Page last updated: 2024-09-27

Post-operative Vasoplegic Syndrome

Condition of low SYSTEMIC VASCULAR RESISTANCE that develops secondary to other conditions such as ANAPHYLAXIS; SEPSIS; SURGICAL SHOCK; and SEPTIC SHOCK. Vasoplegia that develops during or post surgery (e.g., CARDIOPULMONARY BYPASS) is called postoperative vasoplegic syndrome or vasoplegic syndrome.

Synonyms(4)

Synonym
Vasoplegic Syndrome
Postoperative Vasoplegic Syndrome
Vasoplegia
Post-operative Vasoplegic Syndrome

Research Excerpts

Overview

ExcerptReference
"Vasoplegic syndrome is a common complication of cardiopulmonary bypass, appearing with an incidence ranging between 5 and 25%."( Lenglet, S; Mach, F; Montecucco, F, 2011)
"Septic vasoplegia is due to reduced endogenous production of vasopressin, as well as to the overproduction of vasodilating molecules (nitric oxide, prostacyclin, peroxynitrite and kynurenine) and the opening of ATP-sensitive potassium channels."( Jeanneret, S; Liaudet, L; Sanchez, B, 2011)
"Vasoplegic syndrome is a state of endothelial dysregulation that produces profound vasodilatation that is refractory to vasopressors."( Arndt, KL; Lutjen, DL, 2012)
"Vasoplegia is a key factor for the death of patients with septic shock in intensive care unit owing to persistent and irreversible hypotension."( Sharawy, N, 2014)
"Vasoplegia is considered as a key factor responsible for the death of patients with septic shock, due to persistent and irreversible hypotension."( Chikhladze, KhE; Gamcrlidze, MM; Goliadze, LSh; Intskirveli, NA; Ratiani, LR; Vardosanidze, KD, 2015)
"Systemic vasoplegia is common in patients undergoing liver transplantation."( Boettcher, BT; Cronin, DC; Hong, JC; Kim, J; Lauer, KK; Selim, M; Woehlck, HJ; Zimmerman, MA, 2016)
"Vasoplegic syndrome is a common complication after cardiac surgery and impacts negatively on patient outcomes."( Barbosa Gomes Galas, FR; Camara, L; Costa Auler, JO; Dallan, LO; de Almeida, JP; Fernandes, FL; Filho, RK; Franco, RA; Fukushima, JT; Gaiane, MA; Gaiotto, FA; Gerent, AM; Grande, SM; Hajjar, LA; Jatene, FB; Landoni, G; Lisboa, LA; Melo, RR; Nakamura, RE; Osawa, EA; Park, CL; Piccioni, MA; Pomerantzeff, PM; Rhodes, A; Rocha Ferreira, GS; Santos, VG; Souza, DH; Strabelli, TM; Sundin, MR; Vincent, JL; Zambolim, C; Zeferino, S, 2017)
"Vasoplegic syndrome is an unusual cause of refractory hypotension under general anesthesia."( Anandaswamy, TC; Krishnamachar, H; Rajappa, GC, 2017)
"Vasoplegic syndrome is a form of vasodilatory shock that occurs frequently in patients who undergo cardiac surgery requiring cardiopulmonary bypass (CBP)."( Booth, AT; Mehaffey, JH; Melmer, PD; Tribble, B; Tribble, C, 2017)
"Vasoplegic syndrome is a state of persistent hypotension with elevated cardiac output, low filling pressures, and low systemic vascular resistance (SVR)."( Duce, L; Ghadimi, K; McCartney, SL, 2018)
"Vasoplegia is a ubiquitous phenomenon in all advanced shock states, including septic, cardiogenic, hemorrhagic, and anaphylactic shock."( Auchet, T; Fritz, C; Jacquot, A; Kimmoun, A; Levy, B; Tahon, E, 2018)
"Vasoplegia is the syndrome of pathological low systemic vascular resistance, the dominant clinical feature of which is reduced blood pressure in the presence of a normal or raised cardiac output."( Creagh-Brown, BC; Forni, LG; Hunt, J; Lambden, S; Summers, C, 2018)
"Vasoplegic syndrome is a common occurrence following cardiothoracic surgery and is characterized as a high-output shock state with poor systemic vascular resistance."( Barker, N; Busse, LW; Petersen, C, 2020)
"Vasoplegia is a frequent complication of left ventricular assist device (LVAD) implantation."( Colombo, PC; Jennings, DL; Kurlansky, P; Miltiades, AN; Naka, Y; Ning, Y; Saha, A; Sanchez, J; Spellman, JL; Takayama, H; Takeda, K; Yuzefpolskaya, M, 2021)
"Vasoplegia is a common complication in cardiac surgery with cardiopulmonary bypass and is associated with significant morbidity and mortality."( Chatterjee, S; Evans, AS; Friedman, B; Greenfeld, CR; Khanna, AK; Klijian, A; Kroll, S; Ortoleva, J; Panwar, R; Reddy, VS, 2021)
"Vasoplegia is a common complication after cardiac surgery and is related to the use of cardiopulmonary bypass (CPB)."( Danser, AHJ; Palmen, M; Papazisi, O, 2022)
"BACKGROUND Cardiac vasoplegic syndrome is a form of vasodilatory shock characterized by profound vasodilation and low systemic vascular resistance, which results in significant hypotension despite high cardiac output and appropriate fluid resuscitation."( Finamore, M; Peyko, V, 2021)
"Vasoplegic syndrome is a rising problem affecting morbidity and mortality in patients undergoing cardiac surgery."( Nash, CM, 2021)
"Vasoplegia is a common complication after cardiac surgery and is associated with poor prognosis."( Arbous, MS; Beeres, SLMA; Berendsen, RR; Bruggemans, EF; Hugo, JDV; Ince, C; Klautz, RJM; Lindeman, JHN; Mertens, BJA; Palmen, M; Papazisi, O; van den Hout, WB, 2022)
"Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation."( Jatoi, HN; Ochani, RK; Ratnani, I; Shaikh, A, 2023)

Context

ExcerptReference
"Vasoplegia has been described as a complication after cardiac surgery, particularly in patients with a poor left ventricular ejection fraction."( Beeres, SL; Berendsen, RR; Couperus, LE; de Jonge, E; Klautz, RJ; Mertens, B; Palmen, M; Schalij, MJ; Tops, LF; van Vessem, ME; Verwey, HF, 2017)

Treatment

ExcerptReference
"The term vasoplegia describes hypotension refractory to vasopressor therapy, a common finding related to cardiac surgery requiring cardiopulmonary bypass."( Arevalo, VN; Bullerwell, ML, 2018)

Research

Studies (161)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (0.62)23.3326
1990's0 (0.00)12.5806
2000's1 (0.62)18.1394
2010's99 (61.49)28.8240
2020's60 (37.27)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrogen sulfide0low20
lactic acid0medium42
nitrous oxide0low10
aspirin0low10
citalopram0low10
cyproheptadine0low10
gliclazide0low10
lorazepam0low10
metformin0low10
nimodipine0low10
thyroxine0low10
phenylephrine0medium31
methylene blue0medium700
deoxycytidine0low10
dobutamine0low10
diltiazem0low10
gemcitabine0low10
valsartan0low20
terlipressin0low10
droxidopa0low10
cobalt0low20
p-methoxy-n-methylphenethylamine0low10
peroxynitrous acid0low10
angiotensin ii0medium181
rocuronium0low10
lypressin0low10
arginine vasopressin0low20
indigo carmine0low10
dinoprostone0low10
vitamin k semiquinone radical0low10
6-ketoprostaglandin f1 alpha0low10
losartan potassium0low10
pituitrin0medium142
ziconotide0low10
cardiovascular agents0low30
interleukin-80low10
hydroxocobalamin0low360
natriuretic peptide, brain0low10
ascorbic acid0medium52
adrenomedullin0low10
vitamin b 120low20
cyclic gmp0low30

Protein Targets (526)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Solute carrier organic anion transporter family member 2A10002
glucocerebrosidase3003
DNA polymerase kappa isoform 13003
histone acetyltransferase KAT2A isoform 15005
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0426
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0505
Type-1 angiotensin II receptor0438
Type-2 angiotensin II receptor0303
Type-2 angiotensin II receptor0303
vitamin D3 receptor isoform VDRA4004
peripheral myelin protein 226006
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010012
Bile salt export pump013013
Translocator protein0011
Vasopressin V2 receptor0214
Oxytocin receptor0112
Vasopressin V1a receptor0022
Vasopressin V1a receptor0112
Vasopressin V1b receptor0112
Vasopressin V2 receptor0011
Vasopressin V1b receptor0113
Translocator protein0102
Oxytocin receptor0101
Vasopressin V2 receptor 0112
Canalicular multispecific organic anion transporter 10909
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase3003
RAR-related orphan receptor gamma5005
GLI family zinc finger 35005
AR protein9009
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 4110011
glucocorticoid receptor [Homo sapiens]8008
retinoic acid nuclear receptor alpha variant 18008
estrogen-related nuclear receptor alpha100010
estrogen nuclear receptor alpha140014
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
IDH13003
euchromatic histone-lysine N-methyltransferase 2100010
chromobox protein homolog 17007
nuclear factor erythroid 2-related factor 2 isoform 22002
thyroid hormone receptor beta isoform 27007
nuclear factor erythroid 2-related factor 2 isoform 15005
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin9009
lethal factor (plasmid)3003
lamin isoform A-delta108008
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0102
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0516
Spike glycoprotein8019
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
thioredoxin reductase8008
GLS protein6006
aldehyde dehydrogenase 1 family, member A14004
thyroid stimulating hormone receptor5005
hypothetical protein, conserved2002
EWS/FLI fusion protein8008
cytochrome P450 2D67007
peroxisome proliferator-activated receptor delta3003
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 13003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase iota isoform a (long)4004
muscarinic acetylcholine receptor M12002
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Epidermal growth factor receptor0202
Carbonic anhydrase 10404
Carbonic anhydrase 20404
Fatty acid-binding protein, liver0202
Integrin beta-31102
Myeloperoxidase0101
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10101
Integrin alpha-IIb1102
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0202
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-11102
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10112
NPC intracellular cholesterol transporter 1 precursor1001
D(1A) dopamine receptor5005
survival motor neuron protein isoform d2002
Solute carrier family 22 member 1 0405
Sodium-dependent noradrenaline transporter0202
5-hydroxytryptamine receptor 40404
Aldo-keto reductase family 1 member B10606
Tryptophan 5-hydroxylase 10101
Angiotensin-converting enzyme0404
Aldo-keto reductase family 1 member B10101
5-hydroxytryptamine receptor 1A0303
Acetylcholinesterase0101
Aromatase0101
Sodium-dependent noradrenaline transporter 0617
Sodium-dependent dopamine transporter0101
Alpha-1D adrenergic receptor0606
5-hydroxytryptamine receptor 2C0404
Sodium-dependent serotonin transporter0516
Sodium-dependent serotonin transporter0101
Histamine H1 receptor0415
5-hydroxytryptamine receptor 2B0404
5-hydroxytryptamine receptor 70202
Sodium-dependent dopamine transporter 0303
Potassium voltage-gated channel subfamily H member 20505
Sigma intracellular receptor 20101
Sodium-dependent serotonin transporter0202
Sodium-dependent dopamine transporter0101
Nuclear receptor subfamily 3 group C member 3 0404
Ataxin-25005
Transporter0303
ATP-dependent phosphofructokinase2002
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
phosphopantetheinyl transferase4004
ATAD5 protein, partial3003
Fumarate hydratase4004
PPM1D protein2002
TDP1 protein8008
nuclear receptor subfamily 1, group I, member 34004
regulator of G-protein signaling 44004
farnesoid X nuclear receptor4004
polyprotein4004
v-jun sarcoma virus 17 oncogene homolog (avian)4004
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d3003
huntingtin isoform 24004
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
chaperonin GroEL1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent calcium channel gamma-2 subunit2002
Interferon beta4004
Cellular tumor antigen p537007
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0314
Muscarinic acetylcholine receptor M20101
Glycogen phosphorylase, brain form0101
Glycogen phosphorylase, muscle form0101
Muscarinic acetylcholine receptor M10202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 2A0202
Alpha-2C adrenergic receptor0314
D0101
D(3) dopamine receptor0101
Glutamate receptor 22002
Muscarinic acetylcholine receptor M30202
Endothelin receptor type B0101
D(1A) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Endothelin receptor type B0101
Histamine H2 receptor0202
D(1B) dopamine receptor0101
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 1B0202
D(4) dopamine receptor0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 2C 0101
5-hydroxytryptamine receptor 70101
D(3) dopamine receptor0404
UDP-glucuronosyltransferase 1A30001
Histamine H2 receptor2002
5-hydroxytryptamine receptor 60202
D(2) dopamine receptor0101
D(2) dopamine receptor0202
Histone-lysine N-methyltransferase SETD70202
Thymidine kinase 2 0101
Deoxycytidine kinase0002
Probable deoxycytidylate deaminase0001
Cytidine deaminase0002
AAA family ATPase 0002
Reverse transcriptase/RNaseH 0011
estrogen receptor 2 (ER beta)4004
retinoid X nuclear receptor alpha3003
pregnane X nuclear receptor5005
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent L-type calcium channel subunit alpha-1F0202
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40214
Cytochrome P450 2C9 0202
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Voltage-dependent L-type calcium channel subunit alpha-1D0202
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0202
Cytochrome P450 2J20202
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Potassium voltage-gated channel subfamily A member 10101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
GABA theta subunit1001
Sodium channel protein type 2 subunit alpha0101
Gamma-aminobutyric acid receptor subunit epsilon1001
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
Chain A, Cruzipain2002
SMAD family member 22002
SMAD family member 32002
thyroid stimulating hormone receptor4004
activating transcription factor 63003
prostaglandin E2 receptor EP2 subtype1001
mitogen-activated protein kinase 12002
Solute carrier family 22 member 20102
Solute carrier organic anion transporter family member 1A50002
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier family 22 member 60001
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 80001
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
dopamine D1 receptor2002
glp-1 receptor, partial4004
GALC protein1001
peroxisome proliferator activated receptor gamma3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
Histone H2A.x3003
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
Carbonic anhydrase 120101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Carbonic anhydrase 30101
Beta-2 adrenergic receptor0213
Beta-1 adrenergic receptor0213
Polyunsaturated fatty acid lipoxygenase ALOX150101
POU domain, class 2, transcription factor 10002
Carbonic anhydrase 40202
Carbonic anhydrase 60202
Carbonic anhydrase 5A, mitochondrial0202
Carbonic anhydrase 70202
Carbonic anhydrase 90202
Carbonic anhydrase 130101
Carbonic anhydrase 150101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0202
Nuclear receptor subfamily 1 group I member 20033
Nuclear receptor subfamily 1 group I member 20011
Chain A, DEOXYNUCLEOSIDE KINASE0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Equilibrative nucleoside transporter 10101
Angiotensin-converting enzyme 2 0011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
bromodomain adjacent to zinc finger domain 2B3003
Bile salt export pump0101
Aldo-keto reductase family 1 member C30101
Aldo-keto reductase family 1 member C2 0101
Inositol monophosphatase 12002
Aldo-keto reductase family 1 member C10101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0101
Transient receptor potential cation channel subfamily A member 10011
Carbonic anhydrase 130101
Luciferase3003
histone deacetylase 9 isoform 32002
ATPase family AAA domain-containing protein 52002
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0101
Glutamate receptor ionotropic, NMDA 3B0101
Rap guanine nucleotide exchange factor 33003
Glutamate receptor ionotropic, NMDA 1 0202
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Glutamate receptor ionotropic, NMDA 3A0202
Translocator protein0101
Smad32002
5-hydroxytryptamine receptor 1A0101
Type-1 angiotensin II receptor0101
Chain A, Ferritin light chain4004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
Dihydrofolate reductase0101
Dipeptidyl peptidase 40101
Solute carrier family 22 member 10001
Multidrug and toxin extrusion protein 10101
Chain E, Fibrin beta chain0101
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
hypoxia-inducible factor 1 alpha subunit1001
Caspase 6, apoptosis-related cysteine peptidase0001
Microtubule-associated protein tau1001
TSHR protein1001
Apoptotic peptidase activating factor 10101
caspase 7, apoptosis-related cysteine protease1001
progesterone receptor2002
isocitrate dehydrogenase 1, partial1001
G3003
luciferase1001
caspase-31001
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
thyroid hormone receptor beta isoform a2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
heat shock protein beta-11001
pyruvate kinase PKM isoform a1001
DNA polymerase beta1001
flap endonuclease 11001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
DNA polymerase eta isoform 12002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Vpr1001
muscleblind-like protein 1 isoform 11001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A2002
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
HLA class I histocompatibility antigen, B alpha chain 3003
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Alpha-1B adrenergic receptor0202
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0202
Cruzipain0101
Alpha-synuclein1001
Alpha-1A adrenergic receptor0202
Guanine nucleotide-binding protein G2002
TAR DNA-binding protein 432002
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Inositol hexakisphosphate kinase 13003
Zinc finger protein mex-50011
cytochrome P450 2C9, partial3003
phosphoglycerate kinase1001
Chain A, Beta-lactamase3003
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
Serine racemase0101
Atrial natriuretic peptide receptor 10101
endonuclease IV1001
USP1 protein, partial3003
nonstructural protein 11001
Parkin1001
arylsulfatase A1001
peripheral myelin protein 22 isoform 11001
nuclear receptor ROR-gamma isoform 11001
M-phase phosphoprotein 81001
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent calcium channel gamma-3 subunit0101
Voltage-dependent T-type calcium channel subunit alpha-1H0101
Adenosine receptor A30101
Cannabinoid receptor 10202
Cytochrome P450 2C190101
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel gamma-7 subunit0101
Voltage-dependent N-type calcium channel subunit alpha-1B0202
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Transient receptor potential cation channel subfamily A member 10011
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Rap guanine nucleotide exchange factor 41001
Bile acid receptor0202
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Voltage-dependent calcium channel gamma-2 subunit0101
NFKB1 protein, partial1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
Alpha-1B adrenergic receptor 0011
ras-related protein Rab-9A1001
Beta-3 adrenergic receptor0011
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-2B adrenergic receptor0001
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
apical membrane antigen 1, AMA11001
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
Thromboxane A2 receptor 0001
Type-1 angiotensin II receptor0101
Squalene synthase0101
Platelet glycoprotein VI0011
Leukotriene B4 receptor 20011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]