ascorbic-acid and physostigmine-salicylate

Aimed at the centralized manufacture of physostigmin salicylate injection solutions, the efficacy of different stabilizators has been studied under conditions of the thermic load. As for physostigmin sodium pyrosulphite is no antioxidant but a discolouration-protective agent. A decrease of the physostigmin content is not avoided. During the tests ascorbic acid proved to be the most efficient stabilizator, because its application resulted in the most favourable rates of storage stability and usability and at the same time in a pH stabilization to the optimum range of 3 necessary for the physostigmin keeping quality. An additionally stabilizing effect is obtained by a 5 min carbon dioxide gasing of the solutions. Moreover, ascorbic acid is as viewed in physiological perspective the most harmless one. A servicable stabilizing procedure for generation of 0.1% physostigmin salicylate injection solutions has been developed on this basis. These solutions had repeatedly and successfully been applied an antidote to intoxications with atropine syndrome, especially to intoxications with tricyclic anti-depressives and phenothiazines.

Topics: Ascorbic Acid; Carbon Dioxide; Chemistry, Pharmaceutical; Drug Stability; Excipients; Hydrogen-Ion Concentration; Injections; Physostigmine; Solutions; Temperature