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2,5-diketopiperazines
Any piperazinone that has a piperazine-2,5-dione skeleton.
ChEBI ID: 65061
Members (13)
| Member | Definition | Role |
|---|---|---|
| 2,5-dioxopiperazine | A cyclic peptide that is piperazine in which the hydrogens at positions 2 and 5 are replaced by oxo groups. | piperazine-2,5-dione |
| albonoursin | A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which the two hydrogen at position 3 and those at position 6 are replaced by benzylidene and isobutylidene groups (the 3Z,6Z-geoisomer). | albonoursin |
| cyclo(L-tryptophyl-L-alanyl) | cyclo(L-tryptophyl-L-alanyl) | |
| cyclo(leucyl-phenylalanyl) | A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which one hydrogen at position 3 and one hydrogen at position 6 are replaced by benzyl and isobutyl groups (the 3S,6S-diastereomer). | cyclo(L-phenylalanyl-L-leucyl) |
| cyclo(phenylalanyl-phenylalanyl) | A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which one hydrogen at position 3 and one hydrogen at position 6 are replaced by benzyl groups (the 3S,6S-diastereomer). | cyclo(L-phenylalanyl-L-phenylalanyl) |
| cyclo(tyrosyl-tyrosyl) | A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione in which one hydrogen at position 3 and one hydrogen at position 6 are replaced by p-hydroxybenzyl groups. | cyclo(tyrosyl-tyrosyl) |
| echinuline | An indole alkaloid with formula C29H39N3O2. It is a fungal metabolite found in several Aspergillus species. | echinulin |
| mycocyclosin | An organic heterotetracyclic compound obtained via intramolecular oxidative aromatic coupling of cyclo(L-tyrosyl-L-tyrosyl). | mycocyclosin |
| n(alpha)-acetylfusarinines | A member of the class of 2,5-diketopiperazines that is 2,5-diketopiperazine which is substituted at positions 3 and 6 by 3-(hydroxyamino)propyl groups in which the nitrogens have been acylated by (2E)-5-hydroxy-3-methylpent-2-enoyl groups. The substituent at position 3 has been further modified by having its terminal hydroxy group esterified by condensation with the carboxy group of N(2)-acetyl-N(5)-hydroxy-L-ornithine in which the N(5) nitrogen has been acylated by a (2E)-5-hydroxy-3-methylpent-2-enoyl group. | desferricoprogen |
| npi 2358 | A member of the class of 2,5-diketopiperazines that is piperazine-2,5-dione substituted by benzylidene and (5-tert-butyl-1H-imidazol-4-yl)methylidene groups at positions 3 and 6, respectively. It is a vascular disrupting agent and a microtubule destabalising agent which was in clinical trials (now discontinued) for the treatment of non-small cell lung cancer. | plinabulin |
| preechinulin | preechinulin | |
| rhodotorulic acid | A member of the class of 2,5-diketopiperazines obtained by cyclodimerisation of N(5)-acetyl-N(5)-hydroxy-L-ornithine. | rhodotorulic acid |
| tardioxopiperazine a | tardioxopiperazine A |
Research
Studies (176)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 27 (15.34) | 18.7374 |
| 1990's | 13 (7.39) | 18.2507 |
| 2000's | 23 (13.07) | 29.6817 |
| 2010's | 81 (46.02) | 24.3611 |
| 2020's | 32 (18.18) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 6 (3.11%) | 5.53% |
| Reviews | 13 (6.74%) | 6.00% |
| Case Studies | 1 (0.52%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 173 (89.64%) | 84.16% |