Page last updated: 2024-11-12
retinyl retinoate
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
retinyl retinoate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 10303376 |
| CHEMBL ID | 451039 |
| SCHEMBL ID | 990650 |
| MeSH ID | M0522845 |
Synonyms (19)
| Synonym |
|---|
| retinylretinoate |
| CHEMBL451039 |
| retinyl retinoate |
| retinoic acid, retin-15-yl ester |
| 5at5x9j439 , |
| 15498-86-9 |
| ep-reti plus |
| retinoic acid, ester with retinol |
| unii-5at5x9j439 |
| retinyl retinoate [inci] |
| SCHEMBL990650 |
| DTXSID00165764 |
| QNCTWCFXYGJGKU-CHOOPKNISA-N |
| [(2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate |
| Q27261759 |
| (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl (2e,4e,6e,8e)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate |
| CS-0447208 |
| retinoic acid retin-15-yl ester |
| retinoic acid ester with retinol |
Research Excerpts
Overview
Retinyl retinoate is an ester of all-trans retinoic acid (RA) and all- trans retinol. It has reduced toxicity due to blocking of the carboxyl end group of RA. It also has higher skin regeneration activity than retinOL.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Retinyl retinoate, which is an ester of all-trans retinoic acid (RA) and all-trans retinol, has reduced toxicity due to blocking of the carboxyl end group of RA and higher skin regeneration activity than retinol." | ( Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial. Jung, H; Jung, S; Kim, B; Kim, H; Kim, J; Kim, N; Lee, J; Mun, J; Ryoo, H, 2010) | 1.33 |
Effects
| Excerpt | Reference | Relevance |
|---|---|---|
| "Retinyl retinoate has a potent anti-wrinkle activity, and the PLA-retinyl retinoate microsphere could be a useful cosmeceutical product for anti-aging purposes." | ( Novel anti-wrinkle effect of cosmeceutical product with new retinyl retinoate microsphere using biodegradable polymer. Cho, H; Jung, H; Kim, H; Kim, M; Lee, J; Lee, K; Moon, T; Moon, W; Mun, J; Park, N; Quan, Y; Ryoo, H, 2012) | 2.06 |
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "The retinyl retinoate-treated wrinkles improved compared with wrinkles treated with placebo or retinol, as assessed by both the investigators and the subjects. " | ( Improvement in skin wrinkles from the use of photostable retinyl retinoate: a randomized controlled trial. Jung, H; Jung, S; Kim, B; Kim, H; Kim, J; Kim, N; Lee, J; Mun, J; Ryoo, H, 2010) | 1.16 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (11)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID404768 | Stability in human fibroblasts assessed as retention time after 2 days | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404775 | Induction of CRABP 2 mRNA expression in human normal fibroblast at 1 uM by Western blot relative to control | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404770 | Thermal stability at 4 degC after 4 weeks | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404773 | Decrease in collagenase expression in Coll-CAT gene transfected human HaCaT cells co-transfected with c-Jun relative to control | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404777 | Induction of collagen biosynthesis in human normal fibroblast | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404774 | Decrease in collagenase expression in Coll-CAT gene transfected human HaCaT cells co-transfected with c-Jun and retinoic acid receptor relative to control | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404778 | Increase in transcriptional activity of RARalpha receptor epressed in human HaCaT cells co-transfected with DR5-tk-CAT reporter plasmid assessed as beta-galactosidase activity by CAT-ELISA | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404772 | Cytotoxicity against human normal fibroblast after 1 day by MTT assay | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404769 | Photostability after UV irradiation | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404779 | Inhibition of AP1 expressed in human HaCaT cells transfected with Coll-CAT reporter gene assessed as collagenase expression by CAT-ELISA | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| AID404776 | Induction of CRABP 2 mRNA expression in human normal fibroblast at 10 uM by Western blot relative to control | 2008 | Bioorganic & medicinal chemistry, Jun-15, Volume: 16, Issue:12 | Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 30.12
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (30.12) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (42.86%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (57.14%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||