Page last updated: 2024-08-05 14:40:30
EC 1.9.3.1 (cytochrome c oxidase) inhibitor
An EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor that interferes with the action of cytochrome c oxidase (EC 1.9.3.1).
ChEBI ID: 38500
Members (3)
Member | Definition | Class |
---|---|---|
carbon monoxide | A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas. | carbon monoxide |
cyanides | A pseudohalide anion that is the conjugate base of hydrogen cyanide. | cyanide |
potassium cyanide | A cyanide salt containing equal numbers of potassium cations and cyanide anions. | potassium cyanide |
Research
Studies (30,861)
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 14,481 (46.92) | 18.7374 |
1990's | 3,383 (10.96) | 18.2507 |
2000's | 5,553 (17.99) | 29.6817 |
2010's | 5,998 (19.44) | 24.3611 |
2020's | 1,446 (4.69) | 2.80 |
Study Types
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 715 (2.14%) | 5.53% |
Reviews | 1,781 (5.33%) | 6.00% |
Case Studies | 492 (1.47%) | 4.05% |
Observational | 73 (0.22%) | 0.25% |
Other | 30,336 (90.83%) | 84.16% |
Protein Targets (6)
Inhibition Measurements
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Carbonic anhydrase | Methanosarcina thermophila | Ki | 8,400.0000 | 1 | 1 |
Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 160.0800 | 2 | 5 |
Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 199.9750 | 1 | 4 |
Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 163.9800 | 2 | 5 |
Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 199.9750 | 1 | 4 |
Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 24.0000 | 1 | 1 |