An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of squalene monooxygenase (EC 1.14.13.132).
| Member | Definition | Class |
|---|
| butenafine | Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections. | butenafine |
| loceryl | A member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections. | amorolfine |
| naftifine | A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections. | naftifine |
| terbinafine | A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections. | terbinafine |
| terbinafine hydrochloride | A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride. | terbinafine hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 13.1530 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 28.3687 | 6 | 6 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 20.1887 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.0112 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 20.9646 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 1.6851 | 1 | 3 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 18.0321 | 2 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 29.2153 | 6 | 6 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 25.7565 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 18.8322 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 23.4850 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 20.9646 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 15.9447 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 26.6032 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.3161 | 2 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 25.1189 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 55.5628 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 20.9646 | 1 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 26.8325 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 20.9646 | 1 | 6 |
| Interferon beta | Homo sapiens (human) | Potency | 20.9646 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 9.9842 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 31.6505 | 2 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 18.4496 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.8741 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 12.0305 | 3 | 5 |
| Parkin | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 20.3148 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 28.7017 | 2 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| polyprotein | Zika virus | Potency | 23.4850 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 11.0406 | 1 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 14.0966 | 2 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 31.0396 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 21.5756 | 3 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 9.0859 | 2 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 31.3349 | 2 | 8 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.6916 | 2 | 6 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 29.8493 | 2 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 42.1668 | 2 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 15.2180 | 2 | 5 |