Page last updated: 2024-08-05 15:42:48

calcium ionophore

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ChEBI ID: 22986

Members (2)

MemberDefinitionClass
okadaic acidA polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells.okadaic acid
sq-23377A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes.ionomycin

Research

Studies (4,312)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990522 (12.11)18.7374
1990's2,060 (47.77)18.2507
2000's1,159 (26.88)29.6817
2010's498 (11.55)24.3611
2020's73 (1.69)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials10 (0.23%)5.53%
Reviews28 (0.64%)6.00%
Case Studies9 (0.20%)4.05%
Observational3 (0.07%)0.25%
Other4,349 (98.86%)84.16%

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, Serine/threonine protein phosphatase PP1-gamma catalytic subunitHomo sapiens (human)IC500.097011
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B Gallus gallus (chicken)IC500.000944
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformHomo sapiens (human)IC500.007011
Serine/threonine-protein phosphatase PP1-gamma catalytic subunitHomo sapiens (human)IC501.96631111
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC500.453733