Klinefelter Syndrome

A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.).

Synonym
Klinefelter Syndrome

Excerpt	Reference
"Klinefelter syndrome is the most common chromosomal abnormality in humans."	( Aylstock, M; Graham, JM; Visootsak, J, 2001)
"Klinefelter syndrome is a major cause of infertility in the male."	( Carel, JC; Fennoy, I; Lahlou, N; Roger, M, 2004)
"Klinefelter syndrome is a hypergonadotropic hypogonadism determined by the presence of one or more extra X chromosomes and has an incidence of 1:800 males."	( Lichiardopol, C; Mota, M; Pănuş, C, 2004)
"Klinefelter syndrome is characterized by a vast range of phenotypes related to androgen effects."	( Depenbusch, M; Gromoll, J; Nieschlag, E; Zitzmann, M, 2004)
"The Klinefelter syndrome is characterized by one or more extra X-chromosomes, deficient androgens, increased gonadotropines, fibrosis and hyalinization of the seminiferous tubules, small testes, gynecomastia, disproportionately long legs, sparse facial hair, and diminished sexual activity."	( Glander, HJ, 2005)
"Klinefelter syndrome is the most common sex-chromosome disorder; it affects approximately one in every 660 men."	( Bojesen, A; Gravholt, CH, 2007)
"On the other hand, Klinefelter syndrome is well recognized chromosomal abnormality caused by an additional X chromosome in males (47,XXY), and the characteristic clinical findings include tall stature, immaturity of external genitalia, testicular dysfunction."	( Matsuo, M; Nishiyama, A; Ogino, W; Oka, N; Takeshima, Y; Yagi, M, 2007)
"Klinefelter syndrome is characterized by progressive testicular failure causing androgen deficiency and azoospermia in most patients."	( Aksglaede, L; Juul, A; Jørgensen, N; Skakkebaek, NE, 2009)
"Klinefelter syndrome is the most common chromosomal aneuploidy in men (XXY karyotype, 1 in 600 live births) and results in testicular (infertility and androgen deficiency) and nontesticular (cognitive impairment and osteoporosis) deficits."	( Dunstan, CR; Erkkila, K; Jia, Y; Kalak, R; Liu, PY; Lue, Y; Seibel, MJ; Swerdloff, RS; Wang, C; Zhou, H, 2010)
"XXY men (Klinefelter syndrome) are testosterone deficient, socially isolated, exhibit impaired gender identity, and may experience more homosexual behaviors."	( Abuyounes, D; Erkkila, K; Hikim, AS; Jentsch, JD; Lee, PW; Liu, PY; Lue, Y; Schwarcz, MD; Swerdloff, RS; Wang, C, 2010)
"Klinefelter syndrome is caused by the presence of one or more additional X chromosomes in an affected male."	( Juhn, AT; Levin, AV; Nabi, NU, 2012)
"Klinefelter syndrome is usually characterised by the presence of a eunuchoid body habitus and testes that are usually small and firm, with low testosterone, and elevated luteinising hormone and follicle-stimulating hormone levels, consistent with hypergonadotropic hypogonadism."	( Cherian, KE; Jebasingh, FK; Kapoor, N; Paul, TV, 2015)
"Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction."	( Angelini, S; Caretta, N; Cavalieri, F; Di Grazia, M; Di Mambro, A; Ferlin, A; Foresta, C; Selice, R, 2018)
"Klinefelter syndrome is the most common chromosomal disorder in males and the most common cause of hypergonadotropic hypogonadism."	( Carlomagno, F; Gianfrilli, D; Isidori, AM; Lenzi, A; Minnetti, M; Paparella, R; Pofi, R; Pozza, C; Radicioni, A; Sesti, F; Spaziani, M; Tarani, L; Tarantino, C; Tenuta, M, 2023)

Excerpt	Reference
"Klinefelter syndrome has been associated with thyroid abnormalities, the genesis of which is not yet fully clear."	( Anzuini, A; Granato, S; Lenzi, A; Panimolle, F; Radicioni, AF; Ruga, G; Spaziani, M; Tahani, N, 2017)

Excerpt	Reference
"Klinefelter syndrome, affecting males, is a collection of characteristics that occurs as a result of two or more X chromosomes."	( Crawford, D; Dearmun, A, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	439 (53.34)	23.3326
1990's	66 (8.02)	12.5806
2000's	120 (14.58)	18.1394
2010's	145 (17.62)	28.8240
2020's	53 (6.44)	9.53

Drug	Relationship Strength	Studies	Trials
acetylcarnitine	low	1	0
quinacrine	low	4	0
carnitine	low	2	0
chlorine	low	1	0
salicylic acid	low	1	0
methylmalonic acid	low	1	0
n(g),n(g')-dimethyl-l-arginine	low	2	0
lactic acid	low	1	0
dalteparin	low	1	0
iodine	low	4	0
melatonin	medium	5	1
uric acid	low	1	0
phenytoin	low	1	0
aminoglutethimide	low	1	0
theophylline	low	1	0
amitriptyline	low	1	0
amobarbital	low	1	0
anastrozole	low	4	0
aspirin	low	1	0
azathioprine	low	1	0
carbamazepine	low	1	0
chlorpromazine	medium	2	1
cyclofenil	low	2	0
diazoxide	low	1	0
fluorouracil	low	1	0
gentamicin	low	1	0
haloperidol	low	3	0
hexestrol	low	2	0
avapro	low	1	0
2-propanol	low	3	0
isoproterenol	low	1	0
ketotifen	low	1	0
lansoprazole	low	1	0
letrozole	medium	1	1
metformin	low	1	0
metoprolol	low	1	0
metyrapone	low	4	0
mitotane	low	1	0
omeprazole	low	1	0
phenmetrazine	low	1	0
pioglitazone	low	1	0
pirenzepine	low	1	0
sulfasalazine	low	1	0
thalidomide	low	1	0
tolbutamide	low	1	0
trifluoperazine	low	1	0
mitomycin	low	1	0
prednisolone	low	5	0
estriol	low	5	0
lysergic acid diethylamide	low	2	0
thymidine	low	13	0
floxuridine	low	3	0
hydroxyproline	low	6	0
thyroxine	low	10	0
dextroamphetamine	low	1	0
aldosterone	low	3	0
prednisone	low	2	0
estrone	low	10	0
androsterone	low	11	0
etiocholanolone	low	7	0
triiodothyronine	low	5	0
chloramphenicol	low	1	0
lysine	low	1	0
ethinyl estradiol	medium	6	1
methyltestosterone	low	7	0
adenosine diphosphate	low	1	0
kanamycin a	low	1	0
bromodeoxyuridine	low	4	0
androstenedione	low	7	0
phenylalanine	low	1	0
colchicine	low	2	0
norethindrone	low	1	0
17-alpha-hydroxyprogesterone	low	3	0
cytarabine	low	1	0
valine	low	1	0
mestranol	low	2	0
methandrostenolone	low	1	0
arginine	low	1	0
fluoxymesterone	low	2	0
methylprednisolone	low	2	0
n-vinyl-2-pyrrolidinone	low	1	0
pregnenolone	low	1	0
nafcillin	low	1	0
chlormadinone acetate	low	2	0
testosterone enanthate	medium	16	2
azacitidine	low	1	0
cyproterone acetate	low	1	0
hematoxylin	low	1	0
dihydrotestosterone	medium	15	1
eosine yellowish-(ys)	low	1	0
glycopyrrolate	low	1	0
dehydroepiandrosterone sulfate	low	2	0
testolactone	low	2	0
mesterolone	low	3	0
benperidol	medium	1	1
iodinated glycerol	low	1	0
trolamine salicylate	low	5	0
cetylpyridinium chloride anhydrous	medium	3	1
fludrocortisone	low	1	0
amoxicillin	low	1	0
etoposide	low	5	0
idarubicin	low	1	0
buserelin	low	1	0
ibandronic acid	medium	1	1
6-sulfatoxymelatonin	low	1	0
triazoles	medium	6	1
delphinidin	low	1	0
sertraline	low	1	0
zoledronic acid	low	1	0
17-alpha-hydroxypregnenolone	low	2	0
homocysteine	low	2	0
pregnanetriol	low	8	0
2,3-bis(4-hydroxyphenyl)-propionitrile	low	1	0
n,n-dimethylarginine	low	2	0
lhrh, leu(6)-n-et-glynh2(10)-	low	1	0
cgp 47645	medium	1	1
methotrexate	low	2	0
aminopterin	low	1	0
biotin	low	1	0
angiotensin ii	low	1	0
dabigatran	low	1	0
cortisone	low	2	0
glycogen	low	2	0
inositol 3-phosphate	low	1	0
digitoxin	low	1	0
diethylstilbestrol	low	4	0
isomethyleugenol	low	1	0
stilbenes	low	1	0
enclomiphene	low	18	0
D-fructopyranose	low	6	0
succimer	low	1	0
tamoxifen	medium	8	1
nadp	low	1	0
pica	low	1	0
lithium	low	2	0
quinine	low	1	0
17-ketosteroids	low	53	0
dinoprost	low	1	0
vitamin k semiquinone radical	low	1	0
11-dehydro-thromboxane b2	low	1	0
amphotericin b	low	1	0
8-epi-prostaglandin f2alpha	low	1	0
thromboxane b2	low	1	0
cyproterone	medium	2	1
naloxone	medium	3	2
dexmedetomidine	low	1	0
ramipril	low	1	0
phosphorus	low	1	0
ay 25,205	low	1	0
lhrh, n-et-alanh2(6)-	low	1	0
oxalates	low	1	0
pregnanediol	low	4	0
sq-23377	low	1	0
phosphocreatine	low	1	0
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane	low	1	0
ribose	low	1	0
brimonidine tartrate	low	1	0
losartan potassium	low	2	0
technetium tc 99m exametazime	low	1	0
pituitrin	medium	2	1
acid phosphatase	low	4	0
nad	low	2	0
natriuretic peptide, c-type	low	1	0
cellulose	low	1	0
menotropins	low	6	0
ro13-9904	low	1	0
sodium ethylxanthate	low	10	0
cardiovascular agents	low	1	0
lhrh, phe(2)-trp(3)-phe(6)-	low	1	0
glycolipids	low	1	0
interleukin-8	low	2	0
natriuretic peptide, brain	low	1	0
ascorbic acid	low	2	0
warfarin	low	5	0
phenprocoumon	low	1	0
epidermal growth factor	low	1	0
kiss1 protein, human	low	1	0
vitamin b 12	low	2	0
cyclosporine	low	2	0
technetium tc 99m dimercaptosuccinic acid	low	1	0
guanine	low	1	0
folic acid	low	2	0
clozapine	low	1	0
dacarbazine	low	1	0
olanzapine	low	1	0
allopurinol	low	1	0
azaguanine	low	1	0
sildenafil citrate	low	1	0
cytidylyl-3'-5'-guanosine	low	1	0
eye	low	1	0
ego	low	1	0
leptin	medium	2	1

Protein Targets (1,418)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
aldehyde dehydrogenase 1 family, member A1	35	0	0	35
Chain A, Cruzipain	7	0	0	7
IDH1	27	0	0	27
DNA polymerase iota isoform a (long)	22	0	0	22
geminin	63	0	0	63
Sex hormone-binding globulin	0	1	16	17
acetylcholinesterase	24	0	0	24
pregnane X receptor	12	0	0	12
SMAD family member 2	15	0	0	15
SMAD family member 3	15	0	0	15
TDP1 protein	67	0	0	67
GLI family zinc finger 3	58	0	0	58
Microtubule-associated protein tau	25	0	0	25
AR protein	78	0	0	78
progesterone receptor	45	0	0	45
glucocorticoid receptor [Homo sapiens]	58	0	0	58
retinoic acid nuclear receptor alpha variant 1	57	0	0	57
retinoid X nuclear receptor alpha	46	0	0	46
estrogen-related nuclear receptor alpha	66	0	0	66
farnesoid X nuclear receptor	35	0	0	35
pregnane X nuclear receptor	55	0	0	55
estrogen nuclear receptor alpha	87	0	0	87
G	29	0	0	29
vitamin D (1,25- dihydroxyvitamin D3) receptor	41	0	0	41
arylsulfatase A	17	0	0	17
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	39	0	0	39
activating transcription factor 6	25	0	0	25
nuclear receptor subfamily 1, group I, member 2	13	0	0	13
chromobox protein homolog 1	38	0	0	38
nuclear factor erythroid 2-related factor 2 isoform 1	57	0	0	57
survival motor neuron protein isoform d	21	0	0	21
histone acetyltransferase KAT2A isoform 1	19	0	0	19
lamin isoform A-delta10	46	0	0	46
Voltage-dependent calcium channel gamma-2 subunit	32	0	0	32
Interferon beta	39	0	0	39
HLA class I histocompatibility antigen, B alpha chain	29	0	0	29
Glucocorticoid receptor	0	25	2	33
Glycine receptor subunit alpha-1	0	24	0	24
Corticosteroid-binding globulin	0	12	0	12
Adenosine receptor A3	0	16	0	16
Replicase polyprotein 1ab	0	7	2	9
Androgen receptor	0	31	1	32
Alpha-1B adrenergic receptor	0	27	1	28
Glutamate receptor 2	33	0	0	35
Glycine receptor subunit beta	0	24	0	24
Glycine receptor subunit alpha-2	0	24	0	24
Glycine receptor subunit alpha-3	0	24	0	24
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	29	1	30
Sodium-dependent dopamine transporter	0	24	2	26
TAR DNA-binding protein 43	14	0	0	14
Inositol hexakisphosphate kinase 1	29	0	0	29
cytochrome P450 2C9, partial	29	0	0	29
ATP-dependent phosphofructokinase	21	0	0	21
hypoxia-inducible factor 1 alpha subunit	22	0	0	22
RAR-related orphan receptor gamma	55	0	0	55
peroxisome proliferator-activated receptor delta	36	0	0	36
v-jun sarcoma virus 17 oncogene homolog (avian)	31	0	0	31
Histone H2A.x	25	0	0	25
thyroid hormone receptor beta isoform a	21	0	0	21
heat shock protein beta-1	19	0	0	19
Estrogen receptor	0	20	6	28
Cytochrome P450 2C9	0	22	1	25
Estrogen receptor beta	0	8	5	14
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	22	0	0	22
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	14	3	18
Delta-type opioid receptor	0	8	2	11
Kappa-type opioid receptor	0	10	3	14
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	15	0	0	15
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	21	0	0	21
Mineralocorticoid receptor	0	4	3	7
Mineralocorticoid receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	4	0	6
Guanine nucleotide-binding protein G	6	0	0	6
interleukin 8	15	0	0	15
thyroid stimulating hormone receptor	24	0	0	24
estrogen receptor 2 (ER beta)	35	0	0	35
Bloom syndrome protein isoform 1	16	0	0	16
transcriptional regulator ERG isoform 3	10	0	0	10
thyroid hormone receptor beta isoform 2	49	0	0	49
ras-related protein Rab-9A	12	0	0	12
ATP-binding cassette sub-family C member 3	0	47	0	47
Multidrug resistance-associated protein 4	0	48	0	51
Polyphenol oxidase 2	0	3	0	5
Bile salt export pump	0	67	0	67
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	3
Cellular tumor antigen p53	39	0	0	39
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	9	3	13
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	43	0	44
Shiga toxin subunit A	0	2	0	2
Histamine H3 receptor	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	27	0	0	27
thioredoxin reductase	32	0	0	32
cytochrome P450 family 3 subfamily A polypeptide 4	41	0	0	41
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	21	0	0	21
peripheral myelin protein 22 isoform 1	15	0	0	15
potassium voltage-gated channel subfamily H member 2 isoform d	18	0	0	18
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	14	0	0	14
cytochrome P450 3A4 isoform 1	27	0	0	27
Gamma-aminobutyric acid receptor subunit pi	27	3	2	32
Sterol O-acyltransferase 1	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Aromatase	0	15	0	22
Gamma-aminobutyric acid receptor subunit beta-1	27	3	2	32
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	5	0	5
Gamma-aminobutyric acid receptor subunit delta	27	3	2	32
Gamma-aminobutyric acid receptor subunit gamma-2	27	3	2	32
Gamma-aminobutyric acid receptor subunit alpha-5	27	3	2	32
Gamma-aminobutyric acid receptor subunit alpha-3	27	3	2	32
Aromatase	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	27	3	2	32
Gamma-aminobutyric acid receptor subunit alpha-2	27	3	2	32
Thromboxane-A synthase	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	27	3	2	32
Gamma-aminobutyric acid receptor subunit gamma-3	27	3	2	32
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	27	3	2	32
Delta-type opioid receptor	0	3	1	5
Gamma-aminobutyric acid receptor subunit alpha-1	27	4	2	33
Gamma-aminobutyric acid receptor subunit beta-3	27	3	2	32
Gamma-aminobutyric acid receptor subunit beta-2	27	3	2	32
GABA theta subunit	27	3	2	32
Gamma-aminobutyric acid receptor subunit epsilon	27	3	2	32
nuclear receptor subfamily 1, group I, member 3	43	0	0	43
peroxisome proliferator activated receptor gamma	41	0	0	41
Dihydrofolate reductase	0	5	0	6
Dihydrofolate reductase	0	4	0	6
Dihydrofolate reductase	0	3	0	5
5-hydroxytryptamine receptor 2C	0	12	2	16
Dihydrofolate reductase	0	3	3	6
Folylpolyglutamate synthase, mitochondrial	0	2	0	6
Solute carrier organic anion transporter family member 1A3	0	2	0	6
Folylpolyglutamate synthase, mitochondrial	0	1	0	6
Chain A, HADH2 protein	20	0	0	20
Chain B, HADH2 protein	20	0	0	20
USP1 protein, partial	28	0	0	28
NFKB1 protein, partial	10	0	0	10
GLS protein	18	0	0	18
cytochrome P450 2D6	25	0	0	25
cytochrome P450 2D6 isoform 1	15	0	0	15
D(1A) dopamine receptor	14	0	0	14
atrial natriuretic peptide receptor 2 precursor	9	0	0	9
serine/threonine-protein kinase mTOR isoform 1	15	0	0	15
muscarinic acetylcholine receptor M1	21	0	0	21
Solute carrier family 22 member 1	0	7	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15B	15	0	0	15
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
5-hydroxytryptamine receptor 4	0	20	0	20
Albumin	0	0	8	8
High affinity nerve growth factor receptor	0	1	2	3
Aldo-keto reductase family 1 member B1	0	24	0	24
Muscarinic acetylcholine receptor M2	0	22	1	23
Muscarinic acetylcholine receptor M4	0	22	1	23
Muscarinic acetylcholine receptor M1	0	11	1	12
Muscarinic acetylcholine receptor M3	0	10	1	11
Muscarinic acetylcholine receptor M4	0	10	1	11
Muscarinic acetylcholine receptor M5	0	11	1	12
Muscarinic acetylcholine receptor M5	0	23	0	23
Alpha-2A adrenergic receptor	0	25	1	26
Muscarinic acetylcholine receptor M2	0	10	1	11
Muscarinic acetylcholine receptor M1	0	24	3	28
Angiotensin-converting enzyme	0	15	0	15
D(2) dopamine receptor	0	19	1	26
5-hydroxytryptamine receptor 2A	0	12	3	15
Alpha-2B adrenergic receptor	0	24	1	25
Alpha-2C adrenergic receptor	0	19	1	20
5-hydroxytryptamine receptor 1A	0	18	2	20
Muscarinic acetylcholine receptor M3	0	23	1	24
D(1A) dopamine receptor	0	17	0	20
D(1B) dopamine receptor	0	6	0	9
UDP-glucuronosyltransferase 1A4	0	3	0	11
Sodium-dependent noradrenaline transporter	0	29	2	31
Histamine H2 receptor	0	14	0	14
Alpha-1D adrenergic receptor	0	19	1	20
5-hydroxytryptamine receptor 2A	0	26	1	29
5-hydroxytryptamine receptor 2C	0	22	1	23
5-hydroxytryptamine receptor 1B	0	12	1	13
5-hydroxytryptamine receptor 1D	0	5	1	6
5-hydroxytryptamine receptor 1F	0	5	1	6
5-hydroxytryptamine receptor 2B	0	11	3	14
5-hydroxytryptamine receptor 6	0	2	1	3
Histamine H1 receptor	0	6	0	6
Sodium-dependent serotonin transporter	0	34	2	36
5-hydroxytryptamine receptor 7	0	6	1	7
5-hydroxytryptamine receptor 5A	0	2	1	3
5-hydroxytryptamine receptor 5B	0	2	1	3
Histamine H1 receptor	0	15	3	20
D(3) dopamine receptor	0	23	1	29
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 4 subunit alpha	0	6	0	8
UDP-glucuronosyltransferase 1A3	0	0	0	3
5-hydroxytryptamine receptor 3A	0	3	1	4
5-hydroxytryptamine receptor 2B	0	27	1	28
Histamine H2 receptor	19	2	1	24
D(1A) dopamine receptor	11	1	0	12
5-hydroxytryptamine receptor 6	0	21	0	22
5-hydroxytryptamine receptor 7	0	5	0	5
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Potassium voltage-gated channel subfamily H member 2	0	21	0	21
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Sodium channel protein type 5 subunit alpha	0	5	0	5
Sodium channel protein type 9 subunit alpha	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	4	2	6
5-hydroxytryptamine receptor 4	0	2	1	3
Nuclear receptor subfamily 3 group C member 3	0	13	0	13
Sodium channel protein type 2 subunit alpha	0	5	0	5
Ataxin-2	27	0	0	27
Sigma non-opioid intracellular receptor 1	0	15	1	16
5-hydroxytryptamine receptor 3B	0	3	1	4
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	4	0	4
Sodium channel protein type 8 subunit alpha	0	4	0	4
Histamine H3 receptor	0	4	0	4
Sodium channel protein type 10 subunit alpha	0	4	0	4
Chain A, Beta-lactamase	18	0	0	18
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	10	0	0	10
Beta-lactamase	0	0	0	1
DNA polymerase eta isoform 1	7	0	0	7
urokinase-type plasminogen activator precursor	11	0	0	11
plasminogen precursor	11	0	0	11
urokinase plasminogen activator surface receptor precursor	11	0	0	11
DNA polymerase kappa isoform 1	12	0	0	12
Bile salt export pump	0	11	0	11
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	3	2	6
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	13	0	14
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
phosphopantetheinyl transferase	17	0	0	17
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	24	0	0	24
peripheral myelin protein 22	36	0	0	36
Cytochrome P450 1A2	0	3	1	6
Cytochrome P450 3A4	0	15	0	20
Cytochrome P450 2D6	0	14	1	16
Cytochrome P450 2C19	0	7	0	10
Nuclear receptor ROR-gamma	17	0	0	17
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	7
Amine oxidase [flavin-containing] A	0	3	0	3
Spike glycoprotein	21	1	2	24
Smad3	15	0	0	15
nonstructural protein 1	7	0	0	7
Caspase-7	6	0	0	6
caspase-3	6	0	0	6
importin subunit beta-1 isoform 1	6	0	0	6
mitogen-activated protein kinase 1	14	0	0	14
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
snurportin-1	6	0	0	6
GTP-binding nuclear protein Ran isoform 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	18	0	0	18
muscleblind-like protein 1 isoform 1	9	0	0	9
neuropeptide S receptor isoform A	5	0	0	5
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	3	0	3
Alpha-synuclein	7	4	0	11
Chain A, retinol dehydratase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	8	0	8
G-protein coupled bile acid receptor 1	0	0	5	5
glucocerebrosidase	11	0	0	11
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	3	1	4
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	5	0	5
Type-1 angiotensin II receptor	0	4	2	7
Type-2 angiotensin II receptor	0	3	0	3
Type-2 angiotensin II receptor	0	3	0	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	4	0	0	4
cytochrome P450 2C19 precursor	10	0	0	10
flap endonuclease 1	11	0	0	11
lethal factor (plasmid)	15	0	0	15
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	16	0	0	16
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	28	0	0	28
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	7	0	7
Carbonic anhydrase 1	0	10	0	13
Carbonic anhydrase 2	0	13	1	18
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	9	1	0	10
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	9	1	0	10
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	7	0	7
Adenosine receptor A1	0	8	0	11
Adenosine receptor A2a	0	3	0	7
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	5	0	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	6	2	8
Luciferase	16	0	0	16
lysosomal alpha-glucosidase preproprotein	6	0	0	6
Neuronal acetylcholine receptor subunit alpha-4	3	0	0	3
Neuronal acetylcholine receptor subunit beta-2	3	0	0	3
Thromboxane A2 receptor	0	1	1	3
Endothelin-1 receptor	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	3
Multidrug and toxin extrusion protein 1	0	7	0	7
Leukotriene B4 receptor 2	0	0	1	1
glp-1 receptor, partial	16	0	0	16
ATAD5 protein, partial	24	0	0	24
Fumarate hydratase	15	0	0	15
PPM1D protein	11	0	0	11
Thrombopoietin	6	0	0	6
polyprotein	15	0	0	15
67.9K protein	21	0	0	21
Parkin	4	0	0	4
aryl hydrocarbon receptor	21	0	0	21
thyroid stimulating hormone receptor	23	0	0	23
hemoglobin subunit beta	4	0	0	4
cellular tumor antigen p53 isoform a	13	0	0	13
huntingtin isoform 2	4	0	0	4
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A1	0	10	1	13
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	17	0	0	17
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
BRCA1	1	0	0	1
15-lipoxygenase, partial	9	0	0	9
Microphthalmia-associated transcription factor	0	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	1	0	4
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Glycoprotein hormones alpha chain	2	0	0	2
Transcriptional activator protein LasR	0	1	0	1
Chain A, Ferritin light chain	16	0	0	16
P53	1	0	0	1
M-phase phosphoprotein 8	13	0	0	13
Protein-arginine deiminase type-4	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	9	0	0	9
Rap guanine nucleotide exchange factor 3	6	0	0	6
D(4) dopamine receptor	0	13	1	19
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	12	0	0	12
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	11	0	0	11
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	4	0	6
Thymidine phosphorylase	0	0	0	3
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	3
Thymidylate kinase	0	2	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	12	3	17
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	3	3
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	4	0	4
Vitamin D3 receptor A	0	0	2	2
Vpr	3	0	0	3
Major prion protein	0	0	5	5
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	3	0	6
Cytochrome P450 2B6	0	2	1	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
caspase 7, apoptosis-related cysteine protease	9	0	0	9
caspase-3	9	0	0	9
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
thyrotropin-releasing hormone receptor	3	0	0	3
Caspase-2	0	0	1	1
streptokinase A precursor	0	0	3	3
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Carbonic anhydrase 4	0	4	0	7
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase 15	0	2	0	4
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	2	0	2
Snq2p	0	0	0	3
Adenylate cyclase type 1	0	4	0	4
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	3	3	6
histone deacetylase 9 isoform 3	4	0	0	4
Proteasome subunit alpha type-7	0	0	0	1
Transmembrane protease serine 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Potassium channel subfamily K member 2	0	3	2	5
Albumin	0	2	4	6
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	0	3
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Major prion protein	0	1	1	2
Tyrosine-protein kinase Fyn	0	5	0	5
Procathepsin L	0	1	2	3
ATP-dependent translocase ABCB1	0	17	3	29
5-hydroxytryptamine receptor 1A	0	9	1	10
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	2	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	9	0	9
Sphingomyelin phosphodiesterase	0	2	0	2
D	0	9	0	9
D(3) dopamine receptor	0	11	0	11
Alpha-2B adrenergic receptor	0	11	1	12
D(2) dopamine receptor	0	5	0	5
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	8	0	8
Adenylate cyclase type 3	0	4	0	4
Alpha-2C adrenergic receptor	0	11	1	12
Alpha-2A adrenergic receptor	0	11	1	12
Alpha-1D adrenergic receptor	0	13	1	14
Sodium-dependent dopamine transporter	0	8	1	9
D(1B) dopamine receptor	0	8	0	8
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	6	0	6
D(4) dopamine receptor	0	9	0	9
Histamine H1 receptor	0	3	1	4
Melanocortin receptor 4	0	4	0	4
Melanocortin receptor 5	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
5-hydroxytryptamine receptor 7	0	6	0	6
Glutamate receptor ionotropic, NMDA 1	0	3	1	7
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Melanocortin receptor 3	0	4	0	4
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	11	1	13
Calmodulin	0	1	3	4
Aldehyde oxidase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2B	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	7
Adenylate cyclase type 6	0	4	0	4
Adenylate cyclase type 5	0	4	0	4
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	5	0	5
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
D	0	4	0	4
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
5-hydroxytryptamine receptor 3E	0	2	0	2
Beta-1 adrenergic receptor	0	1	2	4
cytochrome P450 2C9 precursor	7	0	0	7
DNA polymerase beta	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	2	0	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Beta-2 adrenergic receptor	0	6	1	7
Beta-1 adrenergic receptor	0	5	2	8
Endothelin receptor type B	1	1	0	2
5-hydroxytryptamine receptor 3A	0	2	0	2
Endothelin receptor type B	0	1	0	1
Beta-3 adrenergic receptor	0	3	1	4
Sodium-dependent serotonin transporter	0	5	1	6
5-hydroxytryptamine receptor 2C	0	3	0	3
Alpha-1A adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 2A	0	2	0	2
Alpha-1B adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 3A	0	2	0	2
5-hydroxytryptamine receptor 5A	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Cholecystokinin receptor type A	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 3D	0	2	0	2
5-hydroxytryptamine receptor 3C	0	2	0	2
Histamine H4 receptor	0	1	1	2
Transporter	0	5	0	5
endonuclease IV	7	0	0	7
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	1	0	4
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	1	0	2
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
dopamine D1 receptor	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Progesterone receptor	0	7	3	11
Adenosine receptor A2b	0	2	0	3
ORF73	0	0	1	1
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	5	0	7
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
Solute carrier family 22 member 2	0	5	0	7
Prothrombin	0	2	1	4
Coagulation factor X	0	1	0	1
Plasminogen	0	1	0	1
Coagulation factor XII	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Trypsin-3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	3	0	3
Matrix metalloproteinase-9	0	2	0	2
Isocitrate lyase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	2	0	5
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Steryl-sulfatase	0	3	0	4
Multidrug resistance-associated protein 1	0	0	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	3
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B3	0	4	0	7
Solute carrier family 22 member 11	0	0	0	3
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	5
Vascular endothelial growth factor receptor 2	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	0	1	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Glutamate receptor 1	1	0	0	3
Glutamate receptor 3	1	0	0	3
Glutamate receptor 4	1	0	0	3
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	7	0	0	7
serine/threonine-protein kinase PLK1	6	0	0	6
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
high affinity choline transporter 1 isoform a	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	1	2	3
Beta-1 adrenergic receptor	0	9	2	11
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Acetylcholinesterase	0	4	0	4
Vasopressin V1a receptor	0	2	0	2
Estrogen-related receptor gamma	0	1	1	2
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
UDP-glucose 4-epimerase	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
Cysteinyl leukotriene receptor 1	0	2	0	2
STAT3, partial	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	7	0	0	7
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	3	0	3
Sodium/potassium-transporting ATPase subunit gamma	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	3	0	3
Solute carrier organic anion transporter family member 4C1	0	2	0	3
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
Progesterone receptor	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Sex hormone-binding globulin	0	1	0	1
Androgen receptor	0	1	1	2
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Muscarinic acetylcholine receptor	0	3	0	3
Neuropeptide FF receptor 2	0	0	0	1
ALK tyrosine kinase receptor	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Prostaglandin D2 receptor	0	1	0	1
Solute carrier family 22 member 6	0	1	0	4
Solute carrier family 22 member 7	0	0	0	2
Solute carrier family 22 member 8	0	2	0	4
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	3	1	0	4
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
ubiquitin-conjugating enzyme E2 N	0	2	0	2
protein AF-9 isoform a	0	0	0	1
Beta-3 adrenergic receptor	0	5	2	7
C-8 sterol isomerase	0	4	0	4
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	5	1	6
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	1	1	2
UDP-glucuronosyltransferase 1A10	0	0	0	1
GALC protein	4	0	0	4
hexokinase-4 isoform 1	4	0	0	4
glucokinase regulatory protein	4	0	0	4
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	5	3	8
Mu-type opioid receptor	0	2	2	4
Cytochrome P450 1B1	0	2	0	2
Ghrelin O-acyltransferase	0	1	0	1
Cytochrome P450 2B1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	4	0	6
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
ClpP	4	0	0	4
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Integrase	0	1	0	1
interferon gamma precursor	0	0	0	2
Sodium/nucleoside cotransporter 2	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	2	0	0	2
Thymidylate synthase	0	4	0	4
Aldo-keto reductase family 1 member B1	0	2	0	2
Multidrug resistance associated protein	0	1	0	3
Purine nucleoside phosphorylase	0	2	0	2
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Guanine deaminase	0	1	0	2
Cocaine esterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Delta-type opioid receptor	0	4	2	6
Kappa-type opioid receptor	0	3	2	5
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	3	0	3
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Protease	0	5	0	5
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
WRN	2	0	0	2
Mcl-1	0	2	0	2
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
luciferase	1	0	0	1
pyruvate kinase	2	0	0	2
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	2	0	0	2
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
Vif	0	1	0	1
Tat	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
Pyruvate kinase PKM	0	1	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	2	0	0	2
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	4	0	5
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Amino acid transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Stromelysin-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	3
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	3
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-2	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Carbonic anhydrase 9	0	4	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Geranylgeranyl pyrophosphate synthase	0	3	0	4
Farnesyl pyrophosphate synthase	0	4	0	4
DNA polymerase III, partial	2	0	0	2
NPYLR7B	0	0	3	3
eyes absent homolog 2 isoform a	1	0	0	1
tumor susceptibility gene 101 protein	3	0	0	3
Single-stranded DNA cytosine deaminase	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Envelope glycoprotein	0	0	2	2
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Solute carrier family 22 member 1	0	3	0	5
Solute carrier family 22 member 2	0	3	0	3
beta-2 adrenergic receptor	1	0	0	1
Beta-2 adrenergic receptor	0	5	3	9
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	1	3	4
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	2	0	2
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
Microtubule-associated protein tau	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	0	1
Fatty acid synthase	0	4	0	4
WD repeat-containing protein 5	0	2	0	2
Histone-lysine N-methyltransferase 2A	0	2	0	2
Cytosolic endo-beta-N-acetylglucosaminidase	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Carbonic anhydrase 12	0	2	0	5
Tyrosine-protein kinase Lck	0	2	0	2
Carbonic anhydrase 3	0	1	0	4
Carbonic anhydrase 6	0	1	0	4
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	3	0	4
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase-like protein, putative	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 13	0	1	0	4
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	1	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
D	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	1	2
Carboxylic ester hydrolase	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Reduced folate transporter	0	2	0	2
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Proton-coupled folate transporter	0	1	0	1
Serine racemase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	1	1	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Kappa-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Estrogen receptor	0	0	2	3
Estrogen receptor beta	0	0	2	3
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
pyruvate kinase PKM isoform a	1	0	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	2	0	2
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Glutathione S-transferase omega-1	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase 13	0	0	0	1
Phospholipase A-2-activating protein	0	2	0	2
Gamma-aminobutyric acid	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Free fatty acid receptor 1	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	2	6	9
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Lanosterol 14-alpha demethylase	0	2	0	2
N	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
Riboflavin-binding protein	0	1	1	2
Histidine-rich protein PFHRP-II	0	2	0	2
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Cholinesterase	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Transcriptional activator protein LuxR	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Tyrosinase	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Cystine/glutamate transporter	0	1	0	1
Chain A, CES1 protein	0	1	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	2	0	2
Protein kinase C beta type	0	1	0	1
Protein kinase C delta type	0	2	0	2
Protein kinase C epsilon type	0	2	0	2
Protein kinase C zeta type	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	0	2
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	2	0	2
Emopamil-binding protein-like	0	2	0	2
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	2	0	2
Cereblon isoform 4	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Renin	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Endochitinase B1	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Genome polyprotein	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Lysozyme C-1	0	1	0	1
Beta-glucuronidase	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Chain A, Arginase 1	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Butyrophilin subfamily 3 member A1	0	0	1	2
72 kDa type IV collagenase	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Studies (823)

Protein Targets (1,418)

Klinefelter Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Actions

Research

Studies (823)

Drugs Studied (229)

Protein Targets (1,418)