Any drug that enhances the activity of the central nervous system.
| Member | Definition | Class |
|---|
| 1,7-dimethylxanthine | A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals. | 1,7-dimethylxanthine |
| 8-chlorotheophylline | 1,3-Dimethylxanthine in which the hydrogen at position 8 is substituted by chlorine. | 8-chlorotheophylline |
| almitrine | A triamino-1,3,5-triazine compound having allylamino substituents at the 2- and 4-positions and a 4-(bis(p-fluorophenyl)methyl)-1-piperazinyl group at the 6-position. | almitrine |
| almitrine dimesylate | The dimethanesulfonate salt of almitrine. | almitrine dimesylate |
| armodafinil | A 2-[(diphenylmethyl)sulfinyl]acetamide that has R configuration at the sulfur atom. Like its racemate, modafinil, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. Peak concentration in the blood later occurs later following administration than with modafinil, so it is thought that armodafinil may be more effective than modafinil in treating people with excessive daytime sleepiness. | armodafinil |
| benzydamine | A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties. | benzydamine |
| bicuculline | A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species. | bicuculline |
| caffeine | A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee. | caffeine |
| cathinone | The S stereoisomer of 2-aminopropiophenone. | cathinone |
| cgs 15943 | A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors. | 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine; CGS 15943 |
| cocaine | A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. | cocaine |
| cocaine hydrochloride | The hydrochloride salt of cocaine. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. | cocaine hydrochloride |
| doxapram | A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering. | doxapram |
| doxapram hydrochloride | The hydrochloride salt of doxapram. A central and respiratory stimulant with a brief duration of action, both doxapram hydrochloride and its hydrate are used as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering. | doxapram hydrochloride (anhydrous) |
| methamphetamine | A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent. | methamphetamine |
| norpseudoephedrine | An amphetamine that is propylbenzene substituted by a hydroxy group at position 1 and by an amino group at position 2 (the 1S,2S-stereoisomer). | cathine |
| pemoline | A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted by an amino group at position 2 and by a phenyl group at position 5. A central nervous system stimulant, it was used to treat hyperactivity disorders in children, but withdrawn from use following reports of serious hepatotoxicity. | pemoline |
| phentermine | | phentermine |
| tenocyclidine | A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and thiophen-2-yl groups attached at position 1. A dissociative anaesthetic drug with halluccinogenic and stimulant effects. Its effects are similar to those of phencyclidine (PCP, an analogue with the thienyl group replaced by phenyl), but it is rather more potent. | tenocyclidine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 21.3313 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 32.1362 | 7 | 9 |
| arylsulfatase A | Homo sapiens (human) | Potency | 2.3934 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.7957 | 2 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 42.5615 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 4.7755 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.6310 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 15.8489 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 14.2175 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 78.7677 | 2 | 3 |
| CREB-binding protein | Homo sapiens (human) | Potency | 10.5785 | 3 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 13.6368 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 10.2663 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 23.8770 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.5758 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 3.8046 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 18.4927 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 0.5957 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 11.9173 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 10.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 42.4603 | 6 | 9 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 17.7280 | 7 | 11 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 7.5021 | 1 | 7 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 22.1430 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 23.8770 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 4.1807 | 3 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.0593 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 42.8000 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 0.0178 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 33.5157 | 1 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 24.0094 | 2 | 5 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 19.9683 | 1 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 65.8114 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 5.6607 | 2 | 4 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 40.3973 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.6201 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 4.9494 | 1 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.0593 | 2 | 4 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.0355 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 35.4813 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 1.4581 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 11.6906 | 2 | 4 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 8.1411 | 1 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 35.3657 | 2 | 4 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 5.4897 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 61.4272 | 1 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 89.1251 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 15.7202 | 2 | 4 |
| progesterone receptor | Homo sapiens (human) | Potency | 2.9849 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 11.7545 | 2 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.4189 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 69.4275 | 2 | 3 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 19.7349 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 13.0099 | 3 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 40.3973 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 11.2202 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.2069 | 2 | 7 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 31.2784 | 2 | 5 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 18.7232 | 2 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0010 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 25.0820 | 5 | 5 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 21.7213 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 1.8996 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 33.5157 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 7.2500 | 1 | 1 |
| Acidic mammalian chitinase | Homo sapiens (human) | IC50 | 2,500.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 75.6687 | 2 | 3 |
| Adenosine receptor A1 | Cavia porcellus (domestic guinea pig) | Ki | 83.3350 | 5 | 6 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 31.2652 | 17 | 17 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 31.0154 | 35 | 40 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 10.2420 | 2 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 28.6379 | 2 | 11 |
| Adenosine receptor A2a | Cavia porcellus (domestic guinea pig) | Ki | 50.0000 | 3 | 3 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 11.0425 | 36 | 39 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 130.5517 | 31 | 37 |
| Adenosine receptor A2b | Homo sapiens (human) | IC50 | 0.6304 | 2 | 2 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | IC50 | 31.5014 | 1 | 10 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 20.3143 | 23 | 25 |
| Adenosine receptor A2b | Mus musculus (house mouse) | Ki | 23.0000 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 35.3050 | 15 | 20 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.4060 | 1 | 1 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | IC50 | 0.0607 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 16.9678 | 30 | 30 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 56.6667 | 6 | 6 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | Ki | 550.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 3,700.0000 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 270.0000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.3380 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 350.2500 | 3 | 4 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 14,000.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 747.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 28,500.0000 | 1 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 28,500.0000 | 1 | 2 |
| Casein kinase I isoform alpha | Homo sapiens (human) | IC50 | 0.8200 | 1 | 1 |
| Casein kinase I isoform delta | Homo sapiens (human) | IC50 | 0.2400 | 1 | 1 |
| Casein kinase I isoform epsilon | Homo sapiens (human) | IC50 | 0.4900 | 1 | 1 |
| Chain A, Chitinase | Clonostachys rosea | Ki | 19,700.0000 | 1 | 1 |
| Chain A, Endochitinase | Saccharomyces cerevisiae (brewer's yeast) | Ki | 600.0000 | 1 | 3 |
| Chain A, Glycogen Phosphorylase | Oryctolagus cuniculus (rabbit) | Ki | 100.0000 | 1 | 1 |
| Chitotriosidase-1 | Homo sapiens (human) | IC50 | 363.0000 | 1 | 2 |
| Cholinesterase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 0.0044 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| D | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.0021 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.3300 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 39.0000 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0004 | 1 | 1 |
| DNA-dependent protein kinase catalytic subunit | Homo sapiens (human) | IC50 | 5,000.0700 | 2 | 2 |
| Endochitinase | Saccharomyces cerevisiae S288C | Ki | 340.0000 | 1 | 1 |
| Endochitinase A1 | Aspergillus fumigatus | IC50 | 410.0000 | 1 | 1 |
| Endochitinase B1 | Aspergillus fumigatus | IC50 | 363.0000 | 1 | 2 |
| Fatty acid-binding protein, heart | Homo sapiens (human) | IC50 | 0.3670 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Glycogen phosphorylase, liver form | Rattus norvegicus (Norway rat) | IC50 | 648.0000 | 1 | 1 |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | IC50 | 159.1933 | 13 | 15 |
| Glycogen phosphorylase, muscle form | Rattus norvegicus (Norway rat) | IC50 | 182.0000 | 1 | 1 |
| Guanine deaminase | Homo sapiens (human) | Ki | 10.2000 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0004 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 1.9300 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 61.3985 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Sus scrofa (pig) | Ki | 0.2344 | 1 | 1 |
| Palmitoleoyl-protein carboxylesterase NOTUM | Homo sapiens (human) | IC50 | 18.6000 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | Ki | 3,700.0000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 1.2800 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Homo sapiens (human) | IC50 | 8.4800 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Homo sapiens (human) | IC50 | 0.9700 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | IC50 | 1,815.0550 | 2 | 2 |
| Phosphodiesterase | Rattus norvegicus (Norway rat) | IC50 | 70.0000 | 1 | 1 |
| Potassium channel subfamily K member 3 | Rattus norvegicus (Norway rat) | IC50 | 0.4100 | 1 | 1 |
| Potassium channel subfamily K member 9 | Rattus norvegicus (Norway rat) | IC50 | 26.5000 | 2 | 2 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 5.5410 | 6 | 6 |
| Renin | Homo sapiens (human) | Ki | 15.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 100.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 100.0000 | 1 | 1 |
| Serine-protein kinase ATM | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Serine/threonine-protein kinase ATR | Homo sapiens (human) | IC50 | 1,100.0000 | 1 | 1 |
| Serine/threonine-protein kinase mTOR | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.0500 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2400 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 8.5750 | 2 | 2 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 1.3496 | 47 | 67 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | Ki | 0.8500 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 25.2495 | 26 | 41 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.5335 | 39 | 39 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.4232 | 32 | 36 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 8.2885 | 24 | 24 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.6383 | 32 | 34 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 10.1882 | 24 | 24 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.8885 | 15 | 18 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.3634 | 33 | 36 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.5433 | 19 | 28 |
| Solute carrier family 22 member 3 | Rattus norvegicus (Norway rat) | IC50 | 248.0000 | 1 | 1 |
| Synaptic vesicular amine transporter | Rattus norvegicus (Norway rat) | Ki | 41.2800 | 2 | 2 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 3.2277 | 13 | 15 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 2.3415 | 16 | 19 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | Ki | 0.4900 | 1 | 1 |