A reagent used to couple amino acids during artificial peptide synthesis.
ChEBI ID: 73668
| Member | Definition | Class |
|---|---|---|
| 1,3-diisopropylcarbodiimide | A carbodiimide compound having an isopropyl substituent on both nitrogen atoms. | 1,3-diisopropylcarbodiimide |
| dicyclohexylcarbodiimide | A carbodiimide compound having a cyclohexyl substituent on both nitrogen atoms. | 1,3-dicyclohexylcarbodiimide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 809 (60.96) | 18.7374 |
| 1990's | 304 (22.91) | 18.2507 |
| 2000's | 133 (10.02) | 29.6817 |
| 2010's | 71 (5.35) | 24.3611 |
| 2020's | 10 (0.75) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 31 (2.22%) | 6.00% |
| Case Studies | 9 (0.65%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,355 (97.13%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 29.6896 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 15.1173 | 7 | 10 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 24.3327 | 3 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 2.8613 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.2208 | 9 | 15 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 14.5622 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 9.3592 | 6 | 12 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.5520 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 46.3053 | 2 | 5 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 20.3246 | 1 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 35.3749 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 113.0040 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 34.4214 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 53.0804 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 3.9811 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 14.1623 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 8.4331 | 3 | 6 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 43.6465 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 18.8336 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.6253 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 17.8329 | 3 | 5 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 12.8824 | 5 | 8 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.8232 | 2 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 53.1380 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 57.9932 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 12.1972 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 34.4798 | 3 | 5 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 13.0009 | 4 | 7 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 55.4772 | 1 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 55.4772 | 1 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 10.1751 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 42.2395 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 35.3749 | 1 | 2 |