Roles > calcium ionophore
Page last updated: 2024-08-05 15:42:48
calcium ionophore
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ChEBI ID: 22986
Members (2)
| Member | Definition | Class |
|---|
| okadaic acid | A polycyclic ether that is produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. A polyketide, polyether derivative of a C38 fatty acid, it is one of the primary causes of diarrhetic shellfish poisoning (DSP). It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. | okadaic acid |
| sq-23377 | A very long-chain fatty acid that is docosa-10,16-dienoic acid which is substituted by methyl groups at positions 4, 6, 8, 12, 14, 18 and 20, by hydroxy groups at positions 11, 19 and 21, and by a (2',5-dimethyloctahydro-2,2'-bifuran-5-yl)ethanol group at position 21. An ionophore produced by Streptomyces conglobatus, it is used in research to raise the intracellular level of Ca(2+) and as a research tool to understand Ca(2+) transport across biological membranes. | ionomycin |
Research
Studies (4,312)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 522 (12.11) | 18.7374 |
| 1990's | 2,060 (47.77) | 18.2507 |
| 2000's | 1,159 (26.88) | 29.6817 |
| 2010's | 498 (11.55) | 24.3611 |
| 2020's | 73 (1.69) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 10 (0.23%) | 5.53% |
| Reviews | 28 (0.64%) | 6.00% |
| Case Studies | 9 (0.20%) | 4.05% |
| Observational | 3 (0.07%) | 0.25% |
| Other | 4,349 (98.86%) | 84.16% |
Protein Targets (5)
Inhibition Measurements