelet glycoprotein 40101
Growth hormone secretagogue receptor type 10428
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
Histamine N-methyltransferase 0101
Equilibrative nucleoside transporter 40001
Histamine H4 receptor0224
Histamine H4 receptor 0101
Chain A, HISTIDINE-BINDING PROTEIN0011
Histidine-binding periplasmic protein0011
Intestinal-type alkaline phosphatase0606
Phospholipase A-2-activating protein0606
Muscarinic receptor M1 0101
Phosphatidylcholine-sterol acyltransferase0011
G-protein coupled receptor 10011
N-glycosylase/DNA lyase0404
Aspartate aminotransferase, cytoplasmic0202
tyrosine-protein phosphatase non-receptor type 7 isoform 20303
Chain A, Carbonic anhydrase 20202
Chain A, Carbonic anhydrase 20202
Chain A, Carbonic anhydrase 20202
Cyclic GMP-AMP synthase0303
Toll-like receptor 90101
Toll-like receptor 70112
Uracil nucleotide/cysteinyl leukotriene receptor0404
Glutamine synthetase0101
Genome polyprotein0202
Oleandomycin glycosyltransferase0001
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial0011
2-5A-dependent ribonuclease0304
Chain A, Purine-nucleoside Phosphorylase0101
Chain C, Xanthine dehydrogenase/oxidase0011
Caspase-40404
Caspase-50404
Caspase-90404
Dehydrogenase/reductase SDR family member 90101
Type-1 angiotensin II receptor0314
Disintegrin and metalloproteinase domain-containing protein 100101
Disintegrin and metalloproteinase domain-containing protein 120101
A disintegrin and metalloproteinase with thrombospondin motifs 40202
Matrix metalloproteinase-150202
Matrix metalloproteinase-160202
Disintegrin and metalloproteinase domain-containing protein 90101
Matrix metalloproteinase-260202
Matrix metalloproteinase-170101
A disintegrin and metalloproteinase with thrombospondin motifs 50202
Prostacyclin receptor0112
Mitogen-activated protein kinase kinase kinase 140303
P2X purinoceptor 70213
Transmembrane protease serine 40101
Epoxide hydrolase 10003
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Beta-lactamase 0203
Toll-like receptor 80011
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
Malate dehydrogenase0505
Kit ligand0101
Chain A, Glycogen Synthase Kinase-3 Beta0101
Chain B, Glycogen Synthase Kinase-3 Beta0101
Chain A, Glycogen Synthase Kinase-3 Beta0101
Phenol oxidase 0101
Integrin beta-20112
Intercellular adhesion molecule 10112
Trp operon repressor0022
Integrin alpha-L0224
Peptide deformylase 1A, chloroplastic/mitochondrial0101
Peptide deformylase 0101
Kynurenine--oxoglutarate transaminase 10101
Chain A, membrane-associated prostaglandin E synthase-20101
Phospholipase A2, major isoenzyme0202
C-X-C chemokine receptor type 30505
Prostaglandin D2 receptor 0202
Prostaglandin D2 receptor 20213
Chain A, ADENOSINE DEAMINASE0101
Chain A, ADENOSINE DEAMINASE0101
Chain A, hypoxanthine phosphoribosyltransferase0011
Chain A, hypoxanthine phosphoribosyltransferase0011
Chain A, Hypoxanthine-guanine phosphoribosyltransferase0101
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
Chain A, BETA-SPECTRIN0011
Chain A, Phospholipase C Delta-10011
Chain A, Inositol 1,4,5-trisphosphate receptor type 10011
Inositol-trisphosphate 3-kinase A0101
Inositol 1,4,5-trisphosphate receptor type 1 0022
Inositol 1,4,5-trisphosphate receptor type 20101
Inositol 1,4,5-trisphosphate receptor type 30112
Inositol polyphosphate-5-phosphatase A0101
Inositol 1,4,5-trisphosphate receptor type 10112
Chain A, Peroxisome proliferator-activated receptor gamma0101
Peptidylglycine alpha-amidating monooxygenase0003
SUMO-1-specific protease0101
SUMO1/sentrin specific peptidase 70101
sentrin-specific protease 80101
Chain A, Acetylcholinesterase0101
3-oxoacyl-[acyl-carrier-protein] synthase 3 0202
Formamidopyrimidine-DNA glycosylase0101
Endonuclease III-like protein 10101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
Chain A, beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Chain A, Beta-galactosidase0101
Beta-galactosidase0101
Beta-2 adrenergic receptor0112
Beta-3 adrenergic receptor0011
Taste receptor type 2 member 380037
Taste receptor type 2 member 390011
Taste receptor type 2 member 400011
Taste receptor type 2 member 410011
Taste receptor type 2 member 430011
Taste receptor type 2 member 310145
Taste receptor type 2 member 450011
Taste receptor type 2 member 300011
Taste receptor type 2 member 190011
Taste receptor type 2 member 200011
Taste receptor type 2 member 500011
Taste receptor type 2 member 600022
Taste receptor type 2 member 420011
Taste receptor type 2 member 140023
Taste receptor type 2 member 130022
Taste receptor type 2 member 100011
Taste receptor type 2 member 90022
Taste receptor type 2 member 80011
Taste receptor type 2 member 70011
Taste receptor type 2 member 50011
Taste receptor type 2 member 40022
Taste receptor type 2 member 30011
Taste receptor type 2 member 10022
Ornithine decarboxylase0002
Retinoic acid receptor alpha0224
Retinoic acid receptor gamma0224
Retinoic acid receptor beta0224
Cellular retinoic acid-binding protein 20022
Cellular retinoic acid-binding protein 10203
Cellular retinoic acid-binding protein 10022
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 20011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 10011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 40011
Sphingosine 1-phosphate receptor 20326
Sphingosine 1-phosphate receptor 40325
Sphingosine 1-phosphate receptor 20101
Sphingosine 1-phosphate receptor 30336
Sphingosine 1-phosphate receptor 50325
Protein E60404
Chain A, Glutamate receptor 20011
Chain A, Glutamate receptor 20011
Chain C, Glutamate receptor 20011
3-oxoacyl-[acyl-carrier-protein] synthase 30112
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
Synaptic vesicular amine transporter0415
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Camphor 5-monooxygenase0001
Steroid 21-hydroxylase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0303
Cytochrome P450 7A1 0101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Period circadian protein homolog 20011
Cryptochrome-10011
Cryptochrome-20011
Leukotriene C4 synthase0202
Leukotriene C4 synthase0001
Prostaglandin E synthase 20101
Presenilin-10314
Presenilin-20314
Gamma-secretase subunit APH-1B0314
Nicastrin0314
Gamma-secretase subunit APH-1A0314
Beta-secretase 20101
Growth hormone secretagogue receptor type 10213
Growth hormone secretagogue receptor type 10101
Chain A, PAPAIN2002
Glyceraldehyde-3-phosphate dehydrogenase0101
bioA0002
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, cellulase0011
Chain A, cellulase0011
Chain A, Galectin-30011
Chain A, Anti-tumor lectin0101
Galectin-30101
Galectin-90022
Galectin-80022
Beta-galactoside-binding lectin0101
Galectin-10124
Galectin-30112
Galectin-30125
Galectin-70022
Alpha 1,4 galactosyltransferase0001
Alpha-crystallin B chain0011
WD repeat-containing protein 50404
Histone-lysine N-methyltransferase 2A0505
Cytosolic endo-beta-N-acetylglucosaminidase0303
matrix metalloproteinase 1, partial0011
Dihydroorotate dehydrogenase (quinone), mitochondrial0202
Dihydroorotate dehydrogenase (quinone), mitochondrial0617
Dihydroorotate dehydrogenase (quinone), mitochondrial0202
DNA-binding protein Ikaros0014
DNA damage-binding protein 10213
Zinc finger protein Aiolos0011
Kinesin-1 heavy chain0101
Nuclear receptor coactivator 40101
Coiled-coil domain-containing protein 60202
Chain A, AMINOPEPTIDASE0202
Chain A, AMINOPEPTIDASE0202
Chain A, Leucine Aminopeptidase0101
Cysteinyl leukotriene receptor 20235
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0303
Intestinal-type alkaline phosphatase0202
Synaptic vesicle glycoprotein 2A0202
SLC16A10 protein0004
Monocarboxylate transporter 100004
CAAX prenyl protease 2 isoform 20001
Retinoic acid receptor, gamma0101
Peroxisome proliferator-activated receptor gamma0202
Retinoic acid receptor RXR-beta0101
Retinoic acid receptor, alpha 0101
Retinoic acid receptor RXR-gamma0101
Isocitrate dehydrogenase [NADP] cytoplasmic0213
Potassium channel subfamily K member 180101
Dipeptidyl peptidase 90202
Dipeptidyl peptidase IV0303
Prolyl endopeptidase FAP0303
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial0101
Renin0202
N-formyl peptide receptor 20123
inositol monophosphatase 12002
Ephrin type-A receptor 20101
Nociceptin receptor0528
Chain A, protease0101
Chain B, protease0101
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, protease0011
Chain B, protease0011
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, Protease0101
Chain B, Protease0101
Chain A, PROTEASE RETROPEPSIN0101
Chain B, PROTEASE RETROPEPSIN0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
Chain A, Protease Retropepsin0101
Chain B, Protease Retropepsin0101
CAAX prenyl protease 1 homolog0101
Plasmepsin V 0202
Potassium channel subfamily K member 90101
5-hydroxytryptamine receptor 2C0011
Chain A, Antigen Cd11a (p180)0101
Queuine tRNA-ribosyltransferase0101
retinoic acid receptor alpha isoform 10101
retinoic acid receptor RXR-alpha isoform a0101
histidine kinase 0101
Chemotaxis protein CheA0101
Protein polybromo-10011
DNA topoisomerase 10101
Chain A, Estrogen receptor0101
Chain A, Estrogen receptor beta0101
Sodium-dependent dopamine transporter0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Lysophosphatidic acid receptor 60011
Lysophosphatidic acid receptor 4 0011
Lysophosphatidic acid receptor 10022
Lysophosphatidic acid receptor 40011
Lysophosphatidic acid receptor 50011
Lysophosphatidic acid receptor 20011
Lysophosphatidic acid receptor 30011
Thymidine phosphorylase0102
Rhodopsin0112
Pancreatic triacylglycerol lipase0303
Carboxylic ester hydrolase 0101
Chain A, Phosphoenolpyruvate carboxykinase0101
D-aspartate oxidase 0101
D-aspartate oxidase0101
Serine racemase0303
Carnitine O-palmitoyltransferase 1, muscle isoform0202
Sphingomyelin phosphodiesterase0101
Alpha-mannosidase 2C10112
C-C chemokine receptor type 50101
Chain A, A disintegrin and metalloproteinase with thrombospondin motifs 50101
Chain A, Catalytic Domain of ADAMTS-50101
Chain A, A disintegrin and metalloproteinase with thrombospondin motifs 50101
Zinc metalloproteinase dpy-310101
Zinc metalloproteinase dpy-310101
ADAM100101
disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein0101
Matrix metalloproteinase-200101
Stromelysin-20101
Matrix metalloproteinase-250101
Matrix metalloproteinase-240101
Acyl-CoA desaturase 10213
Cysteinyl leukotriene receptor 10202
Prostate-specific antigen0101
Calmodulin-domain protein kinase 10101
Neuronal acetylcholine receptor subunit alpha-20202
Transcription factor SOX-180202
Chain H, Prothrombin0101
Chain H, Prothrombin0101
Melatonin receptor type 1C0011
Melatonin receptor type 1A0224
Melatonin receptor type 1C0224
Melatonin receptor type 1B0224
Large neutral amino acids transporter small subunit 1 0202
UDP-glucose 6-dehydrogenase0101
UDP-glucose 6-dehydrogenase0101
UDP-glucuronosyltransferase 1A1 0101
Cystathionine gamma-lyase0404
Cystine/glutamate transporter0101
Hydroxyacid oxidase 10101
Dopamine beta-hydroxylase 0203
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50102
G-protein coupled receptor homolog US280011
G protein-coupled receptor0011
Muscarinic acetylcholine receptor DM10404
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Thymidylate synthase 0101
Thymidylate synthase 0101
ATP-binding cassette sub-family C member 30103
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Dihydrofolate reductase0101
Thymidylate synthase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Folate receptor alpha0101
Histidine decarboxylase0145
Reduced folate transporter0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Trifunctional purine biosynthetic protein adenosine-30101
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Proton-coupled folate transporter0101
Cytochrome P450 2A130549
T cell receptor, partial1001
luteinizing hormone receptor1001
caspase-9 isoform alpha precursor0101
Dihydrolipoyl dehydrogenase, mitochondrial0103
Dihydrolipoyl dehydrogenase 0102
Acidic phospholipase A2 20202
Thioredoxin reductase 0101
Flavodoxin0001
G-protein coupled receptor 0101
Cytochrome P450 1A20101
methionyl-tRNA synthetase, putative0101
Protein delta homolog 10134
Aspartyl/asparaginyl beta-hydroxylase0101
Chain A, PROGESTERONE RECEPTOR0101
Glucocorticoid receptor 0101
Glucocorticoid receptor0112
Glucocorticoid receptor0101
Beta-galactosidase 0101
Alpha-galactosidase0202
Beta-galactosidase0101
Beta-galactosidase0112
Alpha-galactosidase C0101
Lysosomal alpha-mannosidase0101
Alpha-glucosidase0101
Sucrase-isomaltase 0202
Beta-galactosidase0202
Non-lysosomal glucosylceramidase0101
Inner centromere protein0101
Multidrug transporter MdfA0202
Chain A, Probable serine/threonine-protein kinase pknB0101
phospholipase A2, group III0101
histone-lysine N-methyltransferase NSD2 isoform 10001
Bombesin receptor subtype-30213
Bombesin receptor subtype-30224
Bombesin receptor subtype-30213
Stearoyl-CoA desaturase0101
Acyl-CoA (8-3)-desaturase0101
Acyl-CoA 6-desaturase0101
Acyl-CoA desaturase 10202
Acyl-CoA 0101
Acyl-CoA 6-desaturase 0101
Neuropeptide Y receptor type 50101
Glucagon receptor0101
Glucagon receptor0101
Glucagon receptor0101
Vasoactive intestinal polypeptide receptor 10101
Vasoactive intestinal polypeptide receptor 20101
Gastric inhibitory polypeptide receptor0202
Dual specificity protein phosphatase 20101
Nuclear receptor corepressor 10101
Chain A, HEAT SHOCK PROTEIN 900011
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 10101
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 30101
Chain A, Atp-dependent Molecular Chaperone Hsp820011
Chain A, Atp-dependent Molecular Chaperone Hsp820011
Chain B, Type 2 DNA topoisomerase 6 subunit B0011
Chain A, Virulence sensor histidine kinase phoQ0011
Virulence sensor histidine kinase PhoQ0011
ATP-dependent molecular chaperone HSC820101
Proto-oncogene tyrosine-protein kinase Src 0101
Histidine kinase 0101
Islet amyloid polypeptide0101
Low molecular weight phosphotyrosine protein phosphatase0101
DNA-3-methyladenine glycosylase0101
Solute carrier family 22 member 120101
Class A sortase SrtA 0202
Nociceptin receptor0101
Mu-type opioid receptor0101
DNA gyrase subunit B0101
Melanocortin receptor 30011
5-hydroxytryptamine receptor 1B0202
Chain A, Inosine-5'-Monophosphate Dehydrogenase 20101
Inosine-5'-monophosphate dehydrogenase0102
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-10101
Chain A, Pancreatic alpha-amylase0101
Chain A, Pancreatic alpha-amylase0101
Tyrosine-protein kinase transforming protein Fps0101
Solute carrier family 2, facilitated glucose transporter member 20202
Solute carrier family 2, facilitated glucose transporter member 4 0202
DNA primase TraC0101
DNA-(apurinic or apyrimidinic site) endonuclease0202
Cystathionine beta-synthase0101
Aldo-keto reductase family 1 member C210303
RNA-editing ligase 1, mitochondrial0101
Toll-like receptor 20202
Dynamin-10101
Carboxypeptidase B20101
Prostaglandin E synthase0101
Sialidase-40202
Sialidase-10202
Sialidase-30202
Formyl peptide receptor-related sequence 10011
fMet-Leu-Phe receptor0325
FML2_HUMAN 0011
Chain A, Venom Allergen 20011
Muscarinic acetylcholine receptor 0011
Muscarinic acetylcholine receptor 0101
FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)0002
Acid ceramidase0202
Glucose-dependent insulinotropic receptor0011
Glucose-dependent insulinotropic receptor0023
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10001
Adenosine receptor A10213
Adenosine receptor A10202
Adenosine receptor A2a0101
Adenosine receptor A30101
Chain A, ARGINASE 10202
Chain A, Arginase 10202
Chain A, ARGINASE 10202
Arginase-1 0101
Arginase-2, mitochondrial0101
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
kappa-type opioid receptor isoform 10101
Chain A, Cholix toxin0101
Beta-hexosaminidase subunit alpha0101
Hormone-sensitive lipase0202
Chain A, Hth-type Transcriptional Regulator Ttgr0022
Chain A, Hth-type Transcriptional Regulator Ttgr0022
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
Chain A, Mitogen-activated protein kinase 140101
G protein-activated inward rectifier potassium channel 20011
G protein-activated inward rectifier potassium channel 40011
G protein-activated inward rectifier potassium channel 10011
Chain A, ASPARTYLPROTEASE0101
Chain B, ASPARTYLPROTEASE0101
Neuromedin-K receptor0033
Substance-K receptor0134
Neuromedin-K receptor0437
Substance-K receptor0303
Substance-K receptor0303
Neuromedin-K receptor0112
Neuromedin-U receptor 10011
Neuromedin-U receptor 20011
Neuromedin-U receptor 20134
Neuromedin-U receptor 10112
Neurotensin receptor type 10011
Neurotensin receptor type 20113
Myelin basic protein0011
Neurotensin receptor type 10112
Neurotensin receptor type 10337
Neurotensin receptor type 20213
Sortilin0101
Chain B, Hiv-1 Reverse Transcriptase0101
Chain A, Hiv-1 Reverse Transcriptase0101
Chain A, Hiv-1 Reverse Transcriptase0101
Chain A, Hiv-1 Reverse Transcriptase0101
Chain B, Hiv-1 Reverse Transcriptase0101
Chain A, Reverse transcriptase/ribonuclease H0101
Gag-Pol polyprotein0101
Imidazoleglycerol-phosphate dehydratase0101
Ryanodine receptor 10101
Exoribonuclease H 0202
Cardiac ryanodine receptor 2 0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20112
Chain A, NAD-dependent deacetylase0101
Poly [ADP-ribose] polymerase 20101
NAD(+) hydrolase SARM10202
NAD-dependent protein deacetylase sirtuin-60314
NAD-dependent protein deacetylase 0101
Equilibrative nucleoside transporter 10101
B2 bradykinin receptor0505
Anoctamin-10101
Glutamate dehydrogenase 1, mitochondrial 0101
Neuronal acetylcholine receptor subunit alpha-40213
Neuronal acetylcholine receptor subunit alpha-40101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50022
Neuronal acetylcholine receptor subunit alpha-70404
Acetylcholine-binding protein0112
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-60112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Phospholipase A2, membrane associated0102
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Chain A, Phospholipase A2 isoform 30011
Transcriptional enhancer factor TEF-30112
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Voltage-dependent T-type calcium channel subunit alpha-1G0112
Voltage-dependent calcium channel gamma-3 subunit0101
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10304
Voltage-dependent calcium channel gamma-7 subunit0101
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20303
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Voltage-dependent calcium channel gamma-2 subunit0101
4-hydroxyphenylpyruvate dioxygenase0101
4-hydroxyphenylpyruvate dioxygenase 0101
4-hydroxyphenylpyruvate dioxygenase0101
Sodium/iodide cotransporter0202
Platelet-activating factor receptor0101
Nitric oxide synthase, inducible0202
Nitric oxide synthase, brain0202
Nociceptin receptor0134
Corticotropin-releasing factor receptor 10001
Tubulin beta 8B0011
Calcium-activated potassium channel subunit alpha-10102
Calcium-activated potassium channel subunit beta-10001
Ras-related C3 botulinum toxin substrate 10101
Signal transducer and activator of transcription 10101
Signal transducer and activator of transcription 3 0101
Methylated-DNA--protein-cysteine methyltransferase0102
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase0101
Solute carrier family 22 member 190001
STE240001
Protein mono-ADP-ribosyltransferase PARP60202
Protein mono-ADP-ribosyltransferase PARP80011
Protein mono-ADP-ribosyltransferase PARP160224
Protein mono-ADP-ribosyltransferase PARP120202
Protein mono-ADP-ribosyltransferase PARP40325
Protein mono-ADP-ribosyltransferase PARP30347
Hemagglutinin [Cleaved into: Hemagglutinin HA1 chain; Hemagglutinin HA2 chain]0011
Chain A, Adipocyte Lipid-binding Protein0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0022
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0022
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0022
putative potassium channel subunit0011
Glutathione hydrolase 1 proenzyme 0011
Neprilysin0101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
Potassium-transporting ATPase alpha chain 20001
Interleukin-6 receptor subunit alpha0101
Thyrotropin-releasing hormone receptor0101
Glycine receptor subunit alpha-40101
Leukotriene B4 receptor 10101
Phosphatidylserine lipase ABHD16A0101
Lipoprotein lipase0101
Hepatic triacylglycerol lipase0101
Platelet-activating factor acetylhydrolase0203
Neutral cholesterol ester hydrolase 10101
Diacylglycerol lipase-alpha0101
Diacylglycerol lipase-beta0101
Acyl-protein thioesterase 20101
Endothelial lipase0101
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE0101
Solute carrier family 2, facilitated glucose transporter member 90224
Neuraminidase 0202
Neuraminidase0101
Neuraminidase0101
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)0101
Chain L, Igg2b-kappa 40-50 Fab (light Chain)0101
Chain A, Na, K-ATPase alpha subunit0011
Kruppel-like factor 50101
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit beta-30101
Chain A, Pyruvate kinase, M2 isozyme0101
Chain A, Phosphonopyruvate hydrolase0101
Chain A, Phosphoenolpyruvate-protein phosphotransferase0101
L-lactate dehydrogenase C chain0101
Malate dehydrogenase, mitochondrial0101
L-lactate dehydrogenase A chain0101
Malate dehydrogenase, cytoplasmic0101
L-lactate dehydrogenase B chain0101
L-lactate dehydrogenase A chain0101
L-lactate dehydrogenase0101
L-lactate dehydrogenase0101
L-lactate dehydrogenase B chain0101
L-lactate dehydrogenase0101
L-lactate dehydrogenase 0101
polyadenylate-binding protein 10303
Chain A, Bacterial leucyl aminopeptidase0101
Thermolysin0203
Catechol O-methyltransferase0202
metallo beta-lactamase0101
metallo-beta-lactamase IMP-10101
Type 1 InsP3 receptor isoform S2 2002
Apelin receptor0112
Apelin receptor0011
Beta-tubulin 0101
Plasminogen activator inhibitor 10011
Chain B, Cell division protein kinase 60101
Chain B, Cell division protein kinase 60101
Chain A, Fatty acid-binding protein, adipocyte0101
Genome polyprotein0202
Type II pantothenate kinase0001
Type III pantothenate kinase0001
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
Serine hydroxymethyltransferase, mitochondrial0202
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 0202
Pyrroline-5-carboxylate reductase 1, mitochondrial0101
Beta-adrenergic receptor kinase 10202
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50202
G protein-coupled receptor kinase 50101
Beta-adrenergic receptor kinase 10001
Dual specificity mitogen-activated protein kinase kinase 2 0101
Dual specificity mitogen-activated protein kinase kinase 1 0101
Beta-lactamase 10001
Beta-lactamase 0103
Chain C, Respiratory nitrate reductase 1 gamma chain0101
Pentachlorophenol 4-monooxygenase0011
Carnitine O-palmitoyltransferase 2, mitochondrial0303
Aldehyde oxidase 10101
Aldehyde oxidase 10101
Ubiquitin-like modifier-activating enzyme 60101
Ubiquitin-like modifier-activating enzyme ATG70101
Ubiquitin-like modifier-activating enzyme 1 0101
NEDD80101
SUMO-activating enzyme subunit 20101
Macrophage colony-stimulating factor 1 receptor0202
Hydroxysteroid 11-beta dehydrogenase 1 0011
11-beta-hydroxysteroid dehydrogenase type 1 0011
High affinity choline transporter 10101
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Muscarinic acetylcholine receptor M50113
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Ferritin light chain0022
Chain A, Ferritin light chain0022
Chain A, Ferritin light chain0022
Chain A, Ferritin light chain0022
Chain A, Ferritin light chain0022
Chain A, Ferritin light chain0022
Chain A, Ferritin light chain0022
Thymidylate synthase0101
Alpha-1B adrenergic receptor0707
Trace amine-associated receptor 50011
fMet-Leu-Phe receptor0202
Chain A, PROTEIN (CATECHOL OXIDASE)0101
Sodium/hydrogen exchanger 9B20101
Sodium/glucose cotransporter 1 0101
Protein kinase C alpha type0101
Proto-oncogene vav0011
Protein kinase C delta type0112
Chain A, phosphoenolpyruvate carboxykinase, cytosolic0101
Chain A, Phosphoenolpyruvate Carboxykinase, Cytosolic0101
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]0101
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)0101
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)0101
Chain A, Beta-arrestin 10011
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59F0101
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59F0101
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59F0101
Chain A, PHOSPHOTIDYLINOSITOL 3 KINASE 59F0101
Complement C1s subcomponent0101
CDGSH iron-sulfur domain-containing protein 10202
CDGSH iron-sulfur domain-containing protein 20202
Transforming growth factor beta-1 proprotein0101
Mothers against decapentaplegic homolog 3 0101
Free fatty acid receptor 30033
C-X-C chemokine receptor type 40101
Atypical chemokine receptor 30011
C-X-C chemokine receptor type 40204
dual specificity mitogen-activated protein kinase kinase 11001
RAF proto-oncogene serine/threonine-protein kinase isoform b1001
Regulatory protein E20011
Calcium-activated potassium channel subunit alpha-10101
Sterol 14-alpha-demethylase0022
14-alpha sterol demethylase 0022
14-alpha sterol demethylase 0022
Sodium/potassium/calcium exchanger 40112
Sodium/potassium/calcium exchanger 20112
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
Beta-casein0202
Alpha-2A adrenergic receptor0202
luciferase0001
Glutamine synthetase0011
Pannexin-10101
Pannexin-10101
Vascular cell adhesion protein 10101
Histamine H2 receptor0101
Glutamate 5-kinase0001
Free fatty acid receptor 20011
Nuclear receptor subfamily 2 group E member 10033
NADH-cytochrome b5 reductase 3 0101
Thyroid peroxidase0101
Chain A, Protocatechuate 3,4-dioxygenase alpha chain0011
Chain B, Protocatechuate 3,4-dioxygenase beta chain0011
cathepsin L10202
Coproheme decarboxylase0011
Interleukin-50202
Interleukin-50101
Interleukin-5 receptor subunit alpha0202
Puromycin-sensitive aminopeptidase0101
Chain A, PUTRESCINE-BINDING PROTEIN0011
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN0101
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN0101
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN0101
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN0101
S-adenosylmethionine decarboxylase proenzyme0001
Chain A, Mitogen-activated protein kinase 100101
Chain A, Mitogen-activated protein kinase 100101
Chain A, Mitogen-activated protein kinase 100101
Serine/threonine-protein kinase 30033
Trans-sialidase0101
Trans-sialidase0101
Chain A, 2,2-dialkylglycine decarboxylase0011
Thyrotropin releasing hormone degrading enzyme0101
Chain A, dATP pyrophosphohydrolase0101
Chain A, Adenylate cyclase type 50101
Chain B, Adenylate cyclase type 20101
Monocarboxylate transporter 20002
Chain A, APH(2')-Id0101
glucose-6-phosphate dehydrogenase0101
Epoxide hydrolase 1 0101
Aldo-keto reductase family 1 member A10202
ELAV-like protein 10101
Chymotrypsin-C0101
N0101
DNA-directed RNA polymerase subunit alpha0101
DNA-directed RNA polymerase subunit omega0101
DNA-directed RNA polymerase subunit beta'0101
DNA-directed RNA polymerase subunit beta0101
Phospholipase A2, membrane associated0101
Multidrug resistance protein 1a0001
Advanced glycosylation end product-specific receptor0011
Dipeptidyl peptidase 40112
Voltage-gated sodium channel Nav1.5 cardiac isoform 0101
Vascular endothelial growth factor receptor 30202
Vascular endothelial growth factor receptor 20202
Chromaffin granule amine transporter0101
Synaptic vesicular amine transporter0101
Chain A, Bacterial regulatory proteins, tetR family0011
Chain A, Troponin C, slow skeletal and cardiac muscles0011
N1L 0101
Chain A, Cellular retinoic acid-binding protein 20011
Chain A, Cellular retinoic acid-binding protein 20011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Beta-lactoglobulin0011
MSRA protein0101
plectin 10101
Ribonuclease HI0202
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Genome polyprotein0011
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
DNA-directed RNA polymerase subunit beta0101
NH(3)-dependent NAD(+) synthetase0101
DNA-directed RNA polymerase subunit beta0101
Reverse transcriptase 0101
Chain A, HIV-1 PROTEASE0101
Chain B, HIV-1 PROTEASE0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, POL polyprotein0101
Chain B, POL polyprotein0101
Chain A, Endothiapepsin0101
Chain A, Endothiapepsin0101
Chain A, Activated Factor Xa Heavy Chain0101
Suppressor of tumorigenicity 14 protein0101
Bromodomain adjacent to zinc finger domain protein 2B0101
Prostaglandin G/H synthase 20101
Cytochrome c oxidase subunit 10101
Transporter0101
Sodium-dependent serotonin transporter0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0202
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase0202
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Phosphodiesterase 0202
Retina-specific copper amine oxidase0202
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B0202
Thrombin 0011
Transcription factor AP-10202
UDP-galactopyranose mutase0022
UDP-galactopyranose mutase0022
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial0101
Acyl carrier protein, mitochondrial0101
Eukaryotic elongation factor 2 kinase0101
RuvB-like 10202
Low-density lipoprotein receptor0101
Fibronectin0101
Proprotein convertase subtilisin/kexin type 90101
Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI0011
Chain A, Adenine-n6-dna-methyltransferase Taqi0011
Chain A, Histamine N-Methyltransferase0101
Chain A, Histamine N-Methyltransferase0101
Chain A, Modification Methylase Rsri0011
Chain A, Modification Methylase Rsri0011
Chain A, Ermc' Methyltransferase0101
Chain A, Ermc' Rrna Methyltransferase0101
Chain A, Uroporphyrin-III C-methyltransferase0101
Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI0011
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase0011
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase0011
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase0011
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase0011
tRNA (cytosine(38)-C(5))-methyltransferase0112
Protein arginine N-methyltransferase 50112
Histone-lysine N-methyltransferase SUV39H10202
Adenosylhomocysteinase0001
Protein arginine N-methyltransferase 30101
Indolethylamine N-methyltransferase0101
Histone-lysine N-methyltransferase NSD20202
Adenosylhomocysteinase0001
Phenylethanolamine N-methyltransferase0113
rRNA adenine N-6-methyltransferase0101
tRNA (guanine-N(1)-)-methyltransferase0011
Histone-lysine N-methyltransferase SETDB10101
Retinoblastoma-binding protein 50101
tRNA (guanine-N(1)-)-methyltransferase0011
N6-adenosine-methyltransferase catalytic subunit0101
Histone-arginine methyltransferase CARM10101
Histone-lysine N-methyltransferase KMT5C0101
Histone-lysine N-methyltransferase EZH10202
Protein arginine N-methyltransferase 10505
Methylosome protein 500112
Protein dpy-30 homolog0101
Histamine N-methyltransferase0001
Histone-lysine N-methyltransferase SUV39H20101
tRNA (guanine-N(1)-)-methyltransferase0011
N-lysine methyltransferase SMYD20101
Protein arginine N-methyltransferase 70101
Set1/Ash2 histone methyltransferase complex subunit ASH20101
Met repressor 0022
Histone H3K27 methylase0001
S-adenosylmethionine decarboxylase proenzyme0102
Protein-L-isoaspartate(D-aspartate) O-methyltransferase0101
Catechol O-methyltransferase0001
RmtA0202
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
Tyrosine-protein phosphatase YopH0101
Ubiquitin-like domain-containing CTD phosphatase 10101
B-cell CLL/lymphoma 9 protein0202
Cadherin-10101
Catenin beta-10213
Transcription factor 7-like 20101
Chain A, Erk20101
Mitogen-activated protein kinase 20101
Mitogen-activated protein kinase 14 0112
P2X purinoceptor 70101
5-hydroxytryptamine receptor 1F0314
Orexin receptor type 10406
Orexin receptor type 20405
Adenylate cyclase type 60101
Adenylate cyclase type 3 0101
Adenylate cyclase type 90101
D(1) dopamine receptor0101
Adenylate cyclase type 70101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
Histone-lysine N-methyltransferase SMYD30101
Chain A, Porphobilinogen Synthase0101
Chain A, Porphobilinogen Synthase0101
Chain A, Porphobilinogen Synthase0101
Type-1 angiotensin II receptor0101
Transcriptional activator protein LuxR0202
Programmed cell death protein 10101
Programmed cell death 1 ligand 10101
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, POL polyprotein0011
Chain B, POL polyprotein0011
Chain A, Shikimate kinase0011
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Pyruvate kinase PKLR0101
Cholecystokinin receptor type A0101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Peptidyl-prolyl cis-trans isomerase FKBP1B0022
Programmed cell death protein 40011
Serine/threonine-protein kinase mTOR 0101
Kallikrein-10101
Chymotrypsin-like elastase family member 2A0101
Myeloblastin0101
Neutrophil elastase0101
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Platelet-derived growth factor receptor beta0202
Vascular endothelial growth factor receptor 20202
RuvB-like 20112
Chain A, Acetyl-CoA carboxylase 20011
Sulfate anion transporter 10001
C-X-C chemokine receptor type 5 isoform 10101
C-C chemokine receptor type 60101
Endoglycoceramidase II 0001
alternatively spliced Trp40011
5-hydroxytryptamine receptor 1E0101
sphingosine 1-phosphate receptor 30101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 7 0101
D(4) dopamine receptor0101
D(1B) dopamine receptor0101
Chain A, Mineralocorticoid receptor0101
Chain A, Mineralocorticoid receptor0101
Nuclear receptor subfamily 1 group D member 20202
Corticotropin-releasing factor receptor 10101
Thioredoxin glutathione reductase 0101
Chain A, Ribosomal protein S6 kinase alpha-10101
Chain X, Tyrosine-protein kinase Lyn0101
Chain A, Dual specificity protein kinase TTK0011
Chain A, Dual specificity protein kinase TTK0011
Zinc finger protein GLI20202
Thymidine kinase, cytosolic 0104
Mast/stem cell growth factor receptor Kit0101
Platelet-derived growth factor receptor alpha 0101
Bromodomain-containing protein 90011
Bromodomain-containing protein 70011
Chain A, Protein (aspartate Aminotransferase)0011
Chain A, Aspartate Aminotransferase0011
NADP-dependent malic enzyme, mitochondrial0001
Solute carrier family 13 member 30101
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Metallo-beta-lactamase type 20202
ATP-dependent 6-phosphofructokinase0202
Dihydropteroate synthase0101
Protein argonaute-20022
Transcription regulator protein BACH10101
Transcription factor MafK 0101
PSMD14 protein0101
drug resistance protein 20011
TPA: prothrombin0101
72 kDa type IV collagenase isoform 1 preproprotein0101
Complement C50011
D(2) dopamine receptor0101
Carboxypeptidase M0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1B0101
Ectonucleoside triphosphate diphosphohydrolase 20101
Ectonucleoside triphosphate diphosphohydrolase 10101
Dual specificity protein phosphatase 50101
Ectonucleoside triphosphate diphosphohydrolase 80101
Ectonucleoside triphosphate diphosphohydrolase 3 0101
Orexin receptor type 10101
Orexin receptor type 20101
Chain A, Oxysterols receptor LXR-beta0101
Chain A, Oxysterols receptor LXR-beta0101
Nuclear receptor ROR-alpha0314
Oxysterols receptor LXR-beta0011
Oxysterols receptor LXR-beta0011
Nuclear receptor ROR-beta0213
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0202
Splicing factor 3B subunit 30202
cGMP-specific 3',5'-cyclic phosphodiesterase0123
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
C-C chemokine receptor type 30101
C-C chemokine receptor type 20101
Free fatty acid receptor 10011
Kynurenine 3-monooxygenase0202
Chain A, CES1 protein0101
Phospholipase D1 0101
Phospholipase D10101
Emopamil-binding protein-like0202
7-dehydrocholesterol reductase0112
Alpha-1D adrenergic receptor0101
Alpha-1B adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Sodium/bile acid cotransporter0001
Ileal sodium/bile acid cotransporter0001
Ileal sodium/bile acid cotransporter0001
Solute carrier organic anion transporter family member 4A10002
Beta-lactamase0101
Metallo-beta-lactamase L1 type 30101
Beta-lactamase 0101
Cytochrome P450 14alpha-demethylase0011
Dihydroorotate dehydrogenase 0101
Stromal interaction molecule 10101
Chain A, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA0101
Chain A, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA0101
Chain A, Peroxisome proliferator-activated receptor gamma0101
Chain A, Peroxisome proliferator-activated receptor gamma0101
Tetracycline resistance protein, class B0001
Ras guanyl-releasing protein 30011
Solute carrier family 22 member 40001
Solute carrier family 22 member 30001
Solute carrier family 22 member 40001
Chain A, Multidrug-efflux Transporter 1 Regulator Bmrr0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 0101
Chain A, Pyridoxal kinase0101
Chain A, Pyridoxal Kinase0101
Serine palmitoyltransferase 10011
Serine palmitoyltransferase 20101
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
1-deoxy-D-xylulose-5-phosphate synthase0011
1-deoxy-D-xylulose-5-phosphate synthase0011
Chain D, HEAT-LABILE ENTEROTOXIN0101
Chain E, HEAT-LABILE ENTEROTOXIN0101
Chain D, Heat-labile Enterotoxin0101
Chain E, Heat-labile Enterotoxin0101
Chain A, Galectin-10011
Chain A, Galectin-10011
Galectin-20011
Galectin-10011
Galectin-40011
Chain A, BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I0011
Chain A, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 10011
Chain A, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 10011
Chain B, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 10011
3-oxoacyl-[acyl-carrier-protein] synthase 10101
3-oxoacyl-[acyl-carrier-protein] synthase 30101
3-oxoacyl-[acyl-carrier-protein] synthase 20101
3-oxoacyl-[acyl-carrier-protein] synthase 20011
Urease subunit alpha0101
Urease subunit beta 0101
Thymidine kinase 0204
Thymidine kinase0103
Thymidine phosphorylase0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain B, Odorant-binding Protein0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
Malate dehydrogenase, mitochondrial0101
Monocarboxylate transporter 80001
Solute carrier organic anion transporter family member 1C10001
P2Y purinoceptor 130101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase0101
Chain A, Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
Tyrosine-protein kinase JAK20101
Tyrosine-protein kinase JAK30101
Chain A, Carbonic anhydrase 10101
Carbonic anhydrase 20101
Intermediate conductance calcium-activated potassium channel protein 40101
MSH0001
Cytochrome P450 4B10101
Cytochrome P450 2A70101
Cytochrome P450 2F10101
Cytochrome P450 2C180101
Cytochrome P450 4F80101
Cytochrome P450 4A110101
Cytochrome P450 4F30101
Cytochrome P450 4A220101
Vitamin D 25-hydroxylase0101
Cytochrome P450 2U10101
Cytochrome P450 2W10101
Cytochrome P450 2S10101
Cytochrome P450 3A43 0101
REST corepressor 30101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose0101
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose0101
Trehalose-phosphatase0101
Chain A, Nuclear Receptor ROR-beta0101
Janus kinase 2 (a protein tyrosine kinase)0101
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain A, Histone deacetylase 7a0101
Chain A, Histone deacetylase 7a0101
Histone deacetylase 0101
unnamed protein product0001
Histone deacetylase 10202
Histone deacetylase 30101
Histone deacetylase 20101
Histone deacetylase 10101
Histone deacetylase 0101
Histone deacetylase 40101
Polyamine deacetylase HDAC100101
Histone deacetylase 30101
Histone deacetylase 70101
Histone deacetylase 80101
Histone deacetylase 110101
HD2 type histone deacetylase HDA106 0202
Histone deacetylase 90101
Histone deacetylase 70101
Histone deacetylase 6 0101
Histone deacetylase 40101
Histone deacetylase 60101
Histone deacetylase 50101
Histone deacetylase 0101
NLRP3 protein0101
Epoxide hydrolase B0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, enoyl-acyl carrier reductase0101
Chain C, enoyl-acyl carrier reductase0101
Chain A, Repressor0011
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI0202
Enoyl-acyl carrier reductase0101
Enoyl-ACP reductase II 0101
Thialysine N-epsilon-acetyltransferase0001
Forkhead box protein M10202
Chain A, CARBONIC ANHYDRASE II0101
5-hydroxytryptamine receptor 4 0001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Tryprostatin B synthase0001
Free fatty acid receptor 40011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Hemagglutinin0022
Chain A, Uracil-DNA Glycosylase0101
Coagulation factor XIII A chain0101
Fatty-acid amide hydrolase 20101
Chain A, Cytidine Deaminase0101
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit0101
Seminal ribonuclease0101
P2Y purinoceptor 140033
P2Y purinoceptor 60011
Beta-1,4-galactosyltransferase 1 0001
N-acetyllactosaminide alpha-1,3-galactosyltransferase0001
Chain A, orotidine 5'-monophosphate decarboxylase0101
Chain B, orotidine 5'-monophosphate decarboxylase0101
Chain A, orotidine 5'-monophosphate decarboxylase0101
Chain A, orotidine monophosphate decarboxylase0101
Chain A, orotidine monophosphate decarboxylase0101
Chain B, orotidine monophosphate decarboxylase0101
Chain B, PyrR bifunctional protein0011
Orotidine 5'-phosphate decarboxylase0101
Uridine 5'-monophosphate synthase0101
Orotidine 5'-phosphate decarboxylase 0101
Basic phospholipase A2 10101
Basic phospholipase A2 PLA-A0101
Acidic phospholipase A2 EC-I0101
Ubiquitin carboxyl-terminal hydrolase 470101
Sentrin-specific protease 10101
Valacyclovir hydrolase0001
Chain A, Arginase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
D-alanyl-D-alanine dipeptidase0101
Protein mono-ADP-ribosyltransferase PARP140202
Glycoprotein0101
Adenosylhomocysteinase0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
Arachidonate 5-lipoxygenase0101
Telomere resolvase ResT0101
ADP-ribosylation factor GTPase-activating protein 10101
Chain A, Tankyrase-20011
Chain A, Tankyrase-10101
Chain A, Tankyrase-10101
Protein Wnt-3a0101
Protein Wnt-3a0101
Protein mono-ADP-ribosyltransferase PARP110101
Axin-20011
GH-releasing peptide receptor 0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Alkaline phosphatase, tissue-nonspecific isozyme 0101
PTK2B protein tyrosine kinase 2 beta0101
Ectonucleoside triphosphate diphosphohydrolase 10001
Tumor necrosis factor ligand superfamily member 110101
Chain A, Human Adenosine A2A receptor/T4 lysozyme chimera0011
Chain A, Adenosine receptor A2a0011
Chain A, Adenosine receptor A2a0011
Hexokinase-40101
Butyrophilin subfamily 3 member A10012
Farnesyl diphosphate synthase0101
H0101
Amine oxidase [flavin-containing]0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]