A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
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| "Primary hyperparathyroidism is the leading cause of hypercalcemia in the United States." | ( Chen, H; Ibele, A; Kabbani, L; Murphy, J; Weigel, TL, 2005) |
| "When a diagnosis of primary hyperparathyroidism is made but the localization of adenoma(s) is not identified, the patient should be referred to specialists for parathyroid surgery." | ( Sato, K, 2005) |
| "Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass." | ( Kuo, SW; Lee, IT; Pei, D; Sheu, WH; Tu, ST, 2006) |
| "Primary hyperparathyroidism is the most common cause of hypercalcemia in the outpatient setting and is typically caused by a single benign parathyroid adenoma." | ( Farford, B; Moraghan, TJ; Presutti, RJ, 2007) |
| "Primary hyperparathyroidism is a rare cause of chronic pancreatitis and there is a paucity of data on this interesting association." | ( Bhadada, SK; Bhansali, A; Bhasin, DK; Rana, SS; Sinha, SK; Udawat, HP, 2008) |
| "Sporadic primary hyperparathyroidism is due to single adenoma in over 90-95% of instances." | ( Membrilla, E; Rosa, P; Sancho, JJ; Sitges-Serra, A; Valero, M, 2008) |
| "Primary hyperparathyroidism is a curable cause of a Creutzfeldt-Jakob like syndrome." | ( Chadenat, ML; D'Anglejean, J; Dalloz, MA; Fineyre, F; Pico, F, 2009) |
| "Primary hyperparathyroidism is a rare but potentially life-threatening side effect of long-term lithium therapy." | ( Perrier, ND; Rizwan, MM, 2009) |
| "Most patients with primary hyperparathyroidism are asymptomatic, and the focus of the presentation may be the side effects of chronic hypercalcemia, osteoporosis, renal lithiasis, peptic ulcer disease, and hypertension." | ( Dora, JM; Maia, AL; Meyer, EL; Puñales, MK; Siqueira, DR, 2008) |
| "Primary hyperparathyroidism is a common cause of hypercalcemia with resulting hypercalciuria and a subset of these patients with primary hyperparathyroidism present with urolithiasis." | ( Berger, AD; Cooperberg, MR; Duh, QY; Eisner, BH; Stoller, ML; Wu, W, 2009) |
| "Primary hyperparathyroidism is nowadays frequently diagnosed from screening biological work-up: it is due to a single parathyroid adenoma in nearly 90% of cases." | ( Richard, B, 2009) |
| "Primary hyperparathyroidism is an important factor in the development of electrocardiographic abnormalities in this population, some of which are not corrected after parathyroidectomy." | ( Asensio-Lafuente, E; Castillo-Martínez, L; Orea-Tejeda, A; Orozco-Gutiérrez, JJ; Rebollar-González, V; Reza-Albarrán, A; Silva-Tinoco, R; Vázquez-Díaz, O, 2009) |
| "Primary hyperparathyroidism is the third most common endocrine disorder, with the highest incidence in postmenopausal women." | ( Fraser, WD, 2009) |
| "Primary hyperparathyroidism is caused by an adenoma/hyperplasia in the parathyroid glands in which hypercalcemia is mainly due to an increased secretion of parathormone (PTH)." | ( Alameda Hernando, C; Díaz Guardiola, P; Guijarro de Armas, G; Iglesias Bolaños, P; Pavón de Paz, I; Vega Piñero, B, 2009) |
| "Primary hyperparathyroidism is a common cause of hypercalcemia in dogs." | ( Goldstein, RE; Schaefer, C, 2009) |
| "Primary hyperparathyroidism is associated with an increased cardiovascular morbidity and mortality." | ( Alrasheedi, S; Ayav, A; Bresler, L; Brunaud, L; Caillard, C; Germain, A; Mirallie, E; Rancier, M; Weryha, G; Zarnegar, R, 2009) |
| "Primary hyperparathyroidism is commonly due to a single, sporadic parathyroid adenoma, and surgery is considered the treatment of choice based on guidelines established by the National Institutes of Health consensus panel." | ( Padmanabhan, H, 2010) |
| "Primary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH)." | ( Agha, A; Davenport, C, 2009) |
| "Primary hyperparathyroidism is a common disorder of mineral metabolism characterized by incompletely regulated, excessive secretion of parathyroid hormone from one or more of the parathyroid glands." | ( Bilezikian, JP; Silverberg, SJ, 2010) |
| "Primary hyperparathyroidism is the most common cause of hypercalcemia in the outpatient setting." | ( Felger, EA; Kandil, E, 2010) |
| "Primary hyperparathyroidism is one of the most common causes of hypercalcemia." | ( Chang, YC; Cheng, SP; Doherty, GM; Liu, CL, 2011) |
| "Primary hyperparathyroidism is a common endocrine disease." | ( Quinkler, M; Ventz, M, 2010) |
| "Primary hyperparathyroidism is rare in children." | ( Carpenter, TO; Cheng, DW; Udelsman, RD; Vanstone, MB, 2011) |
| "Main message Primary hyperparathyroidism is the most common cause of hypercalcemia in outpatients." | ( Khan, A; Pallan, S, 2011) |
| "Primary hyperparathyroidism is systemic, polymorphic disease." | ( Adamkiewicz, K; Mazur, J; Podwińska, E; Skorupa, A; Turek, S; Ziółko, E, 2011) |
| "Patients with primary hyperparathyroidism are eligible for outpatient surgery if the risk of conducting the operation is low and various imaging techniques have confirmed the location of the parathyroid adenoma." | ( de Herder, WW; Geilvoet, W; van Eijck, CH; van Ginhoven, TM, 2012) |
| "Normocalcemic primary hyperparathyroidism is at present one of the most common reasons for consultation in bone metabolism units." | ( Guadalix Iglesias, S; Hawkins Carranza, F; Martínez Díaz-Guerra, G, 2013) |
| "Normocalcemic primary hyperparathyroidism is typically identified after referral to a specialty clinic." | ( Bauer, DC; Bilezikian, JP; Cremers, SC; Cusano, NE; Haney, EM; Maalouf, NM; Orwoll, ES; Wang, PY; Zhang, C, 2013) |
| "Sixteen percent of primary hyperparathyroidism is caused by ectopic parathyroid glands." | ( Kajdácsi, Z; Mészáros, L; Révai, T; Tóth, M; Vadász, P, 2013) |
| "Primary hyperparathyroidism is a rare cause of acute pancreatitis." | ( Abraham, D; Augustine, J; Chandramohan, A; Chowdhury, SD; Dutta, AK; Hephzibah, J; Jeyaraj, V; Joseph, AJ; Kurien, RT; Pal, S; Simon, EG, 2014) |
| "Primary hyperparathyroidism is a common endocrinopathy which is nowadays diagnosed incidentally." | ( Antonucci, G; Catrambone, U; Foppiani, L; Lione, S; Lo Pinto, G; Marinaro, E; Piccardo, A; Scirocco, MC, 2014) |
| "Primary hyperparathyroidism is characterised by high parathyroid hormone (PTH) levels and concomitant hypercalcaemia." | ( Musters, L; Smit, C; van Ginhoven, TM, 2014) |
| "Primary hyperparathyroidism is a complex disease process that requires careful diagnosis and thoughtful medical and surgical management." | ( Callender, GG; Udelsman, R, 2014) |
| "Primary hyperparathyroidism is a common endocrine disorder which is diagnosed biochemically and for which therapy is surgical." | ( Fettich, J; Hocevar, M; Kocjan, T; Lezaic, L; Rep, S; Sever, MJ, 2014) |
| "Primary hyperparathyroidism is the main endocrinopathy associated with Multiple Endocrine Neoplasia type 1 syndrome." | ( Brandi, ML; Cianferotti, L; Cioppi, F; Colao, A; Faggiano, A; Ferolla, P; Giusti, F; Gronchi, G; Masi, L, 2016) |
| "Primary hyperparathyroidism is well known to be associated with cardiovascular morbidity and mortality." | ( Altuntas, Y; Canat, MM; Dogan Cakir, S; Erol, S; Karatas, S; Kuzu, I; Yener Ozturk, F, 2016) |
| "Primary hyperparathyroidism is a medical condition caused by overactive of parathyroid gland." | ( Harbuwono, DS; Larasati, D; Pramono, LA; Soebardi, S; Yossy, Y, 2015) |
| "Primary hyperparathyroidism is a rare disease characterized by excessive secretion of parathyroid hormone from parathyroid adenoma, hyperplasia, or malignancy." | ( Hayashi, S; Ishibashi, K; Kitada, M; Nana, T; Okazaki, S; Yasuda, S, 2016) |
| "Primary hyperparathyroidism is a disease with increased cell proliferation and enhanced PTH secretion due to the escape from negative feedback by calcium ion in parathyroid cells for their tumorization." | ( Kaji, H, 2016) |
| "Primary hyperparathyroidism is a common endocrine disorder that results in elevated levels of parathyroid hormone and subsequent hypercalcaemia." | ( Walker, J, 2016) |
| "Primary hyperparathyroidism is the most common manifestation of multiple endocrine neoplasia type 1 (MEN1)." | ( Beninato, T; Drake, FT; Duh, QY; Gosnell, J; Kluijfhout, WP; Liu, C; Shen, WT; Suh, I; Vriens, MR, 2016) |
| "Patients with primary hyperparathyroidism are characterized by increased calcium plasma concentrations, which in turn could have a potential to induce ECG changes, especially shortening of the QT interval." | ( Dokupilova, A; Payer, J, 2016) |
| "Primary hyperparathyroidism is characterized by increased levels of serum calcium and parathyroid hormone." | ( Allendorf, JD; Bubis, L; Chabot, JA; Epelboym, I; Herman, MC; Kuo, JH; Lee, JA; Lim, JY, 2017) |
| "Primary hyperparathyroidism is primarily due to a solitary parathyroid adenoma but multi-gland disease, parathyroid carcinoma, and ectopic parathyroid hormone production can occur." | ( Arnold, A, 2016) |
| "Juvenile primary hyperparathyroidism is uncommon and more symptomatic than the adult counterpart." | ( Borsari, S; Cacciatore, F; Cetani, F; Marcocci, C; Materazzi, G; Miccoli, M; Miccoli, P; Pardi, E; Saponaro, F, 2018) |
| "Primary hyperparathyroidism is a disease that occurs more frequently than generally thought and is often overlooked." | ( Nies, C, 2017) |
| "Primary hyperparathyroidism is caused by single gland disease in 85% of cases and by multiglandular disease in 15%." | ( Albarano, A; Carty, SE; Ghodadra, AG; Hiremath, TG; Joyce, JM; McCoy, KL; Muthukrishnan, A; Yip, L, 2018) |
| "Primary hyperparathyroidism is overlooked and underdiagnosed in a number of patients in the clinical setting." | ( Bayadsi, H; Enell, J; Hennings, J; Lundgren, E, 2018) |
| "Primary hyperparathyroidism is commonly caused by excess production of parathyroid hormone from sporadic parathyroid adenomas." | ( Fan, YB; Fu, WZ; He, JW; Sun, B; Wang, ZP; Wei, Z; Zhang, ZL, 2018) |
| "Patients with primary hyperparathyroidism are at risk for skeletal and renal end-organ damage." | ( Adams, AL; Assadipour, Y; Haigh, PI; Kuo, EJ; Yeh, MW; Zhou, H, 2019) |
| "Primary hyperparathyroidism is a relatively common condition affecting calcium homoeostasis, in which MPC can rarely occur." | ( Kamalanathan, S; Lakshmana Perumal, N; Sahoo, JP; Selvi, J, 2019) |
| "Primary hyperparathyroidism is mostly asymptomatic and does not affect conception or pregnancy." | ( Leere, JS; Vestergaard, P, 2019) |
| "Primary hyperparathyroidism is often associated with non-disease-specific symptoms." | ( Bränström, R; Koman, A; Nilsson, IL; Ohlsson, S; Pernow, Y, 2019) |
| "Primary hyperparathyroidism is associated with an increased cardiovascular mortality, but mechanisms underlying this association are unclear." | ( Bihain, F; Brunaud, L; Croise-Laurent, V; Demarquet, L; Koubaity, O; Mandry, D; Nguyen-Thi, PL; Nomine-Criqui, C, 2020) |
| "Background Primary hyperparathyroidism is the third most common endocrine disorder for which surgical procedure called parathyroidectomy is the most effective treatment." | ( Hocevar, M; Majcen, M, 2020) |
| "Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect." | ( Aschenbach, R; Biermann, A; Freesmeyer, M; Kloos, C; Lupp, A; Mtuka-Pardon, G; Seifert, P; Werner, C; Wolf, G, 2020) |
| "Primary hyperparathyroidism is the most common cause of hypercalcemia." | ( Kamejima, S; Kobayashi, A; Nakashima, A; Ohkido, I; Uchiyama, T; Yamamoto, I; Yokoo, T, 2021) |
| "Normocalcaemic primary hyperparathyroidism is a condition that can present with intermittent hypercalcemia or may evolve into hypercalcemic primary hyperparathyroidism." | ( Dawood, NB; Leung, AM; Livhits, MJ; Shieh, A; Yan, KL; Yeh, MW, 2020) |
| "Primary hyperparathyroidism is characterised by autonomous production of parathyroid hormone resulting in hypercalcaemia." | ( Castle, C; Tietjens, J, 2021) |
| "Primary hyperparathyroidism is characterized by an autonomous hypersecretion of parathyroid hormone by one or more parathyroid glands." | ( Barale, M; Berton, AM; Bioletto, F; Deandreis, D; Ghigo, E; Parasiliti-Caprino, M; Prencipe, N; Procopio, M, 2021) |
| "Primary hyperparathyroidism is not so uncommon a disease." | ( Jain, A; Khandelwal, N; Silodia, A; Yadav, N; Yadav, SK, 2022) |
| "Primary hyperparathyroidism is a biochemical, not radiologic diagnosis." | ( Brumund, KT; Bykowski, J; Kimura, B; Koo, SJ; McCowen, KC; Nagelberg, J, 2021) |
| "Normocalcemic primary hyperparathyroidism is an entity on which several issues about its clinical management remains unclear." | ( Huguet-Moreno, I; Marazuela Azpiroz, M; Muñoz de Nova, JL; Sampedro-Nuñez, M, 2021) |
| "Primary hyperparathyroidism is caused by uncontrolled and immoderate secretion of parathyroid hormone." | ( Li, C; Zhang, J; Zhu, Y, 2021) |
| "Primary hyperparathyroidism is a common endocrine disorder." | ( Cusano, NE, 2021) |
| "Sporadic primary hyperparathyroidism is a common endocrinopathy, particularly afflicting postmenopausal women and both African American men and women." | ( Kim, SJ; Shoback, DM, 2021) |
| "The primary hyperparathyroidism is a frequent disease whom the surgery is the only curative treatment." | ( Agirre, L; Arana, A; de la Quintana, A; Larrea, J; Martínez, G; Servide, MJ, 2022) |
| "Primary hyperparathyroidism is now largely managed surgically via minimally invasive techniques." | ( Abraham, MN; Abraham, PJ; Chen, H; Lindeman, B, 2023) |
| "Primary hyperparathyroidism is associated with an increased cardiovascular mortality, and its underlying mechanisms remain unclear." | ( Al-Ahmed, F; Al-Jehani, A; Bihain, F; Brunaud, L; Demarquet, L; Guerci, B; Nguyen-Thi, PL; Nomine-Criqui, C; Ziegler, O, 2022) |
| "Primary hyperparathyroidism is the third most common endocrine disease." | ( Arias, A; Garzón, A; Guzmán, L; Olguín Joseau, S; Peretti, E; Ruggieri, M, 2022) |
| "Primary hyperparathyroidism is a safe procedure in terms of morbidity and long-term outcomes." | ( Arias, A; Garzón, A; Guzmán, L; Olguín Joseau, S; Peretti, E; Ruggieri, M, 2022) |
| "Three phenotypes of primary hyperparathyroidism are distinct clinical entities." | ( Armstrong, VL; Butterfield, R; Cronin, PA; Hangge, PT; Norain, A; Stucky, CH; Wasif, N, 2023) |
| "Primary hyperparathyroidism is a common endocrine disease and most cases are asymptomatic." | ( Bestepe, N; Cakir, B; Cuhaci, FN; Ersoy, R; Ogmen, BE; Ozdemir, D; Polat, B, 2022) |
| "Primary hyperparathyroidism is a common endocrine disease and most cases are asymptomatic." | ( Bestepe, N; Cakir, B; Cuhaci, FN; Ersoy, R; Ogmen, BE; Ozdemir, D; Polat, B, 2022) |
| "Normocalcemic primary hyperparathyroidism is a variant of primary hyperparathyroidism with consistently normal albumin-adjusted or free-ionized calcium levels." | ( Chertok Shacham, E; Ishay, A; Lazareva, T; Mahagna, L; Maman, N; Masalha, R; Sela, G, 2023) |
| "Normohormonal primary hyperparathyroidism is a term used to describe patients with a normal PTH and elevated calcium levels." | ( Nabata, KJ; Wiseman, JJ; Wiseman, SM, 2023) |
| "Primary hyperparathyroidism is a common endocrine disorder, with 80% of all cases usually caused by one single hyperfunctioning parathyroid adenoma." | ( Aloj, L; Bashari, WA; Buch, HN; Casey, RT; Challis, BG; Cheow, HK; Chung, TT; Das, T; Fish, B; Gillett, D; Gurnell, M; Harper, I; Huynh, KA; Inchiappa, D; Jani, P; Koulouri, O; MacFarlane, J; Masterson, L; Mendichovszky, IA; Moyle, P; Newman, C; Powlson, AS; Scoffings, D; Simpson, HL; Stokes, VJ, 2023) |